“ Molecular regulation of inflammation ”
Ivan Zanoni will give IIG seminar on June 5th. The primary research of the Zanoni lab is centered on the study of Pattern Recognition Receptor (PRR) signaling pathways, which initiate all immune responses in response to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). The organizing principles that govern PRR signaling are largely unknown. Dr. Zanoni seeks to understand the events that initiate protective immunity in response to infection (to bacteria, i.e., Escherichia coli, viruses, i.e., RNA viruses, i.e.: IAV and SARS-CoV-2, and to fungi, i.e., Candida albicans) and tissu...
Source: Videocast - All Events - April 26, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS- George Khoury Lecture: Coronavirus Activation and Antagonism of Interferon Signaling Pathways: from MHV to SARS-CoV-2
Coronavirus interactions with the interferon signaling response are crucial for antiviral defense especially at the early stages of infection. Murine coronavirus, MHV, has taught us a lot about the basic biology of this family of viruses as well as antagonism of innate immune response, a hallmark of coronavirus infection. Building on our MHV data, we have more recently worked with human coronaviruses. We have optimized methods for comparing human coronaviruses in a primary nasal cell air liquid interface (ALI) culture system, which models the initial site of respiratory virus infection. Common cold coronaviruses as well as...
Source: Videocast - All Events - March 6, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FDA COVID-19 SIG: Building a Technical Community of Practice in the Midst of a Pandemic: The Role of SPHERES in Genomic Surveillance for SARS-CoV-2, mpox and beyond.
Duncan MacCannell is the director for the Office of Advanced Molecular Detection (OAMD) at the Centers for Disease Control and Prevention (CDC). In this role, he helps coordinate and support the implementation and expansion of pathogen genomics, molecular epidemiology, scientific computing, and the use of innovative laboratory technologies across the public health system. This includes CDC ’ s four infectious disease centers, state and local health departments throughout the United States, and a growing global network of public health, academic and private sector institutions. Dr. MacCannell is an advocate for rapid, ope...
Source: Videocast - All Events - February 21, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Immunological mechanisms of mRNA vaccines- NIH FDA COVID-19 SIG Lecture Series
The production of antibodies (Abs) with high affinity and pathogen neutralization potential is crucial for preventing and fighting pathogen infection. To produce such Abs, na ï ve B cells are activated in response to cognate antigen and subsequently undergo rounds of somatic hypermutation and selection in germinal centers, specialized microanatomical sites in secondary lymphoid organs. This process of affinity maturation is tightly regulated by a specialized subset of CD4 T cells named T follicular helper (Tfh) cells. Our laboratory is interested in dissecting the complex biology of Tfh cells. Understanding (1) how Tfh di...
Source: Videocast - All Events - February 2, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH FDA COVID-19 SIG Lecture Series- Michela Locci Ph.D.
The production of antibodies (Abs) with high affinity and pathogen neutralization potential is crucial for preventing and fighting pathogen infection. To produce such Abs, na ï ve B cells are activated in response to cognate antigen and subsequently undergo rounds of somatic hypermutation and selection in germinal centers, specialized microanatomical sites in secondary lymphoid organs. This process of affinity maturation is tightly regulated by a specialized subset of CD4 T cells named T follicular helper (Tfh) cells. Our laboratory is interested in dissecting the complex biology of Tfh cells. Understanding (1) how Tfh di...
Source: Videocast - All Events - December 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH FDA COVID-19 SIG lecture- December 7, 2023
The COVID-19 Scientific Interest Group was created in March 2020 in response to the COVID-19 pandemic. This interest group aims to promote collaboration and facilitate the exchange of information and resources among NIH intramural scientists and their HHS colleagues concerning research on COVID-19 and SARS-CoV-2.For more information go tohttps://oir.nih.gov/sigs/covid-19-scientific-interest-groupAir date: 12/7/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 2, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FDA COVID-19 SIG Lecture: From Second Thoughts on the Germ Theory to a Gull-Blown Host Theory.
Dr. Casanova is a professor, senior attending physician, and head of the St. Giles Laboratory of Human Genetics of Infectious Diseases at The Rockefeller University, as well as a visiting professor at the Necker Hospital for Sick Children, University of Paris.The COVID-19 Scientific Interest Group (SIG) lecture series was initiated in 2020 to facilitate communication of the ongoing scientific research to understand SARS-CoV-2 and treat COVID-19. Invited speakers share the latest research on a broad range of topics, including clinical findings, therapeutics, basic biology, epidemiology, and public health research.For more i...
Source: Videocast - All Events - October 30, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
WALS- George Khoury Lecture: Coronavirus Activation and Antagonism of Innate Immune Pathways
Our lab studies murine and human coronavirus pathogenesis, including MHV, MERS-CoV and SARS-CoV. We use MHV infection of mice as a model system for the study of:acute viral encephalitischronic demyelinating diseases such as Multiple Sclerosisvirus-induced hepatitissevere acute respiratory diseases.We have the important tools of a well-developed animal model system and reverse genetic systems with which to manipulate the viral genome. We also investigate pathogenesis of human coronaviruses both the lethal MERS-CoV and SARS-CoV-2 as well as the common cold viruses OC43 and 229E and NL63. We are investigating these both in ep...
Source: Videocast - All Events - October 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH – FDA COVID SIG Lecture: Viral RNA Sensors in Human Immunity to SARS-CoV-2
This is an NIH – FDA COVID-19 SIG seminar talk. Helen Su, M.D., Ph.D., is chief of the Human Immunological Diseases Section in NIAID. LECTURE SUMMARY: Impaired type I IFN responses can lead to life-threatening COVID-19. Previous reports have established that the endosomal viral RNA sensors TLR3 and TLR7 initiate protective type I IFN responses during SARS-CoV-2 infections in humans. However, the role of the cytosolic RIG-I-like receptors (RLRs), which are more broadly expressed, has been less well studied. We investigated rare variants in the genes encoding MDA5, RIG-I, and their downstream signaling adaptor MAVS,from a ...
Source: Videocast - All Events - June 21, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinical Center Grand Rounds: SARS-Cov-2 Evolution And Potential Variant Emergence In Immunocompromised Individuals
Veronique Nussenblatt, MD, ScM, MHS
Chief, Infectious Disease Consult Service
Associate Program Director, Infectious Disease Fellowship
Director, NIH Residency Electives Program (REP)
Director, Clinical Electives Program (CEP) for Medical Students
National Institute of Allergy and Infectious Diseases, NIAID
Elodie Ghedin, PhD
Chief, Systems Genomics Section
National Institute of Allergy and Infectious Diseases, NIAIDFor more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 6/14/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - June 6, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - IL-15-induced bystander T cell activation in human viral disease.
Dr. Eui-Cheol Shin investigates mechanisms of immunopathogenesis, immunosenescence, T-cell exhaustion, and human immune monitoring. Dr. Shin and his team have extensively demonstrated the pathological significance of bystander T cell activation in human disease by studying T cell responses in patients infected with viral diseases. His group has found that pre-existing bystander memory CD8+ T cells are unexpectedly activated by cytokines (e.g., IL-15) regardless of their antigen specificity, causing liver cell damage through NKG2D-mediated cytotoxicity. In characterizing IL-15-responsive bystander T cells in the liver micro...
Source: Videocast - All Events - May 11, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH – FDA COVID SIG Lecture with Malik Peiris
In 2003, Professor Peiris and his research team discovered SARS-CoV, a novel coronavirus, as the etiological agent for SARS. He joined The University of Hong Kong in 1995, and is now Chair of Virology at the School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China. He co-directs the WHO H5 Reference Laboratory and the WHO SARS-CoV-2 reference laboratory at The University of Hong Kong. Currently, he serves on many Hong Kong and WHO advisory committees, including the WHO International Health Regulations Emergency Committee on COVID-19.
He is a clinical and public health virologis...
Source: Videocast - All Events - February 10, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH – FDA COVID SIG Lecture with Michael Diamond, WUSTL
Michael S. Diamond, MD, PhD, is the Herbert S. Gasser Professor, Departments of Medicine, Molecular Microbiology, Pathology& Immunology, WUSTL. Diamond ’ s laboratory studies the molecular basis of disease of globally emerging RNA viruses, and focuses on the interface between pathogenesis and host immunity. He identified many of the key innate and adaptive immune system components that define protection against flaviviruses, and the viral genes that antagonize this response. His laboratory made a seminal discovery by identifying a novel pathogen-associated molecular pattern (lack of 2 ′ -O methylation on the 5 ′ vira...
Source: Videocast - All Events - February 10, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH/FDA IIG Seminar - Viral reservoirs and rebound in a model of perinatal HIV infection
Dr. Chahroudi ’ s research group aims to discover mechanisms of HIV persistence, test translational cure-directed strategies, and uncover immunopathologies caused by Zika virus and SARS-CoV-2 infections using pediatric models and patient samples. Her group ’ s HIV research is centered on mother-to-child transmission of HIV. Using nonhuman primate models of pathogenic and nonpathogenic SIV infections, her group aims to elucidate the mechanisms responsible for breastfeeding transmission. Dr. Chaahroudi has found that sooty mangabeys, a natural SIV host species, rarely transmit SIV from mother to infant. A better understa...
Source: Videocast - All Events - February 8, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Identification of SARS-CoV-2 Inhibitors of Host and Viral Factors Required for Replication
This is an NIH – FDA COVID-SIG lecture with Adolfo Garcia-Sastre, Ph.D., from Mt. Sinai in New York. See the speaker's bio at https://icahn.mssm.edu/profiles/adolfo-garcia-sastre.Air date: 2/16/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 3, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
