An inborn error of innate immunity leading to severe rhinovirus infections
When a human population is exposed to a pathogenic virus, the outcomes among individuals may include asymptomatic, mild, severe, or no infection. Multiple parameters control these responses, including the amount of virus taken up, the age of the host, general health status, nutrition, and more. With the advent of whole exome sequencing we can now […] (Source: virology blog)
Source: virology blog - December 13, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information IFIH1 IFN inborn error innate immune sensor MDA5 missense respiratory infection rhinovirus viral viruses Source Type: blogs

Trial By Error: The View From Norway
By David Tuller, DrPH I spent the last week of November in Oslo. The Norwegian ME Association invited me to give a couple of talks and have some meetings with public health officials. The city was charming, even if dark and overcast at this time of year. Not surprisingly, the same tussle taking place over […] (Source: virology blog)
Source: virology blog - December 12, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 524: Slicing and dicing with Raul
Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: […] (Source: virology blog)
Source: virology blog - December 12, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology argonaute cricket dicer drosophila insect proteasome RNA interference rnai ubiquitin viral virus viruses Source Type: blogs

Trial By Error: And Cochrane Makes Another Move …
By David Tuller, DrPH Yet another interesting development has taken place at Cochrane—and this new development again suggests that things there might be moving in the right direction. On Friday, the organization withdrew a protocol for what is called an “individual patient data” review of exercise therapy for the illness it has referred to as […] (Source: virology blog)
Source: virology blog - December 10, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 523: Virology in Z ürich
At the University of Zürich, Vincent speaks with virologists Cornel Fraeful, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; […] (Source: virology blog)
Source: virology blog - December 9, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology aav adenovirus adenovirus-associated virus genome wide screen helper virus influenza virus viral virus entry viruses Source Type: blogs

Trial By Error: How BMJ Enabled Bristol ’ s Ethics Exemptions
By David Tuller, DrPH Earlier today, I sent the following e-mail to Dr Fiona Godlee, editorial director of BMJ. I cc’d Carol Monaghan MP, Darren Jones MP, and Nicky Morgan MP. I also cc’d Teresa Allen of the Health Research Authority. ********** Dear Dr. Godlee— As you know, I have spent some time criticizing a […] (Source: virology blog)
Source: virology blog - December 4, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Some Good News on Cochrane
By David Tuller, DrPH In what can only be characterized as a welcome surprise, Cochrane has rejected the revision of a 2014 review of exercise treatments for chronic fatigue syndrome, stating that the work does not meet the organization’s “quality standards.” Cochrane revealed the decision late Friday in a statement appended to the review, which […] (Source: virology blog)
Source: virology blog - December 3, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 522: Readers of the lost ORF
The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span […] (Source: virology blog)
Source: virology blog - December 2, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology Source Type: blogs

The lost picornavirus ORF
For over 50 years the RNA genome of picornaviruses (illustrated below for poliovirus) was thought to be translated into a single, long polyprotein. All this time a very small upstream open reading frame (uORF) has gone undetected – until now. Analysis of over 3000 picornavirus genomes revealed a small ORF, beginning with an AUG codon, […] (Source: virology blog)
Source: virology blog - November 30, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information echovirus membrane vesicles open reading frame picornavirus poliovirus polyprotein uORF viral viruses Source Type: blogs

TWiV 521: Spitting in the Allee
Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span> Click […] (Source: virology blog)
Source: virology blog - November 25, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology Acanthamoeba castellani Allee effect giant virus Mollivirus sibericum multiplicity of infection NCLDV nucleo-cytoplasmic virus saliva viral virus aggregation viruses vsv Source Type: blogs

Paul Has Measles
Susana López, Martha Yocupicio, Selene Zárate, virologists from Mexico, together with graphic illustrator Eva Lobatón, have teamed up to produce Paul Has Measles, a children’s book about viruses and vaccines. Paul Has Measles is available in English (download link) or Spanish (download link). Please share! (Source: virology blog)
Source: virology blog - November 21, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology children book measles vaccines viral virus viruses Source Type: blogs

Trial By Error: Some Thoughts About NICE
By David Tuller, DrPH The UK’s National Institute for Health and Care Excellence (NICE), which develops clinical guidelines for a range of medical conditions, is currently selecting a committee to develop a new guidance for the illness it refers to as myalgic encephaloymyelitis/chronic fatigue syndrome (ME/CFS). The new guidance will replace one written in 2007, […] (Source: virology blog)
Source: virology blog - November 19, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 520: This old mouse
The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice.  Click arrow to play Download TWiV 520 (70 MB .mp3, 116 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show […] (Source: virology blog)
Source: virology blog - November 18, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology chronic kidney disease clinical trial HA stalk vaccine immunocompromised immunosufficient influenza kidney fibrosis parvovirus peptide tubulointerstitial nephropathy universal influenza vaccine viral viruses Source Type: blogs

Leaving Koch behind
For the past 40 years, certain laboratory mice in Australia and the US have been unexpectedly dying in middle age, but the cause has remained elusive. A novel member of the parvovirus family appears to be the culprit. These unexpected deaths of laboratory mice are caused by kidney disease, as these organs appear shrunken and […] (Source: virology blog)
Source: virology blog - November 16, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information chronic kidney disease inclusion body nephropathy interstitial fibrosis intranuclear inclusion bodies koch's postulates parvovirus tubular necrosis viral viruses Source Type: blogs

Trial by Error: Video of October Newry Talk, with Brian Hughes
By David Tuller, DrPH Here’s a video of back-to-back presentations from last month in Newry, Northern Ireland. On October 2, Brian Hughes, a professor of psychology at the National University of Ireland, Galway, and I both spoke at an event organized by Hope For ME & Fibro Northern Ireland. The title of the event: “The […] (Source: virology blog)
Source: virology blog - November 14, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: How Bristol Investigators Avoided Ethical Review
By David Tuller, DrPH I have written many posts about BMJ Open’s 2011 school absence study, which reported that school absence records could be useful in identifying children with chronic fatigue syndrome. However, for reasons not yet adequately explained, the investigators exempted the study from ethical review on the grounds that it qualified as “service […] (Source: virology blog)
Source: virology blog - November 12, 2018 Category: Virology Authors: David Tuller Tags: David Tuller ME/CFS Source Type: blogs

Trial By Error: How to Avoid Ethical Review
By David Tuller, DrPH I have written many posts about BMJ Open’s 2011 school absence study,   which reported that school absence records could be useful in identifying children with chronic fatigue syndrome. However, for reasons not yet adequately explained, the investigators exempted the study from ethical review on the grounds that it qualified as […] (Source: virology blog)
Source: virology blog - November 12, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 519: Fishing for viruses in senile
The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer’s Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles.  Click arrow to play Download TWiV 519 (58 MB .mp3, 96 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 11, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology acyclovir alzheimer's disease amyloid plaque antiviral beta amyloid herpes simplex virus HSV-1 senile dementia viruses Source Type: blogs

Herpes simplex virus and Alzheimer ’s disease
Alois Alzheimer was the first to propose that an infection might play a role in the disease named after him. Herpes simplex virus type 1 (HSV-1) has been most frequently linked to Alzheimer’s Disease (AD), and a clinical trial is in progress to determine if antivirals ameliorate its development. What is the evidence that HSV-1 […] (Source: virology blog)
Source: virology blog - November 9, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Commentary Information alzheimer's disease amyloid beta amyloid plaque antiviral clinical trial herpes simplex virus viruses Source Type: blogs

Trial By Error: An Australian Exchange with Professor Sharpe
By David Tuller, DrPH Below is an exchange between members of the Australian ME/CFS community and Professor Michael Sharpe. The open letter from patients and advocates was prompted by a tweet this week from Professor Sharpe that many considered offensive. He has since deleted it. This post includes the initial tweet as well as the […] (Source: virology blog)
Source: virology blog - November 8, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Yet Another Letter About the Lightning Process Study
By David Tuller, DrPH This morning I sent the following letter to Fiona Godlee, editor-in-chief of The BMJ and editorial director of BMJ. I cc-d Carol Monaghan MP, Darren Jones MP, and Nicky Morgan MP. ********** Dear Dr. Godlee— More than a dozen years ago, a group of leading medical journals agreed that requiring clinical […] (Source: virology blog)
Source: virology blog - November 7, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 518: Hershey ’ s viruses
Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick Buchkovich and Leslie Parent about their careers and their work on human cytomegalovirus and retroviruses.  Click arrow to play Download TWiV 518 (53 MB .mp3, 86 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become […] (Source: virology blog)
Source: virology blog - November 4, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology ESCRT pathway exosome Gag protein genome packaging HCMV HIV-1 human cytomegalovirus late domain nuclear experience retrovirus rous sarcoma virus viral viruses Source Type: blogs

Viral Defenses In Plantae
By Gertrud U. Rey Post-transcriptional gene silencing (PTGS) is an RNA regulation pathway in eukaryotes that depends on the presence of double stranded RNA (dsRNA) in the cytoplasm of cells. As stated by Nels Elde in TWiEVO 8, dsRNA in the cytoplasm has an effect synonymous to “blood in the water” for the innate immune […] (Source: virology blog)
Source: virology blog - November 1, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Gertrud Rey Information decapping enzyme dsRNA in plantae P bodies plant virus post-transcriptional gene silencing siRNA viral viruses Xrn1 Source Type: blogs

TWiV 517: Just in time for Halloween
Brianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC.  Click arrow to play Download TWiV 517 (48 MB .mp3, 79 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! […] (Source: virology blog)
Source: virology blog - October 28, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology Africa asymptomatic infection bat virus bat-borne mumps virus Bombali virus ebolavirus fruit bat insectivorous bat neurotropism neurovirulence viral viruses zoonosis zoonotic potential Source Type: blogs

Trial By Error: Three Years On …
By David Tuller, DrPH Three years ago this month, Virology Blog published my 15,000-word investigation of the PACE trial, so this seems like a good time for a bit of reflection. I certainly didn’t expect this saga to drag on this long. I’ve kept at it mainly because of the UK academic and medical establishment’s […] (Source: virology blog)
Source: virology blog - October 28, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

A new drug for influenza
A new drug has been approved by the US Food and Drug Administration for the treatment of influenza. Called Xofluza (baloxavir carboxyl), it is the first influenza drug approved in 20 years with a new mechanism of action. How does Xofluza work? Influenza virus particles contain (-) RNAs, which means that they cannot be translated […] (Source: virology blog)
Source: virology blog - October 25, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antiviral Baloxavir carboxyl cap dependent endonuclease influenza oseltamivir virus viruses Xofluza Source Type: blogs

Trial By Error: Where ’ s My Apology, BMJ Open?
By David Tuller, DrPH This morning I sent the following e-mail to Dr Fiona Godlee, the editor-in-chief of The BMJ and editorial director of BMJ. I cc’d Professor Vincent Racaniello, the host of Virology Blog, and Carol Monaghan MP, who sits on the House of Commons Health and Technology Committee. ********** Dear Dr Godlee— I […] (Source: virology blog)
Source: virology blog - October 24, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

A Statement in Support of Cochrane
Cochrane has decided to temporarily withdraw a review of exercise therapies for the illness variously known as ME, CFS, ME/CFS and CFS/ME. The review reported that exercise therapy is effective in treating the illness—a finding that has provided unwarranted support for recommendations that patients should undergo the intervention known as graded exercise therapy. Yet Cochrane […] (Source: virology blog)
Source: virology blog - October 23, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 516: HUSH little virus, don ’ t you transcribe
Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: […] (Source: virology blog)
Source: virology blog - October 21, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology chromatin HIV human immunodeficiency virus HUSH complex LINE-1 promoter proteasome provirus siv transcriptional repression viral viruses Vpr Vpx Source Type: blogs

My letter to organizer of 4th Columbia Psychosomatics Conference
Yesterday I sent an email to Dr. Landa who had previously written to David Tuller about the 4th Columbia Psychosomatics Conference (link to David’s post). Like David, I was unhappy about Dr. Landa’s note so I decided to write her and see if she might respond better to a Columbia colleague. Apparently my faith in […] (Source: virology blog)
Source: virology blog - October 19, 2018 Category: Virology Authors: Vincent Racaniello Tags: Commentary ME/CFS Columbia Psychosomatics Conference david tuller Per Fink Source Type: blogs

Trial By Error: A Reminder about Saturday ’ s Columbia Protest
By David Tuller, DrPH In my earlier post about this issue, I accurately credited #MEAction but did not specifically make clear that Saturday’s demonstration has been organized by the movement’s New York arm. I apologize for the oversight. So here’s an official New York #MEAction announcement about the event. I would be there tomorrow if […] (Source: virology blog)
Source: virology blog - October 19, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Cochrane Decides to Withdraw Flawed Exercise Review
By David Tuller, DrPH *The headline has been changed to indicate that Cochrane has decided to withdraw the review but had not yet done so at time of posting. Cochrane has decided to withdraw, at least for now, its fatally flawed review of exercise treatments for ME/CFS—or CFS, as the review calls the illness. This […] (Source: virology blog)
Source: virology blog - October 19, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Cochrane Withdraws Flawed Exercise Review
By David Tuller, DrPH Cochrane has decided to withdraw, at least for now, its fatally flawed review of exercise treatments for ME/CFS—or CFS, as the review calls the illness. This review, which reported that graded exercise therapy was an effective treatment, was first published in 2014 and republished last year. The more recent version included […] (Source: virology blog)
Source: virology blog - October 19, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

A cell RNA that regulates innate immunity
All immune responses, from intrinsic to adaptive, need to be regulated – if left on indefinitely they will damage the host. The innate immune response is no exception, and a cellular RNA has been identified that binds to a sensor of viral RNA and regulates the production of interferon (IFN). The innate immune response, an […] (Source: virology blog)
Source: virology blog - October 18, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information dsRNA IFN innate immunity interferon lncRNA long non-coding RNA RIG-I viral virus viruses Source Type: blogs

ME/CFS is not a psychosomatic illness
W. Ian Lipkin, Director of the Center for Infection and Immunity and the Center for Solutions for ME/CFS at Columbia University, has written the following letter several days before the Fourth Annual Conference on Psychosomatics at Columbia University this weekend. The original letter can be found at this link. 18 October 2018 Dear Colleagues and Friends, The […] (Source: virology blog)
Source: virology blog - October 18, 2018 Category: Virology Authors: Vincent Racaniello Tags: ME/CFS chronic fatigue syndrome columbia university conference psychosomatic w ian lipkin Source Type: blogs

Trial By Error: The Psychosomatic Conference ’ s Pathetic Response
By David Tuller, DrPH After I posted yesterday’s blog about Per Fink’s upcoming appearance at the fourth annual Columbia Psychosomatic Conference being held this weekend, I received the following e-mail from Columbia’s Alla Landa. She is an assistant professor of “clinical psychology in psychiatry”–whatever that means–and director of the conference. I found her note unsatisfactory […] (Source: virology blog)
Source: virology blog - October 17, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Per Fink in New York
By David Tuller, DrPH Someone uninformed or stupid or maybe both decided to invite Danish physician Per Fink to present at a conference on so-called psychosomatic medicine being held this weekend at Columbia University. Fink—I won’t dignify him by using an honorific–is a scary guy. He should never have been provided with this prestigious platform—in […] (Source: virology blog)
Source: virology blog - October 16, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 515: When virus is in retrograde
The TWiV team notes the passing of Tom Steitz, an outbreak of acute flaccid myelitis in the US, a continuing Ebola virus outbreak in DRC, respiratory vaccinia due to inhalation of ground up rabbit skin, and how a human papillomavirus capsid protein directs virus-containing endosomes towards the nucleus. 
Source: virology blog - October 14, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology capsid protein L2 cell penetrating peptide DRC ebola virus HPV human papillomavirus outbreak rabbit skin respiratory vaccinia retrograde transport retromer Tom Steitz trans-Golgi network vaccine vaccinia Source Type: blogs

A Hippocratic oath for scientists
At the First Annual Lab Coat Ceremony for Ph.D. and MD/Ph.D. students at Icahn School of Medicine at Mount Sinai, at which I delivered the Keynote Address, the students and their mentors were asked to recite oaths pledging their dedication to the field. Such oaths have been called ‘Hippocratic oaths for Scientists’, similar to the […] (Source: virology blog)
Source: virology blog - October 11, 2018 Category: Virology Authors: Vincent Racaniello Tags: Commentary Hippocratic oath for scientists Icahn School of Medicine at Mt. Sinai lab coat ceremony MD/Ph.D. students Source Type: blogs

Influenza vaccine is safe for those with egg allergies
With the influenza season approaching in the northern hemisphere, vaccination is a means of preventing infection. If you have egg allergies, you no longer have to worry about receiving influenza vaccine. Because most influenza vaccines are grown in embryonated chicken eggs, and may contain residual egg protein, their use in individuals with egg allergy has […] (Source: virology blog)
Source: virology blog - October 10, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information egg allergy influenza vaccine viral virus viruses Source Type: blogs

Trial By Error: My First Post on the IAPT Program
By David Tuller, DrPH Since 2008, the English arm of the National Health Service has been rolling out a program called Improving Access to Psychological Therapies, or IAPT. More than 900,000 people now receive IAPT services annually. This program arose out of the notion that many people were suffering from untreated depression, anxiety and other psychiatric […] (Source: virology blog)
Source: virology blog - October 10, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: My Latest Letter to Archives of Disease in Childhood
By David Tuller, DrPH I sent the following e-mail today to Dr Nick Brown, the editor-in-chief of Archives of Disease in Childhood, the journal that published the Lightning Process study a year ago. I cc’d Dr Fiona Godlee, editorial director of BMJ, which publishes Archives. ********** Dear Dr Brown— As you know, I have been […] (Source: virology blog)
Source: virology blog - October 8, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 514: Staying below the ADAR
The TWiVumvirate reviews this years crop of Nobel Prizes, and how cells prevent leakage of mitochondrial double-stranded RNA into the cytoplasm, which would otherwise lead to the production of interferon. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: […] (Source: virology blog)
Source: virology blog - October 7, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology ADAR1 Alu checkpoint blockade CTLA-4 degradosome directed evolution dsRNA helicase IFN innate immunity MDA5 mitochiondria mutagenesis Nobel Prize PD-1 phage display RNA sensor type 1 interferonopat Source Type: blogs

Mitochondrial double-stranded RNA is dangerous
Mitochondria are descended from bacteria that invaded cells 1.5 billion years ago and never left. The mitochondrial genome is like that of bacteria: circular double-stranded DNA, only smaller. And just like the genome of bacteria, RNA can be made from both strands of mitochondrial DNA – which results in the formation of dsRNA. Fortunately there […] (Source: virology blog)
Source: virology blog - October 4, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information dsRNA innate immunity interferon interferonopathy MDA5 mitochondria viral virus viruses Source Type: blogs

Trial By Error: The CFS/ME Research Collaborative Conference
By David Tuller, DrPH So I attended the CFS/ME Research Collaborative conference two weeks ago in Bristol. The two-day event was a refreshingly PACE-free zone–as far as I could tell, I was the only person who mentioned that piece of crap in public comments. (Although I wasn’t on the schedule, CMRC vice chair Chris Ponting, […] (Source: virology blog)
Source: virology blog - October 1, 2018 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 513: Double-stranded in Belgium
From the 13th International Symposium on dsRNA viruses in Belgium, Vincent speaks with Harry Greenberg about his career and his work on rotaviruses, noroviruses, hepatitis B virus, and influenza virus. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; width: […] (Source: virology blog)
Source: virology blog - September 30, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology gastroenteritis Harry Greenberg hepatitis b virus norovirus rotavirus vaccine viral viruses Source Type: blogs

A cell protein that synthesizes an antiviral ribonucleotide
Some antiviral drugs, like acyclovir for treatment of herpes simplex virus infections, are chain terminators that block RNA or DNA synthesis. They are modified nucleotides that can be incorporated into a growing RNA strand, but no additional nucleotides can be added. Amazingly, a cell protein has been found that can synthesize antiviral chain terminators. Viperin* […] (Source: virology blog)
Source: virology blog - September 27, 2018 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information chain terminator CTP ddhCTP IFN ISG nucleoside polymerase rna synthesis viperin viral virus viruses Source Type: blogs

Trial By Error: The Open Letter to Netflix about Afflicted
By David Tuller, DrPH Last week, more than three dozen advocates for people with chronic illnesses signed an open letter to Netflix protesting Afflicted, a multi-part documentary. The open letter was posted on Medium. I have posted it below. (I have added my name to the list of signatories; I meant to sign on beforehand […] (Source: virology blog)
Source: virology blog - September 24, 2018 Category: Virology Authors: David Tuller Tags: David Tuller ME/CFS Source Type: blogs

TWiV 512: Flexuous SUMO wrestlers
Anne Simon joins the TWiV team to talk about plant viruses, including plum pox virus that devastates nut and stone fruit trees, and a geminivirus protein that regulates viral DNA synthesis. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span><span data-mce-type=”bookmark” style=”display: inline-block; […] (Source: virology blog)
Source: virology blog - September 23, 2018 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology dna replication geminivirus papaya ringspot virus PCNA plant virus plum pox virus potyvirus recombination rep protein SUMO viral viruses Source Type: blogs

CRISPR-ing HIV-1
By Gertrud U. Rey Although antiretroviral therapy (ART) has been highly effective at controlling HIV-1 viral loads in the bloodstream of infected individuals, the virus remains latent in infected cells and starts replicating within a couple of weeks upon termination of therapy. The discovery of CRISPR/Cas9 gene editing technology has provided renewed hope for alternative […] (Source: virology blog)
Source: virology blog - September 20, 2018 Category: Virology Authors: Vincent Racaniello Tags: Gertrud Rey CRISPR-Cas9 gene therapy HIV-1 latent reservoir lentivirus provirus excision vector viral virology viruses Source Type: blogs