Paul and the Mosquitos
From the authors of Paul Has Measles and Paul Stays Home comes Paul and the Mosquitos, an illustrated book for children about mosquito-borne diseases. (Source: virology blog)
Source: virology blog - July 30, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Chikungunya dengue fever malaria mosquito mosquito borne disease viral virus viruses yellow fever Source Type: blogs

T cells will save us from COVID-19, part 3
In the two previous installments (one, two) of what has now become my praise of T cells, I explained that the SARS-CoV-2 protein sequences recognized by T cells do not change, likely explaining why vaccines prevent serious disease and death caused by any variant. Today I will explain that virus-specific T cells appear a week […] (Source: virology blog)
Source: virology blog - July 30, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology antibody B cell coronavirus COVID-19 pandemic SARS-CoV-2 T cell vaccine viral viruses Source Type: blogs

Trial By Error: Tack and I Write to Psych Medicine; Struthers Writes to Medical Research Council
By David Tuller, DrPH A recent study of cognitive behavior therapy (CBT) for patients with “persistent physical symptoms” (PPS), a category alsocalled “medically unexplained symptoms,” reported null results for its primary outcome. These null results were not mentioned in the conclusion of the abstract, which instead focused on minimal reported benefits for a minority of […] (Source: virology blog)
Source: virology blog - July 24, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized cochrane Medically unexplained symptoms Michiel Tack persistent physical symptoms PPS struthers Source Type: blogs

Trial By Error: CBT Model of Medically Unexplained Symptoms, Explained; CBT Trial for Q-Fever Fatigue
By David Tuller, DrPH As I have recently written, four major clinical trials of CBT for so-called MUS have documented the opposite of what the investigators hoped to prove. In fact, the evidence from this research suggests that CBT is not an effective treatment for these conditions. That hasn’t stopped these investigators from claiming otherwise, […] (Source: virology blog)
Source: virology blog - July 22, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized CBT MUS Q-fever Qure Source Type: blogs

Trial By Error: Medical Societies and new Komaroff-Lipkin Paper Highlight Long COVID and ME/CFS Links
By David Tuller, DrPH While some medical professionals argue that prolonged non-specific symptoms after acute COVID-19 are psychogenic and that “Long COVID” as a presumed clinical entity was concocted by a cabal of queers and feminists, others are getting on with efforts to disseminate more appropriate information to their colleagues. These efforts often involve drawing […] (Source: virology blog)
Source: virology blog - July 20, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Komaroff lipkin Long Covid Medical Board of California Nina Muirhead Royal Society of Physicians Source Type: blogs

A whale of a virus story
The ancestors of cetaceans (whales, dolphins, and porpoises) moved from land to the sea over 50 million years ago. Many viruses infect cetaceans, but how they evolved during the shift from land to sea is unknown. Fossilized retroviral genomes integrated into cetacean DNA provide insight into this question. The retroviral reproduction cycle involves the conversion […] (Source: virology blog)
Source: virology blog - July 16, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information cetacean endogenous retrovirus ERV phylogenetic analysis viral viruses Source Type: blogs

Trial By Error: Some Lightning Process Updates
By David Tuller, DrPH A Final Round in Norway Lightning Process supporters got some bad news recently when a Norwegian national research ethics panel rejected a proposed study because it was poorly designed and fraught with conflicts of interest, as I wrote about here. But that wasn’t the end of the drama. Although the ethics […] (Source: virology blog)
Source: virology blog - July 13, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Crawley Lightning Process norway phil parker Source Type: blogs

Evolution of a bacterial protein into a virus-like, RNA binding capsid
Starting with a bacterial protein, directed evolution in the laboratory has been used to produce a virus-like capsid that binds and protects RNA. This finding has implications for the origins of viruses. One view of the evolution of life is that viruses were present even before the first cells in the form of self-replicating molecules. […] (Source: virology blog)
Source: virology blog - July 9, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information capsid directed evolution primordial replicator RNA packaging RNA world viral virus viruses Source Type: blogs

Trial By Error: Professor Steven Lubet on Misogyny, Homophobia and Long COVID Denialism
By David Tuller, DrPH My friend and colleague Steven Lubet is a professor of law at Northwestern University. He and I have collaborated on a number of articles, including a response to Professor Michael Sharpe’s views on so-called “medically unexplained symptoms” in the journal Medical Humanities and a piece on links between ME/CFS and Long […] (Source: virology blog)
Source: virology blog - July 6, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Professor White & Colleagues “ Regret ” Ignoring Null Results in GETSET Trial Follow-Up
By David Tuller, DrPH Last week, I wrote about the correction made to the “Highlights” section of the paper reporting the long-term follow-up results for the GETSET trial. (The trial was conducted by Professor Peter White, one of the three lead PACE investigators, and colleagues.)  I noted that this correction was not indicated or identified—a […] (Source: virology blog)
Source: virology blog - July 5, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized correction GETSET Journal of Psychosomatic Research Peter White Source Type: blogs

Trial By Error: Quartet of Trials Reveals Limitations of CBT for “ Medically Unexplained Symptoms ”
By David Tuller, DrPH A year ago, I wrote a post about how the biopsychosocial ideological brigades had completed a trifecta of major studies that investigated cognitive behavior therapy for a variety of so-called “medically unexplained symptoms” (MUS). As a group, the studies demonstrated the overall ineffectiveness of CBT as a treatment for this category […] (Source: virology blog)
Source: virology blog - July 3, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized CODES PACE Source Type: blogs

Dynamics of SARS-CoV-2 Vaccine-Induced Antibody Immunity
It is slowly becoming clear that the immunity induced by SARS-CoV-2 vaccination is of overall better quality than that induced by COVID-19. (Source: virology blog)
Source: virology blog - July 1, 2021 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey ACE2 b cells COVID-19 β-coronaviruses monoclonal antibody N-terminal domain natural infection neutralizing antibody plasmablast polyclonal antibodies RBD SARS-CoV-2 SARS-CoV-2 variant spike protein Source Type: blogs

Trial By Error: Journal Corrects “ Highlights ” of GETSET Paper; A Letter about Prof White ’ s GET Safety Paper
By David Tuller, DrPH I have pressed the Journal of Psychosomatic Research to correct a recent paper—”Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial.” The senior author is Professor Peter White. Now the journal has published a revised “Highlights” section of the paper that accurately […] (Source: virology blog)
Source: virology blog - June 30, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized GETSET Journal of Psychosomatic Research Peter White Source Type: blogs

Trial By Error: Lowenstein ’ s Guardian Opinion; Eliot Smith ’ s Post-NICE View; Tack ’ s Take on Blinding Study
By David Tuller, DrPH The Guardian has published a lot of nonsense about Long COVID and has provided a platform for people who argue that robust manly thoughts are the path to recovery. Of course, it also published George Monbiot’s powerful columns on the topic, including his rebuttal of silly accusations that he was triggering […] (Source: virology blog)
Source: virology blog - June 25, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized blinding Guardian Long Covid lowenstein Michiel Tack NICE valerie eliot smith Source Type: blogs

Trial By Error: Did the IBS Trial Really Show that Web-Based CBT Offered Significant Clinical Effectiveness?
By David Tuller, DrPH I wrote some posts last year about the ACTIB trial–a major study of telephone-delivered and web-delivered cognitive behavior therapy (TCBT and WCBT) for irritable bowel syndrome (IBS). Contrary to how the results have been framed by those with reputational and financial interests in promoting them, the study demonstrated that WCBT did […] (Source: virology blog)
Source: virology blog - June 24, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized IBS mahana MCID Source Type: blogs

Trial By Error: Null Outcomes Presented as Success in Yet Another CBT Trial from Prof Trudie Chalder
By David Tuller, DrPH Trudie Chalder, a professor of cognitive behavior therapy (CBT) at King’s College London, has recently published yet another high-profile paper: the main results for “efficacy” from a trial of CBT for patients with so-called “persistent physical symptoms” (PPS) in secondary care. As usual with this group of investigators, things haven’t turned […] (Source: virology blog)
Source: virology blog - June 19, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized CBT chalder MUS PPS PRINCE Source Type: blogs

The remarkable diversity of bat coronaviruses
All human viruses, including SARS-CoV-2, arose from spillovers from other animals. Results of a recent study of bat samples collected in a small region of Yunnan Province, China revealed additional close relatives of SARS-CoV-2 and SARS-CoV. After the identification of SARS-CoV-2 in early 2020, wildlife sampling and retrospective genome sequencing revealed highly related viruses in […] (Source: virology blog)
Source: virology blog - June 18, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information coronavirus COVID-19 Rhinolophus bat SARS-CoV-2 viral viruses wildlife sampling zoonosis Source Type: blogs

Trial By Error: #MEAction ’ s Chronic Illness Survey; Patients ’ Research Informs CDC ’ s Long-COVID Advice
By David Tuller, DrPH New survey to assess links between chronic conditions Jaime Seltzer, #MEAction’s Director of Scientific & Medical Outreach, has been pretty busy lately. This week, she appeared on a panel at the World Health Organization’s Long COVID webinar—alongside no less than the distinguished and always affable Professor Sir Simon Wessely. Seltzer has […] (Source: virology blog)
Source: virology blog - June 16, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Hannah Davis Jamie Seltzer Mady Hornig MEAction Source Type: blogs

Holiday travel explains spread of a SARS-CoV-2 variant
The emergence and spread throughout Europe of a SARS-CoV-2 variant, 20E (EU1) in the summer of 2020 illustrates how a virus may become dominant not by increased transmissibility but through travel and lack of effective containment and screening. The SARS-CoV-2 variant 20E (EU1) emerged in Spain in the summer of 2020 and spread to multiple […] (Source: virology blog)
Source: virology blog - June 11, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology antibody coronavirus COVID-19 fitness advantage pandemic SARS-CoV-2 transmission variant viral viruses Source Type: blogs

Trial By Error: More Disinformation from Professor White in Journal of Psychosomatic Research
By David Tuller, DrPH The Journal of Psychosomatic Research seems to be suffering from some sort of identity crisis. Earlier this year, the editor and his two immediate predecessors published an admirable editorial in which they noted the serious risk of bias in subjective outcomes in studies that are not rigorously blinded. Yet the journal’s […] (Source: virology blog)
Source: virology blog - June 10, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized GETSET Journal of Psychosomatic Research Peter White Source Type: blogs

Trial By Error: Norway Rejects New Clinical Trial of Woo-Woo Lightning Process
By David Tuller, DrPH In a welcome display of scientific acumen, Norwegian research ethics authorities have rejected a proposed study of the woo-woo called the Lightning Process as a treatment for ME/CFS. Since Norway generally appears to be a hotbed of biopsychosocial thinking, this excellent decision is a bit of a surprise. It follows a […] (Source: virology blog)
Source: virology blog - June 7, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

When Viruses Collide with Parasitic Worms
Infection with some parasitic worms may lead to an impaired immune response against pathogenic infections by other parasites, bacteria, and some viruses. (Source: virology blog)
Source: virology blog - June 3, 2021 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey flavivirus Heligmosomoides polygyrus bakeri helminth Hpb IL-4 parasites STAT6 succinate tuft cells type 2 immune responses West Nile virus WNV worms Source Type: blogs

T cells will save us from COVID-19, part two
T cells are the other arm of the adaptive immune response (in addition to B cells) that are essential for clearing virus infections. Most studies of immunity to SARS-CoV-2 infection have focused on antibodies and their ability to neutralize virus infection. The observation that variants of concern are less effectively neutralized by antibodies against ancestral […] (Source: virology blog)
Source: virology blog - May 28, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antibody B cell epitope COVID-19 cytotoxic T cell SARS-CoV-2 t cell epitope vaccine variants of concern viral virus viruses Source Type: blogs

Novel human coronaviruses from pigs and dogs
Recently isolated coronaviruses from humans in Haiti and Malaysia appear to have originated in pigs and dogs. (Source: virology blog)
Source: virology blog - May 20, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information coronavirus COVID-19 dog coronavirus feline coronavirus pandemic pig coronavirus spillover viral viruses zoonosis Source Type: blogs

Trial By Error: Journal Editorial Calls for Caution in Exercise-Based Rehab Programs for Long COVID
By David Tuller, DrPH The Journal of Orthopaedic & Sports Physical Therapy recently published an editorial called  “Humility and Acceptance: Working Within Our Limits With Long COVID and Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome.” The editorial emerged from a collaboration between rehabilitation specialists and patients, mostly from Canada. It confronts the conundrum of whether those experiencing […] (Source: virology blog)
Source: virology blog - May 15, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Journal of Orthopaedic & Sports Physical Therapy Long Covid Simon Decary Source Type: blogs

A genetically stable attenuated poliovirus vaccine
Eradication of poliomyelitis appears to be on track: types 2 and 3 polioviruses have been declared eradicated, and in the past 12 months there have been just 338 cases of type 1 polio in Afghanistan and Pakistan. But there have also been 491 cases of polio caused by the type 2 Sabin vaccine. The development […] (Source: virology blog)
Source: virology blog - May 14, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information attenuated vaccine genetic stability neurovirulence OPV poliovirus recombination reversion Sabin viral viruses Source Type: blogs

Trial By Error: More Letters about Professor Anthony David ’ s Mis-Citations of Key Study on Costs of MUS
By David Tuller, DrPH I have been in correspondence with the journal Psychological Medicine in my efforts to get it to correct an undisputed factual era related to the cost of so-called “medically unexplained symptoms” (MUS). After three weeks, the journal’s co-editor-in-chief, Professor Robin Murray, finally alerted me on May 4th that the authors “have […] (Source: virology blog)
Source: virology blog - May 12, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Anthony David Bermingham MUS Psychological Medicine Source Type: blogs

Trial By Error: My Letters to Psychosomatics Journal About Prof White ’ s Misleading GETSET Paper
By David Tuller, DrPH In early April, I wrote about a study published in the Journal of Psychosomatic Research—a one-year follow-up of the GETSET trial of self-help graded exercise therapy for ME/CFS. The investigators had previously reported short-term benefits for the intervention. In this new paper, despite no benefits of the intervention over regular care, […] (Source: virology blog)
Source: virology blog - May 7, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized GETSET Source Type: blogs

Early Immune Responses to Herpes Simplex Virus Type I Infection
Early interactions of herpes simplex virus type 1 with the immune system involve both Langerhans cells and a newly characterized dendritic cell. Understanding the dynamics of these initial interactions of the virus with cells of the immune system may result in better strategies for HSV-1/-2 vaccines. (Source: virology blog)
Source: virology blog - May 6, 2021 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey actin cholesterol dendritic cell herpes herpes simplex virus herpes simplex virus 1 HSV-1 infection Langerhans cell macrophage receptor-mediated endocytosis replication Source Type: blogs

Trial By Error: In Guardian Column, Professor Pariante Parrots Standard Biopsychosocial Nonsense
By David Tuller, DrPH On Tuesday (four days ago), The Guardian published an opinion piece from Professor Carmine Pariante titled “Long Covid is very far from ‘all in the mind’–but psychology can still help us to treat it.” The article is the latest from a member of the biopsychosocial ideological brigades to demonstrate what has […] (Source: virology blog)
Source: virology blog - May 1, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Guardian King's College London monbiot Pariante Source Type: blogs

Defective genomes modulate respiratory syncytial virus pathogenesis
During viral replication, defective genomes may arise that lack essential sequences. These so-called defective genomes cannot replicate unless they are in the same cell as a helper virus. Defective genomes play a role in modulating pathogenesis of respiratory syncytial virus in humans. Copy-back defective viral genomes (cbDVGs) of RSV arise when the viral RNA polymerase […] (Source: virology blog)
Source: virology blog - April 30, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology copyback defective viral genome cytokine defective interfering particle pathogenesis respiratory syncytial virus viruses Source Type: blogs

Trial By Error: Professor David ’ s Third Mis-Citation of Seminal Study of “ Medically Unexplained Symptoms ”
By David Tuller, DrPH *April is crowdfunding month at Berkeley. I conduct this project as a senior fellow in public health and journalism at the university’s Center for Global Public Health. If you would like to support the project with a donation to Berkeley (tax-deductible for US taxpayers), here’s the place: https://crowdfund.berkeley.edu/project/25504 I have recently blogged […] (Source: virology blog)
Source: virology blog - April 26, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Anthony David Bermingham MUS Source Type: blogs

Trial By Errors: Why Have Experts in MUS Spent Ten Years Mis-Citing a Study about Costs to the NHS?
By David Tuller, DrPH What does it mean that the top investigators in a field of research have collectively and consistently misrepresented a seminal figure in their purported domain of expertise? I’m talking about all those who present themselves as authorities on the topic of so-called “medically unexplained symptoms” (MUS) but have found it difficult […] (Source: virology blog)
Source: virology blog - April 23, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

SARS-CoV-2 variants arise during individual infections
Early in the COVID-19 pandemic, SARS-CoV-2 genome variation appeared to be low, with an average of 10 base differences in the 30,000 base genome between any two isolates. Late in 2020, as many more people were infected, variants were isolated that had more changes than previously seen. A study of variation at the genome level […] (Source: virology blog)
Source: virology blog - April 23, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology antibody COVID-19 SARS-CoV-2 selection pressure variant viral virus viruses Source Type: blogs

Trial By Error: More on the Lightning Process and the Science Media Centre ’ s Collusion With UK Journalists
By David Tuller, DrPH *April is crowdfunding month at Berkeley. I conduct this project as a senior fellow in public health and journalism at the university’s Center for Global Public Health. If you would like to support the project with a donation to Berkeley (tax-deductible for US taxpayers), here’s the place: https://crowdfund.berkeley.edu/project/25504 My story on the […] (Source: virology blog)
Source: virology blog - April 22, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Esther Crawley Kate Kelland Lightning Process science media centre Tom Feilden Source Type: blogs

Trial By Error: Do the “ Vast Majority ” of Lightning Process Participants Achieve “ Lasting Change ” ?
By David Tuller, DrPH Coda Story is an excellent news organization focused on international stories related to the misuse of science and technology, among other topics. Today, it published a piece of mine about the training program called the Lightning Process. Sites devoted to the Lightning Process are full of tales of recovery from prolonged […] (Source: virology blog)
Source: virology blog - April 21, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Coda Lightning Process Phil Parer Source Type: blogs

Trial By Error: Northwestern Law Professor Steven Lubet Corresponds with McMaster U. About That WSJ Op-Ed
By David Tuller, DrPH A recent Wall Street Journal opinion piece accused an apparently powerful “queer feminist wellness collective” of causing an international wave of mental illness, which is being expressed as reports of persistent disabling symptoms after an acute bout of COVID-19. The article was written by a psychiatry resident at Canada’s McMaster University […] (Source: virology blog)
Source: virology blog - April 19, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Letter to Lancet Editor Demanding Independent Investigation of PACE (Reprise from 2018)
By David Tuller, DrPH *April is crowdfunding month at Berkeley. I conduct this project as a senior fellow in public health and journalism at the university’s Center for Global Public Health. If you would like to support the project with a donation to Berkeley (tax-deductible for US taxpayers), here’s the place: https://crowdfund.berkeley.edu/project/25504 In August, 2018, I […] (Source: virology blog)
Source: virology blog - April 18, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized letter to Lancet PACE Source Type: blogs

Trial By Error: My Letter to Professor Anthony David Asks Why MUS Experts Keep Misquoting a Major Study
By David Tuller, DrPH Earlier this week, I wrote to the journal Psychological Medicine about a significant mistake in a paper on functional neurological disorders. The mistake involved a misquotation of Bermingham et al, a key 2010 analysis of the National Health Service costs associated with care for working-age people found to be “somatising.” One […] (Source: virology blog)
Source: virology blog - April 17, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: PACE Team ’s Work for Insurance Companies Is “Not Related” to PACE. Really? (Reprise)
By David Tuller, DrPH When I first investigated the PACE trail in 2015, one of the features most shocking to me was the investigators’ blatant violation of a core human rights document that they had promised in their protocol to adhere to. That violation of the Declaration of Helsinki involved their failure to tell study […] (Source: virology blog)
Source: virology blog - April 17, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

SARS-CoV-2 variant B.1.1.7 is not more virulent
When the B.1.1.7 variant of SARS-CoV-2 was first detected in the UK in December 2020 it was accompanied by unsubstantiated claims of increased transmissibility and virulence. The results of a hospital-based study in London reveals no association of the variant with severe disease in this cohort. In a note published by NERVTAG on 21 January […] (Source: virology blog)
Source: virology blog - April 16, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Commentary B.1.1.7 coronavirus COVID-19 pandemic SARS-CoV-2 variant of concern viral viruses Source Type: blogs

Trial By Error: The World According to Sharpe
*April is crowdfunding month at Berkeley. I conduct this project as a senior fellow in public health and journalism at the university’s Center for Global Public Health. If you would like to support the project with a donation to Berkeley (tax-deductible for US taxpayers), here’s the place: https://crowdfund.berkeley.edu/project/25504 By David Tuller, DrPH Poor Professor Michael Sharpe. […] (Source: virology blog)
Source: virology blog - April 15, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Kelland monbiot PACE Sharpe Source Type: blogs

Trial By Error: Jennie Spotila Tracks Down – and Busts – an Old Tale About “ Death Threats ” from Patients
By David Tuller, DrPH In early 2011, the first report of the PACE results in The Lancet drew widespread criticism from patients and advocates. Later that year, stories about unhinged, anti-science patients harassing and threatening leading researchers in the field appeared in high-profile UK outlets like BMJ and The Times. In the UK, this appears […] (Source: virology blog)
Source: virology blog - April 15, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized death threats spotila vicky whittemore Source Type: blogs

Trial By Error: A Letter to Psychological Medicine about Error in MUS Paper from Sir Simon and Colleagues
By David Tuller, DrPH I have previously documented that some of the leading experts in “medically unexplained symptoms” (MUS) have regularly misstated a core finding from a seminal study in their field. The study—”The cost of somatisation among the working-age population in England for the year 2008–2009”—was published in 2010 in the journal Mental Health […] (Source: virology blog)
Source: virology blog - April 13, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized MUS Psychological Medicine Wessely Source Type: blogs

Trial By Error: Journal of Health Psychology Publishes Hughes-Tuller Critique of Wessely-Chalder CBT Claims
By David Tuller, DrPH What kind of researchers would publish obviously misleading figures about their favorite intervention in a study abstract? And who would make causal claims in a paper while simultaneously pointing out that the study design does not allow for causal claims? Well, it seems Professor Sir Wessely and Professor Trudie Chalder, along […] (Source: virology blog)
Source: virology blog - April 10, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized CBT chalder Hughes Wessely Source Type: blogs

A tapeworm drug to treat COVID-19?
Niclosamide (pictured) is a drug that has been approved in humans to treat infections with a variety of tapeworms. It might be useful for preventing SARS-CoV-2 replication and COVID-19 pathogenesis by inhibiting virus-catalyzed membrane fusion. Examination of the lungs of 41 patients who died of COVID-19 revealed, in addition to expected lung injury, the presence […] (Source: virology blog)
Source: virology blog - April 9, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology coronavirus COVID-19 Niclosamide pandemic syncytium viral viruses Source Type: blogs

Trial By Error: Prof Sharpe Fact-Checks Comment on Blog About How George Monbiot Is Causing Long COVID
By David Tuller, DrPH *April is crowdfunding month at Berkeley. I conduct this project as a senior fellow in public health and journalism and the university’s Center for Global Public Health. If you would like to support the project, here’s the place: https://crowdfund.berkeley.edu/project/25504 In a surprising development, Professor Michael Sharpe has left a comment on a […] (Source: virology blog)
Source: virology blog - April 8, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized George Monbiot Long Covid Michael Sharpe Source Type: blogs

Trial By Error: Guardian Columnist George Monbiot Is Causing Long COVID, Says Professor Michael Sharpe
By David Tuller, DrPH *April is crowdfunding month at Berkeley. I conduct this project as a senior fellow in public health and journalism and the university’s Center for Global Public Health. If you would like to support the project, here’s the place: https://crowdfund.berkeley.edu/project/25504 In a remarkable display of—well, I’m not even sure what to call it–Professor […] (Source: virology blog)
Source: virology blog - April 7, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Long Covid Michael Sharpe PACE Swiss Re Source Type: blogs

Trial By Error: Northwestern Law Professor Steve Lubet ’ s View of that Wall Street Journal Editorial
By David Tuller, DrPH I’ve already posted my thoughts about the ill-informed opinion piece by a psychiatrist-in-training that The Wall Street Journal published two weeks ago. The author’s dismissal of the Long COVID phenomenon as a result of delusions and mental illness elicited a lot of sharp responses online. The Wall Street Journal itself published […] (Source: virology blog)
Source: virology blog - April 6, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized lubet Wall Street Journal Source Type: blogs

Trial By Error: GETSET Study Reports Null Results for Self-Help Graded Exercise – but Declares Success Anyway
By David Tuller, DrPH The Journal of Psychosomatic Research (JSR), an influential publication. recently published an article that made a crucial point—in clinical trials, subjective outcomes are at “a greater risk of bias due to any unblinding.” The article, which I wrote about here, was authored by the journal’s current editor and two previous editors, […] (Source: virology blog)
Source: virology blog - April 6, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized GETSET Journal of Psychosomatic Research Peter White Source Type: blogs