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Therapeutic Hypothermia for Acute Respiratory Distress Syndrome
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 17, 2017 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Does Driving Pressure Matter in Pediatric Acute Respiratory Distress Syndrome? Strain to Find the Answer
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 17, 2017 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

Effects on Pulmonary Vascular Mechanics of Two Different Lung-Protective Ventilation Strategies in an Experimental Model of Acute Respiratory Distress Syndrome
Objectives: Objectives:To compare the effects of two lung-protective ventilation strategies on pulmonary vascular mechanics in early acute respiratory distress syndrome. Design: Design:Experimental study. Setting: Setting:University animal research laboratory. Subjects: Subjects:Twelve pigs (30.8 ± 2.5 kg). Interventions: Interventions:Acute respiratory distress syndrome was induced by repeated lung lavages and injurious mechanical ventilation. Thereafter, animals were randomized to 4 hours ventilation according to the Acute Respiratory Distress Syndrome Network protocol or to an open lung a...
Source: Critical Care Medicine - October 17, 2017 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Just Because Things Are Not Different, Does Not Mean They Are the Same: Biomarker Patterns in Acute Respiratory Distress Syndrome*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 17, 2017 Category: Emergency Medicine Tags: Editorials Source Type: research

Pediatric Acute Respiratory Distress Syndrome in Asia: None of Us Is as Smart as All of Us*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 17, 2017 Category: Emergency Medicine Tags: Editorials Source Type: research

Sedation and Mobilization During Venovenous Extracorporeal Membrane Oxygenation for Acute Respiratory Failure: An International Survey
Conclusions: Conclusions:The majority of respondents reported targeting moderate to deep sedation following cannulation, with the use of sedative and opioid infusions. There is considerable variability surrounding early physical therapy and mobilization goals for patients with acute respiratory failure supported by venovenous extracorporeal membrane oxygenation. (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 17, 2017 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Hypoxemic Patients With Bilateral Infiltrates Treated With High-Flow Nasal Cannula Present a Similar Pattern of Biomarkers of Inflammation and Injury to Acute Respiratory Distress Syndrome Patients*
Conclusions: Conclusions:Acute hypoxemic patients with bilateral infiltrates treated with high-flow nasal cannula presented a similar pattern of biomarkers of inflammation and injury to acute respiratory distress syndrome patients undergoing direct mechanical ventilation. The results suggest that these high-flow nasal cannula patients should be considered as acute respiratory distress syndrome patients. (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 17, 2017 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Risk Stratification in Pediatric Acute Respiratory Distress Syndrome: A Multicenter Observational Study*
Objectives: Objectives:The Pediatric Acute Lung Injury Consensus Conference developed a pediatric specific definition for acute respiratory distress syndrome (PARDS). In this definition, severity of lung disease is stratified into mild, moderate, and severe groups. We aim to describe the epidemiology of patients with PARDS across Asia and evaluate whether the Pediatric Acute Lung Injury Consensus Conference risk stratification accurately predicts outcome in PARDS. Design: Design:A multicenter, retrospective, descriptive cohort study. Setting: Setting:Ten multidisciplinary PICUs in Asia. Patients: Patients:All mechanical...
Source: Critical Care Medicine - October 17, 2017 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Opioid use disorder and misuse: A review of the epidemiology and medical implications for pediatric anesthesiologists.
Abstract This educational review presents an overview of opioid use disorder, misuse and overdose among adolescents, and the clinical implications for anesthesiologists. It provides definitions, discusses the epidemiology worldwide, (focusing on North America), and emphasizes the clinical implications of patients with chronic opioid exposure, including perioperative pain management, as well as opioid overdose and prolonged use of opioids after acute exposure. In the USA, opioid use disorder and negative outcomes related to opioids rose dramatically from 1999-2010; concomitantly heroin use and fatal overdoses have ...
Source: Paediatric Anaesthesia - October 17, 2017 Category: Anesthesiology Authors: Knipper E, Banta-Green CJ, Jimenez N Tags: Paediatr Anaesth Source Type: research

Physiopathology and genetics in aspirin-exacerbated respiratory disease.
CONCLUSIONS: Genetic association research in AERD has evaluated studies of SNPs in metabolic pathways related to arachidonic acid. Recently, whole genome analysis strategies have allowed the detection of new genetic variants that were previously not considered. Furthermore, these studies have identified SNPs that are associated with inflammatory processes, which could serve as diagnostic markers or predictors of the therapeutic response. PMID: 29035123 [PubMed - as supplied by publisher] (Source: Experimental Lung Research)
Source: Experimental Lung Research - October 17, 2017 Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research

F508del CFTR gene mutation in patients with allergic bronchopulmonary aspergillosis.
CONCLUSIONS: In our ABPA patient cohort, the presence of the delta F508 mutation was higher than that seen in general population. Genetic counseling for CFTR genotyping might be appropriate for these patients. PMID: 29035608 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - October 17, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Editorial Board
(Source: Tuberculosis)
Source: Tuberculosis - October 17, 2017 Category: Respiratory Medicine Source Type: research

Organ Dysfunction and Failure Following Brain Death Do Not Preclude Successful Donation
ConclusionCurrent measures of organ failure and dysfunction do not predict the success of organ donation. Successful donor management in the face of severe organ dysfunction and failure can result in lives saved. (Source: World Journal of Surgery)
Source: World Journal of Surgery - October 17, 2017 Category: Surgery Source Type: research

Plasma Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome: A Multicenter Survival and Longitudinal Prospective Observation Study: Erratum
No abstract available (Source: Shock)
Source: Shock - October 17, 2017 Category: Emergency Medicine Tags: Erratum Source Type: research

Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice
Conclusions: These results suggest that strain-specific changes in chromatin and transcription in response to chemical exposure lead to a “compensation” for underlying genetic-driven interindividual differences in the baseline chromatin and transcriptional state. This work represents an example of how chemical and environmental exposures can be evaluated to better understand gene-by-environment interactions, and it demonstrates the important role of chromatin response in transcriptomic changes and, potentially, in deleterious effects of exposure. https://doi.org/10.1289/EHP1937 Received: 21 March 2017 Revis...
Source: EHP Research - October 17, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

High-frequency epidural stimulation across the respiratory cycle evokes phrenic short-term potentiation after incomplete cervical spinal cord injury
This study examined HF-ES and phrenic motor output following subacute and chronic incomplete cervical spinal cord injury. Short-term potentiation of phrenic bursting following HF-ES illustrates the potential for spinal stimulation to induce respiratory neuroplasticity. Increased tonic phrenic output indicates that alternatives to the continuous stimulation paradigm used in this study will be required for respiratory muscle activation after spinal cord injury. (Source: Journal of Neurophysiology)
Source: Journal of Neurophysiology - October 17, 2017 Category: Neurology Authors: Gonzalez-Rothi, E. J., Streeter, K. A., Hanna, M. H., Stamas, A. C., Reier, P. J., Baekey, D. M., Fuller, D. D. Tags: Research Articles Source Type: research

Isoflurane, ketamine-xylazine, and urethane markedly alter breathing even at subtherapeutic doses
Anesthetics are widely used for animal research on respiratory control in vivo, but their effect on breathing and CO2 chemoreception has not been well characterized in mice, a species now often used for these studies. We previously demonstrated that 1% isoflurane markedly reduces the hypercapnic ventilatory response (HCVR) in adult mice in vivo and masks serotonin [5-hydroxytryptamine (5-HT)] neuron chemosensitivity in vitro. Here we investigated effects of 0.5% isoflurane on breathing in adult mice and also found a large reduction in the HCVR even at this subanesthetic concentration. We then tested the effects on breathin...
Source: Journal of Neurophysiology - October 17, 2017 Category: Neurology Authors: Massey, C. A., Richerson, G. B. Tags: Research Articles Source Type: research

Acute mitochondrial myopathy with respiratory insufficiency and motor axonal polyneuropathy
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - October 17, 2017 Category: Neuroscience Authors: Ying Zhou Jianhua Yi Li Liu Xiaoping Wang Liang Dong Ailian Du Source Type: research

Dyspnea, eosinopenia, consolidation, acidemia and atrial fibrillation score and BAP-65 score, tools for prediction of mortality in acute exacerbations of chronic obstructive pulmonary disease: A comparative pilot study
Conclusion: Both DECAF and BAP-65 scores were found to be good predictors of mortality and need for ventilation in this pilot study. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - October 17, 2017 Category: Intensive Care Authors: Viral Sangwan Dhruva Chaudhry Roopa Malik Source Type: research

Assessment of doripenem, meropenem, and imipenem against respiratory isolates of Pseudomonas aeroginosa in a tertiary care hospital of north India
Conclusion: Our study revealed that doripenem exerted better in vitro activity against the tested bacteria compared to imipenem and meropenem, but the difference was not statistically significant. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - October 17, 2017 Category: Intensive Care Authors: Arti Negi Mridu Anand Avinash Singh Awadhesh Kumar Chinmoy Sahu Kashi Nath Prasad Source Type: research

Hypercapnic respiratory failure in case of chiari 1.5 malformation: Case Report and review of the literature
We report a 35-year-old male who presented with acute hypercapnic respiratory failure (Type 2), without any preexisting neurological or respiratory abnormality. Analysis of blood gases in emergency revealed a pH of 7.12, pCO2of 132 mmHg, and arterial oxygen tension of 118 mm Hg. He was intubated and ventilated. Magnetic resonance imaging brain revealed herniation of the cerebellar tonsils along with brain stem and fourth ventricle. The patient underwent surgery and gradually weaned off. He was mobilized and discharged on day 6. Acute respiratory failure has not been reported with Chiari 1.5 malformation. The lesson to be l...
Source: Indian Journal of Critical Care Medicine - October 17, 2017 Category: Intensive Care Authors: Viralkumar M Vasani Subhas Kanti Konar S Satish Source Type: research

IJERPH, Vol. 14, Pages 1241: Dampness and Moisture Problems in Norwegian Homes
oslash;s Johan Øvrevik The occurrence of dampness and mold in the indoor environment is associated with respiratory-related disease outcomes. Thus, it is pertinent to know the magnitude of such indoor environment problems to be able to estimate the potential health impact in the population. In the present study, the moisture damage in 10,112 Norwegian dwellings was recorded based on building inspection reports. The levels of moisture damage were graded based on a condition class (CC), where CC0 is immaculate and CC1 acceptable (actions not required), while CC2 and CC3 indicate increased levels of damage that r...
Source: International Journal of Environmental Research and Public Health - October 17, 2017 Category: Environmental Health Authors: Rune Becher Anja Hortemo H øie Jan Vilhelm Bakke Sverre Bj ørn Holøs Johan Øvrevik Tags: Article Source Type: research

The Differences in Spirometry Predictive Equations in Classifying Presence and Degree of Lung Function Impairment: Which Suit Fits the Best?
AbstractPurposeThe aim of this study was to compare the differences between three most commonly used predictive equations (PE): ECCS (European Community of Coal and Steel), the third National Health and Nutrition Examination Survey (NHANES III), and GLI (Global Lung Initiative) in healthy individuals and when grading severity of lung function impairment in patients with obstructive lung diseases.MethodsThe study included 200 healthy volunteers and 200 patients with obstructive lung diseases at the Institute for Pulmonary Diseases of Vojvodina. In all subjects, we calculated the absolute and relative (percent) predicted val...
Source: Lung - October 17, 2017 Category: Respiratory Medicine Source Type: research

What every intensivist should know about acute respiratory distress syndrome and diffuse alveolar damage
RESUMO A s índrome do desconforto respiratório agudo é um desafio para o intensivista. A característica principal desta doença aguda é o dano alveolar difuso, presente em cerca de metade dos pacientes com a síndrome. É claro que o suporte respiratório à síndrome do desconforto respiratório agudo te m melhorado gradualmente nas últimas décadas. É também evidente que todos estes procedimentos são benéficos, já que reduzem a lesão pulmonar e mantêm o paciente vivo. Isto deve ser int...
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Extracorporeal membrane oxygenation in acute respiratory distress syndrome due to influenza A (H1N1)pdm09 pneumonia. A single-center experience during the 2013-2014 season
Conclusion: The survivors were relatively young and discharged with good functional status (i.e., enhancing quality-adjusted life-years-saved). Our experience shows that even a relatively new extracorporeal membrane oxygenation program can play an important role in that capacity and provide excellent outcomes for the sickest patients. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

The patient with a complex chronic respiratory disease: a specialist of his own life?
Authors: Houben-Wilke S, Augustin IM, Wouters BB, Stevens R, Janssen DJA, Spruit MA, Vanfleteren LE, Franssen FM, Wouters EF Abstract INTRODUCTION: The independent and central role of the patient with a complex chronic respiratory disease in targeted, personalized disease management strategies is becoming increasingly important. Patients are the ones living with the disease and are finally responsible for their lives underlining their role as essential members of the interdisciplinary treatment team. Areas covered: The present paper narratively reviews existing research and discusses the special, as well as special...
Source: Expert Review of Respiratory Medicine - October 16, 2017 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Interprofessional Pulmocheck care pathway: An innovative approach to managing pediatric asthma care in the Netherlands.
CONCLUSIONS: The specialty pediatric asthma care pathway revealed a high number of children with newly diagnosed asthma, but was also helpful to exclude this diagnosis. However, the referral rate of GPs to this pathway was low, but in the children, that were referred several changes in the clinical management were advised and the frequency of monitoring of the children with diagnosed asthma was not in accordance with the asthma guidelines. PMID: 29028376 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - October 16, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

A computable phenotype for asthma case identification in adult and pediatric patients: External validation in The Chicago Area Patient-Outcomes Research Network (CAPriCORN).
CONCLUSIONS: The excellent positive and negative predictive values in this multi-center external validation study establish a useful tool to identify asthma cases in in the electronic health record for research and care. This computable phenotype could be used in large-scale comparative-effectiveness trials. PMID: 29027824 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - October 16, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Issue Information
(Source: Respirology Case Reports)
Source: Respirology Case Reports - October 16, 2017 Category: Respiratory Medicine Tags: Issue Information Source Type: research

Perioperative pain management in cardiac surgery: a systematic review.
CONCLUSIONS: Over the past 17 years, opioids are still the most extensively used therapy, whereas we found only few trials investigating other drugs (e.g. paracetamol). Regional anesthesia techniques, especially thoracic epidural analgesia and intrathecal morphine administration, can effectively treat pain, but have not yet showed any significant impact on major clinical outcomes, with several concern related to their potential complications. To date multimodal analgesia with implementation of regional analgesia seems to be the best choice. In the future, better-designed studies should consider other drugs stratifying grou...
Source: Minerva Anestesiologica - October 16, 2017 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Use of a Remote Inhaler Monitoring Device to Measure Change in Inhaler Use with Chronic Obstructive Pulmonary Disease Exacerbations
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - October 16, 2017 Category: Respiratory Medicine Authors: Kaharu Sumino Emily R. Locke Sheryl Magzamen Ina Gylys-Colwell Olivier Humblet Huong Q. Nguyen Rachel M. Thomas Vincent S. Fan Source Type: research

Hybrid Lipid/Polymer Nanoparticles for Pulmonary Delivery of siRNA: Development and Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - October 16, 2017 Category: Respiratory Medicine Authors: Ivana d'Angelo Gabriella Costabile Estelle Durantie Paola Brocca Valeria Rondelli Annapina Russo Giulia Russo Agnese Miro Fabiana Quaglia Alke Petri-Fink Barbara Rothen-Rutishauser Francesca Ungaro Source Type: research

Homogeneity of Aerosol Deposition and Mucociliary Clearance are Improved Following Ivacaftor Treatment in Cystic Fibrosis
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - October 16, 2017 Category: Respiratory Medicine Authors: William D. Bennett Kirby L. Zeman Beth L. Laube Jihong Wu Gail Sharpless Peter J. Mogayzel Scott H. Donaldson Source Type: research

May Dietary Supplementation Augment Respiratory Burst in Wound-Site Inflammatory Cells?
Antioxidants& Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - October 16, 2017 Category: Research Authors: Amitava Das Ryan Dickerson Piya Das Ghatak Gayle M. Gordillo Scott Chaffee Abhijoy Saha Savita Khanna Sashwati Roy Source Type: research

Positive end-expiratory pressure adjusted for intra-abdominal pressure – A pilot study
Intra-abdominal hypertension (IAH) is associated with impaired respiratory function. Animal data suggest that positive end-expiratory pressure (PEEP) levels adjusted to intra-abdominal pressure (IAP) levels may counteract IAH-induced respiratory dysfunction.In this pilot study, our aims were to assess whether PEEP adjusted for IAP can be applied safely in patients with IAH. (Source: Journal of Critical Care)
Source: Journal of Critical Care - October 16, 2017 Category: Intensive Care Authors: Adrian Regli, Bart Leon De Keulenaer, Annamaria Palermo, Peter Vernon van Heerden Source Type: research

Preoperative Progressive Pneumoperitoneum in Obese Patients With Loss of Domain Hernias
Repair of hernias with loss of domain in obese patients can lead to acute respiratory failure. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 16, 2017 Category: Surgery Authors: A.C. Valezi, B.G.F. Melo, M. Liberatti, A.C. Marson, A.G. Lopes Tags: Paired papers Source Type: research

Firing a loaded gun during sleep in an elderly man with a “perfect storm” of risk factors including severe obstructive sleep apnea
ConclusionsIn this case, there was a “perfect storm” of sleep and psychological risk factors that converged to strongly promote precipitous arousals with sleep-related violence in a patient with documented sleep motor dyscontrol. Primary care physicians, including geriatric specialists, should question patients and their spouses ab out any symptoms of sleep disorders. (Source: Sleep and Breathing)
Source: Sleep and Breathing - October 16, 2017 Category: Respiratory Medicine Source Type: research

Sleep disorders and health-related quality of life in patients with interstitial lung disease
ConclusionsIn this sample of patients with IPF and sarcoidosis, obstructive sleep apnea is common at least in a mild degree of severity. The SF-36 questionnaire may be a useful tool for the evaluation of the quality of life in these patients. (Source: Sleep and Breathing)
Source: Sleep and Breathing - October 16, 2017 Category: Respiratory Medicine Source Type: research

Adult case of acute flaccid paralysis with enterovirus D68 detected in the CSF
We report a 28-year-old Japanese woman admitted to our hospital with distal muscular weakness after experiencing upper respiratory symptoms and subsequently diagnosed with AFP. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 16, 2017 Category: Neurology Authors: Kimura, K., Fukushima, T., Katada, N., Shimizu, H., Nakamura, T., Fujimoto, T., Hanaoka, N., Tanaka-Taya, K., Makino, K. Tags: MRI, All Infections, All Clinical Neurology, Viral infections, Spinal cord infarction Case Source Type: research

High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis
ConclusionsIn patients with acute hypoxemic respiratory failure HFNC was not associated with a difference in mortality compared to NIV or standard oxygen. Secondary outcomes including dyspnea, tolerance, and safety were not systematically reported. Residual heterogeneity and variable reporting of secondary outcomes limit the conclusions that can be made in this review. Prospective trials designed to evaluate the efficacy and safety of HFNC in patients with acute hypoxemic respiratory failure are required. (Source: Systematic Reviews)
Source: Systematic Reviews - October 16, 2017 Category: International Medicine & Public Health Source Type: research

Home supply of emergency oral steroids and reduction in asthma healthcare utilization
Abstract ObjectiveTo determine if children with moderate‐to‐severe persistent asthma have decreased healthcare utilization after receiving a prescription and instructions to use an at home emergency supply of oral steroids during asthma exacerbations. MethodsA quasi‐experimental design study with a historical control from retrospective chart review was performed for patients aged 2‐18 years seen in a tertiary care pediatric pulmonary clinic for moderate to severe persistent asthma. Baseline utilization of the emergency department, inpatient hospital, and pediatric intensive care unit for asthma exacerbations was co...
Source: Pediatric Pulmonology - October 16, 2017 Category: Respiratory Medicine Authors: Lisa M. Sarzynski, Tiffany Turner, David R. Stukus, Elizabeth Allen Tags: ORIGINAL ARTICLE: ASTHMA Source Type: research

Levels of exhaled carbon monoxide measured during an intervention program predict 1-year smoking cessation: a retrospective observational cohort study
npj Primary Care Respiratory Medicine, Published online: 16 October 2017; doi:10.1038/s41533-017-0060-8 (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - October 16, 2017 Category: Primary Care Authors: Huei-Guan Shie Sheng-Wei Pan Wen-Kuang Yu Wei-Chih Chen Li-Ing Ho Hsin-Kuo Ko Source Type: research

The Fortuitous Discovery of the Olin EILOBI Breathing Techniques: A Case Study
Exercise-induced laryngeal obstruction (EILO) is the term for the condition previously named vocal cord dysfunction and paradoxical vocal fold motion. It is defined by glottic or supraglottic obstruction during periods of intense exercise. Not all patients respond to conventional therapy with speech-language pathology, behavioral health interventions, and treatment of contributing conditions. In this edition of Journal of Voice, the authors describe a novel series of respiratory retraining techniques, now called Olin EILOBI (EILO biphasic inspiratory) breathing techniques, specifically designed for athletes with EILO. (Sou...
Source: Journal of Voice - October 16, 2017 Category: ENT & OMF Authors: Sarah Graham, Emily Deardorff, Kristina Johnston, J. Tod Olin Source Type: research

Choanal Atresia: Birth Without Breath
AbstractBilateral Choanal atresia is a medical emergency. Corrective surgery is the mainstay of the treatment. Hegar ’s dilator was used in all cases to break the bony/membranous atretic plate. The 22 cases of choanal atresia all operated by the first author were included in this study. Eight cases were 1–5 year old with bilateral choanal atresia and all required immediate surgery as they had repeated attacks of respiratory distress and cycle of cyanosis. Eight cases were of CHARGE Syndrome. All the cases were operated under general anaesthesia. Hegar’s dilators were used and nasal stents were placed...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - October 16, 2017 Category: ENT & OMF Source Type: research

Role of serum albumin as a nanoparticulate carrier for nose ‐to‐brain delivery of R‐flurbiprofen: implications for the treatment of Alzheimer's disease
ConclusionsSerum albumin‐based nanoparticles administered via the nasal route may be a viable approach in delivering therapeutic agents to the brain to alleviate mitochondrial dysfunction in AD. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - October 16, 2017 Category: Drugs & Pharmacology Authors: Ling Rong Wong, Paul C. Ho Tags: Research Paper Source Type: research

The Olin EILOBI Breathing Techniques: Description and Initial Case Series of Novel Respiratory Retraining Strategies for Athletes with Exercise-Induced Laryngeal Obstruction
Exercise-induced laryngeal obstruction (EILO), the condition previously known as paradoxical vocal fold motion and vocal cord dysfunction, is characterized by inappropriate glottic or supraglottic obstruction during high-intensity exercise, causing exertional dyspnea, frequently with stridor. EILO is definitively diagnosed through upper-airway visualization during a characteristic episode. Although respiratory retraining is a primary therapy for EILO, many patients report symptom persistence despite adequate performance of traditional techniques. (Source: Journal of Voice)
Source: Journal of Voice - October 16, 2017 Category: ENT & OMF Authors: Kristina L. Johnston, Hannah Bradford, Heather Hodges, Camille M. Moore, Emily Nauman, J. Tod Olin Source Type: research

Pulmonary schistosomiasis mimicking IgG4 ‐related lung disease
IgG4‐related disease (IgG4‐RD) is a systemic fibroinflammatory disease characterized by tumefactive lesions in various organ systems, including the lungs. Clinical and radiological manifestations of IgG4‐RD are relatively non‐specific, and we report a case highlighting the importance of histopathological confirmation in cases of suspected IgG4‐related lung disease. A 44‐year‐old male with significantly elevated serum IgG4 levels, patchy consolidation on thoracic CT imaging, and cough was referred with suspected IgG4‐related lung disease. However, surgical lung biopsy revealed an unexpected diagnosis of pulm...
Source: Respirology Case Reports - October 16, 2017 Category: Respiratory Medicine Authors: Timothy Baird, Caroline L Cooper, Richard Wong, Naomi Runnegar, Gregory Keir Tags: Case Report Source Type: research

Muscle specific differences in expression and phosphorylation of the Janus kinase 2/ Signal Transducer and Activator of Transcription 3 following long ‐term mechanical ventilation and immobilization in rats
ConclusionThe JAK2/STAT3 pathway was differentially activated in plantaris, intercostal, and diaphragm muscles in response to the ICU condition. Thus, JAK2/STAT3 inhibitors may provide an attractive pharmacological intervention strategy in immobilized ICU patients, but further experimental studies are required in the study of muscle‐specific effects on muscle mass and function in response to both short‐ and long‐term exposure to the ICU condition prior to the translation into clinical research and practice.This article is protected by copyright. All rights reserved. (Source: Acta Physiologica)
Source: Acta Physiologica - October 15, 2017 Category: Physiology Authors: Heba Salah, Wen Fury, Jesper Gromada, Yu Bai, Tamar Tchkonia, James L. Kirkland, Lars Larsson Tags: Regular Paper Source Type: research

Recognizing Workplace Factors Contributing to Interstitial Lung Disease.
PMID: 29028374 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2017 Category: Respiratory Medicine Authors: Harber P Tags: Am J Respir Crit Care Med Source Type: research

Health Disparities in Patients with Pulmonary Arterial Hypertension: A Blueprint for Action. An Official American Thoracic Society Statement.
CONCLUSIONS: At present, there are few studies that address health disparities in PAH. Given the potential adverse impact of health disparities, we recommend that research efforts be undertaken to address the topics discussed in the document. Awareness of health disparities will likely improve advocacy efforts, public health policy and the quality of care of vulnerable populations with PAH. PMID: 29028375 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2017 Category: Respiratory Medicine Authors: Talwar A, Garcia JGN, Tsai H, Moreno M, Lahm T, Zamanian RT, Machado R, Kawut SM, Selej M, Mathai S, D'Anna LH, Sahni S, Rodriquez EJ, Channick R, Fagan K, Gray M, Armstrong J, Rodriguez Lopez J, de Jesus Perez V, Pulmonary Circulation Assembly Tags: Am J Respir Crit Care Med Source Type: research