Reproductive toxicity of cadmium stress in male animals
Toxicology. 2024 Mar 22:153787. doi: 10.1016/j.tox.2024.153787. Online ahead of print.ABSTRACTCadmium (Cd) is a common heavy metal pollutant in the environment, and the widespread use of products containing Cd compounds in industry has led to excessive levels in the environment, which enter the animal body through the food chain, thus seriously affecting the reproductive development of animals. Related studies have reported that Cd severely affects spermatogonia development and spermatogenesis in animals. In contrast, the reproductive toxicity of Cd in males and its mechanism of action have not been clarified. Therefore, t...
Source: Toxicology - March 24, 2024 Category: Toxicology Authors: Zikun Zhang Qi Wang Xiaoge Gao Xu Tang Huan Xu Wenqiang Wang Xin Lei Source Type: research
Effect of modified citrus pectin on galectin-3 inhibition in cisplatin-induced cardiac and renal toxicity
In conclusion, MCP therapy in the acute model of cisplatin-induced toxicity increases oxidative stress in cardiac and renal tissues. Further investigations are needed to determine the beneficial and harmful roles of Gal-3 in the cardiorenal system since it can act differently in acute and chronic diseases/conditions.PMID:38522819 | DOI:10.1016/j.tox.2024.153786 (Source: Toxicology)
Source: Toxicology - March 24, 2024 Category: Toxicology Authors: Diego D Santos Nycole M Belote Gisela R S Sasso Rebeca D Correia-Silva Paulo C Franco Artur Francisco da Silva Neto Fernanda T Borges Lila M Oyama Cristiane D Gil Source Type: research
Chlorpyrifos impairs sperm parameters and number of Sertoli and Leydig cells in rats after exposure during the peripubertal period
Toxicology. 2024 Mar 22:153789. doi: 10.1016/j.tox.2024.153789. Online ahead of print.ABSTRACTChlorpyrifos is an organophosphate insecticide used to control pests in crops. Thus, humans are constantly exposed through ingestion of contaminated food or water, inhalation of contaminated air, and through the skin. The juvenile and peripubertal periods comprise a window of development of the reproductive system, sensitive to toxic agents. Considering the scarcity of data on exposure to the insecticide during these periods, the aim of this study was to evaluate the effects of chlorpyrifos on the testis during the juvenile and pe...
Source: Toxicology - March 24, 2024 Category: Toxicology Authors: Ivana Regina da Costa D ébora Hipólito Quadreli Lucas Marcelo Meira da Silva F ábio Goulart de Andrade Glaura Scantamburlo Alves Fernandes Source Type: research
Environmental Toxicants and Nephrotoxicity: Implications on Mechanisms and Therapeutic Strategies
This study uncovers the potential for new insights concerning the relationship between various environmental toxicants and kidney health. The objectives of this review is to establish information gaps, assess and identify the toxicity mechanisms of different nephrotoxicants, identify innovative pharmacological therapies that demonstrate promising therapeutic benefits and relevance, and discuss the predictions for the future based on the analysis of the literature.PMID:38518838 | DOI:10.1016/j.tox.2024.153784 (Source: Toxicology)
Source: Toxicology - March 22, 2024 Category: Toxicology Authors: Rachna Yadav Dinesh Kumar Jiten Singh Ashok Jangra Source Type: research
High-throughput screening of respiratory hazards: Exploring lung surfactant inhibition with 20 benchmark chemicals
This study employed a constrained drop surfactometer to assess 20 chemicals for potential surfactant inhibition. Of these, eight were identified as inhibiting lung surfactant function: 1-aminoethanol, bovine serum albumin, maleic anhydride, propylene glycol, sodium glycocholate, sodium taurocholate, sodium taurodeoxycholate, and Triton X-100. These results are consistent with previously reported chemical-induced acute lung dysfunction in vivo. The study provides information on each chemical's minimum and maximum surface tension conditions and corresponding relative area and contact angle values. Isotherms and box plots are...
Source: Toxicology - March 22, 2024 Category: Toxicology Authors: James Y Liu Ian C George Saber Hussain Christie M Sayes Source Type: research
Comparative toxicological analysis of two pristine carbon nanomaterials (graphene oxide and aminated graphene oxide) and their corresponding degraded forms using human in vitro models
Toxicology. 2024 Mar 20:153783. doi: 10.1016/j.tox.2024.153783. Online ahead of print.ABSTRACTDespite the wide application of graphene-based materials, the information of the toxicity associated to some specific derivatives such as aminated graphene oxide is scarce. Likewise, most of these studies analyse the pristine materials, while the available data regarding the harmful effects of degraded forms is very limited. In this work, the toxicity of graphene oxide (GO), aminated graphene oxide (GO-NH2), and their respective degraded forms (dGO and dGO-NH2) obtained after being submitted to high-intensity sonication was evalua...
Source: Toxicology - March 22, 2024 Category: Toxicology Authors: Sandra de la Parra Natalia Fern ández-Pampín Sebastiano Garroni Matteo Poddighe Dalia de la Fuente-Vivas Roc ío Barros Sonia Martel-Mart ín Santiago Aparicio Carlos Rumbo Juan Antonio Tamayo-Ramos Source Type: research
Environmental Toxicants and Nephrotoxicity: Implications on Mechanisms and Therapeutic Strategies
This study uncovers the potential for new insights concerning the relationship between various environmental toxicants and kidney health. The objectives of this review is to establish information gaps, assess and identify the toxicity mechanisms of different nephrotoxicants, identify innovative pharmacological therapies that demonstrate promising therapeutic benefits and relevance, and discuss the predictions for the future based on the analysis of the literature.PMID:38518838 | DOI:10.1016/j.tox.2024.153784 (Source: Toxicology)
Source: Toxicology - March 22, 2024 Category: Toxicology Authors: Rachna Yadav Dinesh Kumar Jiten Singh Ashok Jangra Source Type: research
High-throughput screening of respiratory hazards: Exploring lung surfactant inhibition with 20 benchmark chemicals
This study employed a constrained drop surfactometer to assess 20 chemicals for potential surfactant inhibition. Of these, eight were identified as inhibiting lung surfactant function: 1-aminoethanol, bovine serum albumin, maleic anhydride, propylene glycol, sodium glycocholate, sodium taurocholate, sodium taurodeoxycholate, and Triton X-100. These results are consistent with previously reported chemical-induced acute lung dysfunction in vivo. The study provides information on each chemical's minimum and maximum surface tension conditions and corresponding relative area and contact angle values. Isotherms and box plots are...
Source: Toxicology - March 22, 2024 Category: Toxicology Authors: James Y Liu Ian C George Saber Hussain Christie M Sayes Source Type: research
Comparative toxicological analysis of two pristine carbon nanomaterials (graphene oxide and aminated graphene oxide) and their corresponding degraded forms using human in vitro models
Toxicology. 2024 Mar 20:153783. doi: 10.1016/j.tox.2024.153783. Online ahead of print.ABSTRACTDespite the wide application of graphene-based materials, the information of the toxicity associated to some specific derivatives such as aminated graphene oxide is scarce. Likewise, most of these studies analyse the pristine materials, while the available data regarding the harmful effects of degraded forms is very limited. In this work, the toxicity of graphene oxide (GO), aminated graphene oxide (GO-NH2), and their respective degraded forms (dGO and dGO-NH2) obtained after being submitted to high-intensity sonication was evalua...
Source: Toxicology - March 22, 2024 Category: Toxicology Authors: Sandra de la Parra Natalia Fern ández-Pampín Sebastiano Garroni Matteo Poddighe Dalia de la Fuente-Vivas Roc ío Barros Sonia Martel-Mart ín Santiago Aparicio Carlos Rumbo Juan Antonio Tamayo-Ramos Source Type: research
Single-cell and multi-omics analyses highlight cancer-associated fibroblasts-induced immune evasion and epithelial mesenchymal transition for smoking bladder cancer
Toxicology. 2024 Mar 16;504:153782. doi: 10.1016/j.tox.2024.153782. Online ahead of print.ABSTRACTTobacco carcinogens are recognized as critical hazard factors for bladder tumorigenesis, affecting the prognosis of patients through aromatic amines components. However, the specific function of tobacco carcinogens and systematic assessment models in the prognosis of bladder cancer remains poorly elucidated. We retrieved bladder cancer specific tobacco carcinogens-related genes from Comparative Toxicogenomic Database, our Nanjing Bladder Cancer cohort and TCGA database. Gene×Gene interaction method was utilized to establish a...
Source: Toxicology - March 17, 2024 Category: Toxicology Authors: Jiajin Wu Fang Gao Rui Meng Huiqin Li Zhenguang Mao Yanping Xiao Qiuyi Pu Mulong Du Zhengdong Zhang Qiang Shao Rui Zheng Meilin Wang Source Type: research
A review on toxicity mechanism and risk factors of nanoparticles in respiratory tract
Toxicology. 2024 Mar 15:153781. doi: 10.1016/j.tox.2024.153781. Online ahead of print.ABSTRACTThis comprehensive review focuses on various dimensions of nanoparticle toxicity, emphasizing toxicological characteristics, assessment techniques, and examinations of relevant studies on the effects on biological systems. The primary objective is to comprehend the potential risks associated with nanoparticles and to provide efficient strategies for mitigating them by consolidating current research discoveries. For in-depth insights, the discussions extend to crucial aspects such as toxicity associated with different nanoparticles...
Source: Toxicology - March 17, 2024 Category: Toxicology Authors: Vidyasri Khadanga Purna Chandra Mishra Source Type: research
Single-cell and multi-omics analyses highlight cancer-associated fibroblasts-induced immune evasion and epithelial mesenchymal transition for smoking bladder cancer
Toxicology. 2024 Mar 16;504:153782. doi: 10.1016/j.tox.2024.153782. Online ahead of print.ABSTRACTTobacco carcinogens are recognized as critical hazard factors for bladder tumorigenesis, affecting the prognosis of patients through aromatic amines components. However, the specific function of tobacco carcinogens and systematic assessment models in the prognosis of bladder cancer remains poorly elucidated. We retrieved bladder cancer specific tobacco carcinogens-related genes from Comparative Toxicogenomic Database, our Nanjing Bladder Cancer cohort and TCGA database. Gene×Gene interaction method was utilized to establish a...
Source: Toxicology - March 17, 2024 Category: Toxicology Authors: Jiajin Wu Fang Gao Rui Meng Huiqin Li Zhenguang Mao Yanping Xiao Qiuyi Pu Mulong Du Zhengdong Zhang Qiang Shao Rui Zheng Meilin Wang Source Type: research
A review on toxicity mechanism and risk factors of nanoparticles in respiratory tract
Toxicology. 2024 Mar 15:153781. doi: 10.1016/j.tox.2024.153781. Online ahead of print.ABSTRACTThis comprehensive review focuses on various dimensions of nanoparticle toxicity, emphasizing toxicological characteristics, assessment techniques, and examinations of relevant studies on the effects on biological systems. The primary objective is to comprehend the potential risks associated with nanoparticles and to provide efficient strategies for mitigating them by consolidating current research discoveries. For in-depth insights, the discussions extend to crucial aspects such as toxicity associated with different nanoparticles...
Source: Toxicology - March 17, 2024 Category: Toxicology Authors: Vidyasri Khadanga Purna Chandra Mishra Source Type: research
Single-cell and multi-omics analyses highlight cancer-associated fibroblasts-induced immune evasion and epithelial mesenchymal transition for smoking bladder cancer
Toxicology. 2024 Mar 15:153782. doi: 10.1016/j.tox.2024.153782. Online ahead of print.ABSTRACTTobacco carcinogens are recognized as critical hazard factors for bladder tumorigenesis, affecting the prognosis of patients through aromatic amines components. However, the specific function of tobacco carcinogens and systematic assessment models in the prognosis of bladder cancer remains poorly elucidated. We retrieved bladder cancer specific tobacco carcinogens-related genes from Comparative Toxicogenomic Database, our Nanjing Bladder Cancer cohort and TCGA database. Gene×gene interaction method was utilized to establish a pro...
Source: Toxicology - March 17, 2024 Category: Toxicology Authors: Jiajin Wu Fang Gao Rui Meng Huiqin Li Zhenguang Mao Yanping Xiao Qiuyi Pu Mulong Du Zhengdong Zhang Qiang Shao Rui Zheng Meilin Wang Source Type: research
A review on toxicity mechanism and risk factors of nanoparticles in respiratory tract
Toxicology. 2024 Mar 15:153781. doi: 10.1016/j.tox.2024.153781. Online ahead of print.ABSTRACTThis comprehensive review focuses on various dimensions of nanoparticle toxicity, emphasizing toxicological characteristics, assessment techniques, and examinations of relevant studies on the effects on biological systems. The primary objective is to comprehend the potential risks associated with nanoparticles and to provide efficient strategies for mitigating them by consolidating current research discoveries. For in-depth insights, the discussions extend to crucial aspects such as toxicity associated with different nanoparticles...
Source: Toxicology - March 17, 2024 Category: Toxicology Authors: Vidyasri Khadanga Purna Chandra Mishra Source Type: research
