Toxicovigilance 2.0 - modern approaches for the hazard identification and risk assessment of toxicants in human beings: A review
In conclusion, we will present the direction that modern toxicovigilance should take, incorporating available artificial intelligence methods to maximise efficiency.PMID:38367941 | DOI:10.1016/j.tox.2024.153755 (Source: Toxicology)
Source: Toxicology - February 17, 2024 Category: Toxicology Authors: Łukasz Niżnik Joanna Toporowska-Ka źmierak Karolina Jab łońska Natalia G łąb Sabina Stach Julia Florek Marta Sowi ńska Aleksandra Adamczyk Kamil Jurowski Source Type: research
The m6A reader IGF2BP1 attenuates the stability of RPL36 and cell proliferation to mediate benzene hematotoxicity by recognizing m6A modification
In conclusion, the m6A reader IGF2BP1 attenuates the stability of RPL36 and cell proliferation to mediate benzene hematotoxicity by recognizing m6A modification. IGF2BP1 and RPL36 may be key molecules and potential therapeutic targets for benzene hematotoxicity.PMID:38367942 | DOI:10.1016/j.tox.2024.153758 (Source: Toxicology)
Source: Toxicology - February 17, 2024 Category: Toxicology Authors: Jingyu Wang Xiaoli Guo Yujiao Chen Wei Zhang Jing Ren Ai Gao Source Type: research
Toxicovigilance 2.0 - modern approaches for the hazard identification and risk assessment of toxicants in human beings: A review
In conclusion, we will present the direction that modern toxicovigilance should take, incorporating available artificial intelligence methods to maximise efficiency.PMID:38367941 | DOI:10.1016/j.tox.2024.153755 (Source: Toxicology)
Source: Toxicology - February 17, 2024 Category: Toxicology Authors: Łukasz Niżnik Joanna Toporowska-Ka źmierak Karolina Jab łońska Natalia G łąb Sabina Stach Julia Florek Marta Sowi ńska Aleksandra Adamczyk Kamil Jurowski Source Type: research
The m6A reader IGF2BP1 attenuates the stability of RPL36 and cell proliferation to mediate benzene hematotoxicity by recognizing m6A modification
In conclusion, the m6A reader IGF2BP1 attenuates the stability of RPL36 and cell proliferation to mediate benzene hematotoxicity by recognizing m6A modification. IGF2BP1 and RPL36 may be key molecules and potential therapeutic targets for benzene hematotoxicity.PMID:38367942 | DOI:10.1016/j.tox.2024.153758 (Source: Toxicology)
Source: Toxicology - February 17, 2024 Category: Toxicology Authors: Jingyu Wang Xiaoli Guo Yujiao Chen Wei Zhang Jing Ren Ai Gao Source Type: research
Metformin inhibits OCTN1- and OCTN2-mediated hepatic accumulation of doxorubicin and alleviates its hepatotoxicity in mice
In conclusion, our study demonstrated that MET alleviates DOX hepatotoxicity by inhibiting OCTN1- and OCTN2-mediated DOX uptake in vitro (mouse hepatocytes and HepaRG or HepG2 cells) and in mice.PMID:38364893 | DOI:10.1016/j.tox.2024.153757 (Source: Toxicology)
Source: Toxicology - February 16, 2024 Category: Toxicology Authors: Mingyang Chen Yaodong Yi Binxin Chen Hengbin Zhang Minlei Dong Luexiang Yuan Hui Zhou Huidi Jiang Zhiyuan Ma Source Type: research
Metformin inhibits OCTN1- and OCTN2-mediated hepatic accumulation of doxorubicin and alleviates its hepatotoxicity in mice
In conclusion, our study demonstrated that MET alleviates DOX hepatotoxicity by inhibiting OCTN1- and OCTN2-mediated DOX uptake in vitro (mouse hepatocytes and HepaRG or HepG2 cells) and in mice.PMID:38364893 | DOI:10.1016/j.tox.2024.153757 (Source: Toxicology)
Source: Toxicology - February 16, 2024 Category: Toxicology Authors: Mingyang Chen Yaodong Yi Binxin Chen Hengbin Zhang Minlei Dong Luexiang Yuan Hui Zhou Huidi Jiang Zhiyuan Ma Source Type: research
Identification of toxicity-induced biomarkers in human non-immune airway cells exposed to respiratory sensitizers: a mechanistic approach
Toxicology. 2024 Feb 13:153750. doi: 10.1016/j.tox.2024.153750. Online ahead of print.ABSTRACTOccupational asthma covers a group of work-related diseases whose clinical manifestations include airway hyperresponsiveness and airflow limitation. Although the chemical respiratory allergy (CRA) induced by Low Molecular Weight (LMW) sensitizers is a major concern, especially in terms of the regulatory framework, to date there are no methods available for preclinically addressing this toxicological outcome, as its mechanistic background is not fully understood at molecular or cellular levels. This paper proposes a mechanistic stu...
Source: Toxicology - February 15, 2024 Category: Toxicology Authors: Artur Christian Garcia da Silva S érgio de Morais Carvalho Filho Izadora Caroline Furtado de Mendon ça Marize Campos Valadares Source Type: research
Identification of toxicity-induced biomarkers in human non-immune airway cells exposed to respiratory sensitizers: a mechanistic approach
Toxicology. 2024 Feb 13:153750. doi: 10.1016/j.tox.2024.153750. Online ahead of print.ABSTRACTOccupational asthma covers a group of work-related diseases whose clinical manifestations include airway hyperresponsiveness and airflow limitation. Although the chemical respiratory allergy (CRA) induced by Low Molecular Weight (LMW) sensitizers is a major concern, especially in terms of the regulatory framework, to date there are no methods available for preclinically addressing this toxicological outcome, as its mechanistic background is not fully understood at molecular or cellular levels. This paper proposes a mechanistic stu...
Source: Toxicology - February 15, 2024 Category: Toxicology Authors: Artur Christian Garcia da Silva S érgio de Morais Carvalho Filho Izadora Caroline Furtado de Mendon ça Marize Campos Valadares Source Type: research
Could the gut microbiota be capable of making individuals more or less susceptible to environmental toxicants?
This study is the first to highlight the overlap between some of the bacteria found to be altered by metal exposure and the bacteria that also aid the host organism in the metabolism of these metals. This could be a key factor to determine the beneficial species able to minimize the toxicity of metals in future therapeutic approaches.PMID:38354972 | DOI:10.1016/j.tox.2024.153751 (Source: Toxicology)
Source: Toxicology - February 14, 2024 Category: Toxicology Authors: Marcella S A Santiago Maria Christina W Avellar Juliana E Perobelli Source Type: research
A novel three-dimensional Nrf2 reporter epidermis model for skin sensitization assessment
Toxicology. 2024 Feb 8:153743. doi: 10.1016/j.tox.2024.153743. Online ahead of print.ABSTRACTSkin sensitization assessment has progressed from the use of animal models towards the application of New Approach Methodologies (NAMs). Several skin sensitization NAMs are accepted for regulatory use, but a majority relies on submerged in vitro cell cultures that limit their applicability domain, posing challenges for testing hydrophobic chemicals and mixtures. A newly developed three-dimensional (3D) Nrf2 reporter epidermis model for skin sensitization assessment is reported. This NAM may help to overcome these limitations. The N...
Source: Toxicology - February 10, 2024 Category: Toxicology Authors: K Brandmair D Dising D Finkelmeie A Schepky J Kuehnl J Ebmeyea A Burger-Kentischer Source Type: research
miR-15b-5p promotes HgCl < sub > 2 < /sub > -induced chicken embryo kidney cells ferroptosis by targeting β-TrCP-mediated ATF4 ubiquitin degradation
In conclusion, our study highlighted the crucial role of the miR-15b-5p/β-TrCP/ATF4 axis in HgCl2-induced nephrotoxicity, offering a new therapeutic target for understanding the mechanism of HgCl2 nephrotoxicity.PMID:38325558 | DOI:10.1016/j.tox.2024.153742 (Source: Toxicology)
Source: Toxicology - February 7, 2024 Category: Toxicology Authors: Hong-Yu Fu Yue Li Han Cui Jiu-Zhi Li Wan-Xue Xu Xi Wang Rui-Feng Fan Source Type: research
Notoginsenoside R1 attenuates bupivacaine induced neurotoxicity by activating Jak1/Stat3/Mcl1 pathway
In this study, we explored the function and mechanism of NG-R1 in alleviating bupivacaine-induced neurotoxicity in mouse hippocampal neuronal (HT-22) and mouse neuroblastoma (Neuro-2a) cell lines. Our results exhibited that NG-R1 treatment can significantly rescue the decline of cell survival induced by bupivacaine. Tunel staining and western blotting showed that NG-R1 could attenuate BPV‑induced cell apoptosis. Besides, we focused on Mcl1 as a potential target as it showed opposite expression tendency in response to NG-R1 and bupivacaine exposure. Mcl1 knockdown blocked the inhibitory effect of NG-R1 on cell apoptosis a...
Source: Toxicology - February 5, 2024 Category: Toxicology Authors: Yu Yang Jiwen Wu Shicheng Feng Hao Yu Chuanxin Liu Shuai Wang Source Type: research
Restoration of nerve agent impaired neuromuscular transmission in rat diaphragm by bispyridinium non-oximes - Structure-activity relationships
Toxicology. 2024 Feb 3;503:153741. doi: 10.1016/j.tox.2024.153741. Online ahead of print.ABSTRACTOrganophosphate (OP) poisoning is currently treated with atropine, oximes and benzodiazepines. The nicotinic signs, i.e., respiratory impairment, can only be targeted indirectly via the use of oximes as reactivators of OP-inhibited acetylcholinesterase. Hence, compounds selectively targeting nicotinic acetylcholine receptors (nAChRs) might fundamentally improve current treatment options. The bispyridinium compound MB327 has previously shown some therapeutic effect against nerve agents in vitro and in vivo. Nevertheless, compoun...
Source: Toxicology - February 4, 2024 Category: Toxicology Authors: Niko Amend Christopher M Timperley Mike Bird A Christopher Green Franz Worek Thomas Seeger Source Type: research
Differential eigengene network analysis reveals benzo[a]pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin consensus regulatory network in human liver cell line HepG2
In this study, we used transcriptomics data from the BaP- and TCCD-exposed human liver cell line HepG2, and performed differential eigengene network analysis to understand the correlation among genes and to untangle the common regulatory mechanism in the action of BaP and TCDD. The genes were grouped into 11 meta-modules with an overall preservation of 0.72 and were also segregated into three consensus time clusters: 12, 24, and 48 h. The analysis showed that the consensus genes in each time cluster were either directly regulated by the AHR or the AHR-TF interactions. Some TFs form a direct physical interaction with AHR su...
Source: Toxicology - February 4, 2024 Category: Toxicology Authors: Bojana Stanic Nata ša Sukur Nemanja Milo šević Jelena Markovic Filipovic Kristina Pogrmic-Majkic Nebojsa Andric Source Type: research
Development of a hierarchical support vector regression-based in silico model for the prediction of the cysteine depletion in DPRA
In this study, a quantitative structure-activity relationship (QSAR) model was developed using the innovative hierarchical support vector regression (HSVR) scheme. The aim was to quantitatively predict the potential for skin sensitization by analyzing the percent of cysteine depletion in Direct Peptide Reactivity Assay (DPRA). The results demonstrated accurate, consistent, and robust predictions in the training set, test set, and outlier set. Consequently, this model can be employed to estimate skin sensitization potential of novel or virtual compounds.PMID:38307191 | DOI:10.1016/j.tox.2024.153739 (Source: Toxicology)
Source: Toxicology - February 2, 2024 Category: Toxicology Authors: Giang H Ta Ching-Feng Weng Max K Leong Source Type: research
