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Plague
What is plague? Plague is an infectious disease found in some small mammals and their fleas. People can contract plague if they are in bitten by infected fleas, and develop the bubonic form of plague. Sometimes bubonic plague progresses to pneumonic plague, when the bacteria reaches the lungs. Person-to-person transmission is possible through the inhalation of infected respiratory droplets of a person who has pneumonic plague. Common antibiotics are efficient to cure plague, if they are delivered very early, because the course of the disease is usually rapid. (Source: WHO Feature Stories)
Source: WHO Feature Stories - October 23, 2017 Category: International Medicine & Public Health Tags: plague [subject], bubonic plague, pneumonic plague, Q & A [doctype] Source Type: news

Virus-like particle vaccine protects against RSV vaccine-enhanced respiratory disease, study finds
(Georgia State University) Researchers have discovered that a virus-like particle vaccine can prime the body's immune response and prevent the severe respiratory disease that results when patients given an early form of a vaccine for respiratory syncytial virus (RSV) are exposed to RSV, according to a study led by Georgia State University. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 23, 2017 Category: Infectious Diseases Source Type: news

What is Usher Syndrome?
Discussion Over 7000 diseases are considered rare disorders according to the National Organization for Rare Disorders® (NORD, rarediseases.org). NORD is a patient advocacy organization dedicated to individuals with rare diseases and the organizations that serve them. They have information on about 1200 rare diseases on their website (https://rarediseases.org/for-patients-and-families/information-resources/rare-disease-information/). Hearing loss (HL) is not rare and is a common problem across the ages. It affects 360 million people worldwide which is about 5% of the population. There are many causes of hearing loss an...
Source: PediatricEducation.org - October 23, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Health Concerns Remain in Aftermath of California Wildfires
(MedPage Today) -- Cleanup poses new respiratory risks (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - October 22, 2017 Category: Psychiatry Source Type: news

Notes from the field: Counterfeit percocet-related overdose cluster - Georgia, june 2017 - Edison L, Erickson A, Smith S, Lopez G, Hon S, King A, Nydam N, O'Neal JP, Drenzek C.
On June 5, 2017, a Georgia North-Central Health District emergency department (ED) notified the Georgia Poison Center of six opioid overdoses and one death during the previous day. All patients had severe respiratory depression, loss of consciousness, o... (Source: SafetyLit)
Source: SafetyLit - October 21, 2017 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Zimbabwe:World Health Organisation Appoints Mugabe as Africa's Goodwill Ambassador
[The Herald] Montevideo -President Mugabe will spearhead the fight against non-communicable diseases (NCDs) in Africa after he accepted a request by the World Health Organisation (WHO) to be its goodwill ambassador on the continent. The President is here for the WHO global conference on NCDs. NCDs are chronic diseases that cannot be passed from person-to-person and include cancer, diabetes, chronic respiratory and cardiovascular diseases. President Mugabe's acceptance of the challenge to lead Africa in the fight against NCDs was a (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 21, 2017 Category: African Health Source Type: news

Vyaire Medical acquires Revolutionary Medical Devices
Vyaire Medical, a joint venture from Becton Dickinson & Co. (NYSE:BDX) and Apax Partners, said today it acquired airway management developer Revolutionary Medical Devices for an undisclosed amount. Tucson, Ariz.-based Revolutionary Medical Devices’ main product is the SuperNO2VA, a noninvasive nasal positive airway pressure ventilation system designed to treat respiratory insufficiency from collapsed airways during or after sedation or during intubation. “The acquisition of Revolutionary Medical Devices allows Vyaire to bring another clinically-differentiated airway management solution to the medical d...
Source: Mass Device - October 20, 2017 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Mergers & Acquisitions Respiratory revolutionarymedicaldevices Vyaire Medical Source Type: news

Roundup: Digital health pharma news from Q3 2017
Pharma companies were fairly active in digital health in the third quarter of 2017, especially in the areas of diabetes and respiratory disease. Read on for a round-up of notable events. Diabetes management (Source: mobihealthnews)
Source: mobihealthnews - October 20, 2017 Category: Information Technology Source Type: news

New and emerging treatments for fungal infections.
Although several new antifungal drugs have been licensed in the last 5 years, some patients remain difficult to treat. The main reasons for this include intrinsic or acquired antifungal resistance, organ dysfunction preventing the use of some agents and drug interactions. In addition, some drugs penetrate poorly into sanctuary sites including eye and urine, and others are associated with considerable adverse events. Here, we review the preclinical and clinical development progress with four new antifungal agents: isavuconazole, ravuconazole,albaconazole and aminocandin. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Biafungin (CD101), a Novel Echinocandin, Displays a Long Half-life in the Chimpanzee, Suggesting a Once-Weekly IV Dosing Option
Background: The echinocandins are an important class of antifungal agents, but are administered oncedaily by intravenous (IV) infusion. An echinocandin that could be administered once weekly couldfacilitate earlier hospital discharges and could expand usage to indications where daily infusions areimpractical. Biafungin is a highly stable echinocandin for once-weekly IV administration. The compoundwas found to have a spectrum of activity and potency comparable to other echinocandins. In (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Biafungin (CD101), a Novel Echinocandin, Displays an Uncommonly Long Half-life in Multiple Species
Background: The echinocandins are an important class of antifungal agents, but areadministered once daily by intravenous (IV) infusion. An echinocandin that offers a convenientand more economic dosing schedule is desired.Biafungin is a highly stable echinocandin for intermittent IV administration. The compound wasfound to have a long half-life (T1/2), which may greatly reduce costs even as an IV therapythrough less frequent dosing, allowing earlier discharges for patients with negative fungal (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

C101 (biafungin) entry on BIOCENTURY
: http://bciq.biocentury.com/products/biafungin (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species
Novelmacrocyclic amidinourea derivatives 11, 18, and 25 were synthesized and evaluated as antifungal agentsagainstwild-type and fluconazoleresistantCandidaspecies. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Latest information on SCY-078 (MK-3118; enfumafungin) from Scynexis
From Scynexis website (as of 20/10/2017): (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Enfumafungin derivative MK-3118 shows increased in vitro potency against clinical echinocandin-resistant Candida Species and Aspergillus species isolates.
MK-3118 is as an orally active new antifungal in the early stage of clinical development that inhibits the biosynthesis of β-(1,3)-glucan. We evaluated the invitro activity of this compound against wild-type and echinocandin-resistant (ER) isolates containing mutations in the FKS gene(s) of Candida spp. and Aspergillus spp.MK-3118 demonstrated enhanced efficacy for most C. albicans and C. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Clone of Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.
The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro against 135 clinical non-Aspergillus mold isolates. Akin to echinocandins, SCY-078 showed no or poor activity against Mucoromycotina and Fusarium spp. However, SCY-078 was highly active against Paecilomyces variotii and was the only compound displaying some activity against notoriously panresistant Scedosporium prolificans. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Discovery of Plant Sterol-Derived Gamma-Secretase Modulators by Molecular Editing of a Triterpenoid Glycoside
Excerpt: (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating alpha-asarone-based HMG-CoA reductase inhibitors.
A series of alpha-asarone-based analogues was designed by conducting docking experiments with published crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a highly hypocholesterolemic in vivo activity in a murine model, as predicted by previous docking studies. In agreement with this model, the polar groups attached to the benzene ring could play a key role in the enzyme binding and probably also in its biological activity, mimicking the HMG-moiety of the natural substrate. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Diagnosis of invasive mould infection in haematology patients: the role of (1,3)-B-D-glucan
Friday, October 20, 2017 - 09:05Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

SCY-078 (Scynexis)
Friday, October 20, 2017 - 09:03Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Pollution Tied to 9 Million Deaths Worldwide in 2015
Title: Pollution Tied to 9 Million Deaths Worldwide in 2015Category: Health NewsCreated: 10/20/2017 12:00:00 AMLast Editorial Review: 10/20/2017 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - October 20, 2017 Category: Respiratory Medicine Source Type: news

E-cigarettes may trigger unique and potentially damaging immune responses
(American Thoracic Society) E-cigarettes appear to trigger unique immune responses as well as the same ones that cigarettes trigger that can lead to lung disease, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 20, 2017 Category: International Medicine & Public Health Source Type: news

In RA, COPD Admissions Rise (CME/CE)
(MedPage Today) -- Patients with rheumatoid arthritis had a 47% increased risk of hospitalization for COPD (Source: MedPage Today Pulmonary)
Source: MedPage Today Pulmonary - October 19, 2017 Category: Respiratory Medicine Source Type: news

Walking just 2 hours a week could prolong your life
Just two hours of walking a week could add years to your life. A new study of older adults revealed people who walk six hours or more a week have lower risk of dying from respiratory disease, cardiovascular disease and cancer. Dr. David Agus joins "CBS This Morning" to discuss the findings. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - October 19, 2017 Category: Consumer Health News Source Type: news

MRI Findings Prognostic for Long - Term Recovery in Cardiac Arrest
Cerebral functional network connectivity shows potential in anoxic - ischemic encephalopathy (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 19, 2017 Category: Respiratory Medicine Tags: Cardiology, Internal Medicine, Critical Care, Emergency Medicine, Neurology, Pulmonology, Radiology, Geriatrics, Journal, Source Type: news

‘Fishing rod’ made of DNA for monitoring antifungal concentrations in blood
‘Fishing rod’ made of DNA for monitoring antifungal concentrations in bloodThu, 10/19/2017 - 16:39News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 19, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Walking just two hours a week could prolong your life
Just two hours of walking a week could add years to your life. A new study of older adults revealed people who walk six hours or more a week have lower risk of dying from respiratory disease, cardiovascular disease and cancer. Dr. David Agus joins "CBS This Morning" to discuss the findings. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - October 19, 2017 Category: Consumer Health News Source Type: news

Zimbabwe:Govt in Drive to Contain NCDs
[The Herald] Government is making efforts to establish an Inter-Ministerial Task Force on Non-Communicable Diseases (NCDs) because such diseases need a multi-sectoral response, President Mugabe has said. NCDs are chronic diseases that cannot be passed from person-to-person and include cancer, diabetes, chronic respiratory and cardiovascular diseases. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 19, 2017 Category: African Health Source Type: news

Researchers are tracking pandemic potential of H7N9 bird flu in China
(Cell Press) As of Oct. 5, a total of 1,562 laboratory-confirmed cases of H7N9 avian flu virus have been reported to the World Health Organization, with more people getting infected each year. In a study published in the journal Cell Host& Microbe, researchers found that H7N9 viruses replicated efficiently in human airway cells and the lungs of animal models, spread among ferrets via respiratory droplets, and were minimally responsive to commonly used antiviral drugs. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 19, 2017 Category: Infectious Diseases Source Type: news

Appropriate Use Criteria Developed for Aortic Stenosis Tx
SAVR or TAVR appropriate for most patients with symptomatic AS at intermediate or high surgical risk (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 18, 2017 Category: Respiratory Medicine Tags: Cardiology, Nursing, Pulmonology, Surgery, Journal, Source Type: news

Men Now Comprise ~ 10 Percent of RN Workforce
About half of increase due to educational attainment, rising demand, liberalizing gender attitudes (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 18, 2017 Category: Respiratory Medicine Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Critical Care, Emergency Medicine, Nephrology, Neurology, Nursing, Oncology, Ophthalmology, Orthopedics, ENT, Source Type: news

Medical News Today: Could a protein from intestinal worms lead to a cure for asthma?
A new study shows that HpARI, a protein made by intestinal worms, could lead to treatments that reduce and prevent asthma and other allergic responses. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 18, 2017 Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

Postdoctoral Research Associate, Fungal Redox Mechanisms and Biomedical Pathogenesis - USA
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 18, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

C-Path and CDISC announce therapeutic area user guide for duchenne muscular dystrophy
(Critical Path Institute (C-Path)) C-Path and CDISC announce the availability of TAUG-DMD v1.0: a therapeutic area user guide that describes the most common clinical concepts relevant to Duchenne studies using the CDISC standard format, which allows datasets from different sources to be compared or combined for analysis. Data covered include genetic information, cardiac and respiratory data, as well as results from specific measurements of strength and function. Data standards are also being developed for a variety of functional assessments. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 18, 2017 Category: International Medicine & Public Health Source Type: news

Killer Fungus to take over Manchester Science Festival
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 17, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Preventing the spread of fungal disease between ʻōhiʻa trees in Hawaiʻi
Tue, 10/17/2017 - 10:41News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 17, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Kneeling Posture Impacts Chest Compressions ’ Effectiveness
Efficacy of CPR compressions better in self - adjusted, nearest kneeling postures versus farthest (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 17, 2017 Category: Respiratory Medicine Tags: Cardiology, Family Medicine, Geriatrics, Internal Medicine, Critical Care, Emergency Medicine, Nursing, Pulmonology, Journal, Source Type: news

Dark Skies and Chest Pain as California Fires Spew Smoke 100 Miles Dark Skies and Chest Pain as California Fires Spew Smoke 100 Miles
California's deadly wildfires have darkened the skies for a hundred miles, causing respiratory problems and making it hard to see the sun not only in the state's wine country but as far as San Francisco and Sacramento.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - October 16, 2017 Category: Allergy & Immunology Tags: Family Medicine/Primary Care News Source Type: news

ResMed claims wins, updates on continuing patent war with Fisher & Paykel
ResMed (NYSE:RMD) this month updated on a number of global patent infringement suits in the UK, Australia and New Zealand as it continues to battle with Fisher & Paykel Healthcare (NZE:FPH). The San Diego, Calif.-based company said that it has decided to proceed with the defense of 1 of 3 UK ResMed patents that were challenged by Fisher & Paykel while agreeing to revoke the other 2 patents. ResMed said that the revoked patent will “have no commercial impact on sales of ResMed’s products” and that it’s not binding on the European Patent Office or the German Courts. In Australia, Res...
Source: Mass Device - October 16, 2017 Category: Medical Devices Authors: Fink Densford Tags: Legal News Patent Infringement Respiratory Fisher & Paykel Healthcare ResMed Inc. Source Type: news

WHO to establish high-level commission on noncommunicable diseases
The commission's aim is to identify innovative ways to curb the world's biggest causes of death and extend life expectancy for millions of people. The commission will support ongoing political efforts to accelerate action on cardiovascular disease, cancers, diabetes and respiratory disease, as well as reducing suffering from mental health issues and the impacts of violence and injuries. (Source: PHPartners.org)
Source: PHPartners.org - October 16, 2017 Category: International Medicine & Public Health Source Type: news

Chronic Pulmonary Aspergillosis IV
Monday, October 16, 2017 - 08:36Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 16, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Chronic Pulmonary Aspergillosis III
Monday, October 16, 2017 - 08:35Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 16, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Chronic Pulmonary Aspergillosis II
Monday, October 16, 2017 - 08:34Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 16, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Chronic Pulmonary Aspergillosis I
Monday, October 16, 2017 - 08:32Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 16, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Current Medical Therapy for Sarcoidosis Current Medical Therapy for Sarcoidosis
What do we currently know about the indications for treatment and the efficacy of therapeutic options for sarcoidosis?Seminars in Respiratory and Critical Care Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 16, 2017 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

Endogenous infection marker guides antibiotic therapy
(University of Basel) The endogenous infection marker procalcitonin can help to guide the use of antibiotics when treating infections. The course of antibiotic therapy is shortened, and its side effects and mortality rate also decrease, as researchers from the University of Basel and other colleagues report in the journal The Lancet Infectious Diseases. They conducted a meta-analysis of over 6,700 international data sets from patients with respiratory infections. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 16, 2017 Category: Infectious Diseases Source Type: news

What Are the Health Needs of Incarcerated Youth?
Discussion In the US during 2011, ~60,000 youth were incarcerated at some time in a correctional facility. Boys are detained more than girls (86% vs 14% respectively in the US, 95% male in the United Kingdom in 2014) but girls have more health issues. There are racial and ethnic differences with 38-40% of detainees being black, 23% being Hispanic/Latino and 32% being white, and 5% other. For detained youth, 5% are for violent crimes, 22% for non-violent property crimes and the majority of the rest are for non-violent offices such as substance use. The average length of detainment is 3-4 months and unfortunately the rates o...
Source: PediatricEducation.org - October 16, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Procalcitonin-Guided Antibiotic Therapy Tied to Improved Survival in Acute Respiratory Infection (FREE)
By Amy Orciari Herman Edited by Susan Sadoughi, MD, and Andr é Sofair, MD, MPH For patients with acute respiratory tract infection, using procalcitonin levels to guide treatment decisions can reduce antibiotic use and improve survival, finds a meta-analysis in the Lancet Infectious Diseases. High procalcitonin levels can … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - October 16, 2017 Category: Primary Care Source Type: news