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Viability of single balloon enteroscopy performed under endoscopist-directed sedation.
CONCLUSION: endoscopist-directed sedation is effective and safe for single balloon enteroscopy. Multi-center and wider studies are needed in order to better assess the efficacy, safety and efficiency of sedation controlled by a non-anesthetist during advanced endoscopy in this field. PMID: 29465247 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - February 25, 2018 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Respiratory rate of clinically healthy cats measured in veterinary consultation rooms
Publication date: Available online 24 February 2018 Source:The Veterinary Journal Author(s): E. Dijkstra, E. Teske, V. Szatmári Respiratory rate is commonly recorded during physical examinations. However, reference intervals are only available for resting and sleeping respiratory rates in cats at home. This observational study aimed to establish reference intervals for the respiratory rate in clinically healthy adult cats at primary-care veterinary clinics. Respiratory rates were recorded from 131 cats, in 6 primary-care veterinary clinics, by observation under four circumstances: by the investigator in the consult...
Source: The Veterinary Journal - February 25, 2018 Category: Veterinary Research Source Type: research

IJERPH, Vol. 15, Pages 394: Content of Heavy Metal in the Dust of Leisure Squares and Its Health Risk Assessment —A Case Study of Yanta District in Xi’an
IJERPH, Vol. 15, Pages 394: Content of Heavy Metal in the Dust of Leisure Squares and Its Health Risk Assessment—A Case Study of Yanta District in Xi’an International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15030394 Authors: Tianjie Shao Lihuan Pan Zhiqing Chen Ruiyuan Wang Wenjing Li Qing Qin Yuran He Taking Yanta District in Xi’an as the research object, the present study measures the contents of Cadmium (Cd), Lead (Pb), Copper (Cu), Nickel (Ni), and Chromium (Cr) in dust samples and further assesses the health risk of heavy metals intake through dust b...
Source: International Journal of Environmental Research and Public Health - February 25, 2018 Category: Environmental Health Authors: Tianjie Shao Lihuan Pan Zhiqing Chen Ruiyuan Wang Wenjing Li Qing Qin Yuran He Tags: Article Source Type: research

The curse of angiopoietin-2 in ARDS: on stranger TI(E)des
Pulmonary inflammation and vascular leakage are hallmarks of acute respiratory distress syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic treatment. (Source: Critical Care)
Source: Critical Care - February 25, 2018 Category: Intensive Care Authors: Philipp K ümpers and Alexander Lukasz Tags: Viewpoint Source Type: research

Distribution of gonadotropin-inhibitory hormone (GnIH) in male Luchuan piglets
Publication date: Available online 24 February 2018 Source:Gene Expression Patterns Author(s): Xiaoye Wang, Xun Li, Chuanhuo Hu Gonadotropin inhibitory hormone (GnIH) has emerged as a novel hypothalamic neuropeptide that actively inhibits gonadotropin release in birds and mammals. Recent evidence indicates that GnIH not only acts as a key neurohormone that controls vertebrate reproduction but is also involved in stress response, food intake, and aggressive and sexual behaviors, suggesting a broad physiological role for this neuropeptide. To elucidate its multiple sites of action and potential functions, studying the detai...
Source: Gene Expression Patterns - February 25, 2018 Category: Genetics & Stem Cells Source Type: research

[Non-Small Cell Lung Cancer - Development of Parallel Mechanisms of Resistance].
This report is describing the case of a patient who developed parallel two different mechanisms of resistance: A T790 M resistance mutation and a transformation into a small cell neuroendocrine cancer. Under therapy with Osimertinib and chemotherapy with carboplatin and etoposide the tumor responsed partially. PMID: 29466812 [PubMed - as supplied by publisher] (Source: Pneumologie)
Source: Pneumologie - February 24, 2018 Category: Respiratory Medicine Tags: Pneumologie Source Type: research

[Grand Duchess Alexandra Nikolajewna Romanowa].
Authors: Kropp R PMID: 29466813 [PubMed - as supplied by publisher] (Source: Pneumologie)
Source: Pneumologie - February 24, 2018 Category: Respiratory Medicine Tags: Pneumologie Source Type: research

[DGP Interstitial Lung Disease Patient Questionnaire].
CONCLUSION:  The newly developed questionnaire can facilitate the diagnosis in patients with suspicion on interstitial lung disease in clinical routine. PMID: 29466814 [PubMed - as supplied by publisher] (Source: Pneumologie)
Source: Pneumologie - February 24, 2018 Category: Respiratory Medicine Tags: Pneumologie Source Type: research

Primary pulmonary intravascular large B-cell lymphoma: A report of three cases and literature review.
Authors: Zhang Y, Bi L, Qiu Y, Zhao T, Cao M, Ding J, Meng F, Cai H Abstract The present study aimed to investigate the clinicopathological features of primary intravascular large B-cell lymphoma (IVLBCL) of the lung. The clinical and histopathological data of three patients, and the literature was reviewed. The Ethics Committees of Drum Tower Hospital approved the current study based on the three cases. Fever and respiratory symptoms were the main presenting symptoms. Serum lactate dehydrogenase and C-reactive protein were significantly increased. Diffuse ground glass opacities or nodular consolidations were seen ...
Source: Oncology Letters - February 24, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

24 – hour oxygen saturation recordings in preterm infants: editing artefact
ConclusionWe recommend that oximetry recordings to determine cardio‐respiratory stability in newborn infants ready for discharge from the neonatal unit have software editing features applied. This will remove artefact without consuming time in a busy unit.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - February 24, 2018 Category: Pediatrics Authors: Grace Wellington, Dawn Elder, Angela Campbell Tags: Regular Article Source Type: research

Hybrid Reconstruction of the Aortic Arch Using a Double-Branched Stent-Graft in a Canine Model.
CONCLUSIONS: These results demonstrate that it is possible and safe to reconstruct the aortic arch with the novel open-branched stent-graft placement. PMID: 29469632 [PubMed - as supplied by publisher] (Source: Journal of Investigative Surgery)
Source: Journal of Investigative Surgery - February 24, 2018 Category: Surgery Tags: J Invest Surg Source Type: research

Bronchial thermoplasty as a treatment for severe asthma: controversies, progress and uncertainties.
This article considers evidence for the efficacy and safety of bronchial thermoplasty from clinical trials and observational studies in clinical practice. Its place in the management of severe asthma, predictors of response and mechanisms of action are reviewed. Expert commentary: Bronchial thermoplasty improves quality of life and reduces exacerbations in moderate to severe asthma. Morbidity from asthma is increased during treatment. Overall, patients treated in clinical practice have worse baseline characteristics and comparable clinical outcomes to trial data. Follow-up studies provide reassurance on long-term safety. D...
Source: Expert Review of Respiratory Medicine - February 24, 2018 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

The Glittre-ADL Test Cut-Off Point to Discriminate Abnormal Functional Capacity in Patients with COPD.
Authors: Gulart AA, Munari AB, Klein SR, Santos da Silveira L, Mayer AF Abstract The study objective was to determine a cut-off point for the Glittre activities of daily living (ADL)test (TGlittre) to discriminate patients with normal and abnormal functional capacity. Fifty-nine patients with moderate to very severe COPD (45 males; 65 ± 8.84 years; BMI: 26 ± 4.78 kg/m2; FEV1: 35.3 ± 13.4% pred) were evaluated for spirometry, TGlittre, 6-minute walk test (6 MWT), physical ADL, modified Medical Research Council scale (mMRC), BODE index, Saint George's Respiratory Questionnaire (SGRQ), a...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 24, 2018 Category: Respiratory Medicine Tags: COPD Source Type: research

The outcomes and prognostic factors of acute respiratory failure in the patients 90 years old and over.
Authors: Chen WL, Chen CM, Kung SC, Wang CM, Lai CC, Chao CM Abstract This retrospective cohort study investigated the outcomes and prognostic factors in nonagenarians (patients 90 years old or older) with acute respiratory failure. Between 2006 and 2016, all nonagenarians with acute respiratory failure requiring invasive mechanical ventilation (MV) were enrolled. Outcomes including in-hospital mortality and ventilator dependency were measured. A total of 173 nonagenarians with acute respiratory failure were admitted to the intensive care unit (ICU). A total of 56 patients died during the hospital stay and the rate...
Source: Oncotarget - February 24, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Henoch-Sch önlein purpura in the third trimester of pregnancy.
We present the case of a 24-year-old primigravida with HSP that occurred in the third trimester and lasted up to the end of the successful delivery. She had pruritic maculopapular exanthema on her legs. Biopsy of a cutaneous lesion was performed for histopathologic features and direct immunofluorescence (DIF) for the presence of perivascular IgA deposition. Histopathology of the cutaneous lesion confirmed leukocytoclastic vasculitis. A DIF examination of the skin lesion confirmed deposits of fibrinogen in the small blood vessel walls. Six weeks following delivery, the skin lesions almost completely disappeared. Control lab...
Source: Biochemia Medica - February 24, 2018 Category: Biochemistry Tags: Biochem Med (Zagreb) Source Type: research

Errata
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Tags: ERRATA Source Type: research

A case report of hot tub lung: identical strains of Mycobacterium avium from the patient and the bathroom air
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Katsuda, Rinko Yoshida, Shiomi Tsuyuguchi, Kazunari Kawamura, Tetsuji Tags: CORRESPONDENCE Source Type: research

Molecular tests expedite the diagnosis of multidrug-resistant tuberculosis in childhood
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Namiiro, S. Wobudeya, E. Colebunders, R. Worodria, W. Tags: CORRESPONDENCE Source Type: research

Impact of switching from Caucasian to Indian reference equations for spirometry interpretation
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Chhabra, S. K. Madan, M. Tags: ORIGINAL ARTICLES Source Type: research

A rapid review of treatment literacy materials for tuberculosis patients
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Brumwell, A. Noyes, E. Kulkarni, S. Lin, V. Becerra, M. C. Yuen, C. M. Tags: ORIGINAL ARTICLES Source Type: research

Detection of tuberculosis patterns in digital photographs of chest X-ray images using Deep Learning: feasibility study
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Becker, A. S. Bl üthgen, C. Phi van, V. D. Sekaggya-Wiltshire, C. Castelnuovo, B. Kambugu, A. Fehr, J. Frauenfelder, T. Tags: ORIGINAL ARTICLES Source Type: research

The neuro-endocrine-immune relationship in pulmonary and pleural tuberculosis: a better local profile in pleural fluid
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: D ' Attilio, L. D íaz, A. Fern ández, R. D. V. Bongiovanni, B. Santucci, N. D ídoli, G. Lioi, S. Garde ñez, W. Naninni, J. L. del Rey, A. Besedovsky, H. Bottasso, O. Bay, M. L. Tags: ORIGINAL ARTICLES Source Type: research

Impact of quality improvement in tuberculosis laboratories in low- and lower-middle-income countries: a systematic review
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Olaru, I. D. Albert, H. Zallet, J. Werner, U-E. Ahmed, N. Rieder, H. L. Salfinger, M. Kranzer, K. Tags: ORIGINAL ARTICLES Source Type: research

Sputum smear-positive, culture-negative state during anti-tuberculosis treatment in the MGIT liquid culture era
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Bark, C. M. Thiel, B. A. Ogwang, S. Sekitoleko, I. Muzanyi, G. Joloba, M. L. Johnson, J. L. Tags: ORIGINAL ARTICLES Source Type: research

Prognostic factors for treatment success in patients with multidrug-resistant tuberculosis in China
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Fan, Y-M. Ding, S-P. Bao, Z-J. Wu, L-M. Zhen, L-B. Xia, Q. Zhu, M. Tags: ORIGINAL ARTICLES Source Type: research

Multidrug-resistant tuberculosis in Australia, 1998 & #8211;2012
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Francis, J. R. Manchikanti, P. Blyth, C. C. Denholm, J. Lowbridge, C. Coulter, C. Donnan, E. Stapledon, R. Krause, V. L. Waring, J. Tags: ORIGINAL ARTICLES Source Type: research

Spatial clustering of drug-resistant tuberculosis in Hlabisa subdistrict, KwaZulu-Natal, 2011 & #8211;2015
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Smith, C. M. Lessells, R. Grant, A. D. Herbst, K. Tanser, F. Tags: ORIGINAL ARTICLES Source Type: research

Delay in seeking care for tuberculosis symptoms among adults newly diagnosed with HIV in rural Malawi
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Ngwira, L. G. Dowdy, D. W. Khundi, M. Barnes, G. L. Nkhoma, A. Choko, A. T. Murowa, M. Chaisson, R. E. Corbett, E. L. Fielding, K. Tags: ORIGINAL ARTICLES Source Type: research

Completion of isoniazid preventive therapy among human immunodeficiency virus positive adults in urban Malawi
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Thindwa, D. MacPherson, P. Choko, A. T. Khundi, M. Sambakunsi, R. Ngwira, L. G. Kalua, T. Webb, E. L. Corbett, E. L. Tags: ORIGINAL ARTICLES Source Type: research

Estimating the magnitude of pulmonary tuberculosis patients missed by primary health care clinics in South Africa
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Kweza, P. F. Van Schalkwyk, C. Abraham, N. Uys, M. Claassens, M. M. Medina-Marino, A. Tags: ORIGINAL ARTICLES Source Type: research

Under-reporting of tuberculosis in Praia, Cape Verde, from 2006 to 2012
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Furtado da Luz, E. Braga, J. U. Tags: ORIGINAL ARTICLES Source Type: research

Investigating a tuberculosis cluster among Filipino health care workers in a low-incidence country
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Davidson, J. A. Fulton, N. Thomas, H. L. Lalor, M. K. Zenner, D. Brown, T. Murphy, S. Anderson, L. F. Tags: ORIGINAL ARTICLES Source Type: research

Prevalence of latent tuberculous infection among adults in the general population of Ca Mau, Viet Nam
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Marks, G. B. Nhung, N. V. Nguyen, T. A. Hoa, N. B. Khoa, T. H. Son, N. V. Phuong, N. T. B. Tin, D. M. Ho, J. Fox, G. J. Tags: ORIGINAL ARTICLES Source Type: research

Principles for constructing a tuberculosis treatment regimen: the role and definition of core and companion drugs
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Van Deun, A. Decroo, T. Piubello, A. de Jong, B. C. Lynen, L. Rieder, H. L. Tags: PERSPECTIVES Source Type: research

Towards patient-centred care: analysing TB treatment literacy documents and adherence discourses
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 24, 2018 Category: Respiratory Medicine Authors: Engel, Nora Tags: EDITORIALS Source Type: research

Editorial Board
(Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 24, 2018 Category: Respiratory Medicine Source Type: research

Parent emotion regulation socializes children's adaptive physiological regulation
This study examined whether parents’ physiological and emotion regulation abilities corresponded to children's physiological and emotional responding to a structured laboratory‐based disappointment task. Ninety‐seven 3‐ to 7‐year‐olds (56 girls; M = 5.79 years) and one parent participated in a multi‐method assessment of parents’ and children's regulatory functioning. Direct (coaching children to use reappraisal) and indirect (resting physiology, dispositional use of reappraisal) aspects of parents’ regulatory abilities were assessed. As expected, an adaptive pattern of parent reg...
Source: Developmental Psychobiology - February 24, 2018 Category: Psychiatry & Psychology Authors: Emily W. Shih, Laura E. Qui ñones‐Camacho, Elizabeth L. Davis Tags: BRIEF REPORT Source Type: research

High Serum Bilirubin Levels, NT-pro-BNP, and Lactate Predict Mortality in Long-Term, Severely Ill Respiratory ECMO Patients
Mortality in patients treated with extracorporeal membrane oxygenation (ECMO) is high. Therefore, it is crucial to better understand conditions that are associated with mortality in ECMO patients. In this retrospective analysis, we observed 51 patients treated with high-flow ECMO in 2013 and 2014 at our center. We recorded laboratory values and intensive care procedures. The hypothesis of bilirubin being a predictor of mortality during ECMO treatment was initially addressed. Therefore, laboratory values were obtained before initiation and at the time of highest bilirubin throughout the procedure. Receiver operating charact...
Source: ASAIO Journal - February 24, 2018 Category: Medical Devices Tags: Clinical Critical Care Source Type: research

Nongonococcal and Nonmeningococcal Neisseria Infection in Patients With Cancer
We report a case series of nongonococcal and nonmeningococcal Neisseria infection in patients with underlying malignancy to add to this limited body of knowledge and to provide further evidence of the opportunistic potential of these species in immune-compromised hosts. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - February 24, 2018 Category: Infectious Diseases Tags: Original Articles Source Type: research

Mycobacterium tuberculosis Diversity by Exact Tandem Repeats-Variable Number Tandem Repeat Method in Azerbaijan, Iran
Conclusions Thirty-three distinct patterns were distinguished. In the case of respiratory symptoms in patients with diabetes and close household contact patients, TB can be considered as the important differential diagnosis with unique patterns. (Source: Infectious Diseases in Clinical Practice)
Source: Infectious Diseases in Clinical Practice - February 24, 2018 Category: Infectious Diseases Tags: Original Articles Source Type: research

Mitochondrial Respiratory Chain Complexes.
Abstract Mitochondria are the power stations of the eukaryotic cell, using the energy released by the oxidation of glucose and other sugars to produce ATP. Electrons are transferred from NADH, produced in the citric acid cycle in the mitochondrial matrix, to oxygen by a series of large protein complexes in the inner mitochondrial membrane, which create a transmembrane electrochemical gradient by pumping protons across the membrane. The flow of protons back into the matrix via a proton channel in the ATP synthase leads to conformational changes in the nucleotide binding pockets and the formation of ATP. The three p...
Source: Sub-Cellular Biochemistry - February 24, 2018 Category: Biochemistry Authors: Sousa JS, D'Imprima E, Vonck J Tags: Subcell Biochem Source Type: research

Cystic fibrosis epithelial cells are primed for apoptosis as a result of increased Fas (CD95)
Previous work suggests that apoptosis is dysfunctional in cystic fibrosis (CF) airways with conflicting results. We evaluated the relationship between dysfunctional cystic fibrosis transmembrane conductance regulator (CFTR) and apoptosis in CF airway epithelial cells. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 24, 2018 Category: Respiratory Medicine Authors: Qiwei Chen, Sudha Priya Soundara Pandi, Lauren Kerrigan, Noel G. McElvaney, Catherine M. Greene, J. Stuart Elborn, Clifford C. Taggart, Sin éad Weldon Tags: Original Article Source Type: research

Malignant mesothelioma presenting as recurrent hydro-pneumothorax: An atypical case presentation and literature review
We present the case of 79-year-old male smoker with no documented history of asbestos exposure, who was found to have MPM after presenting with dyspnea and subsequently found to have recurrent hydro-pneumothorax. On Literature review of the limited documented cases of MPM with hydro-pneumothorax, we found an exclusively male population with a significant smoking history, a marked right sided pathology predominance, and a generally poor prognosis. While this corresponds with the examined case, and suggests that the presence of hydro-pneumothorax implies a high-grade tumor and significant tissue invasion, and therefore poor ...
Source: Respiratory Medicine Case Reports - February 24, 2018 Category: Respiratory Medicine Source Type: research

A review of the etiology and clinical presentation of non-cystic fibrosis bronchiectasis: A tertiary care experience
Non-cystic fibrosis(CF) bronchiectasis has been recognized in children for the past 200 years. Early childhood pneumonia and underlying conditions such as immunodeficiency, primary ciliary dyskinesia(PCD), and congenital lung pathology should be considered in the etiology. The aim of our study was to describe the clinical characteristics, laboratory, and radiological findings of a large population of patients with non-CF bronchiectasis at a tertiary center. (Source: Respiratory Medicine)
Source: Respiratory Medicine - February 24, 2018 Category: Respiratory Medicine Authors: Ozlem Sat ırer, Ayse Mete Yesil, Nagehan Emiralioglu, Gökcen Dilsa Tugcu, Ebru Yalcın, Deniz Dogru, Nural Kiper, Ugur Ozcelik Source Type: research

Mechanisms to Evade the Phagocyte Respiratory Burst Arose by Convergent Evolution in Typhoidal Salmonella Serovars
Publication date: 13 February 2018 Source:Cell Reports, Volume 22, Issue 7 Author(s): Hirotaka Hiyoshi, Tamding Wangdi, Gabriel Lock, Cheng Saechao, Manuela Raffatellu, Brian A. Cobb, Andreas J. Bäumler Typhoid fever caused by Salmonella enterica serovar (S.) Typhi differs in its clinical presentation from gastroenteritis caused by S. Typhimurium and other non-typhoidal Salmonella serovars. The different clinical presentations are attributed in part to the virulence-associated capsular polysaccharide (Vi antigen) of S. Typhi, which prevents phagocytes from triggering a respiratory burst by preventing antibody-mediate...
Source: Cell Reports - February 24, 2018 Category: Cytology Source Type: research

Kinetics and Mechanism of Mammalian Mitochondrial Ribosome Assembly
Publication date: 13 February 2018 Source:Cell Reports, Volume 22, Issue 7 Author(s): Daniel F. Bogenhagen, Anne G. Ostermeyer-Fay, John D. Haley, Miguel Garcia-Diaz Mammalian mtDNA encodes only 13 proteins, all essential components of respiratory complexes, synthesized by mitochondrial ribosomes. Mitoribosomes contain greatly truncated RNAs transcribed from mtDNA, including a structural tRNA in place of 5S RNA as a scaffold for binding 82 nucleus-encoded proteins, mitoribosomal proteins (MRPs). Cryoelectron microscopy (cryo-EM) studies have determined the structure of the mitoribosome, but its mechanism of assembly is un...
Source: Cell Reports - February 24, 2018 Category: Cytology Source Type: research

An experimental and computational study of the inferior vena cava hemodynamics under respiratory-induced collapse of the infrarenal IVC
Pulmonary embolism (PE) is the third most common cause of death from cardiovascular disease, after heart attack and stroke [1]. Usually associated with deep vein thrombosis (DVT), pulmonary embolism occurs when a venous thrombus embolizes and passes through the inferior vena cava (IVC) to the pulmonary arteries. Emboli occluding blood flow to one or both lungs can lead to impaired oxygenation, heart strain, and death [2]. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - February 24, 2018 Category: Biomedical Engineering Authors: Elisabetta Tedaldi, Chiara Montanari, Kenneth I. Aycock, Francesco Sturla, Alberto Redaelli, Keefe B. Manning Source Type: research

A flow-leak correction algorithm for pneumotachographic work-of-breathing measurement during high-flow nasal cannula oxygen therapy
High-flow oxygen therapy through a nasal cannula (HFNC) is increasingly used as a technique for treating respiratory failure [1]. Delivery of a heated and humidified oxygen/air mixture at high flow rates improves ventilatory efficiency and generates a positive pharyngeal pressure that reduces the work of breathing (WOB) [2]. In current practice, HFNC therapy is initiated at a flow rate of 1  L/kg/min + 1 and flow is then titrated according to respiratory distress [3]. Whether this procedure does so safely nevertheless remains uncertain, because subsequent variations in flow settings fail to take into account effectiv...
Source: Medical Engineering and Physics - February 24, 2018 Category: Biomedical Engineering Authors: Francesco Montecchia, Fabio Midulla, Paola Papoff Source Type: research

Low pathogenic avian influenza virus infection increases the staining intensity of KUL01+ cells including macrophages yet decrease of the staining intensity of KUL01+ cells using clodronate liposomes did not affect the viral genome loads in chickens
This study indicates that although KUL01+ cell intensity are increased in respiratory and gastrointestinal tissues in chickens following H4N6 LPAIV infection, the decrease of KUL01+ cell intensity using clodronate liposomes did not change the H4N6 LPAIV genome loads in any of the examined tissues suggesting that KUL01+ cells may not be critical during H4N6 LPAIV infection in chicken. (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - February 24, 2018 Category: Veterinary Research Source Type: research

Maturation of the Coordination Between Respiration and Deglutition with and Without Recurrent Laryngeal Nerve Lesion in an Animal Model
AbstractThe timing of the occurrence of a swallow in a respiratory cycle is critical for safe swallowing, and changes with infant development. Infants with damage to the recurrent laryngeal nerve, which receives sensory information from the larynx and supplies the intrinsic muscles of the larynx, experience a significant incidence of dysphagia. Using our validated infant pig model, we determined the interaction between this nerve damage and the coordination between respiration and swallowing during postnatal development. We recorded 23 infant pigs at two ages (neonatal and older, pre-weaning) feeding on milk with barium us...
Source: Dysphagia - February 24, 2018 Category: Speech-Language Pathology Source Type: research