Trial By Error: Professor Chalder Messes Up Again in New Paper on CFS and Employment Outcomes
By David Tuller, DrPH The discredited PACE trial of psychological and behavioral interventions for chronic fatigue syndrome (CFS) included four objective outcomes—a six-minute walking test, a step-test for fitness, employment/educational status, and whether the person was receiving social benefit. All four outcomes failed to match the positive reports on the subjective measures of fatigue and […] (Source: virology blog)
Source: virology blog - December 8, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized chalder PACE Source Type: blogs

Trial By Error: Lightning Process Star Complains About NICE; Struthers Nudges Cochrane to Keep Up
By David Tuller, DrPH Another Anti-Science Campaigner Takes Aim at NICE The anti-science zealots do not give up easily. Now Live Landmark, the Norwegian Lightning Process practitioner, has written an opinion piece blasting the new evidence-based guidelines for ME/CFS from the National Institute for Health and Care Excellence (NICE). I assume she is not just […] (Source: virology blog)
Source: virology blog - December 3, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized cochrane Landmark Lightning Process NICE struthers Source Type: blogs

The Esperanza Patient
This post describes the case of a woman who appears to have been naturally cured of her HIV infection. (Source: virology blog)
Source: virology blog - December 2, 2021 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey AIDS AIDS cure Antiretroviral therapy APOBEC3F APOBEC3G Berlin patient ccr5 receptor CD4 elite controller HIV hiv reservoir HIV-1 infection London patient provirus replication sterilizing cure Source Type: blogs

TWiV 835: Giving thanks for antibodies
TWiV reviews why children should be vaccinated against COVID-19, increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated but not recovered individuals, and immune correlates of protection from the mRNA-1273 vaccine efficacy trial. Click arrow to playDownload TWiV 835 (59 MB .mp3, 99 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at […] (Source: virology blog)
Source: virology blog - November 28, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antibody coronavirus COVID-19 immune correlate of protection pandemic SARS-CoV-2 vaccine viral viruses Source Type: blogs

TWiV 834: COVID-19 clinical update #90 with Dr. Daniel Griffin
In COVID-19 clinical update #90, Dr. Griffin covers FDA expansion for booster doses, 3 more at home antigen tests approved by FDA, immune correlates analysis of mRNA-1273 vaccine, risk for stillbirth, PROVENT prophylaxis trial results, fluvoxamine recommendations, advice on molnupiravir, automated text messaging service for monitoring illness, and long COVID-19 after vaccination and infection. Click […] (Source: virology blog)
Source: virology blog - November 28, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 inflammation monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs

Trial By Error: An Interview with Adam Lowe, a Member of the NICE Guideline Committee for ME/CFS
By David Tuller, DrPH Adam Lowe, a patient, was one of five lay people on the committee pulled together by Britain’s National Institute for Health and Care Excellence to work on the new ME/CFS guideline. He and I spoke recently on Zoom about his role in the process. (Source: virology blog)
Source: virology blog - November 28, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Adam Lowe NICE Source Type: blogs

TWiV 833: Grand theft kinesin
TWiV reviews Michael Worobey’s dissection of the early COVID-19 cases in Wuhan, and the discovery that herpesviruses assimilate cellular kinesin to produce motorized virus particles. Click arrow to playDownload TWiV 833 (77 MB .mp3, 128 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 25, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology COVID-19 herpesvirus Huanan Market kinesin motor microtubule pandemic SARS-CoV-2 viral viruses Wuhan Source Type: blogs

TWiV 832: Heavy metal flu fighters
TWiV reviews the vials labeled smallpox that were not, re-emergence of enterovirus D68 in Europe, efficacy of inactivated SARS-CoV-2 vaccine, and cellular correlates of protection for an oral influenza virus vaccine. Click arrow to playDownload TWiV 832 (77 MB .mp3, 128 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 21, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology adenovirus vector adjuvant correlate of protection Covaxin COVID-19 inactivated vaccine influenza influenza oral vaccine mass cytometry pandemic SARS-CoV-2 smallpox vaccine efficacy vaccinia virus viral Source Type: blogs

TWiV 831: COVID-19 clinical update #89 with Dr. Daniel Griffin
In COVID-19 clinical update #89, Dr. Griffin reviews upcoming meeting on FDA emergency use authorization for molnupiravir, 25% of US cases in children, reinfection associates with presence of antibodies, national surveillance for acute flaccid myelitis in the US, and monoclonal antibody treatment of infection in vaccinated, high-risk individuals. Click arrow to playDownload TWiV 831 (20 MB .mp3, […] (Source: virology blog)
Source: virology blog - November 21, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs

Trial By Error: New Paper From PACE Authors Repeats Bogus Arguments and Defenses
By David Tuller, DrPH The October 29th publication of the new guideline for ME/CFS from Britain’s National Institute for Health and Care Excellence (NICE) represented an enormous and humiliating repudiation of the PACE trial and the many related studies of cognitive behavior therapy (CBT) and graded exercise therapy (GET) as treatments for the illness. That […] (Source: virology blog)
Source: virology blog - November 20, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

TWiV 830: A culture of resistance
TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitrowould not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the […] (Source: virology blog)
Source: virology blog - November 18, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology coronavirus COVID-19 pandemic remdesivir resistance SARS-CoV-2 V(D)J recombination variant of concern viral viruses Source Type: blogs

Trial By Error: Some National Health Service Branches Fail to Respond to New NICE Guidelines for ME/CFS
By David Tuller, DrPH In late October, the UK’s National institute for Health and Care Excellence (NICE) released its new ME/CFS guideline, which specifically recommend against graded exercise therapy (GET) and a specialized form of cognitive behavior therapy (CBT). Last week, I wrote about how King’s College London continues to host a page on “CBT […] (Source: virology blog)
Source: virology blog - November 16, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized NICE Source Type: blogs

Trial By Error: Is Something Shifting at the Science Media Centre?
By David Tuller, DrPH For years, London’s Science Media Centre has fiercely promoted research into graded exercise therapy (GET) and cognitive behavior therapy (CBT) for the illness or cluster of illnesses variously referred to as chronic fatigue syndrome, myalgic encephaloymyelitis, CFS/ME, ME/CFS, and other names. Some of the prominent experts in this field have had […] (Source: virology blog)
Source: virology blog - November 15, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized chalder NICE Source Type: blogs

TWiV 829: Antiviral and cytotoxically empowered for COVID-19
A TWiV duo reviews how SARS-CoV-2 attacks the olfactory mucosa but spares the olfactory bulb, vaccination with BNT162b2 induces virus-specific stem cell memory T cells, and development of an oral protease inhibitor for the treatment of COVID-19. Click arrow to playDownload TWiV 829 (67 MB .mp3, 112 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 14, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology anosmia coronavirus COVID-19 memory T cell olfactory epithelium pandemic paxlovia SARS-CoV-2 viral viruses Source Type: blogs

TWiV 828: COVID-19 clinical update #88 with Dr. Daniel Griffin
In COVID-19 clinical update #88, Dr. Griffin covers vaccine protection among US veterans, absence of long COVID in vaccinated who are infected, single dose of REGEN-COV monoclonal antibody cocktail provides long term protection, and Pfizer protease inhibitor Paxlovid is 89% effective in preventing hospitalization or death. Show notes at microbe.tv/twiv (Source: virology blog)
Source: virology blog - November 13, 2021 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs

Red blood cells are immune sentinels
Did you know that the innate immune DNA sensor TLR9 is on the membrane of red blood cells? I didn’t know that. To learn about why it’s there, listen to Immune episode #50. In that episode we review evidence that toll-like receptor 9 on the surface of red blood cells binds DNA, leading to uptake […] (Source: virology blog)
Source: virology blog - November 12, 2021 Category: Virology Authors: Vincent Racaniello Tags: Immune Information anemia DNA immunology inflammation innate immune sensor red blood cell sepsis TLR9 Source Type: blogs

Pills for COVID-19
Multiple vaccines have been developed that have made substantial contributions to controlling the COVID-19 pandemic, but where are the antivirals? Only repurposed drugs have been used and not with much success. That situation seems about to change with the authorization of drugs that target the RNA polymerase (Molnupiravir) and a viral protease (Paxlovid). Molnupiravir is […] (Source: virology blog)
Source: virology blog - November 12, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antiviral coronavirus COVID-19 Molnupiravir Paxlovid protease inhibitor SARS-CoV-2 viruses Source Type: blogs

Trial By Error: Authors Alicia Butcher Ehrhardt and Nasim Marie Jafry Discuss Their Novels
By David Tuller, DrPH It is hard enough to write when you’re feeling healthy. So I’m in awe of people who manage to write despite suffering from a debilitating chronic illness—especially one that messes around with cognitive functioning. That number includes some ME patients who have written novels. (I don’t write fiction; I have a […] (Source: virology blog)
Source: virology blog - November 10, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: King ’ s College London Is Still Hyping “ Bespoke ” CBT for CFS as “ Recommended ” in UK
By David Tuller, DrPH A week ago, Britain’s National Institute for Health and Care Excellence published its new, evidence-based guideline for ME/CFS, which recommended against graded exercise therapy and cognitive behavior therapy offered as curative rather than as supportive care. Not surprisingly, this event creates some public relations problems for members of the CBT/GET ideological […] (Source: virology blog)
Source: virology blog - November 5, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized King's College London NICE Trudie Chalder Source Type: blogs

Spikevax Induces Durable Protection from the Delta Variant in Rhesus Macaques
Rhesus macaques that are vaccinated against SARS-CoV-2 are protected from severe disease and probably transmit very little virus when infected with SARS-CoV-2 one year later. (Source: virology blog)
Source: virology blog - November 4, 2021 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey ACE2 antibody antibody affinity antibody avidity delta variant human challenge model IgA IgG immunity memory B cell Moderna mRNA-1273 mucosal immunity neutralizing antibody rhesus macaque SARS-C Source Type: blogs

Trial By Error: Losers in NICE Guideline Fight Remain Defiant Despite Public Repudiation of Their Claims
By David Tuller, DrPH It is not surprising that esteemed experts whose research has been publicly exposed as a bunch of crap would push back quickly, and that promoters of the debunked work would rally round in defense. That’s what we’ve seen in the wake of Friday’s publication of a new ME/CFS guideline from the […] (Source: virology blog)
Source: virology blog - October 31, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: NICE Liberates New ME/CFS Guideline After Two-Month Hijacking Nightmare
By David Tuller, DrPH After much drama, the National Institute for Health and Care Excellence (NICE) has finally liberated its hijacked ME/CFS clinical guideline. As many know, in August the agency abruptly called off the planned publication of this new document, which was developed over four years. This decision occurred in the wake of fierce […] (Source: virology blog)
Source: virology blog - October 29, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized NICE Source Type: blogs

Wuhan spiny eel influenza virus
Influenza B viruses, unlike influenza A viruses, do not cause pandemics. There are many non-human animal reservoirs of influenza A viruses which provide gene segments that go towards making reassortant viruses that can infect humans. Influenza B viruses do not appear to have an animal reservoir other than humans – they have been isolated from […] (Source: virology blog)
Source: virology blog - October 29, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology HA influenza B virus influenza virus pandemic viral viruses Wuhan spiny eel virus Source Type: blogs

Trial By Error: PACE Authors Now Blame “ Misunderstandings ” for GET/CBT Criticisms
By David Tuller, DrPH It is hard to know what to make of the news that a peer-reviewed journal has actually accepted a PACE-reunion paper from the three lead investigators—Professors Michael Sharpe, Trudie Chalder, and Peter White. Even more so for a paper titled–without irony, it seems–“Evidence based care for people with chronic fatigue syndrome […] (Source: virology blog)
Source: virology blog - October 23, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized chalder Michael Sharpe NICE PACE Peter White Source Type: blogs

Trial By Error: NICE Announces Upcoming Release of ME/CFS Guideline After Prolonged Hostage Drama
By David Tuller, DrPH Two days following a high-profile meeting with opponents and supporters of its new-but-still-unpublished ME/CFS guideline, the UK’s National Institute for Health and Care Excellence announced on Wednesday that it plans to release the document next week. The decision comes after a powerful cabal of medical practitioners held the process hostage for […] (Source: virology blog)
Source: virology blog - October 20, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Trial By Error: Advocates Issue Hopeful Comments After NICE Pow-Wow on ME/CFS Guideline
By David Tuller, DrPH Two months ago, the UK’s National Institute for Health and Care Excellence (NICE) abruptly delayed publication of its new ME/CFS clinical guideline under fierce objections from the GET/CBT ideological brigades and their minions. Today (Monday, October 18th), the agency hosted a meeting to allow these powerful dissenters from some of the […] (Source: virology blog)
Source: virology blog - October 19, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Charles Shepherd Jonathan Edwards NICE Source Type: blogs

Trial By Error: North Bristol NHS Trust ’ s Biased Survey of Patients Attending “ CFS/ME Specialist Services ”
By David Tuller, DrPH *October is crowdfunding month at Berkeley. I conduct this project as a senior fellow in public health and journalism at the university’s Center for Global Public Health. If you would like to support the project with a donation to Berkeley (tax-deductible for US taxpayers), here’s the place: https://crowdfund.berkeley.edu/project/27513 Two years ago, […] (Source: virology blog)
Source: virology blog - October 15, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

Molnupiravir, a SARS-CoV-2 antiviral drug, is mutagenic in cells
Molnupiravir might be the first highly effective antiviral drug given emergency use authorization for treatment of COVID-19. Should we be concerned about the results of a recent study which show that the drug is mutagenic in cells? Molnupiravir is an orally available pro-drug of the nucleoside analog N4-hydroxycytidine (NHC). The latter is a nucleoside analogue […] (Source: virology blog)
Source: virology blog - October 15, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology antiviral drug COVID-19 Molnupiravir mutagenesis pandemic SARS-CoV-2 virus viruses Source Type: blogs

Trial By Error: Professor Lubet ’ s Take on The New Yorker ’ s Long Covid Article
By David Tuller, DrPH I wrote a post last month about the recent wave of Long Covid coverage—some of it excellent (The Atlantic) and some way over the edge in its assertions of psychogenic causation of symptoms (The American Spectator, Spiked). Then there was the seemingly sympathetic New Yorker article by a physician, with its […] (Source: virology blog)
Source: virology blog - October 8, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Long Covid New Yorker psychogenic Source Type: blogs

Trial By Error: UC Berkeley ’ s October Crowdfunding Campaign
By David Tuller, DrPH When I launched the Trial By Error project in 2015 with a 15,000-word investigation of the piece of crap known more formally as the PACE trial, I had no idea I was launching anything. I figured it was a one-off. After all, could such a disaster of a study really survive […] (Source: virology blog)
Source: virology blog - October 8, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

An Appreciation for Viruses
Most people associate viruses with illness and suffering, however, considering that the vast majority of viruses cause no illness and are actually beneficial to humans and the planet as a whole, this sentiment is largely misplaced. (Source: virology blog)
Source: virology blog - October 7, 2021 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey adenovirus-vectored vaccine bacteriophage crispr gene editing gene therapy microbe oncolytic vector oncolytic virotherapy phage therapy phytoplankton retrovirus vaccines viral oncotherapy virus batt Source Type: blogs

Trial By Error: BBC ’ s Problematic Coverage of New Long COVID Study
By David Tuller, DrPH Since the start of the coronavirus pandemic, suggesting an equivalence between COVID-19 and influenza has been a consistent approach among those seeking to downplay the current situation. So it’s not surprising to see something similar happen with comparisons between Long COVID and the delayed recovery some people experience after an acute […] (Source: virology blog)
Source: virology blog - October 4, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized BBC Long Covid PLoS Medicine Source Type: blogs

Gain of function to build therapeutically useful viral vectors
Another excellent example of gain of function research is modification of a viral vector to make it more useful for human gene therapy. Adenovirus associated virus (AAV) is the most commonly used vector for a variety of gene therapy applications, including gene replacement and gene editing. These small viruses, which comprise a single-stranded DNA genome […] (Source: virology blog)
Source: virology blog - October 1, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology aav adenovirus associated virus gene therapy integral muscle diseases RDG viral viruses Source Type: blogs

Trial By Error: Good Long Covid Coverage from Atlantic; Skeptical Coverage from New Yorker and Others
By David Tuller, DrPH On September 1st, The Atlantic published another excellent piece by Ed Yong—“Long-haulers are fighting for their future.” In exploring how this population has confronted widespread misunderstanding in the medical community, the article highlighted the links between the experiences of Long Covid and ME/CFS patients by focusing on the crucial symptom of […] (Source: virology blog)
Source: virology blog - September 25, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs

SARS-CoV-2 related viruses from bats in Laos
Various SARS-CoV-2 like viruses have been isolated from bats in China, Thailand, and Japan, but none have a spike protein that can bind ACE2 and allow entry into human cells. Sampling of bats in Laos has now revealed the presence of such viruses. The genome of a virus called RaTG13, from Rhinolophus affinis bats in […] (Source: virology blog)
Source: virology blog - September 24, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information ACE2 coronavirus COVID-19 Laos pandemic RaTG13 receptor binding domain SARS-CoV-2 spillover viral viruses zoonotic event Source Type: blogs

Trial By Error: Advocates Propose Fixes to Dysfunctional US Coding System for ME, CFS and ME/CFS
By David Tuller, DrPH I have been focused lately on the continuing saga of the hijacked-and-still-unpublished ME/CFS clinical guidelines (HSUME/CFSCG) from Britain’s National Institute for Health and Care Excellence (NICE). The fate of the HSUME/CFSCG will apparently be addressed at an October so-called “roundtable” meeting of NICE and representatives from relevant interest groups. (I’m not […] (Source: virology blog)
Source: virology blog - September 20, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized coding Dimmock ICD Source Type: blogs

A zero time point is essential
The recent release of grant materials from EcoHealth Alliance pertaining to their research with the Wuhan Institute of Virology has been used to demonstrate that gain of function research was funded by the NIH. This conclusion is correct, although not all the experiments done would fall into this category. One of the figures from the […] (Source: virology blog)
Source: virology blog - September 16, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information coronavirus COVID-19 EcoHealth Alliance gain of function pandemic SARS-CoV-2 transgenic mice viral viruses Wuhan Institute of Virology Source Type: blogs

Trial By Error: An Updated Letter to the NICE Chief Executive About the Unpublished ME/CFS Guideline
By David Tuller, DrPH I sent the following letter today to Professor Gillian Leng, chief executive of the National Institute for Health and Care Excellence (NICE). It was a follow-up to the letter I sent on September 1st about the agency’s decision to delay publication of it new ME/CFS guidelines. The letter has now been […] (Source: virology blog)
Source: virology blog - September 15, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Leng letter NICE Source Type: blogs

Trial By Error: More Science-as-Promotion from the GET Campaigners
By David Tuller, DrPH Professor Trudie Chalder, Professor Peter White and like-minded members of the CBT/GET ideological brigades have appeared desperate in the last year to promote their favored interventions, publishing one shoddy paper after another. This stream of sewage has seemed intended  to influence the new ME/CFS clinical guidelines that Britain’s National Institute for […] (Source: virology blog)
Source: virology blog - September 14, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized chalder GET NICE Source Type: blogs

Gain of function research explained
The term ‘gain of function’ is perhaps one of the most misunderstood in the scientific lexicon. I would like to explain what the phrase means from the perspective of a scientist who has done gain of function research for the past 40 years. Gain of function (GoF) research gives an organism a new property or […] (Source: virology blog)
Source: virology blog - September 10, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology avian influenza virus coronavirus COVID-19 ferret gain of function research GOF pandemic viral viruses Source Type: blogs

Trial By Error: Jennie Spotila ’ s Annual Fact-Check of NIH Spending on ME/CFS Research
By David Tuller, DrPH There is a lot going on in the ME and ME/CFS world that I don’t get around to. That’s why I’m always grateful that Jennie Spotila always deconstructs the numbers on the annual spending claims from the National Institutes of Health. Last month, on her blog Occupy M.E., Spotila submitted the […] (Source: virology blog)
Source: virology blog - September 8, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized NIH spotila Source Type: blogs

Innately Immune
New data suggest that children are less susceptible to severe COVID-19 because they have a stronger innate immune response than adults. (Source: virology blog)
Source: virology blog - September 2, 2021 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey ACE2 children COVID-19 cytokine innate immune response innate immunity innate sensor interferon gamma MDA5 memory T cells neutrophil RIG-I SARS-CoV-2 Source Type: blogs

Trial By Error: While NICE Waffles, US Specialists Publish New Clinical Guidelines for ME/CFS
By David Tuller, DrPH Two weeks ago, NICE abruptly announced that it was putting the brakes on publication of its new ME/CFS guidelines—a move precipitated by fierce opposition from key members of the GET/CBT ideological brigades in the British medical establishment. Then last week, Mayo Clinic Proceedings, a well-known journal, published a different set of […] (Source: virology blog)
Source: virology blog - September 1, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized Mayo NICE Source Type: blogs

Trial By Error: A Letter Urging NICE to Publish ME/CFS Guideline Without Delay
By David Tuller, DrPH This morning, I sent the following letter to Professor Gillian Leng, the chief executive of the National Institute for Health and Care Excellence. ********** Professor Gillian Leng CBEChief ExecutiveNational Institute for Health and Care Excellence Dear Professor Leng, Please find below a letter urging NICE to publish the new ME/CFS guideline, […] (Source: virology blog)
Source: virology blog - September 1, 2021 Category: Virology Authors: David Tuller Tags: David Tuller ME/CFS Source Type: blogs

More coronaviruses in rodents
This week President Biden received the report he commissioned on the origin of SARS-CoV-2. As I predicted three months ago, nothing was learned, because to find the origin of the virus it is necessary to conduct extensive wildlife surveys. Consequently this week I would rather write about a new study that identified coronaviruses in rodents. […] (Source: virology blog)
Source: virology blog - August 27, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology bats coronavirus COVID-19 furin cleavage site pandemic rodents SARS-CoV-2 spillover viral viruses zoonotic pathogen Source Type: blogs

Trial By Error: NICE Squares Off Against Royal College Bullies Over New ME/CFS Guidelines
By David Tuller, DrPH For many years, campaigners for psycho-behavioral interventions for ME/CFS have accused patients who objected to the research as being anti-scientific zealots. It was always a ridiculous charge, but developments this week have made it clear, if there was any doubt, that these entitled bullies are the ones immune to the actual […] (Source: virology blog)
Source: virology blog - August 20, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized NICE Source Type: blogs

Are COVID-19 vaccine boosters needed?
The US Centers for Disease Control have concluded that a third dose of COVID-19 vaccine will be needed for protection against disease, but the science says otherwise. A review of the immune responses to infection will help explain why vaccine boosters are not needed. The graph below shows the relative concentrations of antibody and T […] (Source: virology blog)
Source: virology blog - August 20, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology coronavirus COVID-19 pandemic SARS-CoV-2 vaccine vaccine booster viral viruses Source Type: blogs

Trial By Error: NICE Squares Off Against Royal College Bullies Over New ME/CFS Guidelines
By David Tuller, DrPH For many years, campaigners for psycho-behavioral interventions for ME/CFS have accused patients who objected to the research as being anti-scientific zealots. It was always a ridiculous charge, but developments this week have made it clear, if there was any doubt, that these entitled bullies are the ones immune to the actual […] (Source: virology blog)
Source: virology blog - August 19, 2021 Category: Virology Authors: David Tuller Tags: David Tuller ME/CFS NICE Source Type: blogs

Estimate of infectiousness during COVID-19
Understanding the transmission of SARS-CoV-2 is complicated by the large numbers of presymptomatic, asymptomatic, and mildly symptomatic (PAMS) patients. The reproductive number, R0, is a measure of population-level dynamics, but it cannot provide information on infectiousness of different groups such as PAMS subjects; when peak infectiousness occurs; and the effect of intrinsic properties of the […] (Source: virology blog)
Source: virology blog - August 13, 2021 Category: Virology Authors: Vincent Racaniello Tags: Basic virology alpha variant coronavirus COVID-19 infectiousness pandemic SARS-CoV-2 transmission variant of concern viral viral RNA load viruses Source Type: blogs

Trial By Error: The Times Fact-Checks BMJ on NICE Committee; My Letter to BMJ ’ s Fiona Godlee
By David Tuller, DrPH It is not often that a major news organization fact-checks BMJ, a leading medical publisher, in real time. But that’s what happened last week when The Times pushed back against biased BMJ reporting about the committee charged by the UK’s National Institute for Health and Care Excellence (NICE) with developing a […] (Source: virology blog)
Source: virology blog - August 10, 2021 Category: Virology Authors: David Tuller Tags: Uncategorized BMJ Godlee NICE O'Neill The Times Source Type: blogs