What Types of New Therapies are Available for Cystic Fibrosis?
Discussion
Cystic fibrosis (CF) was identified in 1938 by Dr. Dorothy Andersen who described 49 patients with pancreatic insufficiency. Since that time significant achievements in the knowledge about the disease and treatments for patients have changed the mortality from a few months to patients living into middle adulthood or even later. Quality of life for patients and their families and friends has also markedly improved.
CF is the classic Mendelian autosomal recessive genetic disorder which is a worldwide disorder but affects people of north European ancestry more often where the main mutation is more common. There are...
Source: PediatricEducation.org - June 28, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news
Inhaling muscle spray: a rising trend of abuse - Pothiawala S, Yong CK, Charles R.
Ethyl chloride was popular as an inhalant recreational drug in the 1980s. It is easily available in pharmacies as well as sold online as a topical anesthetic spray for pain relief. In recent times, its use is gaining popularity again among the youth as an ... (Source: SafetyLit)
Source: SafetyLit - June 1, 2021 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Researchers discover how cells can survive in high salt concentrations
(Institute for Research in Biomedicine (IRB Barcelona)) Researchers from IRB Barcelona and UPF have identified a chloride channel involved in cell volume recovery under osmotic stress.The results have been published in the journal PNAS. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 1, 2021 Category: Biology Source Type: news
KCL in NS (Potassium Chloride in Sodium Chloride Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 21, 2021 Category: Drugs & Pharmacology Source Type: news
Side-by-side field comparison of snow and ice control chemicals for anti-icing applications - Rainwater KA, Lawson WD, Surles JG, Estrada FJ, Jackson WA.
This paper presents findings from a side-by-side field comparison of the effectiveness of sodium chloride-based road salt brine (RSB) and magnesium chloride-based Meltdown Apex ™ liquid (MDA) as anti-icing chemicals for snow and ice control associated wit... (Source: SafetyLit)
Source: SafetyLit - May 17, 2021 Category: International Medicine & Public Health Tags: Environmental Issues, Climate, Geophysics Source Type: news
Assessment of methylene chloride-related fatalities in the United States, 1980-2018 - Hoang A, Fagan K, Cannon DL, Rayasam SDG, Harrison R, Shusterman D, Singla V.
IMPORTANCE: Methylene chloride is a halogenated organic solvent widely used in paint strippers, cleaners, adhesives, and sealants. Despite label warnings and occupational standards, methylene chloride-related fatalities continue to occur in the United Stat... (Source: SafetyLit)
Source: SafetyLit - April 22, 2021 Category: International Medicine & Public Health Tags: Home and Consumer Product Safety Source Type: news
Methylene Chloride-Related Fatalities Persist in US Methylene Chloride-Related Fatalities Persist in US
Occupational safety standards and warning labels on methylene chloride haven ' t entirely eliminated fatalities from exposure to this widely used halogenated organic solvent, a new study suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 21, 2021 Category: Consumer Health News Tags: Internal Medicine News Source Type: news
Workers' Deaths From Paint Stripping Chemicals Are on the Rise
WEDNESDAY, April 21, 2021 -- A deadly chemical in paint strippers continues to kill workers despite its known dangers, a new study finds.
The chemical methylene chloride, also known as dichloromethane (DCM), is a solvent found in paint strippers,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 21, 2021 Category: General Medicine Source Type: news
CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function
Chloride intracellular channels 1 (CLIC1) and 4 (CLIC4) are expressed in endothelial cells and regulate angiogenic behaviors in vitro, and the expression of Clic4 is important for vascular development and function in mice. Here, we found that CLIC1 and CLIC4 in endothelial cells regulate critical G protein–coupled receptor (GPCR) pathways associated with vascular development and disease. In cultured endothelial cells, we found that CLIC1 and CLIC4 transiently translocated to the plasma membrane in response to sphingosine 1-phosphate (S1P). Both CLIC1 and CLIC4 were essential for mediating S1P-induced activation of th...
Source: Signal Transduction Knowledge Environment - April 20, 2021 Category: Science Authors: Mao, D. Y., Kleinjan, M. L., Jilishitz, I., Swaminathan, B., Obinata, H., Komarova, Y. A., Bayless, K. J., Hla, T., Kitajewski, J. K. Tags: STKE Research Articles Source Type: news
Deaths rising in workers using methylene chloride paint strippers
(University of California - San Francisco) Researchers and physicians from the Occupational Safety and Health Administration (OSHA) and UC San Francisco have found that deaths of workers using methylene chloride paint strippers are on the rise. The solvent is widely used in paint strippers, cleaners, adhesives and sealants. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 19, 2021 Category: Cancer & Oncology Source Type: news
Evaluating the Antimicrobial Properties of Commercial Hand Sanitizers, MSphere
Hand sanitizers have been developed as a convenient means to decontaminate an individual ' s hands of bacterial pathogens in situations in which soap and water are not available. Yet to our knowledge, no study has compared the antibacterial efficacy of a large collection of hand sanitizers. Using zone of growth inhibition and kill curve assays, we assessed the performance of 46 commercially available hand sanitizers that were obtained from national chain big-box stores, gasoline stations, pharmacies, and boutiques for antibacterial activity toward prototypical Gram-positive ( Staphylococcus aureus ) and Gram-negative ( Esc...
Source: Current Awareness Service for Health (CASH) - April 15, 2021 Category: Consumer Health News Source Type: news
Potassium Chloride Extended Release Tablets (Potassium Chloride Extended Release Tablets) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 14, 2021 Category: Drugs & Pharmacology Source Type: news
< a href= " /news-events/nih-research-matters/sweat-sticker-diagnosing-cystic-fibrosis " > “Sweat sticker” for diagnosing cystic fibrosis < /a >
Researchers created a “sweat sticker” for measuring chloride concentrations in sweat, a sign of cystic fibrosis. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - April 13, 2021 Category: Consumer Health News Source Type: news
Gate-controlled BCS-BEC crossover in a two-dimensional superconductor
We report crossover behavior from the BCS limit to the BEC limit realized by varying carrier density in a two-dimensional superconductor, electron-doped zirconium nitride chloride. The phase diagram, established by simultaneous measurements of resistivity and tunneling spectra under ionic gating, demonstrates a pseudogap phase in the low-doping regime. The ratio of the superconducting transition temperature and Fermi temperature in the low–carrier density limit is consistent with the theoretical upper bound expected in the BCS-BEC crossover regime. These results indicate that the gate-doped semiconductor provide...
Source: ScienceNOW - April 8, 2021 Category: Science Authors: Nakagawa, Y., Kasahara, Y., Nomoto, T., Arita, R., Nojima, T., Iwasa, Y. Tags: Materials Science, Physics reports Source Type: news
Methylene chloride burns: a case report and review of literature - Chauhan N, Prasad RS.
Chemical burns account for a small percentage of burns but contribute to significant number of burn-related mortalities. The major challenge posed by chemical burns is difficulty in correct depth estimation, as the damage continues to progress until they a... (Source: SafetyLit)
Source: SafetyLit - April 7, 2021 Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news
