Prediction of Acute Methanol Poisoning Prognosis Using machine learning techniques
This study focuses on predicting the severity of methanol intoxication using machine learning techniques, aiming to improve early identification and prognosis assessment. The study, conducted at Loghman Hakim Hospital in Tehran, Iran. The data pertaining to individuals afflicted with methanol poisoning was retrieved retrospectively and divided into training and test groups at a ratio of 70:30. The selected features were then inputted into various machine learning methods. The models were implemented using the Scikit-learn library in the Python programming language. Ultimately, the efficacy of the developed models was asses...
Source: Toxicology - March 8, 2024 Category: Toxicology Authors: Mitra Rahimi Sayed Masoud Hosseini Seyed Ali Mohtarami Babak Mostafazadeh Peyman Erfan Talab Evini Mobin Fathy Arya Kazemi Sina Khani Seyed Mohammad Mortazavi Amirali Soheili Seyed Mohammad Vahabi Shahin Shadnia Source Type: research
Influence of lead-induced toxicity on the inflammatory cytokines
Toxicology. 2024 Mar 5:153771. doi: 10.1016/j.tox.2024.153771. Online ahead of print.ABSTRACTLead (Pb2+) is a hazardous heavy metal that is pervasive in the human environment as a result of anthropogenic activity, and poses serious health risks, particularly in children. Due to its innumerable unique physical and chemical properties, it has various applications; therefore, it has become a common environmental pollutant. Lead may cause oxidative stress, and accumulating evidence indicates that oxidative stress influences the pathophysiology of lead poisoning, also called plumbism. The immune system is continually exposed to...
Source: Toxicology - March 7, 2024 Category: Toxicology Authors: P Harshitha Kalpita Bose Herman Sunil Dsouza Source Type: research
Influence of lead-induced toxicity on the inflammatory cytokines
Toxicology. 2024 Mar 5:153771. doi: 10.1016/j.tox.2024.153771. Online ahead of print.ABSTRACTLead (Pb2+) is a hazardous heavy metal that is pervasive in the human environment as a result of anthropogenic activity, and poses serious health risks, particularly in children. Due to its innumerable unique physical and chemical properties, it has various applications; therefore, it has become a common environmental pollutant. Lead may cause oxidative stress, and accumulating evidence indicates that oxidative stress influences the pathophysiology of lead poisoning, also called plumbism. The immune system is continually exposed to...
Source: Toxicology - March 7, 2024 Category: Toxicology Authors: P Harshitha Kalpita Bose Herman Sunil Dsouza Source Type: research
Bee venom genotoxicity on Saccharomyces cerevisiae cells - The role of mitochondria and YAP1 transcription factor
Toxicology. 2024 Mar 3;503:153768. doi: 10.1016/j.tox.2024.153768. Online ahead of print.ABSTRACTThe present work aims to clarify the genotype differences of a model organism Saccharomyces cerevisiae in response to bee venom. The study evaluated various endpoints including cell survival, induction of physiologically active superoxide anions, mitotic gene conversion, mitotic crossing-over, reverse mutations, DNA double-strand breaks, and Ty1 retrotransposition. The role of the intact mitochondria and the YAP1 transcription factor was also evaluated. Our results indicate a genotype-specific response. The first experimental e...
Source: Toxicology - March 5, 2024 Category: Toxicology Authors: Teodora Todorova Krassimir Boyadzhiev Martin Dimitrov Petya Parvanova Source Type: research
Bee venom genotoxicity on Saccharomyces cerevisiae cells - The role of mitochondria and YAP1 transcription factor
Toxicology. 2024 Mar 3;503:153768. doi: 10.1016/j.tox.2024.153768. Online ahead of print.ABSTRACTThe present work aims to clarify the genotype differences of a model organism Saccharomyces cerevisiae in response to bee venom. The study evaluated various endpoints including cell survival, induction of physiologically active superoxide anions, mitotic gene conversion, mitotic crossing-over, reverse mutations, DNA double-strand breaks, and Ty1 retrotransposition. The role of the intact mitochondria and the YAP1 transcription factor was also evaluated. Our results indicate a genotype-specific response. The first experimental e...
Source: Toxicology - March 5, 2024 Category: Toxicology Authors: Teodora Todorova Krassimir Boyadzhiev Martin Dimitrov Petya Parvanova Source Type: research
Ferrostatin ‑1 alleviates liver injury via decreasing ferroptosis following ricin toxin poisoning in rat
Toxicology. 2024 Mar 2:153767. doi: 10.1016/j.tox.2024.153767. Online ahead of print.ABSTRACTRicin is a highly toxic plant toxin that can cause multi-organ failure, especially liver dysfunction, and is a potential bioterrorism agent. Despite the serious public health challenge posed by ricin, effective therapeutic for ricin-induced poisoning is currently unavailable. Therefore, it is important to explore the mechanism of ricin poisoning and develop appropriate treatment protocols accordingly. Previous studies have shown that lipid peroxidation and iron accumulation are associated with ricin poisoning. Ferroptosis is an iro...
Source: Toxicology - March 4, 2024 Category: Toxicology Authors: Ruijiao Lin Zijie Jia Hongbing Chen Hongli Xiong Cunhao Bian Xin He Bi Wei Junfeng Fu Minzhu Zhao Jianbo Li Source Type: research
Influence of polystyrene nanoparticles on the toxicity of tetrabromobisphenol A in human intestinal cell lines
Toxicology. 2024 Mar 2:153769. doi: 10.1016/j.tox.2024.153769. Online ahead of print.ABSTRACTResearch and regulatory efforts in toxicology are increasingly focused on the development of suitable non-animal methodologies for human health risk assessment. In this work we used human intestinal Caco-2 and HT29/MTX cell lines to address the potential risks of mixtures of the emerging contaminants tetrabromobisphenol A (TBBPA) and commercial polystyrene nanoparticles (PSNPs). We employed different in vitro settings to evaluate basal cytotoxicity through three complementary endpoints (metabolic activity, plasmatic, and lysosomal ...
Source: Toxicology - March 4, 2024 Category: Toxicology Authors: Patricia Soto-Bielicka Ana Peropadre Soledad Sanz-Alf érez Ma Jos é Hazen Paloma Fern ández Freire Source Type: research
Ferrostatin ‑1 alleviates liver injury via decreasing ferroptosis following ricin toxin poisoning in rat
Toxicology. 2024 Mar 2:153767. doi: 10.1016/j.tox.2024.153767. Online ahead of print.ABSTRACTRicin is a highly toxic plant toxin that can cause multi-organ failure, especially liver dysfunction, and is a potential bioterrorism agent. Despite the serious public health challenge posed by ricin, effective therapeutic for ricin-induced poisoning is currently unavailable. Therefore, it is important to explore the mechanism of ricin poisoning and develop appropriate treatment protocols accordingly. Previous studies have shown that lipid peroxidation and iron accumulation are associated with ricin poisoning. Ferroptosis is an iro...
Source: Toxicology - March 4, 2024 Category: Toxicology Authors: Ruijiao Lin Zijie Jia Hongbing Chen Hongli Xiong Cunhao Bian Xin He Bi Wei Junfeng Fu Minzhu Zhao Jianbo Li Source Type: research
Influence of polystyrene nanoparticles on the toxicity of tetrabromobisphenol A in human intestinal cell lines
Toxicology. 2024 Mar 2:153769. doi: 10.1016/j.tox.2024.153769. Online ahead of print.ABSTRACTResearch and regulatory efforts in toxicology are increasingly focused on the development of suitable non-animal methodologies for human health risk assessment. In this work we used human intestinal Caco-2 and HT29/MTX cell lines to address the potential risks of mixtures of the emerging contaminants tetrabromobisphenol A (TBBPA) and commercial polystyrene nanoparticles (PSNPs). We employed different in vitro settings to evaluate basal cytotoxicity through three complementary endpoints (metabolic activity, plasmatic, and lysosomal ...
Source: Toxicology - March 4, 2024 Category: Toxicology Authors: Patricia Soto-Bielicka Ana Peropadre Soledad Sanz-Alf érez Ma Jos é Hazen Paloma Fern ández Freire Source Type: research
Virtual display of targets: a new level to rise the current understanding of ochratoxin A toxicity from a molecular standpoint
Toxicology. 2024 Mar 1:153765. doi: 10.1016/j.tox.2024.153765. Online ahead of print.ABSTRACTOchratoxin A (OTA) is a worldwide spread mycotoxin contaminating several food and feed commodities, rising concerns for humans and animals. OTA toxicity has been thoroughly assessed over the last 60 years revealing a variety of adverse effects, including nephrotoxicity, hepatotoxicity and possibly carcinogenicity. However, the underpinning mechanisms of action have yet to be completely displayed and understood. In this framework, we applied a virtual pipeline based on molecular docking, dynamics and umbrella simulations to display ...
Source: Toxicology - March 3, 2024 Category: Toxicology Authors: Florinda Perugino Lorenzo Pedroni Gianni Galaverna Chiara Dall'Asta Luca Dellafiora Source Type: research
Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats
Toxicology. 2024 Mar 1:153766. doi: 10.1016/j.tox.2024.153766. Online ahead of print.ABSTRACTBlood transfusion-requiring diseases such as sickle cell anemia and thalassemia are characterized by an imbalance between iron intake and excretion, resulting in an iron overload (IOL) disorder. Hepatotoxicity is prevalent under the IOL disorder because of the associated hepatocellular redox and inflammatory perturbation. The current work was devoted to investigate the potential protection against the IOL-associated hepatotoxicity using chrysin, a naturally-occurring flavone. IOL model was created in male Wistar rats by intraperito...
Source: Toxicology - March 3, 2024 Category: Toxicology Authors: Samyah T Alanazi Samir A Salama Ahmed Magdy El-Ebiary Abdulelah K Altowairqi Atheer T Alharthi Shahad M Alzahrani Shomokh H Althagafi Reema A Alotaibi Ahmed Abd-Eltawab Tammam Source Type: research
Uncovering the toxicity mechanisms of a series of carboxylic acids in liver cells through computational and experimental approaches
This study investigates the toxic behaviour of 24 structurally related carboxylic acids in hepatocytes, specifically their ability to cause accumulation of fatty acids and phospholipids. Using high-content screening (HCS) assays, we identified two distinct lipid accumulation patterns. Subsequently, we developed structure-activity relationship (SAR) and quantitative structure-activity relationship (QSAR) models to determine relevant molecular substructures and descriptors contributing to these adverse effects. Additionally, we calculated physicochemical properties associated with lipid accumulation in hepatocytes and examin...
Source: Toxicology - March 1, 2024 Category: Toxicology Authors: Rita Ortega-Vallbona Rebeca M éndez Laia Tolosa Sylvia E Escher Jos é V Castell Rafael Gozalbes Eva Serrano-Candelas Source Type: research
Uncovering the toxicity mechanisms of a series of carboxylic acids in liver cells through computational and experimental approaches
This study investigates the toxic behaviour of 24 structurally related carboxylic acids in hepatocytes, specifically their ability to cause accumulation of fatty acids and phospholipids. Using high-content screening (HCS) assays, we identified two distinct lipid accumulation patterns. Subsequently, we developed structure-activity relationship (SAR) and quantitative structure-activity relationship (QSAR) models to determine relevant molecular substructures and descriptors contributing to these adverse effects. Additionally, we calculated physicochemical properties associated with lipid accumulation in hepatocytes and examin...
Source: Toxicology - March 1, 2024 Category: Toxicology Authors: Rita Ortega-Vallbona Rebeca M éndez Laia Tolosa Sylvia E Escher Jos é V Castell Rafael Gozalbes Eva Serrano-Candelas Source Type: research
Hazard and Risk Characterization and Grouping of 56 Structurally Diverse PFAS Using a Targeted Battery of Broad Coverage Assays in Six Human Cell Types
Toxicology. 2024 Feb 27:153763. doi: 10.1016/j.tox.2024.153763. Online ahead of print.ABSTRACTPer- and poly-fluoroalkyl substances (PFAS) are extensively used in commerce leading to their prevalence in the environment. Due to their chemical stability, PFAS are considered persistent and bioaccumulative; they are frequently detected in both the environment and humans. Because of this, PFAS as a class (composed of hundreds to thousands of chemicals) are contaminants of very high concern. Little information is available for the vast majority of PFAS, and regulatory agencies lack safety data to determine whether exposure limits...
Source: Toxicology - February 29, 2024 Category: Toxicology Authors: Lucie C Ford Hsing-Chieh Lin Han-Hsuan D Tsai Yi-Hui Zhou Fred A Wright Alexander Sedykh Ruchir R Shah Weihsueh A Chiu Ivan Rusyn Source Type: research
Hazard and Risk Characterization and Grouping of 56 Structurally Diverse PFAS Using a Targeted Battery of Broad Coverage Assays in Six Human Cell Types
Toxicology. 2024 Feb 27:153763. doi: 10.1016/j.tox.2024.153763. Online ahead of print.ABSTRACTPer- and poly-fluoroalkyl substances (PFAS) are extensively used in commerce leading to their prevalence in the environment. Due to their chemical stability, PFAS are considered persistent and bioaccumulative; they are frequently detected in both the environment and humans. Because of this, PFAS as a class (composed of hundreds to thousands of chemicals) are contaminants of very high concern. Little information is available for the vast majority of PFAS, and regulatory agencies lack safety data to determine whether exposure limits...
Source: Toxicology - February 29, 2024 Category: Toxicology Authors: Lucie C Ford Hsing-Chieh Lin Han-Hsuan D Tsai Yi-Hui Zhou Fred A Wright Alexander Sedykh Ruchir R Shah Weihsueh A Chiu Ivan Rusyn Source Type: research
