[The role of videolaryngoscope in endotracheal intubation training programs].
CONCLUSIONS: The success rate of endotracheal intubation decreases in paramedic students who used VL during endotracheal intubation education and had to use Macintosh laryngoscopes later. Therefore we believe that solely videolaryngoscopes is not enough in endotracheal intubation training programs. PMID: 30025947 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Anestesiologia)
Source: Revista Brasileira de Anestesiologia - July 23, 2018 Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research

[Relationship between cigarette smoking and the carbon monoxide concentration in the exhaled breath with perioperative respiratory complications].
CONCLUSIONS: Cigarette smoking was shown to increase the incidence of intraoperative respiratory complications while under general anesthesia. Moreover, the estimated preoperative carbon monoxide level in the exhaled breath level may serve as an indicator of the potential risk of perioperative respiratory complications. PMID: 30025946 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Anestesiologia)
Source: Revista Brasileira de Anestesiologia - July 23, 2018 Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research

Effects of Iodixanol on Respiratory Functions during Coronary Angiography and the Role of Body Composition.
Abstract Purpose: The purposes of this study are to assess the acute effects of iodixanol, an iso-osmolar contrast media, on pulmonary functions and to evaluate the body composition in order to find out its role in causing this deterioration. Methods: 35 male and 25 female patients undergoing diagnostic coronary angiography (CA) were enrolled in the study. Before CA, all patients' body compositions were evaluated by measuring their body mass indexes (BMIs) and waist-to-hip ratios (WHRs). Total body waters (TBWs), fat masses (FMs), fat-free masses (FFMs), and basal metabolism rates (BMRs) were measured via bio...
Source: Cardiology Research and Practice - July 23, 2018 Category: Cardiology Authors: Guzel D, Vural MG, Akdemir R Tags: Cardiol Res Pract Source Type: research

Detection of Rifampicin- and Isoniazid-Resistant Mycobacterium tuberculosis Using the Quantamatrix Multiplexed Assay Platform System.
CONCLUSIONS: The QMAP system may serve as a useful screening method for identifying and accurately discriminating MTBC from non-tuberculous mycobacteria, as well as determining RIF- and INH-resistant MTB strains. PMID: 30027701 [PubMed - in process] (Source: Annals of Laboratory Medicine)
Source: Annals of Laboratory Medicine - July 22, 2018 Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research

Assessing effects of inhaled antibiotics in adults with non-cystic fibrosis bronchiectasis - experiences from recent clinical trials.
The objective of this review is to provide an overview of NCFB and critically evaluate the evidence supporting the outcome measures used in recent clinical trials of inhaled antibiotics. These include quantitative changes in bacterial load, sputum purulence and yield, inflammatory markers, and lung function, as well as clinical changes in exacerbations, exacerbation frequency, hospitalizations, and health-related quality of life. Expert commentary: Recently completed large trials of inhaled antibiotics in NCFB did not consistently meet pre-specified endpoints, suggesting that we have not yet found the best enrollment crite...
Source: Expert Review of Respiratory Medicine - July 22, 2018 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Esophageal resection for cancer in The University of Hong Kong, Queen Mary Hospital, Hong Kong, China (1982-2008).
Authors: Wong J Abstract Esophageal resection is a high-risk procedure. In the early 1980s, it carried a mortality of more than 20%. Through a concerted effort which include meticulous surgical technique, vigilant post-operative care, and a low threshold to correct respiratory problem, the mortality rate was reduced to almost 0%. Our single layer continuous anastomotic technique also dramatically reduced the anastomotic leakage rate. PMID: 30026969 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - July 22, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Original "double-step" technique for large superior sulcus tumors invading the anterior chest wall without subclavian vessels involvement.
Conclusions: The technique has several advantages: trauma related to double access is negligible; radical resection is facilitated, anterior chest wall resection is accomplished without sternal or clavicular injury, en-bloc chest wall and lung resection is made straightforward despite the extended area of resected ribs attached to the tumor, released within the chest cavity; chest wall stabilization is simple and reliable. The only disadvantage is that the patient's surgical position needs to be changed. PMID: 30026971 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - July 22, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Chest wall resection and reconstruction for tumors: analysis of oncological and functional outcome.
Conclusions: free surgical margins are the main oncological prognostic factor in these patients. In patients who underwent resection of two or more ribs in a critical area, reconstruction of the bony thorax can significantly reduce the post-operative respiratory complication rate. PMID: 30026972 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - July 22, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Secondary EMR data for quality improvement and research: A comparison of manual and electronic data collection from an integrated critical care electronic medical record system
ConclusionsManual validation processes of electronic data are complex in comparison to validation of traditional clinical documentation. This study represents a straightforward approach to substantiate the use of system repositories as a reliable and efficient approach to collect high quality secondary use data. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 22, 2018 Category: Gastroenterology Source Type: research

Non-alcoholic fatty liver disease is an independent risk factor for inflammation in obstructive sleep apnea syndrome in obese Asian Indians
ConclusionNAFLD is an additional risk factor in OSA subject which contributes to systemic inflammation in Asian Indians. (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 22, 2018 Category: Respiratory Medicine Source Type: research

Herd level estimation of probability of disease freedom applied on the Norwegian control program for bovine respiratory syncytial virus and bovine coronavirus
Publication date: Available online 21 July 2018Source: Preventive Veterinary MedicineAuthor(s): Ingrid Toftaker, Estelle Ågren, Maria Stokstad, Ane Nødtvedt, Jenny FrösslingAbstractA national control program against bovine respiratory syncytial virus (BRSV) and bovine coronavirus (BCV) was launched in Norway in 2016. A key strategy in the program is to test for presence of antibodies and protect test-negative herds from infection. Because these viruses are endemic, the rate of re-introduction can be high, and a disease-free status will become more uncertain as time from testing elapses. The aim of this st...
Source: Preventive Veterinary Medicine - July 21, 2018 Category: Veterinary Research Source Type: research

Correlation of surface respiratory electromyography with esophageal diaphragm electromyography
Publication date: Available online 21 July 2018Source: Respiratory Physiology & NeurobiologyAuthor(s): Lin Lin, Lili Guan, Weiliang Wu, Rongchang ChenAbstractObjectivesTo assess the correlation between surface respiratory electromyography(sEMG) and esophageal diaphragm electromyography(EMGdi) at different levels of neural respiratory drive (NRD).DesignRandomised parallel design controlled trial.SettingThe First Affiliated Hospital of Guangzhou Medical University.Participants15 healthy subjects and 1 severe to very severe stable COPD patients were studied.Interventions15 healthy subjects performed incremental inspirator...
Source: Respiratory Physiology and Neurobiology - July 21, 2018 Category: Respiratory Medicine Source Type: research

Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats
In conclusion, elderly rats submitted to an experimental model of tibial fracture displayed memory impairment accompanied by an increase in oxidative stress, mitochondrial dysfunction and reduced neurotrophin level. (Source: Brain, Behavior, and Immunity)
Source: Brain, Behavior, and Immunity - July 21, 2018 Category: Neurology Source Type: research

Respiratory signs, fever and lymphopenia in calves inoculated with Brazilian HoBi-like pestiviruses
Publication date: Available online 21 July 2018Source: Microbial PathogenesisAuthor(s): J.C. Jardim, B.P. Amaral, M. Martins, P. Sebastian, M.B. Heinemann, A. Cortez, R. Weiblen, E.F. FloresAbstractHobi-like viruses (HobiPeV) comprise a novel, recently classified species of bovine pestiviruses, originally identified in commercial fetal bovine serum of Brazilian origin and, subsequently, isolated from diseased animals in several countries. Although frequently isolated from clinical cases, most HobiPeV isolates failed to reproduce overt disease in cattle upon experimental inoculation. Herein, we describe the outcome of exper...
Source: Microbial Pathogenesis - July 21, 2018 Category: Infectious Diseases Source Type: research

Clofazimine: A useful antibiotic for drug-resistant tuberculosis.
Abstract Drug resistance is still the major threat to global tuberculosis (TB) control, and drug-resistant (DR) Mycobacterium tuberculosis (M. tuberculosis) strains have become the main challenge worldwide. Currently used antibiotics for treatment of DR-TB are often poorly tolerated and not sufficiently effective. Since the therapeutic options are still limited, the main strategy for treatment of DR-TB is to repurpose existing anti-mycobacterial agents. Clofazimine (CFZ) is one such drug that has recently attracted interest against DR-TB. CFZ is a hydrophobic riminophenazine that was initially synthesized as an an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 21, 2018 Category: Drugs & Pharmacology Authors: Mirnejad R, Asadi A, Khoshnood S, Mirzaei H, Heidary M, Fattorini L, Ghodousi A, Darban-Sarokhalil D Tags: Biomed Pharmacother Source Type: research

Thyme extract increases mucociliary-beating frequency in primary cell lines from chronic obstructive pulmonary disease patients.
Abstract Chronic obstructive pulmonary disease (COPD) is a respiratory disorder characterized by a progressive and irreversible airflow limitation. COPD is associated to a chronic inflammatory response with infiltration of inflammatory cells in the surface epithelium of large airways and abnormalities in structure and functions of cilia. Thyme (Thymus vulgaris L.) is a traditional medicinal plant of the Mediterranean area used to treat respiratory disorders. We previously evidenced that thyme extract reduce IL-1beta and IL-8, by downregulating the activated NF-κB levels, suggesting its potential therapeutica...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 21, 2018 Category: Drugs & Pharmacology Authors: Nabissi M, Marinelli O, Morelli MB, Nicotra G, Iannarelli R, Amantini C, Santoni G, Maggi F Tags: Biomed Pharmacother Source Type: research

Evaluation of simulation debriefing methods with interprofessional learning.
Authors: Brown DK, Wong AH, Ahmed RA Abstract Interprofessional education (IPE) using simulations provides a rich environment for mastery learning and deliberate practice. The debriefing phase is identified as the most valuable by learners, yet investigation into the most effective format for debriefing interprofessional (IP) groups has largely gone unexplored. To determine the best practices in IP simulation debriefing, we compared perceived effectiveness of in-person versus teledebriefing, and single versus IP co-debriefer models according to 404 Debriefing Assessment for Simulation in Healthcare Student-Version ...
Source: Journal of Interprofessional Care - July 21, 2018 Category: Health Management Tags: J Interprof Care Source Type: research

Pregabalin and dexmedetomidine conscious sedation for flexible bronchoscopy: a randomized double blind controlled study.
Authors: Ibrahim E, Sultan W, Helal S, Abo-Elwafa H, Abdelaziz A Abstract BACKGROUND: Conscious sedation is usually required during flexible bronchoscopy. Sedation should be achieved without respiratory depression or loss of consciousness. The present study was designed to evaluate the effect of pregabalin pre-medication on reducing the amount of sedatives and to show its advantages for patients undergoing flexible bronchoscopy with dexmedetomidine. METHODS: Seventy patients undergoing elective flexible bronchoscopy were randomly divided into two groups of 35 patients each. All patients received premedication o...
Source: Minerva Anestesiologica - July 21, 2018 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Aggressive versus symptom-guided drainage of malignant pleural effusion via indwelling pleural catheters (AMPLE-2): an open-label randomised trial
Publication date: Available online 20 July 2018Source: The Lancet Respiratory MedicineAuthor(s): Sanjeevan Muruganandan, Maree Azzopardi, Deirdre B Fitzgerald, Ranjan Shrestha, Benjamin C H Kwan, David C L Lam, Christian C De Chaneet, Muhammad Redzwan S Rashid Ali, Elaine Yap, Claire L Tobin, Luke A Garske, Phan T Nguyen, Christopher Stanley, Natalia D Popowicz, Christopher Kosky, Rajesh Thomas, Catherine A Read, Charley A Budgeon, David Feller-Kopman, Nick A MaskellSummaryBackgroundIndwelling pleural catheters are an established management option for malignant pleural effusion and have advantages over talc slurry pleurode...
Source: The Lancet Respiratory Medicine - July 21, 2018 Category: Respiratory Medicine Source Type: research

Six-lobe bronchoalveolar lavage in children with cystic fibrosis
Publication date: Available online 20 July 2018Source: The Lancet Respiratory MedicineAuthor(s): Barry Linnane, Paul McNally (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 21, 2018 Category: Respiratory Medicine Source Type: research

Six-lobe bronchoalveolar lavage in children with cystic fibrosis – Authors' reply
Publication date: Available online 20 July 2018Source: The Lancet Respiratory MedicineAuthor(s): Julian T Forton, Iolo Doull, Lena P Thia, CF-SpIT authors (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 21, 2018 Category: Respiratory Medicine Source Type: research

ECMO in severe acute respiratory distress syndrome: a light at the end of the tunnel?
Publication date: Available online 20 July 2018Source: The Lancet Respiratory MedicineAuthor(s): Matthias Derwall, Rolf Rossaint (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 21, 2018 Category: Respiratory Medicine Source Type: research

Quantifying outcomes for palliative pleural interventions
Publication date: Available online 20 July 2018Source: The Lancet Respiratory MedicineAuthor(s): David E Ost (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 21, 2018 Category: Respiratory Medicine Source Type: research

Study of the usefulness of small-bore aspiration catheters (Aspiration Kit®) for treating pneumothorax
The objective of this study was to examine the usefulness of these less invasive small-bore aspiration catheters for drainage of pneumothorax.MethodsBaseline characteristics and laboratory test data at admission of 70 patients who were admitted to and underwent drainage treatment for pneumothorax at our hospital between April 2011 and February 2017 were retrospectively reviewed based on their medical records. The primary endpoints were factors associated with drainage treatment failure, and baseline characteristics and laboratory test data were compared between those treated with a small-bore aspiration catheter and those ...
Source: Respiratory Investigation - July 21, 2018 Category: Respiratory Medicine Source Type: research

Objective assessment of obstructive sleep apnea in normal pregnant and preeclamptic women.
Authors: Keshavarzi F, Mehdizadeh S, Khazaie H, Ghadami MR Abstract OBJECTIVE: Obstructive sleep apnea (OSA) is a risk factor for adverse pregnancy outcomes. The aim of this study was to evaluate the association between OSA and preeclampsia. METHODS: Between 30 and 39 weeks gestation, objective sleep apnea were evaluated in 38 normal pregnant and 40 preeclamptic women. Preeclampsia was defined by having a blood pressure (BP)> 140/90 mmHg on two occasions after the 20th week of pregnancy with excess protein in the urine (> 300 mg in 24 h) or 30 mg persistent proteinuria (...
Source: Hypertension in Pregnancy - July 21, 2018 Category: OBGYN Tags: Hypertens Pregnancy Source Type: research

Evaluation of ceftazidime-avibactam for serious infections due to multidrug and extensive drug resistant pseudomonas aeruginosa
ConclusionsCeftazidime-avibactam may be a valuable option for serious infections due to resistant P. aeruginosa. (Source: Journal of Global Antimicrobial Resistance)
Source: Journal of Global Antimicrobial Resistance - July 21, 2018 Category: Infectious Diseases Source Type: research

The use of a smart-textile garment during high-intensity functional training. A Pilot Study.
CONCLUSIONS: The Hx smart garment may be utilized to provide select cardiorespiratory data in a TM and HIFT session. We recommend that the validity and reliability be fully established before the Hx smart garment is entirely utilized for all cardiorespiratory data and research purposes in a field-based environment. PMID: 30024125 [PubMed - as supplied by publisher] (Source: Journal of Sports Medicine and Physical Fitness)
Source: Journal of Sports Medicine and Physical Fitness - July 21, 2018 Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research

In acute respiratory distress syndrome, is extracorporeal membrane oxygenation an adjuvant for "everyone"?
In acute respiratory distress syndrome, is extracorporeal membrane oxygenation an adjuvant for "everyone"? J Thorac Dis. 2018 Jun;10(Suppl 17):S2035-S2039 Authors: Broman LM PMID: 30023112 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - July 21, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The PRESET-Score: the extrapulmonary predictive survival model for extracorporeal membrane oxygenation in severe acute respiratory distress syndrome.
Authors: Montero S, S.sky AS, Schmidt M PMID: 30023113 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - July 21, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

What about prognostic outcome parameters in patients with acute respiratory distress syndrome (ARDS) treated with veno-venous extracorporeal membrane oxygenation (VV-ECMO)?
Authors: Datzmann T, Träger K PMID: 30023118 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - July 21, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Prone positioning acute respiratory distress syndrome patients.
Authors: Guérin C PMID: 30023128 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - July 21, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Sensory dysfunction and traumatic brain injury severity among deployed post-9/11 veterans: a chronic effects of neurotrauma consortium study.
CONCLUSIONS: Sensory problems affect a substantial number of deployed Post-9/11 Veterans and are more common among those with TBI or with exposure to deployment-related blast exposure. Because sensory problems profoundly impact quality of life, their identification and enhanced education and therapy are vital tools to improve prognosis for these relatively young Veterans. PMID: 30024786 [PubMed - as supplied by publisher] (Source: Brain Injury)
Source: Brain Injury - July 21, 2018 Category: Neurology Tags: Brain Inj Source Type: research

[usefulness of the forced oscillation technique in the diagnosis of cough variant asthma with prolonged or chronic cough].
[USEFULNESS OF THE FORCED OSCILLATION TECHNIQUE IN THE DIAGNOSIS OF COUGH VARIANT ASTHMA WITH PROLONGED OR CHRONIC COUGH]. Arerugi. 2018;67(6):759-766 Authors: Kato K, Tanaka H Abstract BACKGROUND: Usefulness of carrying out the reversibility test after inhaling bronchodilator by forced oscillation technique (FOT) in addition to spirometry was investigated in the diagnosis of bronchial asthma (BA), cough variant asthma (CVA) and allergic rhinitis (AR) with prolonged or chronic cough. METHODS: The subjects were the 622 patients at Idaimaeminamiyojo Clinic in Sapporo who complained cough over three...
Source: Arerugi - July 21, 2018 Category: Allergy & Immunology Authors: Kato K, Tanaka H Tags: Arerugi Source Type: research

Pediatric trauma-associated acute respiratory distress syndrome: Incidence, risk factors, and outcomes
The objective of this study was to determine risk factors and outcomes specifically related to pediatric trauma-associated ARDS (PT-ARDS). (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - July 21, 2018 Category: Surgery Authors: Amory de Roulet, Rita V. Burke, Joanna Lim, Stephanie Papillon, David W. Bliss, Henri R. Ford, Jeffrey S. Upperman, Kenji Inaba, Aaron R. Jensen Tags: Original Investigation Source Type: research

Smartphone-based delivery of oropharyngeal exercises for treatment of snoring: a randomized controlled trial
ConclusionsSmartphone application-administered upper airway training reduces objective and subjective snoring measures and improves sleep quality.Trial registrationClinicalTrials.gov; no.: NCT03264963; URL:www.clinicaltrials.gov (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 21, 2018 Category: Respiratory Medicine Source Type: research

Peripheral endothelial function is positively associated with maximal aerobic capacity in patients with chronic obstructive pulmonary disease
Patients with COPD are frequently diagnosed with cardiovascular disease. Peripheral endothelial dysfunction is an underlying mechanism and can be used as an early marker of cardiovascular impairment. To date, little is known on the association between peripheral endothelial dysfunction, cardiovascular risk factors and measurements of exercise capacity in patients with COPD. Therefore, we aimed to determine the relation between endothelial function and patient characteristics, cardiovascular risk factors and (micro)vascular and functional performance in patient with CODP. (Source: Respiratory Medicine)
Source: Respiratory Medicine - July 21, 2018 Category: Respiratory Medicine Authors: Anouk W. Vaes, Martijn A. Spruit, Jan Theunis, Emiel F.M. Wouters, Patrick De Boever Source Type: research

Prevalence and seasonality of common viral respiratory pathogens, including Cytomegalovirus in children, between 0 –5 years of age in KwaZulu-Natal, an HIV endemic province in South Africa
Acute respiratory tract infections contribute significantly to morbidity and mortality among young children in resource-poor countries. However, studies on the viral aetiology of acute respiratory infections, ... (Source: BMC Pediatrics)
Source: BMC Pediatrics - July 21, 2018 Category: Pediatrics Authors: Temitayo Famoroti, Wilbert Sibanda and Thumbi Ndung ’u Tags: Research article Source Type: research

A case of acute respiratory distress syndrome with sixth cranial nerve palsy
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - July 21, 2018 Category: Intensive Care Source Type: research

Demand, End-Uses, and Conservation of Alpine Medicinal Plant Neopicrorhiza scrophulariiflora (Pennell) D. Y. Hong in Central Himalaya.
Authors: Kafle G, Bhattarai Sharma I, Siwakoti M, Shrestha AK Abstract Neopicrorhiza scrophulariiflora (Pennell) D. Y. Hong of Scrophulariaceae family (hereinafter referred to as Neopicrorhiza) has medicinally important rhizomes with high levels of trade. What factors drive demand for Neopicrorhiza in Central Himalaya is unknown. In this context, a nationwide comprehensive survey was conducted from September 2016 to March 2017 to assess demand, end-uses, and conservation of dry Neopicrorhiza rhizomes in Nepal. A total of 2313 herbal products were surveyed for Neopicrorhiza as an ingredient in 38 retailer shops. Pro...
Source: Evidence-based Complementary and Alternative Medicine - July 20, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

COMPARATIVE TOXICITY OF COREXIT® 9500, OIL, AND A COREXIT®/OIL MIXTURE ON THE EASTERN OYSTER, CRASSOSTREA VIRGINICA (Gmelin)
Publication date: Available online 20 July 2018Source: Aquatic ToxicologyAuthor(s): Lindsay Jasperse, Milton Levin, Katherine Tsantiris, Roxanna Smolowitz, Christopher Perkins, J. Evan Ward, Sylvain De GuiseAbstractGiven their particle feeding behavior, sessile behavior, and abundance in coastal zones, bivalves are at significant risk for exposure to oil and oil dispersant following environmental disasters like the Deepwater Horizon oil spill. However, the effects of oil combined with oil dispersants on the health of oysters are not well studied. Therefore, eastern oysters (Crassostrea virginica) were exposed in vivo to Co...
Source: Aquatic Toxicology - July 20, 2018 Category: Toxicology Source Type: research

Annual Report on Healthcare for Children and Youth in the United States: Focus on 30-day unplanned inpatient readmissions, 2009-2014
CONCLUSIONS/IMPLICATIONSThis study provides a baseline assessment for examining trends in 30-day unplanned pediatric readmissions, an important quality metric as the provisions of the Children's Health Insurance Program Reauthorization Act and the Affordable Care Act are changed and implemented in the future. Over 50,000 pediatric hospital stays in 2014 occurred within 30 days of a previous hospitalization, with an average cost of $13,800. This report is timely, as the health care system works to become more patient-centered and public and private payers grapple with how to pay for quality care for children. The report pro...
Source: Academic Pediatrics - July 20, 2018 Category: Pediatrics Source Type: research

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study
Publication date: Available online 20 July 2018Source: The Lancet HaematologyAuthor(s): Carolyne M Ndila, Sophie Uyoga, Alexander W Macharia, Gideon Nyutu, Norbert Peshu, John Ojal, Mohammed Shebe, Kennedy O Awuondo, Neema Mturi, Benjamin Tsofa, Nuno Sepúlveda, Taane G Clark, Gavin Band, Geraldine Clarke, Kate Rowlands, Christina Hubbart, Anna Jeffreys, Silvia Kariuki, Kevin Marsh, Margaret MackinnonSummaryBackgroundHuman genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells&...
Source: The Lancet Haematology - July 20, 2018 Category: Hematology Source Type: research

Fever and Rash: Revisiting Measles.
We describe the case of a 44 year-old Portuguese woman who presented with fever, conjunctivitis, cough and rash, rapidly evolving to hepatitis and extensive pneumonia with respiratory failure. Although she claimed to be vaccinated according to the national immunisation schedule, a final diagnosis of primary measles pneumonia was clinically made and confirmed by serology. However, some less typical features mislead us initially. Although the rare form of primary measles pneumonia is more prevalent among immunosuppressed patients, our patient was immunocompetent. Moreover, absence of contagiousness, ...
Source: Acta Medica Portuguesa - July 20, 2018 Category: General Medicine Tags: Acta Med Port Source Type: research

Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection
Sapana Kadel, Susan Kovats (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - July 20, 2018 Category: Allergy & Immunology Source Type: research

Response of the cDC1 and cDC2 subtypes of tracheal dendritic cells to porcine reproductive and respiratory syndrome virus
Publication date: Available online 19 July 2018Source: Veterinary MicrobiologyAuthor(s): Mónica Reséndiz, Olivia Valenzuela, Jesús HernándezAbstractPorcine reproductive and respiratory syndrome virus (PRRSV) is the most important disease affecting the swine industry worldwide. Although monocytes and macrophages, especially tissue-resident and alveolar macrophages, are the primary target of PRRSV, monocyte- and bone marrow-derived dendritic cells (DCs) are also susceptible to PRRSV infection. It has been shown that lung DCs cannot be infected with PRRSV, but the response and susceptibility of bon...
Source: Veterinary Microbiology - July 20, 2018 Category: Veterinary Research Source Type: research

Recurrent diffuse lung disease due to surfactant protein C deficiency
We present the case of a patient with diffuse lung disease who was successfully treated with hydroxychloroquine and steroids in infancy, who presented again as a young adult with respiratory symptoms. Exome sequencing identified a novel de novo SFTPC mutation (c.397A > C p.S133R). Mutated SP-C accumulates and leads to injury of alveolar type II cells, which normally replenish alveolar type I cells after injury. This may explain the symptom recurrence after lung injury in young adulthood. Although hydroxychloroquine has been hypothesized to interfere with mutated SP-C accumulation, data on long term outcome remains l...
Source: Respiratory Medicine Case Reports - July 20, 2018 Category: Respiratory Medicine Source Type: research

One-year mortality among newly admitted older patients in a long-term care hospital in South Korea.
CONCLUSION: At admission, proper assessment and planning for older patients at risk are beneficial to minimise negative consequences. The roles of LTC hospitals need further discussion. PMID: 30028560 [PubMed - as supplied by publisher] (Source: Australasian Journal on Ageing)
Source: Australasian Journal on Ageing - July 20, 2018 Category: Geriatrics Authors: Kim MS, Shin DS, Kim S Tags: Australas J Ageing Source Type: research

Nocardioides currus sp. nov., isolated from a mobile car air-conditioning system.
Abstract A strictly aerobic Gram-stain-positive bacterial strain, designated IB-3T, was isolated from a car air-conditioning system in the Republic of Korea. Cells were non-motile rods showing catalase- and oxidase-positive reactions. Growth of IB-3T was observed at 20-40 °C (optimum, 25 °C), at pH 6.5-9.0 (optimum, pH 7.5) and in the presence of 0-1 % (w/v) NaCl (optimum, 0 %). Menaquinone-8 (H4) was detected as the predominant respiratory quinone and iso-C16 : 0, 10-methyl-C17 : 0, iso-C17 : 0, C18 : 1ω9c, C17 : 1ω8c, C18 : 0, 10-methyl-C18 : 0 (T...
Source: International Journal of Systematic and Evolutionary Microbiology - July 20, 2018 Category: Microbiology Authors: Park YJ, Jeong SE, Jung HS, Park SY, Jeon CO Tags: Int J Syst Evol Microbiol Source Type: research

Hymenobacter rufus sp. nov., a bacterium isolated from soil.
Abstract A bacterial strain, S1-2-2-6T, was isolated from a soil sample collected in Jeollabuk-do province, Republic of Korea. Cells of this strain were observed to be Gram-stain-negative, short and rod-shaped, and colonies were red to pink in colour. Analysis of 16S rRNA gene sequences identified this strain as representing a member of the genus Hymenobacter in the family Cytophagaceae, with the highest levels of sequence similarity being observed in relation to Hymenobacter terrae DG7AT (98.2 %), Hymenobacter rubidus DG7BT (97.9 %), Hymenobacter soli PB17T (97.7 %), and Hymenobacter daeguensis 16F3Y-2T (97...
Source: International Journal of Systematic and Evolutionary Microbiology - July 20, 2018 Category: Microbiology Authors: Ohn JE, Ten LN, Kim BO, Cho YJ, Jung HY Tags: Int J Syst Evol Microbiol Source Type: research

Thalassospira marina sp. nov., isolated from surface seawater.
Abstract Two novel marine bacteria, designated strains CSC3H3T and CSC1P2, were isolated from surface seawater of the South China Sea. Both strains were Gram-negative, oxidase-positive, catalase-positive, curved rods and motile. They grew at 10-40 °C, pH 5-10 and in the presence of 0-15 % (w/v) NaCl. Their 16S rRNA gene sequences were identical to each other. Phylogenetic analysis based on 16S rRNA gene sequences indicated that they belong to the genus Thalassospira, and shared 97.5-98.3 % sequence similarity to all other validly type strains of the genus Thalassospira, and the highest simila...
Source: International Journal of Systematic and Evolutionary Microbiology - July 20, 2018 Category: Microbiology Authors: Dong C, Liu R, Lai Q, Liu Y, Shao Z Tags: Int J Syst Evol Microbiol Source Type: research