IIG seminar “ Myeloid-derived IL-33 intersects with neuronal immunity ”
This seminar will be given by Dr. Herbert who has made important contributions towards understanding mechanisms controlling development of alternatively activated macrophages and Type 2 inflammation within the respiratory and gastrointestinal tract. His recent findings reveal a previously undescribed mechanism of intercellular cross-talk wherein “ itch ” neuron activation reshapes myeloid cytokine expression patterns to alter skin composition for cutaneous immunity against invasive pathogens.Air date: 5/15/2024 4:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - April 16, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS- George Khoury Lecture: Coronavirus Activation and Antagonism of Interferon Signaling Pathways: from MHV to SARS-CoV-2
Coronavirus interactions with the interferon signaling response are crucial for antiviral defense especially at the early stages of infection. Murine coronavirus, MHV, has taught us a lot about the basic biology of this family of viruses as well as antagonism of innate immune response, a hallmark of coronavirus infection. Building on our MHV data, we have more recently worked with human coronaviruses. We have optimized methods for comparing human coronaviruses in a primary nasal cell air liquid interface (ALI) culture system, which models the initial site of respiratory virus infection. Common cold coronaviruses as well as...
Source: Videocast - All Events - March 6, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH FDA COVID-19 SIG Lecture Series- Professor Wendy Barclay
Dr. Barclay joined Imperial College in May 2007, moving with her research group from the University of Reading where she had previously been based since 1995. She had graduated in Natural Sciences from Cambridge University and had undertaken my PhD at the Common Cold Unit, Salisbury under the joint supervision of Dr David Tyrrell and Dr Fred Brown, studying the human immune response to rhinovirus. Dr. Barclay acquired molecular virology skills as a postdoctoral fellow first in the laboratories of Professor Jeff Almond at Reading and then working with Dr Peter Palese at the Mount Sinai School of Medicine, New York.Dr. Barcl...
Source: Videocast - All Events - December 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS- George Khoury Lecture: Coronavirus Activation and Antagonism of Innate Immune Pathways
Our lab studies murine and human coronavirus pathogenesis, including MHV, MERS-CoV and SARS-CoV. We use MHV infection of mice as a model system for the study of:acute viral encephalitischronic demyelinating diseases such as Multiple Sclerosisvirus-induced hepatitissevere acute respiratory diseases.We have the important tools of a well-developed animal model system and reverse genetic systems with which to manipulate the viral genome. We also investigate pathogenesis of human coronaviruses both the lethal MERS-CoV and SARS-CoV-2 as well as the common cold viruses OC43 and 229E and NL63. We are investigating these both in ep...
Source: Videocast - All Events - October 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH – FDA COVID SIG Lecture: Viral RNA Sensors in Human Immunity to SARS-CoV-2
This is an NIH – FDA COVID-19 SIG seminar talk. Helen Su, M.D., Ph.D., is chief of the Human Immunological Diseases Section in NIAID. LECTURE SUMMARY: Impaired type I IFN responses can lead to life-threatening COVID-19. Previous reports have established that the endosomal viral RNA sensors TLR3 and TLR7 initiate protective type I IFN responses during SARS-CoV-2 infections in humans. However, the role of the cytosolic RIG-I-like receptors (RLRs), which are more broadly expressed, has been less well studied. We investigated rare variants in the genes encoding MDA5, RIG-I, and their downstream signaling adaptor MAVS,from a ...
Source: Videocast - All Events - June 21, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Biomedical Engineering Scientific Interest Group: Engineering mucus and innate lung defense
Gregg Duncan earned his Ph.D. in chemical engineering under the guidance of Michael Bevan at Johns Hopkins University in 2014. He then completed his postdoctoral training at Johns Hopkins School of Medicine in the Center for Nanomedicine directed by Justin Hanes. Dr. Duncan is currently an Assistant Professor in the Fischell Department of Bioengineering at the University of Maryland. Dr. Duncan leads the Respiratory Nano Bioengineering (RnB) lab, which aims to understand the airway microenvironment in health and disease to engineer new therapeutic strategies for obstructive lung diseases such as asthma, chronic obstructive...
Source: Videocast - All Events - May 23, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Tackling Brain and Muscle Dysfunction in ARDS Survivors
Acute respiratory distress syndrome (ARDS) is a serious lung condition that is defined by life-threatening low blood oxygen and often causes dysfunction in multiple organs. People who survive ARDS often face significant cognitive impairment and limited body mobility, which reduces their quality of life. The molecular mechanisms underlying these long-term health issues in ARDS survivors remain elusive. Emerging data suggest that neuroinflammation and muscle wasting contribute to brain and muscle dysfunction in ARDS survivors, but researchers need to better understand the pathophysiology of this area.NHLBI will host a virtua...
Source: Videocast - All Events - April 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Tackling Brain and Muscle Dysfunction in ARDS Survivors
Acute respiratory distress syndrome (ARDS) is a serious lung condition that is defined by life-threatening low blood oxygen and often causes dysfunction in multiple organs. People who survive ARDS often face significant cognitive impairment and limited body mobility, which reduces their quality of life. The molecular mechanisms underlying these long-term health issues in ARDS survivors remain elusive. Emerging data suggest that neuroinflammation and muscle wasting contribute to brain and muscle dysfunction in ARDS survivors, but researchers need to better understand the pathophysiology of this area.NHLBI will host a virtua...
Source: Videocast - All Events - April 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series: Developing novel immunotherapy strategies for HPV-associated respiratory papillomatosis
Recurrent respiratory papillomatosis (RRP) is a rare disorder that manifests as progressively growing aerodigestive tract papillomas that cause profound voice disturbance and airway obstruction. The disorder is caused by chronic infection with HPV type 6 or 11. One research interest of the Allen lab is to develop and study novel, rationally designed therapeutic approaches for RRP. In this lecture, Dr. Allen will highlight newly identified mechanisms of immune escape utilized by HPV6 or 11 to escape innate and adaptive immunity and discuss the results of prospective immunotherapy clinical trials conducted at the NIH Clinica...
Source: Videocast - All Events - March 7, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH – FDA COVID SIG Lecture with Helen Su, M.D., Ph.D.
Helen Su, M.D., Ph.D., is chief of the Human Immunological Diseases Section in NIAID. The Human Immunological Diseases Section (HIDS) carries out research to understand the molecular mechanisms regulating the human immune system and how their derangements cause disease. They study patients with poorly characterized, inherited immunodeficiencies and autoimmune diseases, often lacking molecular diagnoses.
Major Areas of Research: Defining the molecular mechanisms of new inherited human immunological diseases; Understanding DOCK8 function in health and human disease; Elucidating innate immunoregulatory mechanisms for contro...
Source: Videocast - All Events - February 10, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH – FDA COVID SIG Lecture with Valentina Parma, Ph.D.
Valentina Parma, Ph.D., is Assistant Director at Monell Chemical Senses Center, Philadelphia. From the speaker: " I am a psychologist interested in human olfaction across the lifespan. Both my basic and translational work aims at finding ways to use smell as an opportunity to improve health. I use behavioral and physiological methods to understand how odors influence typical and atypical behavior. Recently, I have been chairing the Global Consortium for Chemosensory Research (GCCR) to understand how smell, taste and chemesthesis are affected by COVID-19 and other respiratory disorders, I have co-developed smell tests to fa...
Source: Videocast - All Events - February 10, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Highlights of Pandemic Related Successes in Tribal Communities, a webinar co-sponsored by the NIH RECOVER, NIH CEAL, and the NIH Tribal Health Research Office
The NIH Researching COVID to Enhance Recovery Initiative, also called NIH RECOVER, in partnership with the Community Engagement Alliance (CEAL) and the Tribal Health Research Office (THRO) invites research teams to attend the Highlights of Pandemic Related Successes in Tribal Communities Webinar on Wednesday, December 7, 2022, from 2PM – 4PM EST. This exciting webinar, tailored specifically for research team members across RECOVER, CEAL and NIH, will spotlight successful approaches used during the COVID-19 pandemic to engage members of Tribal Communities. Panelists will share how they met the needs and priorities of thes...
Source: Videocast - All Events - November 28, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Interpreting the Evolution of SARS-CoV-2
COVID-19 SIG
SARS-CoV-2 has undergone rapid antigenic evolution over the last few years. I will discuss how the patterns of SARS-CoV-2 evolution compare to other human respiratory viruses. I will also discuss how high-throughput deep mutational scanning experiments can help us interpret the ongoing evolution and get some idea of what might come next Presentation objectives: Explain the different ways that human respiratory viruses evolve in response to immune pressure. Explain how deep mutational scanning can be used to understand the effects of viral mutations. Explain how experimental data can be used to interpret and to...
Source: Videocast - All Events - November 9, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
COVID Lecture: SARS-CoV-2: What We Have Learned So Far
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for COVID-19, continues to spread around the world and has caused millions of deaths to date. In an effort to develop therapeutics and preventive measures, we are performing numerous research projects with this virus and its variants. In this presentation, I will discuss our findings regarding animal models and their value as tools for evaluating countermeasures against SARS-CoV-2.For more information go tohttps://www.niaid.nih.gov/research/covid-19-sig-lecture-seriesAir date: 5/26/2022 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 23, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Acute Severe COVID-19 and Multisystem Inflammatory Syndrome in U.S. Children and Adolescents
Speaker Adrienne G. Randolph is Senior Associate, Critical Care Medicine at Boston Children's Hospital and Professor of Anaesthesia and Pediatrics, Harvard Medical School. The Randolph Lab studies the immunobiology of critical illness in children with a focus on life-threatening and fatal infections and acute lung injury. Her long-term goal is to identify new diagnostic tests and therapies that could restore health more rapidly and decrease morbidity and mortality. Her laboratory focuses on clinical-translational research in the areas of the immune response of pediatric patients with acute respiratory distress syndrome and...
Source: Videocast - All Events - September 23, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
