Toxicity prediction of nanoparticles using machine learning approaches
This study focuses on developing ML models for nanoparticle toxicity prediction. The training dataset used for building these models includes the physicochemical properties of nanoparticles, exposure conditions, and cellular responses of different cell lines. The impact of each parameter on cell death was assessed using the Gini index. Five classifiers, namely Decision Tree, Random Forest, Support Vector Machine, Naïve Bayes, and Artificial Neural Network, were employed to predict toxicity. The models' performance was compared based on accuracy, sensitivity, specificity, area under the curve, F measure, K-fold validation,...
Source: Toxicology - December 6, 2023 Category: Toxicology Authors: Mahnaz Ahmadi Seyed Mohammad Ayyoubzadeh Fatemeh Ghorbani-Bidkorpeh Source Type: research
ATR induces hepatic lipid metabolism disorder in rats by activating IRE1 α/XBP1 signaling pathway
This study can provide valuable insights as a reference for the prevention and control of hazards associated with agricultural residues.PMID:38056589 | DOI:10.1016/j.tox.2023.153696 (Source: Toxicology)
Source: Toxicology - December 6, 2023 Category: Toxicology Authors: Honghao Qian Yaming Zhao Yiming Wang Haotang Zhao Jianwei Cui Ziyu Wang Hui Ye Xiaoqi Fang Zhili Ge Yuezhu Zhang Lin Ye Source Type: research
Toxicity prediction of nanoparticles using machine learning approaches
This study focuses on developing ML models for nanoparticle toxicity prediction. The training dataset used for building these models includes the physicochemical properties of nanoparticles, exposure conditions, and cellular responses of different cell lines. The impact of each parameter on cell death was assessed using the Gini index. Five classifiers, namely Decision Tree, Random Forest, Support Vector Machine, Naïve Bayes, and Artificial Neural Network, were employed to predict toxicity. The models' performance was compared based on accuracy, sensitivity, specificity, area under the curve, F measure, K-fold validation,...
Source: Toxicology - December 6, 2023 Category: Toxicology Authors: Mahnaz Ahmadi Seyed Mohammad Ayyoubzadeh Fatemeh Ghorbani-Bidkorpeh Source Type: research
Endoplasmic Reticulum Stress and Pro-Inflammatory Responses Induced by Phthalate Metabolites Monoethylhexyl Phthalate and Monobutyl Phthalate in 1.1B4 Pancreatic Beta Cells
In conclusion, this study provides comprehensive insights into the diverse impacts of MEHP and MBP on 1.1B4 pancreatic beta cells, emphasizing their potential role in modulating cell survival, metabolic function, and stress response pathways.PMID:38048874 | DOI:10.1016/j.tox.2023.153695 (Source: Toxicology)
Source: Toxicology - December 4, 2023 Category: Toxicology Authors: Fulya Dal Y öntem Sinem Ayaz Şeyma Bulut Ebru Haciosmano ğlu Aldoğan M üfide Aydoğan Ahbab Source Type: research
Endoplasmic Reticulum Stress and Pro-Inflammatory Responses Induced by Phthalate Metabolites Monoethylhexyl Phthalate and Monobutyl Phthalate in 1.1B4 Pancreatic Beta Cells
In conclusion, this study provides comprehensive insights into the diverse impacts of MEHP and MBP on 1.1B4 pancreatic beta cells, emphasizing their potential role in modulating cell survival, metabolic function, and stress response pathways.PMID:38048874 | DOI:10.1016/j.tox.2023.153695 (Source: Toxicology)
Source: Toxicology - December 4, 2023 Category: Toxicology Authors: Fulya Dal Y öntem Sinem Ayaz Şeyma Bulut Ebru Haciosmano ğlu Aldoğan M üfide Aydoğan Ahbab Source Type: research
Endoplasmic Reticulum Stress and Pro-Inflammatory Responses Induced by Phthalate Metabolites Monoethylhexyl Phthalate and Monobutyl Phthalate in 1.1B4 Pancreatic Beta Cells
In conclusion, this study provides comprehensive insights into the diverse impacts of MEHP and MBP on 1.1B4 pancreatic beta cells, emphasizing their potential role in modulating cell survival, metabolic function, and stress response pathways.PMID:38048874 | DOI:10.1016/j.tox.2023.153695 (Source: Toxicology)
Source: Toxicology - December 4, 2023 Category: Toxicology Authors: Fulya Dal Y öntem Sinem Ayaz Şeyma Bulut Ebru Haciosmano ğlu Aldoğan M üfide Aydoğan Ahbab Source Type: research
Exploring the Effects of Experimental Parameters and Data Modeling Approaches on In Vitro Transcriptomic Point-of-Departure Estimates
Toxicology. 2023 Dec 1:153694. doi: 10.1016/j.tox.2023.153694. Online ahead of print.ABSTRACTMultiple new approach methods (NAMs) are being developed to rapidly screen large numbers of chemicals to aid in hazard evaluation and risk assessments. High-throughput transcriptomics (HTTr) in human cell lines has been proposed as a first-tier screening approach for determining the types of bioactivity a chemical can cause (activation of specific targets vs. generalized cell stress) and for calculating transcriptional points of departure (tPODs) based on changes in gene expression. In the present study, we examine a range of compu...
Source: Toxicology - December 3, 2023 Category: Toxicology Authors: Joshua A Harrill Logan J Everett Derik E Haggard Joseph L Bundy Clinton M Willis Imran Shah Katie Paul Friedman Danilo Basili Alistair Middleton Richard S Judson Source Type: research
Application of QSAR models for acute toxicity of tetrazole compounds administrated orally and intraperitoneally in rat and mouse
In conclusion, the findings of this investigation demonstrate that the proposed QSAR models hold promise in forecasting the acute toxicity of recently developed or synthesized tetrazole compounds, thereby mitigating potential risks to human health and the environment.PMID:38042272 | DOI:10.1016/j.tox.2023.153679 (Source: Toxicology)
Source: Toxicology - December 2, 2023 Category: Toxicology Authors: Zhiyong Liu Junhong Gao Cunzhi Li Lihong Xu Xiaoqiang Lv Hui Deng Yongchao Gao Hong Wang Huan Li Zhigang Wang Source Type: research
Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine
Toxicology. 2023 Nov 30;500:153692. doi: 10.1016/j.tox.2023.153692. Online ahead of print.ABSTRACTAcetaminophen (APAP) overdose causes liver injury and acute liver failure, as well as acute kidney injury, which is not prevented by the clinical antidote N-acetyl-L-cysteine (NAC). The absence of therapeutics targeting APAP-induced nephrotoxicity is due to gaps in understanding the mechanisms of renal injury. APAP metabolism through Cyp2E1 drives cell death in both the liver and kidney. We demonstrate that Cyp2E1 is localized to the proximal tubular cells in mouse and human kidneys. Virtually all the Cyp2E1 in kidney cells is...
Source: Toxicology - December 2, 2023 Category: Toxicology Authors: Jephte Y Akakpo Anup Ramachandran Barry H Rumack Darren P Wallace Hartmut Jaeschke Source Type: research
Exploring aryl hydrocarbon receptor (AhR) as a target for Bisphenol-A (BPA)-induced pancreatic islet toxicity and impaired glucose homeostasis: protective efficacy of ethanol extract of Centella asiatica
Toxicology. 2023 Nov 30:153693. doi: 10.1016/j.tox.2023.153693. Online ahead of print.ABSTRACTThe estrogenic impact of Bisphenol-A (BPA), a widely recognized endocrine disruptor, causes disruption of pancreatic β-cell function through estrogen receptors (ERs). While BPA's binding affinity for ERs is significantly lower than that of its natural counterpart, estrogen, recent observations of BPA's affinity for aryl hydrocarbon receptor (AhR) in specific cellular contexts have sparked a specific question: does AhR play a role in BPA's toxicological effects within the endocrine pancreas? To explore this question, we investigat...
Source: Toxicology - December 2, 2023 Category: Toxicology Authors: Oly Banerjee Siddhartha Singh Shilpi Kumari Prasad Ankita Bhattacharjee Tapan Seal Jayanta Mandal Sangram Sinha Anindita Banerjee Bithin Kumar Maji Sandip Mukherjee Source Type: research
ASC/Caspase-1-activated endothelial cells pyroptosis is involved in vascular injury induced by arsenic combined with high-fat diet
Toxicology. 2023 Nov 30:153691. doi: 10.1016/j.tox.2023.153691. Online ahead of print.ABSTRACTEnvironmental arsenic (As) or high-fat diet (HFD) exposure alone are risk factors for the development of cardiovascular disease (CVDs). However, the effects and mechanisms of co-exposure to As and HFD on the cardiovascular system remain unclear. The current study aimed to investigate the combined effects of As and HFD on vascular injury and shed some light on the underlying mechanisms. The results showed that co-exposure to As and HFD resulted in a significant increase in serum lipid levels and significant lipid accumulation in th...
Source: Toxicology - December 2, 2023 Category: Toxicology Authors: Qiang Su Meng Li Lingling Yang Linhua Fan Penghui Liu Xiaodong Ying Yannan Zhao Xiaolin Tian Fengjie Tian Qian Zhao Ben Li Yi Gao Yulan Qiu Guohua Song Xiaoyan Yan Source Type: research
Application of QSAR models for acute toxicity of tetrazole compounds administrated orally and intraperitoneally in rat and mouse
In conclusion, the findings of this investigation demonstrate that the proposed QSAR models hold promise in forecasting the acute toxicity of recently developed or synthesized tetrazole compounds, thereby mitigating potential risks to human health and the environment.PMID:38042272 | DOI:10.1016/j.tox.2023.153679 (Source: Toxicology)
Source: Toxicology - December 2, 2023 Category: Toxicology Authors: Zhiyong Liu Junhong Gao Cunzhi Li Lihong Xu Xiaoqiang Lv Hui Deng Yongchao Gao Hong Wang Huan Li Zhigang Wang Source Type: research
Lack of Mitochondrial Cyp2E1 Drives Acetaminophen-induced ER Stress-mediated Apoptosis in Mouse and Human Kidneys: Inhibition by 4-Methylpyrazole but not N-Acetylcysteine
Toxicology. 2023 Nov 30:153692. doi: 10.1016/j.tox.2023.153692. Online ahead of print.ABSTRACTAcetaminophen (APAP) overdose causes liver injury and acute liver failure, as well as acute kidney injury, which is not prevented by the clinical antidote N-acetyl-L-cysteine (NAC). The absence of therapeutics targeting APAP-induced nephrotoxicity is due to gaps in understanding the mechanisms of renal injury. APAP metabolism through Cyp2E1 drives cell death in both the liver and kidney. We demonstrate that Cyp2E1 is localized to the proximal tubular cells in mouse and human kidneys. Virtually all the Cyp2E1 in kidney cells is in ...
Source: Toxicology - December 2, 2023 Category: Toxicology Authors: Jephte Y Akakpo Anup Ramachandran Barry H Rumack Darren P Wallace Hartmut Jaeschke Source Type: research
Exploring aryl hydrocarbon receptor (AhR) as a target for Bisphenol-A (BPA)-induced pancreatic islet toxicity and impaired glucose homeostasis: protective efficacy of ethanol extract of Centella asiatica
Toxicology. 2023 Nov 30:153693. doi: 10.1016/j.tox.2023.153693. Online ahead of print.ABSTRACTThe estrogenic impact of Bisphenol-A (BPA), a widely recognized endocrine disruptor, causes disruption of pancreatic β-cell function through estrogen receptors (ERs). While BPA's binding affinity for ERs is significantly lower than that of its natural counterpart, estrogen, recent observations of BPA's affinity for aryl hydrocarbon receptor (AhR) in specific cellular contexts have sparked a specific question: does AhR play a role in BPA's toxicological effects within the endocrine pancreas? To explore this question, we investigat...
Source: Toxicology - December 2, 2023 Category: Toxicology Authors: Oly Banerjee Siddhartha Singh Shilpi Kumari Prasad Ankita Bhattacharjee Tapan Seal Jayanta Mandal Sangram Sinha Anindita Banerjee Bithin Kumar Maji Sandip Mukherjee Source Type: research
ASC/Caspase-1-activated endothelial cells pyroptosis is involved in vascular injury induced by arsenic combined with high-fat diet
Toxicology. 2023 Nov 30:153691. doi: 10.1016/j.tox.2023.153691. Online ahead of print.ABSTRACTEnvironmental arsenic (As) or high-fat diet (HFD) exposure alone are risk factors for the development of cardiovascular disease (CVDs). However, the effects and mechanisms of co-exposure to As and HFD on the cardiovascular system remain unclear. The current study aimed to investigate the combined effects of As and HFD on vascular injury and shed some light on the underlying mechanisms. The results showed that co-exposure to As and HFD resulted in a significant increase in serum lipid levels and significant lipid accumulation in th...
Source: Toxicology - December 2, 2023 Category: Toxicology Authors: Qiang Su Meng Li Lingling Yang Linhua Fan Penghui Liu Xiaodong Ying Yannan Zhao Xiaolin Tian Fengjie Tian Qian Zhao Ben Li Yi Gao Yulan Qiu Guohua Song Xiaoyan Yan Source Type: research
