Non-coding RNAs: A new frontier in Benzene-mediated toxicity

Toxicology. 2023 Nov 2:153660. doi: 10.1016/j.tox.2023.153660. Online ahead of print.ABSTRACTOne of the most frequent environmental contaminants, benzene is still widely used as an industrial solvent around the world, especially in developing nations, posing a serious occupational risk. While the processes behind the toxicity of benzene grounds are not fully understood, it is generally accepted that its metabolism, which involves one or more reactive metabolites, is crucial to its toxicity. In order to evaluate the many ways that benzene could influence gene regulation and thus have an impact on human health, new methodologies have been created. The pathophysiology of the disorder may result from epigenetic reprogramming caused by exposure to benzene, including changes in non-coding RNA (ncRNA) markers, according to recent studies. We are interested in the identification of hazardous regulatory ncRNAs, the identification of these ncRNAs' targets, and the comprehension of the significance of these interactions in the mechanisms behind benzene toxicity. Hence, the focus of recent research is on long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs), and some of the more pertinent articles are also discussed.PMID:37924934 | DOI:10.1016/j.tox.2023.153660

Source: Toxicology - November 4, 2023 Category: Toxicology Authors: Amir Hosein Sanjari Nia Mehran Reyhani-Ardabili Maryam Sheikhvand Saeid Bagheri-Mohammadi Hadi Niknejad Hassan Rasoulzadeh Abolfazl Movafagh Sam Kharazi Neghad Mohammad Baniasadi Ahad Ashraf-Asgarabad Mobina Hosseini Seyed Mohsen Aghaei-Zarch Source Type: research