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New and emerging treatments for fungal infections.
Although several new antifungal drugs have been licensed in the last 5 years, some patients remain difficult to treat. The main reasons for this include intrinsic or acquired antifungal resistance, organ dysfunction preventing the use of some agents and drug interactions. In addition, some drugs penetrate poorly into sanctuary sites including eye and urine, and others are associated with considerable adverse events. Here, we review the preclinical and clinical development progress with four new antifungal agents: isavuconazole, ravuconazole,albaconazole and aminocandin. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Biafungin (CD101), a Novel Echinocandin, Displays a Long Half-life in the Chimpanzee, Suggesting a Once-Weekly IV Dosing Option
Background: The echinocandins are an important class of antifungal agents, but are administered oncedaily by intravenous (IV) infusion. An echinocandin that could be administered once weekly couldfacilitate earlier hospital discharges and could expand usage to indications where daily infusions areimpractical. Biafungin is a highly stable echinocandin for once-weekly IV administration. The compoundwas found to have a spectrum of activity and potency comparable to other echinocandins. In (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Biafungin (CD101), a Novel Echinocandin, Displays an Uncommonly Long Half-life in Multiple Species
Background: The echinocandins are an important class of antifungal agents, but areadministered once daily by intravenous (IV) infusion. An echinocandin that offers a convenientand more economic dosing schedule is desired.Biafungin is a highly stable echinocandin for intermittent IV administration. The compound wasfound to have a long half-life (T1/2), which may greatly reduce costs even as an IV therapythrough less frequent dosing, allowing earlier discharges for patients with negative fungal (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

C101 (biafungin) entry on BIOCENTURY
: http://bciq.biocentury.com/products/biafungin (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Novel Macrocyclic Amidinoureas: Potent Non-Azole Antifungals Active against Wild-Type and Resistant Candida Species
Novelmacrocyclic amidinourea derivatives 11, 18, and 25 were synthesized and evaluated as antifungal agentsagainstwild-type and fluconazoleresistantCandidaspecies. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Latest information on SCY-078 (MK-3118; enfumafungin) from Scynexis
From Scynexis website (as of 20/10/2017): (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Enfumafungin derivative MK-3118 shows increased in vitro potency against clinical echinocandin-resistant Candida Species and Aspergillus species isolates.
MK-3118 is as an orally active new antifungal in the early stage of clinical development that inhibits the biosynthesis of β-(1,3)-glucan. We evaluated the invitro activity of this compound against wild-type and echinocandin-resistant (ER) isolates containing mutations in the FKS gene(s) of Candida spp. and Aspergillus spp.MK-3118 demonstrated enhanced efficacy for most C. albicans and C. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Clone of Antifungal activities of SCY-078 (MK-3118) and standard antifungal agents against clinical non-Aspergillus mold isolates.
The limited armamentarium of active and oral antifungal drugs against emerging non-Aspergillus molds is of particular concern. Current antifungal agents and the new orally available beta-1,3-d-glucan synthase inhibitor SCY-078 were tested in vitro against 135 clinical non-Aspergillus mold isolates. Akin to echinocandins, SCY-078 showed no or poor activity against Mucoromycotina and Fusarium spp. However, SCY-078 was highly active against Paecilomyces variotii and was the only compound displaying some activity against notoriously panresistant Scedosporium prolificans. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Discovery of Plant Sterol-Derived Gamma-Secretase Modulators by Molecular Editing of a Triterpenoid Glycoside
Excerpt: (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating alpha-asarone-based HMG-CoA reductase inhibitors.
A series of alpha-asarone-based analogues was designed by conducting docking experiments with published crystal structures of human HMG-CoA reductase. Indeed, synthesis and evaluation of this series showed a highly hypocholesterolemic in vivo activity in a murine model, as predicted by previous docking studies. In agreement with this model, the polar groups attached to the benzene ring could play a key role in the enzyme binding and probably also in its biological activity, mimicking the HMG-moiety of the natural substrate. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Diagnosis of invasive mould infection in haematology patients: the role of (1,3)-B-D-glucan
Friday, October 20, 2017 - 09:05Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

SCY-078 (Scynexis)
Friday, October 20, 2017 - 09:03Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 20, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Pollution Tied to 9 Million Deaths Worldwide in 2015
Title: Pollution Tied to 9 Million Deaths Worldwide in 2015Category: Health NewsCreated: 10/20/2017 12:00:00 AMLast Editorial Review: 10/20/2017 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - October 20, 2017 Category: Respiratory Medicine Source Type: news

E-cigarettes may trigger unique and potentially damaging immune responses
(American Thoracic Society) E-cigarettes appear to trigger unique immune responses as well as the same ones that cigarettes trigger that can lead to lung disease, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 20, 2017 Category: International Medicine & Public Health Source Type: news

In RA, COPD Admissions Rise (CME/CE)
(MedPage Today) -- Patients with rheumatoid arthritis had a 47% increased risk of hospitalization for COPD (Source: MedPage Today Pulmonary)
Source: MedPage Today Pulmonary - October 19, 2017 Category: Respiratory Medicine Source Type: news

Walking just 2 hours a week could prolong your life
Just two hours of walking a week could add years to your life. A new study of older adults revealed people who walk six hours or more a week have lower risk of dying from respiratory disease, cardiovascular disease and cancer. Dr. David Agus joins "CBS This Morning" to discuss the findings. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - October 19, 2017 Category: Consumer Health News Source Type: news

MRI Findings Prognostic for Long - Term Recovery in Cardiac Arrest
Cerebral functional network connectivity shows potential in anoxic - ischemic encephalopathy (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 19, 2017 Category: Respiratory Medicine Tags: Cardiology, Internal Medicine, Critical Care, Emergency Medicine, Neurology, Pulmonology, Radiology, Geriatrics, Journal, Source Type: news

‘Fishing rod’ made of DNA for monitoring antifungal concentrations in blood
‘Fishing rod’ made of DNA for monitoring antifungal concentrations in bloodThu, 10/19/2017 - 16:39News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 19, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Walking just two hours a week could prolong your life
Just two hours of walking a week could add years to your life. A new study of older adults revealed people who walk six hours or more a week have lower risk of dying from respiratory disease, cardiovascular disease and cancer. Dr. David Agus joins "CBS This Morning" to discuss the findings. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - October 19, 2017 Category: Consumer Health News Source Type: news

Zimbabwe:Govt in Drive to Contain NCDs
[The Herald] Government is making efforts to establish an Inter-Ministerial Task Force on Non-Communicable Diseases (NCDs) because such diseases need a multi-sectoral response, President Mugabe has said. NCDs are chronic diseases that cannot be passed from person-to-person and include cancer, diabetes, chronic respiratory and cardiovascular diseases. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - October 19, 2017 Category: African Health Source Type: news

Researchers are tracking pandemic potential of H7N9 bird flu in China
(Cell Press) As of Oct. 5, a total of 1,562 laboratory-confirmed cases of H7N9 avian flu virus have been reported to the World Health Organization, with more people getting infected each year. In a study published in the journal Cell Host& Microbe, researchers found that H7N9 viruses replicated efficiently in human airway cells and the lungs of animal models, spread among ferrets via respiratory droplets, and were minimally responsive to commonly used antiviral drugs. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 19, 2017 Category: Infectious Diseases Source Type: news

Appropriate Use Criteria Developed for Aortic Stenosis Tx
SAVR or TAVR appropriate for most patients with symptomatic AS at intermediate or high surgical risk (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 18, 2017 Category: Respiratory Medicine Tags: Cardiology, Nursing, Pulmonology, Surgery, Journal, Source Type: news

Men Now Comprise ~ 10 Percent of RN Workforce
About half of increase due to educational attainment, rising demand, liberalizing gender attitudes (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 18, 2017 Category: Respiratory Medicine Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Critical Care, Emergency Medicine, Nephrology, Neurology, Nursing, Oncology, Ophthalmology, Orthopedics, ENT, Source Type: news

Medical News Today: Could a protein from intestinal worms lead to a cure for asthma?
A new study shows that HpARI, a protein made by intestinal worms, could lead to treatments that reduce and prevent asthma and other allergic responses. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 18, 2017 Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

Postdoctoral Research Associate, Fungal Redox Mechanisms and Biomedical Pathogenesis - USA
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 18, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

C-Path and CDISC announce therapeutic area user guide for duchenne muscular dystrophy
(Critical Path Institute (C-Path)) C-Path and CDISC announce the availability of TAUG-DMD v1.0: a therapeutic area user guide that describes the most common clinical concepts relevant to Duchenne studies using the CDISC standard format, which allows datasets from different sources to be compared or combined for analysis. Data covered include genetic information, cardiac and respiratory data, as well as results from specific measurements of strength and function. Data standards are also being developed for a variety of functional assessments. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 18, 2017 Category: International Medicine & Public Health Source Type: news

Killer Fungus to take over Manchester Science Festival
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 17, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Preventing the spread of fungal disease between ʻōhiʻa trees in Hawaiʻi
Tue, 10/17/2017 - 10:41News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 17, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Kneeling Posture Impacts Chest Compressions ’ Effectiveness
Efficacy of CPR compressions better in self - adjusted, nearest kneeling postures versus farthest (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 17, 2017 Category: Respiratory Medicine Tags: Cardiology, Family Medicine, Geriatrics, Internal Medicine, Critical Care, Emergency Medicine, Nursing, Pulmonology, Journal, Source Type: news

Dark Skies and Chest Pain as California Fires Spew Smoke 100 Miles Dark Skies and Chest Pain as California Fires Spew Smoke 100 Miles
California's deadly wildfires have darkened the skies for a hundred miles, causing respiratory problems and making it hard to see the sun not only in the state's wine country but as far as San Francisco and Sacramento.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - October 16, 2017 Category: Allergy & Immunology Tags: Family Medicine/Primary Care News Source Type: news

ResMed claims wins, updates on continuing patent war with Fisher & Paykel
ResMed (NYSE:RMD) this month updated on a number of global patent infringement suits in the UK, Australia and New Zealand as it continues to battle with Fisher & Paykel Healthcare (NZE:FPH). The San Diego, Calif.-based company said that it has decided to proceed with the defense of 1 of 3 UK ResMed patents that were challenged by Fisher & Paykel while agreeing to revoke the other 2 patents. ResMed said that the revoked patent will “have no commercial impact on sales of ResMed’s products” and that it’s not binding on the European Patent Office or the German Courts. In Australia, Res...
Source: Mass Device - October 16, 2017 Category: Medical Devices Authors: Fink Densford Tags: Legal News Patent Infringement Respiratory Fisher & Paykel Healthcare ResMed Inc. Source Type: news

WHO to establish high-level commission on noncommunicable diseases
The commission's aim is to identify innovative ways to curb the world's biggest causes of death and extend life expectancy for millions of people. The commission will support ongoing political efforts to accelerate action on cardiovascular disease, cancers, diabetes and respiratory disease, as well as reducing suffering from mental health issues and the impacts of violence and injuries. (Source: PHPartners.org)
Source: PHPartners.org - October 16, 2017 Category: International Medicine & Public Health Source Type: news

Chronic Pulmonary Aspergillosis IV
Monday, October 16, 2017 - 08:36Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 16, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Chronic Pulmonary Aspergillosis III
Monday, October 16, 2017 - 08:35Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 16, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Chronic Pulmonary Aspergillosis II
Monday, October 16, 2017 - 08:34Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 16, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Chronic Pulmonary Aspergillosis I
Monday, October 16, 2017 - 08:32Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 16, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Current Medical Therapy for Sarcoidosis Current Medical Therapy for Sarcoidosis
What do we currently know about the indications for treatment and the efficacy of therapeutic options for sarcoidosis?Seminars in Respiratory and Critical Care Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 16, 2017 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

Endogenous infection marker guides antibiotic therapy
(University of Basel) The endogenous infection marker procalcitonin can help to guide the use of antibiotics when treating infections. The course of antibiotic therapy is shortened, and its side effects and mortality rate also decrease, as researchers from the University of Basel and other colleagues report in the journal The Lancet Infectious Diseases. They conducted a meta-analysis of over 6,700 international data sets from patients with respiratory infections. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 16, 2017 Category: Infectious Diseases Source Type: news

What Are the Health Needs of Incarcerated Youth?
Discussion In the US during 2011, ~60,000 youth were incarcerated at some time in a correctional facility. Boys are detained more than girls (86% vs 14% respectively in the US, 95% male in the United Kingdom in 2014) but girls have more health issues. There are racial and ethnic differences with 38-40% of detainees being black, 23% being Hispanic/Latino and 32% being white, and 5% other. For detained youth, 5% are for violent crimes, 22% for non-violent property crimes and the majority of the rest are for non-violent offices such as substance use. The average length of detainment is 3-4 months and unfortunately the rates o...
Source: PediatricEducation.org - October 16, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Procalcitonin-Guided Antibiotic Therapy Tied to Improved Survival in Acute Respiratory Infection (FREE)
By Amy Orciari Herman Edited by Susan Sadoughi, MD, and Andr é Sofair, MD, MPH For patients with acute respiratory tract infection, using procalcitonin levels to guide treatment decisions can reduce antibiotic use and improve survival, finds a meta-analysis in the Lancet Infectious Diseases. High procalcitonin levels can … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - October 16, 2017 Category: Primary Care Source Type: news

Particle Pollution and Your Patients' Health: Evidence-Based Training for Healthcare Professionals
U.S. Environmental Protection Agency. 08/21/2017 This course explains particle pollution, also known as particulate matter or PM, which is the main component of haze, smoke, and dust. It explains what size particles are the greatest health concern, and where and when they are a problem. It identifies how particle pollution exposure affects the cardiovascular and respiratory systems, the general population, and patients with cardiovascular or respiratory disease. It explains the purpose and use of the Air Quality Index for advising patients how to protect their health. (Text) (Source: Disaster Lit: Resource Guide for Disast...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - October 14, 2017 Category: International Medicine & Public Health Authors: The U.S. National Library of Medicine Source Type: news

ZOLL Showcases New Ventilator Capabilities at AMTC 2017
CHELMSFORD, MASS.—ZOLL Medical Corporation, an Asahi Kasei Group Company that manufactures medical devices and related software solutions, will offer Air Medical Transport Conference 2017  (AMTC) attendees the opportunity to experience the new capabilities of its mechanical ventilation devices in booth 901 October 16-18 at the Fort Worth Convention Center in Fort Worth, Texas. Respiratory Care—Launching New Capabilities Using ZOLL’s EMV+ Ventilator, participants will experience firsthand how lungs adapt to each ventilator mode. With its unique Smart HelpT technology, ZOLL ventilators provid...
Source: JEMS: Journal of Emergency Medical Services News - October 13, 2017 Category: Emergency Medicine Authors: ZOLL Tags: Industry News Equipment & Gear Source Type: news

ZOLL Showcases New Ventilator Capabilities at AMTC 2017
CHELMSFORD, MASS.—ZOLL Medical Corporation, an Asahi Kasei Group Company that manufactures medical devices and related software solutions, will offer Air Medical Transport Conference 2017  (AMTC) attendees the opportunity to experience the new capabilities of its mechanical ventilation devices in booth 901 October 16-18 at the Fort Worth Convention Center in Fort Worth, Texas. Respiratory Care—Launching New Capabilities Using ZOLL’s EMV+ Ventilator, participants will experience firsthand how lungs adapt to each ventilator mode. With its unique Smart HelpT technology, ZOLL ventilators provid...
Source: JEMS Patient Care - October 13, 2017 Category: Emergency Medicine Authors: ZOLL Tags: Airway & Respiratory Cardiac Resuscitation Equipment Gear Operations Source Type: news

ZOLL Showcases New Ventilator Capabilities at AMTC 2017
CHELMSFORD, MASS.—ZOLL Medical Corporation, an Asahi Kasei Group Company that manufactures medical devices and related software solutions, will offer Air Medical Transport Conference 2017  (AMTC) attendees the opportunity to experience the new capabilities of its mechanical ventilation devices in booth 901 October 16-18 at the Fort Worth Convention Center in Fort Worth, Texas. Respiratory Care—Launching New Capabilities Using ZOLL’s EMV+ Ventilator, participants will experience firsthand how lungs adapt to each ventilator mode. With its unique Smart HelpT technology, ZOLL ventilators provid...
Source: JEMS Operations - October 13, 2017 Category: Emergency Medicine Authors: ZOLL Tags: Airway & Respiratory Cardiac Resuscitation Equipment Gear Operations Source Type: news

Propeller Health launches API to provide local asthma conditions to orgs, patients
Earlier this week, Propeller Health released an application programming interface to give local asthma conditions to anyone within the U.S. who is interested in using that data. The Air by Propeller API is a free service that uses a machine-learning model based on millions of days of anonymous asthma symptom data and environmental data. The model uses that information to predict potential effects on people’s breathing. Get the full story at our sister site, Drug Delivery Business News. The post Propeller Health launches API to provide local asthma conditions to orgs, patients appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - October 13, 2017 Category: Medical Devices Authors: Sarah Faulkner Tags: Big Data Health Information Technology Pharmaceuticals Respiratory Propeller Health Source Type: news

ResMed touts win in German patent spat with Fisher & Paykel
ResMed (NYSE:RMD) this week touted a win in a patent spat with Fisher & Paykel Healthcare (NZE:FPH) after a German court determined that its AirSense 10, AirCurve 10 and Lumis devices and included humidifiers do not infringe on a Fisher & Paykel patent. The decision was made by the Munich District Court, the San Diego, Calif.-based company said. ResMed added that although its patents were found to not infringe on the German utility model patent, it will continue to challenge the validity of the patent with the German Patent and Trademark Office. “We applaud the German court for its sensible app...
Source: Mass Device - October 13, 2017 Category: Medical Devices Authors: Fink Densford Tags: Legal News Patent Infringement Respiratory Fisher & Paykel Healthcare ResMed Inc. Source Type: news

Guidelines Needed for 6MWT in Idiopathic Pulmonary Fibrosis
No specific guidelines for use of six - minute walk test in growing population with IPF (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 13, 2017 Category: Respiratory Medicine Tags: Cardiology, Internal Medicine, Nursing, Pulmonology, Geriatrics, Journal, Source Type: news

Goldilocks and the three azoles
Friday, October 13, 2017 - 15:56Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news