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Time-dependent changes in cardiorespiratory functions of anesthetized rats exposed to sustained hypoxia.
Abstract Although cardiovascular responses may be altered by respiratory changes under prolonged hypoxia, the relationship between respiratory and cardiovascular changes remains unknown. The aim of the present study is to clarify cardiorespiratory changes in anesthetized rats during and after hypoxic conditions using simultaneous recordings of cardiorespiratory variables with 20-sec recording intervals. After air breathing for 20 min (pre-exposure period), rats were subjected to 10% O2 for 2 h (hypoxic exposure period) and then air for 30 min (recovery period). Minute ventilation (VE), respiratory frequency,...
Source: Autonomic Neuroscience - May 22, 2018 Category: Neuroscience Authors: Kato K, Morinaga R, Fushuku S, Nakamuta N, Yamamoto Y Tags: Auton Neurosci Source Type: research

Depth-Based Whole Body Photoplethysmography in Remote Pulmonary Function Testing
Conclusion: We introduce a depth-based whole body photoplethysmography approach, which reduces motion artifacts in depth-based volume–time data and highly improves the accuracy of depth-based computed measures. Significance: The proposed dPPG method remarkably drops the $L_2$ error mean and standard deviation of FEF$_{50%}$ , FEF$_{75%}$ , FEF$_{25-75%}$, IC , and ERV measures by half, compared to the single Kinect approach. These significant improvements establish the potential for unconstrained remote respiratory monitoring and diagnosis. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - May 22, 2018 Category: Biomedical Engineering Source Type: research

GSE114707 Expression data from allergic patients to profilin
Contributors : Leticia Mera ; Paloma Fern ández ; Isabel A Martín-AntonianoSeries Type : Expression profiling by arrayOrganism : Homo sapiensPrevalence and severity of allergic diseases have increased worldwide. To date, respiratory allergy phenotypes are not fully characterized and, along with inflammation progression, treatment is increasingly complex and expensive. Profilin sensitization constitutes a good model to study the progression of allergic inflammation.We have used microarrays to understand the underlying mechanisms of severe profilin-mediated reactions using a model that includes patients with di...
Source: GEO: Gene Expression Omnibus - May 22, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Resting spontaneous baroreflex sensitivity and cardiac autonomic control in anabolic androgenic steroid users
CONCLUSIONS: Our results provide evidence for lower baroreflex sensitivity and sympathovagal imbalance in anabolic androgenic steroid users. Moreover, anabolic androgenic steroid users showed arterial stiffness. Together, these alterations might be the mechanisms triggering the increased blood pressure in this population. (Source: Clinics)
Source: Clinics - May 22, 2018 Category: General Medicine Source Type: research

Tonsillar cytokine expression between patients with tonsillar hypertrophy and recurrent tonsillitis
AbstractBackgroundTonsils provide an innovative in vivo model for investigating immune response to infections and allergens. However, data are scarce on the differences in tonsillar virus infections and immune responses between patients with tonsillar hypertrophy or recurrent tonsillitis. We investigated the differences in virus detection and T cell and interferon gene expression in patients undergoing tonsillectomy due to tonsillar hypertrophy or recurrent tonsillitis.MethodsTonsils of 89 surgical patients with tonsillar hypertrophy (n  = 47) or recurrent tonsillitis (n = 42) were analysed. Pat...
Source: Clinical and Translational Allergy - May 22, 2018 Category: Allergy & Immunology Source Type: research

Outcomes of hypoxic respiratory failure at birth associated with previable rupture of membranes
Outcomes of hypoxic respiratory failure at birth associated with previable rupture of membranes, Published online: 22 May 2018; doi:10.1038/s41372-018-0131-xOutcomes of hypoxic respiratory failure at birth associated with previable rupture of membranes (Source: Journal of Perinatology)
Source: Journal of Perinatology - May 22, 2018 Category: Perinatology & Neonatology Authors: Michelle Baczynski Shannon Ginty Dany Weisz Patrick J McNamara Edmond Kelly Prakesh S Shah Amish Jain Source Type: research

Rapid molecular test for tuberculosis: impact of its routine use at a referral hospital
Conclusions: The use of the Xpert MTB/RIF test, under routine conditions, significantly increased the detection of cases of tuberculosis among sputum smear-negative patients.RESUMO Objetivo: Avaliar o impacto do teste r ápido molecular automatizado Xpert MTB/RIF, utilizado para a detecção de Mycobacterium tuberculosis e sua resistência à rifampicina, em condições de rotina, em um hospital de referência no estado da Bahia. Métodos: Estudo descritivo retrospectivo utilizando o banco de dados do Laboratório de Micobacteriologia do Hospital Especializado Oct&a...
Source: Jornal Brasileiro de Pneumologia - May 21, 2018 Category: Respiratory Medicine Source Type: research

[A very unusual pleural presentation].
We report a case of urinothorax presenting as a purulent pleural effusion. Management of the urinothorax required antibiotics and surgical unblocking of the urinary tract. Currently, no test is available to confirm the diagnosis. The ratio of serum creatinine/pleural creatinine could suggest the presence of urinothorax but this parameter needs to be validated by complementary studies. Urinothorax should be suspected in the context of pleural effusion occurring after a recent urologic surgery. PMID: 29778619 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 21, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Factors associated with non-conversion of the direct smear after the initial phase of anti-tuberculous treatment. A study undertaken in three tuberculosis management centres in South Benin].
The objective of this work was to describe the profile of routinely managed tuberculosis patients whose sputum smear did not become negative after the initial phase of anti-tuberculous treatment and to analyze the factors associated with this. With this aim a cross-sectional, retrospective, descriptive and analytical study was carried out in a population of adults with pulmonary tuberculosis (PTB) between 2013 and 2014 in three cities in southern Benin (Cotonou, Porto-Novo and Abomey). The data of the patients who did not convert (PTB +) were compared with those who did (PTB-). A multivariate logistic regression analysis w...
Source: Revue des Maladies Respiratoires - May 21, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Pneumothorax in young cannabis smokers: A propos of three  cases].
CONCLUSION: The presence of emphysema in young cannabis smokers complicates the management of spontaneous pneumothorax. In this context, a first-line surgical intervention may be an option to be considered. PMID: 29776705 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 21, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[Surgical treatment of early stage non-small cell lung cancer by thoracoscopic segmental resection].
CONCLUSION: For early stage NSCLC, thoracoscopic ASLR allows reduced perioperative morbidity while offering satisfactory survival. However, a rigorous technique must be applied to reduce the rates of conversion to thoracotomy and extension to lobectomy when required for oncological reasons. PMID: 29778621 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 21, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

[How to set up a non-invasive ventilation?]
Authors: Grassion L, Llontop C, Layachi L, Hubert E, Morelot-Panzini C, Gonzalez-Bermejo J PMID: 29778622 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 21, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Economic Cost Analysis Related to Complications in General and Digestive Surgery
Publication date: Available online 21 May 2018 Source:Cirugía Española (English Edition) Author(s): Juan-Carlos Gomez-Rosado, Jose Salas-Turrens, Antonio Olry-de-Labry-Lima Introduction The aim was to assess the impact on economic costs and length of stay (LOS) of postoperative complications. Methods 5822 records from BMDS (2014–2015) are included. A descriptive, univariate and multivariate study evaluated the correlation between complications, Clavien-Dindo grade and vacation periods with LOS and economic costs, based on a full-cost model, aggregated by DRG. Results and conclusions Mean cost per stay ...
Source: Cirugia Espanola - May 21, 2018 Category: Surgery Source Type: research

Occupational risk factors for idiopathic pulmonary fibrosis in Southern Europe: a case-control study
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia of unknown cause associated with the histopathologic and/or radiologic pattern of usual interstitial pneumonia (UI... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - May 21, 2018 Category: Respiratory Medicine Authors: Giulia Paolocci, Ilenia Folletti, Kjell Tor én, Magnus Ekström, Marco Dell’Omo, Giacomo Muzi and Nicola Murgia Tags: Research article Source Type: research

Relationship between pulmonary function and peripheral vascular function in older Chinese: Guangzhou biobank cohort study-CVD
Findings describing the relationship between pulmonary function and peripheral vascular function have been inconclusive. We explored this relationship in Guangzhou Biobank Cohort Study-Cardiovascular Subcohort... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - May 21, 2018 Category: Respiratory Medicine Authors: Jing Pan, Lin Xu, Tai Hing Lam, Chao Qiang Jiang, Wei Sen Zhang, Feng Zhu, Ya Li Jin, G. Neil Thomas, Kar Keung Cheng and Peymane Adab Tags: Research article Source Type: research

Risk factors for mortality in patients with Pseudomonas aeruginosa pneumonia: Clinical impact of mucA gene mutation
Pseudomonas aeruginosa frequently colonizes the lungs of chronic obstructive pulmonary disease (COPD) patients. Mucoid conversion is a hallmark of chronic P. aeruginosa infection, which is mediated by mucA gene mutations. The aim of this study is to identify predictive factors for mortality and the influence of mucA gene mutation in COPD patients with P. aeruginosa pneumonia. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 21, 2018 Category: Respiratory Medicine Authors: In Young Jung, Su Jin Jeong, Kang-Mu Lee, Jin Young Ahn, Nam Su Ku, Sang Hoon Han, Jun Yong Choi, Dongeun Yong, Sang Sun Yoon, Young Goo Song, Seok Hoon Jeong, June Myung Kim, Kyungwon Lee Source Type: research

Within and between day repeatability of the incremental shuttle walking test in patients with thoracic cancer
Breathlessness is common in patients with thoracic cancer but difficult to manage. The Incremental Shuttle Walking Test (ISWT) can help assess new treatments, but its repeatability has not been described in this group. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 21, 2018 Category: Respiratory Medicine Authors: Andrew Wilcock, Sim Koon, Cathann Manderson, Vicky Taylor, Matthew Maddocks Tags: Short communication Source Type: research

Recommendations for application of Haemophilus influenzae PCR diagnostics to respiratory specimens for children living in northern Australia: a retrospective re-analysis
This study aimed to determine the prevalence of misident... (Source: BMC Research Notes)
Source: BMC Research Notes - May 21, 2018 Category: Research Authors: Jemima Beissbarth, Michael J. Binks, Robyn L. Marsh, Anne B. Chang, Amanda J. Leach and Heidi C. Smith-Vaughan Tags: Research note Source Type: research

Lower Distending Pressure Improves Respiratory Mechanics in Congenital Diaphragmatic Hernia Complicated by Persistent Pulmonary Hypertension
To investigate the effects of distending pressures on respiratory mechanics and pulmonary circulation in newborn infants with congenital diaphragmatic hernia (CDH) and persistent pulmonary hypertension (PPHN). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 21, 2018 Category: Pediatrics Authors: David Guevorkian, Sebastien Mur, Eric Cavatorta, Laurence Pognon, Thameur Rakza, Laurent Storme Tags: Original Articles Source Type: research

Review of Maternal Mortality at a Tertiary Care Hospital: What Have we Achieved?
ConclusionStrengthening of the peripheral centers, hiring competent staffs and adequate blood bank facilities together with reference linkages must be done. Auditing the causes for maternal mortality is extremely helpful to identify the preventable causes and delays. (Source: The Journal of Obstetrics and Gynecology of India)
Source: The Journal of Obstetrics and Gynecology of India - May 21, 2018 Category: OBGYN Source Type: research

Clinical and Genetic Features of Congenital Myasthenic Syndromes due to CHAT Mutations: Case Report and Literature Review
We report a case of a 12-month-old female patient presented with recurrent episodic apnea carrying a mutation in CHAT gene, p.I336T. Furthermore, we describe the genetic and clinical findings in 44 CMS patients due to CHAT mutations in the literature up to date. Episodes of apnea and respiratory insufficiency are the hallmarks of CHAT mutations. Clinical manifestations usually provoked by infections and fever. CMS due to CHAT mutations are rare, but it is important to diagnosis. Early diagnosis and appropriate treatment can improve morbidity and mortality. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in ...
Source: Neuropediatrics - May 21, 2018 Category: Neurology Authors: Arican, Pinar Gencpinar, Pinar Cavusoglu, Dilek Olgac Dundar, Nihal Tags: Short Communication Source Type: research

The effect of aspirin in preventing the acute respiratory distress syndrome/acute lung injury: A meta-analysis
The effects of aspirin in preventing the occurrence of acute respiratory distress syndrome (ARDS)/acute lung injury (ALI) among adult patients are controversial. We aimed to further determine the effectiveness of aspirin in reducing the rate of ARDS/ALI. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - May 21, 2018 Category: Emergency Medicine Authors: He Yu, Yue-Nan Ni, Zong-An Liang, Bin-Miao Liang, Yanmei Wang Source Type: research

Chronic Multifocal Paracoccidioidomycosis: Pulmonary and Cutaneous Involvement
A 50-year-old man presented with a 14-month history of dyspnea, cutaneous ulceration on the labial commissure, and an 18-kg weight loss since the onset of the condition. He had been a smoker and an alcoholic for the last 35  years. Positive findings on physical examination included an erythematous infiltrated plaque with an ulcer on left labial commissure (Figure 1), an ulcer with hemorrhagic dots on the first left toe (Figure 2), and respiratory crackles in the upper two-thirds of both lung fields. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - May 21, 2018 Category: Emergency Medicine Authors: Fred Bernardes Filho, Rodolfo Mendes Queiroz, Loan Towersey, Roderick Hay, Marcus Vinicius Nascimento Valentin Tags: Visual Diagnosis in Emergency Medicine Source Type: research

Prolonged forearm ischemia attenuates endothelium-dependent vasodilatation and plasma nitric oxide metabolites in overweight middle-aged men
AbstractPurposeRepeated cycles of endothelial ischemia –reperfusion injury and the resulting respiratory burst contribute to the irreversible pathophysiology of vascular diseases, and yet, the effects of ischemia reperfusion on vascular function, oxidative stress, and nitric oxide (NO) bioavailability have not been assessed simultaneously. Therefore, this study sought to examine the effects of prolonged forearm occlusion and subsequent reperfusion on NO-dependent brachial artery endothelial function.MethodsFlow-mediated dilatation was measured at baseline and 15, 30, and 45  min after 20-min forearm occlusion in...
Source: European Journal of Applied Physiology - May 21, 2018 Category: Physiology Source Type: research

A case of decompression illness not responding to hyperbaric oxygen
ConclusionsDecompression illness results as a sudden decrease in pressures during underwater ascent; it is caused by nitrogen bubbles forming in tissue. Additionally, a patent foramen ovale allows arterial gas emboli to cause further harm. Type 2 decompression sickness is the more severe form and includes neurological, respiratory, and cardiovascular symptoms. (Source: Journal of Intensive Care)
Source: Journal of Intensive Care - May 21, 2018 Category: Intensive Care Source Type: research

Assessing Mortality Models in Systemic Sclerosis-Related Interstitial Lung Disease
ConclusionsThe ILD-GAP model underestimated mortality, and the SADL model underestimated mortality in certain subgroups. However, the GAP model performed well in this cohort, providing the best prognostic information for SSc-ILD. (Source: Lung)
Source: Lung - May 21, 2018 Category: Respiratory Medicine Source Type: research

Knockdown of annexin A5 restores gefitinib sensitivity by promoting G2/M cell cycle arrest
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, including gefitinib, are first-line drugs against advanced non-small cell lung cancer with activating EGFR mutations. However, the developmen... (Source: Respiratory Research)
Source: Respiratory Research - May 21, 2018 Category: Respiratory Medicine Authors: Jian Zhou, Meijia Chang, Jing Li, Tao Fang, Jie Hu and Chunxue Bai Tags: Research Source Type: research

Soluble urokinase plasminogen activator receptor predicts mortality in exacerbated COPD
The inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is elevated in severe acute and chronic medical conditions and has been associated with short-term mortality. The role of suP... (Source: Respiratory Research)
Source: Respiratory Research - May 21, 2018 Category: Respiratory Medicine Authors: Nina S. Godtfredsen, Ditte V. J ørgensen, Kristoffer Marsaa, Charlotte S. Ulrik, Ove Andersen, Jesper Eugen-Olsen and Line J. H. Rasmussen Tags: Research Source Type: research

Safety, tolerability, pharmacokinetics, and pharmacodynamics of GLPG1690, a novel autotaxin inhibitor, to treat idiopathic pulmonary fibrosis (FLORA): a phase 2a randomised placebo-controlled trial
Publication date: Available online 20 May 2018 Source:The Lancet Respiratory Medicine Author(s): Toby M Maher, Ellen M van der Aar, Olivier Van de Steen, Lisa Allamassey, Julie Desrivot, Sonia Dupont, Liesbeth Fagard, Paul Ford, Ann Fieuw, Wim Wuyts Background Idiopathic pulmonary fibrosis (IPF) causes irreversible loss of lung function. People with IPF have increased concentrations of autotaxin in lung tissue and lysophosphatidic acid (LPA) in bronchoalveolar lavage fluid and exhaled condensate. GLPG1690 (Galapagos, Mechelen, Belgium) is a novel, potent, selective autotaxin inhibitor with good oral exposure. We explored ...
Source: The Lancet Respiratory Medicine - May 21, 2018 Category: Respiratory Medicine Source Type: research

Tralokinumab for severe, uncontrolled asthma (STRATOS 1 and STRATOS 2): two randomised, double-blind, placebo-controlled, phase 3 clinical trials
Publication date: Available online 20 May 2018 Source:The Lancet Respiratory Medicine Author(s): Reynold A Panettieri, Ulf Sjöbring, AnnaMaria Péterffy, Peter Wessman, Karin Bowen, Edward Piper, Gene Colice, Christopher E Brightling Background Tralokinumab is an anti-interleukin-13 human monoclonal antibody developed for the treatment of severe, uncontrolled asthma. These clinical trials aimed to assess the efficacy and safety of tralokinumab in this population. Methods STRATOS 1 and STRATOS 2 were randomised, double-blind, parallel-group, placebo-controlled, phase 3 clinical trials that enrolled participants ...
Source: The Lancet Respiratory Medicine - May 21, 2018 Category: Respiratory Medicine Source Type: research

Management of children and young people (CYP) with asthma: a clinical audit report
Management of children and young people (CYP) with asthma: a clinical audit report, Published online: 21 May 2018; doi:10.1038/s41533-018-0087-5Encouraging self-reflection and best practice can help doctors improve patient care following asthma attacks. A recent UK national review uncovered multiple shortfalls in asthma management. Mark Levy at Harrow Clinical Commissioning Group in London and co-workers conducted a clinical asthma audit to assess the after-care of 291 patients under the age of 19 who had been treated for an asthma attack in Harrow during 2016. Analysis of patient records showed that risks of future attack...
Source: npj Primary Care Respiratory Medicine - May 21, 2018 Category: Primary Care Authors: Mark L Levy Angela Ward Sara Nelson Source Type: research

Drooling in Parkinson ’s Disease: Evidence of a Role for Divided Attention
This study assessed whether frequency of saliva swallows reduced, and drooling severity and frequency increased, when people with PD engaged in a cognitively distracting task. 18 patients with idiopathic PD reporting daytime dro oling on the Unified Parkinson’s Disease Rating Scale (UPDRS) were recruited. They completed the Radboud Oral Motor Inventory for PD saliva questionnaire and the Montreal Cognitive Assessment. UPDRS drooling score, disease stage, duration, gender, and age were recorded. Swallow frequency and drool ing severity and frequency were measured at rest and during a distracting computer-based languag...
Source: Dysphagia - May 21, 2018 Category: Speech-Language Pathology Source Type: research

Multiple Exposures and Coexposures to Occupational Hazards Among Agricultural Workers: A Systematic Review of Observational Studies
Conclusion Few studies have explored the impact of multiple occupational exposures on the health of agricultural workers. A very limited number of studies have investigated the effect of coexposures among biomechanical, physical, and chemical hazards on occupational health, which indicates a need for further research in this area. (Source: Safety and Health at Work)
Source: Safety and Health at Work - May 21, 2018 Category: Occupational Health Source Type: research

Intravenous Low-Dose Ketamine Provides Greater Pain Control Compared to Fentanyl in a Civilian Prehospital Trauma System: A Propensity Matched Analysis.
The objective of this study is to compare pain control between low-dose ketamine and fentanyl when administered intravenously (IV) for the indication of severe pain. METHODS: This was a retrospective, observational review of prehospital adult patients (≥18 years) who presented with severe pain (numeric rating scale, 7-10) and were treated solely with either low-dose ketamine IV or fentanyl IV between January 1, 2014 and December 31, 2016. Propensity matched analysis was performed adjusting for all baseline variables with p ≤ 0.10 and for baseline pain score to match ketamine and fentanyl patients on a one-to...
Source: Prehospital Emergency Care - May 20, 2018 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

[The obstructive sleep apnoea syndrome is not only bad for the heart!]
We report the case of a 79-year-old man with severe, undiagnosed OSA who inhaled his fixed dental bridge during sleep. The inhaled foreign body came to rest in the lumen of the left main stem bronchus. The association of obesity with a body mass index of 30kg/m2, snoring with breathing pauses reported by his partner, nocturia, morning headache and an Epworth score of 11 led to polysomnography which confirmed OSA with an apnoea/hypopnoea index of 53 per hour. This case report emphasises that OSA may constitute a risk fact for foreign body inhalation in elderly subjects due to arousal-induced hyperventilation following the a...
Source: Revue des Maladies Respiratoires - May 20, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection
New England Journal of Medicine, Ahead of Print. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - May 20, 2018 Category: Internal Medicine Authors: David T. Huang Donald M. Yealy Michael R. Filbin Aaron M. Brown Chung-Chou H. Chang Yohei Doi Michael W. Donnino Jonathan Fine Michael J. Fine Michelle A. Fischer John M. Holst Peter C. Hou John A. Kellum Feras Khan Michael C. Kurz Shahram Lotfipour Frank Source Type: research

Reconstruction of the Central Airways: From the Aorta to the Trachea
In this issue ofJAMA, Martinod and colleagues report the results of a prospective, single-institution safety and feasibility trial of airway transplantation to reconstruct long-segment defects of the trachea and central bronchi. Over 6.5 years, 13 of 20 patients with end-stage tracheal lesions or proximal lung tumors requiring a pneumonectomy were enrolled in the study and underwent airway reconstruction with cryopreserved aortic allografts following definitive resection. Custom-made stents to support the allografts were used initially to prevent airway collapse but were removed at a postoperative mean duration of 18 month...
Source: JAMA - Journal of the American Medical Association - May 20, 2018 Category: General Medicine Source Type: research

Solubilization conditions for bovine heart mitochondrial membranes allow selective purification of large quantities of respiratory complexes I, III, and V
Publication date: October 2018 Source:Protein Expression and Purification, Volume 150 Author(s): Satoru Shimada, Shintaro Maeda, Masahide Hikita, Kaoru Mieda-Higa, Shigefumi Uene, Yukiko Nariai, Kyoko Shinzawa-Itoh Ascertaining the structure and functions of mitochondrial respiratory chain complexes is essential to understanding the biological mechanisms of energy conversion; therefore, numerous studies have examined these complexes. A fundamental part of that research involves devising a method for purifying samples with good reproducibility; the samples obtained need to be stable and their constituents need to retain th...
Source: Protein Expression and Purification - May 20, 2018 Category: Biochemistry Source Type: research

Single exposure to aerosolized graphene oxide and graphene nanoplatelets did not initiate an acute biological response in a 3D human lung model
Publication date: October 2018 Source:Carbon, Volume 137 Author(s): Barbara Drasler, Melanie Kucki, Flavien Delhaes, Tina Buerki-Thurnherr, Dimitri Vanhecke, Daria Korejwo, Savvina Chortarea, Hana Barosova, Cordula Hirsch, Alke Petri-Fink, Barbara Rothen-Rutishauser, Peter Wick The increased mass production of graphene related materials (GRM), intended for a broad spectrum of applications, demands a thorough assessment of their potential hazard to humans and the environment. Particularly, the paramount concern has been expressed in regard to their interaction with the respiratory system in occupational exposure settings. ...
Source: Carbon - May 20, 2018 Category: Materials Science Source Type: research

A prospective, multi-centre US clinical trial to determine accuracy of FebriDx point-of-care testing for acute upper respiratory infections with and without a confirmed fever.
CONCLUSION: FebriDx may identify clinically significant bacterial URI's and supports outpatient antibiotic decisions. Key messages FebriDx is an outpatient POC test designed to identify a clinically significant systemic host immune response and aid in the differentiation of viral and bacterial infection through rapid measurement of MxA and CRP from a fingerstick blood sample. FebriDx test was determined to be an accurate test, with a 85% sensitivity, 93% specificity and 97% NPV to rule out bacterial infection for any patient presenting with symptoms and reported fever within the prior 3 days, and when confirming fever (hyp...
Source: Annals of Medicine - May 19, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Comparison between dexmedetomidine and midazolam as a sedation agent with local anesthesia in inguinal hernia repair: randomized controlled trial
ConclusionThis study demonstrated that intravenous dexmedetomidine during hernia repair with local anesthesia is safe and the results were satisfactory to both operators and patients. (Source: Hernia)
Source: Hernia - May 19, 2018 Category: Sports Medicine Source Type: research

An overview of glycopyrrolate/eFlow ® CS in COPD.
An overview of glycopyrrolate/eFlow® CS in COPD. Expert Rev Respir Med. 2018 May 18;: Authors: Kerwin E, Ferguson GT Abstract INTRODUCTION: COPD is highly prevalent in the US and globally, requiring new treatment strategies due to the high disease burden and increase in the aging population. Here, we profile the newly FDA-approved LONHALA MAGNAIR (glycopyrrolate [GLY]/eFlow® Closed System [CS]; 25 mcg twice daily), a nebulized long-acting muscarinic antagonist (LAMA) for the long-term maintenance treatment of COPD, including chronic bronchitis and/or emphysema. Areas covered: An overview of COP...
Source: Expert Review of Respiratory Medicine - May 19, 2018 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Concordance between survey reported childhood asthma and linked Medicaid administrative records.
CONCLUSIONS: There was general agreement between asthma diagnoses reported in the NHIS when compared to medical claims. Discordance was greatest among children with co-occurring conditions. PMID: 29771597 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 19, 2018 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Clinical characterization of children with resistant airflow obstruction, a multicenter study.
CONCLUSIONS: The most prevalent diagnosis in children with BD-resistant airflow limitation is asthma. Allergic rhinitis and premature birth are common co-morbidities. Children without a history of asthma, as well as those with asthma but no allergic rhinitis, had lower pulmonary function. Children with BD-resistant airflow limitation may represent a sub-group of children with persistent obstruction and high risk for life-long airway disease. PMID: 29771599 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 19, 2018 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Myotonia permanens with Nav1.4-G1306E displays varied phenotypes during course of life.
Discussion: Residue G1306 Neonatal laryngospasm and unusual distribution of myotonia, muscle hypertrophy, and weakness encourage direct search for the G1306E mutation, a hotspot for de-novo mutations. Successful therapy with the sodium channel blocker flecainide is due to stabilization of the inactivated state and special effectiveness for enlarged window currents. Our G1306E collection is the first genetically clarified case series from newborn period to adulthood and therefore helpful for counselling. PMID: 29774303 [PubMed - in process] (Source: Acta Myologica)
Source: Acta Myologica - May 19, 2018 Category: Neurology Tags: Acta Myol Source Type: research

Bethlem myopathy in a Portuguese patient - case report.
We present a male patient of 49 years old, with symptoms of muscle weakness beginning in childhood and of very slowly progression. At the age of 42, the neurological examination revealed proximal lower limb muscle weakness and contractures of fingers flexors muscles, positive Gowers manoeuvre and a waddling gait. Serum creatine kinase (CK) values were slightly elevated, electromyographic study revealed myopathic changes and muscle MRI of the lower limbs showed a specific pattern of muscle involvement, with peripheral fat infiltration in vastus lateralis and intermedius and anterocentral infiltration in rectus femoris. Resp...
Source: Acta Myologica - May 19, 2018 Category: Neurology Tags: Acta Myol Source Type: research

Estimating the Hospital Delivery Costs Associated With Severe Maternal Morbidity in New York City, 2008-2012.
(Obstet Gynecol. 2018;131(2):242–252) Rates of maternal morbidity and mortality have been increasing in the United States over the past decade. However, there is minimal information regarding the economic burden associated with these events, which include blood transfusion, hysterectomy, disseminated intravascular coagulation, adult respiratory distress syndrome, and acute renal failure. In the present study, to evaluate the cost-effectiveness of current interventions, the authors quantified the average and total hospital costs associated with severe maternal morbidity over a 5-year period within the 5 boroughs of N...
Source: Obstetric Anesthesia Digest - May 19, 2018 Category: Anesthesiology Tags: Editorials and Reviews Source Type: research

Risk of Neonatal Drug Withdrawal after Intrauterine Coexposure to Opioids and Psychotropic Medications: Cohort Study
(BMJ. 2017;358:j3326) Neonatal abstinence syndrome is a recognized complication of intrauterine exposure to opioids. Neonatal abstinence syndrome can manifest in a number of different ways, from difficulty feeding and sleeping to more severe complications such as impaired thermoregulation, seizures, failure to thrive, and respiratory distress. Because pregnant women who are using an opioid often also use psychotropic medications, there are concerns about potential interactions between the opioid and psychotropic drugs leading to an increase in the occurrence and severity of neonatal drug withdrawal from. However, not much...
Source: Obstetric Anesthesia Digest - May 19, 2018 Category: Anesthesiology Tags: Mother, Fetus, Neonate Source Type: research

Pleural Fluid B-Type Natriuretic Peptide Level as an Additional Indicator for the Fluid's Etiology.
Authors: Zalts R, Twizer T, Leiba R, Karban A Abstract BACKGROUND: The identification of the etiology of a pleural effusion can be difficult. Measurement of serum B-type natriuretic peptide (BNP) levels is helpful in the diagnosis of congestive heart failure (CHF) as a cause of respiratory failure, but pleural fluid BNP measurement is still not part of the workup for pleural effusion. OBJECTIVES: To identify the correlation between pleural fluid BNP levels and clinical diagnosis. METHODS: In this cross-sectional study, data from 107 patients admitted to the department of internal medicine between November 2...
Source: The Israel Medical Association Journal - May 19, 2018 Category: General Medicine Tags: Isr Med Assoc J Source Type: research

Ultrasound of Jugular Veins for Assessment of Acute Dyspnea in Emergency Departments and for the Assessment of Acute Heart Failure.
CONCLUSIONS: Ultrasound of the IJV may be a useful tool for the diagnosis of ADHF because it is easy to measure and requires little skill. It is also not affected by patient body habitus. PMID: 29761678 [PubMed - in process] (Source: The Israel Medical Association Journal)
Source: The Israel Medical Association Journal - May 19, 2018 Category: General Medicine Tags: Isr Med Assoc J Source Type: research