Clinicopathological characteristics of gene-positive breast cancer in the United Arab Emirates.
CONCLUSIONS: This is the first study in the UAE to describe the clinical and pathological characteristics of hereditary breast cancer in a mixed ethnic group with dominant Arabic population. Further genetic studies will be required in the UAE population, as the prevalence of breast cancer continues to rise. PMID: 32745951 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - July 27, 2020 Category: Cancer & Oncology Authors: Altinoz A, Al Ameri M, Qureshi W, Boush N, Nair SC, Abdel-Aziz A Tags: Breast Source Type: research

Genome-wide chromosomal instability by cell-free DNA sequencing predicts survival in patients with metastatic breast cancer.
CONCLUSIONS: To our knowledge, this is the first study illustrating the prognostic value of chromosomal instability derived from cfDNA in MBC. PMID: 32738630 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - July 25, 2020 Category: Cancer & Oncology Authors: Mo H, Wang X, Ma F, Qian Z, Sun X, Yi Z, Guan X, Li L, Liu B, Xu B Tags: Breast Source Type: research

Sequential immunohistochemistry and virtual image reconstruction using a single slide for quantitative KI67 measurement in breast cancer.
CONCLUSIONS: KiQuant represents an easy and accurate methodology for Ki67 measurement providing a step toward utilizing Ki67 in the clinical setting. PMID: 32707454 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - July 13, 2020 Category: Cancer & Oncology Authors: Serna G, Simonetti S, Fasani R, Pagliuca F, Guardia X, Gallego P, Jimenez J, Peg V, Saura C, Eppenberger-Castori S, Ramon Y Cajal S, Terracciano L, Nuciforo P Tags: Breast Source Type: research

Margin dilemma in vacuum-assisted excisional BIOPSY to treat benign phyllodes tumors.
PMID: 32683250 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - July 4, 2020 Category: Cancer & Oncology Authors: Irkorucu O Tags: Breast Source Type: research

Comparison of complications according to incision types in nipple-sparing mastectomy and immediate reconstruction.
Abstract BACKGROUND: Nipple-sparing mastectomy (NSM), followed by immediate reconstruction (IR) of the breast, has become a preferred surgical procedure with good cosmesis results and patient satisfaction. However, nipple-areolar complex (NAC) ischemia and necrosis remain major problems after NSM and IR. METHODS: We retrospectively analyzed patients who underwent NSM and IR at Gangnam Severance Hospital from January 2009 to June 2018. We compared the patient characteristics and complication rate among three different incisions (inframammary fold [IMF], radial, periareolar). Additionally, we identified the ris...
Source: Breast - July 3, 2020 Category: Cancer & Oncology Authors: Park S, Yoon C, Bae SJ, Cha C, Kim D, Lee J, Ahn SG, Roh TS, Kim YS, Jeong J Tags: Breast Source Type: research

Effect of multidisciplinary team care on the risk of recurrence in breast cancer patients: A national matched cohort study.
CONCLUSIONS: The relative risk of recurrence and death was significantly lower for breast cancer patients who received MDT care than for those who did not. We suggest that MDT care be implanted in the National Health Policy settings of breast cancer patients. PMID: 32652461 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - July 3, 2020 Category: Cancer & Oncology Authors: Tsai CH, Hsieh HF, Lai TW, Kung PT, Kuo WY, Tsai WC Tags: Breast Source Type: research

Improving medication adherence with adjuvant aromatase inhibitor in women with breast cancer: A randomised controlled trial to evaluate the effect of short message service (SMS) reminder.
CONCLUSION: SMS reminder improved medication adherence in the short-term but had no effect on serum hormones levels in the longer term. Future studies could investigate the use of tailored SMS intervention according to patient preference to improve its sustainability. PMID: 32652462 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - July 2, 2020 Category: Cancer & Oncology Authors: Tan EH, Wong ALA, Tan CC, Wong P, Tan SH, Ang LEY, Lim SE, Chong WQ, Ho J, Lee SC, Tai BC Tags: Breast Source Type: research

Influence of adherence with guideline-driven recommendations on survival in women operated for breast cancer: Real-life evidence from Italy.
CONCLUSIONS: Clinical benefits are expected from improvements in adherence to the considered recommendations. Close control of women operated for breast cancer through medical care timeliness and appropriateness of radiotherapy and mammographic monitoring must be considered the cornerstone of national guidance, national audits, and quality improvement incentive schemes. PMID: 32629156 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - July 1, 2020 Category: Cancer & Oncology Authors: Corrao G, Rea F, Di Felice E, Di Martino M, Davoli M, Merlino L, Carle F, De Palma R, “Monitoring and assessing diagnostic-therapeutic paths (MAP)” of the Italian Ministry of Health Tags: Breast Source Type: research

Psychosocial aspects and life project disruption in young women diagnosed with metastatic hormone-sensitive HER2-negative breast cancer.
ez RV Abstract Metastatic breast cancer (MBC) diagnosis in young women negatively impacts on quality of life (QoL) and daily activities, disrupting their life project and forcing them to face new psychosocial challenges. The recently published results on the improvement of the overall survival of pre- or perimenopausal women with hormone-receptor-positive, HER2-negative MBC treated with CDK4/6 inhibitors plus endocrine therapy, while preserving, and in some items improving their QoL, will change the landscape of the management of this patient population. Their extended survival and potential improvement in QoL wil...
Source: Breast - June 26, 2020 Category: Cancer & Oncology Authors: Vila MM, Barco Berron SD, Gil-Gil M, Ochoa-Arnedo C, Vázquez RV Tags: Breast Source Type: research

Reply to Ivica Ratosa et  al. Comment on: "Multidisciplinary team meeting and EUSOMA quality indicators in breast cancer care: A French regional multicenter study".
Reply to Ivica Ratosa et al. Comment on: "Multidisciplinary team meeting and EUSOMA quality indicators in breast cancer care: A French regional multicenter study". Breast. 2020 Jun 20;53:42 Authors: Pons-Tostivint E, Grosclaude P, Daubisse-Marliac L PMID: 32585560 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 20, 2020 Category: Cancer & Oncology Authors: Pons-Tostivint E, Grosclaude P, Daubisse-Marliac L Tags: Breast Source Type: research

A video-game based cognitive training for breast cancer survivors with cognitive impairment: A prospective randomized pilot trial.
Abstract INTRODUCTION: We investigated whether a web-based cognitive training video game is an effective approach to improve cognitive decline in combination with our standard of care for rehabilitation of breast cancer (BC) patients. MATERIALS AND METHODS: Self-selected BC patients between 18 and 71 years old complaining of disturbing cognitive impairment were studied. The patients received access to a web-based internet video game and online cognitive assessments (Aquasnap, Cambridge, MyCQ™). The early intervention group (n = 23) had a training program of 6 months of at least three times a w...
Source: Breast - June 12, 2020 Category: Cancer & Oncology Authors: Bellens A, Roelant E, Sabbe B, Peeters M, van Dam PA Tags: Breast Source Type: research

Diagnostic accuracy of contrast-enhanced spectral mammography for breast lesions: A systematic review and meta-analysis.
Abstract Breast cancer diagnosis and staging is based on mammography, ultrasound, and magnetic resonance imaging (MRI). Contrast enhanced spectral mammography (CESM) has gained momentum as an innovative and clinically useful method for breast assessment. CESM is based on abnormal enhancement of neoplastic tissue compared to surrounding breast tissue. We performed a systematic review of prospective trial to evaluate its diagnostic performance, following standard PRISMA-DTA. We used a bivariate random-effects regression approach to obtain summary estimates of both sensitivity and specificity of CESM. 8 studies publi...
Source: Breast - June 10, 2020 Category: Cancer & Oncology Authors: Suter MB, Pesapane F, Agazzi GM, Gagliardi T, Nigro O, Bozzini A, Priolo F, Penco S, Cassano E, Chini C, Squizzato A Tags: Breast Source Type: research

Metronomic oral chemotherapy with cyclophosphamide plus capecitabine combined with trastuzumab (HEX) as first line therapy of HER-2 positive advanced breast cancer: A phase II trial of the Gruppo Oncologico Italia Meridionale (GOIM).
CONCLUSIONS: Combination of trastuzumab and metronomic oral chemotherapy has clinical activity. The tolerability was excellent and allowed the prolonged delivery of treatment. PMID: 32540553 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 5, 2020 Category: Cancer & Oncology Authors: Orlando L, Lorusso V, Giotta F, Di Maio M, Schiavone P, Fedele P, Quaranta A, Caliolo C, Ciccarese M, Cinefra M, Romito S, Pisconti S, Prete SD, Aieta M, Rizzi D, Maiello E, Colucci G, Cinieri S Tags: Breast Source Type: research

Estimation of historical control rate for a single arm de-escalation study - Application to the POSITIVE trial.
CONCLUSION: External control datasets should be identified before launching single-arm, de-escalation trials and methods applied during their conduct to provide context for interim monitoring and interpretation of the final analysis. PMID: 32535486 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 2, 2020 Category: Cancer & Oncology Authors: Sun Z, Niman SM, Pagani O, Partridge AH, Azim HA, Peccatori FA, Ruggeri M, Di Leo A, Colleoni M, Gelber RD, Regan MM, POSITIVE Steering Committee Tags: Breast Source Type: research

Henoch-sch önlein Purpura (HSP) in a patient on Abemaciclib.
Henoch-schönlein Purpura (HSP) in a patient on Abemaciclib. Breast. 2020 Jun 02;52:132-133 Authors: Omarini C, Molinaro E, Barbolini M, Dominici M, Piacentini F PMID: 32512359 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 2, 2020 Category: Cancer & Oncology Authors: Omarini C, Molinaro E, Barbolini M, Dominici M, Piacentini F Tags: Breast Source Type: research

The affect of goserelin on the QoL of women having chemotherapy for EBC: Results from the OPTION trial.
CONCLUSIONS: These results show that young women diagnosed with breast cancer experienced only a short-term decrease in QoL from the addition of goserelin, in order to preserve ovarian function during chemotherapy treatment. PMID: 32505861 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - May 29, 2020 Category: Cancer & Oncology Authors: R L, A Y, J M, L F, V J Tags: Breast Source Type: research

Changes in breast cancer management during the Corona Virus Disease 19 pandemic: An international survey of the European Breast Cancer Research Association of Surgical Trialists (EUBREAST).
Abstract BACKGROUND: Corona Virus Disease 19 (COVID-19) had a worldwide negative impact on healthcare systems, which were not used to coping with such pandemic. Adaptation strategies prioritizing COVID-19 patients included triage of patients and reduction or re-allocation of other services. The aim of our survey was to provide a real time international snapshot of modifications of breast cancer management during the COVID-19 pandemic. METHODS: A survey was developed by a multidisciplinary group on behalf of European Breast Cancer Research Association of Surgical Trialists and distributed via breast cancer soc...
Source: Breast - May 29, 2020 Category: Cancer & Oncology Authors: Gasparri ML, Gentilini OD, Lueftner D, Kuehn T, Kaidar-Person O, Poortmans P Tags: Breast Source Type: research

The impact of menstruation persistence or recovery after chemotherapy on survival in young patients with hormone receptor negative breast cancer.
CONCLUSION: No significantly increased recurrence risk was found for hormone receptor-negative BC patients with recovery of menstruation after chemotherapy. However, the outcome of the multivariable model is not reassuring and a potentially increased recurrence risk cannot be excluded. The results need to be validated in a larger prospective study for a more definitive answer. PMID: 32497987 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - May 22, 2020 Category: Cancer & Oncology Authors: van Barele M, Heemskerk-Gerritsen BAM, van Doorn HC, Schmidt MK, Hooning MJ, Jager A Tags: Breast Source Type: research

Clinical utility of tumour marker velocity of cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA) in breast cancer surveillance.
CONCLUSION: These findings highlighted the clinical utility of serial tumour markers measurements and its velocity in breast cancer surveillance. PMID: 32485607 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - May 20, 2020 Category: Cancer & Oncology Authors: Hing JX, Mok CW, Tan PT, Sudhakar SS, Seah CM, Lee WP, Tan SM Tags: Breast Source Type: research

Hospital-based or home-based administration of oncology drugs? A micro-costing study comparing healthcare and societal costs of hospital-based and home-based subcutaneous administration of trastuzumab.
CONCLUSIONS: Home-based subcutaneous administration of trastuzumab is more time consuming for healthcare professionals and therefore more costly than hospital-based administration. The total budget impact can be large considering that a large number of patients receive a large number of cycles of oncology treatments. If home-based administration is the way forward, novel approaches are crucial for ensuring efficiency of home-based care. PMID: 32447129 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - May 16, 2020 Category: Cancer & Oncology Authors: Franken M, Kanters T, Coenen J, de Jong P, Jager A, Groot CU Tags: Breast Source Type: research

Late effects of adjuvant chemotherapy adumbrate dormancy complexity in breast cancer.
CONCLUSIONS: Present results reveal the ability of adjuvant chemotherapy to reduce not only the rate of early relapses, but also the rate of intermediate relapses at about the sixth year of follow up. Adjuvant chemotherapy is not impacting on the development of metastases underlying the late peak detected at the tenth year. These findings suggest the existence of a previously unknown dormancy state that, at the primary tumour surgical removal, results in evolving chemo-sensitive metastatic processes, and, moreover, of a later chemo-refractory dormancy state. PMID: 32428688 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - May 8, 2020 Category: Cancer & Oncology Authors: Demicheli R, Desmedt C, Retsky M, Sotiriou C, Piccart M, Biganzoli E Tags: Breast Source Type: research

Fertility in Breast Cancer Survivors in the Middle East: A Retrospective Study.
CONCLUSIONS: The observed rate of pregnancy is comparable to the literature. There is a lack in fertility counseling of breast cancer patients, and the rate of use of fertility preservation techniques is very low despite prior knowledge about their availability. PMID: 32388348 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 29, 2020 Category: Cancer & Oncology Authors: Assi HI, Kakati RT, Attieh RM, Khoury J, Sukhon F, Berro J, Sbaity E, Salem Z, Tfayli A, Alameh IA, El Saghir N Tags: Breast Source Type: research

Impact of age at diagnosis of metastatic breast cancer on overall survival in the real-life ESME metastatic breast cancer cohort.
n M, Cottu P Abstract BACKGROUND: Young age is a poor prognostic factor in early stage breast cancer (BC) but its value is less established in metastatic BC (MBC). We evaluated the impact of age at MBC diagnosis on overall survival (OS) across three age groups ( 60 years(y)). METHODS: ESME MBC database is a national cohort, collecting retrospective data from 18 participating French cancer centers between January 01, 2008 and December 31, 2014. RESULTS: Among 14 403 women included, 1077 (7.5%), 6436 (44.7%) and 6890 (47.8%) pts were  60 y respectively. Pts 60y) and triple negative subt...
Source: Breast - April 23, 2020 Category: Cancer & Oncology Authors: Frank S, Carton M, Dubot C, Campone M, Pistilli B, Dalenc F, Mailliez A, Levy C, D'Hondt V, Debled M, Vermeulin T, Coudert B, Perrin C, Gonçalves A, Uwer L, Ferrero JM, Eymard JC, Petit T, Mouret-Reynier MA, Patsouris A, Guesmia T, Bachelot T, Robain M, Tags: Breast Source Type: research

Accelerated partial breast irradiation with interstitial multicatheter brachytherapy after breast-conserving surgery for low-risk early breast cancer.
ute;n JI, Lara PC Abstract Patients with low-risk invasive ductal carcinoma treated with breast-conserving surgery (BCS) were included in a multicatheter brachytherapy APBI protocol. The primary endpoint was ipsilateral breast recurrence. Between December 2008-December 2017, 186 low-risk breast cancer patients were treated with APBI using interstitial multicatheter brachytherapy and followed prospectively. At 5-years of follow-up, cumulative local recurrence (LR) and cause-specific survival was 1.1% (95% CI 0.3-1.9) and 98.3% (95% CI 97.3-99.3%) respectively. No grade 3 adverse effects were observed. Postoperative...
Source: Breast - April 22, 2020 Category: Cancer & Oncology Authors: Rodriguez-Ibarria NG, Pinar MB, García L, Cabezón MA, Lloret M, Rey-Baltar MD, Rdguez-Melcón JI, Lara PC Tags: Breast Source Type: research

Reply to: "When to assess the flap perfusion by intraoperative indocyanine green angiography (ICGA): On the donor site or the recipient site?"
Reply to: "When to assess the flap perfusion by intraoperative indocyanine green angiography (ICGA): On the donor site or the recipient site?" Breast. 2020 Apr 18;: Authors: Malagón P, Carrasco C, García O, Del-Río M, Higueras C PMID: 32336571 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 18, 2020 Category: Cancer & Oncology Authors: Malagón P, Carrasco C, García O, Del-Río M, Higueras C Tags: Breast Source Type: research

Safety and efficacy of sirolimus combined with endocrine therapy in patients with advanced hormone receptor-positive breast cancer and the exploration of biomarkers.
CONCLUSIONS: Sirolimus is a potentially effective treatment option for patients with HR-positive advanced breast cancer. PMID: 32335491 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 16, 2020 Category: Cancer & Oncology Authors: Yi Z, Liu B, Sun X, Rong G, Wang W, Li H, Guan X, Li L, Zhai J, Li C, Qian H, Ma F, Xu B Tags: Breast Source Type: research

Recommendations for triage, prioritization and treatment of breast cancer patients during the COVID-19 pandemic.
Abstract The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) associated disease (COVID-19) outbreak seriously challenges globally all health care systems and professionals. Expert projections estimate that despite social distancing and lockdown being practiced, we have yet to feel the full impact of COVID-19. In this manuscript we provide guidance to prepare for the impact of COVID-19 pandemic on breast cancer patients and advise on how to triage, prioritize and organize diagnostic procedures, surgical, radiation and medical treatments. PMID: 32334323 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 16, 2020 Category: Cancer & Oncology Authors: Curigliano G, Cardoso MJ, Poortmans P, Gentilini O, Pravettoni G, Mazzocco K, Houssami N, Pagani O, Senkus E, Cardoso F, editorial board of The Breast Tags: Breast Source Type: research

Prospective observational study on the impact of the 21-gene assay on treatment decisions and resources optimization in breast cancer patients in Lombardy: The BONDX study.
CONCLUSIONS: Our real-life experience suggests that all intermediate-risk ER+/HER2-eBC patients who are initially deemed candidates for CHT should be tested with the 21-gene test. The potential to spare CT in at least half of them offers relevant advantages for patients and national health services. PMID: 32325372 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 15, 2020 Category: Cancer & Oncology Authors: Zambelli A, Simoncini E, Giordano M, Laverde N, Farina G, Torri V, Colombo G, Piacentini G, Fotia V, Vassalli L, Pugliese P, Poletti P, Caremoli ER, Tondini C Tags: Breast Source Type: research

Risk communication in a patient decision aid for radiotherapy in breast cancer: How to deal with uncertainty?
CONCLUSIONS: We developed a novel way of visualizing uncertainties in recurrence rates in a patient decision aid. The effect of this way of communicating risk uncertainty is currently being tested in the BRASA study (NCT03375801). PMID: 32298961 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 6, 2020 Category: Cancer & Oncology Authors: Raphael DB, Russell NS, Immink JM, Westhoff PG, Stenfert Kroese MC, Stam MR, van Maurik LM, van den Bongard HJGD, Maduro JH, Sattler MGA, van der Weijden T, Boersma LJ Tags: Breast Source Type: research

Radiological audit of interval breast cancers: Estimation of tumour growth rates.
Abstract INTRODUCTION: This multicentre, retrospective study aimed to establish correlation between estimated tumour volume doubling times (TVDT) from a series of interval breast cancers with their clinicopathological features. The potential impact of delayed diagnosis on prognosis was also explored. MATERIALS AND METHODS: Interval cancers, where screening mammograms demonstrated changes that were retrospectively classified as either uncertain or suspicious, were reviewed from five screening units within the UK NHS Breast Screening Programme (NHSBSP). Data collected included the time interval between screenin...
Source: Breast - April 1, 2020 Category: Cancer & Oncology Authors: MacInnes EG, Duffy SW, Simpson JA, Wallis MG, Turnbull AE, Wilkinson LS, Satchithananda K, Rahim R, Dodwell D, Hogan BV, Blyuss O, Sharma N Tags: Breast Source Type: research

Reply letter to Leong LT.
PMID: 32279003 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 31, 2020 Category: Cancer & Oncology Authors: Girometti R, Zuiani C Tags: Breast Source Type: research

Correspondence: Preoperative assessment of breast cancer: Multireader comparison of contrast-enhanced MRI versus the combination of unenhanced MRI and digital breast tomosynthesis.
PMID: 32259673 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 31, 2020 Category: Cancer & Oncology Authors: Leong LT Tags: Breast Source Type: research

Reduced symptom burden with the support of an interactive app during neoadjuvant chemotherapy for breast cancer - A randomized controlled trial.
CONCLUSIONS: By using the Interaktor app in clinical practice, patients get individual support when managing treatment-related symptoms during neoadjuvant chemotherapy for breast cancer, leading to decreased symptom burden and improved emotional functioning. PMID: 32247251 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 20, 2020 Category: Cancer & Oncology Authors: Fjell M, Langius-Eklöf A, Nilsson M, Wengström Y, Sundberg K Tags: Breast Source Type: research

Dual HER2 blockade in the first-line treatment of metastatic breast cancer - A retrospective population-based observational study in Danish patients.
CONCLUSION: This heterogeneous patient population in a real-world setting had a PFS comparable with what could be expected from the related randomized trial. The de novo patients had better OS and PFS as compared to patients with recurrence. PMID: 32200206 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 13, 2020 Category: Cancer & Oncology Authors: Christensen T, Berg T, Nielsen LB, Andersson M, Jensen MB, Knoop A Tags: Breast Source Type: research

The survival benefit of postmastectomy radiotherapy for breast cancer patients with T1-2N1 disease according to molecular subtype.
Abstract OBJECTIVE: To evaluate the significance of postmastectomy radiotherapy (PMRT) in female breast cancer patients with T1-2N1M0 disease according to molecular subtypes and other risk factors. METHOD: We conducted a retrospective cohort-based study utilizing the Surveillance, Epidemiology, and End Results database. Patients who were diagnosed with T1-2N1M0 invasive breast cancer and received mastectomy between 2010 and 2014 were enrolled in our study. Overall survival (OS) was calculated with Kaplan-Meier method, and multivariant Cox hazard model was conducted to identify the impact of PMRT according to ...
Source: Breast - March 12, 2020 Category: Cancer & Oncology Authors: Wei J, Jiang Y, Shao Z Tags: Breast Source Type: research

Evaluation of 2014 margin guidelines on re-excision and recurrence rates after breast conserving surgery: A multi-institution retrospective study.
This study evaluates this statement in a multi-institution cohort. METHODS: A retrospective review of BCT cases at 3 comprehensive cancer centers was performed. Women age>18 receiving BCT for T1-2 breast cancer from 2008-2012 were included. Pre-2014, all sites considered 2 mm adequate. Estimated re-excision rates using the 2014 guidelines were calculated and factors predictive of re-excision were analyzed. RESULTS: 542 patients (545 lumpectomies) were eligible. Using a ≥2 mm margin standard, 32.8% of patients underwent re-excision compared to 14.1% after 2014 (p
Source: Breast - March 6, 2020 Category: Cancer & Oncology Authors: Kuritzky A, Reyna C, McGuire KP, Sun W, DeSnyder SM, Aubry S, Nayyar A, Strassle P, Hunt KK, Zhou JM, Lee MC Tags: Breast Source Type: research

Comment on: "Multidisciplinary team meeting and EUSOMA quality indicators in breast cancer care: A French regional multicenter study".
Comment on: "Multidisciplinary team meeting and EUSOMA quality indicators in breast cancer care: A French regional multicenter study". Breast. 2020 Mar 04;51:1 Authors: Ratosa I, Plavc G PMID: 32169786 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 4, 2020 Category: Cancer & Oncology Authors: Ratosa I, Plavc G Tags: Breast Source Type: research

Clinical outcome of patients with brain metastases from breast cancer - A population based study over 21 years.
CONCLUSIONS: We show an increase of BM over time whilst the time span from primary BC to BM is unchanged supports earlier findings that adjuvant treatments have little preventive function. Time from extra cranial recurrence to BM was prolonged with one year. Patients with TNBC or more advance extent of BM had the shortest survival with BM. PMID: 32145571 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - February 20, 2020 Category: Cancer & Oncology Authors: Thulin A, Rönnerman E, Zhang C, De Lara S, Chamalidou C, Schoenfeldt A, Andersson C, Kovács A, Enlund F, Linderholm B Tags: Breast Source Type: research

The impact of patient characteristics and lifestyle factors on the risk of an ipsilateral event after a primary DCIS: A systematic review.
CONCLUSION: There is a limited number of recent studies published on the impact of modifiable and non-modifiable risk factors on subsequent events after DCIS. The available evidence is insufficient to identify potential targets for risk reduction strategies, reflecting the relatively small numbers and the lack of long-term follow-up in DCIS, a low-event condition. PMID: 32120064 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - February 19, 2020 Category: Cancer & Oncology Authors: Alaeikhanehshir S, Engelhardt EG, van Duijnhoven FH, van Seijen M, Bhairosing PA, Pinto D, Collyar D, Sawyer E, Hwang SE, Thompson AM, Wesseling J, Lips EH, Schmidt MK, PRECISION Tags: Breast Source Type: research

Correspondence in response to the letter "Study validity depends on the study design and bias. Comment on "Randomised controlled trial of scalp cooling for the prevention of chemotherapy induced alopecia".
Correspondence in response to the letter "Study validity depends on the study design and bias. Comment on "Randomised controlled trial of scalp cooling for the prevention of chemotherapy induced alopecia". Breast. 2020 Feb 13;: Authors: Bajpai J, Kannan S, Gupta S PMID: 32098714 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - February 13, 2020 Category: Cancer & Oncology Authors: Bajpai J, Kannan S, Gupta S Tags: Breast Source Type: research

Machine-learned identification of psychological subgroups with relation to pain interference in patients after breast cancer treatments.
CONCLUSIONS: The results support the initial hypothesis that psychological and sleep-related parameter patterns are meaningful for subgrouping patients with respect to how persistent pain after breast cancer treatments interferes with their life. This indicates that management of pain should address more complex features than just pain intensity. Artificial intelligence is a useful tool in the identification of subgroups of patients based on psychological factors. PMID: 32066081 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - February 7, 2020 Category: Cancer & Oncology Authors: Sipilä R, Kalso E, Lötsch J Tags: Breast Source Type: research

Efficacy and safety of everolimus plus exemestane in patients with HR+, HER2- advanced breast cancer progressing on/after prior endocrine therapy in routine clinical practice: Primary results from the non-interventional study, STEPAUT.
CONCLUSIONS: Real-world safety and efficacy data from STEPAUT were consistent with results from BOLERO-2, supporting everolimus plus exemestane as a suitable treatment option for HR+, HER2- ABC recurring/progressing on/after NSAIs. PMID: 32062536 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - January 31, 2020 Category: Cancer & Oncology Authors: Steger GG, Egle D, Bartsch R, Pfeiler G, Petru E, Greil R, Helfgott R, Marth C, Öhler L, Hubalek M, Lang A, Tinchon C, Haslbauer F, Redl A, Hock K, Hennebelle M, Mraz B, Gnant M Tags: Breast Source Type: research

Study validity depends on the study design and bias. Comment on "Randomised controlled trial of scalp cooling for the prevention of chemotherapy induced alopecia" by Bajpai et  al. (The Breast. 2019 December 12. Doi: 10.1016/j.breast.2019.12.004 [Epub ahead of print]).
Study validity depends on the study design and bias. Comment on "Randomised controlled trial of scalp cooling for the prevention of chemotherapy induced alopecia" by Bajpai et al. (The Breast. 2019 December 12. Doi: 10.1016/j.breast.2019.12.004 [Epub ahead of print]). Breast. 2020 Jan 30;: Authors: Patel A PMID: 32044182 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - January 30, 2020 Category: Cancer & Oncology Authors: Patel A Tags: Breast Source Type: research

Targeted next-generation sequencing identifies genomic abnormalities potentially driving the prognosis of early-stage invasive lobular breast carcinoma patients stratified according to a validated clinico-pathological model.
ria E Abstract INTRODUCTION: The clinico-pathological and molecular factors that drive the prognosis of invasive lobular breast carcinoma (ILC) are not entirely explored. In this regard, the development and validation of a prognostic model for ILC and the investigation of the distribution of molecular abnormalities (focusing on CDK4/6 alterations) according to prognosis were the aims of this study. PATIENTS AND METHODS: Two clinico-pathological multi-center data-sets of early-stage ILC patients (Training/Validation Set, TS/VS) were gathered. A 3-class model was developed according to the multivariate analysis...
Source: Breast - January 27, 2020 Category: Cancer & Oncology Authors: Carbognin L, Simbolo M, Caliò A, Vicentini C, Delfino P, Sperduti I, Fassan M, Schettini F, Dieci MV, Griguolo G, Pilotto S, Fiorio E, Arpino G, Guarneri V, De Placido S, Conte P, Manfrin E, Brunelli M, Scambia G, Scarpa A, Tortora G, Bria E Tags: Breast Source Type: research

Improving breast cancer care coordination and symptom management by using AI driven predictive toolkits.
Abstract Integrated breast cancer care is complex, marked by multiple hand-offs between primary care and specialists over an extensive period of time. Communication is essential for treatment compliance, lowering error and complication risk, as well as handling co-morbidity. The director role of care, however, becomes often unclear, and patients remain lost across departments. Digital tools can add significant value to care communication but need clarity about the directives to perform in the care team. In effective breast cancer care, multidisciplinary team meetings can drive care planning, create directives and ...
Source: Breast - January 21, 2020 Category: Cancer & Oncology Authors: Moser EC, Narayan G Tags: Breast Source Type: research

A randomized study of olanzapine-containing versus standard antiemetic regimens for the prevention of chemotherapy-induced nausea and vomiting in Chinese breast cancer patients.
CONCLUSION: The addition of olanzapine to standard aprepitant-based antiemetic regimen provides clinically meaningful improvement in controlling CINV. This was associated with a positive impact on QOL and tolerable toxicity profiles among Chinese breast cancer patients receiving doxorubicin/cyclophosphamide chemotherapy. Further studies on metabolic profiles of breast cancer patients are warranted. PMID: 31978815 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - January 14, 2020 Category: Cancer & Oncology Authors: Yeo W, Lau TK, Li L, Lai KT, Pang E, Cheung M, Chan VT, Wong A, Soo WM, Yeung VT, Tse T, Lam DC, Yeung EW, Ng KP, Tang NL, Tong M, Suen JJ, Mo FK Tags: Breast Source Type: research

Automatic detection of perforators for microsurgical reconstruction.
so MJ Abstract The deep inferior epigastric perforator (DIEP) is the most commonly used free flap in mastectomy reconstruction. Preoperative imaging techniques are routinely used to detect location, diameter and course of perforators, with direct intervention from the imaging team, who subsequently draw a chart that will help surgeons choosing the best vascular support for the reconstruction. In this work, the feasibility of using a computer software to support the preoperative planning of 40 patients proposed for breast reconstruction with a DIEP flap is evaluated for the first time. Blood vessel centreline extra...
Source: Breast - January 12, 2020 Category: Cancer & Oncology Authors: Mavioso C, Araújo RJ, Oliveira HP, Anacleto JC, Vasconcelos MA, Pinto D, Gouveia PF, Alves C, Cardoso F, Cardoso JS, Cardoso MJ Tags: Breast Source Type: research

Second conservative treatment for second ipsilateral breast tumor event: A systematic review of the different re-irradiation techniques.
CONCLUSION: When presenting a 2ndIBTE, a SCT can safely be proposed to carefully selected and well-informed patients, as an alternative to salvage mastectomy. MIB appears to be the first intention and most robust choice. IORT, external beam radiotherapy and balloon brachytherapy are interesting alternatives but have only been tested in small series. Further investigations are required and their use should be limited to clinical trial only. PMID: 31945697 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - January 9, 2020 Category: Cancer & Oncology Authors: Montagne L, Hannoun A, Hannoun-Levi JM Tags: Breast Source Type: research

Stand-alone artificial intelligence - The future of breast cancer screening?
Abstract Although computers have had a role in interpretation of mammograms for at least two decades, their impact on performance has not lived up to expectations. However, in the last five years, the field of medical image analysis has undergone a revolution due to the introduction of deep learning convolutional neural networks - a form of artificial intelligence (AI). Because of their considerably higher performance compared to conventional computer aided detection methods, these AI algorithms have resulted in renewed interest in their potential for interpreting breast images in stand-alone mode. For this, first...
Source: Breast - January 2, 2020 Category: Cancer & Oncology Authors: Sechopoulos I, Mann RM Tags: Breast Source Type: research

Should women with early breast cancer under 40 years of age have a routine 21-gene recurrence score testing: A SEER database study.
Abstract PURPOSE: To investigate the effect of 21-gene recurrence score (RS) on chemotherapy-decision making and prognosis in breast cancer patients aged
Source: Breast - December 26, 2019 Category: Cancer & Oncology Authors: Liu KH, Zhang L, Chen JX, Lian CL, Wang J, He ZY, Wu SG Tags: Breast Source Type: research