Scientists Unlock Mystery Of Why Long COVID Causes Brain Fog (M)
Up to 10 percent of people get long COVID after being infected with the SARS-CoV2 virus. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 26, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: COVID19 subscribers-only Source Type: blogs
A potential discovery of highly fatal SARS coronavirus?
Has a highly fatal SARS coronavirus already been discovered? Maybe yes, but just its report is highly concerning. On January 4, 2024, a letter to the editor was uploaded to a preprint server which gave too few details but described a 100 percent fatal virus in genetically modified mice. The modifications made these mice similar
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A potential discovery of highly fatal SARS coronavirus? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 23, 2024 Category: General Medicine Authors: Kevin T. Kavanagh, MD Tags: Conditions COVID Infectious Disease Source Type: blogs
Senescent Cells in the Human Brain
Study of the biochemistry of the human brain is hindered by the difficulty of accessing tissue samples. Most work is conducted on post-mortem tissue rather than samples taken from a living brain (such as during surgery), and few research groups have the necessary connections to obtain these materials. Thus the development of brain organoids is important in this part of the medical research field, even given that most present organoid recipes result in a poor substitute for actual tissue. Here, researchers use post-mortem tissue and organoids to demonstrate that senescent cells are important in the aging of the brain, and i...
Source: Fight Aging! - November 23, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Enhanced mRNA Vaccine May Work Intranasally.
Researchers at MIT have developed an enhanced mRNA vaccine system that can elicit a greater immune response at lower doses. The vaccine technology is so potent that it may be useful for intranasal COVID-19 vaccines. This would have the benefit of localized immunity in the nasal mucus membranes that could kill the SARS-CoV-2 virus before it enters the body. The system includes an mRNA strand that encodes the viral spike protein, as with earlier generations of such vaccines, but in this case the strand also encodes for an immune protein called C3d. This protein typically binds to antigens, such as the spike protein, in the b...
Source: Medgadget - October 23, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Public Health covid mit SARS-CoV-2 Source Type: blogs
Lateral Flow Test for Gingivitis
Researchers at the University of Cincinnati have developed a lateral flow assay that can detect bacterial toxins from Porphyromonas gingivalis, the causative bacteria for gingivitis. The technology could make it easier and faster to identify early-stage gingivitis, which can lead to periodontitis and eventual tooth loss, as well as contributing to a variety of other diseases such as stroke and heart disease. The lateral flow assay requires a small saliva sample, and can provide results very quickly, but does require the saliva sample to be pre-treated with potato starch to deactivate salivary amylase, an enzyme that can in...
Source: Medgadget - October 19, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Dentistry Diagnostics gingivitis UofCincy Source Type: blogs
Viruses and Bats
by Gertrud U. Rey Remember the series of flashbacks in the ending of the movie “Contagion,” which reveal where the virus originated and how the pandemic started? As a tree is cut down, a colony of bats flies out of the tree to seek new shelter. While in flight over a nearby farm, one of … Viruses and Bats Read More » (Source: virology blog)
Source: virology blog - October 5, 2023 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey ACE2 bat bats contagion coronavirus emergence emerging virus furin cleavage site host range outbreak pandemic reservoir reservoir host SARS SARS-CoV SARS-CoV-2 spillover surveillance zoono Source Type: blogs
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Short Term Fasting Enhances the Immune Function of Red Blood Cells
A number of lines of research suggest that forms of calorie restriction and fasting can improve the function of the immune system. It is also noted that fasting can reduce the number of immune cells found in the circulation. The complement system is a part of the innate immune system, reacting to invading pathogens in order to rouse immune cells to action. Red blood cells play a part in the complement system, and researchers here show that fasting can improve the immune response despite a lower number of circulating white blood cells by improving the ability of red blood cells to trigger a response.
Fasting is kno...
Source: Fight Aging! - September 12, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Device for Rapid COVID-19 Breath Testing
Researchers at Washington University School of Medicine have developed a COVID-19 breathalyzer test. The technology requires someone to breathe into it just once or twice, and it can then provide an indication if the person is infected with SARS-CoV-2 in as little as one minute. The device could be very useful fo screening large numbers of people prior to access to an indoor event, for instance, or in community clinics to quickly determine if people are infected. Moreover, the technology could be adapted to detect other viruses, which may be useful for future outbreaks. The system involves blowing into a straw, which direc...
Source: Medgadget - September 7, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Public Health wustl WUSTLmed Source Type: blogs
Peptoid Oligomers Target Viral Membranes
Researchers at New York University have developed a new method to target many viruses that cause disease. For viruses with a lipid membrane, which includes many that commonly cause disease, this new technique could prove to be fatal. By targeting the lipid membrane, the approach may circumvent the treatment resistance that arises when viruses mutate to alter their surface proteins, which are the most common targets for conventional anti-viral drugs. This new approach is based on a synthetic version of antimicrobial peptides, which are naturally produced by our immune system and can target pathogens such as bacteria and vir...
Source: Medgadget - August 30, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Public Health Source Type: blogs
Fight Aging! Newsletter, July 10th 2023
In conclusion, the examination of the GBA can aid in understanding the etiology and development of NDs, which may benefit the improvement of clinical treatments for these disorders and ND interventions. This review indicates existing knowledge about the involvement of microbiota present in the gut in NDs and potential treatment options.
The Aging of the Enteric Nervous System
https://www.fightaging.org/archives/2023/07/the-aging-of-the-enteric-nervous-system/
The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome ...
Source: Fight Aging! - July 9, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Age-Associated B Cells Correlate with Impaired Immune Response
Age-associated B cells are one of a number of dysfunctional or maladaptive immune cell subpopulations that appear in increasing numbers in later late, and which likely impair the many functions of the immune system by their presence. Clearing all B cells rather than trying to selectively clear age-associated B cells is a viable proposition, as the B cell population regenerates quite rapidly following clearance, and the new cells lack the age-associated B cell phenotype. This has been demonstrated in animal models, but has yet to make it to the clinic as a treatment to improve the aged immune system.
Age-associated...
Source: Fight Aging! - July 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Current resources about COVID-19
(Last updated 19th June 2023)IntroductionDuring lockdown I maintained a set of blogposts linking to resources about COVID. I have not updated those for some time, and have now decided that they are no longer needed. I have added the word " Archived " to the start of each page title, and tried to make it clear that they are no longer updated. Of course, COVID-19 has not gone away, and has become one of the infectious diseases that is with us always. So, I think although those older posts are no longer useful, a current list of resources might be. So, here is a shorter...
Source: Browsing - June 19, 2023 Category: Databases & Libraries Tags: COVID-19 Source Type: blogs
Lab-Created Mini Lungs to Study Respiratory Infections
Researchers at Rockefeller University have developed a cell culture platform in which to grow ‘lung buds’ from human embryonic stem cells. The tiny structures are similar to the lung buds that form during fetal development, and they contain tiny airways and alveoli. The researchers create the structures in a bio-reactor style device that is furnished with microfluidic chips in which the lung buds grow. The team developed a cocktail of growth factors that can stimulate the embryonic cells to differentiate into the lung buds, and they hope to use the system to test how respiratory infections behave and to discover new tr...
Source: Medgadget - June 19, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Pathology Public Health RockefellerUniv Source Type: blogs
Is the Bank Secrecy Act Effective at Stopping Crime? No One Knows
ConclusionLater at the oversight hearing, RepresentativeWarren Davidson (R ‑OH) said,Give us some metrics. …Give us the evidence.…How do you measure the effectiveness? …Show me a case where what you collected resulted in a solved crime.…I’m looking for cause and effect. If you want to keep spying on American citizens, you’re going to have to show why.Between therequests from the public andcongressional inquiries, FinCEN is certainly aware of the pressing need to supply statistics on the effectiveness of the financial surveillance it oversees. At this point, however, it ’s clear that Congress needs to doub...
Source: Cato-at-liberty - June 2, 2023 Category: American Health Authors: Nicholas Anthony Source Type: blogs
