What's new in midwifery - research - 25th May 2022
Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy (Nature Communications, UK based researchers)(US) Agency for Healthcare Research and Quality,Maternal and child outcomes associated with the Special Supplemental Nutrition Program for Women, Infants and Children (WIC). Comparative Effectiveness Review no. 253. Association of SARS-COV-2 infection during pregnancy with maternal and perinatal outcomes (JAMA)Acknowledgement for all three: McMaster Evidence Alerts (Source: Browsing)
Source: Browsing - May 25, 2022 Category: Databases & Libraries Tags: midwifery Source Type: blogs
Fight Aging! Newsletter, May 23rd 2022
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan.
Naked Mole-Rat Skin Shows Fewer Signs of Aging
https://www.fightaging.org/archives/2022/05/naked-mole-rat-skin-shows-fewer-signs-of-aging/
Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem ...
Source: Fight Aging! - May 22, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
TWiV 902: Autoantibodies drive severe COVID-19
TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19. (Source: virology blog)
Source: virology blog - May 22, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology autoantibodies coronavirus COVID-19 feces interferon monkeypox pandemic SARS-CoV-2 smallpox viral viruses Source Type: blogs
TWiV 901: COVID-19 clinical update #115 with Dr. Daniel Griffin
In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding. (Source: virology blog)
Source: virology blog - May 21, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody Omicron pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
Pathogenic Viruses Have Evolved to Provoke Cellular Senescence
We present a "decentralized" information processing model that conceptualizes neurodegeneration as a systemic illness, triggered by cytoskeletal pathology. We also discuss strategies for reversing cell-cell fusion, including, TMEM16F inhibitors, calcium channel blockers, senolytics, and tubulin stabilizing agents. Finally, going beyond neurodegeneration, we examine the potential benefit of harnessing fusion as a therapeutic strategy in regenerative medicine.
Link: https://doi.org/10.3389/fcimb.2022.845580 (Source: Fight Aging!)
Source: Fight Aging! - May 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Videos about using the UCSC Genome Browser for analysis of SarsCOV2
These look pretty useful and thought I would post here. Text is from the UCSC Youtube channelThis 5-part video series is for virologists and public health researchers interested in leveraging the UCSC Genome Browser and web interface to UShER (Ultrafast Sample placement on Existing tRees). These tools are a ' one-stop shop ' to understand SARS-CoV-2 through genome annotations as well as track variants by placing your samples in a phylogenetic tree with millions of other SARS-CoV-2 sequences. Use the SARS-CoV-2 Genome Browser:http://bit.ly/sarscov2browser Visit our SARS-CoV-2 Genome Browser and UShER quick start page ...
Source: The Tree of Life - May 16, 2022 Category: Microbiology Source Type: blogs
TWiV 900: Burning down the mouse
TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Click arrow to playDownload TWiV 900 (65 MB .mp3, 108 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - May 15, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology COVID-19 inflammation inflammosome macrophage pandemic SARS-CoV-2 severe COVID viral virus Source Type: blogs
COVID-Related Skin Injuries
Thankfully the worst of the COVID-19 pandemic is over, but there is no doubt that the public health crisis brought new challenges to the wound care world. There has been profound impact upon caregivers and patients, including the epidemiology of skin lesions such as pressure injuries. The reverberations of the pandemic are still lingering, and this post will call attention to major concerns.
Impact of COVID-19 on Pressure Injury Epidemiology
The impact of SARS-CoV-2 on the occurrence of pressure injuries is substantial. Patients with severe respiratory disease and extended ICU admissions while on life support such as v...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - May 3, 2022 Category: Geriatrics Authors: Jeffrey M Levine Tags: Featured Medical Articles Geriatric Medicine Pressure Injuries & Wound Care bedsores coronavirus COVID COVID-19 decubiti decubitus ulcer Healthcare Quality Improving Medical Care pandemic pressure sore pressure sores pressure u Source Type: blogs
TWiV 896: Memory B cells, the way we were
TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost. Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld Click arrow to playDownload TWiV 896 (65 MB .mp3, 108 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at […] (Source: virology blog)
Source: virology blog - May 1, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antibody climate change COVID-19 memory B cell pandemic SARS-CoV-2 variant of concern viral virus viruses zoonosis Source Type: blogs
TWiV 895: COVID-19 clinical update #112 with Dr. Daniel Griffin
In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation. (Source: virology blog)
Source: virology blog - April 30, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody Omicron pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
TWiV 894: Dinner with the TMPRSS family
TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection. (Source: virology blog)
Source: virology blog - April 29, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology adenovirus antiviral drug coronavirus COVID-19 hepatitis pandemic peptidomimetic SARS-CoV-2 Tmprss2 viruses Source Type: blogs
Spray Blocks SARS-CoV-2 Entry into Nasal Cells
Researchers at the University of British Columbia, and collaborators, created a nasal spray that can block the entry of SARS-CoV-2 into cells in the nasal cavity, potentially offering protection and treatment for COVID-19. Excitingly, in lab tests, the spray appears to work against all known variants of the virus, including the Omicron variant, which shows some resistance to our existing vaccines.
The spray dramatically increased survival in a mouse model of severe COVID-19, highlighting its potential as both a treatment and a prophylactic. The spray contains a drug that inhibits an enzyme in the nasal cells that is in...
Source: Medgadget - April 18, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Public Health Source Type: blogs
TWiV 890: Looking into a booster crystal ball
This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response. (Source: virology blog)
Source: virology blog - April 18, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antibody coronavirus COVID-19 pandemic SARS-CoV-2 T cells vaccine viral viruses Source Type: blogs
TWiV 889: COVID-19 clinical update #110 with Dr. Daniel Griffin
outbreaks, viral load in vaccinated and unvaccinated individuals, predictive capacity of symptoms in children, comparison of antigen tests, incidence of myocarditis after vaccination, steroids during replication phase, Paxlovid efficacy and safety, fluvoxamine, sabizabutin, colchicine, and prevalence of infection in Africa. (Source: virology blog)
Source: virology blog - April 16, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
TWiV 888: Molnupiravir with Richard Plemper
Richard joins TWiV to discuss the SARS-CoV-2 antiviral drug Molnupiravir , including how it was discovered, its mechanism of action, whether it is a mutagen for cells, and the future of drugs for treatment of COVID-19. (Source: virology blog)
Source: virology blog - April 14, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral drug coronavirus COVID-19 Molnupiravir remdesivir ribavirin SARS-CoV-2 viruses Source Type: blogs
