Unexpected results with light-gated chloride channel GtACR2 lead to improved technique
(Baylor College of Medicine) Characterization of light-gated chloride channel GtACR2 in mouse cortical neurons revealed that GtACR2 activation inhibited the soma, but unexpectedly depolarized the presynaptic terminals resulting in neurotransmitter release. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 13, 2018 Category: Biology Source Type: news

Sodium Chloride Injection USP, 0.9% Vials and Syringes (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - August 8, 2018 Category: Drugs & Pharmacology Source Type: news

FDA Approves Generic Potassium Chloride Under New Pathway
(MedPage Today) -- Goal is to increase competition, cut prices (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - August 8, 2018 Category: American Health Source Type: news

Sodium Chloride Injection USP, 0.9% Vials (New - Currently in Shortage
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - August 2, 2018 Category: Drugs & Pharmacology Source Type: news

Potassium Chloride Injection (New - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - August 1, 2018 Category: Drugs & Pharmacology Source Type: news

Influence of Hemostatic Agents in the Prognosis of Periapical Surgery: A Randomized Study of Epinephrine versus Aluminum Chloride
ConclusionsThe present study found no association between the use of epinephrine or aluminum chloride as hemostatic agents on the prognosis of periapical surgery. The efficacy of hemostatic agents at the time of surgery showed no relationship with the healing outcome. (Source: Dental Technology Blog)
Source: Dental Technology Blog - August 1, 2018 Category: Dentistry Source Type: news

Infugem (Gemcitabine in Sodium Chloride injection) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 25, 2018 Category: Drugs & Pharmacology Source Type: news

Sodium Chloride 0.9% Injection Bags (Updated - Currently in Shortage)e)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - July 23, 2018 Category: Drugs & Pharmacology Source Type: news

Sodium Chloride Injection USP, 0.9% Vials (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - July 20, 2018 Category: Drugs & Pharmacology Source Type: news

Judge Officially Closes Vinyl Chloride Case Related To Paulsboro Train Derailment
TRENTON, N.J. - The federal judge presiding over the lawsuit brought by New Jersey residents who contended that they were exposed to vinyl chloride as a result of a train derailment officially terminated the case on July 2 nearly one year after a panel of the Third Circuit U.S. Court of Appeals issued a mandate that the case lacked federal jurisdiction (In re: Paulsboro Derailment Cases, No. 13-784, D. N.J.). (Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News)
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - July 20, 2018 Category: Medical Law Source Type: news

Electrofluorochromism at the single-molecule level
The interplay between the oxidation state and the optical properties of molecules is important for applications in displays, sensors, and molecular-based memories. The fundamental mechanisms occurring at the level of a single molecule have been difficult to probe. We used a scanning tunneling microscope (STM) to characterize and control the fluorescence of a single zinc-phthalocyanine radical cation adsorbed on a sodium chloride–covered gold (111) sample. The neutral and oxidized states of the molecule were identified on the basis of their fluorescence spectra, which revealed very different emission energies and vibr...
Source: ScienceNOW - July 19, 2018 Category: Science Authors: Doppagne, B., Chong, M. C., Bulou, H., Boeglin, A., Scheurer, F., Schull, G. Tags: Physics reports Source Type: news

Sun Pharma gets USFDA nod for cancer treatment injection
The approval from the USFDA is for INFUGEM injection (gemcitabine in 0.9 per cent sodium chloride injection) 10 mg/mL, for intravenous use in a ready-to-administer bag, it added. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - July 18, 2018 Category: Pharmaceuticals Source Type: news

Walrus and Avrio ’s Slow-Mag ® Welcome You to Your 40 ’s– Where...
Relatable Campaign Highlights the Benefits of Magnesium Chloride Plus Calcium on Aging Muscles(PRWeb July 11, 2018)Read the full story at https://www.prweb.com/releases/2018/07/prweb15618211.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - July 11, 2018 Category: Pharmaceuticals Source Type: news

Medical News Today: What is the normal chloride level?
The chloride levels in the blood should be 96 and 106 milliequivalents per liter (MEq/L). High levels indicate hyperchloremia, while low levels indicate hypochloremia. These conditions can have many causes including severe dehydration. Treatment depends on the individual cause but may involve rehydrating. Learn more. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 29, 2018 Category: Consumer Health News Tags: Blood / Hematology Source Type: news

Sodium Chloride Injection USP, 0.9% Vials (New - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - June 21, 2018 Category: Drugs & Pharmacology Source Type: news

3 big retailers phasing out paint strippers with chemical linked to deaths
Health authorities believe strippers with methylene chloride have claimed dozens of lives (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - June 21, 2018 Category: Consumer Health News Source Type: news

Three major retailers phasing out paint strippers with methylene chloride
After a CBS News investigation?, three major retailers – Home Depot, Sherwin-Williams and Lowe's – now plan to phase out paint-stripping products containing a potentially deadly chemical, methylene chloride. Anna Werner reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - June 21, 2018 Category: Consumer Health News Source Type: news

Infusion Type Doesn't Affect Brain Outcomes in Pediatric DKA Infusion Type Doesn't Affect Brain Outcomes in Pediatric DKA
Neither fluid infusion rate nor sodium chloride concentration appeared to influence neurologic outcomes in children with diabetic ketoacidosis.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 13, 2018 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

IV Fluid Specs Do Not Influence Neuro Outcomes in Kids w/DKA
WEDNESDAY, June 13, 2018 -- Neurologic outcomes in children with diabetic ketoacidosis are similar regardless of the rate of administration or the sodium chloride content of intravenous fluids, according to a study published in the June 14 issue of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 13, 2018 Category: Pharmaceuticals Source Type: news

Manganese (Manganese Chloride Injection Solution) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 7, 2018 Category: Drugs & Pharmacology Source Type: news

EPA Releases New Rules for TSCA Asbestos Review
As part of the latest updates to the reformed Toxic Substances Control Act (TSCA), the U.S. Environmental Protection Agency (EPA) last week proposed new rules for the risk evaluation of asbestos. The EPA released a significant new use rule (SNUR) proposal which would allow the agency to prevent new uses of asbestos, the naturally occurring mineral linked to deadly cancers such as mesothelioma. It is the first time the EPA has issued such an action. The SNUR would require the agency’s approval before asbestos-containing goods can be manufactured, imported or processed. It would grant the EPA power to evaluate the inte...
Source: Asbestos and Mesothelioma News - June 5, 2018 Category: Environmental Health Authors: Daniel King Source Type: news

Can cannabinoid hyperemesis syndrome be fatal?
shutterstock.com/Stanimir G. Stoev 2.5 out of 5 stars Cannabinoid Hyperemesis Syndrome: Reports of Fatal Cases. Nourbakhsh M et al. J Forensic Sci 2018 May 15 [Epub ahead of print] Abstract This paper reports on 2 fatal cases that the authors argue were attributable to the effects of cannabinoid hyperemesis syndrome (CHS). CASE #1: A 27-year-old woman is brought to hospital by ambulance after friend found her unresponsive with agonal respirations. On arrival she was apneic with bradycardia and decorticate posturing. Pupils were fixed and dilated. Serum glucose was 34 mg/dL. After presentation she deteriorate...
Source: The Poison Review - May 30, 2018 Category: Toxicology Authors: Leon Gussow Tags: Medical cannabinoid hyperemesis syndrome cannabis cyclic vomiting fatality marijuana Source Type: news

Lowe ’s Says It Will Ditch Dangerous Solvents
The company’s statement comes just weeks after the EPA announced it would finalize a proposed ban on methylene chloride for consumer uses. (Source: WebMD Health)
Source: WebMD Health - May 29, 2018 Category: Consumer Health News Source Type: news

Chemical compound produces beneficial inflammation, remyelination that could help treat MS
(University of California - Riverside) Researchers at the University of California, Riverside, report that indazole chloride, a synthetic compound that acts on one form of the body's estrogen receptors, is able to remyelinate (add new myelin to) damaged axons and alter the body's immune system -- findings that could help treat multiple sclerosis. Drugs available to treat MS alter the immune system but do not induce repair of damaged axons. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 29, 2018 Category: International Medicine & Public Health Source Type: news

Cobalt-catalyzed asymmetric hydrogenation of enamides enabled by single-electron reduction
Identifying catalyst activation modes that exploit one-electron chemistry and overcome associated deactivation pathways will be transformative for developing first-row transition metal catalysts with performance equal or, ideally, superior to precious metals. Here we describe a zinc-activation method compatible with high-throughput reaction discovery that identified scores of cobalt-phosphine combinations for the asymmetric hydrogenation of functionalized alkenes. An optimized catalyst prepared from (R,R)-Ph-BPE {Ph-BPE, 1,2-bis[(2R,5R)-2,5-diphenylphospholano]ethane} and cobalt chloride [CoCl2·6H2O] exhibited high ...
Source: ScienceNOW - May 24, 2018 Category: Science Authors: Friedfeld, M. R., Zhong, H., Ruck, R. T., Shevlin, M., Chirik, P. J. Tags: Chemistry reports Source Type: news

Combining postmortem vitreous sodium and chloride and lung-body ratio in aiding the diagnosing saltwater drowning - Tse R, Garland J, Kesha K, Morrow P, Lam L, Elstub H, Cala A, Spark A, Palmiere C, Stables S.
Diagnosing death due to drowning can be difficult, and several postmortem findings have been postulated to aid the diagnosis. Increased lung weights are often seen in drowning deaths. Lung-body (LB) ratio was described to be the best anatomical lung measur... (Source: SafetyLit)
Source: SafetyLit - May 21, 2018 Category: International Medicine & Public Health Tags: Drowning, Suffocation Source Type: news

Cellular valve structure opens up potential novel therapies
(University of Zurich) Biochemists at the University of Zurich have determined the detailed structure of a volume-regulated chloride channel. This cellular valve is activated in response to swelling to prevent the cell from bursting. The protein also plays an important role in the uptake of chemotherapeutics and the release of neurotransmitters after a stroke. The controlled regulation of its activity thus opens up a promising strategy for novel therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 16, 2018 Category: Cancer & Oncology Source Type: news

Once again, EPA considers ban on deadly paint stripper chemical
EPA is once again considering a ban of a potentially deadly chemical found in paint strippers. Earlier this year, the Trump administration was backing away from banning methylene chloride. The Obama administration first proposed the ban. Anna Werner reports on how pressure from families who lost loved ones helped influence the agency. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - May 11, 2018 Category: Consumer Health News Source Type: news

K-LOR (Potassium Chloride) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 9, 2018 Category: Drugs & Pharmacology Source Type: news

Sodium Chloride 0.9% Injection Bags (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - May 8, 2018 Category: Drugs & Pharmacology Source Type: news

What Causes Hyponatremia?
Discussion Normal kidneys regulate water balance to maintain a plasma osmolality of 275-290 mOsm/kg normally. Thirst and arginine vasopressin or antidiuretic hormone (ADH) are the primary regulators of plasma osmolality. ADH is made in the hypothalamus and released by the posterior pituitary gland. ADH acts on the kidney’s distal collecting duct to increase water reabsorption. ADH is appropriately released in hypovolemic states, such as dehydration caused by gastroenteritis. ADH has an ~10 minute half-life and therefore can respond to rapid changes in volume status. Sodium balance is regulated by aldosterone (as part...
Source: PediatricEducation.org - April 23, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Potassium Chloride Injection (Updated - Discontinuation)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - April 19, 2018 Category: Drugs & Pharmacology Source Type: news

Stores Urged to Pull Products With Deadly Chemical Stores Urged to Pull Products With Deadly Chemical
Environmental groups have called on retailers to stop selling products containing methylene chloride, a chemical sold in most hardware stores that has claimed at least three lives in the last year.WebMD Health News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 6, 2018 Category: Consumer Health News Tags: Emergency Medicine News Source Type: news

Mivacron (Mivacurium Chloride Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 5, 2018 Category: Drugs & Pharmacology Source Type: news

Company Seeks Sanctions Against Couple, Counsel In Chemical Exposure Case
LANCASTER, Pa. - The chemical company sued by a Pennsylvania couple who contend that the husband developed cancer as a result of being exposed to trichloroethylene (TCE) and methylene chloride (MC) in his workplace on March 15 filed a brief in state court arguing that the state court should sustain the company's objections to the couple's third amended complaint and impose sanctions on the couple and their counsel (Paul Rogers, et al. v. Brenntag Northeast Inc., et al., No. 16-05583, Pa. Comm. Pls., Lancaster Co.). (Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News)
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - April 3, 2018 Category: Medical Law Source Type: news

Why is common paint stripper chemical linked to deaths still on shelves?
Environmental Protection Agency says methylene chloride poses an unreasonable risk ​ but a proposed ban was postponed (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - April 1, 2018 Category: Consumer Health News Source Type: news

The Toxic Impact of Hurricane Harvey
HOUSTON (AP) — A toxic onslaught from the nation's petrochemical hub was largely overshadowed by the record-shattering deluge of Hurricane Harvey as residents and first responders struggled to save lives and property. More than a half-year after floodwaters swamped America's fourth-largest city, the extent of this environmental assault is beginning to surface, while questions about the long-term consequences for human health remain unanswered. County, state and federal records pieced together by The Associated Press and The Houston Chronicle reveal a far more widespread toxic impact than authorities publicly reported...
Source: JEMS: Journal of Emergency Medical Services News - March 22, 2018 Category: Emergency Medicine Authors: Frank Bajak, Associated Press & Lise Olsen, Houston Chronicle Tags: Major Incidents News Source Type: news

Phosphoric acid as a precursor to chemicals traditionally synthesized from white phosphorus
White phosphorus, generated in the legacy thermal process for phosphate rock upgrading, has long been the key industrial intermediate for the synthesis of phosphorus-containing chemicals, including herbicides, flame-retardants, catalyst ligands, battery electrolytes, pharmaceuticals, and detergents. In contrast, phosphate fertilizers are made on a much larger scale from phosphoric acid, obtained by treating phosphate rock with sulfuric acid. Dehydration of phosphoric acid using sodium chloride gives trimetaphosphate, and here we report that trichlorosilane, primarily used for the production of high-purity silicon, reduces ...
Source: ScienceNOW - March 22, 2018 Category: Science Authors: Geeson, M. B., Cummins, C. C. Tags: Chemistry reports Source Type: news

Pennsylvania Couple: Company Liable For Cancer From Workplace Chemical Exposure
LANCASTER, Pa. - A Pennsylvania couple filed a brief in state court on March 4 contending that their complaint against a chemical company asserts material facts that the husband was exposed to trichloroethylene (TCE) and methylene chloride (MC), which caused him to develop a form of cancer known as multiple myeloma (Paul Rogers, et al. v. Brenntag Northeast Inc., et al., No. 16-05583, Pa. Comm. Pls., Lancaster Co.). (Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News)
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - March 20, 2018 Category: Medical Law Source Type: news

Q Biomed Inc. Announces FDA Filing for Approval of a New Manufacturing Facility for Non-Opioid Strontium Chloride SR89 Injection USP for Relief of Cancer Bone Pain
NEW YORK, March 16, 2018 -- (Healthcare Sales & Marketing Network) -- Q BioMed Inc. (OTCQB: QBIO), a commercial stage biotechnology acceleration development company, and Bio-Nucleonics, licensor of Strontium 89 Chloride, announce submission of a regulator... Biopharmaceuticals, Oncology, FDA Q Biomed, Strontium 89 Chloride, Bone Pain (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - March 16, 2018 Category: Pharmaceuticals Source Type: news

Three Reasons Not to Use Normal Saline or Crystalloids in Trauma
You're responding to a gunshot wound. When you arrive, you find a young man has been shot in the chest, and has significant hemorrhage. As you load him into the ambulance, your partner tells you he is spiking a 1-liter bag of 0.9% sodium chloride, also known as normal saline (NS).  You're curious, because the patient is hemorrhaging blood, not salt water, and ask why you’re not prepping blood products instead. Your partner responds, “Because it’s something we can give him now, and it helps with circulation.” But, does it actually help? This review provides historical information and research wi...
Source: JEMS Patient Care - March 14, 2018 Category: Emergency Medicine Authors: Brandon M. Carius, MPAS, PA-C Tags: Trauma Patient Care Source Type: news

Photocatalytic heterostructures unleash the potential of doped silver halides
Silver-doped silver chloride nanocubes affixed to silica nanospheres show enhanced photocatalytic activity and stability - a breakthrough for solar energy developments. (Source: Nanotechweb.org News)
Source: Nanotechweb.org News - February 27, 2018 Category: Nanotechnology Source Type: news

Elevated postmortem vitreous sodium and chloride level in a salt water drowning death during self-contained underwater breathing apparatus diving with diving mask in place: case report - Tse R, Garland J, Kesha K, Morrow P, Elstub H, Cala A, Spark A, Stables S, Sage M.
Elevation of postmortem vitreous sodium and chloride (PMVSC) levels in salt water drowning (SWD) is hypothesized to result from electrolyte changes in blood from salt water inhalation/ingestion during drowning. After approximately 1 hour after death, elect... (Source: SafetyLit)
Source: SafetyLit - February 26, 2018 Category: International Medicine & Public Health Tags: Drowning, Suffocation Source Type: news

Hespan (6% Hetastarch in 0 .9% Sodium Chloride Injection) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 26, 2018 Category: Drugs & Pharmacology Source Type: news

Plegisol (Potassium Chloride, Sodium Chloride, Calcium Chloride, and Magnesium Chloride Injection Solution) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 23, 2018 Category: Drugs & Pharmacology Source Type: news

Copper (Cupric Chloride Injection) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 23, 2018 Category: Drugs & Pharmacology Source Type: news

Scientists examine link between surface-water salinity, climate change
(Syracuse University) A Syracuse University researcher explores the impact of de-icing salt from roads and highways on a local watershed. She says their findings make her 'cautiously optimistic' about the watershed's future surface-water chloride concentrations. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - February 23, 2018 Category: Biology Source Type: news

Chemical Injury Case Barred By Workers' Compensation Law, Companies Say
LANCASTER, Pa. - Armstrong World Industries Inc. and a German chemical company on Feb. 8 filed a joint brief in Pennsylvania state court contending that the third amended complaint filed by a former employee who says he was injured from exposure to trichloroethylene (TCE) and methylene chloride (MC) should be dismissed because the claims are barred by the Pennsylvania Workers Compensation Act (WCA) (Jose Rivera v. Armstrong World Industries Inc., et al., No. CI-15-06542, Pa. Comm. Pls., Lancaster Co.). (Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News)
Source: LexisNexis® Mealey's™ Emerging Toxic Torts Legal News - February 21, 2018 Category: Medical Law Source Type: news