Toxicological assessment of photoactivated tetra-cationic porphyrin molecules under white light exposure in a Caenorhabditis elegans model
In this study, we used Caenorhabditis elegans, a small free-living nematode, as a model for assessing toxic effects and predicting toxicity in preclinical research. We evaluated the toxic effects of porphyrins (neutral and tetra-cationic) on nematodes under dark/light conditions. Our findings demonstrate that tetra-methylated porphyrins (3TMeP and 4TMeP) at a concentration of 3.3µg/mL (1.36 and 0.93µM) exhibit high toxicity (as evidenced by reduced survival, development, and locomotion) under dark conditions. Moreover, photoactivated tetra-methylated porphyrins induce higher ROS levels compared to neutral (3TPyP and 4TPy...
Source: Toxicology - April 4, 2024 Category: Toxicology Authors: Gabriela Vit ória de Oliveira Marcell Valandro Soares Larissa Marafiga Cordeiro Aline Franzen da Silva Luiza Venturini Larissa Ilha Fabiane Bicca Obetine Baptista T ássia Limana da Silveira F élix Alexandre Antunes Soares Bernardo Almeida Iglesias Source Type: research
Integrated In-Silico and In Vitro analysis to Decipher the contribution of bisphenol-A in cervical cancer
Toxicology. 2024 Mar 29;504:153791. doi: 10.1016/j.tox.2024.153791. Online ahead of print.ABSTRACTBisphenol A (BPA) is a synthetic chemical widely used as a monomer for producing polycarbonate plastics. The present investigation employed an in-silico approach to identify BPA-responsive genes and comprehend the biological functions affected using in vitro studies. A Comparative Toxicogenomics Database search identified 29 BPA-responsive genes in cervical cancer (CC). Twenty-nine genes were screened using published datasets, and thirteen of those showed differential expression between normal and CC samples. Protein-Protein I...
Source: Toxicology - March 31, 2024 Category: Toxicology Authors: Nadeem Ghani Khan Divya Adiga Padmalatha Satwadi Rai Shama Prasada Kabekkodu Source Type: research
Integrated In-Silico and In Vitro analysis to Decipher the contribution of bisphenol-A in cervical cancer
Toxicology. 2024 Mar 29;504:153791. doi: 10.1016/j.tox.2024.153791. Online ahead of print.ABSTRACTBisphenol A (BPA) is a synthetic chemical widely used as a monomer for producing polycarbonate plastics. The present investigation employed an in-silico approach to identify BPA-responsive genes and comprehend the biological functions affected using in vitro studies. A Comparative Toxicogenomics Database search identified 29 BPA-responsive genes in cervical cancer (CC). Twenty-nine genes were screened using published datasets, and thirteen of those showed differential expression between normal and CC samples. Protein-Protein I...
Source: Toxicology - March 31, 2024 Category: Toxicology Authors: Nadeem Ghani Khan Divya Adiga Padmalatha Satwadi Rai Shama Prasada Kabekkodu Source Type: research
Integrated In-Silico and In Vitro Analysis to Decipher the Contribution of Bisphenol-A in Cervical Cancer
Toxicology. 2024 Mar 29:153791. doi: 10.1016/j.tox.2024.153791. Online ahead of print.ABSTRACTBisphenol A (BPA) is a synthetic chemical widely used as a monomer for producing polycarbonate plastics. The present investigation employed an in-silico approach to identify BPA-responsive genes and comprehend the biological functions affected using in vitro studies. A Comparative Toxicogenomics Database search identified 29 BPA-responsive genes in cervical cancer (CC). Twenty-nine genes were screened using published datasets, and thirteen of those showed differential expression between normal and CC samples. Protein-Protein Inter...
Source: Toxicology - March 31, 2024 Category: Toxicology Authors: Nadeem Khan Ghani Divya Adiga Padmalatha Satwadi Rai Shama Prasada Kabekkodu Source Type: research
Integrated In-Silico and In Vitro Analysis to Decipher the Contribution of Bisphenol-A in Cervical Cancer
Toxicology. 2024 Mar 29:153791. doi: 10.1016/j.tox.2024.153791. Online ahead of print.ABSTRACTBisphenol A (BPA) is a synthetic chemical widely used as a monomer for producing polycarbonate plastics. The present investigation employed an in-silico approach to identify BPA-responsive genes and comprehend the biological functions affected using in vitro studies. A Comparative Toxicogenomics Database search identified 29 BPA-responsive genes in cervical cancer (CC). Twenty-nine genes were screened using published datasets, and thirteen of those showed differential expression between normal and CC samples. Protein-Protein Inter...
Source: Toxicology - March 31, 2024 Category: Toxicology Authors: Nadeem Khan Ghani Divya Adiga Padmalatha Satwadi Rai Shama Prasada Kabekkodu Source Type: research
Understanding the impact of Nanoplastics on Reproductive Health: Exposure Pathways, Mechanisms, and implications
Toxicology. 2024 Mar 28:153792. doi: 10.1016/j.tox.2024.153792. Online ahead of print.ABSTRACTMicroplastic pollution is a pressing global environmental concern with particular urgency surrounding the issue of nanoplastic particles. Plastic products exhibit a remarkable persistence in natural ecosystems, resisting easy degradation. Nanoplastics, characterized by their diminutive size, possess distinct properties when compared to their larger counterparts, which could potentially render them more ecologically detrimental. Microplastics themselves serve as carriers for toxic and hazardous substances, such as plastic additives...
Source: Toxicology - March 30, 2024 Category: Toxicology Authors: Jingfan Ye Yun Ren Yanhui Dong Dongwei Fan Source Type: research
Understanding the impact of Nanoplastics on Reproductive Health: Exposure Pathways, Mechanisms, and implications
Toxicology. 2024 Mar 28:153792. doi: 10.1016/j.tox.2024.153792. Online ahead of print.ABSTRACTMicroplastic pollution is a pressing global environmental concern with particular urgency surrounding the issue of nanoplastic particles. Plastic products exhibit a remarkable persistence in natural ecosystems, resisting easy degradation. Nanoplastics, characterized by their diminutive size, possess distinct properties when compared to their larger counterparts, which could potentially render them more ecologically detrimental. Microplastics themselves serve as carriers for toxic and hazardous substances, such as plastic additives...
Source: Toxicology - March 30, 2024 Category: Toxicology Authors: Jingfan Ye Yun Ren Yanhui Dong Dongwei Fan Source Type: research
Germ-free Status but Not Subacute Polychlorinated Biphenyl (PCB) Exposure Altered Hepatic Phosphatidylcholine and Ether-Phosphatidylcholine Levels in Mice
Toxicology. 2024 Mar 27:153790. doi: 10.1016/j.tox.2024.153790. Online ahead of print.ABSTRACTPolychlorinated biphenyls (PCBs) are persistent organic pollutants that pose a current ecosystem and human health concern. PCB exposure impacts the gut microbiome in animal models, suggesting a mechanistic link between PCB exposure and adverse health outcomes. The presence and absence of the microbiome and exposure to PCBs independently affect the lipid composition in the liver, which in turn affects the PCB disposition in target tissues, such as the liver. Here, we investigated microbiome × subacute PCB effects on the hepatic li...
Source: Toxicology - March 29, 2024 Category: Toxicology Authors: Xueshu Li Hui Wang Hui Wang Amanda J Bullert Julia Yue Cui Kai Wang Hans-Joachim Lehmler Source Type: research
Protective effect of dental pulp stem cells' conditioned medium against cisplatin-induced testicular damage in rats
This study investigated the effectiveness of dental pulp mesenchymal stem cells conditioned medium (DPSC-CM) on cisplatin-induced testicular toxicity. In this study, 36 eight-week-old male Wistar rats were randomly divided into three groups equally (n = 12). Group 1 control "CTR", which received normal saline (0.5ml) intraperitoneally (i.p), group 2 "Cis" which received an intraperitoneal dose of cisplatin (7mg/kg), and group 3 "Cis+CM" which received an i.p injection of DPSC-CM (0.5mg/kg) after cisplatin injection. Biochemical, histomorphometric, and histopathological studies were performed on the testis. Our results exhi...
Source: Toxicology - March 25, 2024 Category: Toxicology Authors: Afsaneh Hokmabadi Esmaeil Ranjbar Fatemeh Alipour Alireza Ebrahimzadeh-Bideskan Jalil Tavakol Afshari Mohammad Morteza Rezaei Reyhaneh Shafieian Source Type: research
Protective effect of dental pulp stem cells' conditioned medium against cisplatin-induced testicular damage in rats
This study investigated the effectiveness of dental pulp mesenchymal stem cells conditioned medium (DPSC-CM) on cisplatin-induced testicular toxicity. In this study, 36 eight-week-old male Wistar rats were randomly divided into three groups equally (n = 12). Group 1 control "CTR", which received normal saline (0.5ml) intraperitoneally (i.p), group 2 "Cis" which received an intraperitoneal dose of cisplatin (7mg/kg), and group 3 "Cis+CM" which received an i.p injection of DPSC-CM (0.5mg/kg) after cisplatin injection. Biochemical, histomorphometric, and histopathological studies were performed on the testis. Our results exhi...
Source: Toxicology - March 25, 2024 Category: Toxicology Authors: Afsaneh Hokmabadi Esmaeil Ranjbar Fatemeh Alipour Alireza Ebrahimzadeh-Bideskan Jalil Tavakol Afshari Mohammad Morteza Rezaei Reyhaneh Shafieian Source Type: research
Protective effect of dental pulp stem cells' conditioned medium against cisplatin-induced testicular damage in rats
This study investigated the effectiveness of dental pulp mesenchymal stem cells conditioned medium (DPSC-CM) on cisplatin-induced testicular toxicity. In this study, 36 eight-week-old male Wistar rats were randomly divided into three groups equally (n = 12). Group 1 control "CTR", which received normal saline (0.5ml) intraperitoneally (i.p), group 2 "Cis" which received an intraperitoneal dose of cisplatin (7mg/kg), and group 3 "Cis+CM" which received an i.p injection of DPSC-CM (0.5mg/kg) after cisplatin injection. Biochemical, histomorphometric, and histopathological studies were performed on the testis. Our results exhi...
Source: Toxicology - March 25, 2024 Category: Toxicology Authors: Afsaneh Hokmabadi Esmaeil Ranjbar Fatemeh Alipour Alireza Ebrahimzadeh-Bideskan Jalil Tavakol Afshari Mohammad Morteza Rezaei Reyhaneh Shafieian Source Type: research
Protective effect of dental pulp stem cells' conditioned medium against cisplatin-induced testicular damage in rats
This study investigated the effectiveness of dental pulp mesenchymal stem cells conditioned medium (DPSC-CM) on cisplatin-induced testicular toxicity. In this study, 36 eight-week-old male Wistar rats were randomly divided into three groups equally (n = 12). Group 1 control "CTR", which received normal saline (0.5ml) intraperitoneally (i.p), group 2 "Cis" which received an intraperitoneal dose of cisplatin (7mg/kg), and group 3 "Cis+CM" which received an i.p injection of DPSC-CM (0.5mg/kg) after cisplatin injection. Biochemical, histomorphometric, and histopathological studies were performed on the testis. Our results exhi...
Source: Toxicology - March 25, 2024 Category: Toxicology Authors: Afsaneh Hokmabadi Esmaeil Ranjbar Fatemeh Alipour Alireza Ebrahimzadeh-Bideskan Jalil Tavakol Afshari Mohammad Morteza Rezaei Reyhaneh Shafieian Source Type: research
Reproductive toxicity of cadmium stress in male animals
Toxicology. 2024 Mar 22:153787. doi: 10.1016/j.tox.2024.153787. Online ahead of print.ABSTRACTCadmium (Cd) is a common heavy metal pollutant in the environment, and the widespread use of products containing Cd compounds in industry has led to excessive levels in the environment, which enter the animal body through the food chain, thus seriously affecting the reproductive development of animals. Related studies have reported that Cd severely affects spermatogonia development and spermatogenesis in animals. In contrast, the reproductive toxicity of Cd in males and its mechanism of action have not been clarified. Therefore, t...
Source: Toxicology - March 24, 2024 Category: Toxicology Authors: Zikun Zhang Qi Wang Xiaoge Gao Xu Tang Huan Xu Wenqiang Wang Xin Lei Source Type: research
Effect of modified citrus pectin on galectin-3 inhibition in cisplatin-induced cardiac and renal toxicity
In conclusion, MCP therapy in the acute model of cisplatin-induced toxicity increases oxidative stress in cardiac and renal tissues. Further investigations are needed to determine the beneficial and harmful roles of Gal-3 in the cardiorenal system since it can act differently in acute and chronic diseases/conditions.PMID:38522819 | DOI:10.1016/j.tox.2024.153786 (Source: Toxicology)
Source: Toxicology - March 24, 2024 Category: Toxicology Authors: Diego D Santos Nycole M Belote Gisela R S Sasso Rebeca D Correia-Silva Paulo C Franco Artur Francisco da Silva Neto Fernanda T Borges Lila M Oyama Cristiane D Gil Source Type: research
Chlorpyrifos impairs sperm parameters and number of Sertoli and Leydig cells in rats after exposure during the peripubertal period
Toxicology. 2024 Mar 22:153789. doi: 10.1016/j.tox.2024.153789. Online ahead of print.ABSTRACTChlorpyrifos is an organophosphate insecticide used to control pests in crops. Thus, humans are constantly exposed through ingestion of contaminated food or water, inhalation of contaminated air, and through the skin. The juvenile and peripubertal periods comprise a window of development of the reproductive system, sensitive to toxic agents. Considering the scarcity of data on exposure to the insecticide during these periods, the aim of this study was to evaluate the effects of chlorpyrifos on the testis during the juvenile and pe...
Source: Toxicology - March 24, 2024 Category: Toxicology Authors: Ivana Regina da Costa D ébora Hipólito Quadreli Lucas Marcelo Meira da Silva F ábio Goulart de Andrade Glaura Scantamburlo Alves Fernandes Source Type: research
