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Local penny-stock biotech firm lays off 71% of employees
A Holliston-based biotech company that ’s been developing organ implants to treat cancers in the respiratory tract is laying off 71 percent of its workforce, or 17 employees, after an investor reversed course on plans to buy $3.1 million worth of shares of the company in a private placement. Biostage Inc. (OTC: BSTG) announced the sta ff cuts late Thursday, less than a week after being delisted from the Nasdaq exchange for having too low a stock price. The company’s shares haven’t closed above… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - October 13, 2017 Category: Pharmaceuticals Authors: Don Seiffert Source Type: news

Medical News Today: Childhood respiratory infections linked with celiac disease
New research concludes that respiratory infections in at-risk children may significantly increase the likelihood of developing celiac disease. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 13, 2017 Category: Consumer Health News Tags: Pediatrics / Children's Health Source Type: news

New Preparation of Itraconazole (Pulmazole) Gets FDA Approval
Fri, 10/13/2017 - 09:59News blog (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Voriconazole
Friday, October 13, 2017 - 09:48Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Isavuconazole
Friday, October 13, 2017 - 09:46Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

VL-2397 (Vical)
Friday, October 13, 2017 - 09:44Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

CD101 (Cidara)
Friday, October 13, 2017 - 09:42Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

APX001 (Amplyx)
Friday, October 13, 2017 - 09:41Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Galactomannan
Friday, October 13, 2017 - 09:37Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Mechanism of multidrug resistance
Friday, October 13, 2017 - 09:36Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

MALDI identification and more of mould
Friday, October 13, 2017 - 09:30Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Global burden of fungal infections
Friday, October 13, 2017 - 09:24Slide presentation (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 13, 2017 Category: Respiratory Medicine Authors: ROrritt Source Type: news

Trump Signs Executive Order to Allow Cheaper Health Plans Trump Signs Executive Order to Allow Cheaper Health Plans
The executive order would lift restrictions on association health plans, letting them sell less expensive, skimpier plans; short-term insurance plans, lasting for up to a year, could be sold.Medscape Medical News (Source: Medscape Pulmonary Medicine Headlines)
Source: Medscape Pulmonary Medicine Headlines - October 12, 2017 Category: Respiratory Medicine Tags: Family Medicine/Primary Care News Alert Source Type: news

2004 to 2014 Saw Increases in Risk Factors in Ischemic Stroke
Increases in prevalence of hypertension, diabetes, dyslipidemia, smoking, and drug abuse in AIS (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 12, 2017 Category: Respiratory Medicine Tags: Cardiology, Family Medicine, Geriatrics, Gynecology, Internal Medicine, Emergency Medicine, Neurology, Nursing, Pathology, Pulmonology, Journal, Source Type: news

Six - Month Tai Chi Program Improves Physical Activity in CHD
Improvements in activity, weight, QoL for patients with coronary heart disease refusing cardiac rehab (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 12, 2017 Category: Respiratory Medicine Tags: Cardiology, Family Medicine, Geriatrics, Gynecology, Internal Medicine, Nursing, Pulmonology, Surgery, Journal, Source Type: news

Boehringer Ingelheim, Anthem partner for largest real-world COPD trial
As part of a research collaboration launched in 2014, Boehringer Ingelheim and Anthem have partnered to study people with chronic obstructive pulmonary disease in real-world settings to assess how commonly-prescribed drugs may reduce the occurrence of COPD exacerbations. The team, which also includes Anthem’s outcomes research subsidiary HealthCore, plans to investigate whether adding an inhaled corticosteroid to a LAMA-LABA combination provides a meaningful benefit – a question under debate in the respiratory space. Get the full story at our sister site, Drug Delivery Business News. The post Boehring...
Source: Mass Device - October 12, 2017 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Drug-Device Combinations Pharmaceuticals Respiratory Wall Street Beat Anthem Inc. Boehringer Ingelheim Pharmaceuticals Source Type: news

MRC Centre for Medical Mycology Scholarships
(Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 12, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Website terms and conditions
Before becoming a member of the Aspergillus Website you must read ourTerms and ConditionsPost date: 12 Oct 2017 - 1:39pm (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 12, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Terms and conditions of use
Terms and ConditionsWebsite terms and conditions(1)         IntroductionThese terms and conditions govern your use of our website; by using our website, you accept these terms and conditions in full. If you disagree with any part of these terms and conditions, do not use our website.(2)         Intellectual property rightsPost date: 12 Oct 2017 - 8:47am (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 12, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

'Heat-Not-Burn Cigarettes' Aiming for U.S. Market
Title: 'Heat-Not-Burn Cigarettes' Aiming for U.S. MarketCategory: Health NewsCreated: 10/11/2017 12:00:00 AMLast Editorial Review: 10/12/2017 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - October 12, 2017 Category: Respiratory Medicine Source Type: news

More Hardcore Smokers Trying to Kick the Habit
Title: More Hardcore Smokers Trying to Kick the HabitCategory: Health NewsCreated: 10/11/2017 12:00:00 AMLast Editorial Review: 10/12/2017 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - October 12, 2017 Category: Respiratory Medicine Source Type: news

SGS and Bavarian Nordic developing challenge strain to combat respiratory virus ​
ZURICH (Reuters) - SGS and Bavarian Nordic are teaming up to develop a virus challenge strain to combat a common respiratory illness. (Source: Reuters: Health)
Source: Reuters: Health - October 12, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Medical License Questions Sway Doctors ’ Mental Health Help
Asking only about current mental health may encourage help - seeking behavior (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 12, 2017 Category: Respiratory Medicine Tags: Cardiology, Dermatology, Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Infections, AIDS, Internal Medicine, Allergy, Critical Care, Emergency Medicine, Nephrology, Neurology, Oncology, Ophthalmology, Orthopedics, ENT, Pathology Source Type: news

Fall in nurse numbers could threaten patient safety
NHS even less equipped to cope with demands of a winter already set to stretch it to the limit Related items fromOnMedica Number of EU nurses registering drops by 96% Number of UK nurses and midwives falling Action plan to revive general practice nursing Poor admin support hampering respiratory nurses ’ time with patients Unrelenting NHS pressure affecting cancer care, say GPs and nurses (Source: OnMedica Latest News)
Source: OnMedica Latest News - October 12, 2017 Category: UK Health Source Type: news

Death Toll from California Wildfires Expected to Rise
(MedPage Today) -- Hundreds treated in area hospitals for burns, respiratory issues (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - October 11, 2017 Category: Primary Care Source Type: news

Interference of griseofulvin with the segregation of chromosomes at mitosis in diploid Aspergillus nidulans
Low concentrations of the antibioticgriseofulvin were found to cause increased frequencies of somatic segregation due to chromosome nondisjunction in a diploid strain ofAspergillus nidulans. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Antifungal activity of statins against Aspergillus species
The cholesterol-lowering agents known as statins have in vitro activities against human pathogenic fungi, such as Candida species, Cryptococcus neoformans, and Zygomycetes. Synergy between statins and azoles against these fungi has also been reported. We evaluated the in vitro activities of two statins, lovastatin andsimvastatin, alone and in combination with azoles and amphotericin B, against clinical isolates ofAspergillus spp. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Growth inhibition of Candida species and Aspergillus fumigatus by statins.
Statins are a class of drugs widely used for lowering high cholesterol levels through their action on 3-hydroxy-3-methylglutaryl-CoA reductase, a key enzyme in the synthesis of cholesterol. We studied the effects of two major statins,simvastatin and atorvastatin, on five Candida species andAspergillus fumigatus. The statins strongly inhibited the growth of all species, except Candida krusei. Supplementation of Candida albicans and A. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Efficacy and tolerability of amorolfine 5% nail lacquer in combination with systemic antifungal agents for onychomycosis: A meta-analysis and systematic review
The efficacy and safety of amorolfine 5% nail lacquer in combination with systemic antifungal agents in the treatment of the onychomycosis were evaluated. According to our meta-analysis, combination treatment of amorolfine 5% nail lacquer and systemic antifungals can result in higher percentage of complete clearance of onychomycosis. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Patient-reported outcomes from two randomised studies comparing once-weekly application of amorolfine 5% nail lacquer to other methods of topical treatment in distal and lateral subungual onychomycosis
The objective of this study was to investigate patient-reported outcomes (treatment utilisation, adherence and satisfaction) in onychomycosis treated with once-weeklyamorolfine 5% nail lacquer versus once-daily ciclopirox 8% nail lacquer (Study A) or once-daily urea 40% ointment/bifonazole 1% cream combination regimen (Study B). Study A: Subjects receivedamorolfine and ciclopirox on opposite feet for 12  weeks. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin H
Ilicicolin H is a polyketide-nonribosomal peptide synthase (NRPS)-natural product isolated from Gliocadium roseum, which exhibits potent and broad spectrum antifungal activity, with sub- μg/mL MICs against Candida spp., Aspergillus fumigatus, and Cryptococcus spp. It showed a novel mode of action, potent inhibition (IC50 = 2-3 ng/mL) of the mitochondrial cytochrome bc1 reductase, and over 1000-fold selectivity relative to rat liver cytochrome bc1 reductase. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis
Ambruticins are a family of polyketides. The antifungal activity of an ambruticin,KOSN-2079, was tested in the mouse model of invasive aspergillosis.KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Antifungal activities of R-135853, a sordarin derivative, in experimental candidiasis in mice
The activities ofR-135853, a novel sordarin derivative that possesses a 1,4-oxazepane ring moiety, were evaluated in vitro and in vivo.R-135853 exhibited potent in vitro activities against Candida albicans (fluconazole-susceptible strains), Candida glabrata, Candida tropicalis, and Cryptococcus neoformans, with MICs at which 90% of isolates were inhibited of 0.03, 1, 0.5, and 0.5 microg/ml, respectively. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

In Vitro and In Vivo Activity of a Novel Antifungal Small Molecule against Candida Infections
Candida is the most common fungal pathogen of humans worldwide and has become a major clinical problem because of the growing number of immunocompromised patients, who are susceptible to infection. Moreover, the number of available antifungals is limited, and antifungal-resistantCandida strains are emerging. New and effective antifungals are therefore urgently needed. Here, we discovered a small molecule with activity againstCandida spp. bothin vitro andin vivo. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids
Recent estimates suggest that>300 million people are afflicted by serious fungal infections worldwide. Currentantifungal drugs are static and toxic and/or have a narrow spectrum of activity. Thus, there is an urgent need for the development of newantifungal drugs. The fungal sphingolipid glucosylceramide (GlcCer) is critical in promoting virulence of a variety of human-pathogenic fungi. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 11, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Is Pleurisy Contagious?
Title: Is Pleurisy Contagious?Category: Diseases and ConditionsCreated: 3/15/2016 12:00:00 AMLast Editorial Review: 10/11/2017 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - October 11, 2017 Category: Respiratory Medicine Source Type: news

Disaster Cleanup and Recovery PPE (Personal Protective Equipment) Matrix
Occupational Safety and Health Administration [U.S. Department of Labor]. 10/2016 This two-page document and matrix will assist employers in determining the personal protective equipment (PPE) needed for the hazards that workers engaged in disaster cleanup and recovery activities may be exposed to. It also discusses respiratory protection, and sanitation and hygiene. (PDF) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - October 11, 2017 Category: International Medicine & Public Health Authors: The U.S. National Library of Medicine Source Type: news

Rapid Risk Assessment: Public Health Risks Related to Communicable Diseases During the Hajj 2017, Saudi Arabia, 30 August-4 September 2017
European Union, European Centre for Disease Prevention and Control. 08/10/2017 This 13-page report assesses the potential health risks for communicable diseases and other health threats for European citizens during their stay in Saudi Arabia for the Hajj pilgrimage on August 30-September 4, 2017. The risk of communicable disease outbreaks is highest for food- and waterborne diseases and respiratory illnesses due to crowding, but the risk is not considered higher than expected for international mass gatherings. MERS-CoV activity continues to be reported in the Arabian Peninsula, and imported cases may be detected in Europe ...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - October 11, 2017 Category: International Medicine & Public Health Authors: The U.S. National Library of Medicine Source Type: news

Propeller Health releases asthma forecasting API for open use
Madison, Wisconsin-based Propeller Health is taking its asthma alert messaging to the masses, as the longtime digital respiratory health company announced today that it is releasing Air, a free and open API that provides information on local asthma conditions. (Source: mobihealthnews)
Source: mobihealthnews - October 10, 2017 Category: Information Technology Source Type: news

New Connected Devices Seek to Tackle Drug Noncompliance
Noncompliance with drug regimens continues to be a significant healthcare concern. “Today, 60% of patients fail to comply with their medication regimen,” Sai Shankar, director business development - connected devices for Aptar Pharma, tells MD+DI.   Aptar Pharma believes that turning metered-dose inhalers (MDIs) and dry-powder inhalers (DPIs) into connected devices could have an impact. “This can improve patient engagement and significantly increase dose adherence and improve patient health outcomes, as patients manage their treatments more effectively,” says Shankar. “Connected ...
Source: MDDI - October 10, 2017 Category: Medical Devices Authors: Daphne Allen Tags: Digital Health Source Type: news

Respicardia wins FDA nod for Remed ē central sleep apnea neurostim device
Respicardia said today that it won FDA approval for its Remedē transvenous implantable neurostimulation system designed to treat patients with central sleep apnea. Central sleep apnea occurs when the brain fails to control breathing during sleep, unlike the more common obstructive sleep apnea which consists of a partially collapsed airway which causes pauses in breathing, Respicardia said. The Remedē system consists of a surgically placed battery packa nd thin wires inserted into the blood vessels in the chest near the phrenic nerve, which it stimulates to engage the diaphragm to restore natural breating during sleep and...
Source: Mass Device - October 10, 2017 Category: Medical Devices Authors: Fink Densford Tags: Food & Drug Administration (FDA) Neuromodulation/Neurostimulation Regulatory/Compliance Respiratory Respicardia Source Type: news

Medtronic breaks ground on western China Innovation Center
Medtronic (NYSE:MDT) said today it has begun work on an Innovation Center in Chengdu, China, slated to open in 2020. The new Chengdu Innovation Center is being built at the Singapore-Sichuan Hi-Tech Innovation Park in the Sichuan Province and aims to provide clinical training and research platforms for medical workers in the region and neighboring regions. “Medtronic understands the critical role that rural physicians play in driving the healthcare availability and transformation. As such, we hope to support the growth and development of medical workers in China’s vast central and western regions, help the...
Source: Mass Device - October 10, 2017 Category: Medical Devices Authors: Fink Densford Tags: Business/Financial News Medtronic Source Type: news

Drugs in Clinical Development for Fungal Infections (includes MAT023, encochleated amphotericin B))
Despite increasing rates of invasive fungal infections being reported globally, only a single antifungal drug has been approved during the last decade. Resistance, toxicity, drug interactions and restricted routes of administration remain unresolved issues. This review focuses on new antifungal compounds which are currently in various clinical phases of development. We discuss two azoles with a tetrazole moiety that allows selective activity against the fungal CYP: VT-1161 for Candida infections and VT-1129 for cryptococcal meningoencephalitis. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 10, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Antitumor/Antifungal Celecoxib Derivative AR-12 is a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl CoA Synthetase
AR-12/OSU-03012 is an antitumor celecoxib-derivative that has progressed to Phase I clinical trial as an anticancer agent and has activity against a number of infectious agents including fungi, bacteria and viruses. However, the mechanism of these activities has remained unclear. Based on a chemical-genetic profiling approach in yeast, we have found thatAR-12 is an ATP-competitive, time-dependent inhibitor of yeast acetyl coenzyme A synthetase. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 10, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis
Only one new class of antifungal drugs has been introduced into clinical practice in the last 30 years, and thus the identification of small molecules with novel mechanisms of action is an important goal of current anti-infective research. Here, we describe the characterization of the spectrum of in vitro activity and in vivo activity ofAR-12, a celecoxib derivative which has been tested in a phase I clinical trial as an anticancer agent. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 10, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition
The synthesis and antifungal activity ofASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition and significantly improved MIC against Candida parapsilosis and echinocandin resistant-Candida is described. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 10, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Efficacy of the investigational echinocandin ASP9726 in a guinea pig model of invasive pulmonary aspergillosis
ASP9726 is an investigational echinocandin with in vitro activity against Aspergillus species. We evaluated the pharmacokinetics and efficacy of this agent in an established guinea pig model of invasive pulmonary aspergillosis.ASP9726 plasma concentrations were measured in guinea pigs administered either a single dose or multiple doses of this agent at 2.5, 5, and 10 mg/kg of body weight/day by subcutaneous injection. Immunosuppressed guinea pigs were inoculated with A. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 10, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Generation of Broad-Spectrum Antifungal Drug Candidates from the Natural Product Compound Aureobasidin A
This report describes novel chemistry for the modification of AbA. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 10, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

An aureobasidin A resistance gene isolated from Aspergillus is a homolog of yeast AUR1, a gene responsible for inositol phosphorylceramide (IPC) synthase activity.
We report the molecular cloning and characterization of the Aspergillus nidulans aurA gene, which is homologous to AUR1. A single point mutation in the aurA gene of A. nidulans confers a high level of resistance toaureobasidin A. The A. nidulans aurA gene was used to identify its homologs in other Aspergillus species, including A. fumigatus, A. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 10, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news

Structure of aureobasidin A
Aureobasidin A, a new antifungal antibiotic, was isolated from the culture medium of Aureobasidium pullulans R106.Aureobasidin A was a cyclic depsipeptide consisting of eight alpha-amino acid units and one hydroxy acid unit. The structures of the units were found by acid hydrolysis of the antibiotic to be 2(R)-hydroxy-3(R)-methylpentanoic acid, beta-hydroxy-N-methyl-L-valine, N-methyl-L-valine, L-proline, allo-L-isoleucine, N-methyl-L-phenylalanine, L-leucine, and L-phenyl-alanine. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - October 10, 2017 Category: Respiratory Medicine Authors: BethBradshaw Source Type: news