Estimated SARS-CoV-2 Seroprevalence Among Persons Aged < 18 Years - Mississippi, May-September 2020
This report describes trends in SARS-CoV-2 antibody seroprevalence among young persons in Mississippi during the COVID-19 pandemic. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - March 4, 2021 Category: American Health Tags: MMWR Morbidity & Mortality Weekly Report SARS (Severe acute respiratory syndrome) COVID-19 Source Type: news

SARS-CoV-2 Infection Risk Among Active Duty Military Members Deployed to a Field Hospital - New York City, April 2020
This report describes rates of COVID-19 infection among U.S. military personnel deployed to a New York City field hospital. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - March 4, 2021 Category: American Health Tags: MMWR Morbidity & Mortality Weekly Report SARS (Severe acute respiratory syndrome) COVID-19 Source Type: news

Intimate partner violence during the confinement period of the COVID-19 pandemic: exploring the French and Cameroonian public health policies - Tochie JN, Ofakem I, Ayissi G, Endomba FT, Fobellah NN, Wouatong C, Temgoua MN.
Coronavirus disease (COVID-19) is an unprecedented pandemic. COVID-19 is a highly contagious and potentially fatal respiratory infection which has spread within three months of its outbreak to more than 173 countries, causing 3.7 million infections and 256... (Source: SafetyLit)
Source: SafetyLit - March 4, 2021 Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news

Association between chronic fatigue syndrome and suicidality among survivors of Middle East respiratory syndrome over a 2-year follow-up period - Ahn SH, Kim JL, Kim JR, Lee SH, Yim HW, Jeong H, Chae JH, Park HY, Lee JJ, Lee H.
Suicide is an important public health issue during the current pandemic of emerging infectious diseases (EIDs). In EIDs, various symptoms persist even after recovery, and chronic fatigue is among those that are commonly reported. The aim of this study was ... (Source: SafetyLit)
Source: SafetyLit - March 4, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Epidemiology, prevention, and sequelae of drowning - McCallin TE, Morgan M, Hart MLI, Yusuf S.
Drowning is defined as "the process of experiencing respiratory impairment from submersion/immersion in liquid." (1) A drowning or submersion event is described either as fatal or nonfatal with or without morbidity. Older terms such as near, dry, wet, acti... (Source: SafetyLit)
Source: SafetyLit - March 4, 2021 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Luminex Receives FDA Emergency Use Authorization and CE Mark for Expanded NxTAG(R) Respiratory Panel Test Including SARS-CoV-2
Provides labs with high throughput, syndromic respiratory testing capabilities AUSTIN, Texas, March 4, 2021 -- (Healthcare Sales & Marketing Network) -- Luminex Corporation (NASDAQ: LMNX) today announced that it has received Emergency Use Authorization... Diagnostics, FDA, Regulatory Luminex, SARS-CoV-2, COVID-19, NxTAG (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - March 4, 2021 Category: Pharmaceuticals Source Type: news

Rapid point-of-care test for respiratory infections liked by GPs and may reduce antibiotic prescribing
A rapid microbiological point-of-care test to diagnose respiratory infections has proved popular with GPs and could reduce antibiotic prescribing in primary care, according to a National Institute for Health Research funded study by researchers at the Centre for Academic Primary Care, University of Bristol. (Source: University of Bristol news)
Source: University of Bristol news - March 4, 2021 Category: Universities & Medical Training Tags: Health, International, Research; Faculty of Health Sciences, Faculty of Health Sciences, Population Health Sciences; Press Release Source Type: news

Do known drugs help against SARS-coronavirus-2?
(Deutsches Primatenzentrum (DPZ)/German Primate Center) Pancreatitis drug Camostat inhibits new SARS-CoV-2 activators identified in the upper respiratory tract (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 4, 2021 Category: Biology Source Type: news

White House: Next 3 Months'Pivotal' In COVID Fight White House: Next 3 Months'Pivotal' In COVID Fight
The next 3 months in the fight against the coronavirus pandemic are"pivotal," CDC Director Rochelle Walensky, MD, said.WebMD Health News (Source: Medscape Pulmonary Medicine Headlines)
Source: Medscape Pulmonary Medicine Headlines - March 3, 2021 Category: Respiratory Medicine Tags: Infectious Diseases News Source Type: news

Does an Arthritis Drug Help Patients Battling Severe COVID? It Depends on the Study
(Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - March 3, 2021 Category: Respiratory Medicine Tags: Infections, Nursing, Pharmacy, Pulmonology, Research, Rheumatology, News, Source Type: news

Vaping Marijuana May Be Worse For Your Lungs Than Smoking Cigarettes
Researchers found that adolescents who vape cannabis are at greater risk for respiratory symptoms indicative of lung injury than teens who smoke cigarettes or marijuana, or vape nicotine. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - March 3, 2021 Category: Pharmaceuticals Authors: Misha Gajewski, Contributor Tags: Healthcare /healthcare Innovation /innovation Lifestyle /lifestyle Vices /vices Source Type: news

Study Suggests Teens Who Vape Cannabis May Have More Symptoms Of Lung Injury Than Those Who Smoke
Researchers found that adolescents who vape cannabis are at greater risk for respiratory symptoms indicative of lung injury than teens who smoke cigarettes or marijuana, or vape nicotine. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - March 3, 2021 Category: Pharmaceuticals Authors: Misha Gajewski, Contributor Tags: Healthcare /healthcare Innovation /innovation Lifestyle /lifestyle Vices /vices Source Type: news

Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019, Critical care medicine 49(2): e170-e178
Conclusions: Our predefined 33-messenger RNA endotypes classifier recapitulated immune phenotypes in viral sepsis (coronavirus disease 2019) despite its prior training and validation only in bacterial sepsis. Further work should focus on continued validation of the endotypes and their interaction with immunomodulatory therapy. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 3, 2021 Category: Consumer Health News Source Type: news

EARLY RELEASE: First Identified Cases of SARS-CoV-2 Variant P.1 in the United States - Minnesota, January 2021
This report describes the first two U.S. cases of the SARS-CoV-2 variant P.1, which were identified in Minnesota. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - March 3, 2021 Category: American Health Tags: MMWR Morbidity & Mortality Weekly Report SARS (Severe acute respiratory syndrome) COVID-19 Source Type: news

Mozambique: Over 1,300 Recover From Covid-19 in a Day
[AIM] Maputo -- The Mozambican health authorities on Tuesday reported that 1,384 people had made a full recovery from the Covid-19 respiratory disease in the previous 24 hours. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - March 3, 2021 Category: African Health Source Type: news

Disentangling the complex bidirectional associations between COVID-19 and psychiatric disorder, Lancet Psychiatry
In The Lancet Psychiatry, Maxime Taquet and colleagues reported that survivors of COVID-19 appear to be at increased risk of psychiatric sequelae, and that a psychiatric diagnosis might be an independent risk factor for COVID-19. We are concerned that several limitations might weaken the bidirectional associations between COVID-19 and psychiatric disorder. First, evidence suggests that the medical isolation of hospitalised patients might have a negative effect on their mental wellbeing and behaviour, with higher levels of depression and anxiety among isolated patients.Therefore, the psychiatric sequelae of COVID-19 might r...
Source: Current Awareness Service for Health (CASH) - March 3, 2021 Category: Consumer Health News Source Type: news

SARS-CoV-2 immunization passports: A ticket to normal life?
(Canadian Medical Association Journal) Proof of immunization against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may soon be required in many parts of the globe. The authors discuss how immunization passports could work, what Canada needs to do, and potential barriers and limitations in a CMAJ (Canadian Medical Association Journal) commentary www.cmaj.ca/lookup/doi/10.1503/cmaj.210244. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 3, 2021 Category: International Medicine & Public Health Source Type: news

Study contributes to evidence for potential association between blood group a and COVID-19
(American Society of Hematology) As researchers around the world work to identify and address risk factors for severe COVID-19, there is additional evidence that certain blood types could be associated with greater risk of contracting the disease. A new Blood Advances study details one of the first laboratory studies to suggest that SARS-CoV-2, the virus that causes COVID-19, is particularly attracted to the blood group A antigen found on respiratory cells. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 3, 2021 Category: Infectious Diseases Source Type: news

Rapid test for respiratory infections liked by GPs and may reduce antibiotic prescribing
(University of Bristol) A rapid microbiological point-of-care test to diagnose respiratory infections has proved popular with GPs and could reduce antibiotic prescribing in primary care, according to a National Institute for Health Research funded study by researchers at the Centre for Academic Primary Care, University of Bristol. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 3, 2021 Category: International Medicine & Public Health Source Type: news

​IL - 6 Receptor Antagonists Benefit Critically Ill With COVID - 19 ​
Improved outcomes, including more organ support - free days, reduced mortality, seen with tocilizumab, sarilumab (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - March 2, 2021 Category: Respiratory Medicine Tags: Infections, Pharmacy, Pulmonology, Critical Care, Journal, Source Type: news

Face Masks Won ’ t Impede Your Breathing, Study Confirms
(Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - March 2, 2021 Category: Respiratory Medicine Tags: Infections, Pulmonology, Preventive Medicine, News, Source Type: news

Response to One Dose of COVID-19 Vaccine Strong for Previously Infected
TUESDAY, March 2, 2021 -- Individuals with previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection generate strong responses to one dose of the BNT162b2 vaccine, according to two research letters published online Feb. 25 in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 2, 2021 Category: Pharmaceuticals Source Type: news

Can AI predict COVID-19 hot spots from chest CT reports?
Machine learning-based analysis of chest CT reports for respiratory illnes...Read more on AuntMinnie.comRelated Reading: COVID-19 takes toll on well-being of radiology staff COVID-19 vaccine affects imaging results, researchers warn COVID-19 patients may be vulnerable to leukoencephalopathy AI can predict need for steroid treatments in COVID-19 patients New COVID-19 AI models offer promising results (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 2, 2021 Category: Radiology Source Type: news

Face Masks Won't Impede Your Breathing, Study Confirms
Title: Face Masks Won't Impede Your Breathing, Study ConfirmsCategory: Health NewsCreated: 3/2/2021 12:00:00 AMLast Editorial Review: 3/2/2021 12:00:00 AM (Source: MedicineNet Asthma General)
Source: MedicineNet Asthma General - March 2, 2021 Category: Respiratory Medicine Source Type: news

Researchers find effective combination of therapies for managing mitochondrial disease
(Children's Hospital of Philadelphia) Researchers have demonstrated how one combination of therapies may be beneficial for patients with mitochondrial respiratory chain disorders. This preclinical research paves the way to develop more tailored treatment options for patients with inherited mitochondrial disease and acquired energy disorders. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 2, 2021 Category: International Medicine & Public Health Source Type: news

Assessment of respiratory function in infants, young children wearing face masks during COVID-19 pandemic
(JAMA Network) Wearing surgical face masks for 30 minutes was not associated with changes in respiratory parameters or clinical signs of respiratory distress in this study of 47 infants and young children in Italy. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - March 2, 2021 Category: International Medicine & Public Health Source Type: news

New cell line could lead to more reliable vaccine development to fight costly pig virus
(Iowa State University) The production of autogenous vaccines to fight individual strains of the virus that causes porcine reproductive and respiratory syndrome depends on the ability of scientists to isolate the virus, but sometimes that's a tricky process. A new study from an Iowa State University researcher shows that a new cell line may offer a better alternative to the cell line most commonly used to isolate the PRRS virus. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 2, 2021 Category: Biology Source Type: news

< a href= " /news-events/nih-research-matters/antibody-treatment-mers-coronavirus-safe-people " > Antibody treatment for MERS coronavirus safe in people < /a >
A combination of two monoclonal antibodies prevented and effectively treated Middle East Respiratory Syndrome (MERS) in mice. (Source: NIH Research Matters)
Source: NIH Research Matters - March 2, 2021 Category: Research Source Type: news

COVID - 19 Outcomes No Worse for People With Asthma
Patients with asthma may have a lower risk for becoming infected (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - March 1, 2021 Category: Respiratory Medicine Tags: Family Medicine, Geriatrics, Gynecology, Infections, Internal Medicine, Critical Care, Emergency Medicine, Nursing, Pulmonology, Journal, Source Type: news

High Dose of Vitamin D Does Not Cut COVID - 19 Hospital Stay
No significant differences seen for other outcomes among patients hospitalized with moderate - to - severe disease (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - March 1, 2021 Category: Respiratory Medicine Tags: Family Medicine, Geriatrics, Infections, Internal Medicine, Critical Care, Emergency Medicine, Pharmacy, Pulmonology, Journal, Source Type: news

Mozambique: Health Ministry Needs Ten Days to Prepare Vaccination
[AIM] Maputo -- The Mozambican Ministry of Health needs a further ten days to complete its preparations for vaccinating health professionals against the Covid-19 respiratory disease, according to Health Minister Armindo Tiago. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - March 1, 2021 Category: African Health Source Type: news

How Do You Know if You Have a Sinus Infection (Sinusitis) or COVID-19 Coronavirus?
Title: How Do You Know if You Have a Sinus Infection (Sinusitis) or COVID-19 Coronavirus?Category: Diseases and ConditionsCreated: 3/1/2021 12:00:00 AMLast Editorial Review: 3/1/2021 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - March 1, 2021 Category: Respiratory Medicine Source Type: news

Could our immune system be why COVID-19 is so deadly?
(Earlham Institute) Respiratory viruses such as SARS-CoV-2 (causing COVID-19) can often catalyse an overactive immune response that leads to a life-threatening cycle, known as a cytokine storm. Analysing cytokine responses from patients infected with SARS-CoV-2 and similar common respiratory viruses has unearthed glaringly important differences in how SARS-CoV-2 affects cytokines compared to other common respiratory viruses. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 1, 2021 Category: Infectious Diseases Source Type: news

Johnson & Johnson Announces U.S. CDC Advisory Committee Recommends First Single-Shot COVID-19 Vaccine for Adults 18 and Older in U.S.
NEW BRUNSWICK, N.J., February 28, 2021 – Johnson & Johnson (NYSE: JNJ) (the Company) today announced that the U.S. Centers for Disease Control and Prevention’s (CDC) Advisory Committee on Immunization Practices (ACIP) has recommended the first single-shot COVID-19 vaccine, developed by the Janssen Pharmaceutical Companies of Johnson & Johnson, for individuals 18 years of age and older under the Emergency Use Authorization (EUA) issued by the U.S. Food and Drug Administration (FDA). “For more than 130 years, Johnson & Johnson has come to the aid of people during times of crisis, and we believe ...
Source: Johnson and Johnson - February 28, 2021 Category: Pharmaceuticals Source Type: news

Johnson & Johnson COVID-19 Vaccine Authorized by U.S. FDA For Emergency Use
NEW BRUNSWICK, N.J., February 27, 2021 – Johnson & Johnson (NYSE: JNJ) (the Company) today announced that the U.S. Food and Drug Administration (FDA) has issued Emergency Use Authorization (EUA) for its single-dose COVID-19 vaccine, developed by the Janssen Pharmaceutical Companies of Johnson & Johnson, to prevent COVID-19 in individuals 18 years of age and older. This decision was based on the totality of scientific evidence, including data from the Phase 3 ENSEMBLE study that demonstrated the vaccine was 85 percent effective in preventing severe disease across all regions studied, and showed protection agai...
Source: Johnson and Johnson - February 28, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

FDA issues Emergency Use Authorization for third COVID-19 vaccine
Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for the third vaccine for the prevention of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The EUA allows the Janssen COVID-19 Vaccine to be distributed in the U.S for use in individuals 18 years of age and older. (Source: World Pharma News)
Source: World Pharma News - February 27, 2021 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

Physician ’ s Briefing Weekly Coronavirus Roundup
(Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - February 27, 2021 Category: Respiratory Medicine Tags: Family Medicine, Geriatrics, Gynecology, Infections, Internal Medicine, Critical Care, Emergency Medicine, Nursing, Pathology, Pediatrics, Pharmacy, Pulmonology, Radiology, Institutional, Source Type: news

More Frequent Disinfectant Use Tied to Uncontrolled Asthma
Findings seen in a survey of U.S. adults with asthma during the COVID - 19 pandemic (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - February 26, 2021 Category: Respiratory Medicine Tags: Family Medicine, Infections, Internal Medicine, Allergy, Pulmonology, Journal, Source Type: news

Possible SARS-CoV-2 Reinfection Described at Skilled Nursing Facility
FRIDAY, Feb. 26, 2021 -- Possible reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed at a skilled nursing facility (SNF) in Kentucky, according to research published in the Feb. 26 issue of the U.S.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 26, 2021 Category: Pharmaceuticals Source Type: news

Roche receives positive CHMP opinion for Evrysdi, the first and only at home spinal muscular atrophy (SMA) treatment with proven efficacy in adults, children and infants two months and older
Basel, 26 February 2021 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of Evrysdi ™ (risdiplam) for the treatment of 5q spinal muscular atrophy (SMA) in patients 2 months of age and older, with a clinical diagnosis of SMA Type 1, Type 2 or Type 3 or with one to four SMN2 copies. SMA is a leading genetic cause of death in infants and 5q SMA is the most common form of the disease . SMA causes progressive muscle weakness and atrophy, and significant unmet need remains, particularly in adults ...
Source: Roche Media News - February 26, 2021 Category: Pharmaceuticals Source Type: news

Roche receives positive CHMP opinion for Evrysdi, the first and only at home spinal muscular atrophy (SMA) treatment with proven efficacy in adults, children and infants two months and older
Basel, 26 February 2021 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) has recommended the approval of Evrysdi ™ (risdiplam) for the treatment of 5q spinal muscular atrophy (SMA) in patients 2 months of age and older, with a clinical diagnosis of SMA Type 1, Type 2 or Type 3 or with one to four SMN2 copies. SMA is a leading genetic cause of death in infants and 5q SMA is the most common form of the disease . SMA causes progressive muscle weakness and atrophy, and significant unmet need remains, particularly in adults ...
Source: Roche Investor Update - February 26, 2021 Category: Pharmaceuticals Source Type: news

Menthols Lured 10 Million Americans to Smoking Since 1980: Study
Title: Menthols Lured 10 Million Americans to Smoking Since 1980: StudyCategory: Health NewsCreated: 2/26/2021 12:00:00 AMLast Editorial Review: 2/26/2021 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - February 26, 2021 Category: Respiratory Medicine Source Type: news

Missed Visits During Pandemic Cause'Detrimental Ripple Effects'Missed Visits During Pandemic Cause'Detrimental Ripple Effects '
Patients with chronic diseases are more likely to have postponed care because of COVID-19 precautions, a survey finds, and physicians are seeing the consequences.Medscape Medical News (Source: Medscape Pulmonary Medicine Headlines)
Source: Medscape Pulmonary Medicine Headlines - February 26, 2021 Category: Respiratory Medicine Tags: Family Medicine/Primary Care News Source Type: news

Risk Reduced for Positive NAAT Result With SARS-CoV-2 Antibodies
THURSDAY, Feb. 25, 2021 -- Having severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies is associated with a reduced risk for future infection, according to a study published online Feb. 24 in JAMA Internal Medicine. Raymond A.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 25, 2021 Category: Pharmaceuticals Source Type: news

My Family Is Still Being Careful About COVID-19. Why Does It Feel Like We ’re the Only Ones?
Welcome to COVID Questions, TIME’s advice column. We’re trying to make living through the pandemic a little easier, with expert-backed answers to your toughest coronavirus-related dilemmas. While we can’t and don’t offer medical advice—those questions should go to your doctor—we hope this column will help you sort through this stressful and confusing time. Got a question? Write to us at covidquestions@time.com. Today, K.K. in California asks: My son is almost two, and he was born prematurely at 33 weeks. We don’t ever want to see him in the hospital again, and especially not becaus...
Source: TIME: Health - February 25, 2021 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID Questions COVID-19 Source Type: news

CMS: Medicare Program: Hospital Outpatient Prospective Payment and Ambulatory Surgical Center Payment Systems and Quality Reporting Programs; New Categories for Hospital Outpatient Department Prior Authorization Process; Clinical Laboratory Fee Schedule: Laboratory Date of Service Policy; Overall Hospital Quality Star Rating Methodology; Physician-Owned Hospitals; Notice of Closure of Two Teaching Hospitals and Opportunity To Apply for Available Slots; Radiation Oncology Model; and Reporting Requirements for Hospitals and Critical Access Hospitals (CAHs) to Report COVID-19 Therapeutic Inventory and Usage and To Report Acute Respiratory Illness During the Public Health Emergency (PHE) for Coronavirus Disease 2019 (COVID-19); Correction
Notice from the Centers for Medicare and Medicaid Services (CMS) making technical and typographical corrections to theDecember 29, 2020, final rule. This correction is effective February 25, 2021. (Source: Federal Register updates via the Rural Assistance Center)
Source: Federal Register updates via the Rural Assistance Center - February 25, 2021 Category: Rural Health Source Type: news

Diversity among study participants credited with identifying gene linked to asthma
(Henry Ford Health System) Researchers at Henry Ford Health System, as part of a national asthma collaborative, have identified a gene variant associated with childhood asthma that underscores the importance of including diverse patient populations in research studies.The study is published in the print version of the American Journal of Respiratory and Critical Care Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Model-informed COVID-19 vaccine prioritization strategies by age and serostatus
Limited initial supply of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine raises the question of how to prioritize available doses. We used a mathematical model to compare five age-stratified prioritization strategies. A highly effective transmission-blocking vaccine prioritized to adults ages 20 to 49 years minimized cumulative incidence, but mortality and years of life lost were minimized in most scenarios when the vaccine was prioritized to adults greater than 60 years old. Use of individual-level serological tests to redirect doses to seronegative individuals improved the marginal impact of each do...
Source: ScienceNOW - February 25, 2021 Category: Science Authors: Bubar, K. M., Reinholt, K., Kissler, S. M., Lipsitch, M., Cobey, S., Grad, Y. H., Larremore, D. B. Tags: Epidemiology r-articles Source Type: news

Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins interact with the eukaryotic translation machinery, and inhibitors of translation have potent antiviral effects. We found that the drug plitidepsin (aplidin), which has limited clinical approval, possesses antiviral activity (90% inhibitory concentration = 0.88 nM) that is more potent than remdesivir against SARS-CoV-2 in vitro by a factor of 27.5, with limited toxicity in cell culture. Through the use of a drug-resistant mutant, we show that the antiviral activity of plitidepsin against SARS-CoV-2 is mediated through inhibition of the known target...
Source: ScienceNOW - February 25, 2021 Category: Science Authors: White, K. M., Rosales, R., Yildiz, S., Kehrer, T., Miorin, L., Moreno, E., Jangra, S., Uccellini, M. B., Rathnasinghe, R., Coughlan, L., Martinez-Romero, C., Batra, J., Rojc, A., Bouhaddou, M., Fabius, J. M., Obernier, K., Dejosez, M., Guillen, M. J., Los Tags: Medicine, Diseases, Virology r-articles Source Type: news

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity
Immunoglobulin G (IgG) antibodies are crucial for protection against invading pathogens. A highly conserved N-linked glycan within the IgG-Fc tail, which is essential for IgG function, shows variable composition in humans. Afucosylated IgG variants are already used in anticancer therapeutic antibodies for their increased activity through Fc receptors (FcRIIIa). Here, we report that afucosylated IgG (approximately 6% of total IgG in humans) are specifically formed against enveloped viruses but generally not against other antigens. This mediates stronger FcRIIIa responses but also amplifies brewing cytokine storms and immune...
Source: ScienceNOW - February 25, 2021 Category: Science Authors: Larsen, M. D., de Graaf, E. L., Sonneveld, M. E., Plomp, H. R., Nouta, J., Hoepel, W., Chen, H.-J., Linty, F., Visser, R., Brinkhaus, M., Sustic, T., de Taeye, S. W., Bentlage, A. E. H., Toivonen, S., Koeleman, C. A. M., Sainio, S., Kootstra, N. A., Brouw Tags: Immunology, Microbiology r-articles Source Type: news