Log in to search using one of your social media accounts:

[Role of vaccination after COPD exacerbation].
Authors: Revest M, Tattevin P PMID: 28526510 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 22, 2017 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Prognostic Indicators of Response to Plasmapheresis in Patients of Guillain Barre Syndrome.
CONCLUSIONS: Early treatment with plasmapheresis has better outcome in patients of GBS.four and five cycles of plasmapheresis are equally beneficial. PMID: 28527161 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - May 22, 2017 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Rare Cause of Type 2 Respiratory Failure: Arnold Chiari Malformation.
Authors: Bhushan D PMID: 28527177 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - May 22, 2017 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

[Functional respiratory imaging after neostigmine- or sugammadex-enhanced recovery from neuromuscular blockade in the anesthetised rat: a randomised controlled pilot study].
CONCLUSION: This pilot study in rats demonstrated an increased relative contribution of chest wall expansion after neostigmine compared with sugammadex or saline. This smaller relative contribution of diaphragm movement may be explained by a neostigmine-induced decrease in phrenic nerve activity or by remaining occupied acetylcholine receptors after neostigmine. PMID: 28526472 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Anestesiologia)
Source: Revista Brasileira de Anestesiologia - May 22, 2017 Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research

Effect of expiratory muscle strength training intervention on the maximum expiratory pressure and quality of life of patients with Parkinson disease.
CONCLUSION: Both 5 d/wk and 3 d/wk of EMST effectively enhance respiratory muscle strength and improve mobility construct measured by PDQ-39 in patients with PD. PMID: 28527233 [PubMed - as supplied by publisher] (Source: NeuroRehabilitation)
Source: NeuroRehabilitation - May 22, 2017 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

Serum periostin relates to type ‐2 inflammation and lung function in asthma: Data from the large population‐based cohort Swedish GA(2)LEN
ConclusionWe confirm associations between periostin and markers of type 2 inflammation, as well as lung function, and identify novel constitutional factors of importance to the use of periostin as a phenotype‐specific biomarker in asthma. (Source: Allergy)
Source: Allergy - May 22, 2017 Category: Allergy & Immunology Authors: A. James, C. Janson, A. Malinovschi, C. Holweg, K. Alving, J. Ono, S. Ohta, A. Ek, R. Middelveld, B. Dahl én, B. Forsberg, K. Izuhara, S.‐E. Dahlén Tags: ORIGINAL ARTICLE Source Type: research

Silver nanoparticles: Antimicrobial activity, cytotoxicity, and synergism with N ‐acetyl cysteine
The fast progression of nanotechnology has led to novel therapeutic interventions. Antimicrobial activities of silver nanoparticles (Ag NPs) were tested against standard ATCC strains of Staphylococcus aureus (ATCC 9144), Escherichia coli (O157:H7), Pseudomonas aeruginosa (ATCC 27853), and Candida albicans (ATCC 90028) in addition to 60 clinical isolates collected from cancer patients. Antimicrobial activity was tested by disk diffusion method and MIC values for Ag NPs alone and in combination with N‐acetylcysteine (NAC) against tested pathogens were determined by broth microdilution method. Ag NPs showed a robust antimic...
Source: Journal of Basic Microbiology - May 22, 2017 Category: Microbiology Authors: Selwan Hamed, Mohamed Emara, Riham M. Shawky, Ramadan A. El ‐domany, Tareq Youssef Tags: RESEARCH PAPER Source Type: research

Redox signaling in acute oxygen sensing
Publication date: August 2017 Source:Redox Biology, Volume 12 Author(s): Lin Gao, Patricia González-Rodríguez, Patricia Ortega-Sáenz, José López-Barneo Acute oxygen (O2) sensing is essential for individuals to survive under hypoxic conditions. The carotid body (CB) is the main peripheral chemoreceptor, which contains excitable and O2-sensitive glomus cells with O2-regulated ion channels. Upon exposure to acute hypoxia, inhibition of K+ channels is the signal that triggers cell depolarization, transmitter release and activation of sensory fibers that stimulate the brainstem respiratory center to produce hyperventilati...
Source: Redox Biology - May 22, 2017 Category: Biology Source Type: research

Metabolic Alterations at the Crossroad of Aging and Oncogenesis.
Abstract Aging represents the major risk factor for cancer. Cancer and aging are characterized by a similar dysregulated metabolism consisting in upregulation of glycolysis and downmodulation of oxidative phosphorylation. In this respect, metabolic interventions can be viewed as promising strategies to promote longevity and to prevent or delay age-related disorders including cancer. In this review, we discuss the most promising metabolic approaches including chronic calorie restriction, periodic fasting/fasting-mimicking diets, and pharmacological interventions mimicking calorie restriction. Metabolic intervention...
Source: International Review of Cell and Molecular Biology - May 21, 2017 Category: Cytology Authors: Raffaghello L, Longo V Tags: Int Rev Cell Mol Biol Source Type: research

[PPerformance of LED fluorescence microscopy for the detection of acid-fast bacilli from respiratory samples in peripheral laboratories in Argentina].
CONCLUSION: LED-FM better performance compared with ZN in HIV-infected patients and user-appraisal support the rapid roll-out of LED-FM. Screening at 200x magnification was essential to achieve LEDFM increased sensitivity. PMID: 28527280 [PubMed - in process] (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - May 21, 2017 Category: International Medicine & Public Health Tags: Biomedica Source Type: research

Roles of roflumilast, a selective phosphodiesterase 4 inhibitor, in airway diseases.
Authors: Kawamatawong T Abstract Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases. Both diseases have incompletely distinct pathophysiology, clinical manifestation, and treatment responsiveness. Pulmonary and systemic inflammations are the hallmarks of COPD. Most asthma responds to inhaled corticosteroid (ICS) treatment. In contrast, COPD is a corticosteroid-resistant disease. Bronchodilators are a preferred treatment method of COPD, with the aim of improving symptoms and preventing exacerbation. In addition, corticosteroid insensitivity is an underlying mechanism in s...
Source: Journal of Thoracic Disease - May 21, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

A case of video-assisted thoracoscopic resection of malignant transformation of pulmonary recurrent respiratory papillomatosis.
We report the case of a patient with unmonitored juvenile onset RRP with pulmonary involvement found to have malignant transformation to squamous cell carcinoma (SCC). Incidentally found on chest radiography for mild chest wall trauma, she was found to have a large left lower lobe mass with pathology consistent with SCC. The patient underwent surgical management with thoracoscopic left lower lobectomy and mediastinal lymph node dissection followed by adjuvant chemoradiation for pathologic stage IIIA SCC. Surveillance imaging at 6 months shows no evidence of disease progression. PMID: 28523179 [PubMed - in process] (Sou...
Source: Journal of Thoracic Disease - May 21, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Phenotypic presentation of chronic cough in children.
Authors: Kantar A Abstract Chronic cough in children is increasingly defined as a cough that lasts more than four weeks. It is recognized as a different entity than cough in adults. As a result, the diagnostic approach and management of chronic cough in children are no longer extrapolated from adult guidelines. These differences are attributed to the various characteristics of the respiratory tract, immunological system and nervous system in children. Specific paediatric guidelines and algorithms for chronic cough are now widely applied. Post-infectious cough, asthma, bronchiectasis, malacia and protracted bacteria...
Source: Journal of Thoracic Disease - May 21, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Respiratory bronchiolitis-associated interstitial lung disease - an unexpected form of idiopathic interstitial pneumonia in a young male.
We report a case of a young male, who complained of respiratory symptoms, had normal volumes and flows on lung function tests, moderately reduced transfer factor for carbon monoxide and "ground glass" attenuation on high-resolution computed tomography. Because the patient had exposure to contact with parrots, hypersensitivity pneumonitis was considered, but the broncho-alveolar lavage was without lymphocytosis. Open lung biopsy confirmed the diagnosis of respiratory bronchiolitis-associated interstitial lung disease, a rarely described entity in the medical literature. The patient had a good clinical outcome after smoking ...
Source: Romanian Journal of Morphology and Embryology - May 21, 2017 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Apert syndrome - clinical case.
We present here the case of a newborn with Apert syndrome that was born prematurely in our Clinic after a monitored pregnancy, where there was issued a suspicion of cranio-facial dysmorphism, malposition and malformation of the feet and hands in the third quarter of prenatal pregnancy. The diagnosis of Apert syndrome was placed on clinical signs, laboratory and genetic tests. The clinical outcome of the baby in the maternity was favorable, the therapeutic management being established by a multidisciplinary team. Immediate complications were due to the case of prematurity: respiratory distress syndrome and the characteristi...
Source: Romanian Journal of Morphology and Embryology - May 21, 2017 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research

Protective Effects of Hydrogen-Rich Saline Against Lipopolysaccharide-Induced Alveolar Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis.
CONCLUSIONS Hydrogen-rich saline may protect against LPS-induced EMT and pulmonary fibrosis through suppressing oxidative stress. PMID: 28522797 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 21, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Genetic variability of the S1 subunit of enteric and respiratory bovine coronavirus isolates.
Abstract Bovine coronavirus (BCoV) is considered an important pathogen in cattle worldwide. It is a causative agent of enteric and respiratory diseases of cattle. The S1 subunit of the viral S glycoprotein is responsible for virus binding to host-cell receptors, induction of neutralizing antibody and hemagglutinin activity. The entire S1 genomic region (2304 bp) of two enteric bovine coronavirus isolates from Austria, one respiratory and one enteric isolate from Slovakia were analyzed at the genetic level. The comparative analysis of those four isolates revealed 97.1-98.6% similarity at the nucleotide and 95.6-98....
Source: Acta Virologica - May 21, 2017 Category: Infectious Diseases Authors: Vilček S, Jacková A, Kolesárová M, Vlasáková M Tags: Acta Virol Source Type: research

Relationship between quantitative and descriptive methods of studying blood flow through intrapulmonary arteriovenous anastomoses during exercise
Publication date: Available online 20 May 2017 Source:Respiratory Physiology & Neurobiology Author(s): Joseph W. Duke, Jonathan E. Elliott, Steven S. Laurie, Thomas Voelkel, Igor M. Gladstone, Mathews B. Fish, Andrew T. Lovering Several methods exist to study intrapulmonary arteriovenous anastomoses (IPAVA) in humans. Transthoracic saline contrast echocardiography (TTSCE), i.e., bubble scores, is minimally-invasive, but cannot be used to quantify the magnitude of blood flow through IPAVA (QIPAVA). Radiolabeled macroaggregates of albumin (99mTc-MAA) have been used to quantify QIPAVA in humans, but this requires inj...
Source: Respiratory Physiology and Neurobiology - May 21, 2017 Category: Respiratory Medicine Source Type: research

Home Noninvasive Ventilation to Reduce Readmissions for COPD
The use of long-term noninvasive ventilation (NIV) to benefit patients with severe chronic obstructive pulmonary disease (COPD) has long been controversial. Dating back to the 1960s, clinicians speculated that intermittent respiratory muscle rest afforded by negative pressure ventilators might benefit daytime respiratory muscle performance of patients with severe COPD. However, use of this approach was generally abandoned in the early 1990s when a large randomized clinical trial using a “jacket” negative pressure ventilator nocturnally showed no improvement in exercise endurance or respiratory muscle strength in patien...
Source: JAMA - Journal of the American Medical Association - May 21, 2017 Category: General Medicine Source Type: research

Molecular approaches to the diagnosis and monitoring of production diseases in pigs
Publication date: October 2017 Source:Research in Veterinary Science, Volume 114 Author(s): Timothy A. Giles, Aouatif Belkhiri, Paul A. Barrow, Neil Foster Production disease in pigs is caused by a variety of different pathogens, mainly enteric and respiratory and can result in significant economic loss. Other factors such as stress, poor husbandry and nutrition can also contribute to an animal's susceptibility to disease. Molecular biomarkers of production disease could be of immense value by improving diagnosis and risk analysis to determine best practice with an impact on increased economic output and animal welfare. I...
Source: Research in Veterinary Science - May 21, 2017 Category: Veterinary Research Source Type: research

Bedaquiline-based treatment regimen for multidrug-resistant tuberculosis
Treatment outcomes for multidrug-resistant (MDR) tuberculosis (TB) are poor with only approximately 50% of patients attaining treatment success [1]. An important driver of treatment failure in many settings is the unavailability of effective drugs for MDR- and extensively drug-resistant (XDR)-TB. (Source: European Respiratory Journal)
Source: European Respiratory Journal - May 21, 2017 Category: Respiratory Medicine Authors: Olaru, I. D., Heyckendorf, J., Andres, S., Kalsdorf, B., Lange, C. Tags: Respiratory infections and tuberculosis Original Articles: Research letters Source Type: research

Bedaquiline for the treatment of multidrug-resistant tuberculosis: another missed opportunity?
5 years after its first approval by a stringent regulatory authority, the role of bedaquiline in the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) is well established, and acknowledged by existing guidance. However, in many regards, the global introduction of bedaquiline can hardly be considered as a success. (Source: European Respiratory Journal)
Source: European Respiratory Journal - May 21, 2017 Category: Respiratory Medicine Authors: Guglielmetti, L. Tags: Respiratory infections and tuberculosis Editorials Source Type: research

Effectiveness and safety of bedaquiline-containing regimens in the treatment of MDR- and XDR-TB: a multicentre study
This study aimed to evaluate the safety and effectiveness of bedaquiline-containing regimens in a large, retrospective, observational study conducted in 25 centres and 15 countries in five continents. 428 culture-confirmed MDR-TB cases were analysed (61.5% male; 22.1% HIV-positive, 45.6% XDR-TB). MDR-TB cases were admitted to hospital for a median (interquartile range (IQR)) 179 (92–280) days and exposed to bedaquiline for 168 (86–180) days. Treatment regimens included, among others, linezolid, moxifloxacin, clofazimine and carbapenems (82.0%, 58.4%, 52.6% and 15.3% of cases, respectively). Sputum smear and cul...
Source: European Respiratory Journal - May 21, 2017 Category: Respiratory Medicine Authors: Borisov, S. E., Dheda, K., Enwerem, M., Romero Leyet, R., D'Ambrosio, L., Centis, R., Sotgiu, G., Tiberi, S., Alffenaar, J.-W., Maryandyshev, A., Belilovski, E., Ganatra, S., Skrahina, A., Akkerman, O., Aleksa, A., Amale, R., Artsukevich, J., Bruchfeld, J Tags: Respiratory infections and tuberculosis Original Articles: Tuberculosis Source Type: research

The long and winding road of chest radiography for tuberculosis detection
The aspiration to ensure early diagnosis for all people with tuberculosis (TB) [1], combined with recent advancements in digital technology, has brought chest radiography back to the forefront for TB detection. Once a mainstay for TB control in the community, but discouraged once bacteriology became the standard for TB diagnosis, chest radiography has recently come back into favour for its ability to detect TB early, often before the onset of clear symptoms. In addition, the advent of digital radiography has improved the quality and safety of the procedure and has led to possibilities such as telemedicine and computer-aide...
Source: European Respiratory Journal - May 21, 2017 Category: Respiratory Medicine Authors: Miller, C., Lonnroth, K., Sotgiu, G., Migliori, G. B. Tags: Respiratory infections and tuberculosis Editorials Source Type: research

Bedaquiline as a potential agent in the treatment of Mycobacterium abscessus infections
Mycobacterium abscessus is increasingly being recognised as a significant human pathogen, especially in patients with cystic fibrosis, and the specific M. abscessus subspecies seems to influence the clinical outcome [1]. The pulmonary manifestation of this nontuberculous mycobacteria (NTM) infection is one of the most difficult to treat forms, leading to substantial morbidity and mortality in this population [1, 2]. M. abscessus strains are highly resistant to most antibacterial drugs [2]. The recent development of liposomal amikacin for inhalation for patients with cystic fibrosis suggested a therapeutic breakthrough. How...
Source: European Respiratory Journal - May 21, 2017 Category: Respiratory Medicine Authors: Vesenbeckh, S., Schönfeld, N., Roth, A., Bettermann, G., Krieger, D., Bauer, T. T., Rüssmann, H., Mauch, H. Tags: Respiratory infections and tuberculosis Original Articles: Research letters Source Type: research

An evaluation of automated chest radiography reading software for tuberculosis screening among public- and private-sector patients
Computer-aided reading (CAR) of medical images is becoming increasingly common, but few studies exist for CAR in tuberculosis (TB). We designed a prospective study evaluating CAR for chest radiography (CXR) as a triage tool before Xpert MTB/RIF (Xpert). Consecutively enrolled adults in Dhaka, Bangladesh, with TB symptoms received CXR and Xpert. Each image was scored by CAR and graded by a radiologist. We compared CAR with the radiologist for sensitivity and specificity, area under the receiver operating characteristic curve (AUC), and calculated the potential Xpert tests saved. A total of 18 036 individuals were enrolled. ...
Source: European Respiratory Journal - May 21, 2017 Category: Respiratory Medicine Authors: Rahman, M. T., Codlin, A. J., Rahman, M. M., Nahar, A., Reja, M., Islam, T., Qin, Z. Z., Khan, M. A. S., Banu, S., Creswell, J. Tags: Respiratory infections and tuberculosis Original Articles: Tuberculosis Source Type: research

[Criteria for hospital discharge  after COPD exacerbation].
[Criteria for hospital discharge after COPD exacerbation]. Rev Mal Respir. 2017 May 15;: Authors: Dres M PMID: 28522148 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - May 20, 2017 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Rising utilization of inpatient pediatric asthma pathways.
CONCLUSIONS: From 2005-2015, there was a dramatic rise in implementation of inpatient pediatric asthma pathways. We found variation in many aspects of pathway design and implementation. Future studies should determine optimal implementation strategies to better support hospital-level efforts in improving pediatric asthma care and outcomes. PMID: 28521558 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 20, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Pharmacokinetic/pharmacodynamic evaluation of marbofloxacin as a single injection for Pasteurellaceae respiratory infections in cattle using population pharmacokinetics and Monte Carlo simulations
Population pharmacokinetic of marbofloxacin was investigated with 52 plasma concentration–time profiles obtained after intramuscular administration of Forcyl® in cattle. Animal's status, pre‐ruminant, ruminant, or dairy cow, was retained as a relevant covariate for clearance. Monte Carlo simulations were performed using a stratification by status, and 1000 virtual disposition curves were generated in each bovine subpopulation for the recommended dosage regimen of 10 mg/kg as a single injection. The probability of target attainment (PTA) of pharmacokinetic/pharmacodynamic (PK/PD) ratios associated with clinical effica...
Source: Journal of Veterinary Pharmacology and Therapeutics - May 20, 2017 Category: Veterinary Research Authors: A. Paulin, M. Schneider, F. Dron, F. Woehrle Tags: ORIGINAL ARTICLE Source Type: research

Interstitial lung disease is associated to infections of lower respiratory tract in immunocompromised rheumatoid arthritis patients.
Authors: Sebastiani M, Manfredi A, Cassone G, Sandri G, Cerri S, Ferri C Abstract ****************************************************************************. PMID: 28516882 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - May 20, 2017 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Frequency of untreated hypogammaglobulinemia in bronchiectasis
Bronchiectasis is found in approximately one fourth of patients with common variable immune deficiency, with 14% in 1 study having bronchiectasis at the time of diagnosis,1 and lower respiratory tract symptoms are associated with a lower quality of life and require increased immunoglobulin (Ig) usage.2,3 Additional primary immune deficiencies also are associated with a high rate of bronchiectasis, including IgA deficiency, IgG subclass deficiency, and specific antibody deficiency against polysaccharide antigen despite normal levels  of quantitative immunoglobulins. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - May 20, 2017 Category: Allergy & Immunology Authors: Melanie A. Ruffner, Timothy R. Aksamit, Byron Thomashow, Radmila Choate, Angela DiMango, Gerard M. Turino, Anne E. O'Donnell, Margaret M. Johnson, Kenneth N. Olivier, Kevin Fennelly, Charles L. Daley, Kevin L. Winthrop, Mark L. Metersky, Matthias A. Salat Tags: Letter Source Type: research

Multi-resolution classification of exhaled aerosol images to detect obstructive lung diseases in small airways
The objective of this study is to develop a simulation-based classification model that can accurately classify small airway diseases. The model performance was evaluated in five obstructed models that are located in lung bifurcations G7-9. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - May 20, 2017 Category: Bioinformatics Authors: Jinxiang Xi, Weizhong Zhao, Jiayao Eddie Yuan, Biwei Cao, Linlin Zhao Source Type: research

Respiratory severity score and extubation readiness in very low birth weight infants
The respiratory severity score (RSS) is a byproduct of mean airway pressure (MAP) and fraction of inspired oxygen (FiO2). We sought to determine whether RSS could be used as a screening tool to predict extubation readiness in very low birth weight (VLBW) infants. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - May 20, 2017 Category: Perinatology & Neonatology Authors: Maroun J. Mhanna, Narayan P. Iyer, Scott Piraino, Mohit Jain Tags: Original Article Source Type: research

Inhaled ENaC antisense oligonucleotide ameliorates cystic fibrosis-like lung disease in mice
Epithelial sodium channel (ENaC, Scnn1) hyperactivity in the lung leads to airway surface dehydration and mucus accumulation in cystic fibrosis (CF) patients and in mice with CF-like lung disease. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - May 20, 2017 Category: Respiratory Medicine Authors: Jeff R. Crosby, Chenguang Zhao, Chong Jiang, Dong Bai, Melanie Katz, Sarah Greenlee, Hiroshi Kawabe, Michael McCaleb, Daniela Rotin, Shuling Guo, Brett P. Monia Tags: Original Article Source Type: research

Fungal Infections After Lung Transplantation
Infection remains a significant source of morbidity and mortality after lung transplant, including fungal infection. Various antifungal prophylaxis agents are administered for a variable duration after transplant with the goal of preventing invasive fungal infections. Alternatively, some programs target the use of antifungal agents only in those colonized with Aspergillus species. Despite prophylaxis or pre-emptive therapy, a significant number of invasive fungal infections occur after lung transplant. Risk factors for fungal infections include single lung transplant, pretransplant Aspergillus colonization, environmental r...
Source: Clinics in Chest Medicine - May 20, 2017 Category: Respiratory Medicine Authors: Cassie C. Kennedy, Raymund R. Razonable Source Type: research

Streptococcus pneumoniae Otitis Media Pathogenesis and How It Informs Our Understanding of Vaccine Strategies
This study aimed to review the literature regarding the mechanisms of transition from asymptomatic colonization to induction of otitis media and how the insight into the pathogenesis of otitis media has the potential to help design future otitis media-directed vaccines.Recent FindingsRespiratory viruses have long been shown to predispose individuals to bacterial respiratory infections, such as otitis media. Recent information suggests thatStreptococcus pneumoniae, which colonize the nasopharynx asymptomatically, can sense potentially “threatening” changes in the nasopharyngeal environment caused by virus infection by u...
Source: Current Otorhinolaryngology Reports - May 20, 2017 Category: ENT & OMF Source Type: research

Budesonide, fluticasone propionate, and azithromycin do not modulate the membrane vesicle release by THP-1 macrophages and respiratory pathogens during macrophage infection
In this study, we determined the effect of several pharmacological agents on  MVs release by and bacterial growth of common respiratory pathogens. We found that neither the release of MVs nor the bacterial growth was affected by the glucocorticoids budesonide and fluticasone. The macrolide antibiotic azithromycin only inhibited the growth ofMoraxella catarrhalis but no effects were observed on bacterial MV release at a concentration that is achieved locally in the epithelial lining on administration. The macrophage pro-inflammatory response to MVs was significantly reduced after treatment with budesonide and fluticasone b...
Source: Inflammopharmacology - May 20, 2017 Category: Drugs & Pharmacology Source Type: research

Cardio respiratory response: Validation of new modifications of bruce protocol for exercise testing and training in elite saudi triathlon and soccer players
Conclusions,Clinical Relevance It is often difficult to achieve a high cardiorespiratory response, VO2max, without an association to high values of HR max, and peak perceived exertion. This may lead to cardiovascular risk. Our new modifications can provide a practical, valid alternative protocol to be used comfortably both during exercise testing and training, rather than performance testing only, to achieve high VO2max with minimal cardiovascular stress. (Source: Saudi Journal of Biological Sciences)
Source: Saudi Journal of Biological Sciences - May 20, 2017 Category: Biology Source Type: research

In  vitro effects of Italian Lavandula multifida L. leaf extracts on gilthead seabream (Sparus aurata) leucocytes and SAF-1 cells
Publication date: July 2017 Source:Fish & Shellfish Immunology, Volume 66 Author(s): Angela Fazio, Rebeca Cerezuela, Maria Rosaria Panuccio, Alberto Cuesta, Maria Ángeles Esteban Lavandula multifida is very appreciated by pharmaceutical and cosmetic industries. In Italy is only found in Calabria and Sicily and, at present, urge its valorization due to its high extinction and genetic erosion risks. Possible applications of L. multifida extracts as immunostimulant in fish aquaculture were assayed by using gilthead seabream (Sparus aurata) as a marine fish model, due to its importance in fish aquaculture. The in v...
Source: Fish and Shellfish Immunology - May 20, 2017 Category: Biology Source Type: research

Analysis of the patients with simultaneous bilateral spontaneous pneumothorax
Conclusion: These results suggest that simultaneous and bilateral occurrence of SPP is an indicator of an advanced lung pathology with a poor prognosis. This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - May 20, 2017 Category: Respiratory Medicine Authors: Tevfik Ilker Akcam, Onder Kavurmaci, Ayse Gul Ergonul, Sercan Aydin, Kutsal Turhan, Alpaslan Cakan, Ufuk Cagirici Tags: Original Article Source Type: research

Lecznicze zastosowanie mieszanek mlekozast ępczych w alergii na białka mleka krowiego oraz alergii wielopokarmowej w wieku rozwojowym
Publication date: Available online 19 May 2017 Source:Pediatria Polska Author(s): Maciej Kaczmarski Cow's milk protein allergy (CMPA) may affect between 2,0–3,0 percent of infants and young children. Milk proteins may induce allergic reactions and are responsible for a variety of clinical symptoms, involving mainly the skin, gastrointestinal and respiratory tracts. The general symptoms such as anaphylaxis are rarely occurring. These CMPA symptoms are easily missed in primary care settings; therefore, the proper knowledge on clinical symptoms, accurate diagnosis and management are desirable. This paper discusses mostly t...
Source: Pediatria Polska - May 20, 2017 Category: Pediatrics Source Type: research

Evaluation of Respiratory Protection Program in Petrochemical Industries; Application of Analytic Hierarchy Process (AHP)
Conclusion None of under studied petrochemical industries implemented respiratory protection program completely. This can lead to employees’ over exposure to hazardous workplace air contaminants. Increasing awareness through training to employees and employers were suggested by this study to improve such conditions. (Source: Safety and Health at Work)
Source: Safety and Health at Work - May 20, 2017 Category: Occupational Health Source Type: research

Unilateral nasal obstruction induces degeneration of fungiform and circumvallate papillae in rats
Conclusions Findings in the present study suggest that nasal obstruction might have significant influences on the gustatory function via morphologic change in the taste papillae and taste buds in tongue area. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - May 20, 2017 Category: General Medicine Source Type: research

Diagnosis of morbid obesity may not impact healthcare utilization for orthotopic liver transplantation: A propensity matched study.
CONCLUSION: Morbid obesity may not impact in-hospital mortality and health care utilization in OLT recipients. However, morbidly obese patients may be selected after careful assessment of co-morbidities. PMID: 28515845 [PubMed - in process] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 19, 2017 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Growth Hormone Treatment and Adverse Events.
Authors: Nishi Y, Tanaka T Abstract We compiled the major adverse events included in the Annual Research Reports of the Foundation for Growth Research published in and after 2000. We conducted a review of approximately 32,000 patients treated with growth hormone (GH) who subsequently developed leukemia and who were registered with the Foundation for Growth Research (from 1975 to December 31 1997). We performed a literature review and found that GH therapy was not associated with leukemia onset in patients with no risk factors for leukemia. We also reported the onset of diabetes mellitus (DM), scoliosis, and respira...
Source: Pediatric Endocrinology Reviews - May 19, 2017 Category: Endocrinology Tags: Pediatr Endocrinol Rev Source Type: research

The Lung in Rare Systemic Diseases
Respiration (Source: Respiration)
Source: Respiration - May 19, 2017 Category: Respiratory Medicine Source Type: research

New aspects in the diagnosis and treatment of primary spontaneous pneumothorax.
Authors: Dżeljilji A, Rokicki W, Rokicki M, Karuś K Abstract This paper provides a recapitulation of the position of the British Thoracic Society and the American College of Chest Physicians based on a review of the literature concerning the current methods of diagnosing and treating primary spontaneous pneumothorax (PSP). The previously developed guidelines were re-evaluated in 2015 by a task force of the European Respiratory Society (ERS). They are intended to be used by surgeons as well as emergency and pulmonary ward physicians, and they apply largely to emergency procedures. In recent years, the effectiveness o...
Source: Polish Journal of Cardio-Thoracic Surgery - May 19, 2017 Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research

Respiratory functional status after conventional and minimally invasive aortic valve replacement surgery - a propensity score analysis.
CONCLUSIONS: Respiratory function based on spirometry examinations was less impaired after minimally invasive RT-AVR surgery in comparison to conventional AVR surgery through median sternotomy. PMID: 28515741 [PubMed - in process] (Source: Polish Journal of Cardio-Thoracic Surgery)
Source: Polish Journal of Cardio-Thoracic Surgery - May 19, 2017 Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research

COPD Screening Program: What Is the Appropriate Target Group Population
Respiration (Source: Respiration)
Source: Respiration - May 19, 2017 Category: Respiratory Medicine Source Type: research

Combined measurements of fractional exhaled nitric oxide and nasal nitric oxide levels for assessing upper airway diseases in asthmatic patients.
CONCLUSIONS: Higher nasal NO levels reflect the presence of allergic rhinitis, irrespective of asthma concomitance. Higher FeNO50 levels reflect the presence of CRS and asthma. These NO measurements are useful for assessing comorbid UAD in asthmatics. PMID: 28513250 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 19, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research