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Reply to 'A standard mastectomy should not be the only recommended breast surgical treatment for non-metastatic inflammatory breast cancer: A large population-based study in the Surveillance, Epidemiology, and End Results database 18'.
PMID: 29729725 [PubMed - in process] (Source: Breast)
Source: Breast - May 9, 2018 Category: Cancer & Oncology Authors: Woodward WA, Ueno NT, Kuerer HM, Lucci A, Shen Y Tags: Breast Source Type: research

Assessing the effectiveness of interventions to support patient decision making about breast reconstruction: A systematic review.
CONCLUSIONS: Few interventions are currently available. Whilst some findings are encouraging, improvements on patient outcomes are mixed. Further research should focus on the development and evaluation of effective interventions. PMID: 29730304 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - May 3, 2018 Category: Cancer & Oncology Authors: Paraskeva N, Guest E, Lewis-Smith H, Harcourt D Tags: Breast Source Type: research

An exploratory radiomics analysis on digital breast tomosynthesis in women with mammographically negative dense breasts.
CONCLUSION: Radiomics features in patients with dense breasts and negative mammography appear to differ between cancerous and normal breast tissue, with evidence of correlation with tumor size and estrogen receptors. This new information warrants further evaluation in larger studies and could contribute to improved understanding of breast cancer through imaging, and may support tailored screening and treatments. PMID: 29723697 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 30, 2018 Category: Cancer & Oncology Authors: Tagliafico AS, Valdora F, Mariscotti G, Durando M, Nori J, La Forgia D, Rosenberg I, Caumo F, Gandolfo N, Houssami N, Calabrese M Tags: Breast Source Type: research

Patterns of disease progression in patients with local and metastatic breast cancer as evaluated by whole-body magnetic resonance imaging.
CONCLUSION: Clinical evidence of SACT benefit in local disease may give false reassurance about disease at metastatic sites. PMID: 29709728 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 27, 2018 Category: Cancer & Oncology Authors: Kosmin M, Padhani AR, Sokhi H, Thijssen T, Makris A Tags: Breast Source Type: research

Smoking and FGFR2 rs2981582 variant independently modulate male breast cancer survival: A population-based study in Tuscany, Italy.
CONCLUSIONS: Our results may contribute to shed light on factors influencing MBC survival suggesting an important role for cigarette smoking and FGFR2 rs2981582 variant, and provide clues for better patient management. PMID: 29709729 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 27, 2018 Category: Cancer & Oncology Authors: Zanna I, Silvestri V, Palli D, Magrini A, Rizzolo P, Saieva C, Zelli V, Bendinelli B, Vezzosi V, Valentini V, Bianchi S, Ottini L, Masala G Tags: Breast Source Type: research

Highly significant improvement in guideline adherence, relapse-free and overall survival in breast cancer patients when treated at certified breast cancer centres: An evaluation of 8323 patients.
CONCLUSION: A highly significant (p 
Source: Breast - April 23, 2018 Category: Cancer & Oncology Authors: Kreienberg R, Wöckel A, Wischnewsky M Tags: Breast Source Type: research

Outcomes of systemic therapy for advanced triple-negative breast cancer: A single centre experience.
CONCLUSIONS: The observed response rates are consistent with literature. However, PFS is short, and early consideration of clinical trials can be justified in these patients. PMID: 29698926 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 23, 2018 Category: Cancer & Oncology Authors: Battisti NML, Okonji D, Manickavasagar T, Mohammed K, Allen M, Ring A Tags: Breast Source Type: research

A randomized phase II trial of trastuzumab plus capecitabine versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer previously treated with trastuzumab and taxanes: WJOG6110B/ELTOP.
CONCLUSION: In women with HER2-positive MBC previously treated with trastuzumab and taxanes, no significant differences in PFS and OS were observed between patients treated with LX and HX. TRIAL REGISTRATION NUMBER: UMIN000005219. PMID: 29698927 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 23, 2018 Category: Cancer & Oncology Authors: Takano T, Tsurutani J, Takahashi M, Yamanaka T, Sakai K, Ito Y, Fukuoka J, Kimura H, Kawabata H, Tamura K, Matsumoto K, Aogi K, Sato K, Nishio K, Nakagawa K, Saeki T Tags: Breast Source Type: research

Identifying pathologic complete response of the breast after neoadjuvant systemic therapy with ultrasound guided biopsy to eventually omit surgery: Study design and feasibility of the MICRA trial (Minimally Invasive Complete Response Assessment).
CONCLUSION: Ultrasound guided biopsy of the breast in patients with excellent response on MRI after NST is feasible. Accuracy results of the MICRA trial will be presented after inclusion of 525 patients to determine if ultrasound guided biopsy is an accurate alternative to surgical resection for assessment of pCR after NST. PMID: 29698928 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 23, 2018 Category: Cancer & Oncology Authors: van der Noordaa MEM, van Duijnhoven FH, Loo CE, van Werkhoven E, van de Vijver KK, Wiersma T, Winter-Warnars HAO, Sonke GS, Vrancken Peeters MTFD Tags: Breast Source Type: research

Global analysis of advanced/metastatic breast cancer: Decade report (2005-2015).
Abstract Approximately 0.5 million people worldwide die from metastatic breast cancer (mBC) every year. This manuscript provides an overview on the status of mBC in several regions of the world, highlighting the gaps in care, resources, and support available for patients with mBC. Primary research was conducted in 2015 and 2016, comprising four global qualitative and quantitative surveys of approximately 15,000 individuals in 34 countries. Secondary research was conducted using literature reviews of peer-reviewed publications, patient survey reports, and media or online articles. There have been modest improvement...
Source: Breast - April 18, 2018 Category: Cancer & Oncology Authors: Cardoso F, Spence D, Mertz S, Corneliussen-James D, Sabelko K, Gralow J, Cardoso MJ, Peccatori F, Paonessa D, Benares A, Sakurai N, Beishon M, Barker SJ, Mayer M Tags: Breast Source Type: research

Controversies in monitoring metastatic breast cancer during systemic treatment. Results of a GIM (Gruppo Italiano Mammella) survey.
CONCLUSION: M-MBC strategy still has controversial issues and its potential clinical effects for breast cancer patients need ad hoc studies. PMID: 29679936 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 18, 2018 Category: Cancer & Oncology Authors: Marta B, Debora B, Lorenzo G, Giacomo P, Michele B, Grazia VM, Valentina F, Camilla L, Mauro M, Marco MA, Giuseppe A, Michele L, Filippo M, Lucia DM, Fabio P Tags: Breast Source Type: research

Validation of the CPS+EG and Neo-Bioscore staging systems after preoperative systemic therapy for breast cancer in a single center in China.
Abstract BACKGROUND: Prognostic assessment after preoperative systemic therapy (PST) plays a vital role in determining treatment in breast cancer patients. Many researchers have sought to develop a system to quantitate residual tumor and its correlation with prognosis after PST. This retrospective study validated the CPS + EG staging system and Neo-Bioscore in a single center in China. METHODS: Data from patients with non-metastatic primary breast cancer who were treated with PST and surgery from Jan. 2008 to Dec. 2014 at the Breast Disease Center of Peking University First Hospital, China, were r...
Source: Breast - April 17, 2018 Category: Cancer & Oncology Authors: Xu L, Duan X, Zhou B, Liu Y, Ye J, Liu Z, Ma C, Zhang H, Zhang S, Zhang L, Zhao J, Cheng Y Tags: Breast Source Type: research

Validation of the AJCC 8th prognostic system for breast cancer in an Asian healthcare setting.
CONCLUSION: The prognostic staging system was better than the anatomic staging system in predicting outcomes but the anatomic system remains relevant due to its ease of use. PMID: 29677569 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 17, 2018 Category: Cancer & Oncology Authors: Wong RX, Wong FY, Lim J, Lian WX, Yap YS Tags: Breast Source Type: research

One-step intraoperative radiotherapy optimizes conservative treatment of breast cancer with advantages in quality of life and work resumption.
Abstract BACKGROUND: Intraoperative radiotherapy (IORT) could be not-inferior to external beam radiotherapy (EBRT) in selected patients, but toxicities, self-perception of body image, quality of life, and resumption of work or daily activities have been poorly explored. The aim of the present study was to compare these outcomes between EBRT, IORT full-dose (IORT-f) and IORT boost (IORT-b). METHODS: 443 consecutive patients, candidates for breast-conserving surgery, were included: EBRT was performed in 220 patients (49.7%), IORT-f in 140 patients (31.6%), and IORT-b in 83 patients (18.7%). Radiotherapy-related...
Source: Breast - April 16, 2018 Category: Cancer & Oncology Authors: Sorrentino L, Fissi S, Meaglia I, Bossi D, Caserini O, Mazzucchelli S, Truffi M, Albasini S, Tabarelli P, Liotta M, Ivaldi GB, Corsi F Tags: Breast Source Type: research

Childbearing across borders: Fertility and parenthood attitudes and decisions among breast cancer survivors in USA and Portugal.
nn GP Abstract OBJECTIVE: To compare fertility and childbearing attitudes and decisions of Portuguese and American female reproductive aged breast cancer survivors. METHODS: This was a cross-sectional study of 102 young breast cancer survivors (59 from Portugal and 43 from USA). Demographic, clinical and reproductive information were collected. Fertility and parenthood attitudes and decisions were assessed through a self-report questionnaire devised specifically for the study. RESULTS: Fertility issues became very important after the diagnosis for most of the women (51%). Few differences existed between ...
Source: Breast - April 16, 2018 Category: Cancer & Oncology Authors: Gonçalves V, Hudson J, Canavarro MC, Morris J, Lee MC, Donovan KA, Sutton SK, Vadaparampil ST, Quinn GP Tags: Breast Source Type: research

Physical activity levels after treatment for breast cancer: Two-year follow-up.
CONCLUSIONS: Two years after breast cancer surgery, physical activity levels are still significantly lower compared to pre-operative values. Based on this limited recovery, it seems important to monitor physical activity levels in breast cancer patients and advice these patients to stay active after surgery and return to pre-operative activity levels in the long term as well. This study indicates the importance of long term monitoring and subsequently coaching of physical activity after breast cancer surgery. PMID: 29674221 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 16, 2018 Category: Cancer & Oncology Authors: De Groef A, Geraerts I, Demeyer H, Van der Gucht E, Dams L, de Kinkelder C, Dukers-van Althuis S, Van Kampen M, Devoogdt N Tags: Breast Source Type: research

Propensity score to evaluate prognosis in pregnancy-associated breast cancer: Analysis from a French cancer network.
CONCLUSIONS: After PSM for known prognostic factors, the prognosis of BCP patients did not differ from that of young patients with non-BCP. PMID: 29665447 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 14, 2018 Category: Cancer & Oncology Authors: Boudy AS, Naoura I, Selleret L, Zilberman S, Gligorov J, Richard S, Thomassin-Naggara I, Chabbert-Buffet N, Ballester M, Bendifallah S, Darai E Tags: Breast Source Type: research

All pure flat atypical atypia lesions of the breast diagnosed using percutaneous vacuum-assisted breast biopsy do not need surgical excision.
CONCLUSION: This study included 70 cases of pure FEA. Twenty women underwent surgical excision and 50 had clinical and mammographic surveillance only. In three women FEA was upgraded to breast cancer on excision. Clinical and mammographic follow-up for a mean of 56 months ± 27 in the group without excision showed two cancers in the same breast (Intermediate grade DCIS, and invasive ductal carcinoma 84 and 48 months respectively after VABB). Three factors were significantly predictive of underestimation or occurence of cancer for pure FEA when the radiologic lesions are calcifications: age≥ 57 years, radiologi...
Source: Breast - April 14, 2018 Category: Cancer & Oncology Authors: Ouldamer L, Poisson E, Arbion F, Bonneau C, Vildé A, Body G, Michenet P Tags: Breast Source Type: research

Scalp cooling successfully prevents alopecia in breast cancer patients undergoing anthracycline/taxane-based chemotherapy.
This study assesses whether a scalp-cooling device is effective in reducing chemotherapy-induced alopecia, and assesses adverse treatment effects. MATERIALS AND METHODS: A prospective observational study including women with breast cancer undergoing chemotherapy and scalp cooling using a Paxman device. The primary efficacy end points were: successful hair preservation (no hair loss;
Source: Breast - April 13, 2018 Category: Cancer & Oncology Authors: Vasconcelos I, Wiesske A, Schoenegg W Tags: Breast Source Type: research

Dosage-dependent reduction of macular pigment optical density in female breast cancer patients receiving tamoxifen adjuvant therapy.
Abstract It is now increasingly common for breast cancer patients to receive adjuvant tamoxifen therapy for a period of up to 10 years. As survival rate increases, managing tamoxifen ocular toxicities is important for patients' quality of life. Macular pigments in photoreceptor cells protect against free radical damage, which can cause macular degeneration. By reducing macular pigment concentration, tamoxifen may increase the risk of macular degeneration. Here, we compared macular pigment optical density (MPOD) and central macular thickness between breast cancer patients on tamoxifen adjuvant therapy (n = 70),...
Source: Breast - April 13, 2018 Category: Cancer & Oncology Authors: Lim IL, Loo AVP, Subrayan V, Khang TF, See MH, Alip A, Taib NAM Tags: Breast Source Type: research

Prolactin Induced Protein (PIP) is a potential biomarker for early stage and malignant breast cancer.
The objective of this investigation was to characterize the expression pattern of PIP, an aspartyl proteinase, in malignant and non-malignant breast tissues. MATERIALS AND METHODS: Real time quantitative PCR was employed to analyze PIP and androgen receptor (AR) mRNA levels in BC cell lines and 190 normal tissues and tumor samples. The tumor specimens were categorized based on TNM classification, anatomic stage, histologic grade and molecular subtype and expression pattern evaluated. To detect protein levels, immunohistochemistry followed by semi quantitative scoring was employed in the examination of 517 normal, beni...
Source: Breast - April 12, 2018 Category: Cancer & Oncology Authors: Gangadharan A, Nyirenda T, Patel K, Jaimes-Delgadillo N, Coletta D, Tanaka T, Walland AC, Jameel Z, Vedantam S, Tang S, Mannion C, Lee GY, Goy A, Pecora A, Suh KS Tags: Breast Source Type: research

Delay of adjuvant radiotherapy due to postoperative complications after oncoplastic breast conserving surgery.
CONCLUSION: This study provides a detailed overview of the used techniques of oncoplastic BCS and their postoperative complications. Most complications occurred before the start of the adjuvant radiotherapy. Just a small amount caused a delay for the radiotherapy to start. PMID: 29656223 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 12, 2018 Category: Cancer & Oncology Authors: Hillberg NS, Meesters-Caberg MAJ, Beugels J, Winkens B, Vissers YLJ, van Mulken TJM Tags: Breast Source Type: research

Valid assessment of women's satisfaction with breast cancer screening programs.
PMID: 29655903 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 11, 2018 Category: Cancer & Oncology Authors: Bairati I Tags: Breast Source Type: research

Underdiagnosed and disfiguring - Radiation-induced morphea following breast cancer treatment.
CONCLUSIONS: Unfortunately, there are no known predictors for RIM. Early recognition by the oncologist, the breast surgeon or the reconstructive surgeon during follow-up enables expeditious provision of patient reassurance and helps guide potential treatment options. PMID: 29635112 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 7, 2018 Category: Cancer & Oncology Authors: Friedman O, Barnea Y, Hafner A Tags: Breast Source Type: research

HER2-positive breast cancer: Current and new therapeutic strategies.
Bellet M, Saura C Abstract Since the identification of the HER2 receptor amplification as an adverse prognostic factor that defined a special subtype of metastatic breast cancer, there has been a substantial improvement in survival of patients affected with this disease due to the development of anti-HER2 targeted therapies. The approval of trastuzumab and pertuzumab associated to a taxane in first line and subsequent treatment with the antibody-drug conjugate T-DM1 has certainly contributed to achieve these outcomes. The Tyrosine Kinase Inhibitor lapatinib was also approved in the basis of an improvement in progr...
Source: Breast - April 6, 2018 Category: Cancer & Oncology Authors: Escrivá-de-Romaní S, Arumí M, Bellet M, Saura C Tags: Breast Source Type: research

Breast reconstruction with Alloderm Ready to Use: A meta-analysis of nine observational cohorts.
CONCLUSION: Four HADM products, AlloDerm-RTU, FD AlloDerm, AlloMax, and DermACELL, showed similar risks of complications. However since most of the included studies had a low level of evidence, further random trials with large numbers of patients are needed. PMID: 29631098 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - April 6, 2018 Category: Cancer & Oncology Authors: Wu LH, Zhang MX, Chen CY, Fang QQ, Wang XF, Tan WQ Tags: Breast Source Type: research

Incidence of isolated local breast cancer recurrence and contralateral breast cancer: A systematic review.
Abstract An increasing number of women is surviving breast cancer and due to that at risk of developing an isolated ipsilateral breast tumor recurrence (IBTR) or a contralateral breast cancer (CBC). Patients' main concern is cancer recurrence. Patient counseling on breast cancer recurrence is challenging. In order to provide healthcare professionals and patients more guidance, a systematic literature review of the incidence of isolated IBTR and CBC in women diagnosed with early invasive breast cancer was performed. Medline, EMBASE and the Cochrane Library were searched from 2000 until October 2015. Multicenter stu...
Source: Breast - April 2, 2018 Category: Cancer & Oncology Authors: Spronk I, Schellevis FG, Burgers JS, de Bock GH, Korevaar JC Tags: Breast Source Type: research

Social relationships, inflammation markers, and breast cancer incidence in the Women's Health Initiative.
CONCLUSION: Larger social networks were associated with lower inflammation and greater social strain was associated with higher inflammation. Higher inflammation might be associated with development of in situ breast cancer, but this appeared to be due to factors other than social relationships. PMID: 29614476 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 31, 2018 Category: Cancer & Oncology Authors: Busch EL, Whitsel EA, Kroenke CH, Yang YC Tags: Breast Source Type: research

Personalized prevention in high risk individuals: Managing hormones and beyond.
Abstract Increasing numbers of women are being identified at 'high-risk' of breast cancer, defined by The National Institute of Health and Care Excellence (NICE) as a 10-year risk of ≥8%. Classically women have been so identified through family history based risk algorithms or genetic testing of high-risk genes. Recent research has shown that assessment of mammographic density and single nucleotide polymorphisms (SNPs), when combined with established risk factors, trebles the number of women reaching the high risk threshold. The options for risk reduction in such women include endocrine chemoprevention with the...
Source: Breast - March 30, 2018 Category: Cancer & Oncology Authors: Evans DG, Howell SJ, Howell A Tags: Breast Source Type: research

MicroRNA co-expression patterns unravel the relevance of extra cellular matrix and immunity in breast cancer.
CONCLUSIONS: We then identified novel miRNA patterns associated with BC molecular features, and described a complex regulatory network where miRNAs belonging to the same module cooperate in finely tuning gene expression. PMID: 29597130 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 26, 2018 Category: Cancer & Oncology Authors: Dugo M, Huang X, Iorio MV, Cataldo A, Tagliabue E, Daidone MG, Wu J, Orlandi R Tags: Breast Source Type: research

Health-related quality of life and utility scores of patients with breast neoplasms in China: A multicenter cross-sectional survey.
This study aimed to derive utility scores of patients with breast cancer and precancer in China. MATERIAL AND METHODS: An interviewer-administered cross-sectional survey was conducted in 12 provinces across China from 2013 to 2014. The three-level EuroQol-5-Dimension instrument was used to evaluate quality of life, and utility scores were generated using the Chinese value set. Univariate and multivariate analyses were performed to explore the determinants of utility scores. RESULTS: In total, 2626 breast cancer and 471 precancer patients were included. Mean age was 49.1 for breast cancer and 41.4 years for precancer (p 
Source: Breast - March 26, 2018 Category: Cancer & Oncology Authors: Wang L, Shi JF, Zhu J, Huang HY, Bai YN, Liu GX, Liao XZ, Mao AY, Ren JS, Sun XJ, Guo LW, Fang Y, Zhou Q, Ma HM, Xing XJ, Zhu L, Song BB, Du LB, Mai L, Liu YQ, Ren Y, Lan L, Zhou JY, Qi X, Sun XH, Lou PA, Wu SL, Li N, Zhang K, He J, Dai M, Health Economic Tags: Breast Source Type: research

The performance of one-step nucleic acid amplification assay for intraoperative detection of sentinel lymph node macrometastasis in breast cancer: An updated meta-analysis.
CONCLUSION: OSNA assay is an accurate molecular diagnosis for intraoperative detection of sentinel lymph node macrometastasis in breast cancer. PMID: 29574393 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 22, 2018 Category: Cancer & Oncology Authors: Shi F, Liang Z, Zhang Q, Wang C, Liu X Tags: Breast Source Type: research

Reply to the letter "Body mass index and clinical outcomes in trastuzumab-treated metastatic breast cancer patients: An alternative explanation for the lack of association".
Reply to the letter "Body mass index and clinical outcomes in trastuzumab-treated metastatic breast cancer patients: An alternative explanation for the lack of association". Breast. 2018 Mar 16;: Authors: Poletto E, Martel S, Lambertini M, Puglisi F PMID: 29555407 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 16, 2018 Category: Cancer & Oncology Authors: Poletto E, Martel S, Lambertini M, Puglisi F Tags: Breast Source Type: research

Validated tools measuring women's satisfaction in breast cancer screening programmes: A systematic review.
l;nen L Abstract International guidelines recommend assessing women's satisfaction with breast cancer screening programmes; however, validated tools are needed. A systematic review to identify and evaluate the quality of validated instruments for screening satisfaction, from 01/1965 until 11/2017 was performed. From 3283 individual citations, six instruments were identified. Evaluation of the MammoGraphy Questionnaire using the COSMIN checklist resulted in 'good' to 'excellent' scores in most assessed domains, while the other tools were mostly 'poor'/'fair' quality or did not provide enough information for assessm...
Source: Breast - March 10, 2018 Category: Cancer & Oncology Authors: Deandrea S, Salakari M, Neamţiu L, Ulutürk A, Lerda D, Pylkkänen L Tags: Breast Source Type: research

Body mass index and clinical outcomes in trastuzumab-treated metastatic breast cancer patients: An alternative explanation for the lack of association.
PMID: 29530641 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 9, 2018 Category: Cancer & Oncology Authors: Nabi H, Diorio C Tags: Breast Source Type: research

Are we ready for the challenge of implementing risk-based breast cancer screening and primary prevention?
CONCLUSION: The present review identified considerable unresolved issues and challenges. Potential implementation will require a more complex framework, in which a country's healthcare regulations, resources, and preferences related to screening and prevention services are taken into account. However, with the insights gained from the present overview, countries expecting to implement risk-based screening and prevention can start to inventory and address the issues that were identified. PMID: 29529454 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 9, 2018 Category: Cancer & Oncology Authors: Rainey L, van der Waal D, Jervaeus A, Wengström Y, Evans DG, Donnelly LS, Broeders MJM Tags: Breast Source Type: research

Ultrasound-based prediction of pathologic response to neoadjuvant chemotherapy in breast cancer patients.
CONCLUSION: US imaging is insufficient to predict pCR with adequate accuracy. Receptor subtypes, however, affect diagnostic precision of US and pathologic outcome. PMID: 29518677 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 5, 2018 Category: Cancer & Oncology Authors: Baumgartner A, Tausch C, Hosch S, Papassotiropoulos B, Varga Z, Rageth C, Baege A Tags: Breast Source Type: research

Reply to Woodward: A standard mastectomy should not be the only recommended breast surgical treatment for non-metastatic inflammatory breast cancer.
PMID: 29510949 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - March 3, 2018 Category: Cancer & Oncology Authors: Chen H, Wu K, Wang M, Wang F, Zhang M, Zhang P Tags: Breast Source Type: research

Endocrine therapy and palbociclib within a compassionate use program in heavily pretreated hormone receptor-positive, HER2-negative metastatic breast cancer.
art M Abstract This is a single center retrospective analysis of patients with hormone receptor-positive, HER2-negative metastatic breast cancer progressing after ≥ 4 treatment lines treated with palbociclib in combination with endocrine therapy within a compassionate use program. Thirty-four patients were included between 10/2015 and 02/2017, the majority (82.4%) being previously treated with mTOR inhibitors. Disease control rate was 52.9% and 24.4% at week 12 and 24. Overall progression-free survival was 3.1 months with no difference between mTOR inhibitor-pretreated (3.5 months) and -naïve patients...
Source: Breast - February 20, 2018 Category: Cancer & Oncology Authors: Maurer C, Ferreira AR, Martel S, Lambertini M, Pondé N, Aftimos P, de Azambuja E, Piccart M Tags: Breast Source Type: research

Is OSNA better than imprint cytology for intraoperative diagnosis of cancer involvement of axillary sentinel node in breast cancer?
CONCLUSIONS: IC has been stated as a good technique for intraoperative cancer involvement SN with high sensitivity and NPV compared to the OSNA assay. It allows keeping the whole node tissue and thus the possibility of improved histopathological evaluation, which can be useful for adjuvant, and offers the advantage of being less time consuming. Cost analysis shows a higher cost for OSNA, which may exceed the benefit of sorting out false negatives from IC. PMID: 29455041 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - February 15, 2018 Category: Cancer & Oncology Authors: Luna-Tomás MA, Solà-Suárez M, Mariscal-Martínez A, Castellà-Fernández E, Martínez-Román S, Pascual-Miguel I, Quiroga-García V, Julián-Ibáñez JF Tags: Breast Source Type: research

Nipple-sparing bilateral prophylactic mastectomy and immediate reconstruction with TiLoop ® Bra mesh in BRCA1/2 mutation carriers: A prospective study of long-term and patient reported outcomes using the BREAST-Q.
Nipple-sparing bilateral prophylactic mastectomy and immediate reconstruction with TiLoop® Bra mesh in BRCA1/2 mutation carriers: A prospective study of long-term and patient reported outcomes using the BREAST-Q. Breast. 2018 Feb 15;39:8-13 Authors: Casella D, Di Taranto G, Marcasciano M, Sordi S, Kothari A, Kovacs T, Lo Torto F, Cigna E, Ribuffo D, Calabrese C Abstract BACKGROUND: Although demand for prophylactic mastectomy is increasing over time among women at a high risk for breast cancer, there is a paucity of studies on long term patient-reported outcomes after this procedure. METHODS: ...
Source: Breast - February 15, 2018 Category: Cancer & Oncology Authors: Casella D, Di Taranto G, Marcasciano M, Sordi S, Kothari A, Kovacs T, Lo Torto F, Cigna E, Ribuffo D, Calabrese C Tags: Breast Source Type: research

Mastectomy patterns, but not rates, are changing in the treatment of early breast cancer. Experience of a single European institution on 2315 consecutive patients.
We report on 15-year trends of mastectomy, mastectomy plus immediate reconstruction and contralateral prophylactic mastectomy (CPM) at an academic institution. METHODS: We identified women diagnosed with unilateral early breast cancer at stage 0-IIa, with tumour size ≤ 4 cm, between 2002 and 2016. Trends were assessed using the Cochrane-Armitage test. Multivariable logistic regression was used to identify factors associated with receipt of mastectomy plus immediate reconstruction. RESULTS: A total of 2315 patients were identified. Of them, 65.7% underwent breast conserving surgery (BCS), while 34.3% unde...
Source: Breast - February 14, 2018 Category: Cancer & Oncology Authors: Fancellu A, Sanna V, Cottu P, Feo CF, Scanu AM, Farina G, Bulla A, Spanu A, Paliogiannis P, Porcu A Tags: Breast Source Type: research

Impact of timeliness of adjuvant chemotherapy and radiotherapy on the outcomes of breast cancer; a pooled analysis of three clinical trials.
CONCLUSION: Among hormone receptor-negative patients, delaying chemotherapy initiation beyond 6 weeks (after surgery) is associated with worse patient outcomes. Moreover, delaying radiotherapy initiation beyond surgery does not compromise outcomes in patients receiving long course adjuvant chemotherapy. PMID: 29432980 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - February 9, 2018 Category: Cancer & Oncology Authors: Abdel-Rahman O Tags: Breast Source Type: research

A quantitative analysis of tumour characteristics in breast cancer patients with extranodal extension in non-sentinel nodes.
This study determined incidence of ENE at NSLN metastasis in patients with a positive SLN biopsy without ENE in 162 symptomatic breast cancer patients who underwent AC between 2009 and 2014 at Cork University Hospital Breast Cancer Service, a teaching hospital of University College Cork. RESULTS: Of 965 sentinel node biopsies performed 251 were identified as SLN positive, 162 (64.5%) underwent further AC. Of the 162 patients, 56.8% (92/162) were positive for ENE at SLN, of these 57.6% (53/92) had NSLN metastasis versus 17.1% (12/70) in the ENE-negative group (χ2 test; P 
Source: Breast - February 3, 2018 Category: Cancer & Oncology Authors: O'Keeffe NA, O'Neill C, Zahere A, Livingstone V, Browne TJ, Redmond HP, Corrigan MA Tags: Breast Source Type: research

Comparison of failure patterns between tubular breast carcinoma and invasive ductal carcinoma (KROG 14-25).
CONCLUSIONS: The TC of breast presents an excellent prognosis, but the contralateral breast cancer tends to be more frequently observed compared to IDC in Korean women. PMID: 29413404 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - January 30, 2018 Category: Cancer & Oncology Authors: Cho WK, Choi DH, Lee J, Park W, Kim YB, Suh CO, Shin KH, Jeon SH, Kim K, Park KR, Kim JH, Ahn SJ, Yoon WS, Yang DS, Kim J, Lee JH, Yea JW Tags: Breast Source Type: research

Reconstructive surgery and persistent postsurgical pain after mastectomy.
PMID: 29395982 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - January 30, 2018 Category: Cancer & Oncology Authors: Kendall MC, Castro Alves LJ Tags: Breast Source Type: research

Reply to Kendall and Castro-Alves: Reconstructive surgery and persistent postsurgical pain after mastectomy.
PMID: 29395983 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - January 30, 2018 Category: Cancer & Oncology Authors: Roth RS, Qi J, Hamill JB, Wilkins EG, Kim HM, Ballard TNS, Pusic AL Tags: Breast Source Type: research

Interval breast cancers in the 'screening with tomosynthesis or standard mammography' (STORM) population-based trial.
CONCLUSION: Interval breast cancer rate amongst screening participants in the STORM trial was marginally lower (and screening sensitivity higher) than estimates amongst 2D-screened women; these findings should be interpreted with caution given the small number of interval cases and the sample size of the trial. Much larger screening studies, or pooled analyses, are required to examine interval cancer rates arising after breast tomosynthesis screening versus digital mammography screening. PMID: 29328943 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - January 9, 2018 Category: Cancer & Oncology Authors: Houssami N, Bernardi D, Caumo F, Brunelli S, Fantò C, Valentini M, Romanucci G, Gentilini MA, Zorzi M, Macaskill P Tags: Breast Source Type: research

Addressing the paradox of increasing mastectomy rates in an era of de-escalation of therapy: Communication strategies.
Abstract Breast conservation therapy (BCT) was established as the preferred modality of surgical treatment for early stage breast cancer in the early 1990's. Yet, rising mastectomy rates have been observed over the last decade. This increase is a cause for concern as recent large population-based studies have consistently reported improved breast cancer-specific survival and local control rates with BCT, in comparison with mastectomy. There is a pressing need to formulate strategies to effectively inform both patients and practitioners about current data, in the hope of reversing rising mastectomy rates to optimis...
Source: Breast - January 8, 2018 Category: Cancer & Oncology Authors: Tan MP, Silva E Tags: Breast Source Type: research

First-line vs second-line fulvestrant for hormone receptor-positive advanced breast cancer: A post-hoc analysis of the CONFIRM study.
CONCLUSION: The superiority of fulvestrant 500 mg over fulvestrant 250 mg in patients with LA/MBC in CONFIRM was consistent in both the first- and second-line settings for PFS, and numerically greater in both settings for OS. PMID: 29324303 [PubMed - as supplied by publisher] (Source: Breast)
Source: Breast - January 8, 2018 Category: Cancer & Oncology Authors: Di Leo A, Jerusalem G, Torres R, Verhoeven D, Pendergrass K, Malorni L, Lichfield J, Martin M Tags: Breast Source Type: research