Etoricoxib enhances aryl hydrocarbon receptor activity
Toxicology. 2023 Oct 25:153658. doi: 10.1016/j.tox.2023.153658. Online ahead of print.ABSTRACTEtoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that possesses properties that include reducing inflammation and relieving pain and fever. Etoricoxib is an oral medication that selectively inhibits cyclooxygenase-2 with high efficacy. Controversies about its cardiovascular side effects have long existed. The aryl hydrocarbon receptor (AhR) is a cytoplasmic receptor that plays a key role in the metabolism of xenobiotics and many physiological functions. 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester ...
Source: Toxicology - October 27, 2023 Category: Toxicology Authors: Hsiao-Ho Fang Jiun Hsu Jyan-Gwo Joseph Su Source Type: research
Etoricoxib enhances aryl hydrocarbon receptor activity
Toxicology. 2023 Oct 25:153658. doi: 10.1016/j.tox.2023.153658. Online ahead of print.ABSTRACTEtoricoxib is a nonsteroidal anti-inflammatory drug (NSAID) that possesses properties that include reducing inflammation and relieving pain and fever. Etoricoxib is an oral medication that selectively inhibits cyclooxygenase-2 with high efficacy. Controversies about its cardiovascular side effects have long existed. The aryl hydrocarbon receptor (AhR) is a cytoplasmic receptor that plays a key role in the metabolism of xenobiotics and many physiological functions. 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester ...
Source: Toxicology - October 27, 2023 Category: Toxicology Authors: Hsiao-Ho Fang Jiun Hsu Jyan-Gwo Joseph Su Source Type: research
Recombinant Klotho alleviates vancomycin-induced acute kidney injury by upregulating anti-oxidative capacity via JAK2/STAT3/GPx3 axis
In conclusion, Klotho enhances antioxidant capacity through the JAK2/STAT3/GPx3 axis, which in turn improves Van-AKI.PMID:37884167 | DOI:10.1016/j.tox.2023.153657 (Source: Toxicology)
Source: Toxicology - October 26, 2023 Category: Toxicology Authors: MengMeng Wang Yue Zhou GuoXiang Hao Yue E Wu Rui Yin Yi Zheng Wei Zhao Source Type: research
Recombinant Klotho alleviates vancomycin-induced acute kidney injury by upregulating anti-oxidative capacity via JAK2/STAT3/GPx3 axis
In conclusion, Klotho enhances antioxidant capacity through the JAK2/STAT3/GPx3 axis, which in turn improves Van-AKI.PMID:37884167 | DOI:10.1016/j.tox.2023.153657 (Source: Toxicology)
Source: Toxicology - October 26, 2023 Category: Toxicology Authors: MengMeng Wang Yue Zhou GuoXiang Hao Yue E Wu Rui Yin Yi Zheng Wei Zhao Source Type: research
Assessing micro- and nanoplastics toxicity using rodent models: investigating potential mitochondrial implications
Toxicology. 2023 Oct 23:153656. doi: 10.1016/j.tox.2023.153656. Online ahead of print.ABSTRACTMitochondria's role as a central hub in cellular metabolism and signaling cascades is well established in the scientific community, being a classic marker of organisms' response to toxicant exposure. Nonetheless, little is known concerning the effects of emerging contaminants, such as microplastics, on mitochondrial metabolism. Micro- and nanoplastics present one of the major problems faced by modern societies. What was once an environmental problem is now recognized as an one-health issue, but little is known concerning microplas...
Source: Toxicology - October 25, 2023 Category: Toxicology Authors: M ónica G Silva Maria Manuel Oliveira Francisco Peixoto Source Type: research
Assessing micro- and nanoplastics toxicity using rodent models: investigating potential mitochondrial implications
Toxicology. 2023 Oct 23:153656. doi: 10.1016/j.tox.2023.153656. Online ahead of print.ABSTRACTMitochondria's role as a central hub in cellular metabolism and signaling cascades is well established in the scientific community, being a classic marker of organisms' response to toxicant exposure. Nonetheless, little is known concerning the effects of emerging contaminants, such as microplastics, on mitochondrial metabolism. Micro- and nanoplastics present one of the major problems faced by modern societies. What was once an environmental problem is now recognized as an one-health issue, but little is known concerning microplas...
Source: Toxicology - October 25, 2023 Category: Toxicology Authors: M ónica G Silva Maria Manuel Oliveira Francisco Peixoto Source Type: research
Cytomodulatory characteristics of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) against cypermethrin on skin fibroblast cells (HFF-1)
This study aimed to assess the cyto/geno protective possessions of GM-CSF on cypermethrin-induced cellular toxicity on HFF-1 cells as an in vitro model. In pre-treatment culture, cells were exposed to various GM-CSF concentrations (5, 10, 20, and 40ng/mL) with cypermethrin at IC50 (5.13ng/mL). Cytotoxicity, apoptotic rates, and genotoxicity were measured using the MTT, Annexin V-FITC/PI staining via flow-cytometry, and the comet assay. Cypermethrin at 5.13ng/mL revealed cytotoxicity, apoptosis, oxidative stress, and genotoxicity while highlighting GM-CSF's protective properties on HFF-1. GM-CSF markedly attenuated cypermet...
Source: Toxicology - October 23, 2023 Category: Toxicology Authors: Shaghayegh Aghajanshakeri Ramin Ataee Mohammad Karami Shahin Aghajanshakeri Mohammad Shokrzadeh Source Type: research
Cytomodulatory characteristics of Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) against cypermethrin on skin fibroblast cells (HFF-1)
This study aimed to assess the cyto/geno protective possessions of GM-CSF on cypermethrin-induced cellular toxicity on HFF-1 cells as an in vitro model. In pre-treatment culture, cells were exposed to various GM-CSF concentrations (5, 10, 20, and 40ng/mL) with cypermethrin at IC50 (5.13ng/mL). Cytotoxicity, apoptotic rates, and genotoxicity were measured using the MTT, Annexin V-FITC/PI staining via flow-cytometry, and the comet assay. Cypermethrin at 5.13ng/mL revealed cytotoxicity, apoptosis, oxidative stress, and genotoxicity while highlighting GM-CSF's protective properties on HFF-1. GM-CSF markedly attenuated cypermet...
Source: Toxicology - October 23, 2023 Category: Toxicology Authors: Shaghayegh Aghajanshakeri Ramin Ataee Mohammad Karami Shahin Aghajanshakeri Mohammad Shokrzadeh Source Type: research
Lead exposure induces neuronal apoptosis via NF κB p65/RBBP4/Survivin signaling pathway
Toxicology. 2023 Oct 20:153654. doi: 10.1016/j.tox.2023.153654. Online ahead of print.ABSTRACTLead (Pb), as a heavy metal that is easily exposed in daily life, can cause damage to various systems of body. Apoptosis is an autonomous cell death process regulated by genes in order to maintain the stability of internal environment, which plays an important role in the development of nervous system. RB binding protein 4 (RBBP4) is one of the core histone binding subunits and is closely related to the apoptosis process of nervous system cells. However, it is not known whether RBBP4 can regulate neuronal apoptosis in lead-exposed...
Source: Toxicology - October 22, 2023 Category: Toxicology Authors: Hui Chen Wei Zhang Song Luo Yanshu Li Qian Zhu Yongli Xia Hong Tan Ying Bian Yaobing Li Jianmin Ma Wei Chen Xietian Luo Gaochun Zhu Source Type: research
Lead exposure induces neuronal apoptosis via NF κB p65/RBBP4/Survivin signaling pathway
Toxicology. 2023 Oct 20:153654. doi: 10.1016/j.tox.2023.153654. Online ahead of print.ABSTRACTLead (Pb), as a heavy metal that is easily exposed in daily life, can cause damage to various systems of body. Apoptosis is an autonomous cell death process regulated by genes in order to maintain the stability of internal environment, which plays an important role in the development of nervous system. RB binding protein 4 (RBBP4) is one of the core histone binding subunits and is closely related to the apoptosis process of nervous system cells. However, it is not known whether RBBP4 can regulate neuronal apoptosis in lead-exposed...
Source: Toxicology - October 22, 2023 Category: Toxicology Authors: Hui Chen Wei Zhang Song Luo Yanshu Li Qian Zhu Yongli Xia Hong Tan Ying Bian Yaobing Li Jianmin Ma Wei Chen Xietian Luo Gaochun Zhu Source Type: research
Restoration of PM2.5-induced spermatogonia GC-1 cellular damage by parthenolide via suppression of autophagy and inflammation: An in vitro study
Toxicology. 2023 Oct 17;499:153651. doi: 10.1016/j.tox.2023.153651. Online ahead of print.ABSTRACTParticulate matter (PM) generated by environmental and air pollution is known to have detrimental effects on human health. Among these, PM2.5 particles (diameter < 2.5 µm) can breach the alveolar-capillary barrier and disseminate to other organs, posing significant health risks. Numerous studies have shown that PMs can harm various organs, including the reproductive system. Therefore, this study aimed to investigate the harmful effects of PM2.5 on mouse GC-1 spermatogonia cells (GC-1 spg cells) and to verify the ameliorati...
Source: Toxicology - October 20, 2023 Category: Toxicology Authors: Hyo Jin Gu Jin Seop Ahn Gi Jeong Ahn Seung Hee Shin Buom-Yong Ryu Source Type: research
Subchronic exposure to Di-(2-ethylhexyl) phthalate (DEHP) elicits blood-brain barrier dysfunction and cerebral inflammation in male C57BL/6J mice
The objective is to investigate the potential effects of subchronic DEHP exposure on BBB integrity and discuss the role of BBB in DEHP inducible neurotoxicity with an emphasis on neuroinflammatory responses. Male adult C57BL/6Jcnc mice were orally administered vehicle or 200 or 750mg/kg/day DEHP for 90 days. Subchronic exposure to high-dose DEHP increased water intake but decreased body weight and brain weight. The concentrations of DEHP metabolites increased in serum from DEHP-exposed groups, whereas these increased in brain tissues only from the high-dose group. DEHP induced neurobehavioural alterations and damaged neuro...
Source: Toxicology - October 20, 2023 Category: Toxicology Authors: Wen-Qiang Ren Nuo Liu Yan Shen Xian-Yan Wang Qiong Zhou Chen Rui Xiao-Han Yang Sheng-Long Cao Ling-Yu Li Yan Wang Qu-Nan Wang Source Type: research
Synergism in actions of HBV with aflatoxin in cancer development
Toxicology. 2023 Oct 17:153652. doi: 10.1016/j.tox.2023.153652. Online ahead of print.ABSTRACTAflatoxin B1 (AFB1) is a fungal metabolite found in animal feeds and human foods. It is one of the most toxic and carcinogenic of aflatoxins and is classified as a Group 1 carcinogen. Dietary exposure to AFB1 and infection with chronic Hepatitis B Virus (HBV) make up two of the major risk factors for hepatocellular carcinoma (HCC). These two major risk factors raise the probability of synergism between the two agents. This review proposes some collaborative molecular mechanisms underlying the interaction between AFB1 and HBV in ac...
Source: Toxicology - October 20, 2023 Category: Toxicology Authors: Joshua Jin Valentina L Kouznetsova Santosh Kesari Igor F Tsigelny Source Type: research
Increasing Confidence in New Approach Methodologies for Inhalation Risk Assessment with Multiple End Point Assays Using 5-day Repeated Exposure to 1,3-dichloropropene
Toxicology. 2023 Oct 18:153642. doi: 10.1016/j.tox.2023.153642. Online ahead of print.ABSTRACTNew Approach Methodologies (NAMs) are being widely used to reduce, refine, and replace, animal use in studying toxicology. For respiratory toxicology, this includes both in silico and in vitro alternatives to replace traditional in vivo inhalation studies. 1,3-Dichloropropene (1,3-DCP) is a volatile organic compound that is widely used in agriculture as a pre-planting fumigant. Short-term exposure of humans to 1,3-DCP can result in mucous membrane irritation, chest pain, headache, and dizziness. In our previous work, we exposed di...
Source: Toxicology - October 20, 2023 Category: Toxicology Authors: Iru Paudel A Rasim Barutcu Raymond Samuel Marjory Moreau Scott D Slattery Leslie Recio Source Type: research
Role of myo-inositol in acute kidney injury induced by cisplatin
In this study, we aimed to explore the role of MI in cisplatin-induced acute kidney injury (AKI). We established a model of acute kidney injury caused by cisplatin (CDDP). Male Kunming mice were randomly divided into six groups: Sham (normal saline), CDDP (15mg/kg), + MI (150mg/kg), + MI (300mg/kg), + MI (600mg/kg) and MI (600mg/kg). Human renal tubular epithelial cell line HK-2 cells were likewise separated into six groups at random: Control (normal saline), CDDP (20µM), + MI (200µM), + MI (400µM), + MI (800µM) and MI (800µM). After the model was established, renal function indexes were subsequently detected, and exp...
Source: Toxicology - October 20, 2023 Category: Toxicology Authors: Yu-Hong Xie Ling Wang Ming-Liang Li Zhi-Cheng Gong Jie Du Source Type: research
