Trial By Error: My Latest Letter on The Lightning Process Study
By David Tuller, DrPH Those responsible for publishing the dung heap known as the Lightning Process study have failed in their editorial obligations. They continue to disseminate findings that have been tarted up for publication and have taken no further action to correct the medical literature in the eleven months since posting an obscurely located […] (Source: virology blog)
Source: virology blog - May 22, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: The Lightning Process Is “ Effective ” ? Really?
By David Tuller, DrPH BMJ seems to be in a state of paralysis over what to do about the Lightning Process study. The fact that this study was cited positively last month in a major review of pediatric CFS/ME (as the review called the illness) raises the stakes all around. The other day I sent […] (Source: virology blog)
Source: virology blog - May 20, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: My Follow-Up Letter to the British Journal of General Practice
By David Tuller, DrPH Two weeks ago, I exchanged e-mails with Professor Roger Jones, editor of the British Journal of General Practice. I asked him to correct a false statement in an editorial about the cost of so-called medically unexplained symptoms to the National Health Service. In response, he invited me to send in “one […] (Source: virology blog)
Source: virology blog - May 20, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 548: Mice, shrews, and caterpillars
Vincent travels to the European Congress of Virology in Rotterdam and with local co-host Marion Koopmans speak with Martin Beer, Stephan Gunther, and Vera Ross about their careers and their work on Lassa virus, Borna virus, and insect viruses. Click arrow to play Download TWiV 548 (43 MB .mp3, 72 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show […] (Source: virology blog)
Source: virology blog - May 19, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology baculovirus Borna virus encaphalitis European Congress of Virology Lassa virus metagenomics nigeria outbreak response transplant recipient viral virus behavior modification viruses zombie caterpillar Source Type: blogs

Trial By Error: A Plea to Fiona Godlee on a Familiar Topic
By David Tuller, DrPH On Wednesday, I sent the following to Dr Fiona Godlee, editorial director of BMJ. The topic, once again, was the ethically and methodologically challenged Lightning Process study, which was published two years ago in Archives of Disease in Childhood, a BMJ journal. My letter was prompted by the recent appearance of […] (Source: virology blog)
Source: virology blog - May 16, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Michael Rossmann, 88
Michael Rossmann, a leader in the use of X-ray crystallography and cry-electron microscopy to solve the structure of viruses, died on 14 May 2019 at the age of 88. I met Michael many times but had the good fortune to interview him during the preparation of the fourth edition of Principles of Virology (ASM Press). […] (Source: virology blog)
Source: virology blog - May 16, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information cry-electron microscopy interview Michael Rossman structural virology viral virus viruses X-ray crystallography Source Type: blogs

Trial By Error: A Crowdfunding Wrap-Up
By David Tuller, DrPH This wrap-up is almost two weeks late, but things keep cropping up! It goes without saying that I am extremely gratified by the support for my April crowdfunding on Berkeley’s in-house platform. The university received 1025 donations totally $103,283 for “Trial By Error.” Of those donations, the most–384–came from the UK. […] (Source: virology blog)
Source: virology blog - May 14, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 547: Upstate virology
Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses. Click arrow to play Download TWiV 547 (58 MB .mp3, 96 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - May 14, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology arbovirus DDX68 epitranscriptome flavivirus hepatitis C virus mosquito vector viral viruses West Nile virus zika virus Source Type: blogs

Trial By Error: My Most Recent Exchange with Bristol
By David Tuller, DrPH Last month, I sent Sue Paterson, Bristol University’s director of legal services, a couple of e-mails seeking answers to several questions. Those e-mails can be read here and here. I cc-d a few other people. On Friday, May 10, I received a response. This morning, I wrote back. I cc-d those […] (Source: virology blog)
Source: virology blog - May 13, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

A risky vaccine
by Gertrud U. Rey Dengue fever, caused by dengue virus (DENV), is of substantial public health significance in the tropics, where the virus is spread by Aedes mosquitoes. Last week the FDA announced its approval of a first vaccine for the prevention of dengue disease in endemic areas. The vaccine approved by the FDA is Dengvaxia, a […] (Source: virology blog)
Source: virology blog - May 9, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Commentary Gertrud Rey Information aedes aegypti antibody dependent enhancement dengue hemorrhagic fever dengue virus Dengvaxia vaccine viral viruses Source Type: blogs

Trial By Error: My Exchange with the British Journal of General Practice
By David Tuller, DrPH As I have reported, I recently sent a letter to the editor of the British Journal of General Practice. To my surprise, when I woke up this morning I had an e-mail from him. Below is that e-mail, followed by my response. ********** Dear Dr Tuller If you are certain that […] (Source: virology blog)
Source: virology blog - May 7, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: My Letter about MUS to the British Journal of General Practice
By David Tuller, DrPH Reuters reporter Kate Kelland informed me in January that my habit of routinely sending open letters to researchers and journals to expose what I consider to be bogus studies was “harassment,” according to those who perceive themselves as my victims. Whatever. I disagree that writing lots of letters about violations of […] (Source: virology blog)
Source: virology blog - May 6, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Hepatitis delta-like virus in birds and snakes
Hepatitis D virus is a unique human pathogen. With a circular, negative stranded RNA genome of ~1700 nucleotides, it is the smallest known human virus. Formation of the HDV particle depends on co-infection of cells with a helper virus, hepatitis B virus. Once thought to be specific for humans, related viruses have now been identified […] (Source: virology blog)
Source: virology blog - May 2, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information avian HDV circular RNA helper virus hepatitis b virus hepatitis D virus hepatitis delta virus satellite virus snake HDV viral viruses Source Type: blogs

Trial By Error: My Follow-Up Letter to Reuters
By David Tuller, DrPH Earlier this month, as I have reported, I sent a letter to the Reuters global editor for “ethics and standards” about my concerns relating to last month’s hit piece on ME/CFS patients and me. (I put those words in quotation marks because I have seen little in the reporting and publication […] (Source: virology blog)
Source: virology blog - April 30, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: My Latest Letter to Bristol ’ s Legal Department
By David Tuller, DrPH Today I sent the following e-mail to Sue Paterson, director of legal services at Bristol University. I cc-d several other people on the e-mail. ********** Dear Ms Paterson— Earlier this month, I sent you an e-mail to ask, among other questions, when Bristol University plans to finish its investigation of studies […] (Source: virology blog)
Source: virology blog - April 29, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Complementing neutralization of viruses by antibodies
Viral infection of vertebrates leads to the production of antibodies, and some of these can block virus infection by a process that is called neutralization. Antibodies can neutralize viral infectivity in a number of ways: they may impair virus entry into cells, and even cause degradation of the capsid in the cytoplasm. A newly discovered […] (Source: virology blog)
Source: virology blog - April 26, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information adenovirus antibody c1q C4 complement protein end-some neutralization of infectivity trim21 viral viruses Source Type: blogs

Trial By Error: Jennie Spotila on Collins ’ NIH Talk
By David Tuller, DrPH I’ve never spoken to Francis Collins, who heads the National Institutes of Health. He comes across as a decent, caring man, and by all accounts he is. That’s certainly how he came across in his remarks earlier this month at the NIH’s meeting on ME/CFS research. But anyone who runs the […] (Source: virology blog)
Source: virology blog - April 23, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Crowdfunding Week 3 Matching Grant
By David Tuller, DrPH Hey folks! As of now I am at 71% of my goal, with eight days to go. So far I have exactly 700 donations. It would be great to get closer to 1000, as in previous years. Today, Erica Verillo has generously offered to match any donations made through this Friday–up […] (Source: virology blog)
Source: virology blog - April 22, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Revisiting the Reuters Story
By David Tuller, DrPH After Reuters ran that PACE/CBT/GET propaganda piece last month, I sent an e-mail expressing two concerns to Kate Kelland, the reporter, and the two editors listed as having worked on the story. The first concern was that the story falsely said I published my investigation on the blog of a Berkeley […] (Source: virology blog)
Source: virology blog - April 21, 2019 Category: Virology Authors: David Tuller Tags: David Tuller ME/CFS Source Type: blogs

TWiV 544: Immunogaga
The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA. Click arrow to play Download TWiV 544 (65 MB .mp3, 108 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - April 21, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology adenovirus C4 protein complement IgG maternal antibodies neonatal antibodies placenta uncoating viral VirScan viruses Source Type: blogs

Immunize mother to protect baby
When we are born, our blood contains antibodies that we have inherited from our mothers. They are transferred across the placenta and provide protection from infection until IgG production begins around 15 weeks after birth. Can we exploit such antibody transfer by vaccinating pregnant mothers to protect newborns against infectious diseases that occur early after […] (Source: virology blog)
Source: virology blog - April 19, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antibody cord blood herpes simplex virus herpes vaccine IgG neonatal herpes passive immunization transplacental passage viral viruses Source Type: blogs

Trial By Error: A Reuters Update
By David Tuller, DrPH Last Sunday, I sent a letter expressing my concerns about Kate Kelland’s recent article to the appropriate person–the Reuters global editor for ethics and standards. After considering the issues, Reuters has decided to add my current academic title to the post and leave everything else as is. I appreciate the first […] (Source: virology blog)
Source: virology blog - April 18, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Crowdfunding, Week 2; and more Sharpe and Chalder
By David Tuller, DrPH As of this post, I have achieved 57% of my goal, with 542 donations and 15 days left to go. I think that’s pretty good! I’m optimistic about getting reasonably close to the amount I’m trying to raise. Folks at Berkeley certainly notice the success of my crowdfunding. It is an […] (Source: virology blog)
Source: virology blog - April 15, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 543: Stoned and senile
The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice. Click arrow to play Download TWiV 543 (65 MB .mp3, 108 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - April 14, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology alzheimer's disease amoebae dementia giant virus herpes simplex virus 1 histone horizontal gene transfer Medusavirus memory loss mouse model NCLDV neurodegereration reactivation viral viruses Source Type: blogs

An advocate for vaccines
by Gertrud U. Rey In 1998, a British doctor named Andrew Wakefield published a paper in the British journal The Lancet. In this paper, Wakefield implied that the measles, mumps, and rubella (MMR) vaccine may cause developmental disorders such as autism spectrum disorder (ASD). The paper received wide publicity, and subsequently, MMR vaccination rates began […] (Source: virology blog)
Source: virology blog - April 11, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information autism measles MMR mumps peter hotez rubella vaccines viral virus viruses Source Type: blogs

Trial By Error: My Latest Letter to Bristol
By David Tuller, DrPH Last month I wrote to the director of legal services at the University of Bristol seeking information about documents from a study conducted by investigators from the institution. The study, published by BMJ Open in 2011, was called “Unidentified Chronic Fatigue Syndrome/myalgic encephalomyelitis (CFS/ME) is a major cause of school absence: […] (Source: virology blog)
Source: virology blog - April 9, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Crowdfunding, Week 1
By David Tuller, DrPH As I figured, the crowdfunding slowed down dramatically last week after the initial rush, but in the last few days has experienced a bit of a lift. I’ve now topped $42,300 and have reached 44% of the goal. That’s pretty amazing! Many of the 420 donations are in the $10 to […] (Source: virology blog)
Source: virology blog - April 8, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 542: Inside Microbiotix
Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases. Click arrow to play Download TWiV 542 (40 MB .mp3, 65 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - April 7, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology adenovirus biotech cytomegalovirus drug development ebolavirus herpesvirus influenza Lassa virus Microbiotix small molecule drugs viral viruses Source Type: blogs

Avian influenza virus transmission experiments proceed, as they should
The decision by the US government to allow the resumption of experiments on aerosol transmission of avian influenza viruses has once again raised the hackles of some individuals who feel that the work is too risky. I disagree with their view on this work. Science reports that ‘Controversial lab studies that modify bird flu viruses […] (Source: virology blog)
Source: virology blog - April 5, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Commentary aerosol transmission avian influenza ferret fouchier gain of function H5N1 kawaoka viral virus viruses Source Type: blogs

Trial By Error: This Year ’ s US Clinician Summit
By David Tuller, DrPH The PACE trial and other unacceptable studies from the CBT/GET ideological brigades have had an enormous impact around the world. Luckily, in the US at least, momentum seems to have finally shifted away from this bogus treatment paradigm. The shift, while welcome and long overdue, does not automatically mean more effective […] (Source: virology blog)
Source: virology blog - April 2, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: My Berkeley Crowdfunding Appeal
By David Tuller, DrPH And here’s the crowdfunding link without any preamble: https://crowdfund.berkeley.edu/project/14941 And here’s what I’ve written in the appeal: So it’s been a year since the last crowdfunding campaign for Trial By Error–my investigative reporting and public health project. While Trial By Error began 3+ years ago as an in-depth look at the […] (Source: virology blog)
Source: virology blog - April 1, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: April is Berkeley Crowdfunding Month!
By David Tuller, DrPH Today is the official “hard launch” of Berkeley’s month of crowdfunding. The “soft launch” phase began last Wednesday, when the site actually went live. I posted the Trial By Error page that day on Facebook. As of this posting, I’ve already reached 27% of my goal, with almost $26,000 in donations! […] (Source: virology blog)
Source: virology blog - April 1, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: A Bit More on Kaiser Permanente
By David Tuller, DrPH BerkeleyWellness.com has posted a version of my interview with Dr Steve Olson. He’s the Kaiser Permanente guy who is revamping the health system’s approach to ME/CFS, which is what they are now calling the disease. Dr Olson is planning to attend this week’s research gathering at the National Institutes of Health, […] (Source: virology blog)
Source: virology blog - April 1, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 541: Cloaking devices
The TWiVers present mitoviruses, which infect mitochondria, and how quasi-enveloped hepatitis A virus gets naked again. Click arrow to play Download TWiV 541 (54 MB .mp3, 89 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - March 31, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology endocytosis ESCRT pathway hepatitis a virus Leviviridae lysosome mitochondria mitovirus Narnaviridae Narnavirus quasi-enveloped viral viral uncoating viruses Source Type: blogs

Viruses that infect mitochondria
A listener of the science podcast This Week in Virology asked in 2010 whether there are viruses that infect mitochondria: Is there a virus that infects mitochondria? It’s an organelle that has its own genetic material and polymerase, so it could replicate a virus. Does the mitochondrial double membrane and the cell membrane impose a […] (Source: virology blog)
Source: virology blog - March 29, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information fungus mitochondria mitovirus Narnavirus plant RNA polymerase viral viruses Source Type: blogs

Trial By Error: The CDC ’ s Pathetic Response to Reuters
By David Tuller, DrPH The recent Reuters article about the illness, or cluster of illnesses, variously called CFS, ME, CFS/ME and ME/CFS was problematic for many reasons. One of them was the information included from the US Centers for Disease Control and Prevention. In explaining why the CDC dropped its longstanding recommendations for cognitive behavior […] (Source: virology blog)
Source: virology blog - March 25, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 540: Wascally wiruses
The TWiVstars reveal the diversity of herpes simplex virus type 2 in a neonatal population, and parallel adaptation of rabbits in three countries to myxoma virus. Click arrow to play Download TWiV 540 (66 MB .mp3, 109 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! (Source: virology blog)
Source: virology blog - March 24, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology adaptation comparative genomics genome sequence herpes simplex virus herpes simplex virus type 2 human herpesvirus 2 minor variants myxoma virus neonatal neonate neurovirulence parallel evolution poxvirus Source Type: blogs

Rabbits and viruses: An iconic example of natural selection
When viruses are introduced into a new population, selection pressures can lead to evolution of both pathogen and host. The pathogen must adapt to a new host, while the latter can become resistant to infection, leading to an arms race. An archetypal example of such host-pathogen evolution is illustrated by the attempt to control rabbit […] (Source: virology blog)
Source: virology blog - March 22, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information australia evolution myxoma virus natural selection rabbit viral viruses Source Type: blogs

Trial By Error: My Letter to Kate Kelland
By David Tuller, DrPH This morning I sent the following e-mail to Kate Kelland, the Reuters reporter who wrote last week’s story about horrible patients and horrible me, and about how all this horribleness is affecting Professor Michael Sharpe. I cc’d Professor Racaniello and the two Reuters editors listed on the story. ********** Hi, Kate– […] (Source: virology blog)
Source: virology blog - March 18, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: My Letter to Professor Hotopf About Bristol ’ s School Absence Study
By David Tuller, DrPH Matthew Hotopf is a professor of general medicine psychiatry at King’s College London. He served as a peer-reviewer for a study by Bristol University investigators that was published in BMJ Open in 2011. The study involved whether school absences could be used to identify cases of diagnosed CFS/ME (as the study […] (Source: virology blog)
Source: virology blog - March 18, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 539: Multitudes contain me
The TWiV hosts present two potentially seminal papers, on long-distance chemoattraction of a host by a chlorovirus, and replication of a nanovirus across multiple cells in a plant. Click arrow to play Download TWiV 539 (62 MB .mp3, 102 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - March 17, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology algae chemical lure chemotaxis chlorovirus genome segment multicellular replication multipartite virus nanovirus Paramecium ssDNA viral viruses zoochlorellae Source Type: blogs

The London Patient
by Gertrud U. Rey Timothy Ray Brown, also known as the Berlin patient (reviewed in a previous post), was the only person ever to be cured of HIV/AIDS. Until last week. In a report published in the journal Nature, a group of investigators announced the cure of a second HIV-positive patient (designated the “London patient”). In the […] (Source: virology blog)
Source: virology blog - March 14, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Gertrud Rey Information AIDS bone marrow transplant CCR5 German patient HIV-1 London patient viral virus viruses Source Type: blogs

Trial By Error: Cochrane ’ s Report on Courtney ’ s Complaint
By David Tuller, DrPH Update: When I posted earlier today, I also meant to update what was happening with the exercise review. On March 8, Cochrane announced, through a notice appended to the review, that the authors would submit another revision in May. (Cochrane has already rejected a previous revision submitted last fall.) That is […] (Source: virology blog)
Source: virology blog - March 12, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Kaiser Permanente Changes Course
By David Tuller, DrPH Over the years, I’ve slammed U.S. medical and health care institutions that have championed the GET/CBT treatment paradigm for the illness or cluster of illnesses variously known as ME, CFS, ME/CFS or CFS/ME. I have done this both before and after the U.S. Centers for Disease Control and Prevention removed its […] (Source: virology blog)
Source: virology blog - March 12, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 538: An Iowa caucus of viruses
TWiV travels to the University of Iowa to speak with Wendy Maury and Stanley Perlman about their research on Ebolavirus entry and coronavirus pathogenesis. Click arrow to play Download TWiV 538 (37 MB .mp3, 62 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - March 10, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology ebolavirus MERS coronavirus mouse hepatitis virus SARS coronavirus TIM-1 viral virus entry viruses Source Type: blogs

A fatal attraction
Viruses have no intrinsic means of locomotion, but because of their small size their movement can be driven by Brownian motion. Propagation of viruses is dependent on essentially random encounters with potential hosts and host cells. An exception appears to be chloroviruses, which can attract their host from a distance. Chloroviruses are large icosahedral viruses […] (Source: virology blog)
Source: virology blog - March 8, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information algae chemotaxis chlorovirus Paramecium protozoa viral viruses Source Type: blogs

Trial By Error: Stupid Studies
By David Tuller, DrPH Boy, it’s hard to keep up with all the stupid studies coming out! But that’s no reason not to take a look at a couple of them. (In both cases, I’m just making a few comments. Much more could be said about each of these studies. You can read more about […] (Source: virology blog)
Source: virology blog - March 7, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Who Has the School Study Documents?
By David Tuller, DrPH I first wrote about BMJ Open’s 2011 school absence study in August, 2017. The investigators, all from Bristol University, exempted the study from ethical review on the grounds that it qualified as “service evaluation.” The study included a hypothesis, generalizable conclusions and in-person interviews with participants. Since these are all features […] (Source: virology blog)
Source: virology blog - March 4, 2019 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 537: Boundary issues
The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses. Click arrow to play Download TWiV 537 (63 MB .mp3, 104 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - March 3, 2019 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology bacteriophage bat HLA influenza virus MHC II protein receptor ribosomal protein ribosome ribosome hibernation factor viral virus entry viruses Source Type: blogs

Cancer-killing viruses
by Gertrud Rey Although cancer therapies have improved dramatically in recent years, the main options for treating cancer still consist of surgery, chemotherapy, and radiation therapy. This limitation is a problem for aggressive cancers like glioblastoma multiforme (GBM), brain cancers which are typically resistant to traditional therapies. GBM is a high grade glioma, an aggressive […] (Source: virology blog)
Source: virology blog - February 28, 2019 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Gertrud Rey Information glioblastoma multiforme herpes simplex virus viral viral oncotherapy viruses Source Type: blogs