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Effect of Heat Moisture Exchanger on Aerosol Drug Delivery and Airway Resistance in Simulated Ventilator-Dependent Adults Using Jet and Mesh Nebulizers
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - August 22, 2017 Category: Respiratory Medicine Authors: Arzu Ari Truong Dang Fahad H. Al Enazi Mohammed M. Alqahtani Abdulrahman Alkhathami Rowaida Qoutah Ahmad S. Almamary James B. Fink Source Type: research

Identification of mycobacterial bacterioferritin B for immune screening of tuberculosis and latent tuberculosis infection
It remains necessary and urgent to search for novel mycobacterial antigens to increase the sensitivity and specificity for tuberculosis (TB) diagnosis and latent TB infection (LTBI) screening. Antigens capable of inducing strong immune responses during Mycobacterium tuberculosis (M.tb) infection would be good candidates. (Source: Tuberculosis)
Source: Tuberculosis - August 22, 2017 Category: Respiratory Medicine Authors: Xinyu Yang, Jia-bao Wu, Ying Liu, Yanqing Xiong, Ping Ji, Shu-jun Wang, Yingying Chen, Guo-ping Zhao, Shui-hua Lu, Ying Wang Source Type: research

A novel approach based on low ‐field NMR for the detection of the pathological components of sputum in cystic fibrosis patients
PurposeDevelopment of a reliable, simple method to monitor lung condition in cystic fibrosis (CF) patients. Lung functionality assessment in CF patients is relevant, as most of them still die of respiratory failure. In lung mucus (sputum) of CF patients, components such as proteins, biopolymers, DNA, bacteria, and mucin are pathologically increased. As lung functionality is related to the amount of the pathological components in the sputum, their determination can help clinicians in monitoring lung condition and planning therapy. MethodsLow‐field NMR was used to evaluate the variation of the relaxation time (T2m) of the ...
Source: Magnetic Resonance in Medicine - August 22, 2017 Category: Radiology Authors: Michela Abrami, Fiorentina Ascenzioni, Enea Gino Di Domenico, Massimo Maschio, Alessandro Ventura, Marco Confalonieri, Sante Di Gioia, Massimo Conese, Barbara Dapas, Gabriele Grassi, Mario Grassi Tags: Full Paper Source Type: research

Pathology of infectious diseases of the lower respiratory system
Specific texts on infectious diseases and those in textbooks on pulmonary pathology commonly approach the subject of infection in the lung from an etiological microbiological perspective, listing infectious agents by taxonomy followed by associated pathology. However, in practice one is faced with a specimen in which a reaction pattern is seen (usually of inflammatory nature) which may be indicative of a specific type of infection. In these circumstances an approach leading from reaction pattern to specific microbiological diagnosis is required. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - August 22, 2017 Category: Pathology Authors: Michael A. den Bakker Tags: Mini-symposium: pathology of infectious diseases – I Source Type: research

Pelvic Abscess Secondary to Mycoplasma hominis following Vaginal Laceration
Mycoplasma hominis frequently colonizes the urogenital and respiratory tracts of healthy individuals. It has also been associated with genitourinary tract and extra-genital syndromes. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - August 22, 2017 Category: OBGYN Authors: Vini Vijayan, Gail L. Woods, Dale R. Donnell, Jos é R. Romero Source Type: research

Persistent respiratory effort after adenotonsillectomy in children with sleep ‐disordered breathing
ConclusionAdenotonsillectomy significantly reduced AHI. However, persistent RERA were apparent in a significant proportion of children, and this was reflected by the remaining abnormal MMas pattern. Follow‐up of children after AT can be recommended and readily achieved by monitoring MMas to identify persistent RE. Level of Evidence4. Laryngoscope, 2017 (Source: The Laryngoscope)
Source: The Laryngoscope - August 22, 2017 Category: ENT & OMF Authors: Jean ‐Benoît Martinot, N. Nam Le‐Dong, Stéphane Denison, Hervé Jean‐Pierre Guénard, Jean‐Christian Borel, Philip E. Silkoff, Jean‐Louis Pepin, David Gozal Tags: Sleep Medicine Source Type: research

Psychiatric Emergencies for Clinicians: Emergency Department Management of Cocaine-Related Presentations
A 32-year-old man presented via ambulance to an inner-city emergency department (ED) with chest pain and anxiety. At triage, his blood pressure was 182/100  mm Hg, heart rate was 120 beats/min, respiratory rate was 22 breaths/min, oxygen saturation was 98%, and core temperature was 38.2°C. He denied history of heart disease, hypertension, diabetes, or symptoms of an upper respiratory infection. On examination, he had pressured speech and was visibly  anxious, fidgeting, and constantly looking over his shoulder. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - August 22, 2017 Category: Emergency Medicine Authors: Jagoda Pasic, Paul Zarkowski, Kimberly Nordstrom, Michael P. Wilson Tags: Selected Topics: Psychiatric Emergencies Source Type: research

Cardiac arrest after epidural anesthesia for a esthetic plastic surgery: a case report
Publication date: September–October 2017 Source:Brazilian Journal of Anesthesiology (English Edition), Volume 67, Issue 5 Author(s): Larissa Cardoso Pinheiro, Bruno Mendes Carmona, Mário de Nazareth Chaves Fascio, Iris Santos de Souza, Rui Antonio Aquino de Azevedo, Fabiano Timbó Barbosa Cardiac arrest during neuraxial anesthesia is a serious adverse event, which may lead to significant neurological damage and death if not treated promptly. The associated mechanisms are neglected respiratory failure, extensive sympathetic block, local anaesthetic toxicity, total spinal block, in addition to the growing...
Source: Brazilian Journal of Anesthesiology - August 22, 2017 Category: Anesthesiology Source Type: research

Nocturnal blood pressure fluctuations measured by using pulse transit time in patients with severe obstructive sleep apnea syndrome
ConclusionsThe study reveals that patients with severe OSAS can have periods of BP superposition during night with extremely high SBP and very low oxygen saturation, which may add to a high risk for cardiovascular events during the night. (Source: Sleep and Breathing)
Source: Sleep and Breathing - August 22, 2017 Category: Respiratory Medicine Source Type: research

Mortality and causes of death among women with a history of placental abruption
Abstract IntroductionWomen with a history of placental abruption have an increased later morbidity, but not much is known of the later mortality. Material and MethodsData on women with placental abruption (index cohort) between 1969 and 2005 (n=7805) were collected from the Finnish Hospital Discharge Register and the Finnish Medical Birth Register. A matched reference cohort consisted of women without placental abruption (n=23 523). The causes of death were retrieved from the Cause‐of‐Death Register. Cause‐specific mortality was compared by hazard ratios (HR). Standardized mortality ratios were calculated to compare ...
Source: Acta Obstetricia et Gynecologica Scandinavica - August 21, 2017 Category: OBGYN Authors: Outi Riihim äki, Jorma Paavonen, Tiina Luukkaala, Mika Gissler, Marjo Metsäranta, Sture Andersson, Mika Nuutila, Eero Pukkala, Johanna Melin, Minna Tikkanen Tags: Original Research Article Source Type: research

Efficacy of CO 2 insufflation during thoracoscopic esophagectomy in the left lateral position
AbstractObjectiveThoracoscopic esophagectomy (TE) is widely performed as a minimally invasive technique in the management of esophageal cancer. The aim of this study was to estimate the efficacy of intrathoracic carbon dioxide (CO2) insufflation during TE in the left lateral position.MethodsFrom January 2010 to April 2016, 58 patients with esophageal cancer underwent TE without intrathoracic CO2 insufflation (Group N) and 37 patients with esophageal cancer underwent TE with intrathoracic CO2 insufflation (Group C). The operation results and respiratory parameters during the thoracic procedure were compared in both groups.R...
Source: General Thoracic and Cardiovascular Surgery - August 21, 2017 Category: Cardiovascular & Thoracic Surgery Source Type: research

Maturation Modulates Pharyngeal-Stimulus Provoked Pharyngeal and Respiratory Rhythms in Human Infants
AbstractPharyngeal-provocation induced aerodigestive symptoms in infants remain an enigma. Sources of pharyngeal provocation can be anterograde as with feeding, and retrograde as in gastroesophageal reflux. We determined maturational and dose –response effects of targeted pharyngeal-stimulus on frequency, stability, and magnitude of pharyngeal and respiratory waveforms during multiple pharyngeal swallowing responses in preterm-born infants when they were of full-term postmenstrual age (PMA). Eighteen infants (11 male) were studied long itudinally at 39.8 ± 4.8 weeks PMA (time-1) and 44.1 ±...
Source: Dysphagia - August 21, 2017 Category: Speech-Language Pathology Source Type: research

Erratum to: A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension ™ Delivery Technology in patients with moderate-to-very severe chronic obstructive pulmonary disease
(Source: Respiratory Research)
Source: Respiratory Research - August 21, 2017 Category: Respiratory Medicine Authors: Colin Reisner, Leonardo M. Fabbri, Edward M. Kerwin, Charles Fogarty, Selwyn Spangenthal, Klaus F. Rabe, Gary T. Ferguson, Fernando J. Martinez, James F. Donohue, Patrick Darken, Earl St. Rose, Chad Orevillo, Shannon Strom, Tracy Fischer, Michael Golden a Tags: Erratum Source Type: research

Incidence of Obstructive Sleep Apnea in Elderly Edentulous Patients and the Possible Correlation of Serum Serotonin and Apnea ‐Hypopnea Index
ConclusionOSA was found to be prevalent in edentulous subjects due to pharyngeal collapse and decreased neuromuscular control. An inverse relationship of serum serotonin levels and AHI scores was established. (Source: Journal of Prosthodontics)
Source: Journal of Prosthodontics - August 21, 2017 Category: Dentistry Authors: Arvind Tripathi, Soumyojeet Bagchi, Juhi Singh, Suryakant Tripathi, Narendra Kumar Gupta, Varun Arora Tags: Original Manuscript Source Type: research

Impact of chronic obstructive pulmonary disease severity on diaphragm muscle thickness
Conclusion The static TD measured at RV and at TLC are preserved in COPD. The TF bilaterally was significantly decreased in COPD group and is decreased with increasing severity of COPD. The negative correlation of TF and PaCO2 indicates that the diaphragm dysfunction is the main contributor to neuromuscular respiratory failure in COPD patients. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - August 21, 2017 Category: Respiratory Medicine Source Type: research

Could Eosinophilia predict clinical severity in nasal polyps?
AbstractBackgroundAlthough nasal polyps are one of the most frequent diseases, their etiopathogenesis remains unclear.Since eosinophils are the main inflammatory cells in the substantial proportion of nasal polyp tissues, they are considered potentially responsible for the etiopathogenesis and prognosis of the disease. Aim of this study was  to investigate the relation between mucosal and peripheral eosinophilia and their relation with disease severity in nasal polyps.MethodsThe study included 53 patients with nasal polyps who underwent endoscopic sinus surgery. Preoperative Lund-MacKay computed tomography (CT) scores...
Source: Multidisciplinary Respiratory Medicine - August 21, 2017 Category: Respiratory Medicine Source Type: research

Preoperative Halo-Gravity Traction for Severe Thoracic Kyphoscoliosis Patients from Tibet: Radiographic Correction, Pulmonary Function Improvement, Nursing, and Complications.
This study investigated the outcomes of preoperative HGT as an adjunct treatment for severe thoracic kyphoscoliosis, its role in radiographic correction, and pulmonary function improvement, together with nursing strategy and incidence of complications. MATERIAL AND METHODS Eleven patients with a mean age of 18.8 years were retrospectively reviewed. Inclusion criteria were: patients with severe kyphoscoliosis (coronal Cobb angle and kyphosis angle ≥80°); duration of HGT ≥8 weeks; patients undergoing HGT for at least 12 h per day; traction weight no less than 40% of body weight; and patients not receiving physical ...
Source: Medical Science Monitor - August 20, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Effectiveness of 23-valent pneumococcal polysaccharide vaccine and seasonal influenza vaccine for pneumonia among the elderly - Selection of controls in a case-control study.
Abstract We conducted a case-control study to elucidate associations between pneumonia in elderly individuals and 23-valent pneumococcal polysaccharide vaccine (PPSV23) and seasonal influenza vaccine (influenza vaccine). Here, we examined selection of controls in our study using an analytic epidemiology approach. The study period was from October 1, 2009 through September 30, 2014. Cases comprised ≥65-year-old patients newly diagnosed with pneumonia. For every case with pneumonia, two patients with other diseases (one respiratory medicine, one non-respiratory medicine) who were sex-, age-, visit date- and visit...
Source: Vaccine - August 20, 2017 Category: Allergy & Immunology Authors: Kondo K, Suzuki K, Washio M, Ohfuji S, Fukushima W, Maeda A, Hirota Y, Study Group for Pneumonia in the Elderly Individuals Tags: Vaccine Source Type: research

Estimating influenza disease burden among pregnant women: Application of self-control method.
Abstract To evaluate influenza disease burden among pregnant women, an epidemiological study using the self-control method was conducted. Study subjects were 12,838 pregnant women who visited collaborating maternity hospitals and clinics in Osaka Prefecture, Japan, before the 2013/14 influenza season. As a study outcome, hospitalization due to respiratory illnesses between the 2010/11 and 2013/14 seasons was collected from each study subject through a baseline survey at the time of recruitment and a second survey after the 2013/14 season. The hospitalization rates during pregnancy and non-pregnancy periods was cal...
Source: Vaccine - August 20, 2017 Category: Allergy & Immunology Authors: Ohfuji S, Deguchi M, Tachibana D, Koyama M, Takagi T, Yoshioka T, Urae A, Fukushima W, Hirota Y, Osaka Pregnant Women Influenza Study Group Tags: Vaccine Source Type: research

Effects of maternal high-fat diet and sedentary lifestyle on susceptibility of adult offspring to ozone exposure in rats.
Authors: Gordon CJ, Phillips PM, Johnstone AFM, Schmid J, Schladweiler MC, Ledbetter A, Snow SJ, Kodavanti UP Abstract Epidemiological and experimental data suggest that obesity exacerbates the health effects of air pollutants such as ozone (O3). Maternal inactivity and calorically rich diets lead to offspring that show signs of obesity. Exacerbated O3 susceptibility of offspring could thus be manifested by maternal obesity. Thirty-day-old female Long-Evans rats were fed a control (CD) or high-fat (HF) (60% calories) diet for 6 wks and then bred. GD1 rats were then housed with a running wheel (RW) or without a whee...
Source: Inhalation Toxicology - August 20, 2017 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Asthma treatment and outcomes for children in the emergency department and hospital.
Authors: Drewek R, Mirea L, Touresian P, Adelson PD Abstract OBJECTIVE: To describe and compare the treatment of acute asthma exacerbations in children seen in the emergency department (ED) and admitted to acute care floor in the hospital or intensive care unit (ICU). METHODS: Retrospective chart review of visits for acute exacerbation of asthma treated at Phoenix Children's Hospital between January 1, 2014 and December 31, 2016. RESULTS: A total of 287 asthma exacerbation cases were identified including 106 (37%) ED visits, 134 (47%) hospital floor and 47 (16%) ICU admissions. History of a previous ED visi...
Source: Journal of Asthma - August 20, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Extracorporeal membrane oxygenation for acute respiratory distress syndrome in adults: an analysis of differences between survivors and non-survivors.
Abstract OBJECTIVES: Over the last decade, extracorporeal membrane oxygenation (ECMO) has become a promising option for patients with severe acute respiratory distress syndrome (ARDS). In this single-center observational cohort study, data from a patient group with severe ARDS treated with ECMO was analyzed. METHODS: Data from 46 patients [median age 54 years (18 to 72), male: 65.2%] were evaluated retrospectively between January 2009 and September 2015. RESULTS: Diagnosis leading to ARDS was pneumonia in 63.1% of the patients. The median SOFA Score was 13 (10 to 19) and the median LIS was 3.5 (2.67 to 4...
Source: Perfusion - August 20, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Panholzer B, Meckelburg K, Huenges K, Hoffmann G, von der Brelie M, Haake N, Pilarczyk K, Cremer J, Haneya A Tags: Perfusion Source Type: research

The need for systematic diagnosis of exercise-induced respiratory syndromes: the example of swimming-induced pulmonary edema.
Authors: Nikolaidis PT, Knechtle B PMID: 28820003 [PubMed - as supplied by publisher] (Source: The Physician and Sportsmedicine Online)
Source: The Physician and Sportsmedicine Online - August 20, 2017 Category: Sports Medicine Tags: Phys Sportsmed Source Type: research

Differential effect of cigarette smoke exposure on exhaled nitric oxide and blood eosinophils in healthy and asthmatic individuals
Background: Tobacco smoking affects both the fraction of exhaled nitric oxide (FeNO) and blood eosinophil (B-Eos) count, two clinically useful biomarkers in respiratory disease that represent local and systemic type-2 inflammation, respectively. Objective: We aimed to study the influence of objectively measured smoke exposure on FeNO and B-Eos in a large population of subjects with and without asthma. Methods: We utilized the US National Health and Nutrition Examination Surveys 2007 –2012 and included 10 669 subjects aged 6–80 years: 9869 controls and 800 asthmatics. Controls were defined as having no res...
Source: Journal of Breath Research - August 20, 2017 Category: Respiratory Medicine Authors: Tiago Jacinto, Andrei Malinovschi, Christer Janson, Jo ão Fonseca and Kjell Alving Source Type: research

Normal values of offline exhaled and nasal nitric oxide in healthy children and teens using chemiluminescence
Nitric oxide (NO) can be used to detect respiratory or ciliary diseases. Fractional exhaled nitric oxide (FeNO) measurement can reflect ongoing eosinophilic airway inflammation and has a diagnostic utility as a test for asthma screening and follow-up while nasal nitric oxide (nNO) is a valuable screening tool for the diagnosis of primary ciliary dyskinesia. The possibility of collecting airway gas samples in an offline manner offers the advantage to extend these measures and improve the screening and management of these diseases, but normal values from healthy children and teens remain sparse. Methods . Samples were ...
Source: Journal of Breath Research - August 20, 2017 Category: Respiratory Medicine Authors: A Menou, D Babeanu, H N Paruit, A Ordureau, S Guillard and A Chambellan Source Type: research

Effects of hypnosis on the relative parasympathetic tone assessed by ANI (Analgesia/Nociception Index) in healthy volunteers: a prospective observational study
This study shows that hypnosis induces an increase in the relative parasympat hetic tone assessed by ANI in healthy volunteers, with greater ANI values observed in women. These results suggest that ANI monitoring may provide an objective tool for the measurement of the intensity of the hypnotic process, although this should be confirmed by further studies. (Source: Journal of Clinical Monitoring and Computing)
Source: Journal of Clinical Monitoring and Computing - August 20, 2017 Category: Information Technology Source Type: research

Ovarian cancer recurrence and early detection: may HE4 play a key role in this open challenge? A systematic review of literature
Abstract Despite the improvement in overall survival for ovarian cancer (OC) patients, a fraction of patients with advanced-stage disease fails to respond to primary therapy and relapses in 70% of cases. For this reason, new predictive and monitoring tools are needed to identify OC recurrence and new biomarkers were studied, among which human epididymis 4 (HE4), primarily expressed in the reproductive and respiratory tracts, is one of the most promising, reporting a good sensitivity and specificity in detecting OC, overcoming the traditional role of carbohydrate antigen 125 (CA-125). In this review, we aim to discuss the...
Source: Medical Oncology - August 20, 2017 Category: Cancer & Oncology Source Type: research

Endobronchial ultrasound convex probe for lymphoma, sarcoidosis, lung cancer and other thoracic entities. A case series
Publication date: Available online 19 August 2017 Source:Respiratory Medicine Case Reports Author(s): Paul Zarogoulidis, Haidong Huang, Chong Bai, Christoforos Kosmidis, Georgia Trakada, Lemonia Veletza, Theodora Tsiouda, Nikolaos Mparmpetakis, Dimitrios Paliouras, Evangelia Athanasiou, Dimitris Hatzibougias, Anastasios Kallianos, Nikolaos Panagiotopoulos, Liana Papaemmanouil, Wolfgang Hohenforst-Schmidt Endobronchial ultrasound endoscopy is a state of the art diagnostic endoscopic procedure for the thorax. Firstly it was designed mainly for the staging of lung cancer and of course for the diagnosis of suspicious findings...
Source: Respiratory Medicine Case Reports - August 20, 2017 Category: Respiratory Medicine Source Type: research

Burned patients who die from causes other than the burn affect the model used to predict mortality: a national exploratory study
Conclusion Patients with burns who died with a Baux score <100 were a quarter of all the patients who died. An important finding is that most of these deaths were caused by reasons other than the burn, usually cerebrovascular disease. This may be the explanation why the sensitivity of the Baux score is low, as factors other than age and TBSA % explain the fatal outcome (Source: Burns)
Source: Burns - August 20, 2017 Category: Dermatology Source Type: research

Plasma leptin and reduced FEV1 and FVC in Chronic Spinal Cord Injury
Conclusion Plasma leptin in individuals with chronic SCI is inversely associated with FEV1, and FVC, independently of SCI level and severity and other covariates. This finding suggests that plasma leptin may contribute to reduced pulmonary function in chronic SCI. Level of Evidence Level II (Source: PMandR)
Source: PMandR - August 20, 2017 Category: Rehabilitation Source Type: research

The Impact of Deep Muscle Training on the Quality of Posture and Breathing.
Authors: Szczygieł E, Blaut J, Zielonka-Pycka K, Tomaszewski K, Golec J, Czechowska D, Masłoń A, Golec E Abstract Postural control and breathing are mechanically and neuromuscularly interdependent. Both systems- of spinal stability and respiration- involve the diaphragm, transversus abdominis, intercostal muscles, internal oblique muscles and pelvic floor muscles. The aim of the study was to evaluate the effect of exercises activating deep stabilizer muscles on postural control and quality of breathing movements. Eighteen volunteers (25,7 ± 3,5) were recruited from the general population. All the subjects...
Source: Journal of Motor Behavior - August 19, 2017 Category: Neurology Tags: J Mot Behav Source Type: research

Comparison of Efficacy of Self-Expandable Metallic Stent Placement in the Unresectable Esophageal Cancer Patients.
Authors: Uesato M, Akutsu Y, Murakami K, Muto Y, Kagaya A, Nakano A, Aikawa M, Tamachi T, Arasawa T, Amagai H, Muto Y, Matsubara H Abstract This is a retrospective study to evaluate the prevention of complications of metallic stent placement in patients with unresectable advanced esophageal cancer. A total of 87 patients were treated with 4 types of metal stents in the esophagus over a period of 18 years. Stent placement was technically successful. The most common prior treatment was chemoradiotherapy. There were no significant differences in the rate of patients with no complications among the prior treatments. Ap...
Source: Gastroenterology Research and Practice - August 19, 2017 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Xpert MTB/RIF on Stool Is Useful for the Rapid Diagnosis of Tuberculosis in Young Children With Severe Pulmonary Disease
Conclusions: Stool Xpert can rapidly confirm TB in children who present with radiologic findings suggestive of severe TB. In resource-limited settings where children frequently present with advanced disease, Xpert on stool samples could improve access to rapid diagnostic confirmation and appropriate treatment. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - August 19, 2017 Category: Infectious Diseases Tags: Original Studies Source Type: research

The Nasopharyngeal Microbiota of Children With Respiratory Infections in Botswana
Conclusions: Pneumonia and upper respiratory infection symptoms are associated with distinct nasopharyngeal microbiota biotypes in African children. A lower abundance of the commensal genus Dolosigranulum may contribute to the higher pneumonia risk of HIV-infected children. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - August 19, 2017 Category: Infectious Diseases Tags: Original Studies Source Type: research

Measles Cases in Children Requiring Hospital Access in an Academic Pediatric Hospital in Italy, 2008–2013
Conclusions: Hospitalizations of children with measles continue to occur in European areas where elimination has not been achieved. Children with chronic diseases represent a vulnerable population that is at higher risk of hospitalization. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - August 19, 2017 Category: Infectious Diseases Tags: Original Studies Source Type: research

Respiratory Viral Infections and Coinfections Caused by Human Metapneumovirus in Children With Cancer
No abstract available (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - August 19, 2017 Category: Infectious Diseases Tags: Letters to the Editor Source Type: research

Real-life effectiveness of asthma treatment with a fixed-dose fluticasone/formoterol pressurised metered-dose inhaler – Results from a non-interventional study
Prospective, non-interventional study of fixed-dose inhaled corticosteroid (ICS)/long-acting beta2-agonist (LABA) combination therapy with fluticasone propionate/formoterol fumarate (FP/FORM) across a spectrum of community-based patients with asthma in a real-life setting. (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 19, 2017 Category: Respiratory Medicine Authors: O. Schmidt, W. Petro, G. Hoheisel, F. Kanniess, P. Oepen, B. Langer-Brauburger Source Type: research

Mutation in an exonic splicing enhancer site causing chronic granulomatous disease
Publication date: Available online 18 August 2017 Source:Blood Cells, Molecules, and Diseases Author(s): Martin de Boer, Karin van Leeuwen, Judy Geissler, Bernd H. Belohradsky, Taco W. Kuijpers, Dirk Roos In a male patient suffering from X-linked chronic granulomatous disease (CGD) we found a c.389G>T mutation in exon 5 of the CYBB gene. We have analyzed why 95% of the transcripts of this gene lacked exon 5, leading to a frameshift and premature termination codon. The mutation was located in a region comprising three putative exonic splicing enhancer binding sites, for SRSF1, SRFS2 and SRFS6, according to the ESEfi...
Source: Blood Cells, Molecules, and Diseases - August 19, 2017 Category: Hematology Source Type: research

Risk Factors of Frailty Among Multi-Ethnic Malaysian Older Adults
Conclusion Frailty affected about one tenth of the respondents, but almost two thirds were pre-frail. In addition to gender, other modifiable factors including abdominal obesity and poor physical function were identified as risk factors for frailty and pre-frailty among Malaysian older adults. (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - August 19, 2017 Category: Geriatrics Source Type: research

Experience of Lung Transplantation in Patients with Lymphangioleiomyomatosis at a Brazilian Reference Centre
ConclusionsThis data reinforces the role of LT for LAM patients with end-stage disease. The use of sirolimus seems to be safe before LT and the occurrence of complications after LT, including those LAM-related, should be continuously monitored. (Source: Lung)
Source: Lung - August 19, 2017 Category: Respiratory Medicine Source Type: research

Comparison of two home sleep testing devices with different strategies for diagnosis of OSA
We examined differences in OSA metrics obtained from two devices with divergent home monitoring strategies, the Apnea Risk Evaluation System (ARES ™, multiple signals plus forehead reflectance oximetry) and the Nonin WristOx2™ (single channel finger transmission pulse oximeter), compared to differences from night-night variability of OSA.MethodsOne hundred fifty-two male/26 female subjects (BMI  = 30.3 ± 5.6 kg/m2, age  = 52.5 ± 8.9 years) were recruited without regard to OSA symptoms and simultaneously wore both ARES™ and Nonin WristOx2&trad...
Source: Sleep and Breathing - August 19, 2017 Category: Respiratory Medicine Source Type: research

Depressive symptoms are associated with poor sleep quality rather than apnea-hypopnea index or hypoxia during sleep in patients with obstructive sleep apnea
We examined factors, including the severity of obstructive sleep apnea (OSA), that were associated with depressive symptoms and excessive daytime sleepiness in OSA patients.MethodsWe retrospectively reviewed data of 1203 subjects (861 men, mean age 48.2  years) who completed self-reported questionnaires and underwent polysomnography between September 2005 and May 2016 at the Center for Sleep and Chronobiology at Seoul National University Hospital. We compared scores on the Beck Depression Inventory (BDI) and Epworth sleepiness scale (ESS) between OSA and control groups. Analyses for OSA subgroups were classified by se...
Source: Sleep and Breathing - August 19, 2017 Category: Respiratory Medicine Source Type: research

Sex-based differences in respiratory control: Progress in basic physiology and clinical research
Publication date: Available online 19 August 2017 Source:Respiratory Physiology & Neurobiology Author(s): Richard Kinkead, Evelyn Schlenker (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - August 19, 2017 Category: Respiratory Medicine Source Type: research

Intranasal co-administration of 1,8-cineole with influenza vaccine provide cross-protection against influenza virus infection
Conclusion These results suggest that 1,8-cineole (12.5 mg/kg) has a cross-protection against influenza virus, co-administered with inactivated influenza viral antigen in a mouse model. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 19, 2017 Category: Drugs & Pharmacology Source Type: research

Assessment of exposure to pesticides in rural workers in southern of Minas Gerais, Brazil
Publication date: Available online 18 August 2017 Source:Environmental Toxicology and Pharmacology Author(s): Alessandra Cristina Pupin Silvério, Simone Caetani Machado, Luciana Azevedo, Denismar Alves Nogueira, Miriam Monteiro de Castro Graciano, Juliana Savioli Simões, André Luiz Machado Viana, Isarita Martins The aim of the study was to assess of occupational exposure to pesticides in rural workers using genotoxicity test, bioindicators and clinical evaluation. Blood, urine and buccal samples from persons, rural workers exposed to a complex mixture of pesticides with organophosphates (n=94) and wit...
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

Prevalence and characteristics of inhalational and dermal palytoxin exposures reported to the National Poison Data System in the U.S.
Conclusion The incidence of palytoxin exposure is low but significant symptoms can occur. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - August 19, 2017 Category: Environmental Health Source Type: research

The role of the lectin-like oxLDL receptor (LOX-1) in traffic-generated air pollution exposure-mediated alteration of the brain microvasculature in Apolipoprotein (Apo) E knockout mice.
Authors: Lucero J, Suwannasual U, Herbert LM, McDonald JD, Lund AK Abstract Recent studies have shown a strong correlation between air pollution-exposure and detrimental outcomes in the central nervous system, including alterations in blood brain barrier (BBB) integrity, neuroinflammation, and neurodegeneration. However, the mechanisms mediating these pathologies have not yet been fully elucidated. We have previously reported that exposure to traffic-generated air pollution results in increased circulating oxidized low-density lipoprotein (oxLDL), associated with alterations in BBB integrity, in atherosclerotic Apo...
Source: Inhalation Toxicology - August 18, 2017 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

MiR-541-5p regulates lung fibrosis by targeting cyclic nucleotide phosphodiesterase 1A.
CONCLUSIONS: MiR-541-5p is a key effector in lung fibroblastsby by regulating PDE1A expression at protein translation level and its overexpression is protective against bleomycin-induced lung fibrosis. PMID: 28816543 [PubMed - as supplied by publisher] (Source: Experimental Lung Research)
Source: Experimental Lung Research - August 18, 2017 Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research

Are Inner-City Children with Asthma Receiving Specialty Care as Recommended in National Asthma Guidelines?
CONCLUSIONS: In contrast to guideline recommendations, few inner-city children with high asthma morbidity in this sample had seen asthma specialists. Efforts are needed to ensure that inner-city children with asthma are receiving guideline recommended asthma specialty care. PMID: 28813166 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Validating the Concept of COPD Control: A Real-world Cohort Study from the United Kingdom.
Authors: Nibber A, Chisholm A, Soler-Cataluña JJ, Alcazar B, Price D, Miravitlles M Abstract The concept of Chronic Obstructive Pulmonary Disease (COPD) control has been developed to inform therapeutic decision-making. We explored the validity of a definition of COPD control in a representative population of patients with COPD in the United Kingdom. Electronic medical records and linked COPD questionnaire data from the Optimum Patient Care Research Database were used to characterize control status. Patients were aged ≥40 years, with spirometry-confirmed COPD, current or ex-smokers, and continuous rec...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - August 18, 2017 Category: Respiratory Medicine Tags: COPD Source Type: research