Trial By Error: New Study Reports First-Hand Accounts of 1955 Hospital Outbreak
By David Tuller, DrPH The name myalgic encephalomyelitis is inextricably linked with an outbreak of what appeared by all accounts to be a viral illness at London’s Royal Free Hospital in the second half of 1955. More than 200 people, most of them female staff and students, fell ill. Some reported long-term complications. Although no […] (Source: virology blog)
Source: virology blog - January 15, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Camelids for COVID
Human monoclonal antibodies that block infection with SARS-CoV-2 are being used to treat COVID-19 patients, but an alternative, antibodies produced in camelids (alpacas and llamas) might have advantages. Camelid monoclonal antibodies can be more cheaply produced in mass quantities in bacteria, and protein engineering can be quickly used to produce a better therapeutic product. Human […] (Source: virology blog)
Source: virology blog - January 15, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information camelid coronavirus COVID-19 monoclonal antibody pandemic SARS-CoV-2 viral viruses Source Type: blogs

Trial By Error: Tack ’ s Take on 2020 Studies; Professor Edwards ’ Statement to NICE
By David Tuller, DrPH I have been laying low during the recent holiday and coup season. Today I’m watching the impeachment hearings. And I might find it challenging to get back up to full speed until after New Year’s–which for me will be January 20th, or whichever day the White House is finally de-Trumped. For […] (Source: virology blog)
Source: virology blog - January 13, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

RNA, in a Nutshell
The mRNA vaccine platform is based on decades of previous studies, highlighting the importance of regularly funding basic research. (Source: virology blog)
Source: virology blog - January 7, 2021 Category: Virology Authors: Trudy Rey Tags: Basic virology Gertrud Rey cancer mRNA vaccines cholesterol encapsulated lipid nanoparticle PEG polyethylene glycol pre-fusion spike protein rsv SARS-CoV-2 Source Type: blogs

Musings of an anonymous, pissed off virologist
by Paul Bieniasz Dr. Bieniasz is Professor and Investigator of the Howard Hughes Medical Institute at Rockefeller University. As viruses go, SARS-CoV-2, is quite easy to neutralize with antibodies and, it turns out, straightforward to generate effective vaccines based on the spike protein. Perhaps, even probably, those two properties are causally related. Moreover, it appears […] (Source: virology blog)
Source: virology blog - January 5, 2021 Category: Virology Authors: Vincent Racaniello Tags: Commentary coronavirus COVID-19 pandemic SARS-CoV-2 viral virology viruses Source Type: blogs

Trial By Error: Psych Issues Do Not Predict ME/CFS, New Chicago Study Shows
By David Tuller, DrPH For decades, investigators have argued over the causes of the illness or cluster of illnesses variously called myalgic encephalomyelitis (ME), chronic fatigue syndrome (CFS),  ME/CFS, CFS/ME and other names. In the absence of an adequate explanation for the debilitating symptoms, a flawed approach to intervention based on the perceived need for […] (Source: virology blog)
Source: virology blog - December 30, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Swedish ME Patient Fears Forced Psychiatric Treatment
By David Tuller, DrPH Holger Klintenberg, a 35-year-old from the southern Swedish city of Jonkoping, has severe ME. His illness began after a bout of mononucleosis (or glandular fever) when he was 19. He has recently experienced difficult interactions with the health care system. His family fears he could be forced into psychiatric care against […] (Source: virology blog)
Source: virology blog - December 30, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Swedish ME Patient Fears Forced Psychiatric Treatment
By David Tuller, DrPH Holger Klintenberg is a severe ME patient in Jonkoping, a city in southern Sweden. He has recently experienced difficult interactions with the health care system. His family fears he could be forced into psychiatric care against his and their wishes. They are concerned that the medical professionals overseeing Holger’s care do […] (Source: virology blog)
Source: virology blog - December 29, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

SARS-CoV-2 UK variant: Does it matter?
A variant of SARS-CoV-2 has been spreading within England, and it has been suggested that this virus is more transmissible. In this video Vincent explains the properties of the SARS-CoV-2 UK variant and why claims that it is more transmissible are not supported by experimental data. This video was recorded on Monday, 21 December 2020. […] (Source: virology blog)
Source: virology blog - December 24, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Video coronavirus COVID-19 pandemic SARS-CoV-2 spike protein transmission UK variant variant of concern viral viruses VOC202012/01 Source Type: blogs

Trial By Error: A Letter to BMJ From Prof Hughes, Prof Racaniello and Me
By David Tuller, DrPH I have sent the following letter to Fiona Godlee, editorial director of BMJ and editor-in-chief of The BMJ, on behalf of Professors Brian Hughes and Vincent Racaniello as well as me. We were responding to the recent editorial regarding the new draft of ME/CFS clinical guidelines from the National Institute for […] (Source: virology blog)
Source: virology blog - December 22, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized BMJ editorial draft Fiona Godlee NICE Source Type: blogs

Trial By Error: BMJ Pushes Back Against New NICE Draft
By David Tuller, DrPH The BMJ has published an online “editorial” slamming the new draft of clinical guidelines for ME/CFS from the National Institute for Health and Care Excellence. The position expressed is an interesting one: Non-pharmacological treatments for “complex conditions” cannot be adequately measured by randomized trials, according to the two authors. It is, […] (Source: virology blog)
Source: virology blog - December 21, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized BMJ NICE Source Type: blogs

Encouraging clinical data for universal flu vaccine candidate
by Helen Stillwell The results from a phase I clinical trial to test the safety and immunogenicity of a universal flu vaccine candidate reported encouraging results – strong titers of broad and functional antibodies persisted for over a year in healthy adults following vaccination.  Influenza viruses contain segmented RNA genomes. The viral envelope contains two types glycoproteins […] (Source: virology blog)
Source: virology blog - December 17, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Helen Stilwell antibody HA stem influenza phase I clinical trial universal flu vaccine viral virus viruses Source Type: blogs

TWiV 693: Vax to the future
On this episode, FDA EUA for Pfizer mRNA vaccine, efficacy of AstraZeneca ChAdOx1 COVID-19 vaccine, and an orally administered drug that blocks SARS-CoV-2 transmission in ferrets. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Click arrow to playDownload TWiV 693 (69 MB .mp3, 115 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - December 17, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral drug ChAdOx1 coronavirus COVID-19 EIDD-2801 ferret MK-4482 mRNA vaccine nucleoside analog pandemic Pfizer SARS-CoV-2 virus transmission viruses Source Type: blogs

Trial By Error: Professors Chalder and Crawley Join Forces to Push CBT for Kids
By David Tuller, DrPH On November 10th, the National Institute of Health and Care Excellence published a draft of new clinical guidelines for ME/CFS. The draft represented a blunt rejection of the argument that the combination of “unhelpful cognitions” and deconditioning drives the illness. Under this once-hegemonic framework, indicated therapies include cognitive behavior therapy to […] (Source: virology blog)
Source: virology blog - December 16, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized CBT chalder Crawley Lightning Process NICE draft Source Type: blogs

An antiviral compound that blocks SARS-CoV-2 transmission in ferrets
COVID-19 vaccine candidates are garnering all the news these days, which is appropriate as they are our key to ending this pandemic. Earlier in this outbreak antiviral drugs received a good deal of attention, but they have proven less useful in curtailing infection. Less discussed are the many antiviral drug candidates that are in testing, […] (Source: virology blog)
Source: virology blog - December 11, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antiviral drug coronavirus COVID-19 EIDD-2801 ferret MK-4482 N4-hydroxycytidine NHC pandemic SARS-CoV-2 viruses Source Type: blogs

Trial By Error: Letter to Author of Removed GET/CBT Training Program for GPs
By David Tuller, DrPH Earlier today, I posted a blog about the decision by the Royal College of General Practice to remove from its site a training program called METRIC, which promoted the GET/CBT approach. I then sent the following letter to Carolyn Chew-Graham, a professor of general practice research at Keele University in Staffordshire […] (Source: virology blog)
Source: virology blog - December 11, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Chew-Graham METRIC Source Type: blogs

Trial By Error: GP Group Removes Online GET/CBT Medical Training Program
By David Tuller, DrPH In early 2019, I wrote about an awful online training course for general practitioners on recognizing and caring for patients diagnosed with what was referred to as CFS/ME. The module, called METRIC, promised to provide “GPs and other primary care practitioners with an overview of the presentation, diagnosis, assessment and ongoing […] (Source: virology blog)
Source: virology blog - December 10, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Chew-Graham METRIC Source Type: blogs

Trial By Error: My Zoom-Talk on the NICE Draft for Sheffield ME Group
By David Tuller, DrPH On Monday, I gave a Zoom-talk hosted by the Sheffield ME & Fibromyalgia Group on the new draft of ME/CFS clinical guidelines from UK’s National Institute of Health and Care Excellence. The draft rejected the GET/CBT treatment paradigm. I haven’t watched the video, but most likely one of my eyebrows is […] (Source: virology blog)
Source: virology blog - December 9, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized NICE draft Sheffield Source Type: blogs

My at-home SARS-CoV-2 antibody test result
Recently I had a false positive PCR result for SARS-CoV-2. To confirm that I was not infected, I did an assay for viral antibodies in my blood using a rapid, at home, lateral flow assay. In this video I explain how the assay works and what my results mean. (Source: virology blog)
Source: virology blog - December 9, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antibody test coronavirus COVID-19 IgG IgM lateral flow assay pandemic SARS-CoV-2 viral viruses Source Type: blogs

Trial by Error: FDA Approves Web-CBT for IBS; GET/CBT as Tomorrow ’ s “ Rubbish ”
By David Tuller, DrPH Mahana set to announce FDA approval for ineffective IBS program Earlier this year, I spent a lot of time blogging about the unethical and dishonest manner in which a San Francisco start-up called Mahana Therapeutics was promoting an eight-week web-based program of cognitive behavior therapy for patients suffering from irritable bowel […] (Source: virology blog)
Source: virology blog - December 7, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized british journal of general practice CBT IBS mahana Matthew Holt ross-morris Trudie Chalder Source Type: blogs

TWiV 690: This is your brain on SARS-CoV-2
TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients. Click arrow to playDownload TWiV 690 (71 MB .mp3, 120 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - December 6, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology ACE2 central nervous system coronavirus COVID-19 mink neurotropic olfactory mucosa pandemic SARS-CoV-2 species specificity spike glycoprotein viral viruses Source Type: blogs

TWiV 689: COVID-19 clinical update #39 with Dr. Daniel Griffin
Daniel Griffin provides his weekly clinical report on COVID-19, including analysis of vitamin D levels in patients, information on Moderna and Pfizer vaccines, distribution plans suggested by ACIP, and more. Click arrow to playDownload TWiV 689 (22 MB .mp3, 37 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - December 5, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology coronavirus COVID-19 pandemic SARS-CoV-2 vaccine viral viruses vitamin D Source Type: blogs

Pandoraviruses Are Not Alive
Pandoraviruses seemingly have the ability to produce an electrical potential across their membrane, a feature that is typically only associated with living cells. (Source: virology blog)
Source: virology blog - December 3, 2020 Category: Virology Authors: Trudy Rey Tags: Basic virology Gertrud Rey acetyl-CoA amoeba ATP citrate synthase citric acid cycle concentration gradient electrical potential electron transport chain electrons energy giant virus isocitrate dehydrogenase Krebs cycle living Source Type: blogs

Trial By Error: Thoughts on The Observer, The Guardian, and Paradigm Shift
By David Tuller, DrPH Earlier this week, I blogged about a story in The Observer that provided an inaccurate description of what it called chronic fatigue syndrome. For much of the piece, the writer, Eleanor Morgan, offered a sympathetic portrait of people, including herself, experiencing prolonged symptoms after an acute bout of Covid-19. A lot […] (Source: virology blog)
Source: virology blog - December 2, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Guardian observer shepherd Weir Source Type: blogs

Trial By Error: The Observer Slips Up; ME Association Responds
By David Tuller, DrPH News organizations continue to misrepresent ME (and its various iterations) in their coverage of what has come to be called long-Covid. A current UK example is Sunday’s Observer article by writer Eleanor Morgan, who is experiencing prolonged symptoms since falling ill last spring. (It’s on The Guardian site; the two organizations […] (Source: virology blog)
Source: virology blog - November 30, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Charles Shepherd long-covid ME Association observer Source Type: blogs

TWiV 685: Pandemicky
The TWiVers analyze efficacy of the AstraZeneca/Oxford adenovirus vectored vaccine, SARS-CoV-2 did not infect miners who became ill 8 years ago after cleaning bat guano from a cave in Yunnan Province, and induction of antigen-specific germinal center responses and production of neutralizing antibody by SARS-CoV-2 mRNA vaccine but not purified protein. Click arrow to playDownload TWiV […] (Source: virology blog)
Source: virology blog - November 27, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology bat guano coronavirus COVID-19 follicular T helper cell germinal center memory B cell mRNA vaccine neutralizing antibody pandemic protein vaccine RaTG13 SARS-CoV-2 spike protein viral viruses Source Type: blogs

TWiV 684: Persistence of SARS-CoV-2 immune memory
Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived. Click arrow to playDownload TWiV 684 (110 MB .mp3, 184 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 27, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antibody b cells coronavirus COVID-19 immune memory pandemic SARS-CoV-2 T cells viral viruses Source Type: blogs

Trial By Error: My Letter to BMJ Paediatrics Open about the CBT-Music Therapy Study
This study was published in April by BMJ […] (Source: virology blog)
Source: virology blog - November 25, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized BMJ music therapy norway Pediatrics Source Type: blogs

Trial By Error: Update on BMJ ’ s CBT-Music Therapy Study (h/t Steinkopf and Tack)
By David Tuller, DrPH I have written multiple posts this year about a Norwegian study of cognitive behavior therapy plus music therapy as a treatment for chronic fatigue after acute EBV infection (aka mononucleosis and glandular fever). The study, published in April by BMJ Paediatrics Open, was rife with methodological and ethical flaws. It should not have […] (Source: virology blog)
Source: virology blog - November 24, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized BMJ CBT music therapy Nina Steinkopf norway Tack Source Type: blogs

Trial By Error: The Science Media Centre and UK ’ s Coverage of New NICE Draft
By David Tuller, DrPH As Trump’s legal team continues to spout nonsense rather than acknowledge that the orange balloon lost the election, core members of the UK’s biopsychosocial ideological brigades are also engaged in embarrassing denialism. Last week, a draft of new ME/CFS clinical guidelines issued by a key British health agency advised against graded […] (Source: virology blog)
Source: virology blog - November 21, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Cigarette smoke increases infection severity of SAR-CoV-2 in airway cells in culture
Cigarette smoking appears to be associated with more severe COVID-19, but the underlying mechanisms have not been deciphered. The results of infection of airway cells in culture with SARS-CoV-2 provide some insight. Smoking is the most important cause of chronic lung disease, which in turn is a risk factor for severe COVID-19. Some studies have […] (Source: virology blog)
Source: virology blog - November 20, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information cigarette smoke coronavirus COVID-19 interferon pandemic respiratory epithelium SARS-CoV-2 viral viruses Source Type: blogs

TWiV 683: Two COVID-19 mRNA vaccines
On this episode of TWiV, mRNA vaccines from Moderna and Pfizer show over 90% efficacy, prothrombotic auto-antibodies in serum of COVID-19 patients, and the whereabouts of SARS-CoV-2 in the human body. Click arrow to playDownload TWiV 683 (72 MB .mp3, 119 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 19, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology autoantibodies blood clots coronavirus COVID-19 mRNA vaccine pandemic phospholipid SARS-CoV-2 thrombosis tissue tropism viral viruses Source Type: blogs

TWiV 682: Kate Rubins from the International Space Station
From Expedition 64 of International Space Station, Flight Engineer Kate Rubins joins TWiV to discuss experiments that she is working on, including cell cultures, genome sequencing, and plant growth. Click arrow to playDownload TWiV 682 (17 MB .mp3, 29 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 19, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology astronaut International Space Station ISS Expedition 64 Kate Rubins NASA science in space viral virus viruses Source Type: blogs

TWiV 681: Crowley, coats, and cross-reactive antibodies
Daniel Griffin provides a clinical report on COVID-19, Kathleen Crowley explains the role of Environmental Health & Safety departments, update on SARS-CoV-2 transmission in farmed mink, and the presence of pre-existing antibodies to SARS-CoV-2 in unexposed individuals. Click arrow to playDownload TWiV 681 (107 MB .mp3, 179 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 19, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology coronavirus COVID in mink COVID-19 cross-reactive antibodies environmental health and safety pandemic Pfizer SARS-CoV-2 vaccine viral viruses Source Type: blogs

Trial By Error: Jennie Spotila ’ s Annual Review of NIH Funding
By David Tuller, DrPH Every year, Jennie Spotila posts her analysis of annual funding for ME from the US National Institutes of Health on her invaluable blog, Occupy M.E. (On the other hand, Occupy Me is a 16-minute gay drama from 2015 about an interlude between two guys. I have no idea if it’s any […] (Source: virology blog)
Source: virology blog - November 15, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

First efficacy results of a COVID-19 vaccine candidate
Results on efficacy of the first of the SARS-CoV-2 candidate vaccines has been announced by Pfizer this week. The company states that the viral spike-encoding mRNA vaccine candidate was found to be more than 90% effective in preventing COVID-19. This announcement is good news, but in itself does not signal the end of the pandemic. […] (Source: virology blog)
Source: virology blog - November 13, 2020 Category: Virology Authors: Vincent Racaniello Tags: Uncategorized Source Type: blogs

TWiV 680: Long-term COVID and ME/CFS
Mady Hornig, Fiona Lowenstein, and David Tulles join TWiV to discuss patients with long-term COVID and similarities and differences with ME/CFS. Click arrow to playDownload TWiV 680 (67 MB .mp3, 112 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 13, 2020 Category: Virology Authors: Vincent Racaniello Tags: Uncategorized chronic disease coronavirus COVID-19 long haulers long-term COVID ME/CFS pandemic SARS-CoV-2 viral virology viruses Source Type: blogs

TWiV 679: Mink, mutation, and myocytes
Daniel Griffin provides a clinical report on COVID-19, Slovlakia’s plan to test all adults for SARS-CoV-2 infection, viral variants arising in Danish mink and their potential threat to humans, why it is unethical to carry out challenge trials, Nipah virus dynamics in bats and spillovers into humans, and direct cardiac damage by spike-mediated cardiomyocyte fusion. […] (Source: virology blog)
Source: virology blog - November 11, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology Source Type: blogs

Trial By Error: NICE Draft Rejects GET, Lightning Process, and CBT-As-Cure
By David Tuller, DrPH The draft of the new ME/CFS guidance from the UK’s National Institute for Health and Care Excellence is out–posted just after midnight, London time, on Tuesday, November 10. This is the headline: The draft represents a repudiation of the GET/CBT paradigm and the deconditioning hypothesis. Here are key take-aways: *Graded exercise […] (Source: virology blog)
Source: virology blog - November 10, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: With Trump Out, Can GET/CBT Be Next?
By David Tuller, DrPH I have often described the logic demonstrated by the biopsychosocial ideological brigades as Trumpian in nature. Like the fat loser about to be expelled from his big home in Washington, D.C., this cabal of British experts have long relied on “alternative facts”—in their case to promote graded exercise therapy and cognitive […] (Source: virology blog)
Source: virology blog - November 9, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: My Predictions for NICE ME/CFS Guidance, Reprise
By David Tuller, DrPH UC Berkeley’s crowdfunding campaign ended successfully last Saturday–thanks, all!!–but I haven’t managed to get much done in the news-filled week since then. I was prepared to have to join the resistance in the hills around the Berkeley campus, but now that has become unnecessary. Whew! Now that I no longer have […] (Source: virology blog)
Source: virology blog - November 7, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

T Cell Responses to Coronavirus Infection are Complicated
Some have suggested that pre-existing cross-reactive memory T cells in people with no prior exposure to SARS-CoV-2 may have a protective effect. However, recent findings indicate that this may not be the case. (Source: virology blog)
Source: virology blog - November 5, 2020 Category: Virology Authors: Trudy Rey Tags: Basic virology Gertrud Rey cross-reactive T cells immunological age memory T cells naive T cells prior exposure SARS-CoV-2 seasonal human coronaviruses severe COVID-19 T helper cells Source Type: blogs

My Zoom Bookshelf
In this short video, I take you through some of the science books on my bookshelf, next to the desk where lately I have been spending a lot of time on Zoom. Not surprisingly, most of the books are about viruses. (Source: virology blog)
Source: virology blog - November 4, 2020 Category: Virology Authors: Vincent Racaniello Tags: Uncategorized bookshelf COVID-19 pandemic SARS-CoV-2 science books viral virology virus viruses Zoom Source Type: blogs

Trial By Error: No Links Between “ Parental Separation ” and Kids ’ ME Severity
By David Tuller, DrPH When last heard from, Terry Segal, a pediatrician at University College London, was the senior author of a 2019 review of pediatric treatments for what the authors called “CFS/ME.” The review was published in Current Opinion in Pediatrics, a high-impact journal. The abstract for the review singled out the Lightning Process […] (Source: virology blog)
Source: virology blog - November 3, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 677: Does antibody really know what time it is?
Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more. Click arrow to playDownload TWiV 677 (97 MB .mp3, 162 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become […] (Source: virology blog)
Source: virology blog - November 3, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology coronavirus COVID-19 face mask immune memory neutralizing antibody pandemic SARS-CoV-2 vaccine viral viruses Source Type: blogs

Antiviral antibodies in COVID-19 patients
In infectious disease world, the term “correlate of protection” refers to something that can be measured – antibodies or T cells – which indicates that a person is protected against infection or disease. The correlates of protection for SARS-CoV-2 infection of humans are not yet known – after all it is still early in this […] (Source: virology blog)
Source: virology blog - October 30, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology antibody B cell memory coronavirus correlate of protection COVID-19 pandemic SARS-CoV-2 spike glycoprotein viral Source Type: blogs

TWiV 676: Tragic gene flow from Neanderthals
In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient. (Source: virology blog)
Source: virology blog - October 29, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology coronavirus COVID-19 genome wide association study GWAS immunocompromised immunosuppressed pandemic SARS-CoV-2 single nucleotide polymorphism SNIP viral Source Type: blogs

Trial By Error: BMJ Retracts Music Therapy-CBT Study, But …
By David Tuller, DrPH *October is crowdfunding month at Berkeley. I conduct this project as a senior fellow in public health and journalism and the university’s Center for Global Public Health. If you would like to support the project, here’s the place: https://crowdfund.berkeley.edu/project/22602 I have written many posts this year about a Norwegian study of cognitive […] (Source: virology blog)
Source: virology blog - October 27, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized BMJ CBT music therapy study norway Source Type: blogs

Trial By Error: The British Association for CFS/ME Switches Gears
By David Tuller, DrPH *October is crowdfunding month at Berkeley. I conduct this project as a senior fellow in public health and journalism and the university’s Center for Global Public Health. If you would like to support the project, here’s the place: https://crowdfund.berkeley.edu/project/22602 On October 20th, the British Association for CFS/ME issued a document titled “Position […] (Source: virology blog)
Source: virology blog - October 27, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized BACME NICE Source Type: blogs

TWiV 675: Forget what you ’ ve herd about immunity
Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege’s letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus. Click arrow to playDownload TWiV 675 (105 MB .mp3, 174 min)Subscribe (free): iTunes, Google […] (Source: virology blog)
Source: virology blog - October 27, 2020 Category: Virology Authors: Vincent Racaniello Tags: Commentary This Week in Virology ACE2 coronavirus COVID-19 entry protein neuropilin pandemic SARS-CoV-2 vaccine viral viruses Source Type: blogs