Distinct bile acid alterations in response to a single administration of PFOA and PFDA in mice
Toxicology. 2024 Jan 3:153719. doi: 10.1016/j.tox.2023.153719. Online ahead of print.ABSTRACTPer- and polyfluoroalkyl substances (PFASs), a group of synthetic chemicals that were once widely used for industrial purposes and in consumer products, are widely found in the environment and in human blood due to their extraordinary resistance to degradation. Once inside the body, PFASs can activate nuclear receptors such as PPARĪ± and CAR. The present study aimed to investigate the impact of perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) on liver structure and functions, as well as bile acid homeostasis in mice....
Source: Toxicology - January 5, 2024 Category: Toxicology Authors: Xiaoxiao Yu Youcai Zhang Bruno Cogliati Curtis D Klaassen Sanaya Kumar Xingguo Cheng Pengli Bu Source Type: research
Distinct bile acid alterations in response to a single administration of PFOA and PFDA in mice
Toxicology. 2024 Jan 3:153719. doi: 10.1016/j.tox.2023.153719. Online ahead of print.ABSTRACTPer- and polyfluoroalkyl substances (PFASs), a group of synthetic chemicals that were once widely used for industrial purposes and in consumer products, are widely found in the environment and in human blood due to their extraordinary resistance to degradation. Once inside the body, PFASs can activate nuclear receptors such as PPARĪ± and CAR. The present study aimed to investigate the impact of perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) on liver structure and functions, as well as bile acid homeostasis in mice....
Source: Toxicology - January 5, 2024 Category: Toxicology Authors: Xiaoxiao Yu Youcai Zhang Bruno Cogliati Curtis D Klaassen Sanaya Kumar Xingguo Cheng Pengli Bu Source Type: research
Chronic Pb exposure impairs learning and memory abilities by inhibiting excitatory projection neuro-circuit of the hippocampus in mice
In conclusion, our data indicated that Pb significantly impaired the excitatory connections from EC to the hippocampus (CA1 and DG), providing a novel neuro-circuitry basis for Pb neurotoxicity.PMID:38160928 | DOI:10.1016/j.tox.2023.153717 (Source: Toxicology)
Source: Toxicology - December 31, 2023 Category: Toxicology Authors: Rong-Xin Zou Xiaozhen Gu Chenqing Huang Hui-Li Wang Xiang-Tao Chen Source Type: research
Neurodevelopment effects of early life bisphenol-A exposure on visual memory: insights into recovery dynamics
Toxicology. 2023 Dec 29:153718. doi: 10.1016/j.tox.2023.153718. Online ahead of print.ABSTRACTBisphenol A (BPA), a ubiquitous endocrine disruptor, is implicated in the cognitive deficits observed in both children and animals. Especially, BPA-induced spatial memory deterioration during the whole development phase of rodents has been well delineated. However, whether BPA exposure on the different development phases exerts similar effects on the prefrontal cortex (PFC) dependent visual memory is still elusive. Here, we chose two exposure windows, the whole gestation and lactation phases (E0~P21) and the whole juvenile and ado...
Source: Toxicology - December 31, 2023 Category: Toxicology Authors: Wentai Zhang Linke Zhang Weifeng Liang Huan Wang Fan Hu Source Type: research
Chronic Pb exposure impairs learning and memory abilities by inhibiting excitatory projection neuro-circuit of the hippocampus in mice
In conclusion, our data indicated that Pb significantly impaired the excitatory connections from EC to the hippocampus (CA1 and DG), providing a novel neuro-circuitry basis for Pb neurotoxicity.PMID:38160928 | DOI:10.1016/j.tox.2023.153717 (Source: Toxicology)
Source: Toxicology - December 31, 2023 Category: Toxicology Authors: Rong-Xin Zou Xiaozhen Gu Chenqing Huang Hui-Li Wang Xiang-Tao Chen Source Type: research
Neurodevelopment effects of early life bisphenol-A exposure on visual memory: insights into recovery dynamics
Toxicology. 2023 Dec 29:153718. doi: 10.1016/j.tox.2023.153718. Online ahead of print.ABSTRACTBisphenol A (BPA), a ubiquitous endocrine disruptor, is implicated in the cognitive deficits observed in both children and animals. Especially, BPA-induced spatial memory deterioration during the whole development phase of rodents has been well delineated. However, whether BPA exposure on the different development phases exerts similar effects on the prefrontal cortex (PFC) dependent visual memory is still elusive. Here, we chose two exposure windows, the whole gestation and lactation phases (E0~P21) and the whole juvenile and ado...
Source: Toxicology - December 31, 2023 Category: Toxicology Authors: Wentai Zhang Linke Zhang Weifeng Liang Huan Wang Fan Hu Source Type: research
Chronic Pb exposure impairs learning and memory abilities by inhibiting excitatory projection neuro-circuit of the hippocampus in mice
In conclusion, our data indicated that Pb significantly impaired the excitatory connections from EC to the hippocampus (CA1 and DG), providing a novel neuro-circuitry basis for Pb neurotoxicity.PMID:38160928 | DOI:10.1016/j.tox.2023.153717 (Source: Toxicology)
Source: Toxicology - December 31, 2023 Category: Toxicology Authors: Rong-Xin Zou Xiaozhen Gu Chenqing Huang Hui-Li Wang Xiang-Tao Chen Source Type: research
Neurodevelopment effects of early life bisphenol-A exposure on visual memory: insights into recovery dynamics
Toxicology. 2023 Dec 29:153718. doi: 10.1016/j.tox.2023.153718. Online ahead of print.ABSTRACTBisphenol A (BPA), a ubiquitous endocrine disruptor, is implicated in the cognitive deficits observed in both children and animals. Especially, BPA-induced spatial memory deterioration during the whole development phase of rodents has been well delineated. However, whether BPA exposure on the different development phases exerts similar effects on the prefrontal cortex (PFC) dependent visual memory is still elusive. Here, we chose two exposure windows, the whole gestation and lactation phases (E0~P21) and the whole juvenile and ado...
Source: Toxicology - December 31, 2023 Category: Toxicology Authors: Wentai Zhang Linke Zhang Weifeng Liang Huan Wang Fan Hu Source Type: research
Chronic Pb exposure impairs learning and memory abilities by inhibiting excitatory projection neuro-circuit of the hippocampus in mice
In conclusion, our data indicated that Pb significantly impaired the excitatory connections from EC to the hippocampus (CA1 and DG), providing a novel neuro-circuitry basis for Pb neurotoxicity.PMID:38160928 | DOI:10.1016/j.tox.2023.153717 (Source: Toxicology)
Source: Toxicology - December 31, 2023 Category: Toxicology Authors: Rong-Xin Zou Xiaozhen Gu Chenqing Huang Hui-Li Wang Xiang-Tao Chen Source Type: research
Neurodevelopment effects of early life bisphenol-A exposure on visual memory: insights into recovery dynamics
Toxicology. 2023 Dec 29:153718. doi: 10.1016/j.tox.2023.153718. Online ahead of print.ABSTRACTBisphenol A (BPA), a ubiquitous endocrine disruptor, is implicated in the cognitive deficits observed in both children and animals. Especially, BPA-induced spatial memory deterioration during the whole development phase of rodents has been well delineated. However, whether BPA exposure on the different development phases exerts similar effects on the prefrontal cortex (PFC) dependent visual memory is still elusive. Here, we chose two exposure windows, the whole gestation and lactation phases (E0~P21) and the whole juvenile and ado...
Source: Toxicology - December 31, 2023 Category: Toxicology Authors: Wentai Zhang Linke Zhang Weifeng Liang Huan Wang Fan Hu Source Type: research
Molecular docking study of frequently used food additives for selected targets depending on the chromosomal abnormalities they cause
In this study, we determined the interactions of these food additives with ATM and p53 proteins, which are activated in the cell due to genotoxic effects, and with DNA by employing the molecular docking method for the first time. Among the food additives, SB (-4,307) for ATM, XYL (-4,629) for p53, and XYL (-4,927) for DNA showed the highest affinity. Therefore, flexible docking (IFD) scores were determined for SB, XYL, and MDG from flavor enhancers. The potential binding modes of the food additives to target molecules' possible inhibition mechanisms were determined by molecular docking. Thus, new information was obtained t...
Source: Toxicology - December 30, 2023 Category: Toxicology Authors: Fatma Okus Deniz Yuzbasioglu Fatma Unal Source Type: research
Assessment of no-observed-effect-levels for DNA adducts formation by genotoxic carcinogens in fetal turkey livers
Toxicology. 2023 Dec 22;501:153714. doi: 10.1016/j.tox.2023.153714. Online ahead of print.ABSTRACTFor genotoxic carcinogens, covalent binding to DNA is a critical initiating event in tumorigenesis. The present research investigated dose-effect relationships of three genotoxic carcinogens representing different structural classes, 2-acetylaminofluorene (2-AAF), benzo[a]pyrene (B[a]P) and quinoline (QUI), to assess the existence of no-observed-effect-levels (NOELs) for the formation of DNA adducts. Carcinogens were administered into the air sac of fertilized turkey eggs over wide dose ranges in three daily injections on days...
Source: Toxicology - December 23, 2023 Category: Toxicology Authors: Tetyana Kobets Christina Hickey George Johnson Jian-Dong Duan Sylvain Etter Benjamin Smith Gary M Williams Source Type: research
Assessment of no-observed-effect-levels for DNA adducts formation by genotoxic carcinogens in fetal turkey livers
Toxicology. 2023 Dec 22;501:153714. doi: 10.1016/j.tox.2023.153714. Online ahead of print.ABSTRACTFor genotoxic carcinogens, covalent binding to DNA is a critical initiating event in tumorigenesis. The present research investigated dose-effect relationships of three genotoxic carcinogens representing different structural classes, 2-acetylaminofluorene (2-AAF), benzo[a]pyrene (B[a]P) and quinoline (QUI), to assess the existence of no-observed-effect-levels (NOELs) for the formation of DNA adducts. Carcinogens were administered into the air sac of fertilized turkey eggs over wide dose ranges in three daily injections on days...
Source: Toxicology - December 23, 2023 Category: Toxicology Authors: Tetyana Kobets Christina Hickey George Johnson Jian-Dong Duan Sylvain Etter Benjamin Smith Gary M Williams Source Type: research
Assessment of no-observed-effect-levels for DNA adducts formation by genotoxic carcinogens in fetal turkey livers
Toxicology. 2023 Dec 22;501:153714. doi: 10.1016/j.tox.2023.153714. Online ahead of print.ABSTRACTFor genotoxic carcinogens, covalent binding to DNA is a critical initiating event in tumorigenesis. The present research investigated dose-effect relationships of three genotoxic carcinogens representing different structural classes, 2-acetylaminofluorene (2-AAF), benzo[a]pyrene (B[a]P) and quinoline (QUI), to assess the existence of no-observed-effect-levels (NOELs) for the formation of DNA adducts. Carcinogens were administered into the air sac of fertilized turkey eggs over wide dose ranges in three daily injections on days...
Source: Toxicology - December 23, 2023 Category: Toxicology Authors: Tetyana Kobets Christina Hickey George Johnson Jian-Dong Duan Sylvain Etter Benjamin Smith Gary M Williams Source Type: research
Assessment of no-observed-effect-levels for DNA adducts formation by genotoxic carcinogens in fetal turkey livers
Toxicology. 2023 Dec 22;501:153714. doi: 10.1016/j.tox.2023.153714. Online ahead of print.ABSTRACTFor genotoxic carcinogens, covalent binding to DNA is a critical initiating event in tumorigenesis. The present research investigated dose-effect relationships of three genotoxic carcinogens representing different structural classes, 2-acetylaminofluorene (2-AAF), benzo[a]pyrene (B[a]P) and quinoline (QUI), to assess the existence of no-observed-effect-levels (NOELs) for the formation of DNA adducts. Carcinogens were administered into the air sac of fertilized turkey eggs over wide dose ranges in three daily injections on days...
Source: Toxicology - December 23, 2023 Category: Toxicology Authors: Tetyana Kobets Christina Hickey George Johnson Jian-Dong Duan Sylvain Etter Benjamin Smith Gary M Williams Source Type: research
