Safety of fertility preservation in women with breast cancer.
PMID: 30293676 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - October 2, 2018 Category: Cancer & Oncology Authors: Rodriguez-Wallberg KA, Liljegren A Tags: Breast Source Type: research

Trace element concentrations in breast cancer patients.
ven J, Domingo JL Abstract Alterations in the circulating levels of trace elements have been observed in breast cancer (BC) patients. However, the relationships between these alterations and the metabolic and clinical consequences of BC are unknown. The treatment-of-choice of BC is surgery followed by radiation therapy (RT). The present study was aimed at investigating: 1) the concentrations of several trace elements in BC patients, and their relationships with the intrinsic molecular subtypes of tumors; 2) the toxicological effect of RT. We studied 49 women with BC who were scheduled to receive RT following excis...
Source: Breast - October 1, 2018 Category: Cancer & Oncology Authors: Cabré N, Luciano-Mateo F, Arenas M, Nadal M, Baiges-Gaya G, Hernández-Aguilera A, Fort-Gallifa I, Rodríguez E, Riu F, Camps J, Joven J, Domingo JL Tags: Breast Source Type: research

Treatment outcomes of breast cancer liver metastasis treated with stereotactic body radiotherapy.
CONCLUSION: This study is the first to evaluate the feasibility of SBRT to BCLM patients. Liver SBRT is a conservative approach with excellent LC and limited toxicities. PMID: 30296648 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - September 29, 2018 Category: Cancer & Oncology Authors: Onal C, Guler OC, Yildirim BA Tags: Breast Source Type: research

Risk factors of sentinel and non-sentinel lymph node metastases in patients with ductal carcinoma in situ of the breast: A nationwide study.
Abstract OBJECTIVES: Unexplained axillary metastases have been detected in some patients with ductal carcinoma in situ (DCIS), possibly because of occult invasion or iatrogenic tumor cell displacement. The significance of these metastases is unknown and brings into questions the need for upstaging and axillary surgery. What are the risk factors for sentinel lymph node (SN) and non-SN metastases, including the risk of iatrogenic displacement of tumor cells in relation to an excisional biopsy, in patients diagnosed with DCIS? METHODS: Nationwide data on 1787 women diagnosed with DCIS between 2001 and 2015 were ...
Source: Breast - September 18, 2018 Category: Cancer & Oncology Authors: Holm-Rasmussen EV, Jensen MB, Balslev E, Kroman N, Tvedskov TF Tags: Breast Source Type: research

The impact of legislation mandating breast density notification - Review of the evidence.
Abstract Breast density (BD) is an independent risk factor for breast cancer and reduces the sensitivity of mammography. The enactment of BD legislation in a majority of states in the USA mandating notification of risks associated with BD directly to women undergoing mammography has catapulted interest in BD among women, physicians, and policymakers. We therefore report a descriptive review of the evidence on the impact of enactment of BD legislation. Based on 22 eligible studies, we identified four broad themes of research: studies of the impact on screening rates, most showing increased utilisation of supplement...
Source: Breast - September 11, 2018 Category: Cancer & Oncology Authors: Houssami N, Lee CI Tags: Breast Source Type: research

Prevalence of pain in patients with breast cancer post-treatment: A systematic review.
CONCLUSION: PPBCT remains to be a prevalent and complex clinical issue, despite a variety of different techniques and treatments. Various factors such as varying definitions of pain, inconsistent use of assessment tools and differences in methodology between studies may contribute to discrepancies in reports of PPBCT. A greater understanding of BC treatments and their impact on PPBCT may help identify potential risk factors, prevention and pain management strategies. PMID: 30243159 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - September 4, 2018 Category: Cancer & Oncology Authors: Wang K, Yee C, Tam S, Drost L, Chan S, Zaki P, Rico V, Ariello K, Dasios M, Lam H, DeAngelis C, Chow E Tags: Breast Source Type: research

Expression of NY-ESO-1, MAGE-A3, PRAME and WT1 in different subgroups of breast cancer: An indication to immunotherapy?
CONCLUSIONS: This study defines a distinction between HR+ and HR-tumors through NY-ESO-1 expression. TNBC subgroup has the highest frequency of NY-ESO-1+ cases, and it could be the candidate population for the development of anti-NY-ESO-1 vaccine, both in the adjuvant or metastatic setting, and for the selection of cases suitable for immunotherapy. PMID: 30189381 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - August 29, 2018 Category: Cancer & Oncology Authors: Tessari A, Pilla L, Silvia D, Duca M, Paolini B, Carcangiu ML, Mariani L, de Braud FG, Cresta S Tags: Breast Source Type: research

Chemosensitivity, tumor infiltrating lymphocytes (TILs), and survival of postpartum PABC patients treated by neoadjuvant chemotherapy.
CONCLUSION: We observed similar patterns between postpartum PABC and control tumors in terms of chemosensitivity, immune infiltration, and prognostic. Our results enhance the idea that PP-PABC should receive the same standard of care treatment as other patients, including neoadjuvant chemotherapy. PMID: 30179779 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - August 28, 2018 Category: Cancer & Oncology Authors: Labrosse J, Abdennebi I, Thibault L, Laas E, Merckelbagh H, Morel C, Lam T, Lae M, Reyal F, Hamy AS Tags: Breast Source Type: research

Utility of short-interval follow-up mammography after a benign-concordant stereotactic breast biopsy result.
CONCLUSIONS: This study provides evidence that 6-month follow-up mammography has low clinical utility and unnecessarily increases costs after stereotactic BCBB. A safe and more cost-effective strategy may be resumption of routine mammography at 12 months post-biopsy. PMID: 30172804 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - August 23, 2018 Category: Cancer & Oncology Authors: Maldonado S, Gandhi N, Ha T, Choi P, Khalkhali I, Kalantari BN, Dauphine C Tags: Breast Source Type: research

The BCY3/BCC 2017 survey on physicians' knowledge, attitudes and practice towards fertility and pregnancy-related issues in young breast cancer patients.
CONCLUSIONS: Further educational initiatives are needed to improve physicians' knowledge and adherence to available guidelines when addressing fertility and pregnancy-related issues in young breast cancer patients. PMID: 30170202 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - August 22, 2018 Category: Cancer & Oncology Authors: Lambertini M, Di Maio M, Pagani O, Curigliano G, Poggio F, Del Mastro L, Paluch-Shimon S, Loibl S, Partridge AH, Demeestere I, Azim HA, Peccatori FA Tags: Breast Source Type: research

Therapeutic Drug Monitoring of endoxifen as an alternative for CYP2D6 genotyping in individualizing tamoxifen therapy.
The objective of this viewpoint is to highlight Therapeutic Drug Monitoring of endoxifen, the active tamoxifen metabolite, as the preferred methodology compared to CYP2D6 genotyping for individualizing tamoxifen therapy for ER-positive breast cancer patients treated in the adjuvant setting. PMID: 30153552 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - August 22, 2018 Category: Cancer & Oncology Authors: de Vries Schultink AHM, Huitema ADR, Beijnen JH Tags: Breast Source Type: research

Hypofractionation with simultaneous boost in breast cancer patients receiving adjuvant chemotherapy: A prospective evaluation of a case series and review of the literature.
CONCLUSION: Hypofractionated VMAT-SIB in patients who had undergone adjuvant systemic therapy was safe and well tolerated in terms of acute and early late settings and cosmesis. Our data confirmed the results of other studies published on the association of hypofractionation and chemotherapy or concomitant boost. PMID: 30149235 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - August 22, 2018 Category: Cancer & Oncology Authors: De Rose F, Fogliata A, Franceschini D, Iftode C, Navarria P, Comito T, Franzese C, Fernandes B, Masci G, Torrisi R, Tinterri C, Testori A, Santoro A, Scorsetti M Tags: Breast Source Type: research

Reducing harms from treatment. Sixteen years of surgery of the axilla for screen-detected breast cancers in Italy.
Abstract OBJECTIVES: Available evidence on axillary surgery has accumulated dramatically in the last two decades in favor of less invasive care. The aim of this paper is to study 16-years trends in the surgical management of the axilla in a large population-based data set of screen-detected breast cancers in Italy and to document at what extent recommendations have been adopted in actual clinical care. MATERIAL AND METHODS: This is a retrospective cohort study documenting the surgical management of the axilla in primary breast cancer patients over time. We retrieved from the Italian database of screen-detecte...
Source: Breast - August 14, 2018 Category: Cancer & Oncology Authors: Lazzaretti MG, Ponti A, Mano MP, Barca A, Casella D, Frigerio A, Giordano L, Mantellini P, Paduos A, Pitarella S, Ravaioli A, Taffurelli M, Tomatis M, Segnan N Tags: Breast Source Type: research

Local recurrence outcomes after breast conserving surgery and adjuvant radiotherapy in ductal carcinoma in situ of the breast and a comparison with ECOG E5194 study.
CONCLUSION: In our study, the 10-year local control rate was 92% and younger than 50 years old was the most important unfavorable prognostic factor for local recurrence. There was provided 20% absolute local control with adjuvant radiotherapy which eligibility criteria of ECOG 5194 high grade group. PMID: 30121548 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - August 10, 2018 Category: Cancer & Oncology Authors: Ozkaya Akagunduz O, Ergen A, Erpolat P, Gultekin M, Akkus Yildirim B, Parvizi M, Ikiz D, Colpan Oksuz D, Onal C, Yildiz F, Ozsaran Z Tags: Breast Source Type: research

Ribociclib plus letrozole and concomitant palliative radiotherapy for metastatic breast cancer.
We reported our preliminary experience on the first five patients treated at the Radiation Oncology Unit of the Florence University (Florence, Italy) giving palliative RT concomitant to ribociclib plus letrozole as first-line treatment for MBC. PMID: 30118901 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - August 9, 2018 Category: Cancer & Oncology Authors: Meattini I, Desideri I, Scotti V, Simontacchi G, Livi L Tags: Breast Source Type: research

Corrigendum to "HPV infection and breast cancer. Results of a microarray approach" [The Breast 40, (August 2018) 165-169].
Corrigendum to "HPV infection and breast cancer. Results of a microarray approach" [The Breast 40, (August 2018) 165-169]. Breast. 2018 Aug 06;41:136 Authors: Kouloura A, Nicolaidou E, Misitzis I, Panotopoulou E, Theodoraki K, Smyrniotis V, Corso G, Veronesi P, Arkadopoulos N PMID: 30092499 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - August 6, 2018 Category: Cancer & Oncology Authors: Kouloura A, Nicolaidou E, Misitzis I, Panotopoulou E, Theodoraki K, Smyrniotis V, Corso G, Veronesi P, Arkadopoulos N Tags: Breast Source Type: research

Erratum to "First-line ribociclib plus letrozole for postmenopausal women with HR+, HER2- ABC: MONALEESA-2 safety results" [Breast 36 (Suppl.  1) (November 2017) S44-S45].
Erratum to "First-line ribociclib plus letrozole for postmenopausal women with HR+, HER2- ABC: MONALEESA-2 safety results" [Breast 36 (Suppl. 1) (November 2017) S44-S45]. Breast. 2018 Aug;40:53 Authors: Janni W, Chan A, Nusch A, Alba E, Bachelot T, Gil-Gil M, Kattan J, Bourgeois H, El Karak F, Sutradhar S, Miller M, Chandiwana D, Conte P PMID: 30005916 [PubMed - in process] (Source: Breast)
Source: Breast - July 15, 2018 Category: Cancer & Oncology Authors: Janni W, Chan A, Nusch A, Alba E, Bachelot T, Gil-Gil M, Kattan J, Bourgeois H, El Karak F, Sutradhar S, Miller M, Chandiwana D, Conte P Tags: Breast Source Type: research

Omission of chemotherapy for low-grade, luminal A N1 breast cancer: Patterns of care and clinical outcomes.
Abstract PURPOSE: Multiple ongoing randomized studies are assessing the impact of omission of chemotherapy (CT) in low-risk node-positive Luminal A breast. The goal of this investigation was to evaluate trends and practice patterns of adjuvant CT use in Luminal A pT1-3N1 breast cancer, along with determining the clinical benefit from adjuvant CT in this patient population. METHODS: The National Cancer Data Base was queried (2004-2014) for women with pT1-3N1 luminal A invasive ductal carcinoma receiving adjuvant hormonal therapy (HT). Multivariable logistic regression ascertained factors associated with adjuva...
Source: Breast - July 2, 2018 Category: Cancer & Oncology Authors: Haque W, Verma V, Hatch S, Klimberg VS, Butler EB, Teh BS Tags: Breast Source Type: research

Stereotactic radiotherapy in metastatic breast cancer.
This article provides preliminary evidence that metastasis-direct ablation, with advanced radiotherapy techniques, may play an important role in the management of metastatic breast cancer patients, potentially improving clinical outcomes with minimal toxicity. However, prospective randomized controlled trials are needed to further the understanding of the interaction between systemic therapy and ablative irradiation. Additionally, research in genomic and molecular profiling is needed to characterize metastatic breast cancer patients who will most likely benefit from such combined treatment approaches. PMID: 30007269 [...
Source: Breast - June 28, 2018 Category: Cancer & Oncology Authors: Possanzini M, Greco C Tags: Breast Source Type: research

Performance of four published risk models to predict sentinel lymph-node involvement in Australian women with early breast cancer.
This study assessed the performance of four published risk models for predicting sentinel lymph-node metastasis in Australian women with early breast cancer; including one model developed in an Australian population. METHODS: The Sentinel Node Biopsy Versus Axillary Clearance (SNAC) trial dataset was used to assess model discrimination by calculating the area under the receiver-operating-characteristic curve (AUC) and the false-negative rate for sentinel lymph-node metastasis using model-predicted risk cut-points of 10%, 20%, 30%, and calibration using Hosmer-Lemeshow tests and calibration plots. RESULTS: The sen...
Source: Breast - June 26, 2018 Category: Cancer & Oncology Authors: Elmadahm A, Lord SJ, Hudson HM, Lee CK, Buizen L, Farshid G, Gebski VJ, Gill PG Tags: Breast Source Type: research

Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines.
Abstract Studies have emphasized an antineoplastic effect of the non-psychoactive, phyto-cannabinoid, Cannabidiol (CBD). However, the molecular mechanism underlying its antitumor activity is not fully elucidated. Herein, we have examined the effect of CBD on two different human breast cancer cell lines: the ER-positive, well differentiated, T-47D and the triple negative, poor differentiated, MDA-MB-231 cells. In both cell lines, CBD inhibited cell survival and induced apoptosis in a dose dependent manner as observed by MTT assay, morphological changes, DNA fragmentation and ELISA apoptosis assay. CBD-induced apo...
Source: Breast - June 22, 2018 Category: Cancer & Oncology Authors: Sultan AS, Marie MA, Sheweita SA Tags: Breast Source Type: research

Link between estrogen deficiency osteoporosis and susceptibility to bone metastases: A way towards precision medicine in cancer patients.
Abstract Different fields of cancer management consider bone health to be of increasing clinical importance for patients: 1) presence of bone metastases in many solid tumors, 2) use of bone-targeted treatments in the reduction of bone metastasis, 3) effects of cancer treatment on reproductive hormones, critical for normal bone remodeling maintenance. Additionally, bone microenvironment is further complicated by the decline of ovarian sex steroid production and by the related increase in inflammatory factors linked to menopause, which result in accelerated bone loss and increased risk of osteoporosis (OP). Similarl...
Source: Breast - June 22, 2018 Category: Cancer & Oncology Authors: Salamanna F, Borsari V, Contartese D, Nicoli Aldini N, Fini M Tags: Breast Source Type: research

Prospective study to optimize care and improve knowledge on ovarian function and/or fertility preservation in young breast cancer patients: Results of the pilot phase of the PREgnancy and FERtility (PREFER) study.
CONCLUSION: Despite the majority of young breast cancer patients are concerned about the risk of treatment-induced POI and/or infertility, only a limited number of them required to access the fertility unit to undergo cryopreservation strategies. PMID: 30007268 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 22, 2018 Category: Cancer & Oncology Authors: Lambertini M, Fontana V, Massarotti C, Poggio F, Dellepiane C, Iacono G, Abate A, Miglietta L, Ferreccio C, Pescio MC, Conte B, Blondeaux E, Bighin C, D'Alonzo A, Vaglica M, Zanardi E, Boccardo F, Ballestrero A, Anserini P, Del Mastro L Tags: Breast Source Type: research

Quality of life evolution in elderly survivors with localized breast cancer treated with radiotherapy over a three-year follow-up.
nez E Abstract PURPOSE: This paper studies the Quality of Life (QL) of elderly early-stage breast cancer survivors. The aims are to compare the QL scores of these patients after follow-up with their scores before the start of radiotherapy (RT) and compare QL among different axillary treatment groups. METHODS: Of 173 patients over 65 who began treatment and completed the EORTC QLQ-C30 and QLQ-BR23 and the Interview for Deterioration in Daily Living Activities in Dementia (IDDD) before RT, 138 also completed these questionnaires three years after RT. Longitudinal changes in QL were assessed for the whole sample...
Source: Breast - June 22, 2018 Category: Cancer & Oncology Authors: Arraras JI, Manterola A, Illarramendi JJ, Asin G, de la Cruz S, Ibañez B, Galbete A, Salgado E, Zarandona U, Vera R, Dominguez MA, Martinez E Tags: Breast Source Type: research

The impact of organized breast assessment on survival by stage for screened women diagnosed with invasive breast cancer.
CONCLUSION: The significant improvement in overall survival for women with stage I screen-detected invasive breast cancer assessed through BACs further supports the recommendation that women with abnormal mammograms should be managed through organized assessment. PMID: 29957557 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 18, 2018 Category: Cancer & Oncology Authors: Smith CR, Chiarelli AM, Holloway CM, Mirea L, O'Malley FP, Blackmore KM, Pandya A, Majpruz V, Harris CP, Hendry A, Hey A, Kornecki A, Lougheed G, Maier BA, Marchand P, McCready D, Rand C, Raphael S, Segal-Nadler R, Sehgal N, Muradali D Tags: Breast Source Type: research

The value of 3D images in the aesthetic evaluation of breast cancer conservative treatment. Results from a prospective multicentric clinical trial.
CONCLUSIONS: The inclusion of 3D images did not add significant information to the aesthetic evaluation either by the panel or the software. Evaluation of aesthetic outcome can be performed using of the BCCT.core software, with a single frontal image. PMID: 29940498 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 18, 2018 Category: Cancer & Oncology Authors: Cardoso MJ, Vrieling C, Cardoso JS, Oliveira HP, Williams NR, Dixon JM, PICTURE Project Clinical Trial Team, PICTURE Project Delphi Panel Tags: Breast Source Type: research

Fluctuation of the left ventricular ejection fraction in patients with HER2-positive early breast cancer treated by 12 months of adjuvant trastuzumab.
CONCLUSION: The LVEF decreased during treatment with trastuzumab and rose up after the completion of treatment without coming back to the initial values for a substantial subset. These results would suggest investigating some strategies aimed to improve the ability to achieve a full recovery. PMID: 29913374 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 15, 2018 Category: Cancer & Oncology Authors: Jacquinot Q, Paget-Bailly S, Fumoleau P, Romieu G, Pierga JY, Espié M, Lortholary A, Nabholtz JM, Mercier CF, Pauporté I, Henriques J, Pivot X Tags: Breast Source Type: research

Group medical consultations (GMCs) and tablet-based online support group sessions in the follow-up of breast cancer: A multicenter randomized controlled trial.
CONCLUSIONS: My-GMC did not result in improvements in distress or empowerment, which might partly be explained by low baseline distress levels. This paper provides valuable information concerning factors on organizational level as well as individual level influencing the evaluation of a blended care intervention. PRACTICE IMPLICATIONS: My-GMC provided an innovative alternative, combining professional and peer-support in face-to-face and online SGS, resulting in additional information provision and peer-support. Further improvement of the apps is needed to improve user satisfaction. NETHERLANDS TRIAL REGISTER: NTR...
Source: Breast - June 12, 2018 Category: Cancer & Oncology Authors: Visser A, Prins JB, Jansen L, Radema SA, Schlooz MS, van Dalen T, van Laarhoven HWM Tags: Breast Source Type: research

Impact of schizophrenia and related disorders on mortality from breast cancer: A population-based cohort study in Denmark, 1995-2011.
CONCLUSION: The survival of women with schizophrenia or related disorders after breast cancer is significantly worse than that of women without these disorders. These patients are less likely to be allocated to guideline treatment, and, among those who are, mortality from both breast cancer and other causes is increased. PMID: 29902718 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 11, 2018 Category: Cancer & Oncology Authors: Dalton SO, Suppli NP, Ewertz M, Kroman N, Grassi L, Johansen C Tags: Breast Source Type: research

HPV infection and breast cancer. Results of a microarray approach.
CONCLUSION: In the present study, a combination of careful sample collection and a very sensitive microarray approach showed no correlation between HPV and breast cancer. However some characteristics of the breast tumors were different among patients with HPV DNA in their cervical samples. PMID: 29890463 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - June 4, 2018 Category: Cancer & Oncology Authors: Kouloura A, Nicolaidou E, Misitzis I, Panotopoulou E, Smyrniotis V, Corso G, Veroneci P, Arkadopoulos N Tags: Breast Source Type: research

Reply to 'A standard mastectomy should not be the only recommended breast surgical treatment for non-metastatic inflammatory breast cancer: A large population-based study in the Surveillance, Epidemiology, and End Results database 18'.
PMID: 29729725 [PubMed - in process] (Source: Breast)
Source: Breast - May 9, 2018 Category: Cancer & Oncology Authors: Woodward WA, Ueno NT, Kuerer HM, Lucci A, Shen Y Tags: Breast Source Type: research

Assessing the effectiveness of interventions to support patient decision making about breast reconstruction: A systematic review.
CONCLUSIONS: Few interventions are currently available. Whilst some findings are encouraging, improvements on patient outcomes are mixed. Further research should focus on the development and evaluation of effective interventions. PMID: 29730304 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - May 3, 2018 Category: Cancer & Oncology Authors: Paraskeva N, Guest E, Lewis-Smith H, Harcourt D Tags: Breast Source Type: research

An exploratory radiomics analysis on digital breast tomosynthesis in women with mammographically negative dense breasts.
CONCLUSION: Radiomics features in patients with dense breasts and negative mammography appear to differ between cancerous and normal breast tissue, with evidence of correlation with tumor size and estrogen receptors. This new information warrants further evaluation in larger studies and could contribute to improved understanding of breast cancer through imaging, and may support tailored screening and treatments. PMID: 29723697 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 30, 2018 Category: Cancer & Oncology Authors: Tagliafico AS, Valdora F, Mariscotti G, Durando M, Nori J, La Forgia D, Rosenberg I, Caumo F, Gandolfo N, Houssami N, Calabrese M Tags: Breast Source Type: research

Patterns of disease progression in patients with local and metastatic breast cancer as evaluated by whole-body magnetic resonance imaging.
CONCLUSION: Clinical evidence of SACT benefit in local disease may give false reassurance about disease at metastatic sites. PMID: 29709728 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 27, 2018 Category: Cancer & Oncology Authors: Kosmin M, Padhani AR, Sokhi H, Thijssen T, Makris A Tags: Breast Source Type: research

Smoking and FGFR2 rs2981582 variant independently modulate male breast cancer survival: A population-based study in Tuscany, Italy.
CONCLUSIONS: Our results may contribute to shed light on factors influencing MBC survival suggesting an important role for cigarette smoking and FGFR2 rs2981582 variant, and provide clues for better patient management. PMID: 29709729 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 27, 2018 Category: Cancer & Oncology Authors: Zanna I, Silvestri V, Palli D, Magrini A, Rizzolo P, Saieva C, Zelli V, Bendinelli B, Vezzosi V, Valentini V, Bianchi S, Ottini L, Masala G Tags: Breast Source Type: research

Highly significant improvement in guideline adherence, relapse-free and overall survival in breast cancer patients when treated at certified breast cancer centres: An evaluation of 8323 patients.
CONCLUSION: A highly significant (p 
Source: Breast - April 23, 2018 Category: Cancer & Oncology Authors: Kreienberg R, Wöckel A, Wischnewsky M Tags: Breast Source Type: research

Outcomes of systemic therapy for advanced triple-negative breast cancer: A single centre experience.
CONCLUSIONS: The observed response rates are consistent with literature. However, PFS is short, and early consideration of clinical trials can be justified in these patients. PMID: 29698926 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 23, 2018 Category: Cancer & Oncology Authors: Battisti NML, Okonji D, Manickavasagar T, Mohammed K, Allen M, Ring A Tags: Breast Source Type: research

A randomized phase II trial of trastuzumab plus capecitabine versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer previously treated with trastuzumab and taxanes: WJOG6110B/ELTOP.
CONCLUSION: In women with HER2-positive MBC previously treated with trastuzumab and taxanes, no significant differences in PFS and OS were observed between patients treated with LX and HX. TRIAL REGISTRATION NUMBER: UMIN000005219. PMID: 29698927 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 23, 2018 Category: Cancer & Oncology Authors: Takano T, Tsurutani J, Takahashi M, Yamanaka T, Sakai K, Ito Y, Fukuoka J, Kimura H, Kawabata H, Tamura K, Matsumoto K, Aogi K, Sato K, Nishio K, Nakagawa K, Saeki T Tags: Breast Source Type: research

Identifying pathologic complete response of the breast after neoadjuvant systemic therapy with ultrasound guided biopsy to eventually omit surgery: Study design and feasibility of the MICRA trial (Minimally Invasive Complete Response Assessment).
CONCLUSION: Ultrasound guided biopsy of the breast in patients with excellent response on MRI after NST is feasible. Accuracy results of the MICRA trial will be presented after inclusion of 525 patients to determine if ultrasound guided biopsy is an accurate alternative to surgical resection for assessment of pCR after NST. PMID: 29698928 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 23, 2018 Category: Cancer & Oncology Authors: van der Noordaa MEM, van Duijnhoven FH, Loo CE, van Werkhoven E, van de Vijver KK, Wiersma T, Winter-Warnars HAO, Sonke GS, Vrancken Peeters MTFD Tags: Breast Source Type: research

Global analysis of advanced/metastatic breast cancer: Decade report (2005-2015).
Abstract Approximately 0.5 million people worldwide die from metastatic breast cancer (mBC) every year. This manuscript provides an overview on the status of mBC in several regions of the world, highlighting the gaps in care, resources, and support available for patients with mBC. Primary research was conducted in 2015 and 2016, comprising four global qualitative and quantitative surveys of approximately 15,000 individuals in 34 countries. Secondary research was conducted using literature reviews of peer-reviewed publications, patient survey reports, and media or online articles. There have been modest improvement...
Source: Breast - April 18, 2018 Category: Cancer & Oncology Authors: Cardoso F, Spence D, Mertz S, Corneliussen-James D, Sabelko K, Gralow J, Cardoso MJ, Peccatori F, Paonessa D, Benares A, Sakurai N, Beishon M, Barker SJ, Mayer M Tags: Breast Source Type: research

Controversies in monitoring metastatic breast cancer during systemic treatment. Results of a GIM (Gruppo Italiano Mammella) survey.
CONCLUSION: M-MBC strategy still has controversial issues and its potential clinical effects for breast cancer patients need ad hoc studies. PMID: 29679936 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 18, 2018 Category: Cancer & Oncology Authors: Marta B, Debora B, Lorenzo G, Giacomo P, Michele B, Grazia VM, Valentina F, Camilla L, Mauro M, Marco MA, Giuseppe A, Michele L, Filippo M, Lucia DM, Fabio P Tags: Breast Source Type: research

Validation of the CPS+EG and Neo-Bioscore staging systems after preoperative systemic therapy for breast cancer in a single center in China.
Abstract BACKGROUND: Prognostic assessment after preoperative systemic therapy (PST) plays a vital role in determining treatment in breast cancer patients. Many researchers have sought to develop a system to quantitate residual tumor and its correlation with prognosis after PST. This retrospective study validated the CPS + EG staging system and Neo-Bioscore in a single center in China. METHODS: Data from patients with non-metastatic primary breast cancer who were treated with PST and surgery from Jan. 2008 to Dec. 2014 at the Breast Disease Center of Peking University First Hospital, China, were r...
Source: Breast - April 17, 2018 Category: Cancer & Oncology Authors: Xu L, Duan X, Zhou B, Liu Y, Ye J, Liu Z, Ma C, Zhang H, Zhang S, Zhang L, Zhao J, Cheng Y Tags: Breast Source Type: research

Validation of the AJCC 8th prognostic system for breast cancer in an Asian healthcare setting.
CONCLUSION: The prognostic staging system was better than the anatomic staging system in predicting outcomes but the anatomic system remains relevant due to its ease of use. PMID: 29677569 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 17, 2018 Category: Cancer & Oncology Authors: Wong RX, Wong FY, Lim J, Lian WX, Yap YS Tags: Breast Source Type: research

One-step intraoperative radiotherapy optimizes conservative treatment of breast cancer with advantages in quality of life and work resumption.
Abstract BACKGROUND: Intraoperative radiotherapy (IORT) could be not-inferior to external beam radiotherapy (EBRT) in selected patients, but toxicities, self-perception of body image, quality of life, and resumption of work or daily activities have been poorly explored. The aim of the present study was to compare these outcomes between EBRT, IORT full-dose (IORT-f) and IORT boost (IORT-b). METHODS: 443 consecutive patients, candidates for breast-conserving surgery, were included: EBRT was performed in 220 patients (49.7%), IORT-f in 140 patients (31.6%), and IORT-b in 83 patients (18.7%). Radiotherapy-related...
Source: Breast - April 16, 2018 Category: Cancer & Oncology Authors: Sorrentino L, Fissi S, Meaglia I, Bossi D, Caserini O, Mazzucchelli S, Truffi M, Albasini S, Tabarelli P, Liotta M, Ivaldi GB, Corsi F Tags: Breast Source Type: research

Childbearing across borders: Fertility and parenthood attitudes and decisions among breast cancer survivors in USA and Portugal.
nn GP Abstract OBJECTIVE: To compare fertility and childbearing attitudes and decisions of Portuguese and American female reproductive aged breast cancer survivors. METHODS: This was a cross-sectional study of 102 young breast cancer survivors (59 from Portugal and 43 from USA). Demographic, clinical and reproductive information were collected. Fertility and parenthood attitudes and decisions were assessed through a self-report questionnaire devised specifically for the study. RESULTS: Fertility issues became very important after the diagnosis for most of the women (51%). Few differences existed between ...
Source: Breast - April 16, 2018 Category: Cancer & Oncology Authors: Gonçalves V, Hudson J, Canavarro MC, Morris J, Lee MC, Donovan KA, Sutton SK, Vadaparampil ST, Quinn GP Tags: Breast Source Type: research

Physical activity levels after treatment for breast cancer: Two-year follow-up.
CONCLUSIONS: Two years after breast cancer surgery, physical activity levels are still significantly lower compared to pre-operative values. Based on this limited recovery, it seems important to monitor physical activity levels in breast cancer patients and advice these patients to stay active after surgery and return to pre-operative activity levels in the long term as well. This study indicates the importance of long term monitoring and subsequently coaching of physical activity after breast cancer surgery. PMID: 29674221 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 16, 2018 Category: Cancer & Oncology Authors: De Groef A, Geraerts I, Demeyer H, Van der Gucht E, Dams L, de Kinkelder C, Dukers-van Althuis S, Van Kampen M, Devoogdt N Tags: Breast Source Type: research

Propensity score to evaluate prognosis in pregnancy-associated breast cancer: Analysis from a French cancer network.
CONCLUSIONS: After PSM for known prognostic factors, the prognosis of BCP patients did not differ from that of young patients with non-BCP. PMID: 29665447 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 14, 2018 Category: Cancer & Oncology Authors: Boudy AS, Naoura I, Selleret L, Zilberman S, Gligorov J, Richard S, Thomassin-Naggara I, Chabbert-Buffet N, Ballester M, Bendifallah S, Darai E Tags: Breast Source Type: research

All pure flat atypical atypia lesions of the breast diagnosed using percutaneous vacuum-assisted breast biopsy do not need surgical excision.
CONCLUSION: This study included 70 cases of pure FEA. Twenty women underwent surgical excision and 50 had clinical and mammographic surveillance only. In three women FEA was upgraded to breast cancer on excision. Clinical and mammographic follow-up for a mean of 56 months ± 27 in the group without excision showed two cancers in the same breast (Intermediate grade DCIS, and invasive ductal carcinoma 84 and 48 months respectively after VABB). Three factors were significantly predictive of underestimation or occurence of cancer for pure FEA when the radiologic lesions are calcifications: age≥ 57 years, radiologi...
Source: Breast - April 14, 2018 Category: Cancer & Oncology Authors: Ouldamer L, Poisson E, Arbion F, Bonneau C, Vildé A, Body G, Michenet P Tags: Breast Source Type: research

Scalp cooling successfully prevents alopecia in breast cancer patients undergoing anthracycline/taxane-based chemotherapy.
This study assesses whether a scalp-cooling device is effective in reducing chemotherapy-induced alopecia, and assesses adverse treatment effects. MATERIALS AND METHODS: A prospective observational study including women with breast cancer undergoing chemotherapy and scalp cooling using a Paxman device. The primary efficacy end points were: successful hair preservation (no hair loss;
Source: Breast - April 13, 2018 Category: Cancer & Oncology Authors: Vasconcelos I, Wiesske A, Schoenegg W Tags: Breast Source Type: research

Dosage-dependent reduction of macular pigment optical density in female breast cancer patients receiving tamoxifen adjuvant therapy.
Abstract It is now increasingly common for breast cancer patients to receive adjuvant tamoxifen therapy for a period of up to 10 years. As survival rate increases, managing tamoxifen ocular toxicities is important for patients' quality of life. Macular pigments in photoreceptor cells protect against free radical damage, which can cause macular degeneration. By reducing macular pigment concentration, tamoxifen may increase the risk of macular degeneration. Here, we compared macular pigment optical density (MPOD) and central macular thickness between breast cancer patients on tamoxifen adjuvant therapy (n = 70),...
Source: Breast - April 13, 2018 Category: Cancer & Oncology Authors: Lim IL, Loo AVP, Subrayan V, Khang TF, See MH, Alip A, Taib NAM Tags: Breast Source Type: research