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Host Factors in Coronavirus Replication.
Authors: de Wilde AH, Snijder EJ, Kikkert M, van Hemert MJ Abstract Coronaviruses are pathogens with a serious impact on human and animal health. They mostly cause enteric or respiratory disease, which can be severe and life threatening, e.g., in the case of the zoonotic coronaviruses causing severe acute respiratory syndrome (SARS) and Middle East Respiratory Syndrome (MERS) in humans. Despite the economic and societal impact of such coronavirus infections, and the likelihood of future outbreaks of additional pathogenic coronaviruses, our options to prevent or treat coronavirus infections remain very limited. This...
Source: Current Topics in Microbiology and Immunology - June 25, 2017 Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research

Guillain-Barr é Syndrome After Elective Spinal Surgery.
Guillain-Barré Syndrome After Elective Spinal Surgery. J Am Acad Orthop Surg. 2017 Jun 21;: Authors: Chen EY, Stratton C, Mercer B, Hohler A, Tannoury TY, Tannoury C Abstract Guillain-Barré syndrome is a rare autoimmune condition characterized by ascending motor weakness of the extremities that can ascend to the diaphragm, causing substantial morbidity and mortality. This case report describes a 57-year-old man who exhibited characteristics of Guillain-Barré syndrome 9 days after undergoing lumbar fusion at L3-S1. The diagnosis was based on the patient's ascending motor weakness an...
Source: The Journal of the American Academy of Orthopaedic Surgeons - June 25, 2017 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Fluid filling of the digestive tract for improved proton resonance frequency shift ‐based MR thermometry in the pancreas
ConclusionPreparation of the digestive tract near the pancreas by filling it with fluid improved MR thermometry precision and accuracy for all common respiratory motion‐compensated methods evaluated. These improvements are attributed to reducing field inhomogeneity in the pancreas.Level of Evidence: 2Technical Efficacy: Stage 1J. Magn. Reson. Imaging 2017. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - June 24, 2017 Category: Radiology Authors: Cyril J. Ferrer, Lambertus W. Bartels, Marijn Stralen, Baudouin Senneville, Chrit T.W. Moonen, Clemens Bos Tags: Original Research Source Type: research

Extraoral Taste Receptor Discovery: New Light on Ayurvedic Pharmacology.
Authors: Gilca M, Dragos D Abstract More and more research studies are revealing unexpectedly important roles of taste for health and pathogenesis of various diseases. Only recently it has been shown that taste receptors have many extraoral locations (e.g., stomach, intestines, liver, pancreas, respiratory system, heart, brain, kidney, urinary bladder, pancreas, adipose tissue, testis, and ovary), being part of a large diffuse chemosensory system. The functional implications of these taste receptors widely dispersed in various organs or tissues shed a new light on several concepts used in ayurvedic pharmacology (dr...
Source: Evidence-based Complementary and Alternative Medicine - June 24, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Effect of Baseline Anxiety and Depression Symptoms on Selected Outcomes Following Pulmonary Rehabilitation.
This study sought to quantify the influence of varying degrees of anxiety and depression on functional performance and disease impact in a population with CRDs following pulmonary rehabilitation (PR) intervention. METHODS: The Hospital Anxiety and Depression Scale (HADS), the 6-Minute Walk Test (6MWT), and the Chronic Obstructive Pulmonary Disease Assessment Test (CAT) were assessed pre- and post-PR. Participants were categorized into 3 groups (None, Probable, and Present) based on their level of anxiety and depression. Functional performance and disease impact outcomes were compared pre- and post-PR. RESULTS: Pa...
Source: Journal of Cardiopulmonary Rehabilitation and Prevention - June 24, 2017 Category: Rehabilitation Authors: Cullen K, Talbot D, Gillmor J, McGrath C, OʼDonnell R, Baily-Scanlan M, Broderick J Tags: J Cardiopulm Rehabil Prev Source Type: research

Acute Respiratory Distress Syndrome in Pregnant Women.
PMID: 28644319 [PubMed - in process] (Source: Obstetrics and Gynecology)
Source: Obstetrics and Gynecology - June 24, 2017 Category: OBGYN Authors: Catanzarite V Tags: Obstet Gynecol Source Type: research

Foregut Duplication Cysts in Children.
CONCLUSIONS: Foregut malformation in children may present with a variety of symptoms or can be found incidentally. The decision and timing of surgery is based on the clinical presentation. Surgical intervention in asymptomatic patients should be based on a thorough discussion with the parents. PMID: 28642639 [PubMed - in process] (Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons)
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - June 24, 2017 Category: Surgery Tags: JSLS Source Type: research

Monitoring Opioid-Induced Respiratory Depression.
PMID: 28644265 [PubMed - in process] (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - June 24, 2017 Category: Nursing Authors: Hinds J Tags: Am J Nurs Source Type: research

Monitoring Opioid-Induced Respiratory Depression.
PMID: 28644266 [PubMed - in process] (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - June 24, 2017 Category: Nursing Authors: Gaines N Tags: Am J Nurs Source Type: research

Monitoring Opioid-Induced Respiratory Depression
No abstract available (Source: AJN)
Source: AJN - June 24, 2017 Category: Nursing Tags: Letters, etc Source Type: research

Intravenous Alteplase for Acute Stroke and Pulmonary Embolism in a Patient With Recent Abdominoplasty
Conclusions: Interdisciplinary collaboration can successfully inform the decision to treat acute ischemic stroke with IV alteplase in the setting of recent major surgery. (Source: The Neurologist)
Source: The Neurologist - June 24, 2017 Category: Neurology Tags: Case Report/Case Series Source Type: research

Invasive Pneumococcal Disease in Patients With Sickle Cell Disease
Conclusions: Breakthrough cases of IPD may involve nonvaccine isolates, and seem to occur after 5 years of age when oral penicillin prophylaxis has been terminated. (Source: Journal of Pediatric Hematology Oncology)
Source: Journal of Pediatric Hematology Oncology - June 24, 2017 Category: Hematology Tags: Original Articles Source Type: research

Risk Factors for Severe Respiratory Depression from Prescription Opioid Overdose
This study was conducted at two urban academic emergency departments in New York City, USA. ParticipantsAdult patients who presented with acute prescription opioid overdose between 2009 and 2013 were included in the current study. We analysed 307 patients (mean age 44.7, 42% female, 2.0% mortality). MeasurementsPatient demographics, reported substances ingested, suspected intent for ingesting the substance, vital signs, laboratory data, treatments including antidotes and intubation, and outcome of death were recorded by trained research assistants. Intent was categorized into four mutually exclusive categories: suicide, mi...
Source: Addiction - June 24, 2017 Category: Addiction Authors: Lindsay M. Fox, Robert S. Hoffman, David Vlahov, Alex F. Manini Tags: Research Report Source Type: research

Contribution of non- influenza respiratory viruses in causation of Influenza like Illness (ILI) during influenza epidemic; a laboratory based study
Conclusion Even during an epidemic other respiratory viruses contribute substantially to ILI (Source: Clinical Epidemiology and Global Health)
Source: Clinical Epidemiology and Global Health - June 24, 2017 Category: Epidemiology Source Type: research

Role of P2X7R in the development and progression of pulmonary hypertension
Pulmonary arterial hypertension (PAH) is a devastating disease that lacks sufficient treatment. Studies have shown that the Nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome contributes ... (Source: Respiratory Research)
Source: Respiratory Research - June 24, 2017 Category: Respiratory Medicine Authors: Jie Yin, Shuling You, Haopeng Liu, Li Chen, Chengdong Zhang, Hesheng Hu, Mei Xue, Wenjuan Cheng, Ye Wang, Xinran Li, Yugen Shi, Nannan Li, Suhua Yan and Xiaolu Li Source Type: research

Curcumin Alleviates Macrophage Activation and Lung Inflammation Induced by Influenza Virus Infection through Inhibiting the NF ‐κB Signaling Pathway
ConclusionsIn summary, IAV infection could result in the inflammatory responses of immune cells, especially macrophages. Curcumin has the therapeutic potentials to relieve these inflammatory responses through inhibiting the NF‐κB signaling pathway.This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - June 24, 2017 Category: Virology Authors: Yiming Xu, Ling Liu Tags: Original Article Source Type: research

Association Between CD4 + , Viral Load, and Pulmonary Function in HIV
AbstractPurposeThe antiretroviral therapy era has shifted the epidemiology of HIV-associated diseases, increasing the recognition of non-infectious pulmonary complications secondary to HIV. We aimed to determine the association between CD4+, viral load, and pulmonary function in individuals with uncontrolled HIV, and determine how changes in these parameters are associated with pulmonary function longitudinally.MethodsThis is a retrospective observational study of individuals with HIV who underwent pulmonary function testing in an urban medical center between August 1997 and November 2015.ResultsOf the 146 participants (me...
Source: Lung - June 24, 2017 Category: Respiratory Medicine Source Type: research

Improving the response to toxic inhalation disasters
Publication date: Available online 23 June 2017 Source:The Lancet Respiratory Medicine Author(s): Talha Khan Burki (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Source Type: research

Antacid therapy in idiopathic pulmonary fibrosis: more questions than answers?
Publication date: July 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 7 Author(s): Kerri A Johannson, Irina Strâmbu, Claudia Ravaglia, Jan C Grutters, Claudia Valenzuela, Nesrin Mogulkoc, Fabrizio Luppi, Luca Richeldi, Athol U Wells, Carlo Vancheri, Michael Kreuter Idiopathic pulmonary fibrosis (IPF) is a progressive parenchymal lung disease of complex cause. Gastro-oesophageal reflux (GER) and microaspiration have been proposed as risk factors for the development and progression of IPF, but robust definitive data are few. A recent international guideline conditionally recommended the use of antacid th...
Source: The Lancet Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Source Type: research

Clearing the air: do facemasks protect health?
Publication date: July 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 7 Author(s): Aaron van Dorn (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Source Type: research

Fighting for health: meet the doctor-activists
Publication date: July 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 7 Author(s): Talha Khan Burki (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Source Type: research

Australia's respiratory health in focus
Publication date: July 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 7 Author(s): Tony Kirby (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Source Type: research

The TRINITY study: Twitter discussion from a respirology journal club – Authors' reply
Publication date: July 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 7 Author(s): Jørgen Vestbo (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Source Type: research

The TRINITY study: Twitter discussion from a respirology journal club
Publication date: July 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 7 Author(s): Melissa Brijbassi, Anju Anand, Matthew Stanbrook (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Source Type: research

Lung volume reduction for emphysema – Authors' reply
Publication date: July 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 7 Author(s): Wouter H van Geffen, Felix J Herth, Gaetan Deslee, Dirk-Jan Slebos, Pallav L Shah (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Source Type: research

Vocal cord dysfunction or inducible laryngeal obstruction: whatever it is, it exists
Publication date: July 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 7 Author(s): Felix J F Herth, Maren Schuhmann (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Source Type: research

Controversies and conundrums in vocal cord dysfunction
Publication date: July 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 7 Author(s): Philip G Bardin, Kathy Low, Laurence Ruane, Kenneth K Lau (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Source Type: research

Clinical trial research in focus: improving drug development and trial design in pulmonary arterial hypertension
Publication date: July 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 7 Author(s): Annie Christine Lajoie, Sebastien Bonnet, Steeve Provencher (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Source Type: research

Maximal bronchodilation: a therapeutic target in COPD?
Publication date: July 2017 Source:The Lancet Respiratory Medicine, Volume 5, Issue 7 Author(s): Alvar Agustí, PN Richard Dekhuijzen (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Source Type: research

An uncommon cause of pneumonia: The golden diagnosis
Publication date: 2017 Source:Respiratory Medicine Case Reports, Volume 22 Author(s): Laura Fabbri, Roberto Tonelli, Alessandro Andreani, Ivana Castaniere, Riccardo Fantini, Alessandro Marchioni, Enrico M. Clini A 28-year-old sub-Saharan African Italian non-smoker male presented with signs and symptoms of pneumonia and respiratory failure. Despite antibiotic treatment he experienced a significant worsening of respiratory conditions and admission to intensive care unit. He thus underwent chest computed tomography followed by fiberopict bronchoscopy with bronchoalveolar lavage whose macroscopic examination led to the diagno...
Source: Respiratory Medicine Case Reports - June 24, 2017 Category: Respiratory Medicine Source Type: research

Characteristics of Mycobacterium avium complex (MAC) pulmonary disease in previously treated lung cancer patients
Conclusion MAC pulmonary disease in previously treated lung cancer can occur without apparent risk factors for this NTM infection. Symptomatic improvement with MAC antimicrobial therapy appears to be lower than expected but comorbidities might influence outcomes in this patient population. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - June 24, 2017 Category: Respiratory Medicine Source Type: research

Respiratory diphtheriae due to Corynebacterium ulcerans transmitted by a companion dog, Italy 2014
AbstractA serious respiratory tract infection due toCorynebacterium ulcerans was observed in a 70-year-old woman. Clinical presentation included pseudomembranes in the upper respiratory tract and lung involvement.C. ulcerans was recovered from the nose of the patient ’s dog. Both dog’s and patient’s isolates belonged to Sequence Type 331. (Source: Infection)
Source: Infection - June 24, 2017 Category: Infectious Diseases Source Type: research

Oral papillomatosis in immunocompromised patients: A case series of kidney transplantation recipients and myelodysplastic syndrome
Solitary papilloma is a human papillomavirus (HPV) induced benign indolent epithelial tumor with limited growth, whereas papillomatosis is an entirely different story. Papillomatosis needs attention due to its aggressive and recurrent clinical progress with risks of dysplastic and malignant transformation. Recurrent respiratory papillomatosis (RRP) has a high prevalence of dysplasia and reports of transformation to carcinoma-ex-papillomatosis, especially when associated with low risk HPV type 11. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - June 24, 2017 Category: ENT & OMF Authors: Eun-Jung Kwak, Yun Hee Choi, Wonse Park, Eunae Sandra Cho Tags: Case Report Source Type: research

Can the analysis of built-in software of CPAP devices replace polygraphy in children?
Polysomnography (PSG) is the gold standard for the scoring of residual respiratory events during continuous positive airway pressure (CPAP). Studies comparing PSG scoring with automatic scoring by the built-in software of CPAP devices have reported acceptable agreements except for the hypopnea index (HI) in adult patients, but no study has yet been conducted in children. The aim of the present study was to compare the automatic scoring by CPAP device and manual scoring using the software tracings of the CPAP device integrating pulse oximetry (SpO2) with in-lab polygraphy (PG). (Source: Sleep Medicine)
Source: Sleep Medicine - June 24, 2017 Category: Sleep Medicine Authors: Sonia Khirani, Vincent Delord, Jorge Olmo Arroyo, Livio De Sanctis, Annick Frapin, Alessandro Amaddeo, Brigitte Fauroux Source Type: research

People attending pulmonary rehabilitation demonstrate a substantial engagement with technology and willingness to use telerehabilitation: a survey
Conclusion People attending metropolitan pulmonary rehabilitation, maintenance exercise classes and support groups had substantial technology engagement, with high device access and use, and good self-rated technology competence. The majority of participants were willing to use telerehabilitation, especially if they were regular users of technology devices. [Seidman Z, McNamara R, Wootton S, Leung R, Spencer L, Dale M, Dennis S, McKeough Z (2017) People attending pulmonary rehabilitation demonstrate a substantial engagement with technology and willingness to use telerehabilitation: a survey. Journal of Physiotherapy XX: XX...
Source: Journal of Physiotherapy - June 24, 2017 Category: Physiotherapy Source Type: research

Extracellular cytochrome c as an intercellular signaling molecule regulating microglial functions
Conclusions Extracellular cytochrome c can interact with microglia TLR4 and modulate select functions of these brain immune cells. General significance Our data identifies extracellular cytochrome c as a potential intercellular signaling molecule, which may be recognized by microglia causing or enhancing their immune activation. The data obtained support targeting TLR4 and JNK signaling as potential treatment strategies for brain diseases characterized by excessive cellular death and activation of microglia. (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - June 24, 2017 Category: Biochemistry Source Type: research

Sulfated dehydropolymer of caffeic acid: In vitro anti-lung cell death activity and in vivo intervention in emphysema induced by VEGF receptor blockade
Publication date: Available online 23 June 2017 Source:Pulmonary Pharmacology & Therapeutics Author(s): Tien M. Truong, Hua Li, Sneha Dhapare, Umesh R. Desai, Nobert F. Voelkel, Masahiro Sakagami Induced lung cell death and impaired hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) signaling are proposed as a pathobiologic mechanism for alveolar structural destruction and loss in emphysema. We hypothesized that our sulfated dehydropolymer of caffeic acid, CDSO3, exerts anti-cell death activities and therapeutic interventions in emphysema by virtue of Fe2+ chelation-base...
Source: Pulmonary Pharmacology and Therapeutics - June 24, 2017 Category: Respiratory Medicine Source Type: research

A single bout of maximal exercise improves lung function in patients with cystic fibrosis
Responses to a single bout of exercise may provide critical information for maximizing improvements in pulmonary function following exercise training in cystic fibrosis (CF). We sought to determine if acute maximal exercise improves pulmonary function in patients with CF. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - June 24, 2017 Category: Respiratory Medicine Authors: Matthew A. Tucker, Reva Crandall, Nichole Seigler, Paula Rodriguez-Miguelez, Kathleen T. McKie, Caralee Forseen, Jeffrey Thomas, Ryan A. Harris Source Type: research

The influence of head-of-bed elevation in patients with obstructive sleep apnea
AbstractPurposeThe purpose of this study is to test the effects of a mild degree of head-of-bed elevation (HOBE) (7.5 °) on obstructive sleep apnea (OSA) severity and sleep quality.MethodsOSA patients were recruited from a single sleep clinic (Crici úma, Santa Catarina, Brazil). Following a baseline polysomnography (PSG), all patients underwent a PSG with HOBE (within 2 weeks). In addition, a subset of patients performed a third PSG without HOBE.ResultsFifty-two patients were included in the study (age 53.2  ± 9.1 years; BMI 29.6 ± 4.8 kg/m2, neck circumference 38...
Source: Sleep and Breathing - June 24, 2017 Category: Respiratory Medicine Source Type: research

A clinicopathological study of surgically resected lung cancer in patients with usual interstitial pneumonia
This study aimed to elucidate a characteristic pathological feature of lung cancer that develops in patients with UIP, with a focus on the location of its onset. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Authors: Yasutaka Watanabe, Yoshinori Kawabata, Nobuyuki Koyama, Tomohiko Ikeya, Eishin Hoshi, Noboru Takayanagi, Shinichiro Koyama Source Type: research

Initiating or changing to a fixed-dose combination of Fluticasone propionate/Formoterol over Fluticasone propionate/Salmeterol: A real-life effectiveness and cost impact evaluation
Asthma has a substantial impact on quality of life and health care resources. The identification of a more cost-effective, yet equally efficacious, treatment could positively influence the economic burden of this disease. Fluticasone propionate/Formoterol (FP/FOR) may be as effective as Fluticasone Salmeterol (FP/SAL). We evaluated non-inferiority of asthma control in terms of the proportion of patients free from exacerbations, and conducted a cost impact analysis. (Source: Respiratory Medicine)
Source: Respiratory Medicine - June 24, 2017 Category: Respiratory Medicine Authors: Simon Wan Yau Ming, John Haughney, Iain Small, Stephanie Wolfe, John Hamill, Kevin Gruffydd-Jones, Cathal Daly, Joan B. Soriano, Elizabeth Gardener, Derek Skinner, Martina Stagno d'Alcontres, David B. Price Source Type: research

Acromegaly discovered during a routine out-patient surgical procedure: a case report
ConclusionsThis case underscores the notable absence of recognizing the clinical presentation of acromegaly in this patient by his primary care physician, and the value of thorough history taking, vigilance, and observation in making a new diagnosis that has the potential to alter a patient ’s health care and mitigate impending morbidity and/or mortality. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - June 24, 2017 Category: General Medicine Source Type: research

Sepsis favors high-on-clopidogrel platelet reactivity.
Authors: Akinosoglou K, Perperis A, Theodoraki S, Alexopoulos D, Gogos C Abstract High-on-treatment platelet reactivity (HPR) is associated with ischemic events in patients on antiplatelet therapy with a history of cardiovascular disease. On the other hand, recent data have associated sepsis with adverse cardiovascular events in patients admitted with bacteremia or respiratory infection. We aimed to assess P2Y12-mediated platelet reactivity (PR) during sepsis and recovery in patients under clopidogrel. This was a prospective observational study. Incoming patients presenting with signs/symptoms of sepsis already on ...
Source: Platelets - June 23, 2017 Category: Hematology Tags: Platelets Source Type: research

The effects of the introduction of an adult ECMO program on statewide referral patterns, casemix and outcomes in patients with acute respiratory distress syndrome or pneumonia
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 23, 2017 Category: Intensive Care Source Type: research

Early Halt of a Randomized Controlled Study with 3% Hypertonic Saline in Acute Bronchiolitis
Conclusion: No beneficial effects and possibly severe adverse events are observed with 3% hypertonic saline in the treatment of bronchiolitis.Respiration (Source: Respiration)
Source: Respiration - June 23, 2017 Category: Respiratory Medicine Source Type: research

Effect of Baseline Anxiety and Depression Symptoms on Selected Outcomes Following Pulmonary Rehabilitation
This study sought to quantify the influence of varying degrees of anxiety and depression on functional performance and disease impact in a population with CRDs following pulmonary rehabilitation (PR) intervention. Methods: The Hospital Anxiety and Depression Scale (HADS), the 6-Minute Walk Test (6MWT), and the Chronic Obstructive Pulmonary Disease Assessment Test (CAT) were assessed pre- and post-PR. Participants were categorized into 3 groups (None, Probable, and Present) based on their level of anxiety and depression. Functional performance and disease impact outcomes were compared pre- and post-PR. Results: Patients c...
Source: Journal of Cardiopulmonary Rehabilitation - June 23, 2017 Category: Rehabilitation Tags: Pulmonary Rehabilitation Source Type: research

Comorbidities in Patients With Chronic Obstructive Pulmonary Disease and Pulmonary Rehabilitation Outcomes
Conclusion: Patients with cardiac disease experienced greater improvement in the dyspnea score compared with patients with no cardiac disease, whereas patients with orthopedic problems had a smaller but also clinically significant improvement in dyspnea after pulmonary rehabilitation. (Source: Journal of Cardiopulmonary Rehabilitation)
Source: Journal of Cardiopulmonary Rehabilitation - June 23, 2017 Category: Rehabilitation Tags: Pulmonary Rehabilitation Source Type: research

Implementation and Outcomes of a Community-Based Pulmonary Rehabilitation Program in Rural Appalachia
Purpose: To report on the implementation and clinical outcomes of a community-based pulmonary rehabilitation program in rural Appalachia. Methods: Three rural health centers and a large referral hospital worked together to establish pulmonary rehabilitation services based on AACVPR guidelines. Each site hired at least 1 respiratory therapist. To measure clinical outcomes, a retrospective medical record study compared pre- and post-program values for the modified Medical Research Council dyspnea level, 6-minute walk test (6MWT), negative inspiratory force (NIF), respiratory disease knowledge, St George Respiratory Question...
Source: Journal of Cardiopulmonary Rehabilitation - June 23, 2017 Category: Rehabilitation Tags: Brief Report Source Type: research

Bilateral Large Pneumothoraxes Following Implantable Cardioverter-Defibrillator Generator Change: A Case Report of an Uncommon Event Complicating a Common Procedure.
We report an unusual case of a patient developing spontaneous bilateral large pneumothoraxes after an implantable cardioverter-defibrillator generator and lead revision without evidence of any obvious traumatic cardiac injury. CASE PRESENTATION: A 79-year-old white man was scheduled for implantable cardioverter-defibrillator generator change and addition of an atrial lead. Approximately one hour after the procedure, he suddenly went into respiratory distress with profuse sweating, and pallor with falling oxygen saturation and blood pressure. Chest x-ray showed bilateral large pneumothoraxes. DISCUSSION: In our lite...
Source: The Permanente journal - June 23, 2017 Category: General Medicine Tags: Perm J Source Type: research