A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis

In conclusion, our study delivers a generic methodology for developing and assessing AOP networks. The quantitative WoE scoring method facilitates in determining the level of support for KERs within the optimized AOP network, offering valuable insights into its utility in both scientific research and regulatory contexts. KERs supported by robust evidence represent promising candidates for inclusion in an in vitro test battery for reliably predicting chemical-induced liver steatosis within regulatory frameworks.PMID:38677583 | DOI:10.1016/j.tox.2024.153814

Source: Toxicology - April 27, 2024 Category: Toxicology Authors: Anouk Verhoeven Jonas van Ertvelde Joost Boeckmans Alexandra Gatzios Ramiro Jover Birgitte Lindeman Graciela Lopez-Soop Robim M Rodrigues Anna Rapisarda Julen Sanz-Serrano Marth Stinckens Sara Sepehri Marc Teunis Mathieu Vinken Jian Jiang Tamara Vanhaecke Source Type: research