Fluorescence and dielectric spectroscopy identification of polyvinyl chloride/NiO nanocomposites
Publication date: Available online 4 April 2020Source: Journal of Molecular StructureAuthor(s): T.A. Taha, N. Hendawy, S. El-Rabaie, Asmaa Esmat, M.K. El-Mansy (Source: Journal of Molecular Structure)
Source: Journal of Molecular Structure - April 4, 2020 Category: Molecular Biology Source Type: research

Clinical utility and value contribution of an MRI-positive line marker for image-guided brachytherapy in gynecologic malignancies
The purpose of this study was to investigate the utility of a novel MRI-positive line marker, composed of C4:S (cobalt chloride –based contrast agent) encapsulated in high-density polyethylene tubing, in permitting dosimetry and treatment planning directly on MRI. (Source: Brachytherapy)
Source: Brachytherapy - April 4, 2020 Category: Cancer & Oncology Authors: Matthew S. Ning, Sastry Vedam, Jingfei Ma, R. Jason Stafford, Teresa L. Bruno, Mandy Cunningham, Christine Starks, Ann Lawyer, Aradhana M. Venkatesan, Li Wang, Jihong Wang, Nicholas D. Olivieri, Alexis B. Guzman, James R. Incalcaterra, Nikhil G. Thaker, M Source Type: research

Properties of different types of dry electrodes for wearable smart monitoring devices.
Authors: Popović-Maneski L, Ivanović MD, Atanasoski V, Miletić M, Zdolšek S, Bojović B, Hadžievski L Abstract Wearable smart monitors (WSMs) applied for the estimation of electrophysiological signals are of utmost interest for a non-stressed life. WSM which records heart muscle activities could signalize timely a life-threatening event. The heart muscle activities are typically recorded across the heart at the surface of the body; hence, a WSM monitor requires high-quality surface electrodes. The electrodes used in the clinical settings [i.e. silver/silver chloride (Ag/AgCl) with the gel] are not practi...
Source: Biomedizinische Technik/Biomedical Engineering - April 3, 2020 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

En Bloc Autotransplantation of Retained Canine in the Mandible: A Case Presentation.
Authors: Krasny M, Krasny K, Wojtowicz A Abstract Missing canines compromise function and esthetics and therefore should be restored. In case of a retained canine, there can be a conservative approach of classic orthodontic eruption. If that is not effective, an alternative treatment method is to remove the retained tooth, followed by implant placement or transalveolar autotransplantation of the retained canine. En bloc autotransplantation of a retained canine, with surrounding bone, preserves canine periodontium and increases chances for revascularization and vitality of the transplanted tooth. This paper presents...
Source: International Journal of Periodontics and Restorative Dentistry - April 3, 2020 Category: Dentistry Tags: Int J Periodontics Restorative Dent Source Type: research

[ASAP] Base-Promoted C –O Bond Cleavage of Primary Alcohols by Iridium(III) Porphyrin Chloride
OrganometallicsDOI: 10.1021/acs.organomet.0c00100 (Source: Organometallics)
Source: Organometallics - April 3, 2020 Category: Chemistry Authors: Yongjun Bian †‡, Xingyu Qu†‡, and Kin Shing Chan*‡§ Source Type: research

Protein kinase A phosphorylation potentiates cystic fibrosis transmembrane conductance regulator gating by relieving autoinhibition on the stimulatory C terminus of the regulatory domain [Protein Structure and Folding]
Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel activated by protein kinase A (PKA) phosphorylation on the regulatory (R) domain. Phosphorylation at several R domain residues stimulates ATP-dependent channel openings and closings, termed channel gating. To explore the protein segment responsible for channel potentiation and PKA-dependent activation, deletion mutations were constructed by removing one to three protein segments of the R domain including residues 708–759 (ΔR708–759), R760–783, and R784–835, each of which contains one or two PKA phosphorylation sit...
Source: Journal of Biological Chemistry - April 3, 2020 Category: Chemistry Authors: Jeng-Haur Chen Tags: Membrane Biology Source Type: research

Design of enamides as new selective monoamine oxidase ‐B inhibitors
ConclusionsThese results encourage further studies on the enamide scaffold as potential drug candidates for the treatment of Alzheimer's and Parkinson's diseases. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - April 3, 2020 Category: Drugs & Pharmacology Authors: Fathima Sahla Kavully, Jong Min Oh, Sanal Dev, Swafvan Kaipakasseri, Ashique Palakkathondi, Ajeesh Vengamthodi, Rinshana Fathima Abdul Azeez, Anna Rita Tondo, Orazio Nicolotti, Hoon Kim, Bijo Mathew Tags: Research Paper Source Type: research

Stripping and plating magnesium metal anode in bromide-based non-nucleophilic electrolytes.
We present here a new electrolyte formulation of non-nucleophilic HMDS magnesium containing bromide as halide instead of chloride, obtained via a simple and straightforward synthesis route and investigate the electrochemistry of magnesium through plating and stripping in three different HMDSBr-based electrolytes: Mg(HMDS)Br, Mg(HMDS)Br-BEt3 and Mg(HMDS)Br-AlEt3 dissolved in THF. We determine the different magnesium species in the electrolytes using NMR. Weak electron-withdrawing Lewis acids, BEt3 and AlEt3 were used intentionally and their impacts investigated. Contrary to expectation, substitution of chloride by bromide d...
Source: ChemSusChem - April 3, 2020 Category: Chemistry Authors: Dongmo S, Zaubitzer S, Schüler P, Krieck S, Jörissen L, Wohlfahrt-Mehrens M, Westerhausen M, Marinaro M Tags: ChemSusChem Source Type: research

Inhibition of TMEM16A suppresses growth and induces apoptosis in hepatocellular carcinoma
ConclusionOur data indicate that TMEM16A may represent a novel biomarker of HCC and may be a potential therapeutic target for diagnosis and therapy. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - April 2, 2020 Category: Cancer & Oncology Source Type: research

Sanggenon C Ameliorates Cerebral Ischemia-Reperfusion Injury by Inhibiting Inflammation and Oxidative Stress through Regulating RhoA-ROCK Signaling
AbstractSanggenon C (SC), a natural flavonoid extracted from Cortex Mori (Sang Bai Pi), is reported to possess anti-inflammatory and antioxidant properties in hypoxia. The present study aimed to investigate the therapeutic potential and the underlying mechanisms of SC in cerebral ischemia-reperfusion (I/R) injury. A rat model of reversible middle cerebral artery occlusion (MCAO) was used to induce cerebral I/R injuryin vivo, and SC was administrated intragastrically. Brain injuries were evaluated using Bederson scores, brain water content, and 2, 3, 5-triphenyltetrazolium chloride (TTC) staining. The levels of inflammatory...
Source: Inflammation - April 2, 2020 Category: Allergy & Immunology Source Type: research

A case of GABRA5-related developmental and epileptic encephalopathy with response to a combination of antiepileptic drugs and a GABAering agent
We report on a four-year and six-month-old girl with epilepsy and global developmental delay. Serial head growth measurement revealed postnatal onset microcephaly. (Source: Brain and Development)
Source: Brain and Development - April 2, 2020 Category: Neurology Authors: Ponghatai Boonsimma, Sirorat Suwannachote, Chureerat Phokaew, Chupong Ittiwut, Kanya Suphapeetiporn, Vorasuk Shotelersuk Tags: Case Report Source Type: research

Synthesis of new Enrofloxacin Derivatives as potential antibiofilm drugs against Staphylococcus aureus and Klebsiella pneumoniae.
CONCLUSION: These compounds can be used alone or with FDA approved drugs to overcome biofilm related K. pneumoniae and S. aureus infections. PMID: 32238140 [PubMed - as supplied by publisher] (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - April 2, 2020 Category: Chemistry Authors: Siddiqui H, Haniffa HM, Ahmed A, Choudhary MI Tags: Med Chem Source Type: research

Omega Rhodopsins: A Versatile Class of Microbial Rhodopsins.
Abstract Microbial rhodopsins are a superfamily of photoactive membrane proteins with covalently bound retinal cofactor. Isomerization of the retinal chromophore upon absorption of a photon triggers conformational changes of the protein to function as ion pumps or sensors. After the discovery of proteorhodopsin in an uncultivated γ-proteobacterium, light-activated proton pumps have been widely detected among marine bacteria and, together with chlorophyll-based photosynthesis, are considered as an important axis responsible for primary production in the biosphere. Rhodopsins and related proteins show a high l...
Source: Journal of Microbiology and Biotechnology - April 2, 2020 Category: Biotechnology Authors: Kwon SK, Jun SH, Kim JF Tags: J Microbiol Biotechnol Source Type: research

Multianalytical approach of stay-in-place polyvinyl chloride formwork concrete exposed to high temperatures
Publication date: Available online 31 March 2020Source: Journal of Materials Research and TechnologyAuthor(s): Leandro Gómez-Plata, Bernardo F. Tutikian, Fernanda Pacheco, Marcos S. Oliveira, Michel Murillo, Luis F.O. Silva, Carlos P. Bergmann (Source: Journal of Materials Research and Technology)
Source: Journal of Materials Research and Technology - April 1, 2020 Category: Materials Science Source Type: research

Preparation and digestive characteristics of a novel soybean lipophilic protein-hydroxypropyl methylcellulose-calcium chloride thermosensitive emulsion gel
Publication date: Available online 31 March 2020Source: Food HydrocolloidsAuthor(s): Mingming Zhong, Fengying Xie, Shuang Zhang, Yufan Sun, Baokun Qi, Yang Li (Source: Food Hydrocolloids)
Source: Food Hydrocolloids - April 1, 2020 Category: Food Science Source Type: research

Matrix isolation investigation of the wavelength-dependent photochemical reaction of ozone with vinyl chloride
Publication date: Available online 31 March 2020Source: Journal of Molecular StructureAuthor(s): Bruce S. Ault (Source: Journal of Molecular Structure)
Source: Journal of Molecular Structure - April 1, 2020 Category: Molecular Biology Source Type: research

Li Deposited on LiCl: An Efficient Reducing Agent
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ01010C, LetterXiaojun Su, Leif Laperriere, Caleb Daniel Martin Lithium was deposited onto lithium chloride powder in a ~5% weight/weight ratio. This material serves as a source of elemental lithium with benefits over bulk lithium alternatives including increased mass... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 1, 2020 Category: Chemistry Authors: Xiaojun Su Source Type: research

Hypochloremia at Left Ventricular Assist Device Implantation is Associated with Decreased One Year Survival
Serum chloride has been independently and inversely associated with mortality in acute decompensated heart failure. The impact of serum chloride on other subsets of the heart failure population is unclear. We sought to investigate the effects of hypochloremia in patients undergoing left ventricular assist device (LVAD) implantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2020 Category: Transplant Surgery Authors: V. Trovato, H. Singh, S. Smith Tags: (873) Source Type: research

Molecules, Vol. 25, Pages 1619: Choline Chloride Based Natural Deep Eutectic Solvents as Extraction Media for Extracting Phenolic Compounds from Chokeberry (Aronia Melanocarpa)
jnc Mitja Kolar For the isolation of selected phenolic compounds from dried chokeberries, natural deep eutectic solvents (NADESs) were investigated as a green alternative to conventionally used extraction solvents. Four types of NADESs were synthesised, with choline chloride as the hydrogen bond acceptor in combination with different hydrogen bond donors (sugars, organic acid and urea). Ultrasound-assisted extraction was used to improve the extractability of the phenolic compounds and the results were compared to those obtained with 80% methanol as the extraction media. The highest values of total phenols and total f...
Source: Molecules - April 1, 2020 Category: Chemistry Authors: Ma ša Islamčević Razboršek Milena Ivanovi ć Peter Krajnc Mitja Kolar Tags: Article Source Type: research

An LC/MS/MS method for analyzing the steroid metabolome with high accuracy and from small serum samples [Methods]
Analyzing global steroid metabolism in humans can shed light on the etiologies of steroid-related diseases. However, existing methods require large amounts of serum and lack the evaluation of accuracy. Here, we developed an LC/MS/MS method for the simultaneous quantification of 12 steroid hormones: testosterone, pregnenolone, progesterone, androstenedione, corticosterone, 11-deoxycortisol, cortisol, 17-hydroxypregnenolone, 17-hydroxyprogesterone, dehydroepiandrosterone, estriol, and estradiol. Steroids and spiked internal standards in 100 μl serum were extracted by protein precipitation and liquid-liquid extraction. The...
Source: The Journal of Lipid Research - April 1, 2020 Category: Lipidology Authors: Yuan, T.-F., 袁;腾;飞;, , Le, J., 乐;娟;, , Wang, S.-T., 王;少;亭;, , Li, Y., 李;艳;, Tags: Methods Source Type: research

Solubility of CO2 in three cellulose ‐dissolving ionic liquids
This article is protected by copyright. All rights reserved. (Source: AIChE Journal)
Source: AIChE Journal - April 1, 2020 Category: Science Authors: Eduardo P érez, Laura Pablo, J. Juan Segovia, Alejandro Moreau, Francisco A. Sánchez, Selva Pereda, María Dolores Bermejo Tags: THERMODYNAMICS AND MOLECULAR ‐SCALE PHENOMENA Source Type: research

Unprecedented reductive cyclisation of salophen ligands to tetrahydroquinoxalines during metal complex formation.
Abstract The synthesis of novel tetrahydroquinoxalines by a metal induced one-electron reductive cyclisation of salophen ligands was found to occur when a salophen ligand was treated with chromium(ii) chloride or decamethylcobaltocene. PMID: 32236256 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - April 1, 2020 Category: Chemistry Authors: Lamb KJ, Dowsett MR, North M, Parker RR, Whitwood AC Tags: Chem Commun (Camb) Source Type: research

Label-free graphene oxide-based SPR genosensor for the quantification of microRNA21.
F, Rivas G Abstract This work is focused on the development of a genosensor for microRNA-21 quantification using surface plasmon resonance (SPR) to transduce the hybridization event. The biosensing platform was built by self-assembling two bilayers of poly(diallyldimethylammonium chloride) (PDDA) and graphene oxide (GO) at a gold surface modified with 3-mercaptopropane sulfonate (MPS), followed by the covalent attachment of the DNA probe. GO was used in two directions, to allow the anchoring of the probe DNA and to increase the sensitivity of the biosensing event due to its field enhancer effect. The new bioanaly...
Source: Analytical and Bioanalytical Chemistry - April 1, 2020 Category: Chemistry Authors: Mujica ML, Zhang Y, Bédioui F, Gutiérrez F, Rivas G Tags: Anal Bioanal Chem Source Type: research

Linkage between fluorescence and electrochemical properties of imidazolium compounds in acetonitrile solution.
rtínez D, González FJ Abstract The fluorescence properties of some imidazolium derivatives are relevant in photosensing and therefore, the structural analysis of them is a key point for its rational design, which would be useful to prepare new systems with novel applications. Herein we report a multidisciplinary study of the fluorescence and voltammetric properties of three imidazolium compounds {1,3-bis[(R,R)-1'-chloro-1'-phenylpropan-2'-yl]-imidazolium chloride ( 1 ), 1,3-bis[(Z)-1'-phenylprop-1'-en-2'-yl]imidazolium chloride ( 2 ) 1,3-bis[(R)-1'-chlorobutan-2'-yl]-imidazolium chloride ( 3 )}. Elec...
Source: Chemphyschem - April 1, 2020 Category: Chemistry Authors: Flores-Parra A, Villaseñor-Granados TO, Rodríguez-López G, Ramos-García I, Morales-Martínez D, González FJ Tags: Chemphyschem Source Type: research

TRPA1 causes rapid bronchodilation via non-epithelial PGE2.
Abstract Transient Potential Receptor Ankyrin 1 (TRPA1) is a ligand-gated cation channel that responds to endogenous and exogenous irritants. TRPA1 is expressed on multiple cell types throughout the lungs, but previous studies have primarily focused on TRPA1 stimulation of airway sensory nerves. We sought to understand the integrated physiologic airway response to TRPA1 stimulation. The TRPA1 agonists allyl isothiocyanate (AITC) and cinnamaldehyde (CINN) were tested in sedated, mechanically ventilated guinea pigs in vivo. Reproducible bronchoconstrictions were induced by electrical stimulation of the vagus nerves....
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 1, 2020 Category: Cytology Authors: Marsh BJ, Fryer AD, Jacoby DB, Drake MG Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

[ASAP] How Does Addition of Lithium Salt Influence the Structure and Dynamics of Choline Chloride-Based Deep Eutectic Solvents?
The Journal of Physical Chemistry BDOI: 10.1021/acs.jpcb.9b11947 (Source: Journal of Physical Chemistry B)
Source: Journal of Physical Chemistry B - March 31, 2020 Category: Chemistry Authors: Sahadev Barik, Manjari Chakraborty, and Moloy Sarkar* Source Type: research

Crystal structure, Hirshfeld surface analysis and computational study of 2-chloro-N-[4-(methylsulfanyl)phenyl]acetamide
In the title compound, C9H10ClNOS, the amide functional group – C(=O)NH – adopts a trans conformation with the four atoms nearly coplanar. This conformation promotes the formation of a C(4) hydrogen-bonded chain propagating along the [010] direction. The central part of the molecule, including the six-membered ring, the S and N atoms, is fairly planar (r.m.s. deviation of 0.014). The terminal methyl group and the C(=O)CH2 group are slightly deviating out-of-plane while the terminal Cl atom is almost in-plane. Hirshfeld surface analysis of the title compound suggests that the most significant contacts in the cry...
Source: Acta Crystallographica Section E - March 31, 2020 Category: Chemistry Authors: Mongkholkeaw, S. Songsasen, A. Duangthongyou, T. Chainok, K. Suramitr, S. Wattanathana, W. Wannalerse, B. Tags: 4-methylthioaniline chloroacetyl chloride hydrogen bonds π – interactions crystal structure research communications Source Type: research

The Melatonin Receptor Agonist Ramelteon Induces Cardioprotection that Requires MT2 Receptor Activation and Release of Reactive Oxygen Species
ConclusionsThis study shows for the first time that despite the higher affinity to MT1 receptors, (1) ramelteon-induced cardioprotection involves MT2 receptors, (2) cardioprotection requires ROS release, and (3) inhibition of the mPTP can restore infarct size reduction. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - March 31, 2020 Category: Cardiology Source Type: research

Elimination of elemental mercury in flue gas by Arachis hypogaea Linn. shell generated activated carbon.
This study provided a practical and easy preparation method of bio-activated carbon for Hg0 removal with low cost. Graphical Abstract. PMID: 32236807 [PubMed - as supplied by publisher] (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - March 31, 2020 Category: Environmental Health Authors: Duan X, Yuan CG, Jing T, Yuan X, Xie J Tags: Environ Sci Pollut Res Int Source Type: research

Geraniol attenuates oxidative stress, bioaccumulation, serological and histopathological changes during aluminum chloride-hepatopancreatic toxicity in male Wistar rats.
Abstract Aluminum chloride (AlCl3) has different industrial applications including manufacturing paint and water treatment. The present study was designed to evaluate the alleviating effect of geraniol against AlCl3-induced hepatopancreatic toxicity. To this end, forty male Wistar rats were divided into control (0.9% NaCl, IP), geraniol (100 mg/kg orally), AlCl3 (70 mg/kg, IP), and AlCl3 (70 mg/kg, IP) plus geraniol (100 mg/kg orally) groups and then were treated daily for 28 days. Based on the results, serum cholesterol, triglyceride, as well as liver and pancreas enzymes increased significantly (P 
Source: Environmental Science and Pollution Research International - March 31, 2020 Category: Environmental Health Authors: Hosseini SM, Hejazian LB, Amani R, Siahchehreh Badeli N Tags: Environ Sci Pollut Res Int Source Type: research

Importance of Tyr409 and Tyr414 in constructing the substrate pocket of human aminopeptidase B.
In this study, we further searched for residues critical to its enzymatic activity, especially toward peptide substrates. APB residues Tyr409 (Y409) and Tyr414 (Y414), both of which were critical to its hydrolytic activity toward synthetic substrates, were predicted by molecular modeling to be involved in cleaving peptide substrates via its interaction with amino acids in the P1' cleavage site. Using site-directed mutagenesis, several mutant APBs were prepared. In contrast to synthetic substrates, wild-type and Y409F/Y414F double mutant enzymes showed P1'-dependent cleavage of peptide substrates, indicating that both tyros...
Source: Molecular and Cellular Biochemistry - March 31, 2020 Category: Biochemistry Authors: Ohnishi A, Watanabe J, Tsujimoto M Tags: Mol Cell Biochem Source Type: research

Salalen vs. thiolen: in the ring(-opening of epoxide and cyclic carbonate formation)
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Oliver J. Driscoll, Jack A. Stewart, Paul McKeown, Matthew Jones A range of Fe(III)-salalen and -thiolen-chloride complexes have been prepared and are shown to be active catalysts for the selective coupling of CO2 and cyclohexene oxide (CHO). The first Fe(III)-thiolen-acetate... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - March 30, 2020 Category: Chemistry Authors: Oliver J. Driscoll Source Type: research

Molecules, Vol. 25, Pages 1576: Model Optimization for the Prediction of Red Wine Phenolic Compounds Using Ultraviolet –Visible Spectra
Molecules, Vol. 25, Pages 1576: Model Optimization for the Prediction of Red Wine Phenolic Compounds Using Ultraviolet–Visible Spectra Molecules doi: 10.3390/molecules25071576 Authors: Chris Beaver Thomas S Collins James Harbertson The primary objective of this work was to optimize red wine phenolic prediction with models built from wine ultraviolet–visible absorbance spectra. Three major obstacles were addressed to achieve this, namely algorithm selection, spectral multicollinearity, and phenolic evolution over time. For algorithm selection, support vector regression, kernel ridge regressio...
Source: Molecules - March 30, 2020 Category: Chemistry Authors: Chris Beaver Thomas S Collins James Harbertson Tags: Article Source Type: research

Cystic fibrosis
(CF) is the most common autosomal recessive condition to affect white individuals. Defects in the CFTR chloride channel result in progressive organ dysfunction, particularly affecting the respiratory system. Patients require life-long care from multidisciplinary teams in specialist centres. Over time, improvements in screening and understanding of pathogenic alleles have increased diagnosis, while advances in management have led to better survival. The recent emergence of CFTR-modulating agents offers the potential to stabilize and improve lung disease, nutrition and quality of life in many people with CF. (Source: Medicine)
Source: Medicine - March 30, 2020 Category: Internal Medicine Authors: Alexandra E. Ewence, Andrew L. Jones Tags: Cystic fibrosis Source Type: research

Influence of Hydration on the Structure and Interactions of (Choline Chloride + Ethylene Glycol) Deep-Eutectic Solvent: A Spectroscopic and Computational study.
This study deepened our molecular-level understanding of the system and would shed light on its applications. PMID: 32232896 [PubMed - as supplied by publisher] (Source: Chemphyschem)
Source: Chemphyschem - March 30, 2020 Category: Chemistry Authors: Kalhor P, Zheng YZ, Ashraf H, Cao B, Yu ZW Tags: Chemphyschem Source Type: research

Regioselective sulfation of β-glucan from Ganoderma lucidum and structure-anticoagulant activity relationship of sulfated derivatives.
Regioselective sulfation of β-glucan from Ganoderma lucidum and structure-anticoagulant activity relationship of sulfated derivatives. Int J Biol Macromol. 2020 Mar 30;: Authors: Zhang Z, Tang Q, Wu D, Zhou S, Yang Y, Feng N, Tang C, Wang J, Yan M, Liu Y, Zhang J Abstract In the present study, regioselective sulfation of β-glucan (GLP) from Ganoderma lucidum were firstly established by using 4,4'-dimethoxytrityl chloride and hexamethyldisilazane as protecting precursor. 2,4,6-O-sulfated, 6-O-sulfated and 2,4-O-sulfated GLP derivatives were prepared and the molecular weights (Mw) of derivativ...
Source: International Journal of Biological Macromolecules - March 30, 2020 Category: Biochemistry Authors: Zhang Z, Tang Q, Wu D, Zhou S, Yang Y, Feng N, Tang C, Wang J, Yan M, Liu Y, Zhang J Tags: Int J Biol Macromol Source Type: research

Sodium N-lauryl amino acids derived from silk protein can form catanionic aggregates with cytarabine as novel anti-tumor drug delivery systems.
Authors: Zhang M, Zhao SX, Ding B, Zhang YQ Abstract A sodium N-lauryl amino acids (shortly silk sericin surfactant, SSS) is synthesized with lauryl chloride and sericin amino acids recovered from silk industrial waste. The purpose of this study is to explore whether the sericin surfactant can be used as a potential drug delivery carrier. By controlling the proportion of cationic drugs, cytarabine hydrochloride (CH) and anionic SSS, the aggregation behavior, slow release capability and toxicological effects of catanionic aggregates or vesicles, formed through CH and SSS, have been investigated in detail. Dynamic li...
Source: Drug Delivery - March 29, 2020 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research

Development and in-vitro evaluation of co-loaded berberine chloride and evodiamine ethosomes for treatment of melanoma
Publication date: Available online 27 March 2020Source: International Journal of PharmaceuticsAuthor(s): Hongmei Lin, Longfei Lin, Yoonsun Choi, Bozena Michniak-Kohn (Source: International Journal of Pharmaceutics)
Source: International Journal of Pharmaceutics - March 28, 2020 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 25, Pages 1544: Preparation of Nanocellulose Using Ionic Liquids: 1-Propyl-3-Methylimidazolium Chloride and 1-Ethyl-3-Methylimidazolium Chloride
tajczak Cellulose nanocrystals were prepared using ionic liquids (ILs), 1-ethyl-3-methylimidazolium chloride [EMIM][Cl] and 1-propyl-3-methylimidazolium chloride [PMIM][Cl], from microcrystalline cellulose. The resultant samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The XRD results showed that nanocellulose obtained by treatment with both ILs preserved basic cellulose I structure, but crystallinity index of samples (except for Sigmacell treated with [EM...
Source: Molecules - March 28, 2020 Category: Chemistry Authors: Marta Babicka Magdalena Wo źniak Krzysztof Dwiecki S ławomir Borysiak Izabela Ratajczak Tags: Article Source Type: research

Viruses, Vol. 12, Pages 374: Development of a Honey Bee RNA Virus Vector Based on the Genome of a Deformed Wing Virus
Jay D. Evans We developed a honey bee RNA-virus vector based on the genome of a picorna-like Deformed wing virus (DWV), the main viral pathogen of the honey bee (Apis mellifera). To test the potential of DWV to be utilized as a vector, the 717 nt sequence coding for the enhanced green fluorescent protein (eGFP), flanked by the peptides targeted by viral protease, was inserted into an infectious cDNA clone of DWV in-frame between the leader protein and the virus structural protein VP2 genes. The in vitro RNA transcripts from egfp-tagged DWV cDNA clones were infectious when injected into honey bee pupae. Stable DWV part...
Source: Viruses - March 28, 2020 Category: Virology Authors: Eugene V. Ryabov Krisztina Christmon Matthew C. Heerman Francisco Posada-Florez Robert L. Harrison Yanping Chen Jay D. Evans Tags: Article Source Type: research

Triglyceride is a Good Biomarker of Increased Injury Severity on a High Fat Diet Rat After Traumatic Brain Injury.
Abstract Injury severity is correlated with poor prognosis after traumatic brain injury (TBI). It is not known whether triglycerides (TGs) or total cholesterol (TC) is good biomarker of increased injury of neuroinflammation and apoptosis in a high fat diet (HFD)-treated rat after TBI episodes. Five-week-old male Sprague-Dawley (SD) rats were fed a HFD for 8 weeks. The anesthetized male SD rats were divided into three sub-groups: sham-operated and TBI with 1.6 atm or with 2.4 atm fluid percussion injury (FPI). Cell infarction volume (triphenyltetrazolium chloride stain), tumor necrosis factor-alpha (...
Source: Neurochemical Research - March 28, 2020 Category: Neuroscience Authors: Kuo JR, Lim SW, Zheng HX, Ho CH, Chang CH, Chio CC, Wee HY Tags: Neurochem Res Source Type: research

Synthesis of C17-[5-methyl-1,3]-oxazoles by N-propargylation of triterpenic acids and evaluation of their cytotoxic activity.
Abstract A series of unexpected triterpenic C17-[5-methyl-1,3]-oxazoles along with targeted N-propargylamides was synthesized by an interaction of acid chlorides with propargylamine hydrochloride. We proposed that the formation of methyl oxazole passes through an alternative pathway by the participation of the terminal alkyne carbon atom and acid chloride intermediate with following intramolecular rearrangements. The synthesized compounds were evaluated for their cytotoxicity at the U.S. National Cancer Institute. 28-Nor-17-(5-methyloxazol-2-yl)-2-cyano-2,4-seco-3-nor-lup-4(23),20(29)-diene has demonstrated the hi...
Source: Natural Product Research - March 28, 2020 Category: Biochemistry Authors: Khusnutdinova EF, Petrova AV, Lobov AN, Kukovinets OS, Baev DS, Kazakova OB Tags: Nat Prod Res Source Type: research

New alginate-based interpenetrating polymer networks for water treatment: A response surface methodology based optimization study.
Abstract Different interpenetrating polymeric networks (IPN) based on sodium alginate, carrageenan and bentonite were developed to remove heavy metals and dyes from contaminated water. Four significant preparation factors; crosslinking time, calcium chloride concentration, alginate to carrageenan mass ratio,and bentonite to carrageenan mass ratio were studied and optimized via full factorial design and response surface methodology to determine the optimum composition with highest adsorption capacity. Different optimal conditions and combinations were found depending on the type of heavy metal or dye to be removed....
Source: International Journal of Biological Macromolecules - March 28, 2020 Category: Biochemistry Authors: Al-Sakkari EG, Abdeldayem OM, Genina EE, Amin L, Bahgat NT, Rene ER, El-Sherbiny IM Tags: Int J Biol Macromol Source Type: research

The anionic recognition mechanism based on polyol and boronic acid receptors
New J. Chem., 2020, Advance Article DOI: 10.1039/C9NJ06200A, PaperRenato Pereira Orenha, Claudia Haber Cintra, Let ícia Bermudes Peixoto, Éder Henrique da Silva, Giovanni Finoto Caramori, Alexandre Osmar Ortolan, Maurício Jeomar Piotrowski, Renato Luis Tame Parreira Chloride, fluoride, dihydrogen phosphate, acetate, bromide, and hydrogen sulfate recognition from polyol and boronic acid receptors is elucidated. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - March 27, 2020 Category: Chemistry Authors: Renato Pereira Orenha Source Type: research

A simple method for quantifying iodate and iodide fractions in solution using Ag + -impregnated activated carbon
In this study, the utilization of silver-impregnated granular activated carbon for separation between two iodine species, iodate and iodide, from each other was studied in different solution matrices with batch and column experiments. A high separation of the iodine species was achieved in the high concentrations of interfering ions, e.g. chloride, and in both μM and trace iodine concentrations. The method is suitable for both radioactive and non-radioactive iodine. (Source: Journal of Radioanalytical and Nuclear Chemistry)
Source: Journal of Radioanalytical and Nuclear Chemistry - March 27, 2020 Category: Nuclear Medicine Source Type: research

Synthesis of triphenylene-fused phosphole oxides via C – H functionalizations
Abstract The synthesis of triphenylene-fused phosphole oxides has been achieved through two distinct C–H functionalization reactions as key steps. The phosphole ring was constructed by a three-component coupling of 3-(methoxymethoxy)phenylzinc chloride, an alkyne, and dichlorophenylphosphine, involving the regioselective C–H activation of the C2 position of the arylzinc intermediate via 1,4-cobalt migration. The resulting 7-hydroxybenzo[b]phosphole derivative was used for further π-extension through Suzuki–Miyaura couplings and a Scholl reaction, the latter closing the triphenylene ring. The absorption...
Source: Beilstein Journal of Organic Chemistry - March 27, 2020 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: C – H functionalization fluorescence phosphole polycyclic aromatic hydrocarbons triphenylene Letter Source Type: research

TFAM, a potential oxidative stress biomarker used for monitoring environment pollutants in Musca domestica.
Abstract Mitochondrial transcription factor A (TFAM) plays a key role in regulating the transcription, replication, and maintenance of mitochondrial DNA. In the present study, a Musca domestica TFAM (MdTFAM) gene was identified and characterized. MdTFAM gene encodes 253 amino acid residues, and the protein possesses two conserved motifs of HMG (High Mobility Group) box. Expression of MdTFAM was investigated based on the qRT-PCR (quantitative real-time polymerase chain reaction) in response to three model oxidative stress-inducing agents, cadmium chloride (Cd), doxorubicin hydrochloride (DOX) and ultraviolet (UV), ...
Source: International Journal of Biological Macromolecules - March 27, 2020 Category: Biochemistry Authors: Feng Q, Shao M, Han J, Tang T, Zhang Y, Liu F Tags: Int J Biol Macromol Source Type: research

Enhancement of Apx toxin production in Actinobacillus pleuropneumoniae serotypes 1, 2, and 5 by optimizing culture conditions.
Abstract Actinobacillus pleuropneumoniae (APP) is a causative agent of porcine pleuropneumonia. Therefore, the development of an effective vaccine for APP is necessary. Here, we optimized the culture medium and conditions to enhance the production yields of Apx toxins in APP serotype 1, 2, and 5 cultures. The use of Mycoplasma Broth Base (PPLO) medium improved both the quantity and quality of the harvested Apx toxins compared with Columbia Broth (CB) medium. Calcium chloride (CaCl2) was first demonstrated as a stimulation factor for the production of Apx toxins in APP serotype 2 cultures. Cultivation of APP seroty...
Source: Journal of Microbiology and Biotechnology - March 27, 2020 Category: Biotechnology Authors: Dao HT, Do VT, Truong QL, Hahn TW Tags: J Microbiol Biotechnol Source Type: research

Phase equilibrium systems of cadmium {chloride + L–serine(glycine) +water} at 298.15K and standard molar enthalpy of formation of Cd(C3H7NO3)Cl2∙H2O and Cd(C2H5NO2)2Cl2
Publication date: Available online 26 March 2020Source: The Journal of Chemical ThermodynamicsAuthor(s): Qi-Chao Yang, Yuan-Lin Dang, Zhan-Ping Qiao (Source: The Journal of Chemical Thermodynamics)
Source: The Journal of Chemical Thermodynamics - March 26, 2020 Category: Chemistry Source Type: research