DON induced DNA damage triggers absence of p53-mediated G2 arrest and apoptosis in IPEC-1 cells
In this study, we explored the detrimental impacts of DON on porcine intestinal epithelial cells (IPEC-1), serving as a representative model for porcine intestinal epithelial cells. After treating cells with DON for 24hours, DON can significantly inhibit the activity of cells, induce the production of reactive oxygen species (ROS), significantly reduce the content of glutathione and the activity of catalase, and increase the activity of superoxide dismutase and malondialdehyde, leading to an imbalance in intracellular redox status. In addition, DON can induce DNA double-strand breaks, and decrease mitochondrial membrane po...
Source: Toxicology - December 17, 2023 Category: Toxicology Authors: Silu Hou Jingjiao Ma Yuqiang Cheng Zhaofei Wang Guiping Wang Aiqing Jia Hengan Wang Jianhe Sun Yaxian Yan Source Type: research
A Deep-Learning Approach for Identifying Prospective Chemical Hazards
Toxicology. 2023 Dec 15:153708. doi: 10.1016/j.tox.2023.153708. Online ahead of print.ABSTRACTWith the aim of helping to set safe exposure limits for the general population, various techniques have been implemented to conduct risk assessments for chemicals and other environmental stressors; however, none of these tools facilitate the identification of completely new chemicals that are likely hazardous and elicit an adverse biological effect. Here, we detail a novel in silico, deep-learning framework that is designed to systematically generate structures for new chemical compounds that are predicted to be chemical hazards. ...
Source: Toxicology - December 17, 2023 Category: Toxicology Authors: Sohaib Habiballah Lenwood S Heath Brad Reisfeld Source Type: research
Caspases downregulate nickel and hydrogen peroxide-induced IL-8 production via modification of c-Jun N-terminal kinases
This study highlighted the significance of apoptosis in inflammatory diseases, including Ni-induced dermatitis.PMID:38104653 | DOI:10.1016/j.tox.2023.153710 (Source: Toxicology)
Source: Toxicology - December 17, 2023 Category: Toxicology Authors: Ryusei Maeyama Ryosuke Segawa Ryo Onodera Masahiro Hiratsuka Noriyasu Hirasawa Source Type: research
DON induced DNA damage triggers absence of p53-mediated G2 arrest and apoptosis in IPEC-1 cells
In this study, we explored the detrimental impacts of DON on porcine intestinal epithelial cells (IPEC-1), serving as a representative model for porcine intestinal epithelial cells. After treating cells with DON for 24hours, DON can significantly inhibit the activity of cells, induce the production of reactive oxygen species (ROS), significantly reduce the content of glutathione and the activity of catalase, and increase the activity of superoxide dismutase and malondialdehyde, leading to an imbalance in intracellular redox status. In addition, DON can induce DNA double-strand breaks, and decrease mitochondrial membrane po...
Source: Toxicology - December 17, 2023 Category: Toxicology Authors: Silu Hou Jingjiao Ma Yuqiang Cheng Zhaofei Wang Guiping Wang Aiqing Jia Hengan Wang Jianhe Sun Yaxian Yan Source Type: research
A Deep-Learning Approach for Identifying Prospective Chemical Hazards
Toxicology. 2023 Dec 15:153708. doi: 10.1016/j.tox.2023.153708. Online ahead of print.ABSTRACTWith the aim of helping to set safe exposure limits for the general population, various techniques have been implemented to conduct risk assessments for chemicals and other environmental stressors; however, none of these tools facilitate the identification of completely new chemicals that are likely hazardous and elicit an adverse biological effect. Here, we detail a novel in silico, deep-learning framework that is designed to systematically generate structures for new chemical compounds that are predicted to be chemical hazards. ...
Source: Toxicology - December 17, 2023 Category: Toxicology Authors: Sohaib Habiballah Lenwood S Heath Brad Reisfeld Source Type: research
Redox imbalance and inflammation: A link to depression risk in brazilian pesticide-exposed farmers
This study aims to elucidate the mechanisms linking occupational pesticide exposure to depression among rural workers from Maravilha, Brazil. We assessed the mental health, oxidative, and inflammatory profiles of farmers exposed to pesticides (N = 28) and compared them to an urban control group without occupational exposure to pesticides (N = 25). Data on sociodemographic, occupational history, and clinical records were collected. Emotional states were evaluated using the State-Trait Anxiety Inventory (STAI) and Beck Depression Inventory (BDI). Biochemical, hematological, inflammatory, and redox parameters were examined in...
Source: Toxicology - December 14, 2023 Category: Toxicology Authors: Mariane Magalh ães Zanchi Filomena Marafon Katiuska Marins Margarete Dulce Bagatini Ariane Zamoner Source Type: research
Redox imbalance and inflammation: A link to depression risk in brazilian pesticide-exposed farmers
This study aims to elucidate the mechanisms linking occupational pesticide exposure to depression among rural workers from Maravilha, Brazil. We assessed the mental health, oxidative, and inflammatory profiles of farmers exposed to pesticides (N = 28) and compared them to an urban control group without occupational exposure to pesticides (N = 25). Data on sociodemographic, occupational history, and clinical records were collected. Emotional states were evaluated using the State-Trait Anxiety Inventory (STAI) and Beck Depression Inventory (BDI). Biochemical, hematological, inflammatory, and redox parameters were examined in...
Source: Toxicology - December 14, 2023 Category: Toxicology Authors: Mariane Magalh ães Zanchi Filomena Marafon Katiuska Marins Margarete Dulce Bagatini Ariane Zamoner Source Type: research
Redox Imbalance and Inflammation: A Link to Depression Risk in Brazilian pesticide-exposed Farmers
This study aims to elucidate the mechanisms linking occupational pesticide exposure to depression among rural workers from Maravilha, Brazil. We assessed the mental health, oxidative, and inflammatory profiles of farmers exposed to pesticides (N=28) and compared them to an urban control group without occupational exposure to pesticides (N=25). Data on sociodemographic, occupational history, and clinical records were collected. Emotional states were evaluated using the State-Trait Anxiety Inventory (STAI) and Beck Depression Inventory (BDI). Biochemical, hematological, inflammatory, and redox parameters were examined in blo...
Source: Toxicology - December 14, 2023 Category: Toxicology Authors: Mariane Magalh ães Zanchi Filomena Marafon Katiuska Marins Margarete Dulce Bagatini Ariane Zamoner Source Type: research
Exposure to volatile organic compounds induces cardiovascular toxicity that may involve DNA methylation
In this study, we aimed to investigate the effects of a mixture of six VOCs on cardiovascular development in zebrafish embryos. Embryos were exposed to different concentrations of VOCs mixture (32mg/L, 64mg/L and 128mg/L) for 96hours, cardiovascular abnormalities including elongated heart shape, increased distance between sinus venosus and bulbus arteriosus, slowed circulation and altered heart rate were observed in a dose- and time-dependent manner. Meanwhile, VOCs exposure increased global DNA methylation levels in embryos. Analysis identified hundreds of differentially methylated sites and the enrichment of differential...
Source: Toxicology - December 9, 2023 Category: Toxicology Authors: Zhuoyan Li Jieru Lu Xuehua Ruan Yurong Wu Jianyuan Zhao Xianting Jiao Jing Sun Kun Sun Source Type: research
Exposure to volatile organic compounds induces cardiovascular toxicity that may involve DNA methylation
In this study, we aimed to investigate the effects of a mixture of six VOCs on cardiovascular development in zebrafish embryos. Embryos were exposed to different concentrations of VOCs mixture (32mg/L, 64mg/L and 128mg/L) for 96hours, cardiovascular abnormalities including elongated heart shape, increased distance between sinus venosus and bulbus arteriosus, slowed circulation and altered heart rate were observed in a dose- and time-dependent manner. Meanwhile, VOCs exposure increased global DNA methylation levels in embryos. Analysis identified hundreds of differentially methylated sites and the enrichment of differential...
Source: Toxicology - December 9, 2023 Category: Toxicology Authors: Zhuoyan Li Jieru Lu Xuehua Ruan Yurong Wu Jianyuan Zhao Xianting Jiao Jing Sun Kun Sun Source Type: research
Exposure to volatile organic compounds induces cardiovascular toxicity that may involve DNA methylation
In this study, we aimed to investigate the effects of a mixture of six VOCs on cardiovascular development in zebrafish embryos. Embryos were exposed to different concentrations of VOCs mixture (32mg/L, 64mg/L and 128mg/L) for 96hours, cardiovascular abnormalities including elongated heart shape, increased distance between sinus venosus and bulbus arteriosus, slowed circulation and altered heart rate were observed in a dose- and time-dependent manner. Meanwhile, VOCs exposure increased global DNA methylation levels in embryos. Analysis identified hundreds of differentially methylated sites and the enrichment of differential...
Source: Toxicology - December 9, 2023 Category: Toxicology Authors: Zhuoyan Li Jieru Lu Xuehua Ruan Yurong Wu Jianyuan Zhao Xianting Jiao Jing Sun Kun Sun Source Type: research
Exposure to volatile organic compounds induces cardiovascular toxicity that may involve DNA methylation
In this study, we aimed to investigate the effects of a mixture of six VOCs on cardiovascular development in zebrafish embryos. Embryos were exposed to different concentrations of VOCs mixture (32mg/L, 64mg/L and 128mg/L) for 96hours, cardiovascular abnormalities including elongated heart shape, increased distance between sinus venosus and bulbus arteriosus, slowed circulation and altered heart rate were observed in a dose- and time-dependent manner. Meanwhile, VOCs exposure increased global DNA methylation levels in embryos. Analysis identified hundreds of differentially methylated sites and the enrichment of differential...
Source: Toxicology - December 9, 2023 Category: Toxicology Authors: Zhuoyan Li Jieru Lu Xuehua Ruan Yurong Wu Jianyuan Zhao Xianting Jiao Jing Sun Kun Sun Source Type: research
Dibromoacetonitrile induced autophagy by mediating the PERK signalling pathway and ROS interaction in HT22 cell
This study indicated that DBAN (10μM, 24h) activated the ERS protein kinase like endoplasmic reticulum kinase (PERK) signaling pathway. The ERS inhibitor 4-phenylbutyric acid (4-PBA) reversed DBAN-inhibited cell viability and alleviated DBAN-induced apoptosis in HT22 cell, indicating that activation of the ERS PERK pathway mediates DBAN induced cytotoxicity. Moreover, DBAN activated autophagy. The autophagy inhibitor 3-methyladenine(3-MA) reversed DBAN-inhibited cell viability and alleviated DBAN-induced apoptosis in HT22 cell, suggesting that autophagy activation mediates DBAN-induced cell toxicity. Notably, the results ...
Source: Toxicology - December 8, 2023 Category: Toxicology Authors: Fang Li Xueyu Zhu Xinwei Xu Jie Zhou Rongzhu Lu Suhua Wang Guangwei Xing Yang Ye Source Type: research
Dibromoacetonitrile induced autophagy by mediating the PERK signalling pathway and ROS interaction in HT22 cell
This study indicated that DBAN (10μM, 24h) activated the ERS protein kinase like endoplasmic reticulum kinase (PERK) signaling pathway. The ERS inhibitor 4-phenylbutyric acid (4-PBA) reversed DBAN-inhibited cell viability and alleviated DBAN-induced apoptosis in HT22 cell, indicating that activation of the ERS PERK pathway mediates DBAN induced cytotoxicity. Moreover, DBAN activated autophagy. The autophagy inhibitor 3-methyladenine(3-MA) reversed DBAN-inhibited cell viability and alleviated DBAN-induced apoptosis in HT22 cell, suggesting that autophagy activation mediates DBAN-induced cell toxicity. Notably, the results ...
Source: Toxicology - December 8, 2023 Category: Toxicology Authors: Fang Li Xueyu Zhu Xinwei Xu Jie Zhou Rongzhu Lu Suhua Wang Guangwei Xing Yang Ye Source Type: research
ATR induces hepatic lipid metabolism disorder in rats by activating IRE1 α/XBP1 signaling pathway
This study can provide valuable insights as a reference for the prevention and control of hazards associated with agricultural residues.PMID:38056589 | DOI:10.1016/j.tox.2023.153696 (Source: Toxicology)
Source: Toxicology - December 6, 2023 Category: Toxicology Authors: Honghao Qian Yaming Zhao Yiming Wang Haotang Zhao Jianwei Cui Ziyu Wang Hui Ye Xiaoqi Fang Zhili Ge Yuezhu Zhang Lin Ye Source Type: research
