REPLY: Use of anticoagulation in patients with breast cancer and atrial fibrillation.
ators PMID: 31570254 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - September 24, 2019 Category: Cancer & Oncology Authors: Pardo Sanz A, Rincón LM, Zamorano JL, Antithrombotic Management of patients with Breast cancER and Atrial Fibrillation multicenter registry (AMBER-AF) investigators Tags: Breast Source Type: research

A systematic review and meta-analysis of clinician-reported versus patient-reported outcomes of radiation dermatitis.
Abstract Radiation dermatitis is a common adverse effect of radiotherapy (RT) in breast cancer patients. Although radiation dermatitis is reported by either the clinician or the patient, previous studies have shown disagreement between clinician-reported outcomes (CROs) and patient-reported outcomes (PROs). This review evaluated the extent of discordance between CROs and PROs for radiation dermatitis. Studies reporting both clinician and patient-reported outcomes for external beam RT were eligible. Nine studies met the inclusion criteria for the systematic review, while 8 of these studies were eligible for inclusi...
Source: Breast - September 19, 2019 Category: Cancer & Oncology Authors: Lam E, Yee C, Wong G, Popovic M, Drost L, Pon K, Vesprini D, Lam H, Aljabri S, Soliman H, DeAngelis C, Chow E Tags: Breast Source Type: research

Corrigendum to "Secondary breast angiosarcoma: A multicentre retrospective survey by the national Italian association of breast surgeons (ANISC)" [Breast 2019 56-60].
Corrigendum to "Secondary breast angiosarcoma: A multicentre retrospective survey by the national Italian association of breast surgeons (ANISC)" [Breast 2019 56-60]. Breast. 2019 Sep 19;: Authors: Taffurelli M, Pellegrini A, Meattini I, Orzalesi L, Tinterri C, Roncella M, Terribile D, Caruso F, Tazzioli G, Pollini G, Friedman D, Mariotti C, Cianchetti E, Cabula C, Thomas R, Cedolini C, Rovera F, Grassi M, Lucani G, Cappella A, Bortul M, Stacul G, Scarabeo F, Procaccini E, Galimberti V PMID: 31543291 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - September 19, 2019 Category: Cancer & Oncology Authors: Taffurelli M, Pellegrini A, Meattini I, Orzalesi L, Tinterri C, Roncella M, Terribile D, Caruso F, Tazzioli G, Pollini G, Friedman D, Mariotti C, Cianchetti E, Cabula C, Thomas R, Cedolini C, Rovera F, Grassi M, Lucani G, Cappella A, Bortul M, Stacul G, S Tags: Breast Source Type: research

Occupational exposures and male breast cancer: A nested case-control study in the Nordic countries.
Abstract BACKGROUND: Male breast cancer (MBC) is a rare and understudied disease. There is limited evidence on association between environmental and occupational agents and MBC. Some similarities in risk factors may be shared with female breast cancer. We evaluated solvents, metals, exhaust gases and other agents in relation to MBC within the large Nordic Occupational Cancer Study (NOCCA). METHODS: The study included 1469 MBC cases and 7345 controls from Finland, Iceland and Sweden, matched for the date of birth, sex and country. Cases were identified through national cancer registries. Data on occupation and...
Source: Breast - September 12, 2019 Category: Cancer & Oncology Authors: Talibov M, Hansen J, Heikkinen S, Martinsen JI, Sparen P, Tryggvadottir L, Weiderpass E, Pukkala E Tags: Breast Source Type: research

Transforming Breast Cancer Together: European elections manifesto 2019 seizing the opportunities for breast cancer patients.
Abstract With the European Parliament elections having taken place in May 2019 and a new European Commission (EC) taking office in November 2019, this year is critical for European policymakers, as goals and priorities of the European Union (EU) for the next five years will be discussed and agreed upon. This Manifesto issued by the Transforming Breast Cancer Together initiative calls upon policymakers to improve services for patients in an area still of high unmet need and reduce the societal impact of breast cancer by elevating it as a health policy priority to improve breast cancer prevention, diagnosis and care...
Source: Breast - September 7, 2019 Category: Cancer & Oncology Authors: Cardoso F, Bușoi CS, Cattaneo I, Decise D, Cardone A, Filicevas A, Gentile E, Wierinck L, Knox S, Sebastiani S, Terrasanta C, Ujupan S, Ventura R, Wilson B, Rubio IT Tags: Breast Source Type: research

Implementing the hub and spoke model for the oncofertility units.
PMID: 31515107 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - September 4, 2019 Category: Cancer & Oncology Authors: Razeti MG, Spinaci S, Lambertini M Tags: Breast Source Type: research

Self-reported work ability in breast cancer survivors; a prospective cohort study in the Netherlands.
Abstract PURPOSE: To evaluate patient-reported work ability of breast cancer patients, to compare scores with the Dutch general population, and to identify determinants of reduced work ability in breast cancer patients. METHODS: In a prospective cohort study, we identified 939 patients
Source: Breast - August 28, 2019 Category: Cancer & Oncology Authors: Gregorowitsch ML, van den Bongard HJGD, Couwenberg AM, Young-Afat DA, Haaring C, Van Dalen T, Schoenmaeckers EJP, Agterof MJ, Baas IO, Sier MF, Ernst MF, van Hummel R, Verkooijen HM, UMBRELLA study group Tags: Breast Source Type: research

A phase II randomized clinical trial of the effect of metformin versus placebo on progression-free survival in women with metastatic breast cancer receiving standard chemotherapy.
CONCLUSION: In this population metformin showed no significant effect on RR, PFS or OS. These results do not support the use of metformin with chemotherapy in non-diabetic MBC patients. PMID: 31472446 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - August 22, 2019 Category: Cancer & Oncology Authors: Pimentel I, Lohmann AE, Ennis M, Dowling RJO, Cescon D, Elser C, Potvin KR, Haq R, Hamm C, Chang MC, Stambolic V, Goodwin PJ Tags: Breast Source Type: research

Metronomic chemotherapy for advanced breast cancer patients in the real world practice: Final results of the VICTOR-6 study.
i L, Giovanardi F, Grassadonia A, Leonardi V, Marchetti P, Melegari E, Musolino A, Nicolini M, Putzu C, Riccardi F, Santini D, Saracchini S, Sarobba MG, Schintu MG, Scognamiglio G, Spadaro P, Taverniti C, Toniolo D, Tralongo P, Turletti A, Valenza R, Valerio MR, Vici P, Clivio L, Torri V, VICTOR Study Group Abstract Metronomic chemotherapy (mCHT) refers to the minimum biologically effective dose of a chemotherapy agent given as a continuous dosing regimen, with no prolonged drug-free breaks, that leads to antitumor activity. Aim of the present study is to describe the use of mCHT in a retrospective cohort of metas...
Source: Breast - August 22, 2019 Category: Cancer & Oncology Authors: Cazzaniga ME, Pinotti G, Montagna E, Amoroso D, Berardi R, Butera A, Cagossi K, Cavanna L, Ciccarese M, Cinieri S, Cretella E, De Conciliis E, Febbraro A, Ferraù F, Ferzi A, Fiorentini G, Fontana A, Gambaro AR, Garrone O, Gebbia V, Generali D, Gianni L, Tags: Breast Source Type: research

Lymph node infiltration, parallel metastasis and treatment success in breast cancer.
CONCLUSION: The number of pLNs is an epiphenomenon of the onset and chronometer for the duration of TCs disseminating from growing BCs. METs are initiated parallel to LNs by PTs and not caused by pLNs. This LN process without cascade-like MET initiation should be generalizable to all common solid tumors. PMID: 31415842 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - August 5, 2019 Category: Cancer & Oncology Authors: Engel J, Weichert W, Jung A, Emeny R, Hölzel D Tags: Breast Source Type: research

When to assess the DIEP flap perfusion by intraoperative indocyanine green angiography in breast reconstruction?
CONCLUSIONS: several advantages have been found in performing the ICGA on the donor site to assess the perfusion of the DIEP flap. PMID: 31404745 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - August 5, 2019 Category: Cancer & Oncology Authors: Malagón-López P, Carrasco-López C, García-Senosiain O, Vilà J, Del-Río M, Priego D, Julian-Ibáñez JF, Higueras-Suñe C Tags: Breast Source Type: research

Use of anticoagulation in patients with breast cancer and atrial fibrillation.
PMID: 31358410 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - July 23, 2019 Category: Cancer & Oncology Authors: Sorigue M Tags: Breast Source Type: research

Resection margins and local recurrences of impalpable breast cancer: Comparison between radioguided occult lesion localization (ROLL) and radioactive seed localization (RSL).
TJ Abstract OBJECTIVES: The aim of this retrospective study is to compare surgical margins, reoperation rates and local recurrences after breast conserving surgery (BCS) using radioguided occult lesion localization (ROLL) or radioactive seed localization (RSL). MATERIALS AND METHODS: We reviewed 744 consecutive patients with impalpable primary invasive breast cancer who underwent BCS at Helsinki University Hospital between 2010 and 2012. ROLL was used in our unit until October 31st, 2011; from November 1st we changed localization method to RSL. RESULTS: 318 patients underwent ROLL and 426 RSL. Patients ...
Source: Breast - July 23, 2019 Category: Cancer & Oncology Authors: Niinikoski L, Hukkinen K, Leidenius MHK, Vaara P, Voynov A, Heikkilä P, Mattson J, Meretoja TJ Tags: Breast Source Type: research

BMI is an independent prognostic factor for late outcome in patients diagnosed with early breast cancer: A landmark survival analysis.
PMID: 31357134 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - July 20, 2019 Category: Cancer & Oncology Authors: Vernaci G, Dieci MV, Manfrin S, Mantiero M, Falci C, Faggioni G, Mioranza E, Menichetti A, Tasca G, Griguolo G, Miglietta F, Di Liso E, Saibene T, Michieletto S, Ghiotto C, Conte P, Guarneri V Tags: Breast Source Type: research

Are mammographic density phenotypes associated with breast cancer treatment response and clinical outcomes? A systematic review and meta-analysis.
We examined the association of baseline MD (BMD), and MD reduction (MDR) following BC treatment with patient outcomes. Six databases (CINAHL, Scopus, PubMed, Web of Science, MEDLINE, and Embase) were used to identify relevant articles. The PRISMA strategy was used to extract relevant details. Study quality and risk of bias were assessed using the "Quality In Prognosis Studies" (QUIPS) tool. A Meta-analysis and pooled risk estimates were performed. Results showed that BMD is associated with contralateral breast cancer (CBC) risk (HR = 1.9; 95%CI: 1.3-3.0, p = 0.0007), recurrence (HR = 2.0; 95%CI: 1.0-4...
Source: Breast - July 18, 2019 Category: Cancer & Oncology Authors: Kanbayti IH, Rae WID, McEntee MF, Ekpo EU Tags: Breast Source Type: research

Nomogram for predicting the overall survival of patients with inflammatory breast cancer: A SEER-based study.
CONCLUSIONS: A nomogram was constructed to predict the OS for IBC patients based on the SEER database and to provide accurate and individualised survival predictions. PMID: 31351202 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - July 17, 2019 Category: Cancer & Oncology Authors: Pan X, Yang W, Chen Y, Tong L, Li C, Li H Tags: Breast Source Type: research

Effectiveness and safety of surgical glove compression therapy as a prophylactic method against nanoparticle albumin-bound-paclitaxel-induced peripheral neuropathy.
CONCLUSIONS: This study suggested the safety and efficacy of SG-compression therapy for the amelioration of CIPN. CLINICAL TRIAL NUMBER: UMIN 000024836. PMID: 31302389 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - July 3, 2019 Category: Cancer & Oncology Authors: Tsuyuki S, Yamagami K, Yoshibayashi H, Sugie T, Mizuno Y, Tanaka S, Kato H, Okuno T, Ogura N, Yamashiro H, Takuwa H, Kikawa Y, Hashimoto T, Kato T, Takahara S, Katayama T, Yamauchi A, Inamoto T Tags: Breast Source Type: research

Is higher dose radiation necessary for positive resection margin after breast-conserving surgery for breast cancer?
CONCLUSIONS: Among the patients with invasive carcinoma or DCIS within less than 1 mm from the resection margin, adjuvant RT with higher dose > 66Gy EQD2 might improve local control. Further prospective studies are warranted to validate the benefit and risk of a high dose boost after BCS in patients with a positive resection margin. PMID: 31265973 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 25, 2019 Category: Cancer & Oncology Authors: Cho WK, Choi DH, Park W, Kim H, Cha H Tags: Breast Source Type: research

Patient-reported fatigue in breast cancer patients receiving radiation therapy.
This study aimed to identify characteristics associated with fatigue in breast cancer patients receiving adjuvant RT. METHODS: Patients with non-metastatic breast cancer receiving RT at the Odette Cancer Centre from 2011 to 2017 were included in our study if they completed at least one ESAS pre- and post-RT. Information regarding patient, disease and treatment characteristics was retrieved from chart review. To identify variables associated with fatigue scores pre-RT, post-RT and changes in fatigue scores, a univariate and multivariate general linear regression analysis was conducted; p 
Source: Breast - June 19, 2019 Category: Cancer & Oncology Authors: Wan BA, Pidduck W, Zhang L, Nolen A, Drost L, Yee C, Chow S, Chan S, Soliman H, Leung E, Sousa P, Lewis D, DeAngelis C, Taylor P, Chow E Tags: Breast Source Type: research

Anthracycline could be essential for triple-negative breast cancer: A randomised phase II study by the Kanagawa Breast Oncology Group (KBOG) 1101.
CONCLUSION: TC6 was not as effective as FEC-D for treating HR-negative BC, as TC6 was not sufficient to treat TNBC, particularly the basal subtype. Our findings suggest that anthracyclines are better treatment options than taxanes for basal BC. PMID: 31229857 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 15, 2019 Category: Cancer & Oncology Authors: Narui K, Ishikawa T, Shimizu D, Yamada A, Tanabe M, Sasaki T, Oba MS, Morita S, Nawata S, Kida K, Mogaki M, Doi T, Tsugawa K, Ogata H, Ota T, Kosaka Y, Sengoku N, Kuranami M, Niikura N, Saito Y, Suzuki Y, Suto A, Arioka H, Chishima T, Ichikawa Y, Endo I, Tags: Breast Source Type: research

Multidisciplinary team meeting and EUSOMA quality indicators in breast cancer care: A French regional multicenter study.
CONCLUSIONS: In this multicentric study evaluating the quality of BC care with a representative sample of institutions, compliance with EUSOMA indicators was satisfactory for all type of institutions. However, too few patients were discussed in pre-therapeutic MTM (especially in non-university hospitals 43.7% [39.4-48.1]) versus 88.7% for others [82.2-95.1]) and data transcription was likely responsible for up to 15% of discordance. PMID: 31226572 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 7, 2019 Category: Cancer & Oncology Authors: Pons-Tostivint E, Daubisse-Marliac L, Grosclaude P, Oum Sack E, Goddard J, Morel C, Dunet C, Sibrac L, Lagadic C, Bauvin E, Bergé Y, Bernard-Marty C, Vaysse C, Lacaze JLL, EvaSein Group Tags: Breast Source Type: research

Utility of diagnostic breast excision biopsies during two decades of screening mammography.
CONCLUSIONS: Although the use of excision biopsy significantly decreased over the past two decades, we observed a significant increased rate in more recent years. Since the vast majority of currently performed excision biopsies reveals a benign diagnosis or shows low grade DCIS, a secondary excision biopsy should only be considered if radiologic surveillance and repeated percutaneous biopsy continues to yield indeterminate results. PMID: 31195315 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 1, 2019 Category: Cancer & Oncology Authors: Luiten JD, Voogd AC, Tjan-Heijnen VCG, Wesseling J, Luiten EJT, Duijm LEM Tags: Breast Source Type: research

Acupuncture on aromatase inhibitor-induced arthralgia in patients with breast cancer.
PMID: 31029376 [PubMed - in process] (Source: Breast)
Source: Breast - April 29, 2019 Category: Cancer & Oncology Authors: Zhang K, Tang Q Tags: Breast Source Type: research

De-escalation of complexity in oncoplastic breast surgery: Case series from a specialized breast center.
CONCLUSIONS: This study hypothesizes that a proper information may impact on patient's decisions and may reduce surgical complexity. This reduction likely has no effects on the main surgical outcomes estimated using standard tools. More investigations should be performed on a larger multi-institutional scale to confirm these conclusions. PMID: 30999077 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 9, 2019 Category: Cancer & Oncology Authors: Catanuto G, Khan A, Ursino V, Pietraforte E, Scandurra G, Ravalli C, Rocco N, Nava MB, Catalano F Tags: Breast Source Type: research

Corrigendum to "Adherence to adjuvant endocrine therapy in postmenopausal breast cancer patients: A 5-year prospective study" [The Breast, 44, April 2019, 52-58].
Corrigendum to "Adherence to adjuvant endocrine therapy in postmenopausal breast cancer patients: A 5-year prospective study" [The Breast, 44, April 2019, 52-58]. Breast. 2019 Apr 05;45:118 Authors: Hagen KB, Aas T, Kvaløy JT, Søiland H, Lindb R PMID: 30959387 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 5, 2019 Category: Cancer & Oncology Authors: Hagen KB, Aas T, Kvaløy JT, Søiland H, Lindb R Tags: Breast Source Type: research

Low eicosapentaenoic acid and gamma-linolenic acid levels in breast adipose tissue are associated with inflammatory breast cancer.
CONCLUSION: These differences in lipid content may contribute to the occurrence of breast cancer inflammation. PMID: 30959386 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 1, 2019 Category: Cancer & Oncology Authors: Chas M, Goupille C, Arbion F, Bougnoux P, Pinault M, Jourdan ML, Chevalier S, Ouldamer L Tags: Breast Source Type: research

Acceptance of contralateral reduction mammoplasty after oncoplastic breast conserving surgery: A semi-structured qualitative interview study.
CONCLUSION: Breast asymmetry is often tolerated after oncoplastic BCS because of concerns about surgery risks and recovery time and reluctance to have nonessential surgery to the healthy breast. PMID: 30928763 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 25, 2019 Category: Cancer & Oncology Authors: Smeele HP, Van der Does de Willebois EML, Eltahir Y, De Bock GH, Van Aalst VC, Jansen L Tags: Breast Source Type: research

Locoregional surgical treatment improves the prognosis in primary metastatic breast cancer patients with a single distant metastasis except for brain metastasis.
CONCLUSIONS: The effect of locoregional surgery has been underestimated in pMBC patients. Surgical procedures should be seriously considered when planning combination treatments for pMBC patients with a single metastasis except for brain metastasis. PMID: 30928762 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 23, 2019 Category: Cancer & Oncology Authors: Li X, Huang R, Ma L, Liu S, Zong X Tags: Breast Source Type: research

Potential gain in life years for Swedish women with breast cancer if stage and survival differences between education groups could be eliminated - Three what-if scenarios.
This study aimed to quantify the impact of removing differences in stage distribution and stage-specific relative survival between education groups in Swedish women with breast cancer. Using information from a breast cancer research database, the study population contained 62 121 women diagnosed with breast cancer in three healthcare regions of Sweden from 1992 to 2012. The loss in expectation of life and life years lost due to breast cancer were estimated using flexible parametric relative survival models by education group and age at diagnosis. The potential gain in life years and postponable deaths were calculated by ...
Source: Breast - March 12, 2019 Category: Cancer & Oncology Authors: Bower H, Andersson TM, Syriopoulou E, Rutherford MJ, Lambe M, Ahlgren J, Dickman PW, Lambert PC Tags: Breast Source Type: research

Should women with a BRCA1/2 mutation aged 60 and older be offered intensified breast cancer screening? - A cost-effectiveness analysis.
CONCLUSION: Of the three alternative strategies, only alternating annual MRI and mammography for BRCA2 mutation carriers and dense breasts aged 60-75 is cost-effective compared to annual mammography. For BRCA1 mutation carriers, none of the alternative strategies is cost-effective compared to the next best strategy. PMID: 30904701 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 12, 2019 Category: Cancer & Oncology Authors: Phi XA, Greuter MJW, Obdeijn IM, Oosterwijk JC, Feenstra TL, Houssami N, de Bock GH Tags: Breast Source Type: research

Towards evidence-based follow-up intervals for breast cancer survivors: Estimates of the preclinical detectable phase of contralateral second breast cancer.
Abstract PURPOSE: Follow-up schemes in breast cancer survivors are predominantly consensus-based. To determine evidence-based follow-up intervals, estimates of sensitivity of the screening test(s) and duration of the preclinical detectable phase (PCDP) are key. We estimated the sensitivity and the duration of the PCDP of clinical breast examination (CBE) and mammography for the detection of contralateral second breast cancers (CBC) in breast cancer survivors. METHODS: Women with a CBC (N = 589) diagnosed in Florence between 1980 and 2005 were included. Test sensitivity and the duration of PCDP were estima...
Source: Breast - March 8, 2019 Category: Cancer & Oncology Authors: Aarts AMWM, Duffy SW, Geurts SME, Vulkan DP, Houssami N, Zappa M, Nagtegaal ID, Verbeek ALM, Broeders MJM Tags: Breast Source Type: research

Secondary breast angiosarcoma: A multicentre retrospective survey by the national Italian association of Breast Surgeons (ANISC).
CONCLUSIONS: Secondary breast angiosarcoma is a very aggressive disease associated with a short survival outcome. The surgical approach still remains an important step in the course of treatment; furthermore, an accurate histological examination is helpful in establishing the prognosis of the patient. A mastectomy is mandatory. A longer OS was observed in patients with low-grade angiosarcoma as compared to high-grade angiosarcoma (C.I. 40-57 vs. 31-41 months). PMID: 30877870 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 7, 2019 Category: Cancer & Oncology Authors: Taffurelli M, Pellegrini A, Meattini I, Orzalesi L, Tinterri C, Roncella M, Terribile D, Caruso F, Tazzioli G, Pollini G, Friedman D, Mariotti C, Cianchetti E, Cabula C, Thomas R, Cedolini C, Rovera F, Grassi M, Lucani G, Cappella A, Bortul M, Stacul G, S Tags: Breast Source Type: research

Causes of sick leave, disability pension, and death following a breast cancer diagnosis in women of working age.
CONCLUSION: Follow-up, support, and rehabilitation programs for women diagnosed with breast cancer must address a wide range of psychological and physical conditions to limit the consequences on working life. PMID: 30852409 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 2, 2019 Category: Cancer & Oncology Authors: Plym A, Johansson ALV, Bower H, Voss M, Holmberg L, Fredriksson I, Lambe M Tags: Breast Source Type: research

Is tumor bed boost necessary in patients who achieved ypCR following neoadjuvant chemotherapy and breast conserving therapy? (KROG 12-05 and 16-16).
Abstract PURPOSE: This multi-institutional study intended to investigate the effect of tumor bed boost in patients who achieved pathologic complete response (ypCR) following neoadjuvant chemotherapy (NAC) and breast-conserving therapy (BCT). MATERIALS AND METHODS: We identified 180 patients who initially had lymph node (LN) metastasis and achieved ypCR (ypT0/isN0) following NAC and BCT from the 13 institutions of the Korean Radiation Oncology Group (KROG) 16-16 and KROG 12-05. The effect of tumor bed boost on loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) rates was analyze...
Source: Breast - February 26, 2019 Category: Cancer & Oncology Authors: Cho WK, Park W, Choi DH, Kim YB, Suh CO, Shin KH, Chie EK, Kim JH, Ahn SD, Kim SS, Kim K, Kim JH, Ahn SJ, Lee SY, Lee J, Kim SW, Kwon J, Ahn KJ, Shin HS, Lee HS, Lee NK Tags: Breast Source Type: research

Comparison of 4th ESO-ESMO international consensus guidelines for advance breast cancer and Chinese anti-cancer association committee of Breast Cancer Society guideline.
Abstract The primary aim of the international advance breast cancer (ABC) guidelines are to guide treatment decisions in many different healthcare settings, but need adaptations due to different access to care. These guidelines are based on the most up-to-date evidence. However, Chinese experts have a different national condition and policies to face. The Chinese Anti-Cancer Association Committee of Breast Cancer Society guideline (CBCS guideline) is to guide treatments and to reflect unmet needs of Chinese breast cancer patients. Although, most of the recommendations in the two guidelines are the same, some of th...
Source: Breast - February 22, 2019 Category: Cancer & Oncology Authors: Hu X, Li T, Wang B, Zhang J, Yu X, Shao Z Tags: Breast Source Type: research

Homologous recombination deficiency in triple negative breast cancer.
Abstract Triple negative breast cancer (TNBC) represents a heterogeneous subtype of breast cancer characterized by an unfavorable prognosis due to its aggressive biology. The median overall survival (OS) for patients with metastatic TNBC is around 9-12 months with conventional cytotoxic agents. Considering this suboptimal outcome, which is induced despite of medical treatment, new therapeutic strategies would be urgently needed. The ultimate goal of precision medicine is to identify specific molecular alterations that permit considering effective targeted drug(s). Germline BRCA mutations occur in 10-20% of TNBC pa...
Source: Breast - February 20, 2019 Category: Cancer & Oncology Authors: Belli C, Duso BA, Ferraro E, Curigliano G Tags: Breast Source Type: research

Predictors of weight gain in a cohort of premenopausal early breast cancer patients receiving chemotherapy.
Abstract AIM: In breast cancer patients, post chemotherapy weight gain is linked with increased risk of cancer recurrence. We prospectively studied a cohort of premenopausal women receiving contemporary chemotherapy following a diagnosis of breast cancer to examine factors predicting weight increase. METHODS: Between May 2005 and January 2008, 523 patients from the Prospective Outcomes in Sporadic versus Hereditary (POSH) breast cancer study entered this sub-study comparing weight prior to chemotherapy and weight and waist/hip measurements 12-months following chemotherapy. RESULTS: Data from 380 patients...
Source: Breast - February 15, 2019 Category: Cancer & Oncology Authors: Gandhi A, Copson E, Eccles D, Durcan L, Howell A, Morris J, Howell S, McDiarmid S, Sellers K, Gareth Evans D, Harvie M Tags: Breast Source Type: research

Physical activity in breast cancer survivors: A systematic review and meta-analysis on overall and breast cancer survival.
CONCLUSION: Highest recreational PA after breast cancer diagnosis was associated with lower all-cause and breast cancer mortality. This finding probably reflects the favorable impact of PA on cardiovascular mortality, and a possible favorable role on breast cancer survival, though reverse causation cannot be excluded. PMID: 30780085 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - February 12, 2019 Category: Cancer & Oncology Authors: Spei ME, Samoli E, Bravi F, La Vecchia C, Bamia C, Benetou V Tags: Breast Source Type: research

Peptide vaccines in early breast cancer.
Abstract The immune system plays a dual role of host-protecting and tumor-promoting, as elegantly expressed by the 'cancer immunoediting' hypothesis. Although breast cancer has not been traditionally considered to be immunogenic, recently there is accumulating and solid evidence on the association between immune system and breast cancer. To mount an effective anti-tumor response, host immunosurveillance must recognize tumor-specific epitopes, thus defining the antigenicity of a tumor. Neoantigens are mutant cancer peptides that arise as terminal products of the expression of somatic cancer mutations. Neoantigens a...
Source: Breast - February 7, 2019 Category: Cancer & Oncology Authors: Criscitiello C, Viale G, Curigliano G Tags: Breast Source Type: research

Effects of pessimism, depression, fatigue, and pain on functional health-related quality of life in patients with resected non-advanced breast cancer.
CONCLUSION: This study reveals the impact of depression and pessimism on physical, psychological, social, and quality-of-life aspects and the importance of evaluating them in patients who are going to initiate adjuvant chemotherapy for breast cancer. PMID: 30735899 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - February 2, 2019 Category: Cancer & Oncology Authors: Calderon C, Carmona-Bayonas A, Hernández R, Ghanem I, Castelo B, Martinez de Castro E, Ferreira E, Ciria L, Muñiz M, Jimenez-Fonseca P Tags: Breast Source Type: research

Characteristics and prognosis of stage I-III breast cancer subtypes in Brazil: The AMAZONA retrospective cohort study.
CONCLUSIONS: Brazilian women have a higher risk of being diagnosed with late stage breast cancer and younger age than in high-income countries. Luminal-like disease is the most common molecular subtype in the country. Triple negative and HER-2 positive had the worst prognosis. PMID: 30738289 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - February 2, 2019 Category: Cancer & Oncology Authors: Simon SD, Bines J, Werutsky G, Nunes JS, Pacheco FC, Segalla JG, Gomes AJS, Adam Van Eyll BMHR, Gimenes DL, Crocamo S, Freitas-Junior R, Lago LD, Queiroz GS, Jobim de Azevedo S, Rosa DD, Delgado G, Borges GS, Verônica do Nascimento Y, Zaffaroni F, Martí Tags: Breast Source Type: research

EUSOMA position regarding breast implant associated anaplastic large cell lymphoma (BIA-ALCL) and the use of textured implants.
Abstract During the last two decades the number of breast implants used in aesthetic, oncologic and risk reducing surgery has increased substantially mainly due to the improvement and confirmed safety of these devices. Since identification of the first case of anaplastic large cell lymphoma associated with a breast implant (BIA-ALCL) 20 years ago, there has been an increase in the number of reports of this very rare disease, demonstrating a clear association with breast implants. Whilst the majority of cases are localised and cured by implant removal and full capsulectomy, a small percentage require chemotherapy a...
Source: Breast - January 26, 2019 Category: Cancer & Oncology Authors: Cardoso MJ, Wyld L, Rubio IT, Leidenius M, Curigliano G, Cutuli B, Marotti L, Biganzoli L Tags: Breast Source Type: research

The impact of the 21-gene recurrence score (Oncotype DX) on concordance of adjuvant therapy decision making as measured by the Liverpool Systemic Therapy Adjuvant Decision Tool.
Abstract PURPOSE: The 21-gene recurrence score (Oncotype DX) (RS) informs systemic therapy decision making in ER-positive HER2-negative early breast cancer (BC). To date no study has described the more nuanced discussions that take place regarding systemic therapy or the impact of the RS on concordance in such decision making. Here we utilized a novel decision making tool to assess the impact of the RS on decision making as well as concordance of treatment recommendations. PATIENTS AND METHODS: The clinicopathological information (CPI) of 50 BCs without and with the RS were presented to a panel of breast on...
Source: Breast - January 18, 2019 Category: Cancer & Oncology Authors: Olsson-Brown A, Piskilidis P, O'Hagan J, Thorp N, Robson P, Innes H, Wong H, Cicconi S, Jackson R, Kiernan T, Holcombe C, O'Reilly S, Palmieri C Tags: Breast Source Type: research

Cancer treatment effects on cognition and depression: The moderating role of physical activity.
CONCLUSION: The results from this study support the importance of examining mediating factors in the effects of cancer treatment on cognition, particularly depression, following cancer treatment. Effects of treatment on cognition in breast cancer survivors are partially explained by changes in depressive symptoms, although chemotherapy may impact cognition independent of depression. Importantly, physical activity may reduce the risk of depression and cognitive impairment in breast cancer survivors. PMID: 30685529 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - January 16, 2019 Category: Cancer & Oncology Authors: Bedillion MF, Ansell EB, Thomas GA Tags: Breast Source Type: research

Adherence to adjuvant endocrine therapy in postmenopausal breast cancer patients: A 5-year prospective study.
CONCLUSION: Closer follow-ups, tailor-made information about the proven benefits of ET, and keeping a normal body mass index (BMI) may improve adherence to ET in postmenopausal women with breast cancer. PMID: 30641300 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - January 8, 2019 Category: Cancer & Oncology Authors: Hagen KB, Aas T, Kvaløy JT, Søiland H, Lind R Tags: Breast Source Type: research

A real-life study on the implementation and effectiveness of exemestane plus everolimus per hospital type in patients with advanced breast cancer. A study of the Southeast Netherlands Advanced Breast Cancer registry.
CONCLUSIONS: In our study, the median PFS was borderline significantly different between hospital types, possibly the result of a different assessment approach in the first 12-week treatment period. PMID: 30641299 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - January 4, 2019 Category: Cancer & Oncology Authors: Knapen LM, Geurts SME, Ibragimova KIE, Croes S, Vriens BEPJ, van den Berkmortel FWPJ, Dercksen MW, van de Wouw AJ, Pepels MJAE, de Fallois AOJ, Lobbezoo DJA, de Boer M, Tjan-Heijnen VCG Tags: Breast Source Type: research

Results of PONDx, a prospective multicenter study of the Oncotype DX ® breast cancer assay: Real-life utilization and decision impact in French clinical practice.
Results of PONDx, a prospective multicenter study of the Oncotype DX® breast cancer assay: Real-life utilization and decision impact in French clinical practice. Breast. 2019 Jan 03;44:39-45 Authors: Curtit E, Vannetzel JM, Darmon JC, Roche S, Bourgeois H, Dewas S, Catala S, Mereb E, Fanget CF, Genet D, Forest AM, Bernier C, Pivot X Abstract Adjuvant chemotherapy shows clear benefits in HER2-positive and triple-negative breast cancer (BC). Its benefits are less universal in BCs expressing hormone receptors. The 21-gene Oncotype DX® Breast Recurrence Score test was designed for HR+, HER2- early...
Source: Breast - January 3, 2019 Category: Cancer & Oncology Authors: Curtit E, Vannetzel JM, Darmon JC, Roche S, Bourgeois H, Dewas S, Catala S, Mereb E, Fanget CF, Genet D, Forest AM, Bernier C, Pivot X Tags: Breast Source Type: research

Combination of peripheral neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio is predictive of pathological complete response after neoadjuvant chemotherapy in breast cancer patients.
Abstract The immune system seems to play a fundamental role in breast cancer responsiveness to chemotherapy. We investigated two peripheral indicators of immunity/inflammation, i.e. neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR), in order to reveal a possible relationship with pathological complete response (pCR) in patients with early or locally advanced breast cancer treated with neoadjuvant chemotherapy (NACT). We retrospectively analyzed 373 consecutive patients affected by breast cancer and candidates to NACT. The complete blood cell count before starting NACT was evaluated to cal...
Source: Breast - January 2, 2019 Category: Cancer & Oncology Authors: Graziano V, Grassadonia A, Iezzi L, Vici P, Pizzuti L, Barba M, Quinzii A, Camplese A, Di Marino P, Peri M, Veschi S, Alberti S, Gamucci T, Di Gioacchino M, De Tursi M, Natoli C, Tinari N Tags: Breast Source Type: research

Unemployment following breast cancer diagnosis: A population-based study.
CONCLUSIONS: Breast cancer survivorship was associated with long-term risk of unemployment. Older patients and patients with lower socio-economic status were at increased risk of unemployment. PMID: 30597404 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - December 27, 2018 Category: Cancer & Oncology Authors: Grinshpun A, Rottenberg Y Tags: Breast Source Type: research

Is trastuzumab as a single agent obsolete in early breast cancer? No.
Abstract Until very recently, the "one size fits all" approach, with trastuzumab and chemotherapy with or without endocrine therapy, has been considered standard of care in almost all patients with HER2-positive early breast cancer. The combination of trastuzumab and chemotherapy is considered an undeniable therapy in this setting, given the unquestionable clinical benefit and the favorable safety profile. This almost universal adoption of trastuzumab-based therapies in early breast cancer has led to a proportional increase of overtreated patients, thus making treatment de-escalation in HER2-positive ear...
Source: Breast - December 18, 2018 Category: Cancer & Oncology Authors: Bianchini G Tags: Breast Source Type: research