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Editorial Board
(Source: Tuberculosis)
Source: Tuberculosis - October 17, 2017 Category: Respiratory Medicine Source Type: research

Organ Dysfunction and Failure Following Brain Death Do Not Preclude Successful Donation
ConclusionCurrent measures of organ failure and dysfunction do not predict the success of organ donation. Successful donor management in the face of severe organ dysfunction and failure can result in lives saved. (Source: World Journal of Surgery)
Source: World Journal of Surgery - October 17, 2017 Category: Surgery Source Type: research

Plasma Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome: A Multicenter Survival and Longitudinal Prospective Observation Study: Erratum
No abstract available (Source: Shock)
Source: Shock - October 17, 2017 Category: Emergency Medicine Tags: Erratum Source Type: research

Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice
Conclusions: These results suggest that strain-specific changes in chromatin and transcription in response to chemical exposure lead to a “compensation” for underlying genetic-driven interindividual differences in the baseline chromatin and transcriptional state. This work represents an example of how chemical and environmental exposures can be evaluated to better understand gene-by-environment interactions, and it demonstrates the important role of chromatin response in transcriptomic changes and, potentially, in deleterious effects of exposure. https://doi.org/10.1289/EHP1937 Received: 21 March 2017 Revis...
Source: EHP Research - October 17, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

The Differences in Spirometry Predictive Equations in Classifying Presence and Degree of Lung Function Impairment: Which Suit Fits the Best?
AbstractPurposeThe aim of this study was to compare the differences between three most commonly used predictive equations (PE): ECCS (European Community of Coal and Steel), the third National Health and Nutrition Examination Survey (NHANES III), and GLI (Global Lung Initiative) in healthy individuals and when grading severity of lung function impairment in patients with obstructive lung diseases.MethodsThe study included 200 healthy volunteers and 200 patients with obstructive lung diseases at the Institute for Pulmonary Diseases of Vojvodina. In all subjects, we calculated the absolute and relative (percent) predicted val...
Source: Lung - October 17, 2017 Category: Respiratory Medicine Source Type: research

What every intensivist should know about acute respiratory distress syndrome and diffuse alveolar damage
RESUMO A s índrome do desconforto respiratório agudo é um desafio para o intensivista. A característica principal desta doença aguda é o dano alveolar difuso, presente em cerca de metade dos pacientes com a síndrome. É claro que o suporte respiratório à síndrome do desconforto respiratório agudo te m melhorado gradualmente nas últimas décadas. É também evidente que todos estes procedimentos são benéficos, já que reduzem a lesão pulmonar e mantêm o paciente vivo. Isto deve ser int...
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

Extracorporeal membrane oxygenation in acute respiratory distress syndrome due to influenza A (H1N1)pdm09 pneumonia. A single-center experience during the 2013-2014 season
Conclusion: The survivors were relatively young and discharged with good functional status (i.e., enhancing quality-adjusted life-years-saved). Our experience shows that even a relatively new extracorporeal membrane oxygenation program can play an important role in that capacity and provide excellent outcomes for the sickest patients. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - October 16, 2017 Category: Intensive Care Source Type: research

The patient with a complex chronic respiratory disease: a specialist of his own life?
Authors: Houben-Wilke S, Augustin IM, Wouters BB, Stevens R, Janssen DJA, Spruit MA, Vanfleteren LE, Franssen FM, Wouters EF Abstract INTRODUCTION: The independent and central role of the patient with a complex chronic respiratory disease in targeted, personalized disease management strategies is becoming increasingly important. Patients are the ones living with the disease and are finally responsible for their lives underlining their role as essential members of the interdisciplinary treatment team. Areas covered: The present paper narratively reviews existing research and discusses the special, as well as special...
Source: Expert Review of Respiratory Medicine - October 16, 2017 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Interprofessional Pulmocheck care pathway: An innovative approach to managing pediatric asthma care in the Netherlands.
CONCLUSIONS: The specialty pediatric asthma care pathway revealed a high number of children with newly diagnosed asthma, but was also helpful to exclude this diagnosis. However, the referral rate of GPs to this pathway was low, but in the children, that were referred several changes in the clinical management were advised and the frequency of monitoring of the children with diagnosed asthma was not in accordance with the asthma guidelines. PMID: 29028376 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - October 16, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

A computable phenotype for asthma case identification in adult and pediatric patients: External validation in The Chicago Area Patient-Outcomes Research Network (CAPriCORN).
CONCLUSIONS: The excellent positive and negative predictive values in this multi-center external validation study establish a useful tool to identify asthma cases in in the electronic health record for research and care. This computable phenotype could be used in large-scale comparative-effectiveness trials. PMID: 29027824 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - October 16, 2017 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Issue Information
(Source: Respirology Case Reports)
Source: Respirology Case Reports - October 16, 2017 Category: Respiratory Medicine Tags: Issue Information Source Type: research

Perioperative pain management in cardiac surgery: a systematic review.
CONCLUSIONS: Over the past 17 years, opioids are still the most extensively used therapy, whereas we found only few trials investigating other drugs (e.g. paracetamol). Regional anesthesia techniques, especially thoracic epidural analgesia and intrathecal morphine administration, can effectively treat pain, but have not yet showed any significant impact on major clinical outcomes, with several concern related to their potential complications. To date multimodal analgesia with implementation of regional analgesia seems to be the best choice. In the future, better-designed studies should consider other drugs stratifying grou...
Source: Minerva Anestesiologica - October 16, 2017 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Use of a Remote Inhaler Monitoring Device to Measure Change in Inhaler Use with Chronic Obstructive Pulmonary Disease Exacerbations
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - October 16, 2017 Category: Respiratory Medicine Authors: Kaharu Sumino Emily R. Locke Sheryl Magzamen Ina Gylys-Colwell Olivier Humblet Huong Q. Nguyen Rachel M. Thomas Vincent S. Fan Source Type: research

Hybrid Lipid/Polymer Nanoparticles for Pulmonary Delivery of siRNA: Development and Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - October 16, 2017 Category: Respiratory Medicine Authors: Ivana d'Angelo Gabriella Costabile Estelle Durantie Paola Brocca Valeria Rondelli Annapina Russo Giulia Russo Agnese Miro Fabiana Quaglia Alke Petri-Fink Barbara Rothen-Rutishauser Francesca Ungaro Source Type: research

Homogeneity of Aerosol Deposition and Mucociliary Clearance are Improved Following Ivacaftor Treatment in Cystic Fibrosis
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - October 16, 2017 Category: Respiratory Medicine Authors: William D. Bennett Kirby L. Zeman Beth L. Laube Jihong Wu Gail Sharpless Peter J. Mogayzel Scott H. Donaldson Source Type: research

May Dietary Supplementation Augment Respiratory Burst in Wound-Site Inflammatory Cells?
Antioxidants& Redox Signaling , Vol. 0, No. 0. (Source: Antioxidants and Redox Signaling)
Source: Antioxidants and Redox Signaling - October 16, 2017 Category: Research Authors: Amitava Das Ryan Dickerson Piya Das Ghatak Gayle M. Gordillo Scott Chaffee Abhijoy Saha Savita Khanna Sashwati Roy Source Type: research

Positive end-expiratory pressure adjusted for intra-abdominal pressure – A pilot study
Intra-abdominal hypertension (IAH) is associated with impaired respiratory function. Animal data suggest that positive end-expiratory pressure (PEEP) levels adjusted to intra-abdominal pressure (IAP) levels may counteract IAH-induced respiratory dysfunction.In this pilot study, our aims were to assess whether PEEP adjusted for IAP can be applied safely in patients with IAH. (Source: Journal of Critical Care)
Source: Journal of Critical Care - October 16, 2017 Category: Intensive Care Authors: Adrian Regli, Bart Leon De Keulenaer, Annamaria Palermo, Peter Vernon van Heerden Source Type: research

Preoperative Progressive Pneumoperitoneum in Obese Patients With Loss of Domain Hernias
Repair of hernias with loss of domain in obese patients can lead to acute respiratory failure. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 16, 2017 Category: Surgery Authors: A.C. Valezi, B.G.F. Melo, M. Liberatti, A.C. Marson, A.G. Lopes Tags: Paired papers Source Type: research

Firing a loaded gun during sleep in an elderly man with a “perfect storm” of risk factors including severe obstructive sleep apnea
ConclusionsIn this case, there was a “perfect storm” of sleep and psychological risk factors that converged to strongly promote precipitous arousals with sleep-related violence in a patient with documented sleep motor dyscontrol. Primary care physicians, including geriatric specialists, should question patients and their spouses ab out any symptoms of sleep disorders. (Source: Sleep and Breathing)
Source: Sleep and Breathing - October 16, 2017 Category: Respiratory Medicine Source Type: research

Sleep disorders and health-related quality of life in patients with interstitial lung disease
ConclusionsIn this sample of patients with IPF and sarcoidosis, obstructive sleep apnea is common at least in a mild degree of severity. The SF-36 questionnaire may be a useful tool for the evaluation of the quality of life in these patients. (Source: Sleep and Breathing)
Source: Sleep and Breathing - October 16, 2017 Category: Respiratory Medicine Source Type: research

Adult case of acute flaccid paralysis with enterovirus D68 detected in the CSF
We report a 28-year-old Japanese woman admitted to our hospital with distal muscular weakness after experiencing upper respiratory symptoms and subsequently diagnosed with AFP. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - October 16, 2017 Category: Neurology Authors: Kimura, K., Fukushima, T., Katada, N., Shimizu, H., Nakamura, T., Fujimoto, T., Hanaoka, N., Tanaka-Taya, K., Makino, K. Tags: MRI, All Infections, All Clinical Neurology, Viral infections, Spinal cord infarction Case Source Type: research

High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis
ConclusionsIn patients with acute hypoxemic respiratory failure HFNC was not associated with a difference in mortality compared to NIV or standard oxygen. Secondary outcomes including dyspnea, tolerance, and safety were not systematically reported. Residual heterogeneity and variable reporting of secondary outcomes limit the conclusions that can be made in this review. Prospective trials designed to evaluate the efficacy and safety of HFNC in patients with acute hypoxemic respiratory failure are required. (Source: Systematic Reviews)
Source: Systematic Reviews - October 16, 2017 Category: International Medicine & Public Health Source Type: research

Home supply of emergency oral steroids and reduction in asthma healthcare utilization
Abstract ObjectiveTo determine if children with moderate‐to‐severe persistent asthma have decreased healthcare utilization after receiving a prescription and instructions to use an at home emergency supply of oral steroids during asthma exacerbations. MethodsA quasi‐experimental design study with a historical control from retrospective chart review was performed for patients aged 2‐18 years seen in a tertiary care pediatric pulmonary clinic for moderate to severe persistent asthma. Baseline utilization of the emergency department, inpatient hospital, and pediatric intensive care unit for asthma exacerbations was co...
Source: Pediatric Pulmonology - October 16, 2017 Category: Respiratory Medicine Authors: Lisa M. Sarzynski, Tiffany Turner, David R. Stukus, Elizabeth Allen Tags: ORIGINAL ARTICLE: ASTHMA Source Type: research

Levels of exhaled carbon monoxide measured during an intervention program predict 1-year smoking cessation: a retrospective observational cohort study
npj Primary Care Respiratory Medicine, Published online: 16 October 2017; doi:10.1038/s41533-017-0060-8 (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - October 16, 2017 Category: Primary Care Authors: Huei-Guan Shie Sheng-Wei Pan Wen-Kuang Yu Wei-Chih Chen Li-Ing Ho Hsin-Kuo Ko Source Type: research

The Fortuitous Discovery of the Olin EILOBI Breathing Techniques: A Case Study
Exercise-induced laryngeal obstruction (EILO) is the term for the condition previously named vocal cord dysfunction and paradoxical vocal fold motion. It is defined by glottic or supraglottic obstruction during periods of intense exercise. Not all patients respond to conventional therapy with speech-language pathology, behavioral health interventions, and treatment of contributing conditions. In this edition of Journal of Voice, the authors describe a novel series of respiratory retraining techniques, now called Olin EILOBI (EILO biphasic inspiratory) breathing techniques, specifically designed for athletes with EILO. (Sou...
Source: Journal of Voice - October 16, 2017 Category: ENT & OMF Authors: Sarah Graham, Emily Deardorff, Kristina Johnston, J. Tod Olin Source Type: research

Choanal Atresia: Birth Without Breath
AbstractBilateral Choanal atresia is a medical emergency. Corrective surgery is the mainstay of the treatment. Hegar ’s dilator was used in all cases to break the bony/membranous atretic plate. The 22 cases of choanal atresia all operated by the first author were included in this study. Eight cases were 1–5 year old with bilateral choanal atresia and all required immediate surgery as they had repeated attacks of respiratory distress and cycle of cyanosis. Eight cases were of CHARGE Syndrome. All the cases were operated under general anaesthesia. Hegar’s dilators were used and nasal stents were placed...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - October 16, 2017 Category: ENT & OMF Source Type: research

Role of serum albumin as a nanoparticulate carrier for nose ‐to‐brain delivery of R‐flurbiprofen: implications for the treatment of Alzheimer's disease
ConclusionsSerum albumin‐based nanoparticles administered via the nasal route may be a viable approach in delivering therapeutic agents to the brain to alleviate mitochondrial dysfunction in AD. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - October 16, 2017 Category: Drugs & Pharmacology Authors: Ling Rong Wong, Paul C. Ho Tags: Research Paper Source Type: research

The Olin EILOBI Breathing Techniques: Description and Initial Case Series of Novel Respiratory Retraining Strategies for Athletes with Exercise-Induced Laryngeal Obstruction
Exercise-induced laryngeal obstruction (EILO), the condition previously known as paradoxical vocal fold motion and vocal cord dysfunction, is characterized by inappropriate glottic or supraglottic obstruction during high-intensity exercise, causing exertional dyspnea, frequently with stridor. EILO is definitively diagnosed through upper-airway visualization during a characteristic episode. Although respiratory retraining is a primary therapy for EILO, many patients report symptom persistence despite adequate performance of traditional techniques. (Source: Journal of Voice)
Source: Journal of Voice - October 16, 2017 Category: ENT & OMF Authors: Kristina L. Johnston, Hannah Bradford, Heather Hodges, Camille M. Moore, Emily Nauman, J. Tod Olin Source Type: research

Pulmonary schistosomiasis mimicking IgG4 ‐related lung disease
IgG4‐related disease (IgG4‐RD) is a systemic fibroinflammatory disease characterized by tumefactive lesions in various organ systems, including the lungs. Clinical and radiological manifestations of IgG4‐RD are relatively non‐specific, and we report a case highlighting the importance of histopathological confirmation in cases of suspected IgG4‐related lung disease. A 44‐year‐old male with significantly elevated serum IgG4 levels, patchy consolidation on thoracic CT imaging, and cough was referred with suspected IgG4‐related lung disease. However, surgical lung biopsy revealed an unexpected diagnosis of pulm...
Source: Respirology Case Reports - October 16, 2017 Category: Respiratory Medicine Authors: Timothy Baird, Caroline L Cooper, Richard Wong, Naomi Runnegar, Gregory Keir Tags: Case Report Source Type: research

Muscle specific differences in expression and phosphorylation of the Janus kinase 2/ Signal Transducer and Activator of Transcription 3 following long ‐term mechanical ventilation and immobilization in rats
ConclusionThe JAK2/STAT3 pathway was differentially activated in plantaris, intercostal, and diaphragm muscles in response to the ICU condition. Thus, JAK2/STAT3 inhibitors may provide an attractive pharmacological intervention strategy in immobilized ICU patients, but further experimental studies are required in the study of muscle‐specific effects on muscle mass and function in response to both short‐ and long‐term exposure to the ICU condition prior to the translation into clinical research and practice.This article is protected by copyright. All rights reserved. (Source: Acta Physiologica)
Source: Acta Physiologica - October 15, 2017 Category: Physiology Authors: Heba Salah, Wen Fury, Jesper Gromada, Yu Bai, Tamar Tchkonia, James L. Kirkland, Lars Larsson Tags: Regular Paper Source Type: research

Recognizing Workplace Factors Contributing to Interstitial Lung Disease.
PMID: 29028374 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2017 Category: Respiratory Medicine Authors: Harber P Tags: Am J Respir Crit Care Med Source Type: research

Health Disparities in Patients with Pulmonary Arterial Hypertension: A Blueprint for Action. An Official American Thoracic Society Statement.
CONCLUSIONS: At present, there are few studies that address health disparities in PAH. Given the potential adverse impact of health disparities, we recommend that research efforts be undertaken to address the topics discussed in the document. Awareness of health disparities will likely improve advocacy efforts, public health policy and the quality of care of vulnerable populations with PAH. PMID: 29028375 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2017 Category: Respiratory Medicine Authors: Talwar A, Garcia JGN, Tsai H, Moreno M, Lahm T, Zamanian RT, Machado R, Kawut SM, Selej M, Mathai S, D'Anna LH, Sahni S, Rodriquez EJ, Channick R, Fagan K, Gray M, Armstrong J, Rodriguez Lopez J, de Jesus Perez V, Pulmonary Circulation Assembly Tags: Am J Respir Crit Care Med Source Type: research

Pulmonary Hypertension in Children.
Authors: PMID: 29028373 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2017 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

A Model ‐Based Cluster Analysis of Maternal Emotion Regulation and Relations to Parenting Behavior
In a diverse community sample of mothers (N = 108) and their preschool‐aged children (Mage = 3.50 years), this study conducted person‐oriented analyses of maternal emotion regulation (ER) based on a multimethod assessment incorporating physiological, observational, and self‐report indicators. A model‐based cluster analysis was applied to five indicators of maternal ER: maternal self‐report, observed negative affect in a parent–child interaction, baseline respiratory sinus arrhythmia (RSA), and RSA suppression across two laboratory tasks. Model‐based cluster analyses revealed four ...
Source: Family Process - October 15, 2017 Category: International Medicine & Public Health Authors: Anne Shaffer, Monica Whitehead, Molly Davis, Diana Morelen, Cynthia Suveg Tags: Original Article Source Type: research

Effect of simulation-based sedation training course for dentists on emergency response monitoring
In 1993, American Society of Anesthesiologists published ‘Practice Guidelines for Sedation and Analgesia by Non-Anesthesiologists (ASA-SED)’ and it was updated in 2002 [1]. This guideline indicates recommendations and cautions for non-anesthesiologists including dentists to perform effective and safe sedation and analgesia. High quality and safety sed ation needs not only adequate emergency equipment buy also appropriate respiratory monitoring for emergency response. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - October 15, 2017 Category: Emergency Medicine Authors: Masanori Haba, Nobuyasu Komasawa, Takuro Sanuki, Kazuaki Atagi Source Type: research

Respiratory comorbidity in South African children with atopic dermatitis.
CONCLUSIONS: In this cohort of SA children with moderate to severe AD, comorbidity with respiratory allergies was high. The prevalence of respiratory allergies increased with age while food allergy decreased with age, in keeping with the pattern of the allergic march. Seasonal allergies increased with age, while house-dust mite and pet allergy peaked in younger children, in keeping with early exposure via a defective skin barrier. Early and effective restoration of the skin barrier in AD may be a target for reducing aeroallergen-related diseases. PMID: 29022537 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - October 14, 2017 Category: African Health Tags: S Afr Med J Source Type: research

HIV-positive patients in the intensive care unit: A retrospective audit.
CONCLUSIONS: Respiratory illnesses remain the main indication for ICU in HIV-positive patients. HIV infection is often diagnosed late, with patients presenting with life-threatening illnesses. Severity of illness as indicated by a high APACHE ΙΙ score, multiple organ dysfunction requiring inotropic support and RRT, rather than receipt of HAART, CD4 count and diagnosis at ICU admission, are predictors of ICU and hospital mortality. PMID: 29022532 [PubMed - in process] (Source: South African Medical Journal)
Source: South African Medical Journal - October 14, 2017 Category: African Health Tags: S Afr Med J Source Type: research

Basic and Advanced EMS Providers Are Equally Effective in Naloxone Administration for Opioid Overdose in Northern New England.
This study compares the effectiveness and appropriateness of naloxone administration between BLS and ALS providers. METHODS: All Vermont, New Hampshire, and Maine EMS patient encounters between April 1, 2014 and December 31, 2016 where naloxone was administered were examined and 3,219 patients were identified. The proportion of successful reversals of opioid overdose, based on improvement in the Glasgow Coma Scale (GCS), respiratory rate (RR), and provider global assessment (GA) of response to medication was compared between BLS and ALS providers using a Chi-Squared statistic, Fisher's exact or Wilcoxon rank-sum test. ...
Source: Prehospital Emergency Care - October 14, 2017 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

GSE104941 Identification of candidate genes associated with breast muscle of broilers exposed to atmospheric ammonia using RNA sequencing
In this study, high concentrations of atmospheric ammonia were found to lower slaughter rate and broiler breast meat yield significantly (P
Source: GEO: Gene Expression Omnibus - October 14, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Gallus gallus Source Type: research

A Case of Tocilizumab-resistant TAFRO Syndrome Complicated by Type II Respiratory Failure.
Authors: Aoki T, Wada M, Kawashima A, Hirakawa K, Nagata A, Kagawa K Abstract A 66-year-old man with a several year history of thrombocytopenia, pleural effusion and ascites, anasarca, and organomegaly presented with general fatigue, appetite loss, dyspnea with type II respiratory failure. The precise history of the patient and the re-evaluation of lymph node and bone marrow biopsies conducted by the previous physician indicated TAFRO syndrome. The patient's laboratory data improved for a year with tocilizumab, but then worsened to the point that the patient required artificial ventilation due to the deterioration ...
Source: Internal Medicine - October 14, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

A Case of Sudden Respiratory Failure due to Tracheobronchomalacia by Relapsing Polychondritis, Successfully Rescued by Multiple Metallic Stenting and Tracheostomy.
Authors: Oryoji D, Ono N, Himeji D, Yoshihiro K, Kai Y, Matsuda M, Tsukamoto H, Ueda A Abstract Relapsing polychondritis (RP) is a rare systemic autoimmune disease that affects cartilaginous structures. RP causes tracheobronchomalacia (TBM) by affecting the bronchial cartilage. TBM is a fatal condition characterized by excessive weakening of the walls of the trachea and bronchi. We herein report a case of a 73-year-old man who experienced sudden respiratory failure due to TBM caused by RP. Immunosuppressive treatment did not improve his respiratory failure. Multiple metallic stentings dramatically improved his seve...
Source: Internal Medicine - October 14, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Impaired chemosensory control of breathing after depletion of bulbospinal catecholaminergic neurons in rats.
Abstract Bulbospinal catecholaminergic neurons located in the rostral aspect of the ventrolateral medulla (C1 neurons) or within the ventrolateral pons (A5 neurons) are involved in the regulation of blood pressure and sympathetic outflow. A stimulus that commonly activates the C1 or A5 neurons is hypoxia, which is also involved in breathing activation. Although pharmacological and optogenetic evidence suggests that catecholaminergic neurons also regulate breathing, a specific contribution of the bulbospinal neurons to respiratory control has not been demonstrated. Therefore, in the present study, we evaluated whet...
Source: Pflugers Archiv : European Journal of Physiology - October 14, 2017 Category: Physiology Authors: Malheiros-Lima MR, Totola LT, Takakura AC, Moreira TS Tags: Pflugers Arch Source Type: research

Correlation of serum vascular adhesion protein-1 with airflow limitation and quality of life in stable chronic obstructive pulmonary disease
The serum vascular adhesion protein-1 (VAP-1) level increases in chronic inflammatory diseases. The present study aimed to examine serum VAP-1 level in patients with stable chronic obstructive pulmonary disease (COPD) and the correlation of this marker with airflow limitation and health-related quality of life using the COPD Assessment Test (CAT). (Source: Respiratory Medicine)
Source: Respiratory Medicine - October 14, 2017 Category: Respiratory Medicine Authors: Mojtaba Amani, Naiemeh Ghadimi, Mohammad Reza Aslani, Hassan Ghobadi Source Type: research

Antibiotic exposure and interpersonal variance mask the effect of ivacaftor on respiratory microbiota composition
G551D is a class III mutation of the cystic fibrosis transmembrane regulator (CFTR) that results in impaired chloride channel function in cystic fibrosis (CF). Ivacaftor, a CFTR-potentiating agent improves sweat chloride, weight, lung function, and pulmonary exacerbation rate in CF patients with G551D mutations, but its effect on the airway microbiome remains poorly characterised. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - October 14, 2017 Category: Respiratory Medicine Authors: Anton Y. Peleg, Jocelyn Choo, Katherine Langan, Deirdre Edgeworth, Dominic Keating, John Wilson, Geraint B. Rogers, Tom Kotsimbos Tags: Original Article Source Type: research

Does vitamin E prevent asthma or wheeze in children: a systematic review and meta-analysis
Asthma is a heterogeneous disease with multiple phenotypes. Epidemiologic studies suggest a close relationship between vitamin E and the occurrence of asthma, wheezing and atopic conditions during childhood. Previous results on its effects have been conflicting. The aim of this meta-analysis was to critically examine the current evidence on the association of vitamin E with childhood asthma and wheezing. We searched electronic databases for observational studies in English-language journals published from 2000 to 2016. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - October 14, 2017 Category: Respiratory Medicine Authors: Wu Hui, Chunwei Zhang, Yongqing Wang, Yanlin Li Tags: Review Source Type: research

Structural insights of a self-assembling 9-residue peptide from the C-terminal tail of the SARS corona virus E-protein in DPC and SDS micelles: A combined high and low resolution spectroscopic study
In this study, we have characterized the mechanism of membrane interaction of a short, 9-residue peptide TK9 (T55VYVYSRVK63) that had been derived from the carboxyl terminal of the Severe Acute Respiratory Syndrome (SARS) Corona virus (SARS CoV) Envelope (E) protein. The peptide has been studied for its physical changes in the presence of both zwitterionic DPC and negatively charged SDS model membrane micelles, respectively, with the help of a battery of biophysical techniques including two-dimensional solution state NMR spectroscopy. Interestingly, in both micelle environments, TK9 adopted an alpha helical conformation; h...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - October 14, 2017 Category: Biochemistry Source Type: research

Molecules, Vol. 22, Pages 1726: Caustic Ingestion in the Elderly: Influence of Age on Clinical Outcome
lena Kuzelova Caustic poisonings are still associated with many fatalities. Studies focusing on the elderly are rare. The purpose of the present study was to compare the clinical outcomes of caustic ingestion injury in elderly and non-elderly adults with regard to gender, intent of exposure, substance ingested, severity of mucosal injury, complications, and mortality. Caustic substance exposures reported to the National Toxicological Information Centre in Slovakia during 1998–2015 were reviewed retrospectively. The patients were divided into two groups: the non-elderly (<60 years) and elderly adults (&...
Source: Molecules - October 14, 2017 Category: Chemistry Authors: Blazena Caganova Tatiana Foltanova Erik Puchon Elena Ondriasova Silvia Plackova Tomas Fazekas Magdalena Kuzelova Tags: Article Source Type: research

The leukotriene receptor antagonist pranlukast attenuates airway remodeling by suppressing TGF- β signaling
Conclusions The leukotriene receptor antagonist pranlukast can reduce airway inflammation and remodeling by inhibiting TGF-β/Smad signaling in an OVA-sensitized and -challenged asthma mouse model, thus suppressing AHR. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - October 14, 2017 Category: Respiratory Medicine Source Type: research

Prevalence of urinary tract infections mimicking respiratory infections and risk factors associated
. (Source: Infectious Diseases)
Source: Infectious Diseases - October 14, 2017 Category: Infectious Diseases Authors: Kalid Bouaghroum Pierre-Luc Genillier Dominique Neri Djamel Lameche Matteo Vassallo Source Type: research

PufQ regulates porphyrin flux at the haem/bacteriochlorophyll branchpoint of tetrapyrrole biosynthesis via interactions with ferrochelatase
This article is protected by copyright. All rights reserved. The switch from aerobic to photosynthetic growth in the purple photosynthetic bacterium Rhodobacter sphaeroides is based on oxygen availability. Here we demonstrate that the pufQ gene product regulates this switch via interactions with ferrochelatase, which drives porphyrin flux towards bacteriochlorophyll rather than haem. The co‐location of pufQ and photosystem genes in the pufQBALMX operon ensures that switching tetrapyrrole metabolism towards bacteriochlorophyll is coordinated with the production of reaction centre and light harvesting polypeptides. (Sourc...
Source: Molecular Microbiology - October 14, 2017 Category: Microbiology Authors: Jack W. Chidgey, Philip J. Jackson, Mark J. Dickman, C. Neil Hunter Tags: Research Article Source Type: research