A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis
In conclusion, our study delivers a generic methodology for developing and assessing AOP networks. The quantitative WoE scoring method facilitates in determining the level of support for KERs within the optimized AOP network, offering valuable insights into its utility in both scientific research and regulatory contexts. KERs supported by robust evidence represent promising candidates for inclusion in an in vitro test battery for reliably predicting chemical-induced liver steatosis within regulatory frameworks.PMID:38677583 | DOI:10.1016/j.tox.2024.153814 (Source: Toxicology)
Source: Toxicology - April 27, 2024 Category: Toxicology Authors: Anouk Verhoeven Jonas van Ertvelde Joost Boeckmans Alexandra Gatzios Ramiro Jover Birgitte Lindeman Graciela Lopez-Soop Robim M Rodrigues Anna Rapisarda Julen Sanz-Serrano Marth Stinckens Sara Sepehri Marc Teunis Mathieu Vinken Jian Jiang Tamara Vanhaecke Source Type: research
A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis
In conclusion, our study delivers a generic methodology for developing and assessing AOP networks. The quantitative WoE scoring method facilitates in determining the level of support for KERs within the optimized AOP network, offering valuable insights into its utility in both scientific research and regulatory contexts. KERs supported by robust evidence represent promising candidates for inclusion in an in vitro test battery for reliably predicting chemical-induced liver steatosis within regulatory frameworks.PMID:38677583 | DOI:10.1016/j.tox.2024.153814 (Source: Toxicology)
Source: Toxicology - April 27, 2024 Category: Toxicology Authors: Anouk Verhoeven Jonas van Ertvelde Joost Boeckmans Alexandra Gatzios Ramiro Jover Birgitte Lindeman Graciela Lopez-Soop Robim M Rodrigues Anna Rapisarda Julen Sanz-Serrano Marth Stinckens Sara Sepehri Marc Teunis Mathieu Vinken Jian Jiang Tamara Vanhaecke Source Type: research
Cannabidiol disrupts tryptophan metabolism in the human term placenta
Toxicology. 2024 Apr 23:153813. doi: 10.1016/j.tox.2024.153813. Online ahead of print.ABSTRACTThe increasing use of cannabis during pregnancy raises concerns about its impact on fetal development. While cannabidiol (CBD) shows therapeutic promise, its effects during pregnancy remain uncertain. We investigated CBD's influence on tryptophan (TRP) metabolism in the human placenta. TRP is an essential amino acid that is metabolized via the serotonin and kynurenine (KYN) pathways, which are critical for fetal neurodevelopment. We used human term villous placental explants, an advanced ex vivo model, to study CBD's impact on key...
Source: Toxicology - April 25, 2024 Category: Toxicology Authors: Ramon Portillo Cilia Abad Tetiana Synova Petr Kastner Heblik Daniel Radim Kucera Rona Karahoda Frantisek Staud Source Type: research
Cannabidiol disrupts tryptophan metabolism in the human term placenta
Toxicology. 2024 Apr 23:153813. doi: 10.1016/j.tox.2024.153813. Online ahead of print.ABSTRACTThe increasing use of cannabis during pregnancy raises concerns about its impact on fetal development. While cannabidiol (CBD) shows therapeutic promise, its effects during pregnancy remain uncertain. We investigated CBD's influence on tryptophan (TRP) metabolism in the human placenta. TRP is an essential amino acid that is metabolized via the serotonin and kynurenine (KYN) pathways, which are critical for fetal neurodevelopment. We used human term villous placental explants, an advanced ex vivo model, to study CBD's impact on key...
Source: Toxicology - April 25, 2024 Category: Toxicology Authors: Ramon Portillo Cilia Abad Tetiana Synova Petr Kastner Heblik Daniel Radim Kucera Rona Karahoda Frantisek Staud Source Type: research
Systematic literature review of heavy metal contamination of the Nigerian environment from E-waste management: associated health and carcinogenic risk assessment
This study harmonizes primary data on HMs from e-waste in different Nigerian environmental media including the air, soil, surface dust, water and plant. We estimated the possible health implications, single and aggregative soil and water pollution indices in adult and children, carcinogenic and non-carcinogenic risks secondary to HM exposure and mapped out the possible mechanism of carcinogenesis. Analysis showed that soil, water, surface dust and plant matrices in Nigerian environment are variedly but considerably contaminated with combination of HMs. The significantly high values of the hazard quotient and hazard index o...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: W M Owonikoko C G Alimba Source Type: research
Elevated intracellular Ca < sup > 2+ < /sup > functions downstream of mitodysfunction to induce Wallerian-like degeneration and necroptosis in organophosphorus-induced delayed neuropathy
This study was designed to investigate that deregulated cytosolic Ca2+ may function downstream of mitodysfunction in activating Wallerian-like degeneration and necroptosis in OPIDN. Adult hens were administrated a single dosage of 750 mg/kg tri-ortho-cresyl phosphate (TOCP), and then sacrificed at 1 day, 5 day, 10 day and 21 day post-exposure, respectively. Sciatic nerves and spinal cords were examined for pathological changes and proteins expression related to Wallerian-like degeneration and necroptosis. In vitro experiments using differentiated neuro-2a (N2a) cells were conducted to investigate the relationship among mit...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: Mingxue Song Kang Kang Shuai Wang Cuiqin Zhang Xiulan Zhao Fuyong Song Source Type: research
Ferroptosis is involved in trophoblast cells cytotoxicity induced by black phosphorus nanoparticles
Toxicology. 2024 Apr 21;505:153810. doi: 10.1016/j.tox.2024.153810. Online ahead of print.ABSTRACTBlack phosphorus (BP) is a new type of nanomaterial, which has been widely used in many biomedical fields due to its superior properties, but there are few studies on the toxicity of BP, especially in the reproductive system. To explore the effects of BP exposure on reproduction and reveal its molecular mechanism, we firstly investigated the potential toxicity of black phosphorus nanoparticles (BPNPs) in vivo. The results showed that BP exposure in pregnant mice can reduce the weight of fetal mice and placenta. H&E stainin...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: Ruolan You Yaming Mu Jiaqi Zhou Chunying Wang Zhenya Fang Yu Liu Shiyu Liu Qingfeng Zhai Changqing Zhang Source Type: research
Systematic literature review of heavy metal contamination of the Nigerian environment from E-waste management: associated health and carcinogenic risk assessment
This study harmonizes primary data on HMs from e-waste in different Nigerian environmental media including the air, soil, surface dust, water and plant. We estimated the possible health implications, single and aggregative soil and water pollution indices in adult and children, carcinogenic and non-carcinogenic risks secondary to HM exposure and mapped out the possible mechanism of carcinogenesis. Analysis showed that soil, water, surface dust and plant matrices in Nigerian environment are variedly but considerably contaminated with combination of HMs. The significantly high values of the hazard quotient and hazard index o...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: W M Owonikoko C G Alimba Source Type: research
Elevated intracellular Ca < sup > 2+ < /sup > functions downstream of mitodysfunction to induce Wallerian-like degeneration and necroptosis in organophosphorus-induced delayed neuropathy
This study was designed to investigate that deregulated cytosolic Ca2+ may function downstream of mitodysfunction in activating Wallerian-like degeneration and necroptosis in OPIDN. Adult hens were administrated a single dosage of 750 mg/kg tri-ortho-cresyl phosphate (TOCP), and then sacrificed at 1 day, 5 day, 10 day and 21 day post-exposure, respectively. Sciatic nerves and spinal cords were examined for pathological changes and proteins expression related to Wallerian-like degeneration and necroptosis. In vitro experiments using differentiated neuro-2a (N2a) cells were conducted to investigate the relationship among mit...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: Mingxue Song Kang Kang Shuai Wang Cuiqin Zhang Xiulan Zhao Fuyong Song Source Type: research
Ferroptosis is involved in human chorionic trophoblast cells cytotoxicity induced by black phosphorus nanoparticles
Toxicology. 2024 Apr 21:153810. doi: 10.1016/j.tox.2024.153810. Online ahead of print.ABSTRACTBlack phosphorus (BP) is a new type of nanomaterial, which has been widely used in many biomedical fields due to its superior properties, but there are few studies on the toxicity of BP, especially in the reproductive system. To explore the effects of BP exposure on reproduction and reveal its molecular mechanism, we firstly investigated the potential toxicity of black phosphorus nanoparticles (BPNPs) in vivo. The results showed that BP exposure in pregnant mice can reduce the weight of fetal mice and placenta. H&E staining fu...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: Ruolan You Yaming Mu Jiaqi Zhou Chunying Wang Zhenya Fang Yu Liu Shiyu Liu Qingfeng Zhai Changqing Zhang Source Type: research
Ferroptosis is involved in human chorionic trophoblast cells cytotoxicity induced by black phosphorus nanoparticles
Toxicology. 2024 Apr 21:153810. doi: 10.1016/j.tox.2024.153810. Online ahead of print.ABSTRACTBlack phosphorus (BP) is a new type of nanomaterial, which has been widely used in many biomedical fields due to its superior properties, but there are few studies on the toxicity of BP, especially in the reproductive system. To explore the effects of BP exposure on reproduction and reveal its molecular mechanism, we firstly investigated the potential toxicity of black phosphorus nanoparticles (BPNPs) in vivo. The results showed that BP exposure in pregnant mice can reduce the weight of fetal mice and placenta. H&E staining fu...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: Ruolan You Yaming Mu Jiaqi Zhou Chunying Wang Zhenya Fang Yu Liu Shiyu Liu Qingfeng Zhai Changqing Zhang Source Type: research
Systematic literature review of heavy metal contamination of the Nigerian environment from E-waste management: associated health and carcinogenic risk assessment
This study harmonizes primary data on HMs from e-waste in different Nigerian environmental media including the air, soil, surface dust, water and plant. We estimated the possible health implications, single and aggregative soil and water pollution indices in adult and children, carcinogenic and non-carcinogenic risks secondary to HM exposure and mapped out the possible mechanism of carcinogenesis. Analysis showed that soil, water, surface dust and plant matrices in Nigerian environment are variedly but considerably contaminated with combination of HMs. The significantly high values of the hazard quotient and hazard index o...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: W M Owonikoko C G Alimba Source Type: research
Elevated intracellular Ca < sup > 2+ < /sup > functions downstream of mitodysfunction to induce Wallerian-like degeneration and necroptosis in organophosphorus-induced delayed neuropathy
This study was designed to investigate that deregulated cytosolic Ca2+ may function downstream of mitodysfunction in activating Wallerian-like degeneration and necroptosis in OPIDN. Adult hens were administrated a single dosage of 750mg/kg tri-ortho-cresyl phosphate (TOCP), and then sacrificed at 1day, 5day, 10day and 21day post-exposure, respectively. Sciatic nerves and spinal cords were examined for pathological changes and proteins expression related to Wallerian-like degeneration and necroptosis. In vitro experiments using differentiated neuro-2a (N2a) cells were conducted to investigate the relationship among mitochon...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: Mingxue Song Kang Kang Shuai Wang Cuiqin Zhang Xiulan Zhao Fuyong Song Source Type: research
Lead exerts a depression of neurotransmitter release through a blockade of voltage dependent calcium channels in chromaffin cells
Toxicology. 2024 Apr 20:153809. doi: 10.1016/j.tox.2024.153809. Online ahead of print.ABSTRACTThe present work, using chromaffin cells of bovine adrenal medullae (BCCs), aims to describe what type of ionic current alterations induced by lead (Pb2+) underlies its effects reported on synaptic transmission. We observed that the acute application of Pb2+ lead to a drastic depression of neurotransmitters release in a concentration-dependent manner when the cells were stimulated with both K+ or acetylcholine, with an IC50 of 119,57 μM and of 5,19 μM, respectively. This effect was fully recovered after washout. Pb2+ also blocke...
Source: Toxicology - April 22, 2024 Category: Toxicology Authors: Victoria Jim énez Carretero Ninfa Liccardi Maria Arribas Tejedor Ricardo de Pascual Jorge Hern ández Campano Jes ús M Hernández-Guijo Source Type: research
Sex, Age, and Species Differences of Perfluorooctanoic Acid Modeled by Flow- versus Permeability-limited Physiologically-Based Pharmacokinetic Models
In conclusion, the permeability PBPK model could interpret age, sex, and species differences and it could improve the accuracy of human prediction.PMID:38642821 | DOI:10.1016/j.tox.2024.153806 (Source: Toxicology)
Source: Toxicology - April 20, 2024 Category: Toxicology Authors: Go-Wun Choi Dong Wook Kang Ju Hee Kim Seok-Jin Cho Yong-Bok Lee In-Ho Kwon Hea-Young Cho Source Type: research
