Beneficial Effects of Vaccination on Cardiovascular Events: Myocardial Infarction, Stroke, Heart Failure
Influenza and pneumococcal infections have been suggested to be potential risk factors for causing adverse cardiovascular events, especially in high-risk patients. Vaccination against respiratory infections in patients with established cardiovascular disease (CVD) could serve as a potential cost-effective intervention to improve their clinical outcomes and cardiac societies have encouraged it. Previous studies have shown that influenza vaccination reduce mortality, acute coronary syndromes and hospitalization in patients with coronary heart disease (CHD) and/or heart failure (HF). However, there is a paucity of randomized ...
Source: Cardiology - November 15, 2018 Category: Cardiology Source Type: research

Human COX7A2L Regulates Complex III Biogenesis and Promotes Supercomplex Organization Remodeling without Affecting Mitochondrial Bioenergetics
Publication date: 13 November 2018Source: Cell Reports, Volume 25, Issue 7Author(s): Teresa Lobo-Jarne, Eva Nývltová, Rafael Pérez-Pérez, Alba Timón-Gómez, Thibaut Molinié, Austin Choi, Arnaud Mourier, Flavia Fontanesi, Cristina Ugalde, Antoni BarrientosSummaryThe mitochondrial respiratory chain is organized in a dynamic set of supercomplexes (SCs). The COX7A2L protein is essential for mammalian SC III2+IV assembly. However, its function in respirasome (SCs I+III2+IVn) biogenesis remains controversial. To unambiguously determine the COX7A2L role, we ...
Source: Cell Reports - November 14, 2018 Category: Cytology Source Type: research

Intrauterine Growth Restriction and Hyperoxia as a Cause of White Matter Injury
Intrauterine growth restriction (IUGR) is estimated to occur in 5% of pregnancies, with placental insufficiency being the most common cause in developed countries. While it is known that white matter injury occurs in premature infants, the extent of IUGR on white matter injury is less defined in term infants. We used a novel murine model that utilizes a thromboxane A2 (TXA2) analog (U46619), a potent vasoconstrictor, to induce maternal hypertension and mimic human placental insufficiency-induced IUGR to study the white matter. We also investigated the role of hyperoxia as an additional risk factor for white matter injury, ...
Source: Developmental Neuroscience - November 14, 2018 Category: Neuroscience Source Type: research

Two Independent Predictors of Nightmares in Posttraumatic Stress Disorder
Conclusions:Elevated REI and lower sleep period RSA were independently predictive of NM/DD. The former result is consistent with studies showing that sleep-disordered breathing (SDB) is a factor in NM/DD, and that continuous positive airway pressure (CPAP) can reduce these symptoms in patients with comorbid PTSD and SDB. The latter result implicates dysregulated arousal modulation during sleep in trauma-related NM/DD. It is consistent with findings that NM/DD are reported in patients without SDB and can persist in patients with comorbid PTSD and SDB even when CPAP successfully remediates SDB.Citation:Miller KE, Jamison AL,...
Source: Journal of Clinical Sleep Medicine : JCSM - November 14, 2018 Category: Sleep Medicine Source Type: research

Predictors of Obstructive Sleep Apnea on a Home Sleep Apnea Test After a Negative Attended Polysomnography
Conclusions:This retrospective study illustrates that there are patients for whom PSG gave a false-negative study. Patients who had negative PSG and positive HSAT are more likely to be older and have the diagnosis of hypertension. Sleep physicians may consider repeat testing with HSAT in patients with a negative PSG and clinical symptoms of OSA.Commentary:A commentary on this article appears in this issue on page 1839.Citation:Lipatov K, Hayek A, Ghamande S, Boethel C, Chen W, Jones S. Predictors of obstructive sleep apnea on home sleep apnea test after a negative attended polysomnography.J Clin Sleep Med. 2018;14(11):1889...
Source: Journal of Clinical Sleep Medicine : JCSM - November 14, 2018 Category: Sleep Medicine Source Type: research

Thermodynamic buffering, stable non-equilibrium and establishment of the computable structure of plant metabolism
Publication date: Available online 13 November 2018Source: Progress in Biophysics and Molecular BiologyAuthor(s): Abir U. Igamberdiev, Leszek A. KleczkowskiAbstractThe equilibria of coenzyme nucleotides and substrates established in plant cells generate simple rules that govern the plant metabolome and provide optimal conditions for the non-equilibrium fluxes of major metabolic processes such as ATP synthesis, CO2 fixation, and mitochondrial respiration. Fast and abundant enzymes, such as adenylate kinase, carbonic anhydrase or malate dehydrogenase, provide constant substrate flux for these processes. These “bufferin...
Source: Progress in Biophysics and Molecular Biology - November 14, 2018 Category: Molecular Biology Source Type: research

Multiple-strain probiotics appear to be more effective in improving the growth performance and health status of white shrimp, Litopenaeus vannamei, than single probiotic strains
Publication date: January 2019Source: Fish & Shellfish Immunology, Volume 84Author(s): Yu-Chu Wang, Shao-Yang Hu, Chiu-Shia Chiu, Chun-Hung LiuAbstractThe probiotic efficiencies of the mixed probiotics containing Lactobacillus pentosus BD6, Lac. fermentum LW2, Bacillus subtilis E20, and Saccharomyces cerevisiae P13 for shrimp growth and health status improvement were better than those when using single probiotics. The probiotic mixture at a level of 108 colony-forming units (cfu) (kg diet)−1 and the diets containing BD6 and E20 at 109 cfu (kg diet)−1 significantly improved the growth and health status o...
Source: Fish and Shellfish Immunology - November 14, 2018 Category: Biology Source Type: research

Zeta potential changes of Saccharomyces cerevisiae during fermentative and respiratory cycles
Publication date: 1 February 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 174Author(s): Lucía M. Lavaisse, Axel Hollmann, Mónica A. Nazareno, Edgardo A. DisalvoAbstractSaccharomyces cerevisiae is a type of yeast, widely used in diverse biotechnological food-beverage processes. Although the performance of an industrial fermentation process depends largely on the number of cells, it is necessary to consider the physiological state of the cultures. In this context, the aim of this study was to determine in a yeast culture how factors such as growth conditions affect surface properties at the differ...
Source: Colloids and Surfaces B: Biointerfaces - November 14, 2018 Category: Biochemistry Source Type: research

Annual epidemics of acute respiratory infection caused by respiratory syncytial virus in adults
Publication date: Available online 13 November 2018Source: Revista Clínica Española (English Edition)Author(s): J. Reina, E. del Barrio, J. Murillas (Source: Revista Clinica Espanola)
Source: Revista Clinica Espanola - November 14, 2018 Category: Internal Medicine Source Type: research

Effectiveness of influenza vaccination on influenza-associated hospitalisations over time among children in Hong Kong: a test-negative case-control study
Publication date: Available online 12 November 2018Source: The Lancet Respiratory MedicineAuthor(s): Shuo Feng, Susan S Chiu, Eunice L Y Chan, Mike Y W Kwan, Joshua S C Wong, Chi-Wai Leung, Yiu Chung Lau, Sheena G Sullivan, J S Malik Peiris, Benjamin J CowlingSummaryBackgroundThe protection conferred by influenza vaccination is generally thought to last less than a year, necessitating annual revaccination. However, the speed with which influenza vaccine effectiveness might decline during a year is unknown, which is of particular importance for locations with year-round influenza activity. We aimed to assess how influenza v...
Source: The Lancet Respiratory Medicine - November 14, 2018 Category: Respiratory Medicine Source Type: research

Perioperative mortality and morbidity after sublobar versus lobar resection for early-stage non-small-cell lung cancer: post-hoc analysis of an international, randomised, phase 3 trial (CALGB/Alliance 140503)
Publication date: Available online 12 November 2018Source: The Lancet Respiratory MedicineAuthor(s): Nasser K Altorki, Xiaofei Wang, Dennis Wigle, Lin Gu, Gail Darling, Ahmad S Ashrafi, Rodney Landrenau, Daniel Miller, Moishe Liberman, David R Jones, Robert Keenan, Massimo Conti, Gavin Wright, Linda J Veit, Suresh S Ramalingam, Mohamed Kamel, Harvey I Pass, John D Mitchell, Thomas Stinchcombe, Everett VokesSummaryBackgroundIncreased detection of small-sized, peripheral, non-small-cell lung cancer has renewed interest in sublobar resection instead of lobectomy, the traditional standard of care for early-stage lung cancer. W...
Source: The Lancet Respiratory Medicine - November 14, 2018 Category: Respiratory Medicine Source Type: research

How long are children protected by influenza vaccination?
Publication date: Available online 12 November 2018Source: The Lancet Respiratory MedicineAuthor(s): Lien Anh Ha Do, Kim Mulholland (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 14, 2018 Category: Respiratory Medicine Source Type: research

A new low represents a new high in surgical safety
Publication date: Available online 12 November 2018Source: The Lancet Respiratory MedicineAuthor(s): Daniel Boffa (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 14, 2018 Category: Respiratory Medicine Source Type: research

Concerns over low uptake of flu vaccination in social care
Publication date: Available online 12 November 2018Source: The Lancet Respiratory MedicineAuthor(s): Talha Khan Burki (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 14, 2018 Category: Respiratory Medicine Source Type: research

Pneumonia is a neglected problem: it is now time to act
Publication date: Available online 12 November 2018Source: The Lancet Respiratory MedicineAuthor(s): Stefano Aliberti, Charles S Dela Cruz, Giovanni Sotgiu, Marcos I Restrepo (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 14, 2018 Category: Respiratory Medicine Source Type: research

Corrections
Publication date: Available online 13 November 2018Source: The Lancet Respiratory MedicineAuthor(s): (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 14, 2018 Category: Respiratory Medicine Source Type: research

Combined effects of intermittent hyperoxia and intermittent hypercapnic hypoxia on respiratory control in neonatal rats
Publication date: Available online 12 November 2018Source: Respiratory Physiology & NeurobiologyAuthor(s): Ryan W. Bavis, Alexandra H. Millström, Song M. Kim, Carolyn A. MacDonald, Caitlin A. O’Toole, Kendra Asklof, Amy B. McDonoughAbstractChronic exposure to intermittent hyperoxia causes abnormal carotid body development and attenuates the hypoxic ventilatory response (HVR) in neonatal rats. We hypothesized that concurrent exposure to intermittent hypercapnic hypoxia would influence this plasticity. Newborn rats were exposed to alternating bouts of hypercapnic hypoxia (10% O2/6% CO2) and hyperoxia (30-40% O...
Source: Respiratory Physiology and Neurobiology - November 14, 2018 Category: Respiratory Medicine Source Type: research

Mice-to-men comparison of inhaled drug-aerosol deposition and clearance
Publication date: Available online 13 November 2018Source: Respiratory Physiology & NeurobiologyAuthor(s): Arun V. Kolanjiyil, Clement Kleinstreuer, Nicole C. Kleinstreuer, Wellington Pham, Ruxana T. SadikotAbstractPart of the effective prediction of the pharmacokinetics of drugs (or toxic particles) requires extrapolation of experimental data sets from animal studies to humans. As the respiratory tracts of rodents and humans are anatomically very different, there is a need to study airflow and drug-aerosol deposition patterns in lung airways of these laboratory animals and compare them to those of human lungs. As a fi...
Source: Respiratory Physiology and Neurobiology - November 14, 2018 Category: Respiratory Medicine Source Type: research

Treatment of chronic tuberculous empyema by intrapleural injection of anhydrous ethanol
ConclusionSurgical operation is the main treatment of chronic tuberculous empyema, which has a high cost and large injury, and many patients do not accept this treatment. In this study, intrapleural injection of anhydrous ethanol could achieve the purpose of eliminating the pus cavity, which is particularly suitable for patients who cannot tolerate surgery or are unwilling to undergo surgical treatment. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - November 14, 2018 Category: Respiratory Medicine Source Type: research

The clinical benefits of immune checkpoint inhibitor for thymic carcinomas ∼experience of single public hospital in Japan∼
Publication date: Available online 13 November 2018Source: Respiratory Medicine Case ReportsAuthor(s): Naohiro Uchida, Kohei Fujita, Misato Okamura, Koichi Nakatani, Tadashi MioAbstractThymic carcinomas is rare and highly aggressive carcinoma. Most patients with them are diagnosed as being at surgically unresectable stages due to it. There are several reports which showed the effect of chemotherapy, however, it is controversial. Recently, immune checkpoint inhibitors have changed conventional chemotherapy due to their effect against various types of cancers. We administered nivolumab, anti-Programmed Cell Death (PD)-1 anti...
Source: Respiratory Medicine Case Reports - November 14, 2018 Category: Respiratory Medicine Source Type: research

Regional disparity in outcomes among patients hospitalized for Takotsubo cardiomyopathy in the United States✰
ConclusionSignificant geographic variation exists in the cost of hospitalization and in-hospital mortality of TTCM across the US. Understanding this variation requires a detailed understanding of the processes of care and identification of effective strategies to eliminate these disparities. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - November 14, 2018 Category: Respiratory Medicine Source Type: research

Prevalence of Arnold nerve reflex in subjects with and without chronic cough: Relevance to Cough Hypersensitivity Syndrome
ConclusionsThe greater than 11-fold prevalence of the Arnold nerve reflex in adults with chronic cough compared with healthy volunteers and adults with respiratory disease but without chronic cough, supports the concept of the Cough Hypersensitivity Syndrome (CHS), in which vagal hypersensitivity is proposed to underlie chronic refractory cough. The absence of increased prevalence among children with chronic cough suggests that CHS is an acquired condition, perhaps triggered by viral respiratory infection or other environmental factor. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - November 14, 2018 Category: Respiratory Medicine Source Type: research

Confocal Laser Endomicroscopy as a Guidance Tool for Transbronchial Lung Cryobiopsies in Interstitial Lung Disorder
Conclusions: CLE seems a promising alternative to fluoroscopy as a guidance tool for TBCB procedures.Respiration (Source: Respiration)
Source: Respiration - November 14, 2018 Category: Respiratory Medicine Source Type: research

Nebulized Antibiotics in Acute Exacerbation of Non-Cystic Fibrosis Bronchiectasis: Shifting the Goal Posts or a Post Too Far?
Respiration (Source: Respiration)
Source: Respiration - November 14, 2018 Category: Respiratory Medicine Source Type: research

Prognostic Factors in Adult Patients with Non-Cystic Fibrosis Bronchiectasis
ConclusionsOlder age, lower FEV1 % of predicted, and lower MEP were independently linked to unfavorable outcomes. FACED and BSI were not accurate in predicting mortality in our cohort. (Source: Lung)
Source: Lung - November 14, 2018 Category: Respiratory Medicine Source Type: research

Serum irisin is upregulated in patients affected by amyotrophic lateral sclerosis and correlates with functional and metabolic status
AbstractIntroductionThe progression of amyotrophic lateral sclerosis (ALS) leads to a decline of the nutritional status that represents an independent prognostic factor for survival. Recent studies recognize the muscle tissue as an endocrine organ able to release several molecules, called myokines. Among them, irisin seems to be involved in the regulation of metabolism, body weight and development and function of the nervous system.Objectives(1) To evaluate irisin serum levels in patients with ALS, with comparison to healthy subjects; (2) to assess the possible association of circulating irisin levels of ALS patients with ...
Source: Journal of Neurology - November 14, 2018 Category: Neurology Source Type: research

The effect of aerosolized indomethacin on lung inflammation and injury in a rat model of blunt chest trauma
Conclusion: Aerosolized indomethacin has a protective effect against alveloar tissue permeability and inflammatory response induced by BCT. PMID: 30418008 [PubMed - in process] (Source: Canadian Journal of Surgery)
Source: Canadian Journal of Surgery - November 14, 2018 Category: Surgery Authors: Kao RLK, Huang WH, Martin CMM, Rui TR Tags: Can J Surg Source Type: research

Lung function improvements in emphysema following pneumonia.
We describe two cases of patients with emphysema who, in the lead up to hyperinflation intervention, developed pneumonia with significant physiological, anatomical, functional and quality of life improvement observed following. This directly goes against the natural history of both disease processes, demonstrating the benefit resulting from infective autobullectomy. PMID: 30416955 [PubMed] (Source: Respiratory Care)
Source: Respiratory Care - November 14, 2018 Category: Respiratory Medicine Authors: Kayani K, Mahadeva R, Stinchcombe S, Rutter M, Babar J, Fuld J Tags: Respir Med Case Rep Source Type: research

Effectiveness of ECMO for burn-related acute respiratory distress syndrome
ConclusionMortality in burn patients with ARDS who are managed with ECMO is extremely low. Careful selection and timely intervention with ECMO contributed to good clinical outcomes. (Source: Burns)
Source: Burns - November 14, 2018 Category: Dermatology Source Type: research

Phytochemical analysis of Pathyashadangam kwath and its standardization by HPLC and HPTLC
ConclusionThe characterization parameters presented in this paper may serve as standard reference for quality control analysis of Pathyashadangam kwath. (Source: Journal of Ayurveda and Integrative Medicine)
Source: Journal of Ayurveda and Integrative Medicine - November 14, 2018 Category: Complementary Medicine Source Type: research

Fluoxetine modulates spontaneous and conditioned behaviors to carbon dioxide (CO2) inhalation and alters forebrain-midbrain neuronal activation
Publication date: Available online 12 November 2018Source: NeuroscienceAuthor(s): Katherine M.J. McMurray, Jeffrey R. Strawn, Renu SahAbstractPanic disorder (PD), a prevalent anxiety disorder, is characterized by unexpected panic attacks, persistent anxiety and avoidance of panic contexts. Selective serotonin reuptake inhibitors (SSRIs) are effective in treating PD; however, the mechanisms underlying SSRI efficacy are poorly understood. Using CO2-inhalation, a PD-relevant translational paradigm, we examined the effect of chronic SSRI (fluoxetine) treatment on unconditioned and context conditioned defensive behaviors, as we...
Source: Neuroscience - November 14, 2018 Category: Neuroscience Source Type: research

[Being diagnosed with COPD: A qualitative study of real life experience].
CONCLUSION: The announcement of the disease did not always appear to have been of good quality. Ideally, the diagnosis of COPD should be conveyed to people after its identification in a dedicated consultation, combined with better information and a proposal for psychological support. PMID: 30415820 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - November 14, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Critical Care in the Pediatric Emergency Department
In caring for critically ill children, recognition and management often begins in the pediatric emergency department. A seamless transition in care is needed to ensure appropriate care to the sickest of children. This review covers the management of critically ill children in the pediatric emergency department beyond the initial stabilization for conditions such as acute respiratory failure and pediatric acute respiratory distress syndrome, traumatic brain injury, status epilepticus, congenital heart disease, and metabolic emergencies. (Source: Pediatric Clinics of North America)
Source: Pediatric Clinics of North America - November 14, 2018 Category: Pediatrics Authors: Kristen A. Smith, Heidi R. Flori Source Type: research

Cost-effectiveness of the SQ HDM SLIT-tablet for the treatment of allergic asthma in three Eastern European Countries.
Conclusion.The SQ HDM SLIT-tablet is a cost-effective treatment option for people with HDM AA in three different health care settings in Eastern Europe. PMID: 30417636 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - November 14, 2018 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Can a temporary increase in corticosteroid dosage reduce asthma exacerbations?
Authors: Sutherland LG, Harrison TW PMID: 30415575 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - November 14, 2018 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Feasibility of the Allergy Questionnaire for Athletes (AQUA ©) in pediatric age
This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)
Source: Pediatric Allergy and Immunology - November 14, 2018 Category: Allergy & Immunology Authors: Salvatore Fasola, Marianna Bellafiore, Ilaria Baiardini, Matteo Bonini, Stefano Del Giacco, Giuliana Ferrante, Stefania La Grutta Tags: Letter to the Editor Source Type: research

Clinical and laboratory characteristics of patients with toxocariasis encountered at a tertiary care centre in North India
This study aims to analyse the clinical and laboratory characteristics of Toxocara-infected patients and assessment of response to standard treatment with review of literature. The clinical details of patients with Toxocara serology positive for IgG antibodies by ELISA in 5 years (2013–2017) were retrospectively analysed. A total of 29 patients with clinical features and serology suggestive of Toxocara infection were evaluated. A complete history of 14 patients was available for the analysis. Majority (13/14; 96.5%) of cases were children <15 years, males (79%) and belonged to lower socioeconomic status (...
Source: Indian Journal of Medical Microbiology - November 14, 2018 Category: Microbiology Authors: Jutang Babat Ain Tiewsoh Sumeeta Khurana Abhishek Mewara Rakesh Sehgal Ankita Singh Source Type: research

Comparing the profile of respiratory fungal pathogens amongst immunocompetent and immunocompromised hosts, their susceptibility pattern and correlation of various opportunistic respiratory fungal infections and their progression in relation to the CD4 & #43;T-cell counts
Conclusion: Patterns of invasive fungal infections are changing in many ways. In the midst of these evolving trends, IFI of the respiratory tractcontinue to remain important causes of morbidity and mortality. Diagnostic tools can be adequately used only if the treating physician is aware of the propensity of patients to acquire a fungal infection. Thus, continuous awareness and education is crucial for successful management of patients. Judicious use of antifungal medications as prophylactic measures must be employed, particularly in the critically ill and patients of HIV. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - November 14, 2018 Category: Microbiology Authors: Asma Husein Roohani Nazish Fatima Mohammad Shameem Haris Manzoor Khan Parvez Anwar Khan Anees Akhtar Source Type: research

Efficacy of vitamin D replacement therapy in restless legs syndrome: a randomized control trial
ConclusionsThe results suggest that vitamin D supplementation does not improve restless legs syndrome symptoms.Clinical trial registration numberClinicalTrials.gov: NCT02256215 (available from:https://clinicaltrials.gov/ct2/show/NCT02256215). (Source: Sleep and Breathing)
Source: Sleep and Breathing - November 14, 2018 Category: Respiratory Medicine Source Type: research

Respiratory muscle weakness increases dead ‐space ventilation ratio aggravating ventilation–perfusion mismatch during exercise in patients with chronic heart failure
ConclusionRespiratory muscle weakness was associated with an increased dead ‐space ventilation ratio aggravating ventilation–perfusion mismatch during exercise in patients with CHF. (Source: Respirology)
Source: Respirology - November 14, 2018 Category: Respiratory Medicine Authors: Nobuaki Hamazaki, Takashi Masuda, Kentaro Kamiya, Ryota Matsuzawa, Kohei Nozaki, Emi Maekawa, Chiharu Noda, Minako Yamaoka ‐Tojo, Junya Ako Tags: Original Article Source Type: research

Respiratory syncytial virus vaccine: where are we now and what comes next?
. (Source: Expert Opinion on Biological Therapy)
Source: Expert Opinion on Biological Therapy - November 14, 2018 Category: Drugs & Pharmacology Authors: Asif Noor Leonard R. Krilov Source Type: research

Age-dependent outcomes in asymptomatic umbilical hernia repair
AbstractPurposeUmbilical hernias are common in young children. Many resolve spontaneously by age four with very low risk of symptoms or incarceration. Complications associated with surgical repair of asymptomatic umbilical hernias have not been well elucidated. We analyzed data from one hospital to test the hypothesis that repair at younger ages is associated with increased complication rates.MethodsA retrospective chart review of all umbilical hernia repairs performed during 2007 –2015 was conducted at a tertiary care children’s hospital. Patients undergoing repairs as a single procedure for asymptomatic herni...
Source: Pediatric Surgery International - November 14, 2018 Category: Surgery Source Type: research

Identification of Phenotypes in People with COPD: Influence of Physical Activity, Sedentary Behaviour, Body Composition and Skeletal Muscle Strength
AbstractIntroductionPeople with chronic obstructive pulmonary disease (COPD) present high prevalence of physical inactivity that leads to a negative effect on health-related quality of life (HRQoL). The present study investigated COPD phenotypes according to their levels of physical activity and sedentary behaviour, as well as body composition and skeletal muscle strength.MethodsThis is an observational and cross-sectional study. Anthropometric data and COPD clinical control were collected and all participants underwent assessments of lung function, HRQoL, dyspnoea, levels of physical activity and sedentary behaviour, body...
Source: Lung - November 14, 2018 Category: Respiratory Medicine Source Type: research

Sero-prevalence and associated risk factors of Mycoplasma hyopneumoniae infection in Kailali and Kanchanpur District of Far Western, Nepal
AbstractRespiratory diseases cause severe distress leading to serious effects on production characteristics of pigs.Mycoplasma hyopneumoniae (Mh) is one of the primary contributors of porcine respiratory disease complex (PRDC). A cross-sectional study was conducted to determine the sero-prevalence and associated risk factors of enzootic pneumonia (EP) caused by Mh in Kailali and Kanchanpur Districts of Nepal. The herd level information of the site was gathered using standardized questionnaire survey. A total of 184 porcine serum samples were collected randomly and tested by using competitive ELISA targeting anti-Mh antibod...
Source: Comparative Clinical Pathology - November 14, 2018 Category: Pathology Source Type: research

The Pathophysiology of Respiratory Failure: Control of Breathing, Respiratory Load, and Muscle Capacity
The purpose of this review is to provide an overview on how interactions between control of breathing, respiratory load, and muscle function may lead to respiratory failure. The mechanisms involved vary according to the underlying pathology, but respiratory failure is most often the result of an imbalance between the muscular pump and the mechanical load placed upon it. Changes in respiratory drive and response to CO2 seem to be important contributors to the pathophysiology of respiratory failure. Inspiratory muscle dysfunction is also frequent but is not a mandatory prerequisite to respiratory failure since increased load...
Source: Respiration - November 13, 2018 Category: Respiratory Medicine Source Type: research

Antipsychotics May Increase Risk of Pneumonia, Meta-Analysis Suggests
Patients who take antipsychotics may be at an increased risk of pneumonia, according to asystematic review and meta-analysis published in theJournal of Psychopharmacology.After performing a search of several databases, Olubanke Dzahini, B.Pharm., M.Sc., of the Institute of Pharmaceutical Science at King ’s College London and colleagues included 14 studies with a total of 206,899 patients in the meta-analysis. By compiling, comparing, and contrasting data from these studies, the researchers sought to assess the overall risk of pneumonia in patients who took first- or second-generation antipsychoti cs compared with tho...
Source: Psychiatr News - November 13, 2018 Category: Psychiatry Tags: first-generation antipsychotics Journal of Psychopharmacology Olubanke Dzahini pneumonia second-generation antipsychotics Source Type: research

Profound Vasoconstriction Implications for Percutaneous Arterial Access
IN the management of severe respiratory failure, veno-venous extracorporeal membrane oxygenation is an increasingly used therapy that presents a unique challenge for anesthesiologists.1 Veno-arterial-venous extracorporeal membrane oxygenation is emerging as a strategy to treat refractory respiratory failure with coexisting cardiogenic shock.2 This image demonstrates profound constrictive effects of high-dose vasopressor therapy on arterial caliber and implications for percutaneous arterial access. (Source: Anesthesiology)
Source: Anesthesiology - November 13, 2018 Category: Anesthesiology Source Type: research

Prediction Score for Postoperative Neurologic Complications after Brain Tumor Craniotomy A Multicenter Observational Study
Conclusions The validation of prediction scores is the first step toward on-demand intensive care unit admission. Further research is needed to improve the score ’s performance before routine use. (Source: Anesthesiology)
Source: Anesthesiology - November 13, 2018 Category: Anesthesiology Source Type: research

Individual Positive End-expiratory Pressure Settings Optimize Intraoperative Mechanical Ventilation and Reduce Postoperative Atelectasis
Editor ’s PerspectiveWhat We Already Know about This TopicIn patients with adult respiratory distress syndrome, physiologic tidal volume and positive end-expiratory pressure (PEEP) are protectiveIn patients without lung diseases undergoing mechanical ventilation under general anesthesia, optimal PEEP is unknownWhat This Article Tells Us That Is NewOptimal positive end-expiratory pressure (PEEP) values for patients with normal lungs and under general anesthesia vary significantlyApplication of individualized optimal PEEP intraoperatively not only reduces driving pressure and improves respiratory compliance and oxygena...
Source: Anesthesiology - November 13, 2018 Category: Anesthesiology Source Type: research

Community-based survey as a basis for evidence-based public health: children living in Upper Silesian Industrial Zone.
Authors: Skrzypek M, Kowalska M, Kobza J, Wypych A, Czech EM, Niewiadomska E, Bała MM Abstract OBJECTIVE: The aim of the study was to estimate changes in the prevalence of respiratory diseases and disorders between 2003/2004 and 2011/2012 in 13-16 years old children living in Bytom, one of the biggest cities in the Silesia agglomeration and provide the evidence for local policy makers. METHODS: Data from two cross-sectional surveys, based on the Polish version of the International Study of Allergy and Asthma in Childhood (ISAAC) questionnaire, conducted in 2003/2004 and 2011/2012 was used. Response rate in the...
Source: Central European Journal of Public Health - November 13, 2018 Category: International Medicine & Public Health Tags: Cent Eur J Public Health Source Type: research