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A retrospective study of clinico-epidemiological profile of snakebite related deaths at a Tertiary care hospital in Midnapore, West Bengal, India
Conclusion Snake bite is a neglected, life-threatening emergency in developing countries such as India and demands immediate anti-venom therapy. Hospital studies are a key source of information about snake bites. The ready availability and appropriate use of AVS, close monitoring of patients, the institution of ventilator support and if required, early referral to a larger hospital all help to reduce the mortality. Thus knowledge of the varied clinical manifestations of snake bite is important for effective management in hospitals by a complete health care team. Graphical abstract (Source: Toxicology Reports)
Source: Toxicology Reports - November 25, 2017 Category: Toxicology Source Type: research

Mechanical ventilation in acute respiratory distress syndrome: The open lung revisited
Publication date: December 2017 Source:Medicina Intensiva (English Edition), Volume 41, Issue 9 Author(s): L. Amado-Rodríguez, C. del Busto, E. García-Prieto, G.M. Albaiceta Acute respiratory distress syndrome (ARDS) is still related to high mortality and morbidity rates. Most patients with ARDS will require ventilatory support. This treatment has a direct impact upon patient outcome and is associated to major side effects. In this regard, ventilator-associated lung injury (VALI) is the main concern when this technique is used. The ultimate mechanisms of VALI and its management are under constant evolution. ...
Source: Medicina Intensiva - November 25, 2017 Category: Intensive Care Source Type: research

Introduction: 2017 Taiwan Association of Thoracic & Cardiovascular Surgery.
Introduction: 2017 Taiwan Association of Thoracic & Cardiovascular Surgery. J Thorac Dis. 2017 Oct;9(Suppl 14):S1397-S1398 Authors: Chen YS, Lee JM, Chao YK PMID: 29167749 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - November 24, 2017 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Exhaled and nasal nitric oxide in chronic rhinosinusitis patients with nasal polyps in primary care.
CONCLUSION: Subclinical eosinophilic lower airway inflammation is common in CRSwNP in the primary sector, even in the absence of asthma. PMID: 29166423 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - November 24, 2017 Category: ENT & OMF Tags: Rhinology Source Type: research

Clinical analysis of 59 children with hand foot and mouth diseases due to enterovirus EV71 and concomitant viral encephalitis.
CONCLUSIONS: HFMD and the complicated viral encephalitis usually occurred in the children
Source: European Review for Medical and Pharmacological Sciences - November 24, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The clinical effects of combined use of inhaled nitric oxide at early stage to cure severe respiratory failure in neonates.
Authors: Wang W, Li ZG, Liu G, Xue L Abstract OBJECTIVE: To observe the clinical effects of combined use of inhaled nitric oxide at the early stage to cure severe respiratory failure in neonates. PATIENTS AND METHODS: 45 cases of neonates with severe respiratory failure, who were admitted to the neonatal intensive care unit (NICU) of XuZhou Children's Hospital from November 2014 to February 2016, were selected as objects of study, namely the iNO treatment group. On the basis of conventional treatment and mechanical ventilation, all of them were treated with the combined use of iNO at the early stage. The arteri...
Source: European Review for Medical and Pharmacological Sciences - November 24, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

CPAP by helmet for treatment of acute respiratory failure after pediatric liver transplantation
Abstract ARF after pediatric liver transplantation accounts for high rate of morbidity and mortality associated with this procedure. The role of CPAP in postoperative period is still unknown. The aim of the study was to describe current practice and risk factors associated with the application of helmet CPAP. In this retrospective observational cohort study, 119 recipients were divided into two groups based on indication to CPAP after extubation. Perioperative variables were studied, and determinants of CPAP application were analyzed in a multivariate logistic model. Sixty patients (60/114) developed ARF and were included ...
Source: Pediatric Transplantation - November 24, 2017 Category: Transplant Surgery Authors: F. Chiusolo, V. Fanelli, M. L. Ciofi degli Atti, G. Conti, F. Tortora, R. Pariante, L. Rav à, C. Grimaldi, J. Ville de Goyet, S. Picardo Tags: ORIGINAL ARTICLE Source Type: research

Application of Electrocautery Needle Knife Combined with Balloon Dilatation versus Balloon Dilatation in the Treatment of Tracheal Fibrotic Scar Stenosis
Conclusion: Electrocautery needle knife combined with balloon dilatation is an effective and safe treatment for tracheal fibrotic stenosis compared with balloon dilatation alone.Respiration (Source: Respiration)
Source: Respiration - November 24, 2017 Category: Respiratory Medicine Source Type: research

Extracorporeal membrane oxygenation (ECMO) during pregnancy and postpartum
Extracorporeal membrane oxygenation (ECMO) can provide respiratory support (VV-ECMO) or both respiratory and circulatory support (VA-ECMO). The use of ECMO has increased dramatically as a result of simpler technology. No level I evidence is yet available reflecting improved outcomes with ECMO. The use of this technology during pregnancy may be indicated in very select cases and should be delivered in centers with dedicated ECMO specialized units. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - November 24, 2017 Category: Perinatology & Neonatology Authors: Luis D. Pacheco, George R. Saade, Gary D.V. Hankins Source Type: research

FAM13A is a modifier gene of cystic fibrosis lung phenotype regulating rhoa activity, actin cytoskeleton dynamics and epithelial-mesenchymal transition
Cystic fibrosis (CF) lung disease severity is highly variable and dependent on several factors including genetic modifiers. Family with sequence similarity 13 member A (FAM13A) has been previously associated with lung function in the general population as well as in several chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), we examined whether FAM13A is a modifier gene of CF lung phenotype. We also studied how FAM13A may contribute to the physiopathological mechanisms associated with CF. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - November 24, 2017 Category: Respiratory Medicine Authors: Harriet Corvol, Nathalie Rousselet, Kristin E. Thompson, Laura Berdah, Guillaume Cottin, Tobias Foussigniere, Elisabeth Longchampt, Laurence Fiette, Edouard Sage, C éline Prunier, Mitchell Drumm, Craig A. Hodges, Pierre-Yves Boëlle, Loic Guillot Tags: Original Article Source Type: research

Rapid and sensitive method for simultaneous determination of first-line anti-tuberculosis drugs in human plasma by HPLC-MS/MS: Application to therapeutic drug monitoring
First-line anti-tuberculosis drugs are playing vital roles for curbing rapid spread of tuberculosis. Multidrug therapies are commonly applied in clinical to achieve better treatment outcomes. However, drug resistance and adverse reactions come along with this therapies and therapeutic drug monitoring is a feasible way to precaution them. For this reasons, a simple and sensitive method based on liquid chromatography-tandem mass spectroscopy (LC-MS/MS) and single protein precipitation was developed and validated for simultaneously quantifying of pyrazinamide, isoniazid, ethambutol, streptomycin and rifampicin in human plasma...
Source: Tuberculosis - November 24, 2017 Category: Respiratory Medicine Authors: Shouhong Gao, Zhipeng Wang, Xinfang Xie, Chunhua You, Yang Yang, Yanhai Xi, Wansheng Chen Source Type: research

Modulation of iron status biomarkers in tuberculosis-diabetes co-morbidity
Tuberculosis (TB) and diabetes mellitus (DM) remain vital disease burdens in developing countries and the dual burden of DM and TB clearly signifies a growing global public health concern. While modulation of iron status biomarkers in TB is well described, very little is known about the association of these markers with TB-DM. To examine the association of circulating iron status biomarkers in TB disease, we examined the systemic levels of ferritin, hepcidin, soluble transferrin receptor (sTfR), transferrin, apotransferrin and hemopexin in pulmonary TB (PTB) individuals with DM (PTB-DM), without DM (PTB) and those with dia...
Source: Tuberculosis - November 24, 2017 Category: Respiratory Medicine Authors: Nathella Pavan Kumar, Vaithilingam V. Banurekha, Dina Nair, Chandrakumar Dolla, Paul Kumaran, Subash Babu Source Type: research

Killer (FASL regulatory) B cells are present during latent TB and are induced by BCG stimulation in participants with and without latent tuberculosis
Regulatory B cells (Bregs) have been shown to be present during several disease states. The phenotype of the cells is not completely defined and the function of these cells differ between disease. The presence of FASL expressing (killer) B cells during latent and successfully treated TB disease have been shown but whether these cells are similar to regulatory B cells remain unclear. We assessed the receptor expression of FASL/IL5 (killer B cells), CD24/CD38 (regulatory B cells) on whole peripheral blood of participants with untreated active TB and healthy controls. (Source: Tuberculosis)
Source: Tuberculosis - November 24, 2017 Category: Respiratory Medicine Authors: Ilana C. van Rensburg, A.G. Loxton Source Type: research

Letter to the Editor: Serum surfactant protein D predicts the outcome of patients with idiopathic pulmonary fibrosis treated with pirfenidone
We took an interest to read the above-published article conducted by Ikeda K and colleagues that was published in Respiratory Medicine recently [1]. This was a well-written article. To make the results more accuracy and convincing, some statistical methods should be reconsidered seriously. (Source: Respiratory Medicine)
Source: Respiratory Medicine - November 24, 2017 Category: Respiratory Medicine Authors: Jie Weng, Mengyun Tu, Bo Yang, Zhiyi Wang Tags: Correspondence Source Type: research

Several high-resolution computed tomography findings associate with survival and clinical features in rheumatoid arthritis-associated interstitial lung disease
To compare the presence and extent of several high-resolution computed tomography (HRCT) observations in different subtypes of rheumatoid arthritis-related interstitial lung disease (RA-ILD) and to examine associations between radiological findings, hospitalization, age, RA duration, pulmonary function tests (PFT) and survival. (Source: Respiratory Medicine)
Source: Respiratory Medicine - November 24, 2017 Category: Respiratory Medicine Authors: Hanna M. Nurmi, Hannu-Pekka Kettunen, Sanna-Katja Suoranta, Minna K. Purokivi, Miia S. K ärkkäinen, Tuomas A. Selander, Riitta L. Kaarteenaho Source Type: research

Review demonstrates that less invasive surfactant administration in preterm neonates leads to fewer complications
ConclusionLess invasive surfactant therapy improves pulmonary outcomes in preterm neonates with RDS and should ideally be administered in combination with CPAP.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - November 24, 2017 Category: Pediatrics Authors: Ludwig Gortner, Simone S. Sch üller, Egbert Herting Tags: Review Article Source Type: research

Pathology and Radiology Correlation of Idiopathic Interstitial Pneumonias
By nature, idiopathic interstitial pneumonias, have been diagnosed in a multidisciplinary manner. As classifications have been subject to significant refinement over the last decade, the importance of correlating clinical, radiologic, and pathologic information in order to arrive at a diagnosis, which will predict prognosis in any given patient, has become increasingly recognized. In 2013, the American Thoracic Society and European Respiratory Society updated the idiopathic interstitial pneumonias classification scheme, addressing the most recent updates in the field. (Source: Human Pathology)
Source: Human Pathology - November 24, 2017 Category: Pathology Authors: Kiran Batra, Yasmeen Butt, Tunc Gokaslan, Daniel Burguete, Craig Glazer, Jose R. Torrealba Tags: Education in pathology Source Type: research

Imaging of respiratory muscles in neuromuscular disease: A review
• Imaging enables to study respiratory muscles in neuromuscular disease• Static imaging techniques include chest radiography, B-mode ultrasound, CT and MRI• Dynamic imaging techniques include fluoroscopy, M-mode ultrasound and MRI• MRI enables studying diaphragmatic movements simultaneously with pulmonary function tests• MRI provides the most detailed information about different respiratory muscles (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - November 24, 2017 Category: Neurology Authors: L. Harlaar, P. Ciet, A.T. van der Ploeg, E. Brusse, N.A.M.E. van der Beek, P.A. Wielopolski, M. de Bruijne, H.A.W.M. Tiddens, P.A. van Doorn Tags: Review Source Type: research

Male with Severe Hypertension and Dyspnea
A 74-year-old man presented to the Emergency Department via ambulance with acute-onset dyspnea while at rest. On arrival the patient was diaphoretic, tachypneic, and in severe respiratory distress, with a blood pressure of 220/125 mm Hg and a heart rate of 130 beats/min. Treatment for presumptive hypertensive emergency with flash pulmonary edema was initiated. Despite continuous positive pressure ventilation and aggressive nitroglycerin dosing, the patient's condition deteriorated and he was intubated. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - November 24, 2017 Category: Emergency Medicine Authors: Nubia Seyoum, Semhar Z. Tewelde, Zachary D.W. Dezman Tags: Visual Diagnosis in Emergency Medicine Source Type: research

Bronchiolitis: What's All the Fuss About?
Bronchiolitis is one of the most common causes of hospitalization for pediatric patients in the United States, with approximately 60,000 patients hospitalized annually (1). Strictly speaking, bronchiolitis is defined as a disease process of the lower respiratory tract, occurring most commonly in children (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - November 24, 2017 Category: Emergency Medicine Authors: Nisa S. Atigapramoj Tags: Editorial Source Type: research

Biosynthesis of cerium oxide nanoparticles and their effect on lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction in male Sprague Dawley rats
Publication date: 1 February 2018 Source:Materials Science and Engineering: C, Volume 83 Author(s): Guoqiang Chen, Yunfei Xu The fetal/life challenging Sepsis is an urgent medical disaster which have developed “blood poisoning”. The sepsis is one of the disorders of organs which cause death in patients. The investigational models that mimicchemical change of sepsis in human bodywereessential. We have synthesized CeO2 NPs using eco-friendly method using plant extract. The characterization of synthesized CeO2 NPs was studied using UV–Vis, FTIR, XRD, SEM, EDX and TEM analysis. The results were confirmed tha...
Source: Materials Science and Engineering: C - November 24, 2017 Category: Materials Science Source Type: research

Panic-like escape response elicited in mice by exposure to CO2, but not hypoxia
Publication date: 2 February 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 81 Author(s): Ailton Spiacci, Heloisa H. Vilela-Costa, Ana Beatriz Sant'Ana, Gabriel Gripp Fernandes, Alana Tercino Frias, Glauber S. Ferreira da Silva, José Antunes-Rodrigues, Hélio Zangrossi Exposure to elevated concentrations of CO2 or hypoxia has been widely used in psychiatric research as a panic provoking stimulus. However, the use of these respiratory challenges to model panic-like responses in experimental animals has been less straightforward. Little data is available, from behavioral and ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 24, 2017 Category: Psychiatry Source Type: research

Corrigendum to “Single-molecule in vivo imaging of bacterial respiratory complexes indicates delocalized oxidative phosphorylation” [Biochim. Biophys. Acta 1837(6) (2014) 811–824 DOI: 10.1016/j.bbabio.2014.01.020]
Publication date: Available online 22 November 2017 Source:Biochimica et Biophysica Acta (BBA) - Bioenergetics Author(s): Isabel Llorente-Garcia, Tchern Lenn, Heiko Erhardt, Oliver L. Harriman, Lu-Ning Liu, Alex Robson, Sheng-Wen Chiu, Sarah Matthews, Nicky J. Willis, Christopher D. Bray, Sang-Hyuk Lee, Jae Yen Shin, Carlos Bustamante, Jan Liphardt, Thorsten Friedrich, Conrad W. Mullineaux, Mark C. Leake (Source: Biochimica et Biophysica Acta (BBA) Bioenergetics)
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - November 24, 2017 Category: Biochemistry Source Type: research

Zinc deficiency as a mediator of toxic effects of alcohol abuse
ConclusionsGenerally, current findings suggest that assessment of Zn status could be used as a diagnostic marker of metabolic disturbances in alcohol abuse, whereas modulation of Zn metabolism may be a potential tool in the treatment of alcohol-associated disorders. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - November 24, 2017 Category: Nutrition Source Type: research

Relationship between degree of obstruction and airflow limitation in subglottic stenosis
ConclusionOur computer simulations suggest that the degree of airflow limitation in SGS patients may be estimated based on anatomic measurements alone. Future studies are recommended to test these predictions in larger cohorts. Level of Evidence4. Laryngoscope, 2017 (Source: The Laryngoscope)
Source: The Laryngoscope - November 24, 2017 Category: ENT & OMF Authors: Emily L. Lin, Jonathan M. Bock, Carlton J. Zdanski, Julia S. Kimbell, Guilherme J. M. Garcia Tags: Broncho ‐Esophagology Source Type: research

Investigation of the presence of HPV on KTP laser fibers following KTP laser treatment of papilloma
ConclusionHuman papillomavirus was undetectable by PCR on KTP laser fibers that were sterilized or unsterilized after use. Further studies are needed utilizing a transmission model to determine if HPV can be incubated from this fiber after sterilization. Level of EvidenceNA. Laryngoscope, 2017 (Source: The Laryngoscope)
Source: The Laryngoscope - November 24, 2017 Category: ENT & OMF Authors: Sonam Dodhia, Peter C. Baxter, Fei Ye, Michael J. Pitman Tags: Laryngology Source Type: research

Smoke-Free Policies in the World's 50 Busiest Airports - August 2017.
Abstract Exposure to secondhand smoke from burning tobacco products causes premature death and disease, including coronary heart disease, stroke, and lung cancer among nonsmoking adults and sudden infant death syndrome, acute respiratory infections, middle ear disease, exacerbated asthma, respiratory symptoms, and decreased lung function in children (1,2). The U.S. Surgeon General has concluded that there is no risk-free level of exposure to secondhand smoke (1). Previous CDC reports on airport smoke-free policies found that most large-hub airports in the United States prohibit smoking (3); however, the extent of ...
Source: MMWR Morb Mortal Wkl... - November 24, 2017 Category: Epidemiology Authors: Tynan MA, Reimels E, Tucker J, King BA Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Evaluation of Francisella tularensis δpdpC as a candidate live attenuated vaccine against respiratory challenge of Tularemia in C57BL/6J mouse model
ABSTRACT Francisella tularensis, which causes tularemia, is an intracellular and Gram‐negative bacterium. F. tularensis has received significant attention in recent decades because of their history as biological weapons. Thus, the development of novel vaccines directed against tularemia has been an important goal. The attenuated F. tularensis strain δpdpC, in which the pathogenicity determinant protein C gene (pdpC) was disrupted by TargeTron mutagenesis, was investigated as a potential vaccine candidate for tularemia in the present study. C57BL/6J mice immunized subcutaneously with 1 × 106 colony‐forming u...
Source: Microbiology and Immunology - November 24, 2017 Category: Microbiology Authors: Deyu Tian, Akihiko Uda, Eun ‐sil Park, Akitoyo Hotta, Osamu Fujita, Akio Yamada, Kazuhiro Hirayama, Kozue Hotta, Yuuki Koyama, Mika Azaki, Shigeru Morikawa Tags: Original Article Source Type: research

Molecules, Vol. 22, Pages 2057: Simultaneous Determination of Multiple Classes of Hydrophilic and Lipophilic Components in Shuang-Huang-Lian Oral Liquid Formulations by UPLC-Triple Quadrupole Linear Ion Trap Mass Spectrometry
In this study, an accurate, rapid, and specific UPLC-MS/MS method was established for simultaneous quantification of 18 compounds from multiple classes in SHL oral liquid formulations. Chromatographic separation was performed on a HSS T3 (1.8 μm, 2.1 mm × 100 mm) column, using a gradient mobile phase system of 0.1% formic acid in acetonitrile and 0.1% formic acid in water at a flow rate of 0.2 mL·min−1; the run time was 23 min. The MS was operated in negative electrospray ionization (ESI−) for analysis of 18 compounds using multiple reaction monitoring (MRM) mode. UPLC-ESI−-MRM-MS/MS metho...
Source: Molecules - November 24, 2017 Category: Chemistry Authors: Jun Liang Hui-Min Sun Tian-Long Wang Tags: Article Source Type: research

The effect of forest fires in 2015 on patients with asthma in a respiratory clinic in singapore and comparison with a control group in 2016
(Source: Respirology)
Source: Respirology - November 24, 2017 Category: Respiratory Medicine Tags: APSR Poster Abstracts Source Type: research

Mortality from systemic erythematosus lupus in Brazil: evaluation of causes according to the government health database
Conclusions This study identified a need for greater control of risk factors for cardiovascular diseases and a better understanding of the pathogenesis of atherosclerosis in SLE. Infectious causes are still frequent, and management should be improved, especially in the early stages of the disease. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - November 24, 2017 Category: Rheumatology Source Type: research

Pancreas Transplantation: Advantages of a Retroperitoneal Graft Position
Conclusions Retroperitoneal graft placement appears feasible with easy access for dissection the vascular site; comfortable technical vascular reconstruction; and a decreased risk of intestinal obstruction by separation of the small bowel from the pancreas graft. (Source: Cirugia Espanola)
Source: Cirugia Espanola - November 24, 2017 Category: Surgery Source Type: research

Effectiveness and safety of cefpodoxime in upper respiratory tract infections in adult Egyptian population a report from the Egyptian STAR registry
Conclusions High cure rates for acute maxillary sinusitis and acute tonsilopharyngitis, and a favorable safety and tolerability profile were noted following treatment with cefpodoxime. Thus, cefpodoxime seems to be effective as empirical treatment in adult Egyptian patients with acute UTRIs. (Source: Egyptian Journal of Ear, Nose, Throat and Allied Sciences)
Source: Egyptian Journal of Ear, Nose, Throat and Allied Sciences - November 24, 2017 Category: ENT & OMF Source Type: research

[Improving the Accuracy Rate of Analgesics and Sedatives Administration in an Intensive Care Unit].
CONCLUSIONS: With appropriately scaled protocols of sedatives and analgesics administration, intensive care nurses may easily target the consistent and optimal assessment and provide pain relief prior to sedation, which will improve the quality of sedation and patient safety. PMID: 29164549 [PubMed - in process] (Source: Pain Physician)
Source: Pain Physician - November 23, 2017 Category: Anesthesiology Authors: Lai HC, Chen YH, Li YJ, Huang HM, Tseng CH, Chan MC Tags: Hu Li Za Zhi Source Type: research

Classification of Chronic Obstructive Pulmonary Disease (COPD) according to the new Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017: Comparison with GOLD 2011.
Authors: Marçôa R, Rodrigues DM, Dias M, Ladeira I, Vaz AP, Lima R, Guimarães M Abstract Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality worldwide. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) project has been working to improve awareness, prevention and management of this disease. The aim of this study is to evaluate how COPD patients are reclassified by the 2017 GOLD system (versus GOLD 2011), to calculate the level of agreement between these two classifications in allocation to categories and to compare the performance of each clas...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 23, 2017 Category: Respiratory Medicine Tags: COPD Source Type: research

Imbalance between Subpopulations of Regulatory T Cells in Patients with Acute Exacerbation of COPD.
Authors: Yang X, Huo B, Zhong X, Su W, Liu W, Li Y, He Z, Bai J Abstract Human regulatory T cells (Tregs) have been reported to be not significantly different in the peripheral blood of patients with chronic obstructive pulmonary disease (COPD) and healthy controls. Recent research has identified some new markers for Tregs and indicated that Tregs are composed of distinct subpopulations. The aim of the study was to describe the changing patterns of circulating Treg subpopulations in patients with acute exacerbation of COPD (AECOPD) and healthy controls, and to explore their potential roles in AECOPD pathogenesis. B...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 23, 2017 Category: Respiratory Medicine Tags: COPD Source Type: research

Effect of fetal and infant growth on respiratory symptoms in preterm ‐born children
ConclusionsOur study suggested that antenatal and postnatal growth rates are important for future respiratory health in preterm‐born children, and that their effects may be mediated by modifiable factors. Minimizing exposure to environmental pollutants, especially maternal tobacco smoking, may improve outcomes. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - November 23, 2017 Category: Respiratory Medicine Authors: John Lowe, Sarah J. Kotecha, William J. Watkins, Sailesh Kotecha Tags: ORIGINAL ARTICLE: NEONATAL LUNG DISEASE Source Type: research

Giant Pseudoaneurysm of the Left Atrium after Pneumonectomy
Respiration (Source: Respiration)
Source: Respiration - November 23, 2017 Category: Respiratory Medicine Source Type: research

Cystic Lung Disease in Genetic Syndromes with Deficient Tumor Suppressor Gene Function
Cystic lung diseases constitute a distinct group of rare lung disorders, among which two result from monogenic defects affecting tumor suppressor genes: lymphangioleiomyomatosis, either sporadic or associated with tuberous sclerosis complex, and Birt-Hogg-Dub é syndrome. These disorders have similarities in their clinical expression, including occurrence in young adults, multiple pulmonary cysts, recurrent pneumothorax, skin hamartomas, and renal tumors. However, they markedly differ in their gender distribution, pathogenesis, disease course, and progno sis. Our knowledge on these two rare conditions is rapidly expa...
Source: Respiration - November 23, 2017 Category: Respiratory Medicine Source Type: research

Decision ‐making in response to respiratory veno‐venous extracorporeal membrane oxygenation referrals: is current practice precise enough?
(Source: Anaesthesia)
Source: Anaesthesia - November 23, 2017 Category: Anesthesiology Authors: M. Charlesworth, A. D. Ashworth, J. M. Barker Tags: Editorial Source Type: research

Use of ceftolozane-tazobactam in a cystic fibrosis patient with multidrug-resistant pseudomonas infection and renal insufficiency.
We report the successful use of ceftolozane/tazobactam (C/T) to treat a pulmonary exacerbation in a 35 year old female, post lung transplant, with cystic fibrosis (CF), malnutrition, chronic kidney disease, and multi-drug resistant Pseudomonas aeruginosa infection (MDR PSA). Given the complexity of the clinical profile, we measured drug levels of C/T during treatment of her current exacerbation to determine pharmacokinetics. The patient achieved an estimated ceftolozane peak of 174.1 μg/mL and trough of 9.2 μg/mL. Serum half-life was found to be slightly shorter than previously reported in normal subjects, (2.3 hr. v...
Source: Respiratory Care - November 23, 2017 Category: Respiratory Medicine Authors: Stokem K, Zuckerman JB, Nicolau DP, Wungwattana M, Sears EH Tags: Respir Med Case Rep Source Type: research

Solitary fibrous tumor of the abdominal wall re-surfacing as unilateral pleural effusion and mass: A case report and review of the literature.
Conclusions: Solitary fibrous tumor are rare mesenchymal tumors that were initially described in the pleura, but have now been reported in many other sites. Complete surgical resection is the mainstay therapy for all cases; however, long-term monitoring and surveillance several years after initial presentation is crucial to prevent disease recurrence, and adjuvant treatment may be necessary for patients with high-risk features. Additional studies are needed to demonstrate the clinical utility of risk stratification models and to develop post-treatment surveillance guidelines for extrathoracic SFTs. PMID: 29159031 [Pub...
Source: Respiratory Care - November 23, 2017 Category: Respiratory Medicine Authors: Bi X, Zhai J, Chun CD Tags: Respir Med Case Rep Source Type: research

Successful treatment of postoperative massive pulmonary embolism with paradoxal arterial embolism through extracorporeal life support and thrombolysis.
Abstract Pulmonary embolism is a common clinical entity related to high mortality. About 200,000 to 300,000 patients die every year due to pulmonary embolism. The purpose of this article is to describe a case of a patient who on the second postoperative day after undergoing thromboembolectomy of the left femoral artery, manifested a massive pulmonary embolism. Due to cardiorespiratory collapse a combined treatment via extracorporeal life support (ECLS) and parallel catheter thrombolysis was decided and performed. By cardiorespiratory improvement and final stabilization the patient was successfully weaned from ECLS...
Source: Respiratory Care - November 23, 2017 Category: Respiratory Medicine Authors: Grapatsas K, Leivaditis V, Zarogoulidis P, Tsilogianni Z, Kotoulas S, Kotoulas C, Koletsis E, Iliadis IS, Spiliotopoulos K, Trakada G, Veletza L, Kallianos A, Tsiouda T, Kosmidis C, Hohenforst-Schmidt W, Huang H, Haussmann R, Haussmann E, Dahm M Tags: Respir Med Case Rep Source Type: research

Is It Necessary to Heat and Humidify Respiratory Gases for Resuscitation in Preterm Infants?
In this volume of The Journal, McGrory et  al report the results of a well-designed multicenter randomized controlled trial designed to determine whether the use of heated and humidified gases for respiratory support during the stabilization and transport of infants (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - November 23, 2017 Category: Pediatrics Authors: Waldemar A. Carlo, Robert L. Chatburn Tags: Editorials Source Type: research

Differential Expression of Ion Channels in Adult and Neonatal Rat Ventral Respiratory Column
AbstractIn mammals, the neural control of breathing is attributed to circuits distributed along the ventral respiratory column (VRC) in the ventrolateral medulla. The VRC contains the kernel for generation of the inspiratory phase of respiratory rhythm and nuclei involved in central chemoreception. During development, the respiratory rhythm, as well as central chemosensitivity, adjusts to meet the changing physiological requirements associated with increased body weight and size. Gene expression in VRC ontogeny is well characterized. However, little is known about gene expression in the VRC during postnatal development. He...
Source: Journal of Molecular Neuroscience - November 23, 2017 Category: Neuroscience Source Type: research

Physical activity and activity space in patients with pulmonary fibrosis not prescribed supplemental oxygen
Patients with pulmonary fibrosis (PF) have impaired quality of life, and research suggests that dyspnea and physical activity are primary drivers. As PF progresses, some patients notice the disease “shrinks th... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - November 23, 2017 Category: Respiratory Medicine Authors: Elisabeth Dowling Root, Bridget Graney, Susan Baird, Tara Churney, Kailtin Fier, Majorie Korn, Mark McCormic, David Sprunger, Tomas Vierzba, Frederick S. Wamboldt and Jeffery J. Swigris Tags: Research article Source Type: research

Physician perspectives on the burden and management of asthma in six countries: The Global Asthma Physician Survey (GAPS)
Despite recognition of asthma as a growing global issue and development of global guidelines, asthma treatment practices vary between countries. Several studies have reported patients ’ perspectives on asthma c... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - November 23, 2017 Category: Respiratory Medicine Authors: Kenneth R. Chapman, David Hinds, Peter Piazza, Chantal Raherison, Michael Gibbs, Timm Greulich, Kenneth Gaalswyk, Jiangtao Lin, Mitsuru Adachi and Kourtney J. Davis Tags: Research article Source Type: research

This abstract has been moved to APL017
(Source: Respirology)
Source: Respirology - November 23, 2017 Category: Respiratory Medicine Tags: Clinical Respiratory Medicine 1 Source Type: research

A rare presentation of bronchogenic cyst with atrial fibrilation
(Source: Respirology)
Source: Respirology - November 23, 2017 Category: Respiratory Medicine Tags: Clinical Respiratory Medicine 1 Source Type: research

A familial case of birt ‐hogg‐dube syndrome (bhds) complicated with bladder cancer and lung cancera case report and literature review
(Source: Respirology)
Source: Respirology - November 23, 2017 Category: Respiratory Medicine Tags: Clinical Respiratory Medicine 1 Source Type: research