EMA Backs Dexamethasone for Severe COVID-19 After Data Review EMA Backs Dexamethasone for Severe COVID-19 After Data Review
Dexamethasone can be considered a treatment option for adults and adolescents with SARS-CoV-2 infection who require supplemental oxygen therapy.International Approvals (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - September 19, 2020 Category: Infectious Diseases Tags: Infectious Diseases News Alert Source Type: news

Mutant virus: should we be worried that Sars-CoV-2 is changing?
Scientists tracking the virus have uncovered a major mutation, but it may not be as scary as it soundsCoronavirus – latest updatesSee all our coronavirus coverageScientists have had eyes on Sars-CoV-2, the virus that causes Covid-19, since the beginning of this pandemic.They can see it is evolving, but it is happening at a glacial pace compared with two other viruses with pandemic potential: those that cause flu and Aids. That is good news for efforts to develop vaccines and treatments, but scientists remain wary that anything could still happen.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - September 18, 2020 Category: Science Authors: Laura Spinney Tags: Coronavirus outbreak Infectious diseases Medical research Microbiology Science World news Vaccines and immunisation Health Source Type: news

Africa: WHO Encouraged by South Africa's Declining Covid-19 Trend
[WHO] Brazzaville -- The World Health Organization (WHO) commends the government of South Africa for its determined efforts that have helped to bend the COVID-19 pandemic curve. WHO is greatly encouraged by the ongoing measures to suppress the spread of SARs-COV-2, the virus that causes COVID-19. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - September 18, 2020 Category: African Health Source Type: news

Roche launches new quantitative antibody test to measure SARS-CoV-2 antibodies, to support the evaluation of vaccines
Basel, 18 September 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced the launch of its Elecsys ® Anti-SARS-CoV-2 S antibody test for markets accepting the CE Mark. Roche has filed for Emergency Use Authorisation (EUA) from the U.S. Food and Drug Administration (FDA). The Elecsys Anti-SARS-CoV-2 serology test can be used to quantitatively measure antibodies in people who have been exposed to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and can play an important part in characterising a vaccine-induced immune response.1 Specifically, the test targets antibodies which are directed against the ...
Source: Roche Media News - September 18, 2020 Category: Pharmaceuticals Source Type: news

Roche launches new quantitative antibody test to measure SARS-CoV-2 antibodies, to support the evaluation of vaccines
Basel, 18 September 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced the launch of its Elecsys ® Anti-SARS-CoV-2 S antibody test for markets accepting the CE Mark. Roche has filed for Emergency Use Authorisation (EUA) from the U.S. Food and Drug Administration (FDA). The Elecsys Anti-SARS-CoV-2 serology test can be used to quantitatively measure antibodies in people who have been exposed to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and can play an important part in characterising a vaccine-induced immune response.1 Specifically, the test targets antibodies which are directed against the ...
Source: Roche Investor Update - September 18, 2020 Category: Pharmaceuticals Source Type: news

After developing CRISPR test, UConn researchers validate clinical feasibility for COVID-19 testing
(University of Connecticut) In March, researchers in the Department of Biomedical Engineering-- a shared department in the schools of Dental Medicine, Medicine, and Engineering--began to develop a new, low-cost, CRISPR-based diagnostic platform to detect infectious diseases, including HIV virus, the novel coronavirus (SARS-CoV-2). Today, the method is one step closer to being a cutting-edge diagnostics technology for rapid detection of infectious diseases. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 18, 2020 Category: Biology Source Type: news

Potential new drug to mitigate SARS-CoV-2 infection consequences
(University of Malaga) Researchers at the University of Malaga study how '4-PBA' treatment modulates the inflammatory response in severe cases of COVID-19 (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 18, 2020 Category: Biology Source Type: news

New method identifies antibody-like proteins with diagnostic and therapeutic potential for SARS-CoV-2
(American Association for the Advancement of Science) Scientists have used a new high-speed,in vitro selection method to isolate 9 antibody-like proteins (ALPs) that bind to the SARS-CoV-2 virus - 4 of which also exhibited neutralizing activity - within 4 days, according to a new study. While much research has (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 18, 2020 Category: Infectious Diseases Source Type: news

T cells may be dealing the killer blow to coronavirus more than antibodies, say researchers
The researchers said their new study was in line with other data that showed the T cells and the killer T cell had a bigger part to play in protecting an individual against the SARS-Cov2 virus than antibodies. (Source: The Economic Times)
Source: The Economic Times - September 18, 2020 Category: Consumer Health News Source Type: news

Convalescent Plasma May Be an Option for Life-Threatening Pediatric COVID-19 Convalescent Plasma May Be an Option for Life-Threatening Pediatric COVID-19
A small case series suggests convalescent plasma may be safe and'possibly'effective in children with life-threatening SARS-CoV-2- associated acute respiratory distress syndrome.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - September 17, 2020 Category: Intensive Care Tags: Pediatrics News Source Type: news

FDA Compares Performance of COVID-19 Diagnostic Tests FDA Compares Performance of COVID-19 Diagnostic Tests
The agency plans to continue updating information on authorized SARS-CoV-2 test performance going forward.Medscape Medical News (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - September 17, 2020 Category: Infectious Diseases Tags: Pathology & Lab Medicine News Source Type: news

SARS-CoV-2-Associated Deaths Among Persons Aged < 21 Years - United States, February 12-July 31, 2020
This report describes SARS-CoV-2-associated deaths among persons aged (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - September 17, 2020 Category: American Health Tags: Children's Health MMWR Morbidity & Mortality Weekly Report SARS (Severe acute respiratory syndrome) COVID-19 Coronavirus Disease 2019 Source Type: news

Transmission Dynamics of COVID-19 Outbreaks Associated with Child Care Facilities - Salt Lake City, Utah, April-July 2020
This report describes transmission of SARS-CoV-2 among household members following exposure of 46 non-child care facility contacts linked to 12 children with COVID-19. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - September 17, 2020 Category: American Health Tags: MMWR Morbidity & Mortality Weekly Report Child Care COVID-19 Coronavirus Disease 2019 Source Type: news

Serial Testing for SARS-CoV-2 and Virus Whole Genome Sequencing Inform Infection Risk at Two Skilled Nursing Facilities with COVID-19 Outbreaks - Minnesota, April-June 2020
This report describes how serial COVID-19 testing and genome sequencing in skilled nursing facilities in Minnesota led to early identification of infections. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - September 17, 2020 Category: American Health Tags: MMWR Morbidity & Mortality Weekly Report COVID-19 Coronavirus Disease 2019 Source Type: news

Evidence summary for the duration of infectiousness in those that test positive for SARS-CoV-2 RNA
The Health Information and Quality Authority (HIQA) has developed a series of'Evidence Summaries'to assist the Expert Advisory Group (EAG) in supporting the National Public Health Emergency Team (NPHET) in their response to COVID-19. These summaries are based on specific research questions. This evidence summary was developed to address the following research question: What is the duration of infectiousness in those that test positive for SARSCoV-2 RNA? (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 17, 2020 Category: Consumer Health News Source Type: news

Baseline projections of COVID-19 in the EU/EEA and the UK: update, ECDPC
In this report, we present updated 30-day projections, together with a visual validation of the original forecasts. We continue to model a baseline'status quo'scenario, assuming all control measures in place on 8 September 2020 will be continued until the end of the projection period (14 October 2020). In this version, we have included data on testing rates to simulate the increased ascertainment of milder cases. For almost all countries, testing data is correct until 23 August. We have also included the use of face masks (both mandatory and voluntary) as a means for reducing both transmission and susceptibility to infecti...
Source: Current Awareness Service for Health (CASH) - September 17, 2020 Category: Consumer Health News Source Type: news

Natural selection versus creation: a review on the origin of SARS-COV-2 - Barh D, Silva Andrade B, Tiwari S, Giovanetti M, G óes-Neto A, Alcantara LCJ, Azevedo V, Ghosh P.
SARS-CoV-2 has created a global disaster by infecting millions of people and causing thousands of deaths across hundreds of countries. Currently, the infection is in its exponential phase in several countries and there is no sign of immediate relief from t... (Source: SafetyLit)
Source: SafetyLit - September 17, 2020 Category: International Medicine & Public Health Tags: Commentary Source Type: news

Rapid test for Covid-19 shows improved sensitivity
(Massachusetts Institute of Technology) A CRISPR-based diagnostic for the SARS-Cov-2 virus can produce results in less than an hour with similar accuracy as the standard PCR test now used. Development of the Covid-19 test was led by researchers at MIT and the Broad Institute of MIT and Harvard. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 17, 2020 Category: Infectious Diseases Source Type: news

Analysis of COVID-19 publications identifies research gaps
(Cell Press) Since the start of the COVID-19 pandemic, scientific and medical journals have published over 100,000 studies on SARS-CoV-2. But according to data scientists who created a machine-learning tool to analyze the deluge of publications, basic lab-based studies on the microbiology of the virus, including research on its pathogenesis and mechanisms of viral transmission, are lacking. Their analysis appears September 16 in the journal Patterns. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 17, 2020 Category: Infectious Diseases Source Type: news

Scientists uncover the structural mechanism of coronavirus receptor binding
(The Francis Crick Institute) The spike protein on the surface of the SARS-CoV-2 coronavirus can adopt at least ten distinct structural states, when in contact with the human virus receptor ACE2, according to research from the Francis Crick Institute published in Nature today (Thursday). (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 17, 2020 Category: Infectious Diseases Source Type: news

Study shows first proof that a safer UV light effectively kills virus causing COVID-19
(Hiroshima University) Researchers offer first proof that Ultraviolet C light with a 222 nm wavelength -- which is safer to use around humans -- effectively kills the SARS-CoV-2 virus. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 17, 2020 Category: Infectious Diseases Source Type: news

Efficacy of povidone-iodine nasal antiseptic for rapid inactivation of SARS-CoV-2
(JAMA Network) This laboratory study assessed the efficacy of the   nasal antiseptic solution povidone-iodine against transmission of SARS-C0V-2. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 17, 2020 Category: Infectious Diseases Source Type: news

NRL, NCATS scientists develop method to safely study COVID-19, other contagious diseases
(Naval Research Laboratory) Scientists and researchers at NRL and the National Center for Advancing Translational Sciences collaborate to develop SARS-CoV-2 nanoparticle probes that are used to study fundamental interactions between SARS-CoV-2 Spike proteins and human cells. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 17, 2020 Category: Biology Source Type: news

Stabilizing the prefusion SARS-CoV-2 spike
(Source: ScienceNOW)
Source: ScienceNOW - September 17, 2020 Category: Science Authors: Vinson, V. Tags: Biochemistry, Virology twis Source Type: news

A steric block to SARS-CoV-2
(Source: ScienceNOW)
Source: ScienceNOW - September 17, 2020 Category: Science Authors: Vinson, V. Tags: Biochemistry, Microbiology twis Source Type: news

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes
The coronavirus disease 2019 (COVID-19) pandemic has led to accelerated efforts to develop therapeutics and vaccines. A key target of these efforts is the spike (S) protein, which is metastable and difficult to produce recombinantly. We characterized 100 structure-guided spike designs and identified 26 individual substitutions that increased protein yields and stability. Testing combinations of beneficial substitutions resulted in the identification of HexaPro, a variant with six beneficial proline substitutions exhibiting higher expression than its parental construct (by a factor of 10) as well as the ability to withstand...
Source: ScienceNOW - September 17, 2020 Category: Science Authors: Hsieh, C.-L., Goldsmith, J. A., Schaub, J. M., DiVenere, A. M., Kuo, H.-C., Javanmardi, K., Le, K. C., Wrapp, D., Lee, A. G., Liu, Y., Chou, C.-W., Byrne, P. O., Hjorth, C. K., Johnson, N. V., Ludes-Meyers, J., Nguyen, A. W., Park, J., Wang, N., Amengor, Tags: Biochemistry, Virology reports Source Type: news

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. There are no approved vaccines or therapeutics for treating COVID-19. Here we report a humanized monoclonal antibody, H014, that efficiently neutralizes SARS-CoV-2 and SARS-CoV pseudoviruses as well as authentic SARS-CoV-2 at nanomolar concentrations by engaging the spike (S) receptor binding domain (RBD). H014 administration reduced SARS-CoV-2 titers in infected lungs and prevented pulmonary pathology in a human angiotensin-converting enzyme 2 mouse ...
Source: ScienceNOW - September 17, 2020 Category: Science Authors: Lv, Z., Deng, Y.-Q., Ye, Q., Cao, L., Sun, C.-Y., Fan, C., Huang, W., Sun, S., Sun, Y., Zhu, L., Chen, Q., Wang, N., Nie, J., Cui, Z., Zhu, D., Shaw, N., Li, X.-F., Li, Q., Xie, L., Wang, Y., Rao, Z., Qin, C.-F., Wang, X. Tags: Biochemistry, Microbiology reports Source Type: news

Blood Clotting Tied to Worse COVID-19 Outcomes
While it's not clear precisely how SARS-CoV-2 causes clots, a new study suggests that the amount of a particular protein -- called factor V -- in a patient's blood may have something to do with it. (Source: WebMD Health)
Source: WebMD Health - September 16, 2020 Category: Consumer Health News Source Type: news

Characteristics ID'd for Under 21s With SARS-CoV-2-Linked Deaths
WEDNESDAY, Sept. 16, 2020 -- Of those aged younger than 21 years with deaths associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), most are aged 10 to 20 years, and 75 percent of deaths occur in those with an underlying... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 16, 2020 Category: Pharmaceuticals Source Type: news

EARLY RELEASE: SARS-CoV-2 Infection Among Hospitalized Pregnant Women: Reasons for Admission and Pregnancy Characteristics - Eight U.S. Health Care Centers, March 1-May 30, 2020
This report describes that the prevalences of prepregnancy obesity and gestational diabetes were higher among pregnant women hospitalized for COVID-19-related illness than among those admitted for pregnancy-related treatment or procedures and found to have COVID-19. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - September 16, 2020 Category: American Health Tags: Diabetes MMWR Morbidity & Mortality Weekly Report Pregnancy COVID-19 Coronavirus Disease 2019 Source Type: news

Cochrane publishes three rapid reviews of the evidence on different public health measures to slow the spread of COVID-19
Cochrane has published an updated  special collection of systematic and rapid reviews  focused on a range of public health measures to control and prevent the spread of COVID-19. Many countries have adopted combinations of these measures and are faced with the challenge of easing or strengthening each of these measures over the course of the pandemic.Coronavirus disease 2019 (COVID-19) is caused by a new virus, SARS-CoV-2, that has spread quickly throughout the world. As there is currently no effective treatment or vaccine for COVID-19 other ways of slowing its spread are needed. What’s new in the Coch...
Source: Cochrane News and Events - September 16, 2020 Category: Information Technology Authors: Katie Abbotts Source Type: news

No Transmission of SARS-CoV-2 After Exposure at a Hair Salon No Transmission of SARS-CoV-2 After Exposure at a Hair Salon
This case of two COVID-19 symptomatic hair stylists who, along with their clients, wore masks, underscores the real-world effectiveness of face coverings for minimizing spread of SARS-CoV-2.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 16, 2020 Category: Consumer Health News Tags: Public Health & Prevention Journal Article Source Type: news

T cells take the lead in controlling SARS-CoV-2 and reducing COVID-19 disease severity
Ever since SARS-CoV-2 first appeared, researchers have been trying to understand whether sometimes the immune system does more harm than good during the acute phase of COVID-19. The latest study by researchers at La Jolla Institute for Immunology clearly argues in favor of the immune system. (Source: World Pharma News)
Source: World Pharma News - September 16, 2020 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Elevated Blood Clotting Factor Linked to Worse COVID-19 Outcomes
WEDNESDAY, Sept. 16, 2020 -- Most people now know that COVID-19 can cause blood clots, potentially leading to paralysis, stroke, heart attack and death. While it's not clear precisely how SARS-CoV-2 causes clots, a new study suggests that the... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 16, 2020 Category: General Medicine Source Type: news

Designed antiviral proteins inhibit SARS-CoV-2 in the lab
Computer-designed small proteins have now been shown to protect lab-grown human cells from SARS-CoV-2, the coronavirus that causes COVID-19. In the experiments, the lead antiviral candidate, named LCB1, rivaled the best-known SARS-CoV-2 neutralizing antibodies in its protective actions. LCB1 is currently being evaluated in rodents. (Source: World Pharma News)
Source: World Pharma News - September 16, 2020 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Trump Says With ‘A Herd Mentality’ Covid-19 Coronavirus Will Go Away
During an ABC News town hall in Pennsylvania with George Stephanopoulos, he continued to insist that the SARS-CoV2 will disappear, even without a vaccine. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - September 16, 2020 Category: Pharmaceuticals Authors: Bruce Y. Lee, Senior Contributor Tags: Healthcare /healthcare Innovation /innovation Science /science Coronavirus business pharma Source Type: news

Sanford Burnham Prebys receives $3M NIH award for drugs that restore immune response to COVID-19
(Sanford Burnham Prebys Medical Discovery Institute) Scientists at Sanford Burnham Prebys Medical Discovery Institute have received a $3 million grant from the National Institutes of Health (NIH) to study how SARS-CoV-19 weakens the immune system -- and identify drugs to help infected individuals recover. The research will be led by Carl Ware, Ph.D., director of the Institute's Infectious and Inflammatory Disease Center, and builds on the Institute-wide initiative to develop therapeutics to treat COVID-19. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 16, 2020 Category: Biology Source Type: news

Viral load predicts mortality rate in hospitalized patients with cancer and COVID-19
(Cell Press) Higher viral loads are associated with a greater risk of death among cancer and non-cancer patients hospitalized with coronavirus disease 2019 (COVID-19), researchers report September 15 in the journal Cancer Cell. Among hospitalized COVID-19 patients, those with hematologic malignancies who had recently been treated for cancer had the highest levels of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 16, 2020 Category: International Medicine & Public Health Source Type: news

T cells take the lead in controlling SARS-CoV-2 and reducing COVID-19 disease severity
(La Jolla Institute for Immunology) A multi-layered, virus-specific immune response is important for controlling SARS-CoV-2 during the acute phase of the infection and reducing COVID-19 disease severity, with the bulk of the evidence pointing to a much bigger role for T cells than antibodies. A weak or uncoordinated immune response, on the other hand, predicts a poor disease outcome. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 16, 2020 Category: Infectious Diseases Source Type: news

Individual EUAs for Molecular Diagnostic Tests for SARS-CoV-2
This table includes information about authorized SARS-CoV-2 molecular diagnostic tests. These EUAs have been issued for each individual test with certain conditions of authorization required of the manufacturer and authorized laboratories. (Source: FDA.gov) Visit our Lab Resource Center. The post Individual EUAs for Molecular Diagnostic Tests for SARS-CoV-2 first appeared on Dark Daily. (Source: Dark Daily)
Source: Dark Daily - September 16, 2020 Category: Laboratory Medicine Authors: Jude Tags: Laboratory News Laboratory Operations Laboratory Pathology Precision Medicine EUAs molecular diagnostic testing SARS-CoV-2 Source Type: news

You ’re A Covid-19 Survivor — How Long Will Your Immunity Last?
A new study reports on the duration of protective immunity in four human coronaviruses related to SARS-CoV-2. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - September 15, 2020 Category: Pharmaceuticals Authors: John Drake, Contributor Tags: Science /science Innovation /innovation Healthcare /healthcare Source Type: news

South Africa: Applicants of Covid-19 Relief Fund Urged to Register With SARS
[SAnews.gov.za] The Department of Sport, Arts and Culture says applicants for the second wave of the COVID-19 Relief Fund must be registered as taxpayers. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - September 15, 2020 Category: African Health Source Type: news

Farm animals and pandemics: nine diseases that changed the world
Covid has got experts thinking urgently about the risk of diseases passing from farmed animals to humans. We examine the major outbreaks of the past two centuriesContinue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - September 15, 2020 Category: Science Authors: Tom Levitt Tags: Environment Infectious diseases Farm animals Meat industry Food Farming Cattle BSE Bird flu Sars Swine flu Rural affairs Health World news UK news Medical research Source Type: news

COVID-19 and the Path to Immunity , JAMA (published 11th September 2020)
This Viewpoint outlines what is known about acute and long-term B-cell, antibody, and T-cell responses to SARS-CoV-2 infection and explains how each are implicated in vaccine candidates likely to be effective and durably protective again COVID-19. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 15, 2020 Category: Consumer Health News Source Type: news

Progress toward antiviral treatments for COVID-19
COVID-19 is caused by a virus known as SARS-CoV-2, which is similar in structure to two other viruses that have caused recent outbreaks: SARS-CoV, which caused an outbreak of SARS in 2003, and MERS-CoV, the cause of a 2012 outbreak of Middle East Respiratory Syndrome. (Source: World Pharma News)
Source: World Pharma News - September 15, 2020 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Tiny antibody component highly effective against SARS-COV-2 in animal studies
University of Pittsburgh School of Medicine scientists have isolated the smallest biological molecule to date that completely and specifically neutralizes the SARS-CoV-2 virus, which is the cause of COVID-19. This antibody component, which is 10 times smaller than a full-sized antibody, has been used to construct a drug - known as Ab8 - for potential use as a therapeutic and prophylactic against SARS-CoV-2. (Source: World Pharma News)
Source: World Pharma News - September 15, 2020 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Covid-19 ethics: Should we deliberately infect volunteers in the name of science? (part 1)
Would you be willing to have a dose of Sars-CoV-2 sprayed up your nose for medical research? For thousands around the world, the answer is yes. Eager volunteers have already signed up to take part in human challenge trials, where participants would be deliberately infected with the virus in order to better understand the disease, and rapidly develop a treatment or vaccine. But should such studies go ahead with a dangerous and relatively new virus?In the first of two episodes, alongside a panel of experts Ian Sample delves into some of the ethical questions of human challenge trials and asks where the balance of risks and b...
Source: Guardian Unlimited Science - September 15, 2020 Category: Science Authors: Presented by Ian Sample and produced by Madeleine Finlay Tags: Coronavirus outbreak Infectious diseases Medical research Microbiology Science Source Type: news

Arizona COVID-19 Genomics Union tracks strains of SARS-CoV-2
(The Translational Genomics Research Institute) Faculty at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, Northern Arizona University (NAU), University of Arizona (UArizona) and Arizona State University (ASU) launched the ACGU in April with the express purpose of tracking the causative agent of COVID-19, SARS-CoV-2: how it evolves and how it spreads into, within and out of Arizona. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 15, 2020 Category: Infectious Diseases Source Type: news

COVID-19 virus uses heparan sulfate to get inside cells
(University of California - San Diego) UC San Diego researchers discovered that the SARS-CoV-2 virus can't grab hold of cell receptor ACE2 without a carbohydrate called heparan sulfate, which is also found on lung cell surfaces -- disrupting that interaction with a repurposed drug may help treat COVID-19. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 15, 2020 Category: Infectious Diseases Source Type: news

NAU's Keim leads ACGU to publish findings of study tracking strains of SARS-CoV-2 in state
(Northern Arizona University) Initial findings reported by the Arizona COVID-19 Genomics Union (ACGU) suggest that following Arizona's first reported case of COVID-19 in late January, the state experienced no subsequent cases that went undetected and was COVID-free until at least 11 distinct incursions occurred between mid-February and early April. The published results appear in the scientific journal mBio. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 15, 2020 Category: Infectious Diseases Source Type: news