Antiviral Mechanism and Clinical Benefits of Mouthwash Active Against SARS-CoV-2

 Reia, V.C.B., da Fonseca Orcina, B., Vilhena, F.V.et al. Antiviral Mechanism and Clinical Benefits of Mouthwash Active Against SARS-CoV-2.Curr Oral Health Rep (2024). https://doi.org/10.1007/s40496-024-00368-1AbstractPurpose of ReviewWe
aim to review the spectrum of biological mechanisms of mouthwashes
shown to be active against SARS-CoV-2, evidence for efficacy in
reduction of viral load, in vitro and in vivo, and the potential for
clinical benefit in use of mouthwashes in the context of COVID-19.Recent FindingsNumerous
studies have now been performed to establish the antiviral efficacy of
specific mouthwash ingredients against SARS-CoV-2. A combination of
biological in vitro studies and clinical studies which assess reduction
of viral load in vivo have been performed. Certain mouthwash ingredients
have been shown to have anti-SARS-CoV-2 effect, both in vitro and in
vivo, for example, by reducing viral load detectable in saliva during
acute COVID-19 infection. In addition, iron phthalocyanine, which has
antibacterial, antifungal, and antiviral properties, has been tested
using in vitro tests, cross-sectional population studies, and randomized
clinical trials to assess clinical benefit of its use in the context of
hospitalized patients with COVID-19.SummaryA
non-systematic search of the literature was conducted to find studies
which generally investigated the mechanisms of action of specific
mouthwash ingredients including chlorhexidine (CHX), cetylpyr...

Source: Dental Technology Blog - February 19, 2024 Category: Dentistry Source Type: news