Rapid molecular evolution of pain insensitivity in multiple African rodents
Noxious substances, called algogens, cause pain and are used as defensive weapons by plants and stinging insects. We identified four previously unknown instances of algogen-insensitivity by screening eight African rodent species related to the naked mole-rat with the painful substances capsaicin, acid (hydrogen chloride, pH 3.5), and allyl isothiocyanate (AITC). Using RNA sequencing, we traced the emergence of sequence variants in transduction channels, like transient receptor potential channel TRPA1 and voltage-gated sodium channel Nav1.7, that accompany algogen insensitivity. In addition, the AITC-insensitive highveld mo...
Source: ScienceNOW - May 29, 2019 Category: Science Authors: Eigenbrod, O., Debus, K. Y., Reznick, J., Bennett, N. C., Sanchez-Carranza, O., Omerbasic, D., Hart, D. W., Barker, A. J., Zhong, W., Lutermann, H., Katandukila, J. V., Mgode, G., Park, T. J., Lewin, G. R. Tags: Evolution, Neuroscience r-articles Source Type: news

SCA Pharmaceuticals LLC. Issues Voluntary Nationwide Recall of Furosemide 100 mg in 0.9% Sodium Chloride due to Presence of Precipitate
, SCA Pharmaceuticals LLC ( “SCA Pharma”) is voluntarily recalling 7 lots of the injectable product Furosemide 100 mg in 0.9% Sodium Chloride 100 mg bag to the consumer level. This product is being recalled for visible particulate matter believed to be furosemide precipitate. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - May 24, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Calcium Chloride Injection 10% (Calcium Chloride) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 21, 2019 Category: Drugs & Pharmacology Source Type: news

Chloride-channel in muscle cells provides new insights for muscle diseases
(University of Copenhagen The Faculty of Health and Medical Sciences) Researchers from the University of Copenhagen have mapped the structure of an important channel in human muscle cells. The new insights about the chloride-channel can contribute to greater understanding of muscle diseases such as ALS, and the findings may enhance drug development at NMD Pharma. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - April 30, 2019 Category: International Medicine & Public Health Source Type: news

Sodium Chloride 0.9% Injection Bags (Updated - Currently in Shortage)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - April 25, 2019 Category: Drugs & Pharmacology Source Type: news

PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel
Severe local acidosis causes tissue damage and pain, and is one of the hallmarks of many diseases including ischemia, cancer, and inflammation. However, the molecular mechanisms of the cellular response to acid are not fully understood. We performed an unbiased RNA interference screen and identified PAC (TMEM206) as being essential for the widely observed proton-activated Cl– (PAC) currents (ICl,H). Overexpression of human PAC in PAC knockout cells generated ICl,H with the same characteristics as the endogenous ones. Zebrafish PAC encodes a PAC channel with distinct properties. Knockout of mouse Pac abolished ICl,H i...
Source: ScienceNOW - April 24, 2019 Category: Science Authors: Yang, J., Chen, J., del Carmen Vitery, M., Osei-Owusu, J., Chu, J., Yu, H., Sun, S., Qiu, Z. Tags: Cell Biology reports Source Type: news

The Most Common Active Ingredient In Hand Sanitizer Is Still Under FDA Investigation
(CNN) — After reviewing the safety and effectiveness of hand sanitizers, the US Food and Drug Administration has ruled that dozens of active ingredients can’t be used in the antiseptic rubs, but the agency still wants answers about the most common active ingredient. The rule, issued Thursday, “reaffirmed our need for more data on three other active ingredients, including ethyl alcohol, which is the most commonly used ingredient in hand sanitizers, to help the agency ensure that these products are safe and effective for regular use by consumers,” Dr. Janet Woodcock, director of the agency’s Cen...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - April 12, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN hand sanitzer Source Type: news

Scientists find a way to make crisps taste salty with less of the salt that causes obesity
Carolyn Ross, a food science professor at Washington State University, created the salt mix, which contains less sodium chloride, with a team of colleagues. (Source: the Mail online | Health)
Source: the Mail online | Health - April 12, 2019 Category: Consumer Health News Source Type: news

Keeping the taste, reducing the salt
(Washington State University) Washington State University researchers have found a way to make food taste salty but with less of the sodium chloride tied to poor health. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 11, 2019 Category: Biology Source Type: news

Spin coating epitaxial films
Spin-coated films, such as photoresists for lithography or perovskite films for solar cells, are either amorphous or polycrystalline. We show that epitaxial films of inorganic materials such as cesium lead bromide (CsPbBr3), lead(II) iodide (PbI2), zinc oxide (ZnO), and sodium chloride (NaCl) can be deposited onto a variety of single-crystal and single-crystal–like substrates by simply spin coating either solutions of the material or precursors to the material. The out-of-plane and in-plane orientations of the spin-coated films are determined by the substrate. The thin stagnant layer of supersaturated solution produc...
Source: ScienceNOW - April 10, 2019 Category: Science Authors: Kelso, M. V., Mahenderkar, N. K., Chen, Q., Tubbesing, J. Z., Switzer, J. A. Tags: Chemistry, Materials Science reports Source Type: news

Researchers uncover hidden deicer risks affecting bridge health
(Washington State University) Common magnesium chloride deicers used on roadways and bridges around the U.S. may be doing more damage than previously thought, researchers have found. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 4, 2019 Category: Biology Source Type: news

Strides arm and its partner get USFDA nod for hypokalemia treatment drug
The approved product, used in treatment of patients with hypokalemia, is a generic version of Merck, Inc's Potassium Chloride extended-release tablets, a regulatory filing said. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 1, 2019 Category: Pharmaceuticals Source Type: news