Ultrasound-driven radical chain reaction and immunoregulation of piezoelectric-based hybrid coating for treating implant infection
Biomaterials. 2024 Mar 14;307:122532. doi: 10.1016/j.biomaterials.2024.122532. Online ahead of print.ABSTRACTThe poor efficiency of US-responsive coatings on implants restricts their practical application. Immunotherapy that stimulates immune cells to enhance their antibacterial activity is expected to synergize with sonodynamic therapy for treating implant infection effectively and safely. Herein, US-responsive hybrid coatings composed of the oxygen-deficient BaTiO3 nanorod arrays and l-arginine (BaTiO3-x/LA) are designed and prepared on titanium implants for sonocatalytic therapy-cooperated immunotherapy to treat Methici...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Menglin Sun Jiameng Wang Xiaobo Huang Ruiqiang Hang Peide Han Jiqiang Guo Xiaohong Yao Paul K Chu Xiangyu Zhang Source Type: research
MDSC-targeting gold nanoparticles enhance PD-1 tumor immunotherapy by inhibiting NLRP3 inflammasomes
In this study, we revealed that gold nanoparticles (Au NPs) with a size of 30 nm disrupted NLRP3 inflammasome, but not other inflammasomes, in bone marrow-derived macrophages through abrogating NLRP3-NEK7 interactions mediated by reactive oxygen species (ROS). Density functional theory (DFT) calculations provided insights into the mechanism underlying the exceptional ROS scavenging capabilities of Au NPs. Additionally, when coupled with H6, a small peptide targeting MDSCs, Au NPs demonstrated the capacity to effectively reduce IL-1β levels and diminish the MDSCs population in tumor microenvironment, leading to enhanced T ...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Yangyang Zhu Pin Chen Bochuan Hu Suqin Zhong Kai Yan Yu Wu Shanshan Li Yinyin Yang Zexin Xu Yutong Lu Ying Ouyang Hui Bao Weiguang Gu Longping Wen Yunjiao Zhang Source Type: research
Magnetic natural lipid nanoparticles for oral treatment of colorectal cancer through potentiated antitumor immunity and microbiota metabolite regulation
Biomaterials. 2024 Mar 11;307:122530. doi: 10.1016/j.biomaterials.2024.122530. Online ahead of print.ABSTRACTThe therapeutic efficacy of oral nanotherapeutics against colorectal cancer (CRC) is restricted by inadequate drug accumulation, immunosuppressive microenvironment, and intestinal microbiota imbalance. To overcome these challenges, we elaborately constructed 6-gingerol (Gin)-loaded magnetic mesoporous silicon nanoparticles and functionalized their surface with mulberry leaf-extracted lipids (MLLs) and Pluronic F127 (P127). In vitro experiments revealed that P127 functionalization and alternating magnetic fields (AMF...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Baoyi Li Menghang Zu Aodi Jiang Yingui Cao Jiaxue Wu Mohammad-Ali Shahbazi Xiaoxiao Shi Rui L Reis Subhas C Kundu Bo Xiao Source Type: research
"On/off"-switchable crosslinked PTX-nanoformulation with improved precise delivery for NSCLC brain metastases and restrained adverse reaction over nab-PTX
In this study, we address these challenges by designing a "on/off" switchable crosslinked paclitaxel (PTX) nanocarrier, BPM-PD, with novel ultra-pH-sensitive linkages (pH 6.8 to 6.5). BPM-PD demonstrates a distinct "on/off" switchable release of the anti-cancer drug paclitaxel (PTX) in response to the acidic extratumoral microenvironment. The "off" state of BPM-PD@PTX effectively prevents premature drug release in the blood circulation, blood-brain barrier (BBB)/blood-tumor barrier (BTB), and normal brain tissue, surpassing the clinical PTX-nanoformulation (nab-PTX). Meanwhile, the "on" state facilitates precise delivery t...
Source: Biomaterials - March 16, 2024 Category: Materials Science Authors: Shuaijun Li Caiting Meng Qian Hao Ruina Zhou Luyao Dai Yucheng Guo Sitong Zhao Xin Zhou Chunju Lou Ji Xu Peng Xu Jinfan Yang Yifan Ding Yanni Lv Shengli Han Shuai Li Jing Li Huafeng Kang Zhengtao Xiao Mingqian Tan Xiaobin Ma Hao Wu Source Type: research
"On/off"-switchable crosslinked PTX-nanoformulation with improved precise delivery for NSCLC brain metastases and restrained adverse reaction over nab-PTX
In this study, we address these challenges by designing a "on/off" switchable crosslinked paclitaxel (PTX) nanocarrier, BPM-PD, with novel ultra-pH-sensitive linkages (pH 6.8 to 6.5). BPM-PD demonstrates a distinct "on/off" switchable release of the anti-cancer drug paclitaxel (PTX) in response to the acidic extratumoral microenvironment. The "off" state of BPM-PD@PTX effectively prevents premature drug release in the blood circulation, blood-brain barrier (BBB)/blood-tumor barrier (BTB), and normal brain tissue, surpassing the clinical PTX-nanoformulation (nab-PTX). Meanwhile, the "on" state facilitates precise delivery t...
Source: Biomaterials - March 16, 2024 Category: Materials Science Authors: Shuaijun Li Caiting Meng Qian Hao Ruina Zhou Luyao Dai Yucheng Guo Sitong Zhao Xin Zhou Chunju Lou Ji Xu Peng Xu Jinfan Yang Yifan Ding Yanni Lv Shengli Han Shuai Li Jing Li Huafeng Kang Zhengtao Xiao Mingqian Tan Xiaobin Ma Hao Wu Source Type: research
Modeling of intravenous caspofungin administration using an intestine-on-chip reveals altered Candida albicans microcolonies and pathogenicity
Biomaterials. 2024 Mar 9;307:122525. doi: 10.1016/j.biomaterials.2024.122525. Online ahead of print.ABSTRACTCandida albicans is a commensal yeast of the human intestinal microbiota that, under predisposing conditions, can become pathogenic and cause life-threatening systemic infections (candidiasis). Fungal-host interactions during candidiasis are commonly studied using conventional 2D in vitro models, which have provided critical insights into the pathogenicity. However, microphysiological models with a higher biological complexity may be more suitable to mimic in vivo-like infection processes and antifungal drug efficacy...
Source: Biomaterials - March 15, 2024 Category: Materials Science Authors: Tim Kaden Raquel Alonso-Roman Parastoo Akbarimoghaddam Alexander S Mosig Katja Graf Martin Raasch Bianca Hoffmann Marc T Figge Bernhard Hube Mark S Gresnigt Source Type: research
Perfusable adipose decellularized extracellular matrix biological scaffold co-recellularized with adipose-derived stem cells and L6 promotes functional skeletal muscle regeneration following volumetric muscle loss
This study demonstrates that co-seeding ASCs and L6 cells through vascular pedicles is a promising recellularization strategy for adECM biological scaffolds, and the engineered muscle tissue constructed based on this has significant therapeutic effects on VML. Overall, this study provides a new paradigm for optimizing and developing dECM-based therapeutic strategies.PMID:38489911 | DOI:10.1016/j.biomaterials.2024.122529 (Source: Biomaterials)
Source: Biomaterials - March 15, 2024 Category: Materials Science Authors: Wei Liang Meng Han Guan Li Wanwen Dang Huiting Wu Xiaoyu Meng Yonghuan Zhen Weibo Lin Rigele Ao Xiaoqing Hu Yang An Source Type: research
Human chemically-derived hepatic progenitors (hCdHs) as a source of liver organoid generation: Application in regenerative medicine, disease modeling, and toxicology testing
CONCLUSION: hCdHOs provide a novel patient-specific stem cell-based platform for regenerative medicine, toxicology testing and modeling liver diseases.PMID:38465578 | DOI:10.1016/j.biomaterials.2023.122360 (Source: Biomaterials)
Source: Biomaterials - March 11, 2024 Category: Materials Science Authors: Soraya Salas-Silva Yohan Kim Tae Hun Kim Myounghoi Kim Daekwan Seo Jeonghoon Choi Valentina M Factor Haeng Ran Seo Yeonhwa Song Gyu Sung Choi Yun Kyung Jung Kungsik Kim Kyeong Geun Lee Jaemin Jeong Ji Hyun Shin Dongho Choi Source Type: research
Cleaved SPP1-rich extracellular vesicles from osteoclasts promote bone regeneration via TGF β1/SMAD3 signaling
In conclusion, our findings prove an important role of SPP1, present as cargo in OC-derived EVs, in signaling to MSCs and driving their differentiation into OBs. This biological mechanism implies a paradigm shift regarding the role of osteoclasts and their signaling toward the treatment of skeletal disorders which require bone formation.PMID:38465579 | DOI:10.1016/j.biomaterials.2023.122367 (Source: Biomaterials)
Source: Biomaterials - March 11, 2024 Category: Materials Science Authors: Abdullah Faqeer Mengzhen Wang Gulzar Alam Arshad Ahmed Padhiar Dexiu Zheng Zhiming Luo Irene Shuping Zhao Guangqian Zhou Jeroen J J P van den Beucken Huanan Wang Yang Zhang Source Type: research
Human chemically-derived hepatic progenitors (hCdHs) as a source of liver organoid generation: Application in regenerative medicine, disease modeling, and toxicology testing
CONCLUSION: hCdHOs provide a novel patient-specific stem cell-based platform for regenerative medicine, toxicology testing and modeling liver diseases.PMID:38465578 | DOI:10.1016/j.biomaterials.2023.122360 (Source: Biomaterials)
Source: Biomaterials - March 11, 2024 Category: Materials Science Authors: Soraya Salas-Silva Yohan Kim Tae Hun Kim Myounghoi Kim Daekwan Seo Jeonghoon Choi Valentina M Factor Haeng Ran Seo Yeonhwa Song Gyu Sung Choi Yun Kyung Jung Kungsik Kim Kyeong Geun Lee Jaemin Jeong Ji Hyun Shin Dongho Choi Source Type: research
Cleaved SPP1-rich extracellular vesicles from osteoclasts promote bone regeneration via TGF β1/SMAD3 signaling
In conclusion, our findings prove an important role of SPP1, present as cargo in OC-derived EVs, in signaling to MSCs and driving their differentiation into OBs. This biological mechanism implies a paradigm shift regarding the role of osteoclasts and their signaling toward the treatment of skeletal disorders which require bone formation.PMID:38465579 | DOI:10.1016/j.biomaterials.2023.122367 (Source: Biomaterials)
Source: Biomaterials - March 11, 2024 Category: Materials Science Authors: Abdullah Faqeer Mengzhen Wang Gulzar Alam Arshad Ahmed Padhiar Dexiu Zheng Zhiming Luo Irene Shuping Zhao Guangqian Zhou Jeroen J J P van den Beucken Huanan Wang Yang Zhang Source Type: research
Human chemically-derived hepatic progenitors (hCdHs) as a source of liver organoid generation: Application in regenerative medicine, disease modeling, and toxicology testing
CONCLUSION: hCdHOs provide a novel patient-specific stem cell-based platform for regenerative medicine, toxicology testing and modeling liver diseases.PMID:38465578 | DOI:10.1016/j.biomaterials.2023.122360 (Source: Biomaterials)
Source: Biomaterials - March 11, 2024 Category: Materials Science Authors: Soraya Salas-Silva Yohan Kim Tae Hun Kim Myounghoi Kim Daekwan Seo Jeonghoon Choi Valentina M Factor Haeng Ran Seo Yeonhwa Song Gyu Sung Choi Yun Kyung Jung Kungsik Kim Kyeong Geun Lee Jaemin Jeong Ji Hyun Shin Dongho Choi Source Type: research
Cleaved SPP1-rich extracellular vesicles from osteoclasts promote bone regeneration via TGF β1/SMAD3 signaling
In conclusion, our findings prove an important role of SPP1, present as cargo in OC-derived EVs, in signaling to MSCs and driving their differentiation into OBs. This biological mechanism implies a paradigm shift regarding the role of osteoclasts and their signaling toward the treatment of skeletal disorders which require bone formation.PMID:38465579 | DOI:10.1016/j.biomaterials.2023.122367 (Source: Biomaterials)
Source: Biomaterials - March 11, 2024 Category: Materials Science Authors: Abdullah Faqeer Mengzhen Wang Gulzar Alam Arshad Ahmed Padhiar Dexiu Zheng Zhiming Luo Irene Shuping Zhao Guangqian Zhou Jeroen J J P van den Beucken Huanan Wang Yang Zhang Source Type: research
Human chemically-derived hepatic progenitors (hCdHs) as a source of liver organoid generation: Application in regenerative medicine, disease modeling, and toxicology testing
CONCLUSION: hCdHOs provide a novel patient-specific stem cell-based platform for regenerative medicine, toxicology testing and modeling liver diseases.PMID:38465578 | DOI:10.1016/j.biomaterials.2023.122360 (Source: Biomaterials)
Source: Biomaterials - March 11, 2024 Category: Materials Science Authors: Soraya Salas-Silva Yohan Kim Tae Hun Kim Myounghoi Kim Daekwan Seo Jeonghoon Choi Valentina M Factor Haeng Ran Seo Yeonhwa Song Gyu Sung Choi Yun Kyung Jung Kungsik Kim Kyeong Geun Lee Jaemin Jeong Ji Hyun Shin Dongho Choi Source Type: research
Cleaved SPP1-rich extracellular vesicles from osteoclasts promote bone regeneration via TGF β1/SMAD3 signaling
In conclusion, our findings prove an important role of SPP1, present as cargo in OC-derived EVs, in signaling to MSCs and driving their differentiation into OBs. This biological mechanism implies a paradigm shift regarding the role of osteoclasts and their signaling toward the treatment of skeletal disorders which require bone formation.PMID:38465579 | DOI:10.1016/j.biomaterials.2023.122367 (Source: Biomaterials)
Source: Biomaterials - March 11, 2024 Category: Materials Science Authors: Abdullah Faqeer Mengzhen Wang Gulzar Alam Arshad Ahmed Padhiar Dexiu Zheng Zhiming Luo Irene Shuping Zhao Guangqian Zhou Jeroen J J P van den Beucken Huanan Wang Yang Zhang Source Type: research