Secreted cyclophilin A is non-genotoxic but acts as a tumor promoter
Toxicology. 2023 Nov 20:153675. doi: 10.1016/j.tox.2023.153675. Online ahead of print.ABSTRACTChronic inflammation is associated with malignant transformation and creates the microenvironment for tumor progression. Cyclophilin A (CypA) is one of the major pro-inflammatory mediators that accumulates and persists in the site of inflammation in high doses over time. According to multiomics analyses of transformed cells, CypA is widely recognized as a pro-oncogenic factor. Vast experimental data define the functions of intracellular CypA in carcinogenesis, but findings on the role of its secreted form in tumor formation and pr...
Source: Toxicology - November 22, 2023 Category: Toxicology Authors: Anastasiia Kalinina Leila Tilova Kirill Kirsanov Ekaterina Lesovaya Ekaterina Zhidkova Timur Fetisov Galina Ilyinskaya Marianna Yakubovskaya Dmitry Kazansky Ludmila Khromykh Source Type: research
Development of a read-across-derived classification model for the predictions of mutagenicity data and its comparison with traditional QSAR models and expert systems
Toxicology. 2023 Nov 20:153676. doi: 10.1016/j.tox.2023.153676. Online ahead of print.ABSTRACTMutagenicity is considered an important endpoint from the regulatory, environmental and medical points of view. Due to the wide number of compounds that may be of concern and the enormous expenses (in terms of time, money, and animals) associated with rodent mutagenicity bioassays, this endpoint is a major target for the development of alternative approaches for screening and prediction. The majority of old-aged expert systems and quantitative structure-activity relationship (QSAR) models may show reduced performance over time for...
Source: Toxicology - November 22, 2023 Category: Toxicology Authors: Sapna Kumari Pandey Kunal Roy Source Type: research
Nonivamide inhibits proliferation of human corneal epithelial cells by inducing cell cycle arrest and oxidative stress
Toxicology. 2023 Nov 19:153674. doi: 10.1016/j.tox.2023.153674. Online ahead of print.ABSTRACTNonivamide, an agonist of transient receptor potential vanilloid type 1 (TRPV1), is widely used as a riot control agent, police incapacitant spray and pesticide. Although generally considered non-fatal, eye discomfort and even ocular injuries caused by such products are common. Little research has been conducted on the effects of nonivamide on corneal epithelial cells. Cell viability, impedance, flow cytometry, western blotting, and real-time fluorescence analyses were performed to investigate the effects of nonivamide on human co...
Source: Toxicology - November 21, 2023 Category: Toxicology Authors: Haiyun Li Qian Zhang Yi Zhang Sida Zhang Ruihua Zhang Dong Chen Jingjing Shi Jianfu Xu Liqin Li Source Type: research
Nonivamide inhibits proliferation of human corneal epithelial cells by inducing cell cycle arrest and oxidative stress
Toxicology. 2023 Nov 19:153674. doi: 10.1016/j.tox.2023.153674. Online ahead of print.ABSTRACTNonivamide, an agonist of transient receptor potential vanilloid type 1 (TRPV1), is widely used as a riot control agent, police incapacitant spray and pesticide. Although generally considered non-fatal, eye discomfort and even ocular injuries caused by such products are common. Little research has been conducted on the effects of nonivamide on corneal epithelial cells. Cell viability, impedance, flow cytometry, western blotting, and real-time fluorescence analyses were performed to investigate the effects of nonivamide on human co...
Source: Toxicology - November 21, 2023 Category: Toxicology Authors: Haiyun Li Qian Zhang Yi Zhang Sida Zhang Ruihua Zhang Dong Chen Jingjing Shi Jianfu Xu Liqin Li Source Type: research
Increased m6A-RNA Methylation and Demethylase FTO Suppression is Associated with Silica-induced Pulmonary Inflammation and Fibrosis
In conclusion, the high level of global m6A modification in the early stage of silicosis is induced by the downregulation of the demethylase FTO, which may provide a novel target for the diagnosis and treatment of silicosis.PMID:37979906 | DOI:10.1016/j.tox.2023.153673 (Source: Toxicology)
Source: Toxicology - November 18, 2023 Category: Toxicology Authors: Yunyi Xu Liqun Wang Rui Qian Manyu Zhao Xuxi Chen Donglei Sun Ye Wang Weibo Cheng Yiping Chen Qiurong He Yi Dai Yuqin Yao Source Type: research
Increased m6A-RNA Methylation and Demethylase FTO Suppression is Associated with Silica-induced Pulmonary Inflammation and Fibrosis
In conclusion, the high level of global m6A modification in the early stage of silicosis is induced by the downregulation of the demethylase FTO, which may provide a novel target for the diagnosis and treatment of silicosis.PMID:37979906 | DOI:10.1016/j.tox.2023.153673 (Source: Toxicology)
Source: Toxicology - November 18, 2023 Category: Toxicology Authors: Yunyi Xu Liqun Wang Rui Qian Manyu Zhao Xuxi Chen Donglei Sun Ye Wang Weibo Cheng Yiping Chen Qiurong He Yi Dai Yuqin Yao Source Type: research
Arsenic induces metabolome remodeling in mature human adipocytes
Toxicology. 2023 Nov 11:153672. doi: 10.1016/j.tox.2023.153672. Online ahead of print.ABSTRACTHuman lifetime exposure to arsenic through drinking water, food supply or industrial pollution leads to its accumulation in many organs such as liver, kidneys, lungs or pancreas but also adipose tissue. Recently, population-based studies revealed the association between arsenic exposure and the development of metabolic diseases such as obesity and type 2 diabetes. To shed light on the molecular bases of such association, we determined the concentration that inhibited 17% of cell viability and investigated the effects of arsenic ac...
Source: Toxicology - November 13, 2023 Category: Toxicology Authors: Marie Gasser S ébastien Lenglet Nasim Bararpour Tatjana Sajic Julien Vaucher Kim Wiskott Marc Augsburger Tony Fracasso Federica Gilardi Aur élien Thomas Source Type: research
Arsenic induces metabolome remodeling in mature human adipocytes
Toxicology. 2023 Nov 11:153672. doi: 10.1016/j.tox.2023.153672. Online ahead of print.ABSTRACTHuman lifetime exposure to arsenic through drinking water, food supply or industrial pollution leads to its accumulation in many organs such as liver, kidneys, lungs or pancreas but also adipose tissue. Recently, population-based studies revealed the association between arsenic exposure and the development of metabolic diseases such as obesity and type 2 diabetes. To shed light on the molecular bases of such association, we determined the concentration that inhibited 17% of cell viability and investigated the effects of arsenic ac...
Source: Toxicology - November 13, 2023 Category: Toxicology Authors: Marie Gasser S ébastien Lenglet Nasim Bararpour Tatjana Sajic Julien Vaucher Kim Wiskott Marc Augsburger Tony Fracasso Federica Gilardi Aur élien Thomas Source Type: research
Arsenic induces metabolome remodeling in mature human adipocytes
Toxicology. 2023 Nov 11:153672. doi: 10.1016/j.tox.2023.153672. Online ahead of print.ABSTRACTHuman lifetime exposure to arsenic through drinking water, food supply or industrial pollution leads to its accumulation in many organs such as liver, kidneys, lungs or pancreas but also adipose tissue. Recently, population-based studies revealed the association between arsenic exposure and the development of metabolic diseases such as obesity and type 2 diabetes. To shed light on the molecular bases of such association, we determined the concentration that inhibited 17% of cell viability and investigated the effects of arsenic ac...
Source: Toxicology - November 13, 2023 Category: Toxicology Authors: Marie Gasser S ébastien Lenglet Nasim Bararpour Tatjana Sajic Julien Vaucher Kim Wiskott Marc Augsburger Tony Fracasso Federica Gilardi Aur élien Thomas Source Type: research
Arsenic induces metabolome remodeling in mature human adipocytes
Toxicology. 2023 Nov 11:153672. doi: 10.1016/j.tox.2023.153672. Online ahead of print.ABSTRACTHuman lifetime exposure to arsenic through drinking water, food supply or industrial pollution leads to its accumulation in many organs such as liver, kidneys, lungs or pancreas but also adipose tissue. Recently, population-based studies revealed the association between arsenic exposure and the development of metabolic diseases such as obesity and type 2 diabetes. To shed light on the molecular bases of such association, we determined the concentration that inhibited 17% of cell viability and investigated the effects of arsenic ac...
Source: Toxicology - November 13, 2023 Category: Toxicology Authors: Marie Gasser S ébastien Lenglet Nasim Bararpour Tatjana Sajic Julien Vaucher Kim Wiskott Marc Augsburger Tony Fracasso Federica Gilardi Aur élien Thomas Source Type: research
Pesticide Mediated Silent Neurotoxicity and Its Unmasking: An Update on Recent Progress
Toxicology. 2023 Nov 7:153665. doi: 10.1016/j.tox.2023.153665. Online ahead of print.ABSTRACTBeing human's one of the most protected organs, brain is yet most vulnerable to xenobiotics exposure. Though pesticide-mediated neurotoxicity is well-explored, the fraternity of neurotoxicologists is less focused on the phenomenon of "silent" or "clinically undetectable" neurotoxicity. Silent neurotoxicity defines continual trivial changes in the nervous system that do not manifest any overt signs of toxicity unless unmasked by any natural or experimental event. Although this perception is not novel, insufficient experimental and e...
Source: Toxicology - November 9, 2023 Category: Toxicology Authors: Ankita Srivastava Ankur Kumar Srivastava Abhishek Pandeya Aditya Bhushan Pant Source Type: research
Pesticide Mediated Silent Neurotoxicity and Its Unmasking: An Update on Recent Progress
Toxicology. 2023 Nov 7:153665. doi: 10.1016/j.tox.2023.153665. Online ahead of print.ABSTRACTBeing human's one of the most protected organs, brain is yet most vulnerable to xenobiotics exposure. Though pesticide-mediated neurotoxicity is well-explored, the fraternity of neurotoxicologists is less focused on the phenomenon of "silent" or "clinically undetectable" neurotoxicity. Silent neurotoxicity defines continual trivial changes in the nervous system that do not manifest any overt signs of toxicity unless unmasked by any natural or experimental event. Although this perception is not novel, insufficient experimental and e...
Source: Toxicology - November 9, 2023 Category: Toxicology Authors: Ankita Srivastava Ankur Kumar Srivastava Abhishek Pandeya Aditya Bhushan Pant Source Type: research
Pesticide Mediated Silent Neurotoxicity and Its Unmasking: An Update on Recent Progress
Toxicology. 2023 Nov 7:153665. doi: 10.1016/j.tox.2023.153665. Online ahead of print.ABSTRACTBeing human's one of the most protected organs, brain is yet most vulnerable to xenobiotics exposure. Though pesticide-mediated neurotoxicity is well-explored, the fraternity of neurotoxicologists is less focused on the phenomenon of "silent" or "clinically undetectable" neurotoxicity. Silent neurotoxicity defines continual trivial changes in the nervous system that do not manifest any overt signs of toxicity unless unmasked by any natural or experimental event. Although this perception is not novel, insufficient experimental and e...
Source: Toxicology - November 9, 2023 Category: Toxicology Authors: Ankita Srivastava Ankur Kumar Srivastava Abhishek Pandeya Aditya Bhushan Pant Source Type: research
Pesticide Mediated Silent Neurotoxicity and Its Unmasking: An Update on Recent Progress
Toxicology. 2023 Nov 7:153665. doi: 10.1016/j.tox.2023.153665. Online ahead of print.ABSTRACTBeing human's one of the most protected organs, brain is yet most vulnerable to xenobiotics exposure. Though pesticide-mediated neurotoxicity is well-explored, the fraternity of neurotoxicologists is less focused on the phenomenon of "silent" or "clinically undetectable" neurotoxicity. Silent neurotoxicity defines continual trivial changes in the nervous system that do not manifest any overt signs of toxicity unless unmasked by any natural or experimental event. Although this perception is not novel, insufficient experimental and e...
Source: Toxicology - November 9, 2023 Category: Toxicology Authors: Ankita Srivastava Ankur Kumar Srivastava Abhishek Pandeya Aditya Bhushan Pant Source Type: research
In Vitro Binding Analysis of Legacy-Linear and New Generation-Cyclic Perfluoro-Alkyl Substances on Sex Hormone Binding Globulin and Albumin, Suggests Low Impact on Serum Hormone Kinetics of Testosterone
Toxicology. 2023 Nov 4:153664. doi: 10.1016/j.tox.2023.153664. Online ahead of print.ABSTRACTIn humans, serum testosterone (T) is largely bound to the sex hormone binding globulin (SHBG) and human serum albumin (hSA), resulting in a 2-3% of unbound or "free" active quote (FT). Endocrine-disrupting chemicals, including perfluoro-alkyl substances (PFAS), are recognized to interfere with the hormonal axes, but the possible impact on the FT quote has not been addressed so far. Here we investigated the possible competition of two acknowledged PFAS molecules on T binding to SHBG and hSA. In particular, perfluoro-octanoic acid (P...
Source: Toxicology - November 6, 2023 Category: Toxicology Authors: Angela Pavan Laura Cendron Andrea Di Nisio Federica Pedrucci Iva Sabovic Alessandro Scarso Alberto Ferlin Alessandro Angelini Carlo Foresta Luca De Toni Source Type: research
