Factors influencing the time to diagnosis and treatment of breast cancer among women in low- and middle-income countries: A systematic review
CONCLUSIONS: Guidelines or consensus recommendations are essential for defining the optimal time intervals to BC diagnosis and treatment. Our review supported WHO's Global Breast Cancer Initiative recommendations. Increasing public awareness, strengthening of healthcare professional's capacities, partial decentralization of diagnostic services and implementation of effective referral mechanisms are recommended to achieve a shorter time to diagnosis and treatment of BC in LMICs.PMID:38522173 | DOI:10.1016/j.breast.2024.103714 (Source: Breast)
Source: Breast - March 24, 2024 Category: Cancer & Oncology Authors: Ranjeeta Subedi Nehmat Houssami Carolyn Nickson Anant Nepal Denise Campbell Michael David Xue Qin Yu Source Type: research

Factors influencing the time to diagnosis and treatment of breast cancer among women in low- and middle-income countries: A systematic review
CONCLUSIONS: Guidelines or consensus recommendations are essential for defining the optimal time intervals to BC diagnosis and treatment. Our review supported WHO's Global Breast Cancer Initiative recommendations. Increasing public awareness, strengthening of healthcare professional's capacities, partial decentralization of diagnostic services and implementation of effective referral mechanisms are recommended to achieve a shorter time to diagnosis and treatment of BC in LMICs.PMID:38522173 | DOI:10.1016/j.breast.2024.103714 (Source: Breast)
Source: Breast - March 24, 2024 Category: Cancer & Oncology Authors: Ranjeeta Subedi Nehmat Houssami Carolyn Nickson Anant Nepal Denise Campbell Michael David Xue Qin Yu Source Type: research

Is Oncotype DX testing informative for breast cancers with low ER expression? A retrospective review from a biomarker testing referral center
CONCLUSION: ODX does not appear to add significant additional information to inform treatment decisions for most patients with ER-low BC. Incorporating weak ER staining intensity in addition to low percentage of nuclear positivity identifies about twice as many ER-low patients, although with reduced specificity for high RS. Our study supports the contention that most ER-low early BC should be regarded similarly to ER-negative BC.PMID:38520994 | DOI:10.1016/j.breast.2024.103715 (Source: Breast)
Source: Breast - March 23, 2024 Category: Cancer & Oncology Authors: John Loggie Penelope J Barnes Michael D Carter Daniel Rayson Gillian C Bethune Source Type: research

Is Oncotype DX testing informative for breast cancers with low ER expression? A retrospective review from a biomarker testing referral center
CONCLUSION: ODX does not appear to add significant additional information to inform treatment decisions for most patients with ER-low BC. Incorporating weak ER staining intensity in addition to low percentage of nuclear positivity identifies about twice as many ER-low patients, although with reduced specificity for high RS. Our study supports the contention that most ER-low early BC should be regarded similarly to ER-negative BC.PMID:38520994 | DOI:10.1016/j.breast.2024.103715 (Source: Breast)
Source: Breast - March 23, 2024 Category: Cancer & Oncology Authors: John Loggie Penelope J Barnes Michael D Carter Daniel Rayson Gillian C Bethune Source Type: research

Gender minorities in breast cancer - Clinical trials enrollment disparities: Focus on male, transgender and gender diverse patients
CONCLUSIONS: We confirmed that gender minorities are severely underrepresented among BC registration trials. We observed a lower rate of men in trials envisaging endocrine manipulation or in less contemporary trials. This work sought to urge the scientific community to increase the awareness level towards the issue of gender minorities and to endorse more inclusive criteria in clinical trials.PMID:38493590 | PMC:PMC10959718 | DOI:10.1016/j.breast.2024.103713 (Source: Breast)
Source: Breast - March 17, 2024 Category: Cancer & Oncology Authors: Federica Miglietta Letizia Pontolillo Carmine De Angelis Roberta Caputo Monica Marino Emilio Bria Rossana Di Rienzo Annarita Verrazzo Carlo Buonerba Giampaolo Tortora Giuseppe Di Lorenzo Lucia Del Mastro Mario Giuliano Filippo Montemurro Fabio Puglisi Val Source Type: research

Gender minorities in breast cancer - Clinical trials enrollment disparities: Focus on male, transgender and gender diverse patients
CONCLUSIONS: We confirmed that gender minorities are severely underrepresented among BC registration trials. We observed a lower rate of men in trials envisaging endocrine manipulation or in less contemporary trials. This work sought to urge the scientific community to increase the awareness level towards the issue of gender minorities and to endorse more inclusive criteria in clinical trials.PMID:38493590 | DOI:10.1016/j.breast.2024.103713 (Source: Breast)
Source: Breast - March 17, 2024 Category: Cancer & Oncology Authors: Federica Miglietta Letizia Pontolillo Carmine De Angelis Roberta Caputo Monica Marino Emilio Bria Rossana Di Rienzo Annarita Verrazzo Carlo Buonerba Giampaolo Tortora Giuseppe Di Lorenzo Lucia Del Mastro Mario Giuliano Filippo Montemurro Fabio Puglisi Val Source Type: research

Gender minorities in breast cancer - Clinical trials enrollment disparities: Focus on male, transgender and gender diverse patients
CONCLUSIONS: We confirmed that gender minorities are severely underrepresented among BC registration trials. We observed a lower rate of men in trials envisaging endocrine manipulation or in less contemporary trials. This work sought to urge the scientific community to increase the awareness level towards the issue of gender minorities and to endorse more inclusive criteria in clinical trials.PMID:38493590 | DOI:10.1016/j.breast.2024.103713 (Source: Breast)
Source: Breast - March 17, 2024 Category: Cancer & Oncology Authors: Federica Miglietta Letizia Pontolillo Carmine De Angelis Roberta Caputo Monica Marino Emilio Bria Rossana Di Rienzo Annarita Verrazzo Carlo Buonerba Giampaolo Tortora Giuseppe Di Lorenzo Lucia Del Mastro Mario Giuliano Filippo Montemurro Fabio Puglisi Val Source Type: research

Gender minorities in breast cancer - Clinical trials enrollment disparities: Focus on male, transgender and gender diverse patients
CONCLUSIONS: We confirmed that gender minorities are severely underrepresented among BC registration trials. We observed a lower rate of men in trials envisaging endocrine manipulation or in less contemporary trials. This work sought to urge the scientific community to increase the awareness level towards the issue of gender minorities and to endorse more inclusive criteria in clinical trials.PMID:38493590 | DOI:10.1016/j.breast.2024.103713 (Source: Breast)
Source: Breast - March 17, 2024 Category: Cancer & Oncology Authors: Federica Miglietta Letizia Pontolillo Carmine De Angelis Roberta Caputo Monica Marino Emilio Bria Rossana Di Rienzo Annarita Verrazzo Carlo Buonerba Giampaolo Tortora Giuseppe Di Lorenzo Lucia Del Mastro Mario Giuliano Filippo Montemurro Fabio Puglisi Val Source Type: research

Gender minorities in breast cancer - Clinical trials enrollment disparities: Focus on male, transgender and gender diverse patients
CONCLUSIONS: We confirmed that gender minorities are severely underrepresented among BC registration trials. We observed a lower rate of men in trials envisaging endocrine manipulation or in less contemporary trials. This work sought to urge the scientific community to increase the awareness level towards the issue of gender minorities and to endorse more inclusive criteria in clinical trials.PMID:38493590 | DOI:10.1016/j.breast.2024.103713 (Source: Breast)
Source: Breast - March 17, 2024 Category: Cancer & Oncology Authors: Federica Miglietta Letizia Pontolillo Carmine De Angelis Roberta Caputo Monica Marino Emilio Bria Rossana Di Rienzo Annarita Verrazzo Carlo Buonerba Giampaolo Tortora Giuseppe Di Lorenzo Lucia Del Mastro Mario Giuliano Filippo Montemurro Fabio Puglisi Val Source Type: research

Platinum chemotherapy for early triple-negative breast cancer
CONCLUSIONS: Platinum-based chemotherapy using carboplatin in the adjuvant or neoadjuvant setting improves long-term outcomes of DFS and OS in early TNBC, with no evidence of differences by subgroup. This was at the cost of more frequent chemotherapy delays and dose reductions, and greater haematological toxicity. These findings support the use of platinum-based chemotherapy for people with early TNBC.PMID:38492276 | DOI:10.1016/j.breast.2024.103712 (Source: Breast)
Source: Breast - March 16, 2024 Category: Cancer & Oncology Authors: Sofia Re Mason Melina L Willson Sam J Egger Jane Beith Rachel F Dear Annabel Goodwin Source Type: research

Platinum chemotherapy for early triple-negative breast cancer
CONCLUSIONS: Platinum-based chemotherapy using carboplatin in the adjuvant or neoadjuvant setting improves long-term outcomes of DFS and OS in early TNBC, with no evidence of differences by subgroup. This was at the cost of more frequent chemotherapy delays and dose reductions, and greater haematological toxicity. These findings support the use of platinum-based chemotherapy for people with early TNBC.PMID:38492276 | DOI:10.1016/j.breast.2024.103712 (Source: Breast)
Source: Breast - March 16, 2024 Category: Cancer & Oncology Authors: Sofia Re Mason Melina L Willson Sam J Egger Jane Beith Rachel F Dear Annabel Goodwin Source Type: research

Accuracy of sentinel lymph node biopsy in male breast cancer: Systematic review and meta-analysis
CONCLUSION: SLNB for male breast cancer, following negative preoperative axillary assessment and primary surgery, appears feasible, consistent, and effective. Our research supports conducting immediate SLNB histological evaluation to facilitate prompt ALND in case of positive results.PMID:38461570 | PMC:PMC10940173 | DOI:10.1016/j.breast.2024.103703 (Source: Breast)
Source: Breast - March 10, 2024 Category: Cancer & Oncology Authors: Guillaume Parpex Marie Ottaviani Henri Lorphelin Matthieu Mezzadri Eva Marchand Laurence Cahen-Doidy Jean Louis Benifla Cyrille Huchon Camille Mimoun Source Type: research

Accuracy of sentinel lymph node biopsy in male breast cancer: Systematic review and meta-analysis
CONCLUSION: SLNB for male breast cancer, following negative preoperative axillary assessment and primary surgery, appears feasible, consistent, and effective. Our research supports conducting immediate SLNB histological evaluation to facilitate prompt ALND in case of positive results.PMID:38461570 | DOI:10.1016/j.breast.2024.103703 (Source: Breast)
Source: Breast - March 10, 2024 Category: Cancer & Oncology Authors: Guillaume Parpex Marie Ottaviani Henri Lorphelin Matthieu Mezzadri Eva Marchand Laurence Cahen-Doidy Jean Louis Benifla Cyrille Huchon Camille Mimoun Source Type: research

Accuracy of sentinel lymph node biopsy in male breast cancer: Systematic review and meta-analysis
CONCLUSION: SLNB for male breast cancer, following negative preoperative axillary assessment and primary surgery, appears feasible, consistent, and effective. Our research supports conducting immediate SLNB histological evaluation to facilitate prompt ALND in case of positive results.PMID:38461570 | DOI:10.1016/j.breast.2024.103703 (Source: Breast)
Source: Breast - March 10, 2024 Category: Cancer & Oncology Authors: Guillaume Parpex Marie Ottaviani Henri Lorphelin Matthieu Mezzadri Eva Marchand Laurence Cahen-Doidy Jean Louis Benifla Cyrille Huchon Camille Mimoun Source Type: research

Accuracy of sentinel lymph node biopsy in male breast cancer: Systematic review and meta-analysis
CONCLUSION: SLNB for male breast cancer, following negative preoperative axillary assessment and primary surgery, appears feasible, consistent, and effective. Our research supports conducting immediate SLNB histological evaluation to facilitate prompt ALND in case of positive results.PMID:38461570 | DOI:10.1016/j.breast.2024.103703 (Source: Breast)
Source: Breast - March 10, 2024 Category: Cancer & Oncology Authors: Guillaume Parpex Marie Ottaviani Henri Lorphelin Matthieu Mezzadri Eva Marchand Laurence Cahen-Doidy Jean Louis Benifla Cyrille Huchon Camille Mimoun Source Type: research