TWiV 880: COVID-19 clinical update #107 with Dr. Daniel Griffin
In COVID-19 clinical update #107, Daniel Griffin discusses Moderna vaccine results in children, hospitalization by ethnicity, BA.2 severity in children, placentitis and thrombohematoma during pregnancy, predictive value of symptoms for diagnosis, Evusheld activity against BA.1 and BA.2, Remdesivir resistance, Ivermectin with and without strongyloidiasis, inhaled ciclesonide, home telemonitoring, pulse oximetry for remote monitoring, effectiveness of anti-platelet therapy, and deaths in Zambia. (Source: virology blog)
Source: virology blog - March 26, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
TWiV 879: Indolent, resistant, and losing our TMPRSS
TWiV reviews the emergence of remdesivir-resistant SARS-CoV-2 during treatment of a persistently infected immunocompromised patient, and how altered TMPRSS2 utilization by the Omicron variant influences infectivity and fusion. (Source: virology blog)
Source: virology blog - March 24, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology coronavirus COVID-19 delta furin cleavage site fusion Omicron pandemic SARS-CoV-2 Tmprss2 viral viruses Source Type: blogs
Q & A with A & V Livestream 3/23/22
Virologists Amy Rosenfeld and Vincent Racaniello answer your COVID-19 questions (or any virus questions) on this livestream of 3/23/22 at 8:30 PM eastern US. (Source: virology blog)
Source: virology blog - March 24, 2022 Category: Virology Authors: Vincent Racaniello Tags: Q&A with A&V antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern virology viruses Source Type: blogs
Fight Aging! Newsletter, March 21st 2022
This study was the first to examine how these networks interact with physical activity and fitness to impact how the brain functions.
"This paper is exciting because it gives us some evidence that when people whose brain networks aren't functioning optimally engage in physical activity, we see improvement in their executive function and their independence. Maybe just take the stairs on the way to work. Stand up and walk around a little bit more. That's where you get the most bang for your buck, not crazy, high-intensity exercise."
Variations in Biological Age Across Organs in Younger Individuals
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Source: Fight Aging! - March 20, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
TWiV 877: COVID-19 clinical update #106 with Dr. Daniel Griffin
In COVID-19 clinical update #106, Daniel Griffin covers failure of ivermectin to improve hospitalization, increased hospitalization of children with Omicron, seroconversion of children versus adults, effectiveness of Pfizer mRNA vaccine in children, high vaccine effectiveness in Finland against Omicron, distinct long COVID clinical phenotypes, and estimating worldwide excess mortality. (Source: virology blog)
Source: virology blog - March 19, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
The (sort of, partial) Father mRNA Vaccines Who Now Spreads Vaccine Misinformation (Part 2)
By DAVID WARMFLASH, MD
This is part 2 of David Warmlash’s takedown of Robert W. Malone’s appearance (transcript) on the Rogan podcast. Part 1 is here
Menstruation and Fertility
Much more than the line about reproductive damage in the Wisconsin News clip that we used to open the story, Malone used the Rogan interview to dive more deeply into the topic, starting with:
…there’s a huge number of dysmenorrhea and menometrorrhagia…
By that, he meant excessive menstrual cramping and very heavy, often irregular, bleeding, which he followed up with:
…they DENY it…
Judging by other parts ...
Source: The Health Care Blog - March 18, 2022 Category: Consumer Health News Authors: matthew holt Tags: COVID-19 Health Policy antivaxxer COVID-19 vaccine David Warmflash Joe Rogan Robert Malone Source Type: blogs
The (sort of, partial) Father mRNA Vaccines Who Now Spreads Vaccine Misinformation (Part 1)
By DAVID WARMFLASH, MD
Robert W. Malone, MD MS, is a physician-scientist who will live in infamy, thanks to the Joe Rogan Experience Podcast boosting his visibility this past December regarding his criticism of COVID-19 vaccines, particularly the mRNA vaccines (Moderna and Pfizer-BioNTech). Subsequently, Malone was banned from Twitter, which further boosted his celebrity status. Describing himself as the inventor of mRNA vaccine technology, he has been reaching a growing number of people with a narrative that makes COVID-19 vaccination sound scary. We cannot embed clips from the Rogan interview, which lasted about three...
Source: The Health Care Blog - March 17, 2022 Category: Consumer Health News Authors: matthew holt Tags: COVID-19 Health Policy antivaxxer COVID-19 vaccine David Warmflash Joe Rogan Robert Malone Source Type: blogs
TWiV 876: Spillover market with Michael Worobey
Michael Worobey joins TWiV to explain evidence that SARS-CoV-2 emerged via the wildlife trade and that the Huanan market was the unambiguous epicenter of the COVID-19 pandemic. (Source: virology blog)
Source: virology blog - March 17, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology COVID-19 Huanan Market live animal market pandemic SARS-CoV-2 spillover viral virus viruses Wuhan Source Type: blogs
Reviewing the Mechanisms that Allow Senescent Cells to Resist Apoptosis
A large portion of research into senescent cells in the context of degenerative aging is focused on how these cells fail to destroy themselves. Senescent cells are primed to enter the programmed cell death process of apoptosis, but various mechanisms hold this off. Sabotaging some of those mechanisms is an effective way to clear a sizable fraction of senescent cells in many old tissues, as demonstrated by the initial small molecule senolytic treatments, such as the dasatinib and quercetin combination.
As the authors of today's open access paper note, the fact that these apoptosis-inducing senolytics are only partial...
Source: Fight Aging! - March 16, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Modified Red Blood Cells for COVID-19 Vaccination
Researchers at McMaster University in Ontario, Canada created engineered red blood cells to act as a new COVID-19 vaccine technology. The cell membranes have been studded with the SARS-CoV-2 spike protein, and in experiments the researchers have conducted in mice the cells can trigger an immune response with minimal side-effects. The team reports that the technique is relatively quick and easy to perform, and it could be useful in developing vaccines against a variety of viruses and future COVID-19 variants.
It appears that humans work most effectively under pressure and times of crisis can be a powerful catalyst for in...
Source: Medgadget - March 15, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology Materials Medicine Nanomedicine Source Type: blogs
TWiV 875: Animal house
TWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait. (Source: virology blog)
Source: virology blog - March 13, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology ACE2 coronavirus COVID-19 SARS-CoV-2 spike spillover viral viruses zoonosis Source Type: blogs
TWiV 874: COVID-19 clinical update #105 with Dr. Daniel Griffin
In COVID-19 clinical update #105, Daniel Griffin discusses changes in brain structure after infection, dementia in patients with pneumonia, Paxlovid in children, mask effectiveness in schools, host factors and severe disease, post-acute symptoms, and the mission of CEPI. Click arrow to playDownload TWiV 874 (49 MB .mp3, 41 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Show notes […] (Source: virology blog)
Source: virology blog - March 12, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody Omicron pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
TWiV 872: COVID-19 clinical update #104 with Dr. Daniel Griffin
In COVID-19 clinical update #104, Daniel Griffin reviews effectiveness of mRNA vaccines among children, number of children affected by disease, accuracy of rapid antigen tests, CDC guidance for prevention strategies, monoclonal antibody effectiveness, predicting progression to severe respiratory failure from pneumonia, risk of long COVID after two vaccine doses, and peripheral neuropathy in long COVID. (Source: virology blog)
Source: virology blog - March 5, 2022 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antiviral coronavirus COVID-19 delta inflammation Long Covid monoclonal antibody pandemic SARS-CoV-2 vaccine vaccine booster variant of concern viruses Source Type: blogs
An Intranasal SARS-CoV-2 Vaccine Candidate
Intranasal administration with a single dose of a chimpanzee adenovirus-vectored SARS-CoV-2 vaccine induces potent immune responses. (Source: virology blog)
Source: virology blog - March 3, 2022 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey antibody b cells cytotoxic T cells IgA IgG intramuscular intranasal vaccine macrophages MHCII nucleocapsid RdRp SARS-CoV-2 spike protein trained innate immunity Source Type: blogs
Microfluidic Device for Quick and Accurate SARS-CoV-2 Testing
Researchers at the Institute of Photonic Sciences in Barcelona, Spain, have created a microfluidic chip that can detect the SARS-CoV-2 virus in less than 30 minutes, and with a similar level of accuracy as the current gold-standard test, PCR. The technology combines the speed of antigen tests with the accuracy of PCR and may be useful for point-of-care testing. The technique involves combining a few drops of saliva with fluorescent antibodies against the virus. Then, the saliva sample is passed through a microfluidic channel, where a laser illuminates bound fluorescent antibodies and an optical detector rapidly assesses if...
Source: Medgadget - March 1, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Public Health Source Type: blogs
