Comprehensive analysis of the impact of emerging flame retardants on prostate cancer progression: The potential molecular mechanisms and immune infiltration landscape
Toxicology. 2023 Nov 23:153681. doi: 10.1016/j.tox.2023.153681. Online ahead of print.ABSTRACTEmerging flame retardants have been used to replace traditional flame retardants, but their potential impact on cancer, especially prostate cancer, is not well understood. Our study aimed to explore the link between flame retardants and prostate cancer, and identify potential carcinogenic mechanisms among populations exposed to emerging flame retardants. We screened flame retardant interacting genes differentially expressed in prostate cancer patients and identified hub genes by protein-protein interaction (PPI) analysis based on ...
Source: Toxicology - November 25, 2023 Category: Toxicology Authors: Xinchi Xu Dong Zhang Kai Zhao Zhanpeng Liu Xiaohan Ren Xu Zhang Zhongwen Lu Chao Qin Jiawei Wang Shangqian Wang Source Type: research
Examining the immunotoxicity of oil sands process affected waters using a human macrophage cell line
Toxicology. 2023 Nov 23;500:153680. doi: 10.1016/j.tox.2023.153680. Online ahead of print.ABSTRACTOil sands process affected water (OSPW) is produced during the surface mining of the oil sands bitumen deposits in Northern Alberta. OSPW contains variable quantities of organic and inorganic components causing toxic effects on living organisms. Advanced Oxidation Processes (AOPs) are widely used to degrade toxic organic components from OSPW including naphthenic acids (NAs). However, there is no established biological procedure to assess the effectiveness of the remediation processes. Our previous study showed that human macro...
Source: Toxicology - November 25, 2023 Category: Toxicology Authors: Sunanda Paul Nora A S Hussain Dustin M E Lillico Monsuru A Suara Soliu O Ganiyu Mohamed Gamal El-Din James L Stafford Source Type: research
Bisphenol A induced neuronal apoptosis and enhanced autophagy in vitro through Nrf2/HO-1 and Akt/mTOR pathways
Toxicology. 2023 Nov 23:153678. doi: 10.1016/j.tox.2023.153678. Online ahead of print.ABSTRACTBisphenol A (BPA) was traditionally used in epoxy resins and polycarbonate plastics, but it was found to be harmful to human health due to its endocrine-disrupting effects. It can affect various biological functions of human beings and interfere with brain development. However, the neurotoxic mechanisms of BPA on brain development and associated neurodegeneration remain poorly understood. Here, we reported that BPA (100, 250, 500μM) inhibited cell viability of neural cells PC12, SH-SY5Y and caused dose-dependent cell death. In ad...
Source: Toxicology - November 25, 2023 Category: Toxicology Authors: Yue Shen Xinying Li Hongyan Wang Yicheng Wang Liqing Tao Pingping Wang Heng Zhang Source Type: research
The variability in CYP3A4 activity determines the metabolic kinetic characteristics of ketamine
In conclusion, variations in CYP3A4 activity would result in the stratification of ketamine blood exposure.PMID:38006927 | DOI:10.1016/j.tox.2023.153682 (Source: Toxicology)
Source: Toxicology - November 25, 2023 Category: Toxicology Authors: Mengfang Li Qingqing Li Dan Lin Xiang Zheng Lehao Jin Jianping Cai Guoxin Hu Jianchang Qian Source Type: research
Comprehensive analysis of the impact of emerging flame retardants on prostate cancer progression: The potential molecular mechanisms and immune infiltration landscape
Toxicology. 2023 Nov 23:153681. doi: 10.1016/j.tox.2023.153681. Online ahead of print.ABSTRACTEmerging flame retardants have been used to replace traditional flame retardants, but their potential impact on cancer, especially prostate cancer, is not well understood. Our study aimed to explore the link between flame retardants and prostate cancer, and identify potential carcinogenic mechanisms among populations exposed to emerging flame retardants. We screened flame retardant interacting genes differentially expressed in prostate cancer patients and identified hub genes by protein-protein interaction (PPI) analysis based on ...
Source: Toxicology - November 25, 2023 Category: Toxicology Authors: Xinchi Xu Dong Zhang Kai Zhao Zhanpeng Liu Xiaohan Ren Xu Zhang Zhongwen Lu Chao Qin Jiawei Wang Shangqian Wang Source Type: research
Examining the immunotoxicity of oil sands process affected waters using a human macrophage cell line
Toxicology. 2023 Nov 23:153680. doi: 10.1016/j.tox.2023.153680. Online ahead of print.ABSTRACTOil sands process affected water (OSPW) is produced during the surface mining of the oil sands bitumen deposits in Northern Alberta. OSPW contains variable quantities of organic and inorganic components causing toxic effects on living organisms. Advanced Oxidation Processes (AOPs) are widely used to degrade toxic organic components from OSPW including naphthenic acids (NAs). However, there is no established biological procedure to assess the effectiveness of the remediation processes. Our previous study showed that human macrophag...
Source: Toxicology - November 25, 2023 Category: Toxicology Authors: Sunanda Paul Nora A S Hussain Dustin M E Lillico Monsuru A Suara Soliu O Ganiyu Mohamed Gamal El-Din James L Stafford Source Type: research
Bisphenol A induced neuronal apoptosis and enhanced autophagy in vitro through Nrf2/HO-1 and Akt/mTOR pathways
Toxicology. 2023 Nov 23:153678. doi: 10.1016/j.tox.2023.153678. Online ahead of print.ABSTRACTBisphenol A (BPA) was traditionally used in epoxy resins and polycarbonate plastics, but it was found to be harmful to human health due to its endocrine-disrupting effects. It can affect various biological functions of human beings and interfere with brain development. However, the neurotoxic mechanisms of BPA on brain development and associated neurodegeneration remain poorly understood. Here, we reported that BPA (100, 250, 500μM) inhibited cell viability of neural cells PC12, SH-SY5Y and caused dose-dependent cell death. In ad...
Source: Toxicology - November 25, 2023 Category: Toxicology Authors: Yue Shen Xinying Li Hongyan Wang Yicheng Wang Liqing Tao Pingping Wang Heng Zhang Source Type: research
The variability in CYP3A4 activity determines the metabolic kinetic characteristics of ketamine
In conclusion, variations in CYP3A4 activity would result in the stratification of ketamine blood exposure.PMID:38006927 | DOI:10.1016/j.tox.2023.153682 (Source: Toxicology)
Source: Toxicology - November 25, 2023 Category: Toxicology Authors: Mengfang Li Qingqing Li Dan Lin Xiang Zheng Lehao Jin Jianping Cai Guoxin Hu Jianchang Qian Source Type: research
Comprehensive analysis of the impact of emerging flame retardants on prostate cancer progression: The potential molecular mechanisms and immune infiltration landscape
Toxicology. 2023 Nov 23:153681. doi: 10.1016/j.tox.2023.153681. Online ahead of print.ABSTRACTEmerging flame retardants have been used to replace traditional flame retardants, but their potential impact on cancer, especially prostate cancer, is not well understood. Our study aimed to explore the link between flame retardants and prostate cancer, and identify potential carcinogenic mechanisms among populations exposed to emerging flame retardants. We screened flame retardant interacting genes differentially expressed in prostate cancer patients and identified hub genes by protein-protein interaction (PPI) analysis based on ...
Source: Toxicology - November 25, 2023 Category: Toxicology Authors: Xinchi Xu Dong Zhang Kai Zhao Zhanpeng Liu Xiaohan Ren Xu Zhang Zhongwen Lu Chao Qin Jiawei Wang Shangqian Wang Source Type: research
Examining the immunotoxicity of oil sands process affected waters using a human macrophage cell line
Toxicology. 2023 Nov 23:153680. doi: 10.1016/j.tox.2023.153680. Online ahead of print.ABSTRACTOil sands process affected water (OSPW) is produced during the surface mining of the oil sands bitumen deposits in Northern Alberta. OSPW contains variable quantities of organic and inorganic components causing toxic effects on living organisms. Advanced Oxidation Processes (AOPs) are widely used to degrade toxic organic components from OSPW including naphthenic acids (NAs). However, there is no established biological procedure to assess the effectiveness of the remediation processes. Our previous study showed that human macrophag...
Source: Toxicology - November 25, 2023 Category: Toxicology Authors: Sunanda Paul Nora A S Hussain Dustin M E Lillico Monsuru A Suara Soliu O Ganiyu Mohamed Gamal El-Din James L Stafford Source Type: research
Bisphenol A induced neuronal apoptosis and enhanced autophagy in vitro through Nrf2/HO-1 and Akt/mTOR pathways
Toxicology. 2023 Nov 23:153678. doi: 10.1016/j.tox.2023.153678. Online ahead of print.ABSTRACTBisphenol A (BPA) was traditionally used in epoxy resins and polycarbonate plastics, but it was found to be harmful to human health due to its endocrine-disrupting effects. It can affect various biological functions of human beings and interfere with brain development. However, the neurotoxic mechanisms of BPA on brain development and associated neurodegeneration remain poorly understood. Here, we reported that BPA (100, 250, 500μM) inhibited cell viability of neural cells PC12, SH-SY5Y and caused dose-dependent cell death. In ad...
Source: Toxicology - November 25, 2023 Category: Toxicology Authors: Yue Shen Xinying Li Hongyan Wang Yicheng Wang Liqing Tao Pingping Wang Heng Zhang Source Type: research
Use of a Polymeric Implant System to Assess the Neurotoxicity of Subacute Exposure to 2,2',5,5'-Tetrachlorobiphenyl-4-ol, a Human Metabolite of PCB 52, in Male Adolescent Rats
In this study, we evaluated the subacute neurotoxicity of a human-relevant metabolite, 2,2',5,5'-tetrachlorobiphenyl-4-ol (4-52), on male adolescent Sprague Dawley rats, via a novel polymeric implant drug delivery system grafted subcutaneously, at total loading concentrations ranging from 0%, 1%, 5%, and 10% of the implant (w/w) for 28 days. Y-maze, hole board test, open field test, and elevated plus maze were performed on exposure days 24 to 28 to assess their locomotor activity, and exploratory and anxiety-like behavior. 4-52 and other possible hydroxylated metabolites in serum and vital tissues were quantified using gas...
Source: Toxicology - November 23, 2023 Category: Toxicology Authors: Hui Wang Amanda J Bullert Xueshu Li Hanna Stevens Aloysius J Klingelhutz James A Ankrum Andrea Adamcakova-Dodd Peter S Thorne Hans-Joachim Lehmler Source Type: research
Use of a Polymeric Implant System to Assess the Neurotoxicity of Subacute Exposure to 2,2',5,5'-Tetrachlorobiphenyl-4-ol, a Human Metabolite of PCB 52, in Male Adolescent Rats
In this study, we evaluated the subacute neurotoxicity of a human-relevant metabolite, 2,2',5,5'-tetrachlorobiphenyl-4-ol (4-52), on male adolescent Sprague Dawley rats, via a novel polymeric implant drug delivery system grafted subcutaneously, at total loading concentrations ranging from 0%, 1%, 5%, and 10% of the implant (w/w) for 28 days. Y-maze, hole board test, open field test, and elevated plus maze were performed on exposure days 24 to 28 to assess their locomotor activity, and exploratory and anxiety-like behavior. 4-52 and other possible hydroxylated metabolites in serum and vital tissues were quantified using gas...
Source: Toxicology - November 23, 2023 Category: Toxicology Authors: Hui Wang Amanda J Bullert Xueshu Li Hanna Stevens Aloysius J Klingelhutz James A Ankrum Andrea Adamcakova-Dodd Peter S Thorne Hans-Joachim Lehmler Source Type: research
Secreted cyclophilin A is non-genotoxic but acts as a tumor promoter
Toxicology. 2023 Nov 20;500:153675. doi: 10.1016/j.tox.2023.153675. Online ahead of print.ABSTRACTChronic inflammation is associated with malignant transformation and creates the microenvironment for tumor progression. Cyclophilin A (CypA) is one of the major pro-inflammatory mediators that accumulates and persists in the site of inflammation in high doses over time. According to multiomics analyses of transformed cells, CypA is widely recognized as a pro-oncogenic factor. Vast experimental data define the functions of intracellular CypA in carcinogenesis, but findings on the role of its secreted form in tumor formation an...
Source: Toxicology - November 22, 2023 Category: Toxicology Authors: Anastasiia Kalinina Leila Tilova Kirill Kirsanov Ekaterina Lesovaya Ekaterina Zhidkova Timur Fetisov Galina Ilyinskaya Marianna Yakubovskaya Dmitry Kazansky Ludmila Khromykh Source Type: research
Development of a read-across-derived classification model for the predictions of mutagenicity data and its comparison with traditional QSAR models and expert systems
Toxicology. 2023 Nov 21;500:153676. doi: 10.1016/j.tox.2023.153676. Online ahead of print.ABSTRACTMutagenicity is considered an important endpoint from the regulatory, environmental and medical points of view. Due to the wide number of compounds that may be of concern and the enormous expenses (in terms of time, money, and animals) associated with rodent mutagenicity bioassays, this endpoint is a major target for the development of alternative approaches for screening and prediction. The majority of old-aged expert systems and quantitative structure-activity relationship (QSAR) models may show reduced performance over time...
Source: Toxicology - November 22, 2023 Category: Toxicology Authors: Sapna Kumari Pandey Kunal Roy Source Type: research
