Cuproptosis-Associated Hub Gene Identification and Immune Cell Infiltration Patterns in Silicosis
Toxicology. 2024 Feb 23:153762. doi: 10.1016/j.tox.2024.153762. Online ahead of print.ABSTRACTRecent research has hinted at a potential connection between silicosis, a fibrotic lung disease caused by exposure to crystalline silica particles, and cuproptosis. The aim of the study was to explore how cuproptosis-related genes (CRGs) may influence the development of silicosis and elucidate the underlying mechanisms. An analysis of genes associated with both silicosis and cuproptosis was conducted. Key gene identification was achieved through the application of two machine learning techniques. Additionally, the correlation betw...
Source: Toxicology - February 25, 2024 Category: Toxicology Authors: Ruimin Ma Di Sun Yuanying Wang Xiaoxi Huang Qiao Ye Source Type: research
Cuproptosis-Associated Hub Gene Identification and Immune Cell Infiltration Patterns in Silicosis
Toxicology. 2024 Feb 23:153762. doi: 10.1016/j.tox.2024.153762. Online ahead of print.ABSTRACTRecent research has hinted at a potential connection between silicosis, a fibrotic lung disease caused by exposure to crystalline silica particles, and cuproptosis. The aim of the study was to explore how cuproptosis-related genes (CRGs) may influence the development of silicosis and elucidate the underlying mechanisms. An analysis of genes associated with both silicosis and cuproptosis was conducted. Key gene identification was achieved through the application of two machine learning techniques. Additionally, the correlation betw...
Source: Toxicology - February 25, 2024 Category: Toxicology Authors: Ruimin Ma Di Sun Yuanying Wang Xiaoxi Huang Qiao Ye Source Type: research
Recreational MDMA doses do not elicit hepatotoxicity in HepG2 spheroids under normo- and hyperthermia
Toxicology. 2024 Feb 22:153761. doi: 10.1016/j.tox.2024.153761. Online ahead of print.ABSTRACTMDMA (3,4-methylenedioxymethamphetamine), an entactogen with empathogenic and prosocial effects, is widely used in music festivals and other festive settings. High MDMA doses have been associated with drug-induced liver injury and cases of hyperthermia. Although the latter condition is thought to increase MDMA hepatotoxicity, this correlation remains poorly explored for recreational MDMA doses. On the other hand, the fact that MDMA acts to extinguish fear and to reconsolidate memory could be explored as an adjunct to psychotherapy...
Source: Toxicology - February 24, 2024 Category: Toxicology Authors: Arthur L de Oliveira Raul G Miranda Daniel J Dorta Source Type: research
Insights into the Mechanism of Transcription Factors in Pb < sup > 2+ < /sup > -Induced Apoptosis
Toxicology. 2024 Feb 20:153760. doi: 10.1016/j.tox.2024.153760. Online ahead of print.ABSTRACTThe health risks associated with exposure to heavy metals, such as Pb2+, are increasingly concerning the public. Pb2+ can cause significant harm to the human body through oxidative stress, autophagy, inflammation, and DNA damage, disrupting cellular homeostasis and ultimately leading to cell death. Among these mechanisms, apoptosis is considered crucial. It has been confirmed that transcription factors play a central role as mediators during the apoptosis process. Interestingly, these transcription factors have different effects o...
Source: Toxicology - February 22, 2024 Category: Toxicology Authors: Jingchong Guo Ruikang Li Zhuqing Ouyang Jiawen Tang Wei Zhang Hui Chen Qian Zhu Jing Zhang Gaochun Zhu Source Type: research
Insights into the Mechanism of Transcription Factors in Pb < sup > 2+ < /sup > -Induced Apoptosis
Toxicology. 2024 Feb 20:153760. doi: 10.1016/j.tox.2024.153760. Online ahead of print.ABSTRACTThe health risks associated with exposure to heavy metals, such as Pb2+, are increasingly concerning the public. Pb2+ can cause significant harm to the human body through oxidative stress, autophagy, inflammation, and DNA damage, disrupting cellular homeostasis and ultimately leading to cell death. Among these mechanisms, apoptosis is considered crucial. It has been confirmed that transcription factors play a central role as mediators during the apoptosis process. Interestingly, these transcription factors have different effects o...
Source: Toxicology - February 22, 2024 Category: Toxicology Authors: Jingchong Guo Ruikang Li Zhuqing Ouyang Jiawen Tang Wei Zhang Hui Chen Qian Zhu Jing Zhang Gaochun Zhu Source Type: research
Insights into the Mechanism of Transcription Factors in Pb < sup > 2+ < /sup > -Induced Apoptosis
Toxicology. 2024 Feb 20:153760. doi: 10.1016/j.tox.2024.153760. Online ahead of print.ABSTRACTThe health risks associated with exposure to heavy metals, such as Pb2+, are increasingly concerning the public. Pb2+ can cause significant harm to the human body through oxidative stress, autophagy, inflammation, and DNA damage, disrupting cellular homeostasis and ultimately leading to cell death. Among these mechanisms, apoptosis is considered crucial. It has been confirmed that transcription factors play a central role as mediators during the apoptosis process. Interestingly, these transcription factors have different effects o...
Source: Toxicology - February 22, 2024 Category: Toxicology Authors: Jingchong Guo Ruikang Li Zhuqing Ouyang Jiawen Tang Wei Zhang Hui Chen Qian Zhu Jing Zhang Gaochun Zhu Source Type: research
Characterization and applicability of a novel physiologically relevant 3D-tetraculture bronchial model for in vitro assessment of respiratory sensitization
Toxicology. 2024 Feb 16:153756. doi: 10.1016/j.tox.2024.153756. Online ahead of print.ABSTRACTChemical Respiratory Allergy (CRA) is triggered after exposure to Low Molecular Weight (LMW) sensitizers and manifests clinically as asthma and rhinitis. From a risk/toxicity assessment point of view, there are few methods, none of them validated, for evaluating the respiratory sensitization potential of chemicals once the in vivo-based models usually employed for inhalation toxicity addressment do not comprise allergenicity endpoints specifically. Based on that, we developed, characterized, and evaluated the applicability of a 3D...
Source: Toxicology - February 18, 2024 Category: Toxicology Authors: Artur Christian Garcia da Silva Izadora Caroline Furtado de Mendon ça Marize Campos Valadares Source Type: research
Exposure to TCBPA stimulates the growth of arterial smooth muscle cells through the activation of the ROS/NF- κB/NLRP3 signaling pathway
In this study, the biological impact of TCBPA on arterial smooth muscle cells (ASMCs) was investigated. CCK8 and EdU assays demonstrated significant proliferation of ASMCs following TCBPA treatment. Furthermore, TCBPA induced an inflammatory response in smooth muscle cells, as evidenced by the upregulated expression of inflammatory cytokines including IL-6, IL-1β, and MCP1. Additionally, we observed that TCBPA triggered an oxidative stress response in ASMCs by measuring ROS levels. To elucidate the underlying molecular mechanism of TCBPA-induced ASMC proliferation, we found that NLRP3 was essential for this process. Furth...
Source: Toxicology - February 18, 2024 Category: Toxicology Authors: Huanyu Qiao Bo Yang Xiaoshuo Lv Yongmin Liu Source Type: research
Multiple organs injury and myocardial energy metabolism disorders induced by isoproterenol
Toxicology. 2024 Feb 16:153752. doi: 10.1016/j.tox.2024.153752. Online ahead of print.ABSTRACTThe study sought to assess the detrimental effects of isoproterenol (ISO) on major organs and investigate the potential reversibility of these adverse reactions in mice. Male mice were divided into normal control, 0.2mg/kg.d and 3.0mg/kg.d ISO groups, and were subcutaneously administered of the respective doses for 14 consecutive days. Subsequently, a recovery period experiment was conducted, replicating the aforementioned procedure, followed by an additional 2-week recovery period for the mice. Following 14 consecutive days of ad...
Source: Toxicology - February 18, 2024 Category: Toxicology Authors: Xiao-Ting Zhang Xu Zhang Meng-Wei Wang Chen Zhang Rui Weng Xu Xu Zu-Xi Gu Jian-Ping Gao Source Type: research
Characterization and applicability of a novel physiologically relevant 3D-tetraculture bronchial model for in vitro assessment of respiratory sensitization
Toxicology. 2024 Feb 16:153756. doi: 10.1016/j.tox.2024.153756. Online ahead of print.ABSTRACTChemical Respiratory Allergy (CRA) is triggered after exposure to Low Molecular Weight (LMW) sensitizers and manifests clinically as asthma and rhinitis. From a risk/toxicity assessment point of view, there are few methods, none of them validated, for evaluating the respiratory sensitization potential of chemicals once the in vivo-based models usually employed for inhalation toxicity addressment do not comprise allergenicity endpoints specifically. Based on that, we developed, characterized, and evaluated the applicability of a 3D...
Source: Toxicology - February 18, 2024 Category: Toxicology Authors: Artur Christian Garcia da Silva Izadora Caroline Furtado de Mendon ça Marize Campos Valadares Source Type: research
Exposure to TCBPA stimulates the growth of arterial smooth muscle cells through the activation of the ROS/NF- κB/NLRP3 signaling pathway
In this study, the biological impact of TCBPA on arterial smooth muscle cells (ASMCs) was investigated. CCK8 and EdU assays demonstrated significant proliferation of ASMCs following TCBPA treatment. Furthermore, TCBPA induced an inflammatory response in smooth muscle cells, as evidenced by the upregulated expression of inflammatory cytokines including IL-6, IL-1β, and MCP1. Additionally, we observed that TCBPA triggered an oxidative stress response in ASMCs by measuring ROS levels. To elucidate the underlying molecular mechanism of TCBPA-induced ASMC proliferation, we found that NLRP3 was essential for this process. Furth...
Source: Toxicology - February 18, 2024 Category: Toxicology Authors: Huanyu Qiao Bo Yang Xiaoshuo Lv Yongmin Liu Source Type: research
Multiple organs injury and myocardial energy metabolism disorders induced by isoproterenol
Toxicology. 2024 Feb 16:153752. doi: 10.1016/j.tox.2024.153752. Online ahead of print.ABSTRACTThe study sought to assess the detrimental effects of isoproterenol (ISO) on major organs and investigate the potential reversibility of these adverse reactions in mice. Male mice were divided into normal control, 0.2mg/kg.d and 3.0mg/kg.d ISO groups, and were subcutaneously administered of the respective doses for 14 consecutive days. Subsequently, a recovery period experiment was conducted, replicating the aforementioned procedure, followed by an additional 2-week recovery period for the mice. Following 14 consecutive days of ad...
Source: Toxicology - February 18, 2024 Category: Toxicology Authors: Xiao-Ting Zhang Xu Zhang Meng-Wei Wang Chen Zhang Rui Weng Xu Xu Zu-Xi Gu Jian-Ping Gao Source Type: research
Characterization and applicability of a novel physiologically relevant 3D-tetraculture bronchial model for in vitro assessment of respiratory sensitization
Toxicology. 2024 Feb 16:153756. doi: 10.1016/j.tox.2024.153756. Online ahead of print.ABSTRACTChemical Respiratory Allergy (CRA) is triggered after exposure to Low Molecular Weight (LMW) sensitizers and manifests clinically as asthma and rhinitis. From a risk/toxicity assessment point of view, there are few methods, none of them validated, for evaluating the respiratory sensitization potential of chemicals once the in vivo-based models usually employed for inhalation toxicity addressment do not comprise allergenicity endpoints specifically. Based on that, we developed, characterized, and evaluated the applicability of a 3D...
Source: Toxicology - February 18, 2024 Category: Toxicology Authors: Artur Christian Garcia da Silva Izadora Caroline Furtado de Mendon ça Marize Campos Valadares Source Type: research
Exposure to TCBPA stimulates the growth of arterial smooth muscle cells through the activation of the ROS/NF- κB/NLRP3 signaling pathway
In this study, the biological impact of TCBPA on arterial smooth muscle cells (ASMCs) was investigated. CCK8 and EdU assays demonstrated significant proliferation of ASMCs following TCBPA treatment. Furthermore, TCBPA induced an inflammatory response in smooth muscle cells, as evidenced by the upregulated expression of inflammatory cytokines including IL-6, IL-1β, and MCP1. Additionally, we observed that TCBPA triggered an oxidative stress response in ASMCs by measuring ROS levels. To elucidate the underlying molecular mechanism of TCBPA-induced ASMC proliferation, we found that NLRP3 was essential for this process. Furth...
Source: Toxicology - February 18, 2024 Category: Toxicology Authors: Huanyu Qiao Bo Yang Xiaoshuo Lv Yongmin Liu Source Type: research
Multiple organs injury and myocardial energy metabolism disorders induced by isoproterenol
Toxicology. 2024 Feb 16:153752. doi: 10.1016/j.tox.2024.153752. Online ahead of print.ABSTRACTThe study sought to assess the detrimental effects of isoproterenol (ISO) on major organs and investigate the potential reversibility of these adverse reactions in mice. Male mice were divided into normal control, 0.2mg/kg.d and 3.0mg/kg.d ISO groups, and were subcutaneously administered of the respective doses for 14 consecutive days. Subsequently, a recovery period experiment was conducted, replicating the aforementioned procedure, followed by an additional 2-week recovery period for the mice. Following 14 consecutive days of ad...
Source: Toxicology - February 18, 2024 Category: Toxicology Authors: Xiao-Ting Zhang Xu Zhang Meng-Wei Wang Chen Zhang Rui Weng Xu Xu Zu-Xi Gu Jian-Ping Gao Source Type: research
