Single-cell and multi-omics analyses highlight cancer-associated fibroblasts-induced immune evasion and epithelial mesenchymal transition for smoking bladder cancer
Toxicology. 2024 Mar 15:153782. doi: 10.1016/j.tox.2024.153782. Online ahead of print.ABSTRACTTobacco carcinogens are recognized as critical hazard factors for bladder tumorigenesis, affecting the prognosis of patients through aromatic amines components. However, the specific function of tobacco carcinogens and systematic assessment models in the prognosis of bladder cancer remains poorly elucidated. We retrieved bladder cancer specific tobacco carcinogens-related genes from Comparative Toxicogenomic Database, our Nanjing Bladder Cancer cohort and TCGA database. Gene×gene interaction method was utilized to establish a pro...
Source: Toxicology - March 17, 2024 Category: Toxicology Authors: Jiajin Wu Fang Gao Rui Meng Huiqin Li Zhenguang Mao Yanping Xiao Qiuyi Pu Mulong Du Zhengdong Zhang Qiang Shao Rui Zheng Meilin Wang Source Type: research
A review on toxicity mechanism and risk factors of nanoparticles in respiratory tract
Toxicology. 2024 Mar 15:153781. doi: 10.1016/j.tox.2024.153781. Online ahead of print.ABSTRACTThis comprehensive review focuses on various dimensions of nanoparticle toxicity, emphasizing toxicological characteristics, assessment techniques, and examinations of relevant studies on the effects on biological systems. The primary objective is to comprehend the potential risks associated with nanoparticles and to provide efficient strategies for mitigating them by consolidating current research discoveries. For in-depth insights, the discussions extend to crucial aspects such as toxicity associated with different nanoparticles...
Source: Toxicology - March 17, 2024 Category: Toxicology Authors: Vidyasri Khadanga Purna Chandra Mishra Source Type: research
Single-cell and multi-omics analyses highlight cancer-associated fibroblasts-induced immune evasion and epithelial mesenchymal transition for smoking bladder cancer
Toxicology. 2024 Mar 15:153782. doi: 10.1016/j.tox.2024.153782. Online ahead of print.ABSTRACTTobacco carcinogens are recognized as critical hazard factors for bladder tumorigenesis, affecting the prognosis of patients through aromatic amines components. However, the specific function of tobacco carcinogens and systematic assessment models in the prognosis of bladder cancer remains poorly elucidated. We retrieved bladder cancer specific tobacco carcinogens-related genes from Comparative Toxicogenomic Database, our Nanjing Bladder Cancer cohort and TCGA database. Gene×gene interaction method was utilized to establish a pro...
Source: Toxicology - March 17, 2024 Category: Toxicology Authors: Jiajin Wu Fang Gao Rui Meng Huiqin Li Zhenguang Mao Yanping Xiao Qiuyi Pu Mulong Du Zhengdong Zhang Qiang Shao Rui Zheng Meilin Wang Source Type: research
A review on toxicity mechanism and risk factors of nanoparticles in respiratory tract
Toxicology. 2024 Mar 15:153781. doi: 10.1016/j.tox.2024.153781. Online ahead of print.ABSTRACTThis comprehensive review focuses on various dimensions of nanoparticle toxicity, emphasizing toxicological characteristics, assessment techniques, and examinations of relevant studies on the effects on biological systems. The primary objective is to comprehend the potential risks associated with nanoparticles and to provide efficient strategies for mitigating them by consolidating current research discoveries. For in-depth insights, the discussions extend to crucial aspects such as toxicity associated with different nanoparticles...
Source: Toxicology - March 17, 2024 Category: Toxicology Authors: Vidyasri Khadanga Purna Chandra Mishra Source Type: research
Metabolism-dependent mutagenicity of two structurally similar tobacco-specific nitrosamines (N-nitrosonornicotine and N-nitrosoanabasine) in human cells, partially different CYPs being activating enzymes
In this study, the chemical-CYP interaction was analyzed by molecular docking, thus the binding energies and conformations of NNN for human CYP2A6, 2A13, 2B6, 2E1 and 3A4 appeared appropriate as a substrate, so did NAB for human CYP1B1, 2A6, 2A13 and 2E1. The micronucleus test in human hepatoma (HepG2) cells with each compound (62.5-1000 μM) exposing for 48 h (two-cell cycle) was negative, however, pretreatment with bisphenol AF (0.1-100 nM, CYPs inducer) and ethanol (0.2% v:v, CYP2E1 inducer) potentiated micronucleus formation by both compounds, while CITCO (1 μM, CYP2B6 inducer) selectively potentiated that by NNN. In ...
Source: Toxicology - March 15, 2024 Category: Toxicology Authors: Yijing Chen Zongying Yang Zhao Zhou Ellery J Liu Wenwen Luo Zhini He Weili Han Yungang Liu Source Type: research
Metabolism-dependent mutagenicity of two structurally similar tobacco-specific nitrosamines (N-nitrosonornicotine and N-nitrosoanabasine) in human cells, partially different CYPs being activating enzymes
In this study, the chemical-CYP interaction was analyzed by molecular docking, thus the binding energies and conformations of NNN for human CYP2A6, 2A13, 2B6, 2E1 and 3A4 appeared appropriate as a substrate, so did NAB for human CYP1B1, 2A6, 2A13 and 2E1. The micronucleus test in human hepatoma (HepG2) cells with each compound (62.5-1000 μM) exposing for 48 h (two-cell cycle) was negative, however, pretreatment with bisphenol AF (0.1-100 nM, CYPs inducer) and ethanol (0.2% v:v, CYP2E1 inducer) potentiated micronucleus formation by both compounds, while CITCO (1 μM, CYP2B6 inducer) selectively potentiated that by NNN. In ...
Source: Toxicology - March 15, 2024 Category: Toxicology Authors: Yijing Chen Zongying Yang Zhao Zhou Ellery J Liu Wenwen Luo Zhini He Weili Han Yungang Liu Source Type: research
Genotoxic and cytotoxic effects of aflatoxin on the reproductive system: Focus on cell cycle dynamics and apoptosis in testicular tissue
Toxicology. 2024 Mar 12:153773. doi: 10.1016/j.tox.2024.153773. Online ahead of print.ABSTRACTAflatoxins (AFs) are inevitable environmental contaminants that are detrimental to human and animal health. AFs interfere with metabolic processes, metabolizing into different hydroxylated derivatives in the liver, as well as mechanistically induce ROS accumulation, S-phase arrest, DNA damage, and cell apoptosis. Chronic consumption of aflatoxin-contaminated foods can adversely affect the male reproductive system, cause testicular damage, prevent testosterone synthesis, decline sperm quality, and cause infertility. Oxidative stres...
Source: Toxicology - March 14, 2024 Category: Toxicology Authors: Cyrus Jalili Rahele Ranjbar Shamsi Bita Amiri Seyran Kakebaraie Faramarz Jalili Touraj Zamir Nasta Source Type: research
Genotoxic and cytotoxic effects of aflatoxin on the reproductive system: Focus on cell cycle dynamics and apoptosis in testicular tissue
Toxicology. 2024 Mar 12:153773. doi: 10.1016/j.tox.2024.153773. Online ahead of print.ABSTRACTAflatoxins (AFs) are inevitable environmental contaminants that are detrimental to human and animal health. AFs interfere with metabolic processes, metabolizing into different hydroxylated derivatives in the liver, as well as mechanistically induce ROS accumulation, S-phase arrest, DNA damage, and cell apoptosis. Chronic consumption of aflatoxin-contaminated foods can adversely affect the male reproductive system, cause testicular damage, prevent testosterone synthesis, decline sperm quality, and cause infertility. Oxidative stres...
Source: Toxicology - March 14, 2024 Category: Toxicology Authors: Cyrus Jalili Rahele Ranjbar Shamsi Bita Amiri Seyran Kakebaraie Faramarz Jalili Touraj Zamir Nasta Source Type: research
Metabolic alterations and mitochondrial dysfunction in human airway BEAS-2B cells exposed to vanadium pentoxide
In this study, we investigated the metabolic response of human bronchial epithelial BEAS-2B cells to low-level V+5 exposure (0.01, 0.1, and 1 ppm) using liquid chromatography-high resolution mass spectrometry (LC-HRMS). Exposure to V+5 caused extensive changes to cellular metabolism in BEAS-2B cells, including TCA cycle, glycolysis, fatty acids, amino acids, amino sugars, nucleotide sugar, sialic acid, vitamin D3, and drug metabolism, without causing cell death. Altered mitochondrial structure and function, and disruption in glycolysis were observed with as low as 0.01 ppm (0.2 μM) V+5 exposure. In addition, decreased lev...
Source: Toxicology - March 13, 2024 Category: Toxicology Authors: Xiaojia He Matthew Ryan Smith Zachery R Jarrell ViLinh Thi Ly Yongliang Liang Choon-Myung Lee Michael Orr Young-Mi Go Dean P Jones Source Type: research
Metabolic alterations and mitochondrial dysfunction in human airway BEAS-2B cells exposed to vanadium pentoxide
In this study, we investigated the metabolic response of human bronchial epithelial BEAS-2B cells to low-level V+5 exposure (0.01, 0.1, and 1 ppm) using liquid chromatography-high resolution mass spectrometry (LC-HRMS). Exposure to V+5 caused extensive changes to cellular metabolism in BEAS-2B cells, including TCA cycle, glycolysis, fatty acids, amino acids, amino sugars, nucleotide sugar, sialic acid, vitamin D3, and drug metabolism, without causing cell death. Altered mitochondrial structure and function, and disruption in glycolysis were observed with as low as 0.01 ppm (0.2 μM) V+5 exposure. In addition, decreased lev...
Source: Toxicology - March 13, 2024 Category: Toxicology Authors: Xiaojia He Matthew Ryan Smith Zachery R Jarrell ViLinh Thi Ly Yongliang Liang Choon-Myung Lee Michael Orr Young-Mi Go Dean P Jones Source Type: research
Prediction of Acute Methanol Poisoning Prognosis Using machine learning techniques
This study focuses on predicting the severity of methanol intoxication using machine learning techniques, aiming to improve early identification and prognosis assessment. The study, conducted at Loghman Hakim Hospital in Tehran, Iran. The data pertaining to individuals afflicted with methanol poisoning was retrieved retrospectively and divided into training and test groups at a ratio of 70:30. The selected features were then inputted into various machine learning methods. The models were implemented using the Scikit-learn library in the Python programming language. Ultimately, the efficacy of the developed models was asses...
Source: Toxicology - March 8, 2024 Category: Toxicology Authors: Mitra Rahimi Sayed Masoud Hosseini Seyed Ali Mohtarami Babak Mostafazadeh Peyman Erfan Talab Evini Mobin Fathy Arya Kazemi Sina Khani Seyed Mohammad Mortazavi Amirali Soheili Seyed Mohammad Vahabi Shahin Shadnia Source Type: research
Prediction of Acute Methanol Poisoning Prognosis Using machine learning techniques
This study focuses on predicting the severity of methanol intoxication using machine learning techniques, aiming to improve early identification and prognosis assessment. The study, conducted at Loghman Hakim Hospital in Tehran, Iran. The data pertaining to individuals afflicted with methanol poisoning was retrieved retrospectively and divided into training and test groups at a ratio of 70:30. The selected features were then inputted into various machine learning methods. The models were implemented using the Scikit-learn library in the Python programming language. Ultimately, the efficacy of the developed models was asses...
Source: Toxicology - March 8, 2024 Category: Toxicology Authors: Mitra Rahimi Sayed Masoud Hosseini Seyed Ali Mohtarami Babak Mostafazadeh Peyman Erfan Talab Evini Mobin Fathy Arya Kazemi Sina Khani Seyed Mohammad Mortazavi Amirali Soheili Seyed Mohammad Vahabi Shahin Shadnia Source Type: research
Prediction of Acute Methanol Poisoning Prognosis Using machine learning techniques
This study focuses on predicting the severity of methanol intoxication using machine learning techniques, aiming to improve early identification and prognosis assessment. The study, conducted at Loghman Hakim Hospital in Tehran, Iran. The data pertaining to individuals afflicted with methanol poisoning was retrieved retrospectively and divided into training and test groups at a ratio of 70:30. The selected features were then inputted into various machine learning methods. The models were implemented using the Scikit-learn library in the Python programming language. Ultimately, the efficacy of the developed models was asses...
Source: Toxicology - March 8, 2024 Category: Toxicology Authors: Mitra Rahimi Sayed Masoud Hosseini Seyed Ali Mohtarami Babak Mostafazadeh Peyman Erfan Talab Evini Mobin Fathy Arya Kazemi Sina Khani Seyed Mohammad Mortazavi Amirali Soheili Seyed Mohammad Vahabi Shahin Shadnia Source Type: research
Prediction of Acute Methanol Poisoning Prognosis Using machine learning techniques
This study focuses on predicting the severity of methanol intoxication using machine learning techniques, aiming to improve early identification and prognosis assessment. The study, conducted at Loghman Hakim Hospital in Tehran, Iran. The data pertaining to individuals afflicted with methanol poisoning was retrieved retrospectively and divided into training and test groups at a ratio of 70:30. The selected features were then inputted into various machine learning methods. The models were implemented using the Scikit-learn library in the Python programming language. Ultimately, the efficacy of the developed models was asses...
Source: Toxicology - March 8, 2024 Category: Toxicology Authors: Mitra Rahimi Sayed Masoud Hosseini Seyed Ali Mohtarami Babak Mostafazadeh Peyman Erfan Talab Evini Mobin Fathy Arya Kazemi Sina Khani Seyed Mohammad Mortazavi Amirali Soheili Seyed Mohammad Vahabi Shahin Shadnia Source Type: research
Influence of lead-induced toxicity on the inflammatory cytokines
Toxicology. 2024 Mar 5:153771. doi: 10.1016/j.tox.2024.153771. Online ahead of print.ABSTRACTLead (Pb2+) is a hazardous heavy metal that is pervasive in the human environment as a result of anthropogenic activity, and poses serious health risks, particularly in children. Due to its innumerable unique physical and chemical properties, it has various applications; therefore, it has become a common environmental pollutant. Lead may cause oxidative stress, and accumulating evidence indicates that oxidative stress influences the pathophysiology of lead poisoning, also called plumbism. The immune system is continually exposed to...
Source: Toxicology - March 7, 2024 Category: Toxicology Authors: P Harshitha Kalpita Bose Herman Sunil Dsouza Source Type: research
