Trial By Error: An Australian Radio Interview with Melbourne ’ s Dr Mark Guthridge
By David Tuller, DrPH When I was in Australia two years ago–wow, can’t believe it’s been that long!–I spent some time with Dr Mark Guthridge, an associate professor of biomedical science at Deakin University in Melbourne. Several years ago, after a bout of mononucleosis/glandular fever, he developed myalgic encephalomyelitis, which in Australia even patients and […] (Source: virology blog)
Source: virology blog - February 19, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: My Follow-up Letter to Mahana Therapeutics ’ CEO
By David Tuller, DrPH Last week, I wrote to Rob Paull, the co-founder and CEO of Mahana Therapeutics, regarding the company’s misleading claims about the web-based cognitive behavior therapy program for irritable bowel syndrome it recently licensed from King’s College London. I have also written to Professor Rona Moss-Morris, the co-lead investigator of ACTIB, the […] (Source: virology blog)
Source: virology blog - February 17, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Furin cleavage site in the SARS-CoV-2 coronavirus glycoprotein
The spike glycoprotein of the newly emerged SARS-CoV-2 contains a potential cleavage site for furin proteases. This observation has implications for the zoonotic origin of the virus and its epidemic spread in China. The membrane of coronaviruses harbors a trimeric transmembrane spike (S) glycoprotein (pictured) which is essential for entry of virus particles into the […] (Source: virology blog)
Source: virology blog - February 14, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information bat coronavirus COVID-19 epidemic furin SARS-CoV-2019 spike glycoprotein viral viruses Wuhan zoonosis Source Type: blogs

Trial By Error: Some Thoughts on IBS, CFS, MUS, PACE, ACTIB and IAPT (Whew!)
By David Tuller, DrPH It might not be clear to many readers just why I’m spending time writing about irritable bowel syndrome when this series is supposed to be about the illness called myalgic encephalomyelitis (also referred to as chronic fatigue syndrome, ME/CFS, CFS/ME and other terms). The reason is that the two conditions have […] (Source: virology blog)
Source: virology blog - February 13, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: My Letter to Mahana ’ s CEO and Co-Founder
By David Tuller, DrPH Venture capitalist Robert Paull is listed on the Mahana Therapeutics website as the company’s co-founder and CEO. I have no idea how he got involved with this group of UK researchers and King’s College London. Given my own experiences, I would certainly have advised him against getting in bed with them, […] (Source: virology blog)
Source: virology blog - February 12, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: My Letter to Two More Mahana GI Advisors
By David Tuller, DrPH I’ll soon post a blog on why I’m spending so much time on this IBS issue when I’m supposed to be focused on ME (or CFS, ME/CFS, CFS/ME, or whatever term is being used to refer to this illness or cluster of related illnesses). In the meantime, here’s a copy of […] (Source: virology blog)
Source: virology blog - February 11, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: My Follow-Up Letter to Professor Rona Moss-Morris
By David Tuller, DrPH Ten days ago, I sent a letter to Professor Rona Moss-Morris of King’s College London, seeking information about the licensing deal involving her web-based program of cognitive behavior therapy to treat irritable bowel syndrome. Since I have not heard back, this morning I made a second attempt to reach out to […] (Source: virology blog)
Source: virology blog - February 10, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 586: Coronavirus update: wash your hands
In this week’s coverage of the coronavirus epidemic, the TWiV team discusses the fatality rate, China’s initial reaction to the outbreak, conspiracy theories, how long the virus remains infectious on surfaces, and evidence for virus in the intestinal tract. Click arrow to play Download TWiV 586 (72 MB .mp3, 119 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! […] (Source: virology blog)
Source: virology blog - February 9, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology 2019-nCoV coronavirus epidemic ethanol hand gel handwashing outbreak response transmission vaccine viral virulence viruses Wuhan Source Type: blogs

CRISPR-ing herpes simplex virus
by Gertrud U. Rey Herpes simplex viruses establish lifelong persistent infection in sensory neurons of infected individuals, a phenomenon called latency. Latent viral genomes are “dormant” but can sporadically reactivate and begin replicating in a phase called lytic replication, which is often accompanied by shedding of virus particles and the appearance of painful lesions. There […] (Source: virology blog)
Source: virology blog - February 7, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Gertrud Rey Information cold sore crispr genome editing herpes simplex virus herpesvirus latency reactivation viral viruses Source Type: blogs

Trial By Error: My Letter to One of Mahana ’ s Gastroenterology Advisors
By David Tuller, DrPH On its website, Mahana Therapeutics has listed sixteen gastroenterology and psychology advisors from prominent academic and medical institutions. Companies often add such names to their rosters as a way of signaling their significance and their access to great minds. Sometimes these people are compensated; sometimes not. In many instances, these advisors play little […] (Source: virology blog)
Source: virology blog - February 5, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: My Letter to Professor Moss-Morris
By David Tuller, DrPH Last week I wrote about the recently announced licensing deal between Mahana Therapeutics and King’s College London. The deal involves a web-based course of cognitive behavior therapy designed to treat irritable bowel syndrome. In a major study, the reported improvements in symptoms among participants in the web-based program were modest at […] (Source: virology blog)
Source: virology blog - February 3, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 585: The coronavirus epidemic
The TWiVerers continue their coverage of the new coronavirus outbreak in China, as the number of cases increase dramatically and the virus begins person-to-person transmission in other countries. Click arrow to play Download TWiV 585 (71 MB .mp3, 118 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - February 3, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology 2019-nCoV bat viral genome coronavirus epidemic pandemic pneumonia R0 reproductive index spillover transmission viruses Wuhan zoonosis Source Type: blogs

The growing coronavirus epidemic
An unprecedented amount of information is emerging on the new coronavirus, provisionally called 2019-nCoV, that originated in China and is spreading globally. As of this writing there are 8,236 confirmed cases (8,124 in China) with 171 deaths (Click the link for real-time updates). What was the origin of the virus? The virus was first isolated […] (Source: virology blog)
Source: virology blog - January 31, 2020 Category: Virology Authors: Vincent Racaniello Tags: Uncategorized 2019-nCoV bat China coronavirus epidemic reproductive index viral virology viruses Wuhan zoonosis Source Type: blogs

Trial By Error: More on the Mahana Therapeutics Deal
By David Tuller, DrPH As I wrote yesterday, Mahana Therapeutics has recently licensed from King’s College London an “innovative digital therapeutic”—a web-based program delivering a course of cognitive behavioral therapy to patients with irritable bowel syndrome. A page on the Mahana site promoting this web-delivered IBS-CBT program furthers the impression that this deal is steeped […] (Source: virology blog)
Source: virology blog - January 28, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: My FOI Request to King ’ s College London; My Letter to Mahana Therapeutics
By David Tuller, DrPH Yesterday I sent a freedom-of-information request to King’s College London about the recently announced licensing deal it has with Mahana Therapeutics. The deal involves a web-based CBT program for irritable bowel syndrome, which I have written about here and here. This morning I sent a note to the e-mail address for […] (Source: virology blog)
Source: virology blog - January 27, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: A Commercial Deal for King ’ s College London ’ s IBS-CBT Digital Program
By David Tuller, DrPH On January 10th, the following information was announced in a press release: Mahana Therapeutics, a digital therapeutics company reimagining the treatment of chronic diseases, today announced that the Company has entered into a licensing and collaboration agreement with King’s College London, a leading research university and one of the oldest and […] (Source: virology blog)
Source: virology blog - January 27, 2020 Category: Virology Authors: David Tuller Tags: David Tuller ME/CFS Source Type: blogs

TWiV 584: Year of the coronavirus
Coronavirus expert Ralph Baric joins TWiV to explain the virology and epidemiology of the recent zoonotic outbreak spreading across China and overseas. Click arrow to play Download TWiV 584 (64 MB .mp3, 106 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - January 26, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology bat China coronavirus epidemiology spillover travel restriction viral viruses Wuhan zoonosis Source Type: blogs

Trial By Error: CBT and Irritable Bowel Syndrome
By David Tuller, DrPH Had things gone as planned, the PACE trial should have been able to serve as proof that so-called medically unexplained symptoms (MUS)—in this case what the investigators referred to as chronic fatigue syndrome–could be successfully treated with psychological and behavioral therapies. The Lancet published the first PACE results, which reported benefits […] (Source: virology blog)
Source: virology blog - January 24, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

A lesson from SARS-CoV for 2019-nCoV
As with all previous outbreaks of new virus infections, we are being warned of impending doom concerning the new coronavirus, 2019-nCoV that is now spreading globally. China’s National Health Commission Vice Minister Li Bin recently warned that ‘there is the possibility of viral mutation’. Perhaps Mr. Li is unaware that viral genomes sustain mutations during […] (Source: virology blog)
Source: virology blog - January 24, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information 2019-nCoV adaptation coronavirus mutation SARS selection viral Wuhan Source Type: blogs

Trial By Error: My Talk Last October at Oxford (Video)
By David Tuller, DrPH Last October, I gave a talk in Oxford (not AT Oxford) about the dung-heap known as the Lightning Process trial which was published in 2017 in Archives of Disease in Childhood, a BMJ journal. The study’s full name: “Clinical and cost-effectiveness of the Lightning Process in addition to specialist medical care for […] (Source: virology blog)
Source: virology blog - January 22, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 583: Galveston virus hunters
Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters. Click arrow to play Download TWiV 583 (51 MB .mp3, 84 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - January 19, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology arbovirus BSL4 laboratory ebolavirus galveston national laboratory hantavirus Nipah virus select agent Texas Medical Branch viral virus hunters viruses Source Type: blogs

Ancient viruses in glacier ice
The year 2019 was the second-hottest year on record, closing out the warmest decade. As the temperature rises, ice melts, and out come novel viruses. And there are many viruses frozen in ice, ready to spill out. We know that viruses are frozen in ice: multiple giant viruses have been isolated from the 30,000 year […] (Source: virology blog)
Source: virology blog - January 17, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information bacteriophage climate change glacier global warming Guliya ice cap ice microbes ice sheet ice viruses mountain glacier viral Source Type: blogs

Trial By Error: CBT Provides No Benefits to Advanced Cancer Patients, Study Finds
By David Tuller, DrPH Since 2008, the National Health Service (NHS) in England has been rolling out a program known as Improving Access to Psychological Therapies (IAPT). Initially focused on patients with mental health issues like depression and anxiety disorders, IAPT was then expanded to include those who are also simultaneously suffering from “long-term conditions” […] (Source: virology blog)
Source: virology blog - January 16, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: The UK ’ s Proposed Genetics Study
By David Tuller, DrPH In the UK, leading researchers are preparing to submit an application for a large genetic study to two major funding agencies. The project is being led by Professor Chris Ponting of the University of Edinburgh, who is also vice chair of the CFS/ME Research Collaborative, and the UK ME/CFS Biobank at […] (Source: virology blog)
Source: virology blog - January 13, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: The 2018 PACE Reanalysis and the SMC ’ s Expert Appraisals
By David Tuller, DrPH It has been almost two years since BMC Psychology published a key reanalysis of raw data from the PACE trial. Given the significance of this paper (of which I was the least important of seven co-authors), I figured it wouldn’t hurt to highlight it again. The heroic Alem Matthees, a patient […] (Source: virology blog)
Source: virology blog - January 13, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 582: This little virus went to market
TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle. Click arrow to play Download TWiV 582 (71 MB .mp3, 118 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - January 12, 2020 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology african swine fever virus capsid China coronavirus cryo-electron micrography giant virus Huanan Fish Market influenza influenza excess mortality influenza like illness influenza vaccine pig three dimensional Source Type: blogs

A new coronavirus causing respiratory disease in China
A new coronavirus appears to be causing a pneumonia-like illness in China. It is certainly a zoonotic infection – jumping from non-human animals to humans – as exemplified by previous outbreaks of SARS and MERS coronaviruses. The government in Wuhan, China confirmed on 31 December that dozens of cases of pneumonia of unknown cause were […] (Source: virology blog)
Source: virology blog - January 10, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information coronavirus emerging virus MERS pneumonia respiratory disease SARS viral viruses Wuhan outbreak zoonosis Source Type: blogs

Trial By Error: NIH Funding “ Needs Life Support, ” Says Jennie Spotila
By David Tuller, DrPH Every year, Jennie Spotila deconstructs NIH funding on her Occupy M.E. blog. Last November 7, she crunched the numbers for the 2019 fiscal year, and the same day posted another blog with a more urgent message. I am re-posting that blog in full (a bit late), with Jennie’s permission. ********** NIH Funding […] (Source: virology blog)
Source: virology blog - January 9, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: The Danish ME Association ’ s Open Letter
By David Tuller, DrPH The Danish ME Association has sent and posted the following open letter to “Danish health politicians,” with a very impressive list of international signatories. It seemed important to give this letter wide circulation. (Note that footnotes 4 and 5 are linked to the names of two of the signatories, as in […] (Source: virology blog)
Source: virology blog - January 8, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Some More Thoughts on Functional Neurological Disorder
By David Tuller, DrPH Last week I wrote a post on some of the signs used to diagnose people with “functional neurological disorder” (FND)—the phrase that has largely supplanted “conversion disorder” to describe neurological symptoms with no identified organic cause. In that post, I should have been clearer that I do not question whether people […] (Source: virology blog)
Source: virology blog - January 7, 2020 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Phi Kappa Zeta Builds a Panic Room
by Gertrud U. Rey Bacteria use at least a couple of pathways for protecting themselves against viral infection. In return, multiple viral strategies for inhibiting or evading these pathways have evolved. Two well-known bacterial strategies for self-defense against viruses involve immune enzymes, and roughly resemble the vertebrate innate and adaptive immune responses. Restriction enzymes, which […] (Source: virology blog)
Source: virology blog - January 2, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Gertrud Rey Information bacteriophage crispr giant virus infection defense nucleus-like shell phage φKZ viral viruses Source Type: blogs

Trial By Error: My 2011 Exchange with White et al about Case Definition
By David Tuller, DrPH My first exchange of views with the PACE authors involved the issue of case definition–the criteria used to identify the illness they  called chronic fatigue syndrome. This exchange took place courtesy of The New York Times, not long after The Lancet published the results of the PACE trial. In March, 2011, […] (Source: virology blog)
Source: virology blog - December 31, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Shaky Evidence for Signs of Functional Neurological Disorders
By David Tuller, DrPH One of my goals next year is to write more about so-called “medically unexplained symptoms,” also known as MUS. The term MUS might be useful as a descriptive name for the large category of phenomena that lack a proven pathophysiological pathway. But in the medical literature, and in the minds of […] (Source: virology blog)
Source: virology blog - December 30, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: PEM Is Bad and So Is Fukuda, New Study Finds
By David Tuller, DrPH A new study in the Journal of Psychosomatic Research, posted December 16th, has reported that patients with chronic fatigue syndrome who experience major post-exertional malaise have a greater burden of psychological distress than those whose PEM is minimal or non-existent. Of course, this is not surprising. The sicker people are, with […] (Source: virology blog)
Source: virology blog - December 24, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 579: Reno viral
Vincent speaks with virologists at the University of Nevada at Reno about their careers and their work on herpesviruses, arboviruses, and the development of diagnostics for infectious diseases. Click arrow to play Download TWiV 579 (61 MB .mp3, 101 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - December 22, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology arbovirus diagnostic assay herpesvirus Kaposi's sarcoma virus mosquito PAN RNA small RNA viral viruses Source Type: blogs

Antibiotics blunt the antibody response to influenza vaccine
The human gut microbiome appears to play diverse roles in host physiology, metabolism, and immunity. Most conclusions about what the trillions of bacteria in our intestines actually do come from studies in mice, or correlative studies in humans. An exception is an investigation in humans which shows that antibiotic-mediated alteration of the fecal microbiome* interferes […] (Source: virology blog)
Source: virology blog - December 19, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antibiotics antibody response influenza vaccine influenza virus microbiome trivalent inactivated influenza vaccine viral viruses Source Type: blogs

Trial By Error: My STAT Opinion Piece on BMJ and Dr Godlee
By David Tuller, DrPH On Friday, STAT posted my opinion piece about BMJ and the Lightning Process paper–in particular, about BMJ’s decision not to retract the paper despite the multiple documented violations of core ethical and methodological principles of medical research. That anti-scientific decision is potentially harmful not only to children suffering from a stigmatizing […] (Source: virology blog)
Source: virology blog - December 16, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Simon McGrath on Ron Davis on “ something in the blood ”
By David Tuller, DrPH Simon McGrath provides excellent accounts of research topics at his blog, ME/CFS Research Review. He is skilled at rendering complicated stuff into easy-to-understand prose. On December 10th, Simon posted this update of developments discussed by Stanford geneticist Ron Davis during a recent talk at the Albert Einstein College of Medicine in New […] (Source: virology blog)
Source: virology blog - December 16, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 578: Prometheus project
Vincent speaks with members of Prometheus, a team of academic and industrial scientists assembled to develop antibody-based therapeutics against infections caused by tick-borne Crimean-Congo hemorrhagic fever virus and rodent-borne hantaviruses, for which no approved vaccines or specific drugs are available. Click arrow to play Download TWiV 578 (55 MB .mp3, 91 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become […] (Source: virology blog)
Source: virology blog - December 15, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology Crimean-Congo hemorrhagic fever virus hantavirus monoclonal antibody therapy rodent-borne virus tick-borne virus U19 grant viral viruses Source Type: blogs

Nipah virus at 20
This week I attended the Nipah Virus International Conference in Singapore, marking the discovery of the virus 20 years ago. It’s an opportune time to recall the events around the emergence of this deadly pathogen. An outbreak of respiratory disease and encephalitis in pigs during 1998 took place in Ipoh City of Perak state in […] (Source: virology blog)
Source: virology blog - December 12, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information encephalitis fruit bat Hendra virus henipavirus Nipah virus pandemic Pteropus respiratory disease spillover viral viruses Source Type: blogs

Trial By Error: Mayo Clinic ’ s Crappy Website
By David Tuller, DrPH What’s going on at the Mayo Clinic? It has been more than two years since the US Centers for Disease Control and Prevention (CDC) removed cognitive behavior therapy and graded exercise therapy as treatments of choice for the illness it now calls ME/CFS. And Mayo still seems not to have noticed […] (Source: virology blog)
Source: virology blog - December 10, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 577: Virologie structurale with F élix Rey
Vincent speaks with Félix Rey about his career and his work on solving structures of a variety of viruses and the insights learned about viral membrane fusion and antibody-mediated neutralization. Click arrow to play Download TWiV 577 (46 MB .mp3, 75 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - December 8, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antibody neutralization cryo-EM dengue virus flavivirus fusion loop glycoprotein Semliki Forest virus tick borne encephalitis virus viral viral membrane fusion viruses X-ray crystallography zika virus Source Type: blogs

Trial By Error: Fiona Godlee Doubles Down on Lightning Process Study
By David Tuller, DrPH Earlier this week, Dr Fiona Godlee, editorial director of BMJ, e-mailed me in response to concerns expressed about the study of the Lightning Process published in Archives of Disease in Childhood, one of the journals under her purview. Those concerns were expressed in an open letter to her signed by 72 […] (Source: virology blog)
Source: virology blog - December 6, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

A Vaccine for Every Cold
by Gertrud U. Rey It is cold outside. My throat is scratchy, I can’t stop sneezing, and I have a runny nose. These are the typical symptoms of a human rhinovirus (HRV) infection, better known as the common cold. The average adult suffers from two to four colds a year, while the average child can […] (Source: virology blog)
Source: virology blog - December 5, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Gertrud Rey Information adjuvant antibody common cold multivalent vaccine rhinovirus viral viruses Source Type: blogs

Trial By Error: More Calls to Godlee for LP Study Retraction
By David Tuller, DrPH Last last month, I resent Dr Fiona Godlee a letter criticizing BMJ’s decision to republish the Lightning Process study with the same findings. The first iteration, in July, was signed by 55 scientists, clinicians and other experts. This version was signed by more than 70 experts and over 60 patient and […] (Source: virology blog)
Source: virology blog - December 2, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Professor Jonathan Edwards ’ View of ME
By David Tuller, DrPH Professor Jonathan Edwards posted this essay a while ago on the Science For ME forum. I only noticed it recently. Professor Edwards, a retired rheumatologist from University College London, has played a key role n the last few years as an advocate for patients as well as proper science. So I […] (Source: virology blog)
Source: virology blog - December 2, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 576: Big data in virology and public health
From the 22nd meeting of the European Society for Clinical Virology in Copenhagen, Vincent speaks with Thea, Heli, Kim, Caroline and Irma about big data and its increasing use in virology diagnostics, epidemiology, and public health. Click arrow to play Download TWiV 576 (33 MB .mp3, 54 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at […] (Source: virology blog)
Source: virology blog - December 2, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology clinical virology diagnostic virology epidemiology next generation sequencing public health virus viruses WHO Source Type: blogs

TWiEVO 49: A giant podcast on giant viruses
Rich joins Nels and Vincent for a debriefing on the 4th Ringberg Symposium on Giant Virus Biology in Tegernsee, Germany. Click arrow to play Download TWiEVO 49 (68 MB .mp3, 113 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Show notes at microbe.tv/twievo (Source: virology blog)
Source: virology blog - November 29, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Evolution ecology giant virus horizontal gene transfer natural selection NCLDV Nucleocytoplasmic large DNA containing viruses phycodnavirus Ringberg trisymmetron viral virology virophage Source Type: blogs

TWiV 575: Endless giant virus forms most beautiful
From the Fourth Symposium on Giant Virus Biology in Germany, Vincent, Rich, and Nels speak with Assaf, Stephen, and Alexandra about their careers and their work on giant viruses that infect ocean hosts: Emiliana huxleyi, Aureococcus anophagefferans, and a choanoflagellate.  https://youtu.be/4njTGaKuM-0 Click arrow to play Download TWiV 575 (73 MB .mp3, 121 min) Subscribe (free): iTunes, Google […] (Source: virology blog)
Source: virology blog - November 24, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology algal virus Aureococcus anophagefferans brown tide choanoflagellate Emiliana huxleyi giant virus in plaque-MSI lipidomics marine carbon cycle mass spectrometry metabolic landscape mimiviridae mimivirus NCL Source Type: blogs

Trial By Error: Open Letter to Dr Godlee about BMJ ’ s Ethically Bankrupt Actions (2)
By David Tuller, DrPH In July, I sent Dr Fiona Godlee, editorial director of BMJ, a letter signed by 55 experts about her company’s perplexing decision to republish the originally reported–and unreliable–findings from the trial of the Lightning Process. She did not respond. This morning I sent the letter again, with more individual signatories along […] (Source: virology blog)
Source: virology blog - November 22, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs