Inconsequential role for chemerin ‐like receptor 1 in the manifestation of ozone‐induced lung pathophysiology in male mice
AbstractWe executed this study to determine if chemerin-like receptor 1 (CMKLR1), aGi/o protein-coupled receptor expressed by leukocytes and non-leukocytes, contributes to the development of phenotypic features of non-atopic asthma, including airway hyperresponsiveness (AHR) to acetyl- β-methylcholine chloride, lung hyperpermeability, airway epithelial cell desquamation, and lung inflammation. Accordingly, we quantified sequelae of non-atopic asthma in wild-type mice and mice incapable of expressing CMKLR1 (CMKLR1-deficient mice) following cessation of acute inhalation exposure t o either filtered room air (air) or ozone ...
Source: Physiological Reports - April 18, 2024 Category: Physiology Authors: Richard A. Johnston,
Albert W. Pilkington IV,
Constance L. Atkins,
Theresa E. Boots,
Philip L. Brown,
William T. Jackson,
Chantal Y. Spencer,
Saad R. Siddiqui,
Ikram U. Haque Tags: ORIGINAL ARTICLE Source Type: research
Uremia Impedes Skeletal Myocyte Myomixer Expression and Fusogenic Activity
In patients with chronic kidney disease (CKD), skeletal muscle mass and function are known to occasionally decline. However, the muscle regeneration and differentiation process in uremia has not been extensively studied. In mice with CKD induced by adenine-containing diet, the tibialis anterior muscle injured using a barium chloride injection method recovered poorly as compared to control mice. In the cultured murine skeletal myocytes, stimulation with indoxyl sulfate (IS), a representative uremic toxin, morphologically jeopardized the differentiation, which was counteracted by L-ascorbic acid (L-AsA) treatment. (Source: A...
Source: American Journal of Pathology - April 17, 2024 Category: Pathology Authors: Takaaki Higashihara, Motoki Odawara, Hiroshi Nishi, Takehito Sugasawa, Yumika Suzuki, Satoshi Kametaka, Reiko Inagi, Masaomi Nangaku Tags: Regular Article Source Type: research
Cardioprotective Effects of Aloysia polystachya Essential Oil on a Rat Model with Multiple Cardiovascular Risk Factors
This study aimed to investigate the protective effects of the essential oil extracted from the leaves of A. polystachya in a rat model that simulates multiple cardiovascular risk factors. We evaluate the acute toxicity, as well as the cardioprotective effects, by giving different doses of A. polystachya essential oil (1.47 mg/kg, 4.40 mg/kg, and 13.20 mg/kg) over a period of 42 days. The control group was treated with rosuvastatin (5 mg/kg). At the end of the treatments, the renal function, electrocardiography, blood pressure, vascular reactivity, serum biochemical profile, and organ histopathology were evaluated...
Source: Planta Medica - April 17, 2024 Category: Drugs & Pharmacology Authors: Moreno, Karyne Garcia Tafarelo Marques, Aline Aparecida Macedo da Silva, Gabriela Pereira Bertoncelo, Luana Ale Pessoal, Luciane Barbosa Gon çalves, Larissa Dantas dos Santos, Ariany Carvalho Souza, Roosevelt Isa ías Carvalho Silva, Denise Brentan Gaspa Tags: Original Papers Source Type: research
Submicron aerosol pollution in Greater Cairo (Egypt): A new type of urban haze?
Environ Int. 2024 Mar 27;186:108610. doi: 10.1016/j.envint.2024.108610. Online ahead of print.ABSTRACTGreater Cairo, the largest megacity of the Middle East North Africa (MENA) region, is currently suffering from major aerosol pollution, posing a significant threat to public health. However, the main sources of pollution remain insufficiently characterized due to limited atmospheric observations. To bridge this knowledge gap, we conducted a continuous 2-month field study during the winter of 2019-2020 at an urban background site, documenting for the first time the chemical and physical properties of submicron (PM1) aerosol...
Source: Environment International - April 16, 2024 Category: Environmental Health Authors: Aliki Christodoulou Spyros Bezantakos Efstratios Bourtsoukidis Iasonas Stavroulas Michael Pikridas Konstantina Oikonomou Minas Iakovides Salwa K Hassan Mohamed Boraiy Mostafa El-Nazer Ali Wheida Magdy Abdelwahab Roland Sarda-Est ève Martin Rigler Giorgos Source Type: research
< em > Z < /em > -selective radical difunctionalization of aromatic alkynes: synthesis of multi-substituted triarylethenes
Chem Commun (Camb). 2024 Apr 16. doi: 10.1039/d4cc01315h. Online ahead of print.ABSTRACTAn efficient method for the radical difunctionalization of aromatic alkynes has been developed, resulting in the synthesis of a range of valuable triarylethenes. This approach utilizes strategically designed aryldiazonium salts with tertiary alcohol substitution as bifunctional reagents, along with cost-effective cuprous chloride as a catalyst. The method demonstrates remarkable Z-selectivity and is capable of gram-scale preparation. Additionally, a novel spin-trapping reagent has been developed based on the synthesized product.PMID:386...
Source: Chemical Communications - April 16, 2024 Category: Chemistry Authors: Xinxin Wang Jie Wang Meishan Ji Xinxin Wu Chen Zhu Source Type: research
Anion-Coordination Foldamer-Based Polymer Network: from Molecular Spring to Elastomer
Angew Chem Int Ed Engl. 2024 Apr 16:e202400989. doi: 10.1002/anie.202400989. Online ahead of print.ABSTRACTFoldamer is a scaled-down version of coil spring, which can absorb and release energy by conformational change. Here, polymer networks with high-density of molecular springs were developed by employing anion-coordination-based foldamers as the monomer. The coiling of the foldamer is controlled by oligourea ligands coordinating to chloride ions; subsequently, the folding and unfolding of foldamer conformations endow the polymer network with excellent energy dissipation and toughness. The mechanical performance of the c...
Source: Angewandte Chemie - April 16, 2024 Category: Chemistry Authors: Jiangping Qin Yongming Wang Tian Wang Na Wang Wenhua Xu Lin Cheng Wei Yu Xuzhou Yan Lingyan Gao Bo Zheng Biao Wu Source Type: research
Selective Arylation of RNA 2'-OH Groups via SNAr Reaction with Trialkylammonium Heterocycles
Angew Chem Int Ed Engl. 2024 Apr 16:e202403496. doi: 10.1002/anie.202403496. Online ahead of print.ABSTRACTSmall-molecule reactions at the 2'-OH groups of RNA enable useful applications for transcriptome technology and biology. To date, all reactions have involved carbonyl acylation and mechanistically related sulfonylation, limiting the types of modifications and properties that can be achieved. Here we report that electron-deficient heteroaryl species selectively react with 2'-OH groups of RNA in water via SNAr chemistry. In particular, trialkyl-ammonium (TAA)-activated aromatic heterocycles, prepared in one step from ar...
Source: Angewandte Chemie - April 16, 2024 Category: Chemistry Authors: Sayantan Chatterjee Lu Xiao Wenrui Zhong Sheng Feng Eric T Kool Source Type: research
Depth-Specific Hypoxic Responses to Spreading Depolarizations in Gyrencephalic Swine Cortex Unveiled by Photoacoustic Imaging
AbstractSpreading depolarizations (SDs) are a marker of brain injury and have a causative effect on ischemic lesion progression. The hemodynamic responses elicited by SDs are contingent upon the metabolic integrity of the affected tissue, with vasoconstrictive reactions leading to pronounced hypoxia often indicating poor outcomes. The stratification of hemodynamic responses within different cortical layers remains poorly characterized. This pilot study sought to elucidate the depth-specific hemodynamic changes in response to SDs within the gray matter of the gyrencephalic swine brain. Employing a potassium chloride –indu...
Source: Translational Stroke Research - April 16, 2024 Category: Neurology Source Type: research
Skeletal rearrangement of 6,8-dioxabicyclo[3.2.1]octan-4-ols promoted by thionyl chloride or Appel conditions
Abstract
A skeletal rearrangement of a series of 6,8-dioxabicyclo[3.2.1]octan-4-ols has been developed using SOCl2 in the presence of pyridine. An oxygen migration from C5 to C4 was observed when the C4 alcohols were treated with SOCl2/pyridine, giving a 2-chloro-3,8-dioxabicyclo[3.2.1]octane ring-system via the chlorosulfite intermediate. Analogous allylic alcohols with endocyclic and exocyclic unsaturations underwent chlorination without rearrangement due to formation of allylic cations. The rearrangement was also demonstrated using Appel conditions, which gave similar results via the alkoxytriphenylphosphonium intermedi...
Source: Beilstein Journal of Organic Chemistry - April 16, 2024 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: bicyclic ring cyrene levoglucosenone rearrangement thionyl chloride Full Research Paper Source Type: research
High versus low chloride load in adult hyperglycemic emergencies with acute kidney injury, a multicenter retrospective cohort study: COMMENT
(Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - April 16, 2024 Category: Emergency Medicine Source Type: research
Optimization of salt ready-mix for instant fried noodles production using response surface methodology
This study aims to provide a salt ready-mix to instant fried noodles manufacturers.Response surface methodology was used to get optimized salt ready-mix based on carbonate salt, disodium phosphate, tripotassium phospahte, sodium hexametaphosphate and sodium chloride. Peak viscosity of flour and yellowness, cooking loss and hardness of noodles were considered as response factors for finding optimized salt formulation.The results showed that salts have an important role in governing quality of noodles. Optimum levels of five independent variables of salts, namely, carbonate salt (1:1 mixture of sodium to potassium carbonate)...
Source: Nutrition and Food Science - April 15, 2024 Category: Nutrition Authors: Manisha Malik Devyani Tomar Narpinder Singh B.S. Khatkar Source Type: research
< em > CLCN3 < /em > in mediating the proliferation of human ovarian cancer cells
CONCLUSIONS: CLCN3 is a possible biomarker for immune-related processes and the prognosis of cancer, and the PI3K/AKT signaling pathway may affect OC cells' ability to proliferate.PMID:38617512 | PMC:PMC11009797 | DOI:10.21037/tcr-23-1272 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Lufei Ren Yuyang Li Yifan Feng Zhe Zhang Huijun Yang Min Li Source Type: research
Ameliorative anti-coagulant, anti-oxidative and anti-ferroptotic activities of nanocurcumin and donepezil on coagulation, oxidation and ferroptosis in Alzheimer's disease
The objective of the current investigation was to examine the neuroprotective and anti-ferroptotic role of nanocurcumin and Donepezil against model of aluminum chloride AlCl3 and D-galactose induced ad. The experiment was performed on 70 rats divided into (G1: control, G2: NCMN, G3: Donepezil, G4: ad-model, G5: Donepezil co-treatment, G6: NCMN co-treatment and G7: NCMN+Donepezil co-treatment). Hematological parameters and biochemical investigations as oxidative stress, liver function, kidney function, iron profile and plasma fibrinogen were evaluated. Treatment with Nanocurcumin alone or in combination with Donepezil impro...
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Nagat F Nawar Doha M Beltagy Tarek M Mohamed Ehab Tousson Mai M El-Keey Source Type: research
Bioremediation of 2,4,6-trichlorophenol by extracellular enzymes of white rot fungi immobilized with sodium alginate/hydroxyapatite/chitosan microspheres
Environ Res. 2024 Apr 13:118937. doi: 10.1016/j.envres.2024.118937. Online ahead of print.ABSTRACTHydroxyapatite, a calcium phosphate biomass material known for its excellent biocompatibility, holds promising applications in water, soil, and air treatment. Sodium alginate/hydroxyapatite/chitosan (SA-HA-CS) microspheres were synthesized by cross-linking sodium alginate with calcium chloride. These microspheres were carriers for immobilizing extracellular crude enzymes from white rot fungi through adsorption, facilitating the degradation of 2,4,6-trichlorophenol (2,4,6-TCP) in water and soil. At 50 oC, the immobilized enzyme...
Source: Environmental Research - April 15, 2024 Category: Environmental Health Authors: Jing Wu Dawen Gao Litao Wang Xuran Du Zhou Zhang Hong Liang Source Type: research
A Single Standard Polyvinyl Chloride 3D Skull Model to Create the Polymethyl Methacrylate Cranioplasty Flap: A Novel and Low-Cost Technique
Conclusion Our technique provides excellent functional and cosmetic outcomes. The overall surgical cost of these PMMA implants was lower than that of the other available cranioplasty implants. This technique is currently the most cost-effective option for cranioplasty. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Journal of Neurological Surgery Part A: Central European Neurosurgery)
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - April 15, 2024 Category: Neurosurgery Authors: Prajapati, Hanuman Prasad Singh, Deepak Kumar Tags: Original Article Source Type: research
