COVID-19 in a patient with active tuberculosis: a rare case-report
Publication date: Available online 4 July 2020Source: Respiratory Medicine Case ReportsAuthor(s): Fahad Faqihi, Abdulrahman Alharthy, AlFateh Noor, Ahmed Balshi, Abdullah Balahmar, Dimitrios Karakitsos (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - July 4, 2020 Category: Respiratory Medicine Source Type: research

Discrepancies in preferences regarding the care of terminal-phase pneumonia in elderly patients among patients, families, and doctors: A multicenter questionnaire survey in nagasaki, Japan
Publication date: Available online 3 July 2020Source: Respiratory InvestigationAuthor(s): Takahiro Takazono, Yoshifumi Imamura, Kaoru Kawakami, Naoya Yamasaki, Hiroyoshi Shimizu, Katsuhiro Usuki, Maiko Kiyohara, Tatsuro Hirayama, Masato Tashiro, Naoki Hosogaya, Tomomi Saijo, Kazuko Yamamoto, Taiga Miyazaki, Katsunori Yanagihara, Koichi Izumikawa, Hiroshi Mukae (Source: Respiratory Investigation)
Source: Respiratory Investigation - July 4, 2020 Category: Respiratory Medicine Source Type: research

COVID-19 and venous thromboembolism: current insights and prophylactic strategies.
Authors: Ambrosino P, Di Minno A, Maniscalco M, Di Minno MND Abstract The rapidly increasing number of studies on the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) indicate that this viral agent can cause the coronavirus disease 2019 (COVID-19), a syndrome with a wide spectrum of clinical presentations, ranging from a mild disease with flu-like symptoms to a life-threatening condition that requires specialized management at Intensive Care Units (ICU). Critical patients with COVID-19 have a high risk of thromboembolic complications, as expressed by a Padua prediction score always ≥4. Moreover...
Source: Annals of Medicine - July 4, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

First-time handling of different inhalers by chronic obstructive lung disease patients.
Authors: Harb HS, Laz NI, Rabea H, Abdelrahim MEA Abstract Background: There is a lack of guidance on inhaler device selection and how to individualize inhaler choice when prescribed for the first-time.Aim of the work: To compare different inhalers regarding ease of use and number of counseling attempts needed for correct handling in subjects with a first experience to such inhalers; also, to investigate if there is a correlation between total correct steps achievements and patient demographics/clinical variables.Method: An open-label, non-drug interventional, cross-over study was conducted including 180 Egyptian p...
Source: Experimental Lung Research - July 4, 2020 Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research

The comparison between pulmonary rehabilitation with music therapy and pulmonary rehabilitation alone on respiratory drive, cortisol level and asthma control in patients hospitalized with asthma exacerbation.
CONCLUSION: Passive music therapy and its effects on the mental state of patients seem to improve the efficiency of the respiratory system. The results of this experimental study demonstrate that a complementary music therapy has beneficial effects on the treatment of asthma exacerbations in adults. PMID: 32613871 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - July 4, 2020 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Pathological effects of nano-sized particles in the respiratory system
Publication date: Available online 17 June 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Richard Nho (Source: Nanomedicine: Nanotechnology, Biology and Medicine)
Source: Nanomedicine: Nanotechnology, Biology and Medicine - July 4, 2020 Category: Nanotechnology Source Type: research

Challenge and strategies of infection control in psychiatric hospitals during biological disasters-From SARS to COVID-19 in Taiwan.
Authors: Hsu ST, Chou LS, Chou FH, Hsieh KY, Chen CL, Lu WC, Kao WT, Li DJ, Huang JJ, Chen WJ, Tsai KY Abstract Psychiatric hospitals play an important role in supporting patients with mental illness to relieve symptoms and improve functioning in a physically and psychologically safe environment. However, these hospitals are also vulnerable to emerging infectious diseases. In early 2020, a psychiatric hospital and a psychiatric unit were reported to have nosocomial coronavirus disease 2019 (COVID-19) infection. A large number of patients and staff were severely impacted. This type of nosocomial infection threatens ...
Source: Asian Journal of Psychiatry - July 4, 2020 Category: Psychiatry Tags: Asian J Psychiatr Source Type: research

Expert Opinion on the Management and Follow-up of Uveitis Patients during SARS-CoV-2 Outbreak.
Authors: Stanescu-Segall D, Sales de Gauzy T, Reynolds R, Faes L, Pohlmann D, Pakzad-Vaezi K, Ting D, Saadoun D, Ambati J, Loewenstein A, Bodaghi B, de Smet MD, Touhami S Abstract INTRODUCTION: Routine medical and ophthalmic care is being drastically curtailed in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Uveitis patients require particular attention because of their theoretical risk of viral infection, in the context of therapeutic immunosuppression. AREAS COVERED: This collaborative work proposes practical management and follow-up criteria for uveitis patients in...
Source: Expert Review of Clinical Immunology - July 4, 2020 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research

Multiple Fatalities in a Family Cluster of COVID-19 With Acute Respiratory Distress Syndrome.
Conclusion: This report describes a familial cluster of fatal COVID-19 infections and suggests a potential genetic predisposition for severe disease, emphasizing the importance of investigating family clusters of severe COVID-19 infection to determine host and viral factors that may predispose to a severe disease course. Such investigations could improve our understanding of the disease and guide preventive measures for at-risk populations. PMID: 32612465 [PubMed] (Source: Ochsner Journal)
Source: Ochsner Journal - July 4, 2020 Category: General Medicine Tags: Ochsner J Source Type: research

Variability of Paranasal Sinus Pneumatization in the Absence of Sinus Disease.
Conclusion: Substantial anatomic variation exists in paranasal sinus anatomy, even among patients without sinus disease. Significant differences are found between males and females and between the left and right sides. Continued systematic research of paranasal sinus anatomy may facilitate a standard for CT sinus assessment that will aid clinician evaluation of anatomic variation and surgical decision making. PMID: 32612471 [PubMed] (Source: Ochsner Journal)
Source: Ochsner Journal - July 4, 2020 Category: General Medicine Tags: Ochsner J Source Type: research

Neuroinvasive potential of a primary respiratory pathogen SARS- CoV2: Summarizing the evidences
Publication date: Available online 2 July 2020Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Durjoy Lahiri, Ritwick Mondal, Shramana Deb, Deebya Bandyopadhyay, Gourav Shome, Sukanya Sarkar, Subhas C. Biswas (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - July 4, 2020 Category: Endocrinology Source Type: research

A Long-term Survival Case of Pulmonary Tumor Thrombotic Microangiopathy due to Gastric Cancer Confirmed by the Early Diagnosis based on a Transbronchial Lung Biopsy.
Authors: Imakura T, Tezuka T, Inayama M, Miyamoto R, Abe A, Otsuka K, Yoshida S, Kudo E, Haku T Abstract Pulmonary tumor thrombotic microangiopathy (PTTM) is an acute, progressive, and fatal disease. PTTM manifests as subacute respiratory failure with pulmonary hypertension, progressive right-sided heart failure, and sudden death. An antemortem diagnosis of PTTM is very difficult to obtain, and many patients die within several weeks. We herein report a case of PTTM diagnosed based on a transbronchial lung biopsy. In this case, we finally diagnosed PTTM due to gastric cancer because of its histological identity. The...
Source: Internal Medicine - July 4, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research

Sequential serological surveys in the early stages of the coronavirus disease epidemic: limitations and perspectives
CONCLUSIONS: Serological screening may be an important tool for understanding the immunity of a population and planning community interventions. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - July 4, 2020 Category: Tropical Medicine Source Type: research

Diagnosis and treatment of isolated snoring —open questions and areas for future research
ConclusionSeveral major gaps in the literature on the diagnosis and treatment of isolated snoring were identified. For the majority of diagnostic and therapeutic measures for snoring, high-level scientific evidence is still lacking. (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 4, 2020 Category: Respiratory Medicine Source Type: research

The cost-effectiveness of as-needed budesonide/formoterol versus low-dose inhaled corticosteroid maintenance therapy in patients with mild asthma in the UK
As-needed budesonide/formoterol is effective in patients with mild asthma for whom low-dose inhaled corticosteroid (ICS) maintenance therapy is appropriate. We assessed the cost-effectiveness of this regimen versus maintenance low-dose ICS plus as-needed short-acting β2-agonist (SABA). (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 4, 2020 Category: Respiratory Medicine Authors: J. Mark FitzGerald, Sofie Arnetorp, Caitlin Smare, Danny Gibson, Karen Coulton, Kirsty Hounsell, Sarowar Golam, Mohsen Sadatsafavi Source Type: research

A Comparison of Mortality-related Risk Factors of COVID-19, SARS, and MERS: A Systematic Review and Meta-analysis
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel zoonotic pathogen. It is responsible for Coronavirus Disease 2019 (COVID-19) [1]. The COVID-19 pandemic has imposed a heavy burden on global health and medical systems [2]. A whole genome scan has shown that SARS-CoV-2 has a 79% similarity to Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), and a 50% similarity to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [3]. Currently, SARS-CoV-2 is classified as a SARS-associated coronavirus and taxonomically belongs to the subgenus of Sabek virus [3]. (Source: Journal of Infection)
Source: Journal of Infection - July 4, 2020 Category: Infectious Diseases Authors: Lvliang Lu, Wenyu Zhong, Ziwei Bian, Zhiming Li, Ke Zhang, Boxuan Liang, Yizhou Zhong, Manjiang Hu, Li Lin, Jun Liu, Xi Lin, Yuji Huang, Junying Jiang, Xingfen Yang, Xin Zhang, Zhenlie Huang Source Type: research

Initial emergency department mechanical ventilation strategies for COVID-19 hypoxemic respiratory failure and ARDS
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging viral pathogen that causes the novel coronavirus disease of 2019 (COVID-19) and may result in hypoxemic respiratory failure necessitating invasive mechanical ventilation in the most severe cases. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - July 4, 2020 Category: Emergency Medicine Authors: Skyler Lentz, Matthew A. Roginski, Tim Montrief, Mark Ramzy, Michael Gottlieb, Brit Long Source Type: research

A case report of possible novel coronavirus 2019 reinfection
Since December 2019, COVID-19, the clinical syndrome associated with SARS-CoV-2 infection, has infected more than 6.2 million people and brought the function of the global community to a halt. As the number of patients recovered from COVID-19 rises and the world transitions toward reopening, the question of acquired immunity versus the possibility of reinfection are critical to anticipating future viral spread. Here, we present a case of a patient previously recovered from COVID-19 who re-presents with new respiratory, radiographical, laboratory, and RT-PCR findings concerning for re-infection. (Source: The American Journa...
Source: The American Journal of Emergency Medicine - July 4, 2020 Category: Emergency Medicine Authors: Nicole M. Duggan, Stephanie M. Ludy, Bryant C. Shannon, Andrew T. Reisner, Susan R. Wilcox Source Type: research

EP News: Case Reports
As the number of patients inflicted with COVID-19 continue to increase, more is learned about the cardiovascular manifestations of the disease. The disease can result in severe systemic stress resulting in respiratory and hemodynamic failure. Takotsubo cardiomyopathy is reversible left ventricular apical ballooning typically mediated by severe stress in the absence of significant coronary artery stenosis. Khalid et al. (DOI: https://doi.org/10.1016/j.hrcr.2020.05.020) share a case of a 76-year-old female who was admitted to the intensive care unit (ICU) due to acute respiratory failure secondary to COVID-19 infection. (Source: Heart Rhythm)
Source: Heart Rhythm - July 4, 2020 Category: Cardiology Authors: T. Jared Bunch Source Type: research

Impact of the COVID-19 pandemic on cancer treatment: the patients ’ perspective
The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has inevitable consequences for medical care of non-COVID-19 patients. To assess the impact of this pandemic on oncological care, a nationwide survey was conducted among cancer patients in the Netherlands. (Source: European Journal of Cancer)
Source: European Journal of Cancer - July 4, 2020 Category: Cancer & Oncology Authors: K. de Joode, D.W. Dumoulin, V. Engelen, H.J. Bloemendal, M. Verheij, H.W.M. van Laarhoven, I.H. Dingemans, A.C. Dingemans, A.A.M. van der Veldt Tags: Original Research Source Type: research

High dose chemotherapy in a patient with COVID-19
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is an unprecedented challenge [1]. High dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT) represents a potentially curative option for testicular germ cell tumor (TGCT) [2], however, to our knowledge, to date there have been no reports on these regimens in patients with COVID-19. (Source: European Journal of Cancer)
Source: European Journal of Cancer - July 4, 2020 Category: Cancer & Oncology Authors: Ugo De Giorgi, Chiara Casadei, Giuseppe Bronte, Mattia Altini, Giovani Martinelli Tags: Letter to the Editor Source Type: research

Viruses, Vol. 12, Pages 723: Catching Common Cold Virus with a Net: Pyridostatin Forms Filaments in Tris Buffer That Trap Viruses —A Novel Antiviral Strategy?
Viruses, Vol. 12, Pages 723: Catching Common Cold Virus with a Net: Pyridostatin Forms Filaments in Tris Buffer That Trap Viruses—A Novel Antiviral Strategy? Viruses doi: 10.3390/v12070723 Authors: Antonio Real-Hohn Rong Zhu Haleh Ganjian Nahla Ibrahim Peter Hinterdorfer Heinrich Kowalski Dieter Blaas The neutrophil extracellular trap (ET) is a eukaryotic host defense machinery that operates by capturing and concentrating pathogens in a filamentous network manufactured by neutrophils and made of DNA, histones, and many other components. Respiratory virus-induced ETs are involved in tissue damage a...
Source: Viruses - July 4, 2020 Category: Virology Authors: Antonio Real-Hohn Rong Zhu Haleh Ganjian Nahla Ibrahim Peter Hinterdorfer Heinrich Kowalski Dieter Blaas Tags: Brief Report Source Type: research

IJERPH, Vol. 17, Pages 4814: Climate Change and Human Health: A Review of Allergies, Autoimmunity and the Microbiome
ing The impact of climate change on human health is a topic of critical importance. While only recently beginning to gain attention, it is clear that immediate action is necessary to minimize this impact. In our review, we will outline a subset of these effects in detail. We will examine how climate change has worsened respiratory allergic disease. We will discuss how climate change has altered antigen exposure, possibly disrupting antigen-specific tolerance by the immune system, leading, in turn, to an increase in the prevalence of immunologic diseases. Finally, we will explore how the loss of biodiversity related to ...
Source: International Journal of Environmental Research and Public Health - July 4, 2020 Category: Environmental Health Authors: Carly Ray Xue Ming Tags: Review Source Type: research

Anatomical distribution of respiratory tract leukocyte cell subsets in neonatal calves
Publication date: Available online 2 July 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Quinn K. Kolar, Lindsey A. Waddell, Anna Raper, Mara S. Rocchi, Darren J. Shaw, Alexander Corbishley, Jayne C. Hope (Source: Veterinary Immunology and Immunopathology)
Source: Veterinary Immunology and Immunopathology - July 3, 2020 Category: Veterinary Research Source Type: research

Recovery of a triazole-resistant Aspergillus fumigatus in respiratory specimen of COVID-19 patient in ICU – A case report
Publication date: Available online 2 July 2020Source: Medical Mycology Case ReportsAuthor(s): Théo Ghelfenstein Ferreira, Anastasia Saade, Alexandre Alanio, Stéphane Bretagne, Raffael Araujo de Castro, Samia Hamane, Elie Azoulay, Swann Bredin, Sarah Dellière (Source: Medical Mycology Case Reports)
Source: Medical Mycology Case Reports - July 3, 2020 Category: Biology Source Type: research

The Human Microbiome and Its Impacts on Health.
Authors: Ogunrinola GA, Oyewale JO, Oshamika OO, Olasehinde GI Abstract The human microbiome comprises bacteria, archaea, viruses, and eukaryotes which reside within and outside our bodies. These organisms impact human physiology, both in health and in disease, contributing to the enhancement or impairment of metabolic and immune functions. Micro-organisms colonise various sites on and in the human body, where they adapt to specific features of each niche. Facultative anaerobes are more dominant in the gastrointestinal tract, whereas strict aerobes inhabit the respiratory tract, nasal cavity, and skin surface. The ...
Source: International Journal of Microbiology - July 3, 2020 Category: Microbiology Tags: Int J Microbiol Source Type: research

Respiratory Distress Syndrome in Neonates Delivered at Term-gestation by Elective Cesarean Section at Tertiary Care Hospital in Oman.
Conclusions: The prevalence of RDS was low. Giving antenatal corticosteroids for patients with planned elective cesarean at term did not seem to have a beneficial effect on neonatal respiratory morbidity. Further studies with larger sample size including multiple centers is recommended. PMID: 32607253 [PubMed] (Source: Oman Medical Journal)
Source: Oman Medical Journal - July 3, 2020 Category: Middle East Health Tags: Oman Med J Source Type: research

Inhaler recycling scheme that cut carbon emissions equivalent to more than 8,500 cars is scrapped
A scheme to recycle respiratory inhalers, which has  cut carbon dioxide emissions equivalent to taking around 8,600 cars off UK roads, is ending. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - July 3, 2020 Category: Drugs & Pharmacology Source Type: research

Effects of acute inspiratory loading during treadmill running on cerebral, locomotor and respiratory muscle oxygenation in women soccer players
Publication date: Available online 2 July 2020Source: Respiratory Physiology & NeurobiologyAuthor(s): Flavia Rossi Caruso, Bruno Archiza, Daniela Kuguimoto Andaku, Renata Trimer, José Carlos Bonjorno-Junior, Claudio Ricardo de Oliveira, Cleiton A. Libardi, Shane A. Phillips, Ross Arena, Renata Gonçalves Mendes, Audrey Borghi-Silva (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - July 3, 2020 Category: Respiratory Medicine Source Type: research

Non-invasive CPAP in mild and moderate ARDS secondary to SARS-CoV-2
Publication date: Available online 3 July 2020Source: Respiratory Physiology & NeurobiologyAuthor(s): A. Pagano, G. Porta, G. Bosso, E. Allegorico, C. Serra, F. Dello Vicario, V. Minerva, T. Russo, C. Altruda, P. Arbo, F.G. Numis (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - July 3, 2020 Category: Respiratory Medicine Source Type: research

Effects of alkaline agents on respiratory characteristics in rabbit models of respiratory failure
Publication date: Available online 3 July 2020Source: Respiratory Physiology & NeurobiologyAuthor(s): Tomonori Yamashita, Akinori Uchiyama, Yukiko Koyama, Takeshi Yoshida, Aiko Tanaka, Yuji Fujino (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - July 3, 2020 Category: Respiratory Medicine Source Type: research

Massive hemoptysis: A rare case with uncommon presentation and rapid response – A case report
Publication date: Available online 2 July 2020Source: Respiratory Medicine Case ReportsAuthor(s): Vishak Acharya, A. shreenivasa, Deepa Adiga, Chakrapani Mahabala, Sajjan Shenoy, Santosh Rai (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - July 3, 2020 Category: Respiratory Medicine Source Type: research

Acute eosinophilic pneumonia following inhalation of turpentine oil: a case report
Publication date: Available online 2 July 2020Source: Respiratory Medicine Case ReportsAuthor(s): Yasuhiro Umekage, Shunsuke Okumura, Toshiyuki Tenma, Yoshihiro Kazebayashi, Noriko Hirai, Yoshinori Minami, Kazushi Doshita, Takaaki Sasaki, Yasushi Yamamoto, Yoshinobu Ohsaki (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - July 3, 2020 Category: Respiratory Medicine Source Type: research

Lophomonas sp. in the upper and lower respiratory tract of patients from a hospital in Lambayeque, Peru: clinical case studies
Publication date: Available online 2 July 2020Source: Respiratory Medicine Case ReportsAuthor(s): Virgilio E. Failoc-Rojas, Sebastian Iglesias-Osores, Heber Silva-Díaz (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - July 3, 2020 Category: Respiratory Medicine Source Type: research

Present Situation and Future Progress of Inhaled Lung Cancer Therapy: Necessity of Inhaled Formulations with Drug Delivery Functions.
Abstract Inhaled lung cancer therapy is promising because of direct and noninvasive drug delivery to the lungs with low potential for severe systemic toxicity. Thus chemotherapeutic drugs have been administered clinically by nebulization of solution or suspension formulations, which demonstrated their limited pulmonary absorption and relatively mild systemic toxicity. In all these clinical trials, however, there was no obviously superior anticancer efficacy in lung cancer patients even at the maximum doses of drugs limited by pulmonary toxicity. Therefore methods that deliver both higher anticancer efficacy and lo...
Source: Chemical and Pharmaceutical Bulletin - July 3, 2020 Category: Drugs & Pharmacology Authors: Okuda T, Okamoto H Tags: Chem Pharm Bull (Tokyo) Source Type: research

The Effect of Aerosolized Chlorpheniramine Maleate on Exercise Induced Bronchospasm and Gas Exchange in Asthmatics.
This study was conducted to evaluate the effect of Chlorpheniramine Maleate aerosol inhalation on flow volumes and gas exchange. Materials and Methods: 25 established patients of stabilized bronchial asthma (18 to 44 years) with history of EIA attending Allergy OPD, Medical OPD or Chest clinic were included in the present study. Patients were studied for 3 days in a week at the same time of day. Baseline spirometry was done to know test parameters, i.e. FEV1, PEFR and FEF50%. Gas exchange study during rest including minute ventilation (VE), oxygen consumption (VO2), Carbon dioxide produced per minute (VCO2), Respirator...
Source: Journal of the Association of Physicians of India - July 3, 2020 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Comparative Analysis of Clinical and Biochemical Profile of Exertional Heat Related Illness Among Cadets in a Military Training Centre in South India: A Single Centre Experience.
Conclusion: Tachycardia, transaminitis and hyponatremia was widely observed in patients with heat related illness and these changes occur at higher rates in patients in heat stroke as compared to heat exhaustion. PMID: 32610843 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - July 3, 2020 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Infections in Systemic Lupus Erythematosus.
Conclusion: SLE patients are predisposed to various minor as well as lifethreatening infections. It is essential to prevent infections by screening, reducing exposure to sources or contacts of infection and minimizing the exposure to immunosuppressive agents while controlling disease activity. PMID: 32610860 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - July 3, 2020 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

[Pituitary tumor resection in a patient with SARS-CoV-2 (COVID-19) infection. A case report and suggested airway management guidelines].
Authors: Santos CDSE, Filho LMDCL, Santos CAT, Neill JS, Vale HF, Kurnutala LN Abstract The 2020 pandemic caused by the novel coronavirus, COVID-19, had its headquarters in China. It causes Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and presents a broad spectrum of clinical manifestations, ranging from entirely asymptomatic through severe acute respiratory failure and death. Presuming a significant quantity of ventilator-dependent patients, several institutions strategically delayed elective surgeries. Particularly procedures performed involving the nasal mucosa, such as a transsphenoidal approach...
Source: Revista Brasileira de Anestesiologia - July 3, 2020 Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research

Severe Acute Respiratory Syndrome Coronavirus 2 Prevalence, Seroprevalence, and Exposure Among Evacuees from Wuhan, China, 2020
B. D. Hallowell et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - July 3, 2020 Category: Infectious Diseases Source Type: research

Computational modeling of fiber transport in human respiratory airways —A review
AbstractInvestigations on the respiratory transport and deposition of airborne asbestos, man-made vitreous fibers (MMVFs), and carbon nanofiber/carbon nanotubes have been actively conducted in the past few decades. The elongated particles ’ distinctive needle-like geometry has been identified as the main cause of extreme carcinogenicity when compared to inhaled spherical particles. Consequently, uncovering the intrinsic relationship between the particle’s unique elongated shape and its transport characteristics in human respirato ry systems is crucial for understanding fiber inhalation toxicity. Currently, such...
Source: European Journal of Applied Physiology - July 3, 2020 Category: Physiology Source Type: research

SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride
Conclusions: Our data suggest the pivotal role of impaired mitochondrial biogenesis in developmental fluoride neurotoxicity and the underlying SIRT1 signaling dysfunction in such neurotoxic process, which emphasizes RSV as a potential therapeutic dietary agent for relieving developmental fluoride neurotoxicity. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Qian Zhao, Zhiyuan Tian, Guoyu Zhou, Qiang Niu, Jingwen Chen, Pei Li, Lixin Dong, Tao Xia, Shun Zhang, Aiguo Wang Tags: Research Paper Source Type: research

CT quantification of pneumonia lesions in early days predicts progression to severe illness in a cohort of COVID-19 patients
Conclusions: CT quantification of pneumonia lesions can early and non-invasively predict the progression to severe illness, providing a promising prognostic indicator for clinical management of COVID-19. (Source: Theranostics)
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Fengjun Liu, Qi Zhang, Chao Huang, Chunzi Shi, Lin Wang, Nannan Shi, Cong Fang, Fei Shan, Xue Mei, Jing Shi, Fengxiang Song, Zhongcheng Yang, Zezhen Ding, Xiaoming Su, Hongzhou Lu, Tongyu Zhu, Zhiyong Zhang, Lei Shi, Yuxin Shi Tags: Research Paper Source Type: research

Multicenter cohort study demonstrates more consolidation in upper lungs on initial CT increases the risk of adverse clinical outcome in COVID-19 patients
In this study, we aimed to assess the imaging characteristics and risk factors associated with adverse composite endpoints in patients with COVID-19 pneumonia.Methods: This retrospective cohort study enrolled patients with laboratory-confirmed COVID-19 from 24 designated hospitals in Jiangsu province, China, between 10 January and 18 February 2020. Clinical and initial CT findings at admission were extracted from medical records. Patients aged
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Qian Yu, Yuancheng Wang, Shan Huang, Songqiao Liu, Zhen Zhou, Shijun Zhang, Zhen Zhao, Yizhou Yu, Yi Yang, Shenghong Ju Tags: Research Paper Source Type: research

Adaptive changes induced by noble-metal nanostructures in vitro and in vivo
The unique features of noble-metal nanostructures (NMNs) are leading to unprecedented expansion of research and exploration of their application in therapeutics, diagnostics and bioimaging fields. With the ever-growing applications of NMNs, both therapeutic and environmental NMNs are likely to be exposed to tissues and organs, requiring careful studies towards their biological effects in vitro and in vivo. Upon NMNs exposure, tissues and cells may undergo a series of adaptive changes both in morphology and function. At the cellular level, the accumulation of NMNs in various subcellular organelles including lysosomes, endop...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Qianqian Huang, Jinchao Zhang, Yuanyuan Zhang, Peter Timashev, Xiaowei Ma, Xing-Jie Liang Tags: Review Source Type: research

Optimizing use of theranostic nanoparticles as a life-saving strategy for treating COVID-19 patients
On the 30th of January 2020, the World Health Organization fired up the sirens against a fast spreading infectious disease caused by a newly discovered Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and gave this disease the name COVID-19. While there is currently no specific treatment for COVID-19, several off label drugs approved for other indications are being investigated in clinical trials across the globe.In the last decade, theranostic nanoparticles were reported as promising tool for efficiently and selectively deliver therapeutic moieties (i.e. drugs, vaccines, siRNA, peptide) to target sites of infe...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Rasha Itani, Mansour Tobaiqy, Achraf Al Faraj Tags: Review Source Type: research

Primer design for quantitative real-time PCR for the emerging Coronavirus SARS-CoV-2
In December 2019, a new coronavirus disease (COVID-19) outbreak occurred in Wuhan, China. Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), which is the seventh coronavirus known to infect humans, is highly contagious and has rapidly expanded worldwide since its discovery. Quantitative nucleic acid testing has become the gold standard for diagnosis and guiding clinical decisions regarding the use of antiviral therapy. However, the RT-qPCR assays targeting SARS-CoV-2 have a number of challenges, especially in terms of primer design. Primers are the pivotal components of a RT-qPCR assay. Once virus mutation and r...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Dandan Li, Jiawei Zhang, Jinming Li Tags: Review Source Type: research

COVID-19: Progress in diagnostics, therapy and vaccination
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has recently become a pandemic. As the sudden emergence and rapid spread of SARS-CoV-2 is endangering global health and the economy, the development of strategies to contain the virus's spread are urgently needed. At present, various diagnostic kits to test for SARS-CoV-2 are available for use to initiate appropriate treatment faster and to limit further spread of the virus. Several drugs have demonstrated in vitro activity against SARS-CoV-2 or potential clinical benefits. In addition, institutions and companies worl...
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Xue Liu, Chao Liu, Gang Liu, Wenxin Luo, Ningshao Xia Tags: Review Source Type: research

Low-Density Lipoprotein Apheresis in Patients with Acute Kidney Injury Due to Minimal Change Disease Requiring Acute Renal Replacement Therapy.
Authors: Terada K, Mugishima K, Kawasaki S, Itagaki F, Yamada T, Sakai Y Abstract Low-density lipoprotein apheresis (LDL-A) has been developed as a therapy for familial hypercholesterolemia, but LDL-A has also been used as a general treatment for drug-resistant nephrotic syndrome (NS) due to focal segmental glomerulosclerosis (FSGS). The patients with NS due to minimal change disease (MCD) are often difficult to control effective circulating plasma volume, causes acute kidney injury (AKI), and when diuretics are not effective and the respiratory condition of patients worsens, patients require acute renal replacemen...
Source: International Journal of Nephrology and Renovascular Disease - July 3, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Ambient particulate matter and biomass burning: an ecological time series study of respiratory and cardiovascular hospital visits in northern Thailand
Exposure to particulate matter (PM) emitted from biomass burning is an increasing concern, particularly in Southeast Asia. It is not yet clear how the source of PM influences the risk of an adverse health outc... (Source: Environmental Health)
Source: Environmental Health - July 3, 2020 Category: Environmental Health Authors: W. Mueller, M. Loh, S. Vardoulakis, H. J. Johnston, S. Steinle, N. Precha, W. Kliengchuay, K. Tantrakarnapa and J. W. Cherrie Tags: Research Source Type: research