miR-15b-5p promotes HgCl < sub > 2 < /sub > -induced chicken embryo kidney cells ferroptosis by targeting β-TrCP-mediated ATF4 ubiquitin degradation

In conclusion, our study highlighted the crucial role of the miR-15b-5p/β-TrCP/ATF4 axis in HgCl2-induced nephrotoxicity, offering a new therapeutic target for understanding the mechanism of HgCl2 nephrotoxicity.PMID:38325558 | DOI:10.1016/j.tox.2024.153742

Source: Toxicology - February 7, 2024 Category: Toxicology Authors: Hong-Yu Fu Yue Li Han Cui Jiu-Zhi Li Wan-Xue Xu Xi Wang Rui-Feng Fan Source Type: research