In Vitro Binding Analysis of Legacy-Linear and New Generation-Cyclic Perfluoro-Alkyl Substances on Sex Hormone Binding Globulin and Albumin, Suggests Low Impact on Serum Hormone Kinetics of Testosterone
Toxicology. 2023 Nov 4:153664. doi: 10.1016/j.tox.2023.153664. Online ahead of print.ABSTRACTIn humans, serum testosterone (T) is largely bound to the sex hormone binding globulin (SHBG) and human serum albumin (hSA), resulting in a 2-3% of unbound or "free" active quote (FT). Endocrine-disrupting chemicals, including perfluoro-alkyl substances (PFAS), are recognized to interfere with the hormonal axes, but the possible impact on the FT quote has not been addressed so far. Here we investigated the possible competition of two acknowledged PFAS molecules on T binding to SHBG and hSA. In particular, perfluoro-octanoic acid (P...
Source: Toxicology - November 6, 2023 Category: Toxicology Authors: Angela Pavan Laura Cendron Andrea Di Nisio Federica Pedrucci Iva Sabovic Alessandro Scarso Alberto Ferlin Alessandro Angelini Carlo Foresta Luca De Toni Source Type: research
In Vitro Binding Analysis of Legacy-Linear and New Generation-Cyclic Perfluoro-Alkyl Substances on Sex Hormone Binding Globulin and Albumin, Suggests Low Impact on Serum Hormone Kinetics of Testosterone
Toxicology. 2023 Nov 4:153664. doi: 10.1016/j.tox.2023.153664. Online ahead of print.ABSTRACTIn humans, serum testosterone (T) is largely bound to the sex hormone binding globulin (SHBG) and human serum albumin (hSA), resulting in a 2-3% of unbound or "free" active quote (FT). Endocrine-disrupting chemicals, including perfluoro-alkyl substances (PFAS), are recognized to interfere with the hormonal axes, but the possible impact on the FT quote has not been addressed so far. Here we investigated the possible competition of two acknowledged PFAS molecules on T binding to SHBG and hSA. In particular, perfluoro-octanoic acid (P...
Source: Toxicology - November 6, 2023 Category: Toxicology Authors: Angela Pavan Laura Cendron Andrea Di Nisio Federica Pedrucci Iva Sabovic Alessandro Scarso Alberto Ferlin Alessandro Angelini Carlo Foresta Luca De Toni Source Type: research
Considerations for future quantitative structure-activity relationship (QSAR) modelling for heavy metals - A case study of mercury
Toxicology. 2023 Nov 2:153661. doi: 10.1016/j.tox.2023.153661. Online ahead of print.ABSTRACTWith increasing annual chemical development and production, safety testing demands and requirements have also increased. In addition to traditional animal testing, quantitative structure-activity relationship (QSAR) modelling can be used to predict the biological effect of a chemical structure, based on the analysis of quantitative characteristics of structure features. Whilst suitable for e.g., pharmaceuticals, other compounds can be more challenging to model. The naturally occurring heavy metal mercury speciates in the environmen...
Source: Toxicology - November 4, 2023 Category: Toxicology Authors: Rebecca von Hellfeld Christoph Gade Neil Vargesson Astley Hastings Source Type: research
Genotoxicity assessment of 1,4-Anhydro-4-seleno-D-talitol (SeTal) in human liver HepG2 and HepaRG cells
Toxicology. 2023 Nov 2:153663. doi: 10.1016/j.tox.2023.153663. Online ahead of print.ABSTRACT1,4-Anhydro-4-seleno-D-talitol (SeTal) is a highly water-soluble selenosugar with interesting antioxidant and skin-tissue-repair properties; it is highly stable in simulated gastric and gastrointestinal fluids and is a potential pharmaceutical ingredient that may be administered orally. Hepatic toxicity is often a major problem with novel drugs and can result in drug withdrawal from the market. Predicting hepatotoxicity is therefore essential to minimize late failure in the drug-discovery process. Herein, we report in vitro studies...
Source: Toxicology - November 4, 2023 Category: Toxicology Authors: Raffaella di Vito Mattia Acito Cristina Fatigoni Carl H Schiesser Michael J Davies Francesca Mangiavacchi Milena Villarini Claudio Santi Massimo Moretti Source Type: research
Non-coding RNAs: A new frontier in Benzene-mediated toxicity
Toxicology. 2023 Nov 2:153660. doi: 10.1016/j.tox.2023.153660. Online ahead of print.ABSTRACTOne of the most frequent environmental contaminants, benzene is still widely used as an industrial solvent around the world, especially in developing nations, posing a serious occupational risk. While the processes behind the toxicity of benzene grounds are not fully understood, it is generally accepted that its metabolism, which involves one or more reactive metabolites, is crucial to its toxicity. In order to evaluate the many ways that benzene could influence gene regulation and thus have an impact on human health, new methodolo...
Source: Toxicology - November 4, 2023 Category: Toxicology Authors: Amir Hosein Sanjari Nia Mehran Reyhani-Ardabili Maryam Sheikhvand Saeid Bagheri-Mohammadi Hadi Niknejad Hassan Rasoulzadeh Abolfazl Movafagh Sam Kharazi Neghad Mohammad Baniasadi Ahad Ashraf-Asgarabad Mobina Hosseini Seyed Mohsen Aghaei-Zarch Source Type: research
Considerations for future quantitative structure-activity relationship (QSAR) modelling for heavy metals - A case study of mercury
Toxicology. 2023 Nov 2:153661. doi: 10.1016/j.tox.2023.153661. Online ahead of print.ABSTRACTWith increasing annual chemical development and production, safety testing demands and requirements have also increased. In addition to traditional animal testing, quantitative structure-activity relationship (QSAR) modelling can be used to predict the biological effect of a chemical structure, based on the analysis of quantitative characteristics of structure features. Whilst suitable for e.g., pharmaceuticals, other compounds can be more challenging to model. The naturally occurring heavy metal mercury speciates in the environmen...
Source: Toxicology - November 4, 2023 Category: Toxicology Authors: Rebecca von Hellfeld Christoph Gade Neil Vargesson Astley Hastings Source Type: research
Genotoxicity assessment of 1,4-Anhydro-4-seleno-D-talitol (SeTal) in human liver HepG2 and HepaRG cells
Toxicology. 2023 Nov 2:153663. doi: 10.1016/j.tox.2023.153663. Online ahead of print.ABSTRACT1,4-Anhydro-4-seleno-D-talitol (SeTal) is a highly water-soluble selenosugar with interesting antioxidant and skin-tissue-repair properties; it is highly stable in simulated gastric and gastrointestinal fluids and is a potential pharmaceutical ingredient that may be administered orally. Hepatic toxicity is often a major problem with novel drugs and can result in drug withdrawal from the market. Predicting hepatotoxicity is therefore essential to minimize late failure in the drug-discovery process. Herein, we report in vitro studies...
Source: Toxicology - November 4, 2023 Category: Toxicology Authors: Raffaella di Vito Mattia Acito Cristina Fatigoni Carl H Schiesser Michael J Davies Francesca Mangiavacchi Milena Villarini Claudio Santi Massimo Moretti Source Type: research
Non-coding RNAs: A new frontier in Benzene-mediated toxicity
Toxicology. 2023 Nov 2:153660. doi: 10.1016/j.tox.2023.153660. Online ahead of print.ABSTRACTOne of the most frequent environmental contaminants, benzene is still widely used as an industrial solvent around the world, especially in developing nations, posing a serious occupational risk. While the processes behind the toxicity of benzene grounds are not fully understood, it is generally accepted that its metabolism, which involves one or more reactive metabolites, is crucial to its toxicity. In order to evaluate the many ways that benzene could influence gene regulation and thus have an impact on human health, new methodolo...
Source: Toxicology - November 4, 2023 Category: Toxicology Authors: Amir Hosein Sanjari Nia Mehran Reyhani-Ardabili Maryam Sheikhvand Saeid Bagheri-Mohammadi Hadi Niknejad Hassan Rasoulzadeh Abolfazl Movafagh Sam Kharazi Neghad Mohammad Baniasadi Ahad Ashraf-Asgarabad Mobina Hosseini Seyed Mohsen Aghaei-Zarch Source Type: research
Considerations for future quantitative structure-activity relationship (QSAR) modelling for heavy metals - A case study of mercury
Toxicology. 2023 Nov 2:153661. doi: 10.1016/j.tox.2023.153661. Online ahead of print.ABSTRACTWith increasing annual chemical development and production, safety testing demands and requirements have also increased. In addition to traditional animal testing, quantitative structure-activity relationship (QSAR) modelling can be used to predict the biological effect of a chemical structure, based on the analysis of quantitative characteristics of structure features. Whilst suitable for e.g., pharmaceuticals, other compounds can be more challenging to model. The naturally occurring heavy metal mercury speciates in the environmen...
Source: Toxicology - November 4, 2023 Category: Toxicology Authors: Rebecca von Hellfeld Christoph Gade Neil Vargesson Astley Hastings Source Type: research
Genotoxicity assessment of 1,4-Anhydro-4-seleno-D-talitol (SeTal) in human liver HepG2 and HepaRG cells
Toxicology. 2023 Nov 2:153663. doi: 10.1016/j.tox.2023.153663. Online ahead of print.ABSTRACT1,4-Anhydro-4-seleno-D-talitol (SeTal) is a highly water-soluble selenosugar with interesting antioxidant and skin-tissue-repair properties; it is highly stable in simulated gastric and gastrointestinal fluids and is a potential pharmaceutical ingredient that may be administered orally. Hepatic toxicity is often a major problem with novel drugs and can result in drug withdrawal from the market. Predicting hepatotoxicity is therefore essential to minimize late failure in the drug-discovery process. Herein, we report in vitro studies...
Source: Toxicology - November 4, 2023 Category: Toxicology Authors: Raffaella di Vito Mattia Acito Cristina Fatigoni Carl H Schiesser Michael J Davies Francesca Mangiavacchi Milena Villarini Claudio Santi Massimo Moretti Source Type: research
Non-coding RNAs: A new frontier in Benzene-mediated toxicity
Toxicology. 2023 Nov 2:153660. doi: 10.1016/j.tox.2023.153660. Online ahead of print.ABSTRACTOne of the most frequent environmental contaminants, benzene is still widely used as an industrial solvent around the world, especially in developing nations, posing a serious occupational risk. While the processes behind the toxicity of benzene grounds are not fully understood, it is generally accepted that its metabolism, which involves one or more reactive metabolites, is crucial to its toxicity. In order to evaluate the many ways that benzene could influence gene regulation and thus have an impact on human health, new methodolo...
Source: Toxicology - November 4, 2023 Category: Toxicology Authors: Amir Hosein Sanjari Nia Mehran Reyhani-Ardabili Maryam Sheikhvand Saeid Bagheri-Mohammadi Hadi Niknejad Hassan Rasoulzadeh Abolfazl Movafagh Sam Kharazi Neghad Mohammad Baniasadi Ahad Ashraf-Asgarabad Mobina Hosseini Seyed Mohsen Aghaei-Zarch Source Type: research
Etoricoxib enhances aryl hydrocarbon receptor activity
Toxicology. 2023 Oct 25:153658. doi: 10.1016/j.tox.2023.153658. Online ahead of print.ABSTRACTEtoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that possesses properties that include reducing inflammation and relieving pain and fever. Etoricoxib is an oral medication that selectively inhibits cyclooxygenase-2 with high efficacy. Controversies about its cardiovascular side effects have long existed. The aryl hydrocarbon receptor (AhR) is a cytoplasmic receptor that plays a key role in the metabolism of xenobiotics and many physiological functions. 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester ...
Source: Toxicology - October 27, 2023 Category: Toxicology Authors: Hsiao-Ho Fang Jiun Hsu Jyan-Gwo Joseph Su Source Type: research
Etoricoxib enhances aryl hydrocarbon receptor activity
Toxicology. 2023 Oct 25:153658. doi: 10.1016/j.tox.2023.153658. Online ahead of print.ABSTRACTEtoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that possesses properties that include reducing inflammation and relieving pain and fever. Etoricoxib is an oral medication that selectively inhibits cyclooxygenase-2 with high efficacy. Controversies about its cardiovascular side effects have long existed. The aryl hydrocarbon receptor (AhR) is a cytoplasmic receptor that plays a key role in the metabolism of xenobiotics and many physiological functions. 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester ...
Source: Toxicology - October 27, 2023 Category: Toxicology Authors: Hsiao-Ho Fang Jiun Hsu Jyan-Gwo Joseph Su Source Type: research
Etoricoxib enhances aryl hydrocarbon receptor activity
Toxicology. 2023 Oct 25:153658. doi: 10.1016/j.tox.2023.153658. Online ahead of print.ABSTRACTEtoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that possesses properties that include reducing inflammation and relieving pain and fever. Etoricoxib is an oral medication that selectively inhibits cyclooxygenase-2 with high efficacy. Controversies about its cardiovascular side effects have long existed. The aryl hydrocarbon receptor (AhR) is a cytoplasmic receptor that plays a key role in the metabolism of xenobiotics and many physiological functions. 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester ...
Source: Toxicology - October 27, 2023 Category: Toxicology Authors: Hsiao-Ho Fang Jiun Hsu Jyan-Gwo Joseph Su Source Type: research
Etoricoxib enhances aryl hydrocarbon receptor activity
Toxicology. 2023 Oct 25:153658. doi: 10.1016/j.tox.2023.153658. Online ahead of print.ABSTRACTEtoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that possesses properties that include reducing inflammation and relieving pain and fever. Etoricoxib is an oral medication that selectively inhibits cyclooxygenase-2 with high efficacy. Controversies about its cardiovascular side effects have long existed. The aryl hydrocarbon receptor (AhR) is a cytoplasmic receptor that plays a key role in the metabolism of xenobiotics and many physiological functions. 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester ...
Source: Toxicology - October 27, 2023 Category: Toxicology Authors: Hsiao-Ho Fang Jiun Hsu Jyan-Gwo Joseph Su Source Type: research
