Corrigendum to "Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells" [Biomaterials 37 (2015) 405-414].
Corrigendum to "Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells" [Biomaterials 37 (2015) 405-414]. Biomaterials. 2020 Sep 13;263:120373 Authors: Sun R, Liu Y, Li SY, Shen S, Du XJ, Xu CF, Cao ZT, Bao Y, Zhu YH, Li YP, Yang XZ, Wang J PMID: 32937258 [PubMed - as supplied by publisher] (Source: Biomaterials)
Source: Biomaterials - September 13, 2020 Category: Materials Science Authors: Sun R, Liu Y, Li SY, Shen S, Du XJ, Xu CF, Cao ZT, Bao Y, Zhu YH, Li YP, Yang XZ, Wang J Tags: Biomaterials Source Type: research

Corrigendum to "Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics" [Biomaterials 192 (2019) 551-559].
Corrigendum to "Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics" [Biomaterials 192 (2019) 551-559]. Biomaterials. 2020 Sep 12;263:120371 Authors: Siemer S, Westmeier D, Barz M, Eckrich J, Wünsch D, Seckert C, Thyssen C, Schilling O, Hasenberg M, Pang C, Docter D, Knauer SK, Stauber RH, Strieth S PMID: 32932141 [PubMed - as supplied by publisher] (Source: Biomaterials)
Source: Biomaterials - September 12, 2020 Category: Materials Science Authors: Siemer S, Westmeier D, Barz M, Eckrich J, Wünsch D, Seckert C, Thyssen C, Schilling O, Hasenberg M, Pang C, Docter D, Knauer SK, Stauber RH, Strieth S Tags: Biomaterials Source Type: research

Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand.
Lactoferrin, a multi-functional glycoprotein: Active therapeutic, drug nanocarrier & targeting ligand. Biomaterials. 2020 Sep 09;263:120355 Authors: Elzoghby AO, Abdelmoneem MA, Hassanin IA, Abd Elwakil MM, Elnaggar MA, Mokhtar S, Fang JY, Elkhodairy KA Abstract Recent progress in protein-based nanomedicine, inspired by the success of Abraxane® albumin-paclitaxel nanoparticles, have resulted in novel therapeutics used for treatment of challenging diseases like cancer and viral infections. However, absence of specific drug targeting, poor pharmacokinetics, premature drug release, and off-target...
Source: Biomaterials - September 9, 2020 Category: Materials Science Authors: Elzoghby AO, Abdelmoneem MA, Hassanin IA, Abd Elwakil MM, Elnaggar MA, Mokhtar S, Fang JY, Elkhodairy KA Tags: Biomaterials Source Type: research

Photocrosslinkable nanocomposite ink for printing strong, biodegradable and bioactive bone graft.
Abstract 3D printing is known as a cost-effective technique that shows huge potential in fabrication of graft substitutes for bone tissue regeneration. However, the tradeoff between 3D printability, mechanical strength and bioactivity of the printed materials (i.e., inks) remains a challenge. In this work, we present a novel photocrosslinkable nanocomposite ink composed of tri-block poly (lactide-co-propylene glycol-co-lactide) dimethacrylate (PmLnDMA, m and n respectively represent the unit length of propylene glycol and lactide) and hydroxyethyl methacrylate (HEMA)-functionalized hydroxyapatite nanoparticles (nH...
Source: Biomaterials - September 8, 2020 Category: Materials Science Authors: Yang Y, Zhang Q, Xu T, Zhang H, Zhang M, Lu L, Hao Y, Fuh JH, Zhao X Tags: Biomaterials Source Type: research

Highly improved aqueous lubrication of polymer surface by noncovalently bonding hyaluronic acid-based hydration layer for endotracheal intubation.
Abstract Hydration lubrication is the key responsible for the exceptionally low boundary friction between biosurfaces. However, it is a challenge to settle a hydration layer on a polymer surface via a noncovalent manner. Herein, we develop a highly lubricated coating absorbed onto the polymer surface via intermolecular association of hyaluronic acid (HA)-based micelles. A poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) triblock copolymer (Pluronic, F127) is recruited to complex with HA and further self-assembled to form a thick micelle layer. High water-retaining capacity of the HA/F127 coating...
Source: Biomaterials - September 6, 2020 Category: Materials Science Authors: Li YP, Liu W, Liu YH, Ren Y, Wang ZG, Zhao B, Huang S, Xu JZ, Li ZM Tags: Biomaterials Source Type: research

Nanocomposite hydrogel with NIR/magnet/enzyme multiple responsiveness to accurately manipulate local drugs for on-demand tumor therapy.
Abstract Chemotherapy is one of the most commonly utilized approaches to treat malignant tumor. However, the well-controlled chemotherapy able to accurately manipulate local drugs for on-demand tumor treatment is still a challenge. Herein, a magnet and light dual-responsive hydrogel combining thermosensitive poly(N-acryloyl glycinamide) (PNAGA), doxorubicin (DOX) loaded and polyester (PE) capped mesoporous silica nanocarriers (MSNs) as well as Fe3O4 nanoparticles (Fe3O4 NPs) grafted graphene oxide (GO) was fabricated to address above issue. The Fe3O4 NPs and GO respectively serve as magnetothermal agent and photot...
Source: Biomaterials - September 2, 2020 Category: Materials Science Authors: Yuan P, Yang T, Liu T, Yu X, Bai Y, Zhang Y, Chen X Tags: Biomaterials Source Type: research

Biochemical reprogramming of tumors for active modulation of receptor-mediated nanomaterial delivery.
Abstract Here we report that reactive oxygen species (ROS) can reprogram cancer cells to increase the expression of specific receptors and modulate the delivery of nanomaterials. Gold and γ-polyglutamic acid (γ-PGA) hybrid nanoparticles (PGANP) were prepared via a facile single-step process. Gold nanoclusters in PGANP were dispersed within the tangled γ-PGA matrix of the nanoparticles. The condensed assembly of gold nanoclusters in γ-PGA matrix enabled the interparticle plasmon coupling effect, which lacks in single gold nanoparticles. Compared with gold nanoparticles of the similar sizes, ...
Source: Biomaterials - September 2, 2020 Category: Materials Science Authors: Ko S, Park J, Lee Y, Lee DW, Macgregor RB, Oh YK Tags: Biomaterials Source Type: research

Tailored elasticity combined with biomimetic surface promotes nanoparticle transcytosis to overcome mucosal epithelial barrier.
This study may provide important knowledge for the design of functional nanovehicles to efficiently overcome mucosal epithelial barriers in the future. PMID: 32896816 [PubMed - as supplied by publisher] (Source: Biomaterials)
Source: Biomaterials - August 30, 2020 Category: Materials Science Authors: Zheng Y, Xing L, Chen L, Zhou R, Wu J, Zhu X, Li L, Xiang Y, Wu R, Zhang L, Huang Y Tags: Biomaterials Source Type: research

NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation.
In conclusion, NF71 efficiently delivers miRNA mimics into KCs as well as DCs, and therefore may have advantage in therapeutic delivery of miRNAs in case of inflammatory skin diseases. PMID: 32896817 [PubMed - as supplied by publisher] (Source: Biomaterials)
Source: Biomaterials - August 29, 2020 Category: Materials Science Authors: Carreras-Badosa G, Maslovskaja J, Periyasamy K, Urgard E, Padari K, Vaher H, Tserel L, Gestin M, Kisand K, Arukuusk P, Lou C, Langel Ü, Wengel J, Pooga M, Rebane A Tags: Biomaterials Source Type: research

Cancer-specific drug-drug nanoparticles of pro-apoptotic and cathepsin B-cleavable peptide-conjugated doxorubicin for drug-resistant cancer therapy.
Abstract Chemotherapy has shown remarkable therapeutic efficacy for various types of cancer. However, drug resistance reduces the effectiveness and sensitivity of chemotherapy, leading treatment failure and cancer relapse in many clinical indications. Herein, we propose cancer-specific drug-drug nanoparticles (DD-NPs) that improve the therapeutic efficacy of chemotherapy against drug-resistant cancer. Cancer-specific and pro-apoptotic drug-drug conjugate was prepared by conjugating the pro-apoptotic peptide drug (SMAC; Ala-Val-Pro-Ile-Ala-Gln, AVPIAQ) and cathepsin B-cleavable peptide (Phe-Arg-Arg-Gly, FRRG) to a ...
Source: Biomaterials - August 26, 2020 Category: Materials Science Authors: Shim MK, Moon Y, Yang S, Kim J, Cho H, Lim S, Yoon HY, Seong JK, Kim K Tags: Biomaterials Source Type: research

Bundling of mRNA strands inside polyion complexes improves mRNA delivery efficiency in vitro and in vivo.
This study proposes a combinational system of RNA nanotechnology and mRNA polyplexes, by focusing on mRNA steric structure inside the polyplexes. Firstly, several mRNA strands are bundled through hybridization with RNA oligonucleotide crosslinkers to obtain tight mRNA structure, and then the bundled mRNA is mixed with poly(ethylene glycol) (PEG)-polycation block copolymers to prepare PEG-coated polyplex micelles (PMs). mRNA bundling results in highly condensed mRNA packaging inside PM core with dense PEG chains on the surface, thereby, improving PM stability against polyion exchange reaction and ribonuclease (RNase) attack...
Source: Biomaterials - August 24, 2020 Category: Materials Science Authors: Koji K, Yoshinaga N, Mochida Y, Hong T, Miyazaki T, Kataoka K, Osada K, Cabral H, Uchida S Tags: Biomaterials Source Type: research

Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinson's disease.
Abstract The treatment of Parkinson's disease (PD) is hampered by the blood-brain barrier (BBB). As such, there is an urgent need for the development of a novel nanoplatform capable of penetrating the BBB in order to effectively treat PD. In the present study, we utilized black phosphorus nanosheets (BP) containing the brain-targeting ligand lactoferrin (Lf) and loaded with Paeoniflorin (Pae) to obtain Lf-BP-Pae. Through an effective photo-thermal effect, these Lf-BP-Pae particles were capable of traversing the BBB and effectively treating PD in a targeted manner. Importantly, this BP-based nanoplatform was capabl...
Source: Biomaterials - August 23, 2020 Category: Materials Science Authors: Xiong S, Li Z, Liu Y, Wang Q, Luo J, Chen X, Xie Z, Zhang Y, Zhang H, Chen T Tags: Biomaterials Source Type: research

Versatile hollow COF nanospheres via manipulating transferrin corona for precise glioma-targeted drug delivery.
Abstract Covalent organic framework (COF) nanoparticles for interference-free targeted drug delivery to glioma remains in its infancy. Herein, hollow COF nanospheres with high crystallinity and uniformed sizes were facilely prepared via heterogeneous nucleation-growth. The prepared COF had large surface area/pore volume and exhibited appropriate degradation behavior under acid environment, where therefore doxorubicin was effectively encapsulated and exhibited a pH-sensitive release. Most charmingly, T10 peptide that has high affinity with transferrin (Tf), was conjugated to endow the hollow COF interesting propert...
Source: Biomaterials - August 20, 2020 Category: Materials Science Authors: Huo T, Yang Y, Qian M, Jiang H, Du Y, Zhang X, Xie Y, Huang R Tags: Biomaterials Source Type: research

Methacrylic acid copolymer coating of polypropylene mesh chamber improves subcutaneous islet engraftment.
In this study, a porous cell transplantation device was coated with 40% methacrylic acid-co-isodecyl acrylate (MAA-co-IDA), a biomaterial which promotes a vascular response without additional biologics. Three weeks after device implantation, the vessel density surrounding the device was double that of an uncoated device. The vasculature was mature and connected to the host bloodstream, as demonstrated by perfusion studies and histology. The tissue response to coated devices demonstrated lower levels of inflammation, measured by reduced gene expression of i-NOS and IL1β, and increased expression of IL4. Syngeneic islet...
Source: Biomaterials - August 15, 2020 Category: Materials Science Authors: Coindre VF, Kinney SM, Sefton MV Tags: Biomaterials Source Type: research

Nanoparticle-based "Two-pronged" approach to regress atherosclerosis by simultaneous modulation of cholesterol influx and efflux.
Nanoparticle-based "Two-pronged" approach to regress atherosclerosis by simultaneous modulation of cholesterol influx and efflux. Biomaterials. 2020 Aug 15;260:120333 Authors: He H, Wang J, Yannie PJ, Korzun WJ, Yang H, Ghosh S Abstract Reduction of lipoprotein uptake by macrophages and stimulation of cholesterol efflux are two essential steps required for atherosclerotic plaque regression. We used the optimized mannose-functionalized dendrimeric nanoparticle (mDNP)-based platform for macrophage-specific delivery of therapeutics to simultaneously deliver SR-A siRNA (to reduce LDL uptake) and...
Source: Biomaterials - August 15, 2020 Category: Materials Science Authors: He H, Wang J, Yannie PJ, Korzun WJ, Yang H, Ghosh S Tags: Biomaterials Source Type: research

Mechanotransduction is a context-dependent activator of TGF- β signaling in mesenchymal stem cells.
Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells. Biomaterials. 2020 Aug 15;259:120331 Authors: Vermeulen S, Roumans N, Honig F, Carlier A, Hebels DGAJ, Eren AD, Dijke PT, Vasilevich A, de Boer J Abstract We previously found that surface topographies induce the expression of the Scxa gene, encoding Scleraxis in tenocytes. Because Scxa is a TGF-β responsive gene, we investigated the link between mechanotransduction and TGF-β signaling. We discovered that mesenchymal stem cells exposed to both micro-topographies and TGF-β2 display syne...
Source: Biomaterials - August 15, 2020 Category: Materials Science Authors: Vermeulen S, Roumans N, Honig F, Carlier A, Hebels DGAJ, Eren AD, Dijke PT, Vasilevich A, de Boer J Tags: Biomaterials Source Type: research

NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens.
Abstract Despite the wide application of the traditional NIR-I phototheranostic platforms in basic research and clinical studies, problems such as tissue scattering, auto-fluorescence combined with aggregation caused quenching hamper precise image-guided phototherapy. Herein, we developed a multifunctional NIR-II phototheranostic platform using a novel AIE-based dye (ZSY-TPE) for single laser-activated imaging-guided combined photothermal and photodynamic therapies of tumors and pathogens. As confirmed through in vivo studies, the ZSY-TPE dots displayed precise and efficient high-performance NIR-II imaging-guided ...
Source: Biomaterials - August 15, 2020 Category: Materials Science Authors: Xu Y, Zhang Y, Li J, An J, Li C, Bai S, Sharma A, Deng G, Kim JS, Sun Y Tags: Biomaterials Source Type: research

Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment.
Abstract Malignant melanoma is one of the most aggressive skin cancers, posing severe threat to human health. Tyrosinase, overexpressed in melanoma cells, is a specific in-situ weapon to augment the therapeutic efficacy of melanoma-specific treatment by in-situ accelerating the activation of anti-melanoma prodrugs. Herein, we developed a tyrosinase-triggered oxidative stress amplifier, denoted as APAP@PEG/HMnO2, to achieve synergistic chemotherapy and amplified oxidative stress for melanoma-specific treatment. The APAP@PEG/HMnO2 nanosystem was constructed by encapsulating non-toxic prodrug acetaminophen (APAP) int...
Source: Biomaterials - August 15, 2020 Category: Materials Science Authors: Pu Y, Zhou B, Xiang H, Wu W, Yin H, Yue W, Yin Y, Li H, Chen Y, Xu H Tags: Biomaterials Source Type: research

Intercellular delivery of bioorthogonal chemical receptors for enhanced tumor targeting and penetration.
In this study, we developed an alternative active targeting strategy for enhanced tumor targeting and penetration through synthetic nanoparticle-mediated metabolic tumor ligand labeling for intercellular delivery of bioorthogonal chemical receptors combined with in vivo bioorthogonal click chemistry. Briefly, artificial azide-containing ligands were first labeled on perivascular tumor cells by nanoscale metabolic precursors (Az-NPs) via the enhanced permeability and retention (EPR) effect and metabolic engineering of the tumor cells. Through transport by extracellular vesicles (EVs) secreted by perivascular tumor cells, th...
Source: Biomaterials - August 14, 2020 Category: Materials Science Authors: Tu Y, Dong Y, Wang K, Shen S, Yuan Y, Wang J Tags: Biomaterials Source Type: research

Fibrinolytic tissue plasminogen activator installed redox-active nanoparticles (t-PA@iRNP) for cancer therapy.
Abstract Favorable blood flow within solid tumors has become the principal strategy for drug delivery. The use of thrombolytic drugs, such as tissue plasminogen activator (t-PA), in combination with other drugs or drug carriers may increase their therapeutic effect by increasing drug delivery near the solid tumor through fibrin degradation and blood flow restoration. We, therefore, designed t-PA-installed redox-active nanoparticles (t-PA@iRNP) to improve the perfusion of antioxidant nanoparticles in tumors, via fibrin degradation to decompress tumor vessels. Additionally, antioxidant iRNP was developed for tumor i...
Source: Biomaterials - August 14, 2020 Category: Materials Science Authors: Mei T, Shashni B, Maeda H, Nagasaki Y Tags: Biomaterials Source Type: research

Selective elimination of human pluripotent stem cells by Anti-Dsg2 antibody-doxorubicin conjugates.
Abstract The self-renewal properties of human pluripotent stem cells (hPSCs) contribute to their efficacy in tissue regeneration applications yet increase the likelihood of teratoma formation, thereby limiting their clinical utility. To address this issue, we developed a tool to specifically target and neutralize undifferentiated hPSCs, thereby minimizing tumorigenicity risk without negatively affecting regenerated and somatic tissues. Specifically, we conjugated a monoclonal antibody (K6-1) previously generated in our laboratory against desmoglein 2 (Dsg2), which is highly differentially expressed in undifferenti...
Source: Biomaterials - August 13, 2020 Category: Materials Science Authors: Park J, Lee NG, Oh M, Song J, Kim W, Kwon MG, Kim SG, Han BS, Bae KH, Lee DG, Lee SH, Park JG, Kim JH, Lee J, Min JK Tags: Biomaterials Source Type: research

Construction and performance evaluation of Hep/silk-PLCL composite nanofiber small-caliber artificial blood vessel graft.
In this study, a biodegradable graft made of composite nanofibers is introduced. A composite nanofiber core-shell structure was prepared by a combination of conjugate electrospinning and freeze-dry technology. The core fiber was poly(l-lactide-co-caprolactone) (PLCL)-based and the core fibers were coated with heparin/silk gel, which acted as a shell layer. This special structure in which the core layer was made of synthetic materials and the shell layer was made of natural materials took advantage of these two different materials. The core PLCL nanofibers provided mechanical support during vascular reconstruction, and the ...
Source: Biomaterials - August 13, 2020 Category: Materials Science Authors: Kuang H, Wang Y, Shi Y, Yao W, He X, Liu X, Mo X, Lu S, Zhang P Tags: Biomaterials Source Type: research

CCL21-loaded 3D hydrogels for T cell expansion and differentiation.
In this study, three-dimensional (3D) poly(ethylene) glycol (PEG) hydrogels covalently combined with low molecular weight heparin are engineered to resemble the lymph nodes, where T cells reproduce. In these hydrogels, PEG provides the needed structural and mechanical properties, whereas heparin is used as an anchor for the cytokine CCL21, which is present in the lymph nodes, and can affect cell migration and proliferation. The 3D structure of the hydrogel in combination with its loading capacity result in an increased primary human CD4+ T cell proliferation compared to the state-of-the-art expansion systems consisting of ...
Source: Biomaterials - August 13, 2020 Category: Materials Science Authors: Pérez Del Río E, Santos F, Rodriguez Rodriguez X, Martínez-Miguel M, Roca-Pinilla R, Arís A, Garcia-Fruitós E, Veciana J, Spatz JP, Ratera I, Guasch J Tags: Biomaterials Source Type: research

Development of a two-part biomaterial adhesive strategy for annulus fibrosus repair and ex vivo evaluation of implant herniation risk.
Abstract Intervertebral disc (IVD) herniation causes pain and disability, but current discectomy procedures alleviate pain without repairing annulus fibrosus (AF) defects. Tissue engineering strategies seal AF defects by utilizing hydrogel systems to prevent recurrent herniation, however current biomaterials are limited by poor adhesion to wetted tissue surfaces or low failure strength resulting in considerable risk of implant herniation upon spinal loading. Here, we developed a two-part repair strategy comprising a dual-modified (oxidized and methacrylated) glycosaminoglycan that can chemically adsorb an injectab...
Source: Biomaterials - August 12, 2020 Category: Materials Science Authors: DiStefano TJ, Shmukler JO, Danias G, Di Pauli von Treuheim T, Hom WW, Goldberg DA, Laudier DM, Nasser PR, Hecht AC, Nicoll SB, Iatridis JC Tags: Biomaterials Source Type: research

Mechanically induced formation and maturation of 3D-matrix adhesions (3DMAs) in human mesenchymal stem cells.
Abstract Mechanical signal is important for regulating stem cell fate, but the molecular mechanisms involved are unclear. Cell-matrix adhesions are important molecular mechanosensors that their formation and maturation are force-dependent processes. However, most studies focused on the role of cell contractility or substrate stiffness in these processes. How external mechanical force stimulates the formation and maturation of cell-matrix adhesions is largely unknown. Here, by using human mesenchymal stem cells (hMSCs)-collagen microtissues as a 3D model, we found that upon short-term dynamic compression, integrin ...
Source: Biomaterials - August 12, 2020 Category: Materials Science Authors: Li CW, Lau YT, Lam KL, Chan BP Tags: Biomaterials Source Type: research

Decellularization optimizes the inhibitory microenvironment of the optic nerve to support neurite growth.
Abstract Allogeneic or homologous tissue transplantation is an effective strategy to repair tissue injury. However, the central nervous tissues like the brain, spinal cord, and optic nerve are not ideal materials for nervous tissue regeneration due to the excessive axonal inhibitor cues in their microenvironments. In the present study, we found that decellularization optimizes the function of the adult optic nerve in supporting the oriented outgrowth of dorsal root ganglion (DRG) neurites. The neurites growing on the decellularized optic nerve (DON) showed longer extension distances than those growing on the norma...
Source: Biomaterials - August 10, 2020 Category: Materials Science Authors: Sun JH, Li G, Wu TT, Lin ZJ, Zou JL, Huang LJ, Xu HY, Wang JH, Ma YH, Zeng YS Tags: Biomaterials Source Type: research

A sequential 3D bioprinting and orthogonal bioconjugation approach for precision tissue engineering.
Abstract Recent advances in 3D bioprinting have transformed the tissue engineering landscape by enabling the controlled placement of cells, biomaterials, and bioactive agents for the biofabrication of living tissues and organs. However, the application of 3D bioprinting is limited by the availability of cytocompatible and printable biomaterials that recapitulate properties of native tissues. Here, we developed an integrated 3D projection bioprinting and orthogonal photoconjugation platform for precision tissue engineering of tailored microenvironments. By using a photoreactive thiol-ene gelatin bioink, soft hydrog...
Source: Biomaterials - August 9, 2020 Category: Materials Science Authors: Yu C, Miller KL, Schimelman J, Wang P, Zhu W, Ma X, Tang M, You S, Lakshmipathy D, He F, Chen S Tags: Biomaterials Source Type: research

Highly dispersed nano-enzyme triggered intracellular catalytic reaction toward cancer specific therapy.
Abstract Currently, reactive oxygen species (ROS)-induced apoptosis systems have drawn increasing attention in cancer therapy, owing to their specific tumor inhibition ability and great biocompatibility. Herein, we developed a highly dispersed nano-enzyme based on the assembly of natural glucose oxidase (GOD) onto CoFe-layered double hydroxides (CoFe-LDHs) monolayer nanosheets. By virtue of the high dispersion of Fe3+ within the host layer, the CoFe-LDHs nanosheets exhibit a collaborative enhanced Fenton catalytic activity with a rate constant of 3.26 × 10-4 s-1, which is 1-3 orders of magnitu...
Source: Biomaterials - August 8, 2020 Category: Materials Science Authors: Mei X, Hu T, Wang H, Liang R, Bu W, Wei M Tags: Biomaterials Source Type: research

Virus-like nanoparticle as a co-delivery system to enhance efficacy of CRISPR/Cas9-based cancer immunotherapy.
Abstract The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein 9 (Cas9) system holds great promise for the cancer gene therapy. However, due to complicated signal networks and various compensatory mechanisms in tumors, adjusting a single molecular pathway has limited effects on cancer treatments. Herein, a virus-like nanoparticle (VLN) was reported as a versatile nanoplatform to co-deliver CRISPR/Cas9 system and small molecule drugs for effective malignant cancer treatment. VLN has a core-shell structure, in which small molecule drugs and CRISPR/Cas9 system are loaded in the mes...
Source: Biomaterials - August 7, 2020 Category: Materials Science Authors: Liu Q, Wang C, Zheng Y, Zhao Y, Wang Y, Hao J, Zhao X, Yi K, Shi L, Kang C, Liu Y Tags: Biomaterials Source Type: research

Single and multi-functional coating strategies for enhancing the biocompatibility and tissue integration of blood-contacting medical implants.
Abstract Device-associated clot formation and poor tissue integration are ongoing problems with permanent and temporary implantable medical devices. These complications lead to increased rates of mortality and morbidity and impose a burden on healthcare systems. In this review, we outline the current approaches for developing single and multi-functional surface coating techniques that aim to circumvent the limitations associated with existing blood-contacting medical devices. We focus on surface coatings that possess dual hemocompatibility and biofunctionality features and discuss their advantages and shortcomings...
Source: Biomaterials - August 7, 2020 Category: Materials Science Authors: Badv M, Bayat F, Weitz JI, Didar TF Tags: Biomaterials Source Type: research

Overcoming the delivery problem for therapeutic genome editing: Current status and perspective of non-viral methods.
Abstract Besides its broad application in research and biotechnology, genome editing (GE) has great potential for clinical gene therapy, but delivery of GE tools remains a bottleneck. Whereas significant progress has been made in ex vivo GE delivery (e.g., by electroporation), establishment of efficient and safe in vivo delivery systems is still a challenge. Above and beyond standard vector requirements (safety, minimal/absent toxicity and immunogenicity, sufficient packaging capacity, targeting, straight and low-cost large-scale good manufacturing practice (GMP) production), GE delivery systems ideally use a hit-...
Source: Biomaterials - August 6, 2020 Category: Materials Science Authors: Mashel TV, Tarakanchikova YV, Muslimov AR, Zyuzin MV, Timin AS, Lepik KV, Fehse B Tags: Biomaterials Source Type: research

A novel biodegradable external stent regulates vein graft remodeling via the Hippo-YAP and mTOR signaling pathways.
Abstract Coronary artery bypass graft (CABG) has been confirmed to effectively improve the prognosis of coronary artery disease, which is a major public health concern worldwide. As the most frequently used conduits in CABG, saphenous vein grafts have the disadvantage of being susceptible to restenosis due to intimal hyperplasia. To meet the urgent clinical demand, adopting external stents (eStents) and illuminating the potential mechanisms underlying their function are important for preventing vein graft failure. Here, using 4-axis printing technology, we fabricated a novel biodegradable and flexible braided eSte...
Source: Biomaterials - August 6, 2020 Category: Materials Science Authors: Yang Q, Lei D, Huang S, Yang Y, Jiang C, Shi H, Chen W, Zhao Q, You Z, Ye X Tags: Biomaterials Source Type: research

A multilayered epithelial mucosa model of head neck squamous cell carcinoma for analysis of tumor-microenvironment interactions and drug development.
e C Abstract Pharmacotherapy of head and neck squamous cell carcinoma (HNSCC) often fails due to the development of chemoresistance and severe systemic side effects of current regimens limiting dose escalation. Preclinical models comprising all major elements of treatment resistance are urgently needed for the development of new strategies to overcome these limitations. For model establishment, we used tumor cells from patient-derived HNSCC xenografts or cell lines (SCC-25, UM-SCC-22B) and characterized the model phenotype. Docetaxel and cetuximab were selected for comparative analysis of drug-related effects at t...
Source: Biomaterials - August 6, 2020 Category: Materials Science Authors: Gronbach L, Wolff C, Klinghammer K, Stellmacher J, Jurmeister P, Alexiev U, Schäfer-Korting M, Tinhofer I, Keilholz U, Zoschke C Tags: Biomaterials Source Type: research

TGase-mediated cell membrane modification and targeted cell delivery to inflammatory endothelium.
Abstract Targeted cell delivery to lesion sites via minimally invasive approach remains an unmet need in regenerative medicine to endow controlled cell distribution and minimized side-effects. Current cell modification approaches to improve cell delivery tend to have adverse effects on cellular phenotype and functionality. Here, we rationally developed a facile and mild cell modification and targeted delivery strategy leveraging endogenous tissue transglutaminase (TGase) expressed on the surface of MSCs (Mesenchymal Stem Cells) and inflammatory endothelial cells (ECs). Cell modification by functional peptides was ...
Source: Biomaterials - August 6, 2020 Category: Materials Science Authors: Qi C, Jin Y, Chen Y, Li W, Li Y, Liang K, Li Y, Zhang Y, Du Y Tags: Biomaterials Source Type: research

NIR fluorescence for monitoring in vivo scaffold degradation along with stem cell tracking in bone tissue engineering.
Abstract Stem cell-based tissue engineering has the potential to use as an alternative for autologous tissue grafts; however, the contribution of the scaffold degradation along with the transplanted stem cells to in vivo tissue regeneration remains poorly understood. Near-infrared (NIR) fluorescence imaging has great potential to monitor implants while avoiding autofluorescence from the adjacent host tissue. To utilize NIR imaging for in vivo monitoring of scaffold degradation and cell tracking, we synthesized 800-nm emitting NIR-conjugated PCL-ran-PLLA-ran-PGA (ZW-PCLG) copolymers with three different degradation...
Source: Biomaterials - August 6, 2020 Category: Materials Science Authors: Kim SH, Park JH, Kwon JS, Cho JG, Park KG, Park CH, Yoo JJ, Atala A, Choi HS, Kim MS, Lee SJ Tags: Biomaterials Source Type: research

Palmitic acid-modified bovine serum albumin nanoparticles target scavenger receptor-A on activated macrophages to treat rheumatoid arthritis.
Abstract Palmitic acid-modified bovine serum albumin (PAB) was synthetized and found to own remarkable scavenger receptor-A (SR-A) targeting ability in vitro and in vivo, through which activated macrophages took up PAB nanoparticles (PAB NPs) 9.10 times more than bovine serum albumin nanoparticles (BSA NPs) and PAB NPs could delivery anti-inflammatory drugs celastrol (CLT) to inflamed tissues more effectively than BSA NPs. Compared with chondroitin sulfate modified BSA NPs targeting activated macrophages via CD44, PAB NPs show a more prominent targeting effect whether in vivo or in vitro. And PAB also demonstrated...
Source: Biomaterials - August 4, 2020 Category: Materials Science Authors: Gong T, Tan T, Zhang P, Li H, Deng C, Huang Y, Gong T, Zhang Z Tags: Biomaterials Source Type: research

Biomimetic CoO@AuPt nanozyme responsive to multiple tumor microenvironmental clues for augmenting chemodynamic therapy.
Abstract Chemodynamic therapy (CDT), an emerging therapeutic strategy, has been recently exploited for in situ treatment through Fenton or Fenton-like reactions to generate cytotoxic reactive oxygen species (ROS). However, current systems rely significantly on the high local oxygen levels and strongly acidic conditions (pH = 3.0-5.0). Simultaneously, the produced ROS can be rapidly consumed by intracellular glutathione (GSH) in the electron transport chain. Herein, an original and biomimetic CoO@AuPt nanocatalyst was prepared based on the assembly of Au and Pt nanoparticles (NPs) on the surface of hollow...
Source: Biomaterials - August 3, 2020 Category: Materials Science Authors: Fu S, Yang R, Zhang L, Liu W, Du G, Cao Y, Xu Z, Cui H, Kang Y, Xue P Tags: Biomaterials Source Type: research

The conductive function of biopolymer corrects myocardial scar conduction blockage and resynchronizes contraction to prevent heart failure.
Abstract Myocardial fibrosis, resulting from ischemic injury, increases tissue resistivity in the infarct area, which impedes heart synchronous electrical propagation. The uneven conduction between myocardium and fibrotic tissue leads to dys-synchronous contraction, which progresses towards ventricular dysfunction. We synthesized a conductive poly-pyrrole-chitosan hydrogel (PPY-CHI), and investigated its capabilities in improving electrical propagation in fibrotic tissue, as well as resynchronizing cardiac contraction to preserve cardiac function. In an in vitro fibrotic scar model, conductivity increased in propo...
Source: Biomaterials - August 3, 2020 Category: Materials Science Authors: He S, Wu J, Li SH, Wang L, Sun Y, Xie J, Ramnath D, Weisel RD, Yau TM, Sung HW, Li RK Tags: Biomaterials Source Type: research

Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem.
Abstract Tumor hypoxia-responsive size-switchable nanosystems for precise delivery of drug into deep tumor show great prospects for killing cancer cells with high specificity and minimal invasiveness. However, the development of versatile nanosystems is still a challenge. Herein, for the first time, we report a novel hypoxia-responsive copper metal-organic framework nanoparticles (Cu-MOF NPs) for chemodynamic therapy and sonodynamic therapy (CDT/SDT). The large size Cu-MOF NPs show good stability under normal oxygen partial pressure and enhance tumor accumulation, and it quickly degraded and released Cu2+ and Ce6 ...
Source: Biomaterials - August 3, 2020 Category: Materials Science Authors: Zhang K, Meng X, Yang Z, Dong H, Zhang X Tags: Biomaterials Source Type: research

Multifunctional biomimetic hydrogel systems to boost the immunomodulatory potential of mesenchymal stromal cells.
Abstract Mesenchymal stromal cells (MSCs) hold great therapeutic potential, in part because of their immunomodulatory properties. However, these properties can be transient and depend on multiple factors. Here, we developed a multifunctional hydrogel system to synergistically enhance the immunomodulatory properties of MSCs, using a combination of sustained inflammatory licensing and three-dimensional (3D) encapsulation in hydrogels with tunable mechanical properties. The immunomodulatory extracellular matrix hydrogels (iECM) consist of an interpenetrating network of click functionalized-alginate and fibrillar coll...
Source: Biomaterials - July 30, 2020 Category: Materials Science Authors: Gonzalez-Pujana A, Vining KH, Zhang DKY, Santos-Vizcaino E, Igartua M, Hernandez RM, Mooney DJ Tags: Biomaterials Source Type: research

Neovascularized implantable cell homing encapsulation platform with tunable local immunosuppressant delivery for allogeneic cell transplantation.
Abstract Cell encapsulation is an attractive transplantation strategy to treat endocrine disorders. Transplanted cells offer a dynamic and stimulus-responsive system that secretes therapeutics based on patient need. Despite significant advancements, a challenge in allogeneic cell encapsulation is maintaining sufficient oxygen and nutrient exchange, while providing protection from the host immune system. To this end, we developed a subcutaneously implantable dual-reservoir encapsulation system integrating in situ prevascularization and local immunosuppressant delivery, termed NICHE. NICHE structure is 3D-printed in...
Source: Biomaterials - July 25, 2020 Category: Materials Science Authors: Paez-Mayorga J, Capuani S, Hernandez N, Farina M, Chua CYX, Blanchard R, Sizovs A, Liu HC, Fraga DW, Niles JA, Salazar HF, Corradetti B, Sikora AG, Kloc M, Li XC, Gaber AO, Nichols JE, Grattoni A Tags: Biomaterials Source Type: research

Nanosized zeolites as a gas delivery platform in a glioblastoma model.
Abstract Approaches able to counteract, at least temporarily, hypoxia, a well-known factor of resistance to treatment in solid tumors are highly desirable. Herein, we report the use of nanosized zeolite crystals as hyperoxic/hypercapnic gas carriers for glioblastoma. First, the non-toxic profile of nanosized zeolite crystals in living animals (mice, rats and non-human primates) and in various cell types is presented. Second, the ability of the nanosized zeolites to act as a vasoactive agent for a targeted re-oxygenation of the tumor after intravenous injection is shown. As attested by an MRI protocol, the zeolites...
Source: Biomaterials - July 25, 2020 Category: Materials Science Authors: Anfray C, Komaty S, Corroyer-Dulmont A, Zaarour M, Helaine C, Ozcelik H, Allioux C, Toutain J, Goldyn K, Petit E, Bordji K, Bernaudin M, Valtchev V, Touzani O, Mintova S, Valable S Tags: Biomaterials Source Type: research

Self-assembly of stem cell membrane-camouflaged nanocomplex for microRNA-mediated repair of myocardial infarction injury.
Abstract Mesenchymal stem cells-derived exosomes have shown promising therapeutic effect on myocardial infarction (MI). The major hurdles remain for the use of exosomes primarily due to the low yields from cell cultures coupled with complicated purification processes. Herein we report the self-assembly of stem cell membrane-camouflaged exosome-mimicking nanocomplex that recapitulates exosome functions, achieving efficient microRNA (miRNA) delivery and miRNA-mediated myocardial repair. The nanocomplex is constructed via the self-assembly of mesenchymal stem cell membrane on miRNA loaded mesoporous silica nanopartic...
Source: Biomaterials - July 25, 2020 Category: Materials Science Authors: Yao C, Wu W, Tang H, Jia X, Tang J, Ruan X, Li F, Leong DT, Luo D, Yang D Tags: Biomaterials Source Type: research

A photosensitizer-inhibitor conjugate for photodynamic therapy with simultaneous inhibition of treatment escape pathways.
Abstract Photodynamic therapy (PDT) has been successfully demonstrated for anticancer treatment in vivo. However, tumor metastasis during PDT are still inevitable due to the activation of the epidermal growth factor receptor (EGFR). The current work describes the synthesis of a photosensitizer (PS)-EGFR inhibitor conjugate for PDT with simultaneous tumor metastasis inhibition. The conjugate efficiently internalized into cancer cells and generated reactive oxygen species (ROS) under light, indicating strong cytotoxicity even in hypoxic tumor environment. The presence of an EGFR inhibitor significantly inhibited cel...
Source: Biomaterials - July 23, 2020 Category: Materials Science Authors: Xiao M, Fan J, Li M, Xu F, Zhao X, Xi D, Ma H, Li Y, Du J, Sun W, Peng X Tags: Biomaterials Source Type: research

Genetic engineering of novel super long-acting Exendin-4 chimeric protein for effective treatment of metabolic and cognitive complications of obesity.
Abstract A common bottleneck challenge for many therapeutic proteins lies in their short plasma half-lives, which often makes the treatment far less compliant or even disables achieving sufficient therapeutic efficacy. To address this problem, we introduce a novel drug delivery strategy based on the genetic fusion of an albumin binding domain (ABD) and an anti-neonatal Fc receptor (FcRn) affibody (AFF) to therapeutic proteins. This ABD-AFF fusion strategy can provide a synergistic effect on extending the plasma residence time by, on one hand, preventing the rapid glomerular filtration via ABD-mediated albumin bind...
Source: Biomaterials - July 21, 2020 Category: Materials Science Authors: Lee JY, Park T, Hong E, Amatya R, Park KA, Park YH, Min KA, Jin M, Lee S, Hwang S, Roh GS, Shin MC Tags: Biomaterials Source Type: research

Hyaluronan promotes the regeneration of vascular smooth muscle with potent contractile function in rapidly biodegradable vascular grafts.
In this study, a biomimetic vascular graft was prepared by co-electrospinning of synthetic degradable polymers and native ECM components including collagen type-I as well as low and high molecular weight HA (LMW HA and HMW HA). Upon implantation in the rat abdominal aorta, the grafts exhibited sustained HA release that effectively enhanced the regeneration of vascular smooth muscle. Besides, LMW HA loaded vascular grafts demonstrated rapid endothelialization compared to the other groups. More importantly, HA-loaded poly(L-lactide-co-caprolactone) grafts demonstrated an optimal vascular media layer accompanied by well-organ...
Source: Biomaterials - July 16, 2020 Category: Materials Science Authors: Qin K, Wang F, Simpson RML, Zheng X, Wang H, Hu Y, Gao Z, Xu Q, Zhao Q Tags: Biomaterials Source Type: research

Biocompatible Fe-Hematoporphyrin coordination nanoplatforms with efficient sonodynamic-chemo effects on deep-seated tumors.
Abstract Sonodynamic therapy (SDT) utilizing semiconductors or organic sonosensitizers has attracted increasing attention as a noninvasive treatment for deep-seated tumors, but its practical applications are still limited due to unsatisfactory therapeutical effects. To address the issue, we reported a metal-organic nanosonosensitizer by assembling clinical drug hematoporphyrin monomethyl ether (HMME) with Fe(III) ions through covalently coordination. The Fe-HMME coordination particles (FeCPs) had the average size of ~70 nm, and they were surface-modified with phospholipids to confer high hydrophilicity and st...
Source: Biomaterials - July 16, 2020 Category: Materials Science Authors: Xu H, Yu N, Zhang J, Wang Z, Geng P, Wen M, Li M, Zhang H, Chen Z Tags: Biomaterials Source Type: research

An exosome-like programmable-bioactivating paclitaxel prodrug nanoplatform for enhanced breast cancer metastasis inhibition.
This study proposes an integrated approach for mechanism-based inhibition of tumor metastasis and manifests a promising potential of programmable-bioactivating prodrug nanoplatform for cancer metastasis inhibition. PMID: 32736255 [PubMed - as supplied by publisher] (Source: Biomaterials)
Source: Biomaterials - July 15, 2020 Category: Materials Science Authors: Wang K, Ye H, Zhang X, Wang X, Yang B, Luo C, Zhao Z, Zhao J, Lu Q, Zhang H, Kan Q, Wang Y, He Z, Sun J Tags: Biomaterials Source Type: research

A nephrotoxicity-free, iron-based contrast agent for magnetic resonance imaging of tumors.
Abstract Gadolinium-based contrast agents (GBCAs) are the most widely used T1 contrast agents for magnetic resonance imaging (MRI) and have achieved remarkable success in clinical cancer diagnosis. However, GBCAs could cause severe nephrogenic systemic fibrosis to patients with renal insufficiency. Nevertheless, GBCAs are quickly excreted from the kidneys, which shortens their imaging window and prevents long-term monitoring of the disease per injection. Herein, a nephrotoxicity-free T1 MRI contrast agent is developed by coordinating ferric iron into a telodendritic, micellar nanostructure. This new nano-enabled, ...
Source: Biomaterials - July 15, 2020 Category: Materials Science Authors: Xue X, Bo R, Qu H, Jia B, Xiao W, Yuan Y, Vapniarsky N, Lindstrom A, Wu H, Zhang D, Li L, Ricci M, Ma Z, Zhu Z, Lin TY, Louie AY, Li Y Tags: Biomaterials Source Type: research

Pre- and post-irradiation mild hyperthermia enabled by NIR-II for sensitizing radiotherapy.
Abstract The clinical application of cancer radiotherapy is critically impeded by hypoxia-induced radioresistance, insufficient DNA damage, and multiple DNA repair mechanisms. Herein we demonstrate a dual-hyperthermia strategy to potentiate radiotherapy by relieving tumor hypoxia and preventing irradiation-induced DNA damage repair. The tumor hyperthermia temperature was well-controlled by a near infrared laser with minimal side effects using PEGylated nanobipyramids (PNBys) as the photo-transducer. PNBys have narrow longitudinal localized surface plasmon resonance peak in NIR-II window with a high extinction coef...
Source: Biomaterials - July 14, 2020 Category: Materials Science Authors: Li Q, Hang L, Jiang W, Dou J, Xiao L, Tang X, Yao Y, Wang Y Tags: Biomaterials Source Type: research