Unraveling the Molecular Regulation of Ferroptosis in Respiratory Diseases
(Source: Journal of Inflammation Research)
Source: Journal of Inflammation Research - April 24, 2024 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
< em > Paucibacter sediminis < /em > sp. nov., isolated from sediment in a freshwater pond
Int J Syst Evol Microbiol. 2024 Apr;74(4). doi: 10.1099/ijsem.0.006312.ABSTRACTA Gram-stain-negative, aerobic, oxidase-positive, weakly catalase-positive, motile by means of a single polar flagellum, rod-shaped bacterium designated as strain S2-9T was isolated from sediment sampled in Wiyang pond, Republic of Korea. Growth of this strain was observed at 10-40 °C (optimum, 35 °C) and pH 5.5-9.5 (optimum, pH 7.0-8.0) and in the presence of 0-0.5 % NaCl in Reasoner's 2A broth. The major fatty acids (>10 %) of strain S2-9T were C16 : 0 and summed feature 3 (comprising a mixture of C16 : 1 ω7c and/or C16 : 1 ω6c). Ubiq...
Source: International Journal of Systematic and Evolutionary Microbiology - April 24, 2024 Category: Microbiology Authors: Ji Young Jung Mi Hwa Lee Young Ho Nam Hye-Kyeong Kang Ju Hyung Jeon Jun Sung Kim Eui Jin Kim Source Type: research
Updates on British Thoracic Society Statement on Pleural Disease and Procedures 2023
Open Respir Med J. 2023 Dec 1;17:e18743064286775. doi: 10.2174/0118743064286775231128104253. eCollection 2023.NO ABSTRACTPMID:38655073 | PMC:PMC11037506 | DOI:10.2174/0118743064286775231128104253 (Source: Open Respiratory Medicine Journal)
Source: Open Respiratory Medicine Journal - April 24, 2024 Category: Respiratory Medicine Authors: Ashish Subedi Prakash Banjade Sushil Joshi Munish Sharma Salim Surani Source Type: research
Radial Endobronchial Ultrasound-guided Transbronchial Cryobiopsy < em > versus < /em > Forceps Biopsy for the Diagnosis of Solitary Pulmonary Nodules: A Prospective Randomised Trial
CONCLUSION: Transbronchial cryobiopsy under the guidance of fluoroscopy and radial EBUS facilitates larger biopsy specimens without a significant increase in major complications. Further research is required to confirm the effect on diagnostic yield; however, our study supports a role for TB-CB in the diagnosis of SPNs and small, nodule-adjacent biopsies.CLINICAL TRIAL REGISTRATION NUMBER: Reference number of R20160213(HREC/16/RAH/37).PMID:38655074 | PMC:PMC11037509 | DOI:10.2174/0118743064262132230922110818 (Source: Open Respiratory Medicine Journal)
Source: Open Respiratory Medicine Journal - April 24, 2024 Category: Respiratory Medicine Authors: Michael Brown Phan Nguyen Hubertus Jersmann Mark Holmes Michelle Wong Source Type: research
Evidence-based Practice Interventions for Reducing Postoperative Pulmonary Complications: A Narrative Review
CONCLUSION: The literature review concluded that patients who received multiple interventions showed significant improvement in pulmonary function postoperatively. However, definitive studies need to be conducted to solidify this conclusion.PMID:38655075 | PMC:PMC11037507 | DOI:10.2174/012210299X247199231128100613 (Source: Open Respiratory Medicine Journal)
Source: Open Respiratory Medicine Journal - April 24, 2024 Category: Respiratory Medicine Authors: Gagandeep Dhillon Venkata S Buddhavarapu Harpreet Grewal Ripudaman Munjal Ram Kishun Verma Salim Surani Rahul Kashyap Source Type: research
A Bioinformatic Algorithm based on Pulmonary Endoarterial Biopsy for Targeted Pulmonary Arterial Hypertension Therapy
CONCLUSION: We describe a new potential paradigm in the therapy for PAH, which would include endoarterial biopsy, molecular analysis and tailored pharmacological therapy for patients with PAH.PMID:38655076 | PMC:PMC11037516 | DOI:10.2174/18743064-v17-230927-2023-9 (Source: Open Respiratory Medicine Journal)
Source: Open Respiratory Medicine Journal - April 24, 2024 Category: Respiratory Medicine Authors: Abraham Rothman David Mann Jose A Nunez Reinhardt Tarmidi Humberto Restrepo Valeri Sarukhanov Roy Williams William N Evans Source Type: research
Lipid Deficiency Contributes to Impaired Alveolar Progenitor Cell Function in Aging and Idiopathic Pulmonary Fibrosis
Am J Respir Cell Mol Biol. 2024 Apr 24. doi: 10.1165/rcmb.2023-0290OC. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is an aging-associated interstitial lung disease resulting from repeated epithelial injury and inadequate epithelial repair. Alveolar type II cells (AEC2) are progenitor cells that maintain epithelial homeostasis and repair the lung after injury. In the current study, we assessed lipid metabolism in AEC2s from human lungs of IPF patients and healthy donors, as well as AEC2s from bleomycin-injured young and old mice. Through single cell RNA sequencing (scRNA-seq), we observed that lipid me...
Source: American Journal of Respiratory Cell and Molecular Biology - April 24, 2024 Category: Molecular Biology Authors: Jiurong Liang Guanling Huang Xue Liu Xuexi Zhang Anas Rabata Ningshan Liu Kai Fang Forough Taghavifar Kristy Dai Vrishika Kulur Dianhua Jiang Paul W Noble Source Type: research
< em > Pseudomonas aeruginosa < /em > Lipid A Structural Variants Induce Altered Immune Responses
Am J Respir Cell Mol Biol. 2024 Apr 24. doi: 10.1165/rcmb.2024-0059OC. Online ahead of print.ABSTRACTPseudomonas aeruginosa causes chronic lung infection in cystic fibrosis (CF), resulting in structural lung damage and progressive pulmonary decline. P. aeruginosa in the CF lung undergoes numerous changes, adapting to host-specific airway pressures while establishing chronic infection. P. aeruginosa undergoes lipid A structural modification during CF chronic infection, not seen in any other disease state. Lipid A, the membrane anchor of lipopolysaccharide (i.e., endotoxin), comprises the majority of the outer membrane of Gr...
Source: American Journal of Respiratory Cell and Molecular Biology - April 24, 2024 Category: Molecular Biology Authors: Casey E Hofstaedter Ian P O'Keefe Charles M Met Ling Wu Jelly Vanderwoude Sunny Shin Stephen P Diggle Sebastian A Riquelme David A Rasko Yohei Doi Janette M Harro Benjamin T Kopp Robert K Ernst Source Type: research
Spectrum of sleep-disordered breathing and quality of sleep in adolescent and adult patients with spinal muscular atrophy
In conclusion, sleep-disordered breathing is common even among adult patients with spinal muscular atrophy type 2 and 3, and may show either obstructive or different types on non-obstructive features. A worse respiratory muscle function is associated to non-obstructive sleep-disordered breathing and poorer sleep quality. Sleep quality should receive greater attention especially in patients with spinal muscular atrophy type 2, who have a poorer respiratory muscle function, as it could affect their quality of life.PMID:38654474 | DOI:10.1111/jsr.14222 (Source: Journal of Sleep Research)
Source: Journal of Sleep Research - April 24, 2024 Category: Sleep Medicine Authors: Grazia Crescimanno Antonino Lupica Vito Tommasello Vincenzo Di Stefano Filippo Brighina Oreste Marrone Source Type: research
The association of fibrinogen-albumin ratio and neutrophil-lymphocyte ratio with the severity of respiratory syncytial virus infection in children
This study aimed to investigate the correlation between the fibrinogen-albumin ratio (FAR) and the severity of RSV infection and to compare its effectiveness with the neutrophil-lymphocyte ratio (NLR). This was a retrospective cohort study with patients aged from 29 days to two years who had been admitted to the pediatric clinic of our hospital. Patients were divided into four groups: group 1 (mild disease), group 2 (moderate disease), group 3 (severe disease), and group 4 (control). FAR and NLR were measured in all groups. FAR was significantly higher in group 3 than in the other groups, in group 2 than in groups 1 and 4,...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - April 24, 2024 Category: Tropical Medicine Authors: Zeynep Uze Okay Berker Okay Halil Ugur Hatipoglu Gulsen Akkoc Kamil Sahin Source Type: research
Isolation and Identification of < em > Pasteurella multocida < /em > and < em > Mannheimia haemolytica < /em > from Pneumonic Small Ruminants and Their Antibiotic Susceptibility in Haramaya District, Eastern Ethiopia
CONCLUSION: This study showed that M. haemolytica and P. multocida are the common causes of mannheimiosis and pasteurellosis in small ruminants, respectively, and isolates were resistant to commonly used antibiotics in the study area. Thus, an integrated vaccination strategy, antimicrobial resistance monitoring, and avoidance of stress-inducing factors are recommended.PMID:38655561 | PMC:PMC11039012 | DOI:10.1155/2024/5605552 (Source: The Scientific World Journal)
Source: The Scientific World Journal - April 24, 2024 Category: Science Authors: Mohammed Abdulkadir Taju Nigussie Isayas Asefa Kebede Source Type: research
Skeletal consequences of preterm birth in pigs as a model for preterm infants
This study investigated the utility of a pig model to replicate clinical features of preterm birth, including MBDP, and sought to determine if early postnatal administration of insulin-like growth factor (IGF)-1 was an effective treatment. Preterm pigs, born by caesarean section at 90% gestation, were reared in intensive care facilities (respiratory, thermoregulatory and nutritional support) and compared with sow-reared term pigs born vaginally. Preterm pigs were systemically treated with vehicle or IGF-1 (recombinant human IGF-1/BP-3, 2.25 mg/kg/day). Tissues were collected at postnatal days 1, 5, and 19 (the normal weani...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Brittany M Wilson Frank C Ko Meghan M Moran Amal Adra Martin B Rasmussen Thomas Thymann Per T Sangild D Rick Sumner Source Type: research
Arthrogryposis multiplex congenita causing hypercapnic respiratory failure and airway obstruction in an adult patient
This case highlights arthrogryposis multiplex congenita (AMC) as a rare cause of hypercapnoeic respiratory failure and airway obstruction in adults and emphasizes the usage of leak-port in tracheostomy-NIV (non-invasive-ventilation) specially in resource poor setting when the tracheostomy-NIV mask is unavailable. Key messageThis case highlights arthrogryposis multiplex congenita (AMC) as a rare cause of hypercapnoeic respiratory failure and airway obstruction in adults and emphasizes the usage of leak-port in tracheostomy-NIV (non-invasive-ventilation) specially in resource poor setting when the tracheostomy-NIV mask is un...
Source: Respirology Case Reports - April 24, 2024 Category: Respiratory Medicine Authors: Harshana Bandara,
Sathiaruban Sathiyamoorthy,
Dinusha Withana,
Tharindi Dissanayake,
Harshani Athapaththu,
Wathsala Gunasinghe Tags: CLINICAL IMAGE Source Type: research
Successful ultrathin bronchoscopy with cryobiopsy for diagnosing and removing mucus plugs in allergic bronchopulmonary mycosis mimicking lung cancer
We present a case of successful ultrathin bronchoscopy with cryobiopsy for diagnosing and removing mucus plugs in a patient with allergic bronchopulmonary mycosis mimicking lung cancer. Key messageIn patients presenting with abnormal pulmonary nodules, especially those with a history of asthma, allergic bronchopulmonary mycosis should be considered. Eosinophil counts and IgE levels should be checked in such patients. (Source: Respirology Case Reports)
Source: Respirology Case Reports - April 24, 2024 Category: Respiratory Medicine Authors: Yuki Takigawa,
Hiromi Watanabe,
Ken Sato,
Mayu Goda,
Tomoyoshi Inoue,
Miho Fujiwara,
Suzuka Matsuoka,
Kenichiro Kudo,
Akiko Sato,
Keiichi Fujiwara,
Takuo Shibayama Tags: CLINICAL IMAGE Source Type: research
GSE264032 Heterogeneity of Immune Cells and Their Communications Unveiled by Transcriptome Profiling in Acute Inflammatory Lung Injury
Conclusions: This study has identified specific gene signatures and signaling pathways in animal models and human samples that facilitate the inter action between immune cells, which could be targeted therapeutically in ARDS patients of various etiologies. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
