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Mild Chronic Obstructive Pulmonary Disease: Why Spirometry Is Not Sufficient!
Authors: Elbehairy AF, Parraga G, Webb KA, Neder JA, O'Donnell DE, Canadian Respiratory Research Network (CRRN) Abstract INTRODUCTION: Chronic obstructive pulmonary disease (COPD) - an inflammatory disease of the airways, alveoli and lung microvasculature - is a leading cause of death worldwide. Smokers with milder airway obstruction constitute the majority of patients with this disease. Many studies have shown increased morbidity, activity-related dyspnea, exercise intolerance and mortality in such patients, compared with age-matched healthy populations. Clinical evaluation of symptomatic smokers with ostensibly m...
Source: Expert Review of Respiratory Medicine - May 28, 2017 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Inhaled corticosteroid prescribing in a pediatric emergency department: Sustained success and prescription filling rates.
CONCLUSIONS: The ICS prescribing rate remained the goal of 75% over a 2.5-year period after transition to a low-intervention phase. High ICS fill rates immediately after ED visit have been demonstrated. However, rapid decline in these rates over subsequent months suggests a need for future efforts to focus on long-term ICS adherence among children with ED visits for asthma. PMID: 28548868 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 28, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Implementation of asthma clinical practice guidelines in primary care: A cross-sectional study based on the Knowledge-to-Action Cycle.
CONCLUSIONS: Our results suggest that the implementation of asthma CPGs remains suboptimal in primary care. Interventions addressing the identified barriers and providing facilitators to asthma CPG implementation, such as continuing education, could be implemented and evaluated to sustain asthma CPG use in primary care settings. PMID: 28548896 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 28, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Comparison of a rapid albuterol pathway with a standard pathway for the treatment of children with a moderate to severe asthma exacerbation in the emergency department.
CONCLUSION: A rapid albuterol treatment pathway that utilizes a breath-enhanced nebulizer is an effective alternative to traditional pathways that utilize continuous nebulizations for children with moderate to severe asthma exacerbations in the ED. PMID: 28548898 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 28, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Utilization of a patient-centered asthma passport tool in a subspecialty clinic.
CONCLUSIONS: A patient-centered checklist significantly improved the completion rate of the AAP. For patient's who completed and returned the asthma passport, the ACT completion rate was also improved. Participants and providers reported high satisfaction with the checklist, suggesting that it can effectively promote asthma self-management and self-assessment without burdening clinicians or clinic workflow. PMID: 28548904 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 28, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Effectiveness of a Respiratory Day Hospital Program to Reduce Admissions for Exacerbation in Patients with Severe COPD: A Prospective, Multicenter Study.
Authors: Huertas D, Montón C, Marín A, Solanes I, López-Sánchez M, Pomares X, Muñoz-Esquerre M, Dorca J, Santos S Abstract The respiratory Day Hospital (DH) is a care facility currently operating at various healthcare institutions. It monitors patients with severe chronic obstructive pulmonary disease (COPD) presenting repeated exacerbations with at least two hospital admissions per year. The main aim of the study was to evaluate the effectiveness of the DH program for controlling admissions for COPD exacerbations in this cohort of patients, and to identify clinical factors associ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - May 28, 2017 Category: Respiratory Medicine Tags: COPD Source Type: research

Prognostic role of lncRNA TUG1 for cancer outcome: Evidence from 840 cancer patients.
Authors: Liu J, Lin J, Li Y, Zhang Y, Chen X Abstract LncRNA TUG1 has been demonstrated to be aberrantly expressed in several types of cancer and maybe serve as a prognostic marker for cancer patients. However, most individual studies have been limited by small sample sizes and controversial results. Therefore, this meta analysis was conducted to analyze available data to delineate the potential clinical application of lncRNA TUG1 on cancer prognosis, lymph node metastasis and tumor progression. Up to February 20, 2017, literature collections were conducted by comprehensive searching electronic databases, including...
Source: Oncotarget - May 28, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Influence of sulfur dioxide on the respiratory system of Miyakejima adult residents 6 years after returning to the island.
CONCLUSION: Adult residents of Miyakejima island showed no deterioration in pulmonary function at SO2 levels, but complained of respiratory/irritative symptoms in an SO2 concentration- dependent manner. PMID: 28539534 [PubMed - as supplied by publisher] (Source: Journal of Occupational Health)
Source: Journal of Occupational Health - May 27, 2017 Category: Occupational Health Tags: J Occup Health Source Type: research

Imagine all the people sharing all the world ….
Imagine all the people sharing all the world…. J Thorac Dis. 2017 Apr;9(Suppl 4):S223-S224 Authors: Gaudino M, Di Franco A, Rong LQ PMID: 28540064 [PubMed - in process] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Dynamic and quantitative evaluation of degenerative mitral valve disease: a dedicated framework based on cardiac magnetic resonance imaging.
Authors: Sturla F, Onorati F, Puppini G, Pappalardo OA, Selmi M, Votta E, Faggian G, Redaelli A Abstract BACKGROUND: Accurate quantification of mitral valve (MV) morphology and dynamic behavior over the cardiac cycle is crucial to understand the mechanisms of degenerative MV dysfunction and to guide the surgical intervention. Cardiac magnetic resonance (CMR) imaging has progressively been adopted to evaluate MV pathophysiology, although a dedicated framework is required to perform a quantitative assessment of the functional MV anatomy. METHODS: We investigated MV dynamic behavior in subjects with normal MV anat...
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Cine-CMR partial voxel segmentation demonstrates increased aortic stiffness among patients with Marfan syndrome.
Authors: Singh P, Almarzooq Z, Codell NCF, Wang Y, Roman MJ, Devereux RB, Weinsaft JW Abstract BACKGROUND: Standard cine-cardiac magnetic resonance (CMR) imaging is commonly used to evaluate cardiac structure, geometry and function. Prior studies have shown that automated segmentation via partial voxel interpolation (PVI) accurately quantifies phantom-based cardiac chamber volumes and necropsy left ventricular myocardial mass. Despite this, the applicability and usefulness of PVI in the determination of physiologic parameters of the aorta such as aortic stiffness has yet to be investigated. METHODS: Routine CMR...
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Utility of cardiac magnetic resonance for evaluation of mitral regurgitation prior to mitral valve surgery.
Authors: Mehta NK, Kim J, Siden JY, Rodriguez-Diego S, Alakbarli J, Di Franco A, Weinsaft JW Abstract Mitral regurgitation (MR) is a common cause of morbidity worldwide and an accepted indication for interventional therapies which aim to reduce or resolve adverse clinical outcomes associated with MR. Cardiac magnetic resonance (CMR) provides highly accurate means of assessing MR, including a variety of approaches that can measure MR based on quantitative flow. Additionally, CMR is widely accepted as a reference standard for cardiac chamber quantification, enabling reliable detection of subtle changes in cardiac cha...
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Serendipity and innovation: history and evolution of transthoracic echocardiography.
Authors: Di Franco A, Ohmes LB, Gaudino M, Rong LQ, Girardi LN, Sarullo FM, Salerno Y, Sarullo S, Weinsaft JW, Kim J Abstract The history of echocardiography is sprinkled with many interesting episodes and anecdotes showing that devoting your life to the pursuit of one goal is praiseworthy, and that at the same time, a little luck goes a long way. Transthoracic echocardiography (TTE) has led to dramatic improvements in cardiovascular medicine, and is now the most widely used diagnostic cardiac test after electrocardiography (ECG). The present review pays tribute to the pioneering efforts of those who believed in th...
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Integrate imaging approach for minimally invasive and robotic procedures.
Authors: Ivanov NA, Green DB, Guy TS Abstract Over the past two decades, robotic and minimally invasive cardiac surgery has been continuously refined and is currently an alternative to traditional open-heart surgery for some patients. The parallel evolution of imaging modalities has made robotic surgery safer and more efficient. Here, we review the pre- and post-operative use of computed tomography (CT) in minimally invasive and robotic cardiac procedures. PMID: 28540069 [PubMed - in process] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

An update on intraoperative three-dimensional transesophageal echocardiography.
Authors: Rong LQ Abstract Transesophageal echocardiography (TEE) was first used routinely in the operating rooms in the 1980s to facilitate surgical decision-making. Since then, TEE has evolved from the standard two-dimensional (2D) exam to include focused real-time three-dimensional (RT-3D) imaging both inside and outside the operating rooms. Improved spatial and temporal resolution due to technological advances has expedited surgical interventions in diseased valves. 3D imaging has also emerged as a crucial adjunct in percutaneous interventions for structural heart disease. With continued advancement in software,...
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

CT angio for the evaluation of graft patency.
Authors: Di Lazzaro D, Crusco F Abstract Invasive coronary angiography (ICA) is the traditional method for the follow-up of graft patency in coronary artery bypass graft (CABG) patients. Nevertheless, the advent of multidetector computed tomography (MDCT) opened new perspectives for using a noninvasive, equally reliable method to study CABG patients. This review article will analyze the current feasibility of modern multi-slice MDCT, as well as its future perspectives. PMID: 28540071 [PubMed - in process] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Standard imaging techniques in transcatheter aortic valve replacement.
Authors: Salemi A, Worku BM Abstract Transcatheter aortic valve replacement (TAVR) has become a widely accepted therapeutic option for patients with severe, symptomatic aortic stenosis at intermediate, high, or extreme risk for conventional surgery as determined through a heart team approach. Two valve prostheses are currently available and the Food and Drug Administration (FDA) approved in the United States for TAVR: the self-expandable Medtronic CoreValve (Medtronic, Inc., Minneapolis, MN, USA) and the balloon-expandable Edwards Sapien Valve (Edwards Lifesciences, Irvine CA, USA). The preoperative evaluation for ...
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Viscoelastic testing inside and beyond the operating room.
Authors: Shen L, Tabaie S, Ivascu N Abstract Hemorrhage is a major contributor to morbidity and mortality during the perioperative period. Current methods of diagnosing coagulopathy have various limitations including long laboratory runtimes, lack of information on specific abnormalities of the coagulation cascade, lack of in vivo applicability, and lack of ability to guide the transfusion of blood products. Viscoelastic testing offers a promising solution to many of these problems. The two most-studied systems, thromboelastography (TEG) and rotational thromboelastometry (ROTEM), offer similar graphical and numeric...
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Imaging for surveillance and operative management for endovascular aortic aneurysm repairs.
Authors: Lau C, Feldman DN, Girardi LN, Kim LK Abstract Endovascular aortic aneurysm repairs rely heavily on radiologic imaging modalities for preoperative surveillance, intraoperative management, and postoperative follow-up. Ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI) and angiography all have utility at different stages of management. Often one imaging modality compliments another by providing supplementary information. Data from the imaging exams must be synthesized into one coherent plan for managing patients with aortic aneurysms. PMID: 28540074 [PubMed - in process] (Source:...
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Fractional flow reserve to guide surgical coronary revascularization.
Authors: Shah T, Geleris JD, Zhong M, Swaminathan RV, Kim LK, Feldman DN Abstract Coronary angiography has traditionally been used as the final diagnostic tool in the evaluation of coronary artery disease (CAD). However, conventional angiography identifies anatomically obstructive coronary disease, but it is limited in its ability to identify hemodynamically significant lesions. The emergence of fractional flow reserve (FFR) technology, in conjunction with angiography, offers a functional, as well as anatomic, assessment of epicardial coronary obstructions. Several pivotal studies have demonstrated that FFR-guided ...
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Techniques for intraoperative graft assessment in coronary artery bypass surgery.
Authors: Ohmes LB, Di Franco A, Di Giammarco G, Rosati CM, Lau C, Girardi LN, Massetti M, Gaudino M Abstract Early graft patency is a major determinant of morbidity and mortality following coronary artery bypass surgery. Long-term graft failure is caused by intimal hyperplasia and atherosclerosis, while early failure, especially in the first year, has been attributed, in part, to surgical error. The need for intraoperative graft evaluation is paramount to determine need for revision and ensure future functioning grafts. Transit time flowmetry (TTFM) is the most commonly used intraoperative modality, however, only a...
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Role of molecular imaging with positron emission tomographic in aortic aneurysms.
Authors: Singh P, Almarzooq Z, Salata B, Devereux RB Abstract Aortic aneurysms (AA) are often asymptomatic before the occurrence of acute, potentially fatal complications including dissection and/or rupture. Beyond aortic size, the ability to assess aortic wall characteristics and processes contributing to aneurysm development may allow improved selection of patients who may benefit from prophylactic surgical intervention. Current risk stratification for aneurysms relies upon routine noninvasive imaging of aortic size without assessing the underlying pathophysiologic processes, including features such as inflammati...
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Use of multidetector-row computed tomography scan to detect pannus formation in prosthetic mechanical aortic valves.
Authors: Aladmawi MA, Pragliola C, Vriz O, Galzerano D Abstract Obstruction of a mechanical aortic valve by pannus formation at the subvalvular level is a major long-term complication of aortic valve replacement (AVR). In fact, pannus is sometime difficult to differentiate from patient-prosthesis mismatch or valve thrombosis. In most cases cine-angiography and echocardiography, either transthoracic or transesophageal, cannot correctly visualize the complication when the leaflets show a normal mobility. Recent technological refinements made this difficult diagnosis possible by ECG-gated computed tomography (CT) scan...
Source: Journal of Thoracic Disease - May 27, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Linezolid-induced lactic acidosis: the thin line between bacterial and mitochondrial ribosomes.
Authors: Santini A, Ronchi D, Garbellini M, Piga D, Protti A Abstract Introduction - Linezolid inhibits bacterial growth by targeting bacterial ribosomes and by interfering with bacterial protein synthesis. Lactic acidosis is a rare, but potentially lethal, side effect of linezolid. Areas covered - The pathogenesis of linezolid-induced lactic acidosis is reviewed with special emphasis on aspects relevant to the recognition, prevention and treatment of the syndrome. Expert opinion - Linezolid-induced lactic acidosis reflects the untoward interaction between the drug and mitochondrial ribosomes. The inhibition of mit...
Source: Expert Opinion on Drug Safety - May 27, 2017 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Supraventricular tachycardia after withdrawal of prolonged dexmedetomidine infusion in a paediatric patient without heart disease
ConclusionThis is the first report of PSVT as an adverse reaction to DEX in a paediatric patient without heart disease. Dexmedetomidine has been reported safe in paediatric patients. In this report, we communicate a case of paroxysmal supraventricular tachycardia (PSVT) after DEX withdrawal in a four years‐old girl with no former history of heart disease. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - May 27, 2017 Category: Drugs & Pharmacology Authors: J. Carlos Flores ‐González, Ana Estalella‐Mendoza, Alfonso M. Lechuga‐Sancho, Arturo Hernández‐González, Fernando Rubio‐Quiñones, Patricia Rodríguez‐Campoy, Mónica Saldaña‐Valderas Tags: CASE REPORT Source Type: research

Mycoplasma pneumoniae from the Respiratory Tract and Beyond.
Abstract Mycoplasma pneumoniae is an important cause of respiratory tract infections in children as well as adults that can range in severity from mild to life-threatening. Over the past several years there has been much new information published concerning infections caused by this organism. New molecular-based tests for M. pneumoniae detection are now commercially available in the United States, and advances in molecular typing systems have enhanced understanding of the epidemiology of infections. More strains have had their entire genome sequences published, providing additional insights into pathogenic mechani...
Source: Clinical Microbiology Reviews - May 27, 2017 Category: Microbiology Authors: Waites KB, Xiao L, Liu Y, Balish MF, Atkinson TP Tags: Clin Microbiol Rev Source Type: research

Surfactant for Respiratory Distress Syndrome: New Ideas on a Familiar Drug with Innovative Applications.
BW Abstract In the last 4 decades, advances in neonatology have led to a significant increase in the survival of preterm infants. One of the biggest advances was the introduction of surfactant replacement therapy for the treatment of respiratory distress syndrome. This is the main cause of respiratory insufficiency in preterm infants and is one of the major causes of perinatal morbidity and mortality. Surfactant replacement therapy is already a well-investigated and established therapy in neonatology. However, surfactant replacement therapy has progressed and been refined over recent decades, especially with the ...
Source: Neonatology - May 27, 2017 Category: Perinatology & Neonatology Authors: Niemarkt HJ, Hütten MC, Kramer BW Tags: Neonatology Source Type: research

Update on Postnatal Steroids.
Abstract Antenatal steroid treatment to enhance fetal lung maturity and surfactant treatment to prevent or treat respiratory distress syndrome have been major advances in perinatal medicine in the past 40 years contributing to improved outcomes for preterm infants. Use of postnatal steroids to prevent or treat chronic lung disease in preterm infants has been less successful and associated with adverse neurodevelopmental outcomes. Although early (in the first week of life) postnatal steroid treatment facilitates earlier extubation and reduces the risk of chronic lung disease, it is associated with adverse effects, ...
Source: Neonatology - May 27, 2017 Category: Perinatology & Neonatology Authors: Halliday HL Tags: Neonatology Source Type: research

Agreement between heart failure patients and providers in assessing New York Heart Association functional class
Conclusion Patients and providers exhibited poor agreement in NYHA assignment. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - May 27, 2017 Category: Respiratory Medicine Source Type: research

Host genetics in susceptibility to and severity of mycobacterial diseases
The genetic analysis of susceptibility to infections has proven to be extremely useful for identification of key cells, molecules, pathways, and genes involved in the battle between two genomes – the essence of the infectious process. This is particularly true for tuberculosis and other mycobacterial infections which traditionally attracted much attention from both immunologists and geneticists. In this short review, we observe results of genetic studies performed in human populations an d in animal models and compare relative input of forward and reverse genetic approaches in our knowledge about genetic control of a...
Source: Tuberculosis - May 27, 2017 Category: Respiratory Medicine Authors: A.S. Apt, N.N. Logunova, T.K. Kondratieva Tags: Review Source Type: research

Respiratory and swallowing outcomes based on aneurysm location in 360 patients with subarachnoid hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) may result in abnormal respiratory and swallowing function. We analyzed factors that may influence long-term respiratory and swallowing function in aSAH patients, and compared patients with anterior and posterior aneurysm locations. (Source: World Neurosurgery)
Source: World Neurosurgery - May 27, 2017 Category: Neurosurgery Authors: Isaac Josh Abecassis, Ryan P. Morton, Lynn McGrath, Josiah Hanson, Anna H. Xue, Cory M. Kelly, Michael R. Levitt, Laligam N. Sekhar, Louis J. Kim Tags: Original article Source Type: research

Total IgM and Anti-Phosphatidylcholine IgM Antibody Secretion Continue After Clearance of Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection
AbstractThe cellular immune response toMycobacterium tuberculosis infection has been well characterized, while the humoral antibody response remains underexplored. We aimed to examine the total and anti-phospholipid IgM levels in the pleural lavage from mice withMycobacterium bovis BCG extrapulmonary infection. We found that the levels of total and anti-phosphatidylcholine IgM antibodies remained significantly higher in infected mice as compared to non-infected mice up to day 90 after BCG infection, while the anti-cardiolipin IgM antibody levels decreased with bacteria clearance. Our findings suggest that IgM antibodies ar...
Source: Lung - May 27, 2017 Category: Respiratory Medicine Source Type: research

Extraskeletal Osteosarcoma Arising from the Pleura
(Source: Lung)
Source: Lung - May 27, 2017 Category: Respiratory Medicine Source Type: research

Clinical trials in acute respiratory distress syndrome: challenges and opportunities
Publication date: June 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 6 Author(s): Michael A Matthay, Daniel F McAuley, Lorraine B Ware This year is the 50th anniversary of the first description of acute respiratory distress syndrome (ARDS). Since then, much has been learned about the pathogenesis of lung injury in ARDS, with an emphasis on the mechanisms of injury to the lung endothelium and the alveolar epithelium. In terms of treatment, major progress has been made in reducing mortality from ARDS with lung-protective ventilation, using a tidal volume of 6 mL per kg of predicted bodyweight and a plateau ai...
Source: The Lancet Respiratory Medicine - May 27, 2017 Category: Respiratory Medicine Source Type: research

Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome
Publication date: June 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 6 Author(s): Nuala J Meyer, Carolyn S Calfee In the 50 years since acute respiratory distress syndrome (ARDS) was first described, substantial progress has been made in identifying the risk factors for and the pathogenic contributors to the syndrome and in characterising the protein expression patterns in plasma and bronchoalveolar lavage fluid from patients with ARDS. Despite this effort, however, pharmacological options for ARDS remain scarce. Frequently cited reasons for this absence of specific drug therapies include the heterogeneity ...
Source: The Lancet Respiratory Medicine - May 27, 2017 Category: Respiratory Medicine Source Type: research

David Ashbaugh reminisces
Publication date: June 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 6 Author(s): David Ashbaugh (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - May 27, 2017 Category: Respiratory Medicine Source Type: research

Hard to say goodbye
Publication date: June 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 6 Author(s): Aaron van Dorn (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - May 27, 2017 Category: Respiratory Medicine Source Type: research

Mesenchymal stem cell treatment for IPF —time for phase 2 trials?
Publication date: June 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 6 Author(s): Katerina M Antoniou, Konstantinos Karagiannis, Eliza Tsitoura, Nikos Tzanakis (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - May 27, 2017 Category: Respiratory Medicine Source Type: research

Thomas L Petty
Publication date: June 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 6 Author(s): Rebecca Akkermans (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - May 27, 2017 Category: Respiratory Medicine Source Type: research

Reappraisal of the clinical effect of mepolizumab – Authors' reply
Publication date: June 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 6 Author(s): Geoffrey L Chupp, Eric S Bradford, Frank C Albers, Daniel J Bratton, Jie Wang-Jairaj, Linda M Nelsen, Jennifer L Trevor, Antoine Magnan (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - May 27, 2017 Category: Respiratory Medicine Source Type: research

Reappraisal of the clinical effect of mepolizumab
Publication date: June 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 6 Author(s): Brian J Lipworth, Sunny Jabbal (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - May 27, 2017 Category: Respiratory Medicine Source Type: research

Clinical trial research in focus: time to reflect on the design of exacerbation trials in COPD
Publication date: June 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 6 Author(s): Jørgen Vestbo, Ashley Woodcock (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - May 27, 2017 Category: Respiratory Medicine Source Type: research

Whose advance directives are they, after all?
Publication date: June 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 6 Author(s): Samuel M Brown (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - May 27, 2017 Category: Respiratory Medicine Source Type: research

Effect of portable non-invasive ventilation & amp; environmental conditions on everyday activities
Publication date: Available online 26 May 2017 Source:Respiratory Physiology & Neurobiology Author(s): Anna Bajema, Anne L. Swinbourne, Marion Gray, Anthony S. Leicht The current study examined the effect of non-invasive ventilation (NIV) within environments of differing temperature and humidity on several physiological and perceptual responses while performing six activities of daily living (i.e. putting on shirt/shoes/trousers, vacuuming, hanging towels, and walking on a treadmill). Sixteen healthy participants completed the activities of varying difficulty within four experimental conditions: with and without N...
Source: Respiratory Physiology and Neurobiology - May 27, 2017 Category: Respiratory Medicine Source Type: research

Interstitial lung fluid balance in healthy lowlanders exposed to high-altitude
Publication date: Available online 26 May 2017 Source:Respiratory Physiology & Neurobiology Author(s): Bryan J. Taylor, Glenn M. Stewart, Jan W. Marck, Douglas T. Summerfield, Amine N. Issa, Bruce D. Johnson We aimed to assess lung fluid balance before and after gradual ascent to 5,150m. Lung diffusion capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO) and ultrasound lung comets (ULCs) were assessed in 12 healthy lowlanders at sea-level, and on Day 1, Day 5 and Day 9 after arrival at Mount Everest Base Camp (EBC). EBC was reached following an 8-day hike at progressively increasing ...
Source: Respiratory Physiology and Neurobiology - May 27, 2017 Category: Respiratory Medicine Source Type: research

An undiagnosed pleural effusion with surprising consequences
We present the case of a 43-year-old Italian woman with a left undiagnosed pleural effusion, which in subsequent months presented a clinically unexpected evolution with the appearance at first of a right wrist tenosynovitis and subsequently a bilateral lung involvement caused by M. Tuberculosis. With this case report, we would like to underline the importance of making a correct diagnosis of any pleural effusion as soon as possible by at least a thoracocentesis. If untreated, tuberculosis may easily disseminate to other organs. Some considerations and suggestions for antibiotic treatment of pleural effusion will also be gi...
Source: Respiratory Medicine Case Reports - May 27, 2017 Category: Respiratory Medicine Source Type: research

Primary ciliary dyskinesia presenting with spontaneous pneumothorax: Case report and review of the literature
Conclusions Pneumothorax might be one of the complications of the PCD. Combination therapy including ICS+ LA beta2 agonist and carbocistein could be a potential therapy to reduce the frequency of acute exacerbations and delay progression of PCD. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - May 27, 2017 Category: Respiratory Medicine Source Type: research

Non-traumatic Pulmonary Emergencies in the Deployed Setting
AbstractPurpose of ReviewPulmonary disorders accounted for up to 8% of the over 70,000 medical evacuations conducted from Iraq and Afghanistan in the past 15  years. This review of non-traumatic pulmonary emergencies provides an overview of deployed military medical treatment capabilities and highlights pulmonary emergencies requiring aeromedical evacuation from theater.Recent FindingsRecent studies have improved the epidemiologic evaluation of non-traumatic pulmonary disease, highlighted specific parenchymal diseases, and revealed infection pathologies unique to the deployed setting. Literature regarding possible che...
Source: Current Respiratory Care Reports - May 27, 2017 Category: Respiratory Medicine Source Type: research

Consecutive yearly outbreaks of respiratory syncytial virus in a haemato-oncology ward and efficacy of infection control measures
Conclusion There was significant learning from both outbreaks and actions implemented with the aim of reducing the likelihood and impact of future outbreaks. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - May 27, 2017 Category: Infectious Diseases Source Type: research

Optimization of Mitochondrial Isolation Techniques for Intraspinal Transplantation Procedures
Conclusions These techniques lay the foundation for testing the potential therapeutic effects of mitochondrial transplantation following spinal cord injury and other animal models of neurotrauma. (Source: Journal of Neuroscience Methods)
Source: Journal of Neuroscience Methods - May 27, 2017 Category: Neuroscience Source Type: research