Omicron (B.1.1529) COVID variant
Last updated 1245 UK time 17th December 2021. Items added that day are flagged NEW.Research literature and scientific informationPubMedUPDATED -Both strategies amended 13th December to find Omikron.Less sensitive strategy (finding 28 items as of 13th December)More sensitive strategy - to find the two Omicron lineages, BA.1 and BA.2 as well (finds 67 items as of 13th December, but including any COVID work from UK postcodes BA1 and BA2...)PubMed COVID-19 Clinical Query (finds one relevant item as of 13th December)PreprintsCOVID preprints from medRxiv and bioRxiv (sorted by date so newest first).Twit...
Source: Browsing - November 27, 2021 Category: Databases & Libraries Tags: coronavirus COVID-19 Source Type: blogs
Omicron (B.1.1529 COVID variant )
Last updated 1430 UK time 24th December 2021. Items added that day flagged NEW.Research literature and scientific informationPubMedLess sensitive strategy (finds 100 items as of 21st December - found 28 on 13th)More sensitive strategy - same as strategy above but have added Omicron lineages, BA.1 and BA.2(finds 140 items as of 21st December - found 67 on 13th. Note: results include work on any aspect of COVID from UK postcodes BA1 and BA2).PubMed COVID-19 Clinical Query Select aspect (diagnosis, treatment, etc.) from the drop down boxPreprintsCOVID preprints from medRxiv and bioRxiv (sorted...
Source: Browsing - November 27, 2021 Category: Databases & Libraries Tags: coronavirus COVID-19 Source Type: blogs
TWiV 833: Grand theft kinesin
TWiV reviews Michael Worobey’s dissection of the early COVID-19 cases in Wuhan, and the discovery that herpesviruses assimilate cellular kinesin to produce motorized virus particles. Click arrow to playDownload TWiV 833 (77 MB .mp3, 128 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 25, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology COVID-19 herpesvirus Huanan Market kinesin motor microtubule pandemic SARS-CoV-2 viral viruses Wuhan Source Type: blogs
TWiV 832: Heavy metal flu fighters
TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine. Click arrow to playDownload TWiV 832 (77 MB .mp3, 128 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 21, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology adenovirus vector adjuvant correlate of protection Covaxin COVID-19 inactivated vaccine influenza influenza oral vaccine mass cytometry pandemic SARS-CoV-2 smallpox vaccine efficacy vaccinia virus viral Source Type: blogs
TWiV 831: COVID-19 clinical update #89 with Dr. Daniel Griffin
In COVID-19 clinical update #89, Dr. Griffin reviews upcoming meeting on FDA emergency use authorization for molnupiravir, 25% of US cases in children, reinfection associates with presence of antibodies, national surveillance for acute flaccid myelitis in the US, and monoclonal antibody treatment of infection in vaccinated, high-risk individuals. Click arrow to playDownload TWiV 831 (20 MB .mp3, […] (Source: virology blog)
Source: virology blog - November 21, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
What's new in midwifery - research - 19th November 2021
Some recent research and systematic reviews. You may need librarian (if you have one to hand) intervention to get full text.Does walking reduce postpartum depression symptoms (systematic review, Journal of Women ' s Health) Fetal movement awareness and reducing stillbirths (RCT, BJOG)Induction of labour at 41 (and expectant management) vs 42 weeks (cost effectiveness analysis, BJOG) SARS-CoV-2 infection in pregnancy and pre eclampsia (systematic review, AJOG)Tissue adhesives in perineal trauma during childbirth (systematic review in Journal of Clinical Nursing)Tranexamic acid f...
Source: Browsing - November 19, 2021 Category: Databases & Libraries Tags: midwifery Source Type: blogs
TWiV 830: A culture of resistance
TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitrowould not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the […] (Source: virology blog)
Source: virology blog - November 18, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology coronavirus COVID-19 pandemic remdesivir resistance SARS-CoV-2 V(D)J recombination variant of concern viral viruses Source Type: blogs
TWiV 829: Antiviral and cytotoxically empowered for COVID-19
A TWiV duo reviews how SARS-CoV-2 attacks the olfactory mucosa but spares the olfactory bulb, vaccination with BNT162b2 induces virus-specific stem cell memory T cells, and development of an oral protease inhibitor for the treatment of COVID-19. Click arrow to playDownload TWiV 829 (67 MB .mp3, 112 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 14, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology anosmia coronavirus COVID-19 memory T cell olfactory epithelium pandemic paxlovia SARS-CoV-2 viral viruses Source Type: blogs
TWiV 828: COVID-19 clinical update #88 with Dr. Daniel Griffin
In COVID-19 clinical update #88, Dr. Griffin covers vaccine protection among US veterans, absence of long COVID in vaccinated who are infected, single dose of REGEN-COV monoclonal antibody cocktail provides long term protection, and Pfizer protease inhibitor Paxlovid is 89% effective in preventing hospitalization or death. Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 13, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
Pills for COVID-19
Multiple vaccines have been developed that have made substantial contributions to controlling the COVID-19 pandemic, but where are the antivirals? Only repurposed drugs have been used and not with much success. That situation seems about to change with the authorization of drugs that target the RNA polymerase (Molnupiravir) and a viral protease (Paxlovid). Molnupiravir is […] (Source: virology blog)
Source: virology blog - November 12, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antiviral coronavirus COVID-19 Molnupiravir Paxlovid protease inhibitor SARS-CoV-2 viruses Source Type: blogs
Medgadget Reviews the Sleep Number i10 360 Smart Bed
Conclusion
In the conclusion for our review ten years ago, we posed the question about whether such an expensive bed was worth it. Let’s be real: Sleep Number beds are not cheap. Our bed configuration for just the mattress alone was $4599. Even with the inclusion of Sleep IQ, you still may first want to consider other solutions to help monitor and improve your sleep. But we felt that the beds have improved much: the materials and appearance are more modern and advanced, and the added electronics make it as close as you can get to a smart bed. We just wish it could integrate with smart home systems; with so many li...
Source: Medgadget - November 10, 2021 Category: Medical Devices Authors: Scott Jung Tags: etc. Exclusive Orthopedic Surgery Pain Management bam labs sleep number sleepnumber Source Type: blogs
Chip for Investigation of Coronavirus Intestinal Infection
This study demonstrates that we can explore complex interactions between cells, pathogens, and drugs in the human intestine using our Intestine Chip as a preclinical model,” said Don Ingber, a researcher involved in the study, via a press release. “We hope it proves useful in the ongoing effort to better understand the effects of SARS-CoV-2 and to identify drugs that could be used to combat future viral pandemics.”
Study in Frontiers in Pharmacology: Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip
Flashbacks: Intestine Chip to Study Human-Microbiome Interact...
Source: Medgadget - November 10, 2021 Category: Medical Devices Authors: Conn Hastings Tags: GI Medicine Public Health Source Type: blogs
Fifty Years of the Protein Data Bank!
Protein Data Bank’s 50 years logo. Credit: PDB website.
The Protein Data Bank (PDB), established in 1971, is the single global repository for 3D structural data of proteins, DNA, RNA, and even complexes these biological molecules form with drugs or other small molecules. More than 1 million people—including researchers, medical professionals, educators, and students—use the PDB each year. NIGMS and other parts of NIH have helped fund this free digital resource since 1978.
Simulate Scientific Discovery & Learn the Steps to Unlocking Molecular Structures
Gameboard setup for PDB50: The Game. Credit: P...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 10, 2021 Category: Research Authors: Rachel Crowley Tags: Chemistry, Biochemistry and Pharmacology Molecular Structures Tools and Techniques Proteins Source Type: blogs
