Mogamulizumab-induced Mucocutaneous Lichenoid Reaction: A Case Report and Short Review.
bos G PMID: 32449779 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - May 25, 2020 Category: Dermatology Authors: Trager MH, de Clippelé D, Ram-Wolff C, de Masson A, Vignon-Pennamen MD, Battistella M, Michel L, Bagot M, Dobos G Tags: Acta Derm Venereol Source Type: research

Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma.
m M Abstract Although recent therapeutic developments raise hope, melanoma remains a devastating disease with a need for new treatment targets. In other tumours prohormone convertases have been shown to be pro-tumourigenic as they are involved in processing preforms of matrix-metalloproteinases, growth factors and adhesion molecules. The aim of this study was to look for new treatment options for melanoma, by investigating the role of the prohormone convertase Paired basic Amino acid-Cleaving Enzyme 4 (PACE4/PCSK6) in melanoma cell lines and human melanoma tissue. PACE4-transfected A375 melanoma cells displayed si...
Source: Acta Dermato-Venereologica - May 25, 2020 Category: Dermatology Authors: Weishaupt C, Mastofrancesco A, Metze D, Kemper B, Stegemann A, Picardo M, Klein-Szanto AJP, Böhm M Tags: Acta Derm Venereol Source Type: research

Face Mask-induced Itch: A Self-questionnaire Study of 2,315 Responders During the COVID-19 Pandemic.
Abstract Little is known about itch related to the use of face masks. This internet survey study investigated the prevalence, intensity and clinical characteristics of itch related to the use of face masks by the general public during the COVID-19 pandemic. A total of 2,315 replies were received, of which 2,307 were included in the final analysis. Of the respondents, 1,393 (60.4%) reported using face masks during the previous week, and, of these, 273 (19.6%) participants reported having itch. Subjects who reported sensitive skin and atopic predisposition, and those with facial dermatoses (acne, atopic dermatitis o...
Source: Acta Dermato-Venereologica - May 25, 2020 Category: Dermatology Authors: Szepietowski JC, Matusiak Ł, Szepietowska M, Krajewski P, Białynicki-Birula R Tags: Acta Derm Venereol Source Type: research

Psychological Consequences of the Most Common Dermatoses: Data from the Objectifs Peau Study.
MA Abstract The prevalence of psychological disorders in patients with common skin diseases was assessed in a large representative sample of the French adult population. General health, as measured by the EQ5D score, was significantly lower if patients reported having rosacea, atopic dermatitis, urticaria, fungal infections, psoriasis or acne. The proportions of participants reporting being extremely anxious or depressed were higher in those who reported having rosacea, atopic dermatitis or contact dermatitis. Difficulties in sexual or conjugal life were frequently reported by people with psoriasis, atopic dermat...
Source: Acta Dermato-Venereologica - May 25, 2020 Category: Dermatology Authors: Misery L, Taïeb C, Schollhammer M, Bertolus S, Coulibaly E, Feton-Danou N, Michel L, Seznec JC, Versapuech J, Joly P, Corgibet F, Ezzedine K, Richard MA Tags: Acta Derm Venereol Source Type: research

Indirect Comparison of Combined BRAF and MEK Inhibition in Melanoma Patients with Elevated Baseline Lactate Dehydrogenase.
Abstract The approval of BRAF and MEK inhibitors has significantly improved treatment outcomes for patients with BRAF-mutated metastatic melanoma. The 3 first-line targeted therapy trials have provided similar results, and thus the identification of predictive biomarkers may generate a more precise basis for clinical decision-making. Elevated baseline lactate dehydrogenase (LDH) has already been determined as a strong prognostic factor. Therefore, this indirect analysis compared subgroups with elevated baseline LDH across the pivotal targeted therapy trials co-BRIM, COMBI-v and COLUMBUS part 1. The Bucher method w...
Source: Acta Dermato-Venereologica - May 25, 2020 Category: Dermatology Authors: Glutsch V, Amaral T, Garbe C, Thoms KM, Mohr P, Hauschild A, Schilling B Tags: Acta Derm Venereol Source Type: research

Umbilicated Papules on the Face of an Adult Patient: A Quiz.
PMID: 32449785 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - May 25, 2020 Category: Dermatology Authors: Robert J, Legrand M, Vermes E, Monegier du Sorbier C, Machet L Tags: Acta Derm Venereol Source Type: research

Patient-oriented Eczema Measure score: a Useful Tool for Web-Based Surveys in Patients with Atopic Dermatitis.
Abstract The Patient-Oriented Eczema Measure (POEM, 0-28 points) is a self-assessed, repeatable measurement tool for measuring atopic dermatitis (AD) severity. How-ever, whether POEM score is influenced by allergic comorbidities and whether POEM's severity banding is applicable in web-based surveys for AD remain unclear. A web-based questionnaire survey was conducted in 329 patients with AD. POEM, self-reported severity of AD, and comorbidity of allergic diseases including asthma, pollen rhinitis, allergic conjunctivitis, and food allergy were assessed. POEM scores were not affected by a history of comorbid allerg...
Source: Acta Dermato-Venereologica - May 25, 2020 Category: Dermatology Authors: Kido-Nakahara M, Nakahara T, Yasukochi Y, Ulzii D, Furue M Tags: Acta Derm Venereol Source Type: research

Pain in Atopic Dermatitis: An Online Population-based Survey.
;eb C, Misery L Abstract Pruritus in atopic dermatitis has been studied extensively; however, evaluation of skin pain has been very limited. The aim of this study was to evaluate the presence, frequency and characteristics of skin pain in patients with atopic dermatitis. A survey was conducted of a representative sample of 5,000 18-80-year-old individuals selected from the French population according to sex, age, geographical area and socioprofessional status. Data on socio-demographic status and the presence of any skin disease were collected. Pain in the past month and health-related quality of life were evaluat...
Source: Acta Dermato-Venereologica - May 19, 2020 Category: Dermatology Authors: Huet F, Shourick J, Séité S, Taïeb C, Misery L Tags: Acta Derm Venereol Source Type: research

Non-bullous Lichen Planus Pemphigoides: A Case Report.
;th B PMID: 32424432 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - May 19, 2020 Category: Dermatology Authors: Lamberts A, Diercks GFH, Pas HH, Horváth B Tags: Acta Derm Venereol Source Type: research

Novel CLDN1 Deletion Associated with Ichthyosis, Sclerosing Cholangitis and Acquired Alopecia.
PMID: 32424433 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - May 19, 2020 Category: Dermatology Authors: Alsafri MS, Charbit-Henrion F, Lacaille F, Bourrat E, Steffann J, Hadj-Rabia S Tags: Acta Derm Venereol Source Type: research

Clinical and Ultrasonographic Profile of Adalimumab-treated Hidradenitis Suppurativa Patients: A Real-life Monocentric Experience.
Abstract Ultrasonography has proven useful for diagnosis and treatment monitoring in patients with hidradenitis suppurativa. The aim of this study was to assess the clinical response to adalimumab using ultrasound findings. This prospective study collected data on demographic features, disease severity, and hidradenitis suppurativa findings from patients with hidradenitis suppurativa treated with adalimumab. Generalized estimating equations investigated relationships between disease severity measures and clinical/demographic variables. The study included a total of 41 patients with hidradenitis suppurativa who wer...
Source: Acta Dermato-Venereologica - May 18, 2020 Category: Dermatology Authors: Chiricozzi A, Giovanardi G, Garcovich S, Malvaso D, Caldarola G, Fossati B, Guerriero C, de Simone C, Peris K Tags: Acta Derm Venereol Source Type: research

Prevalence of Prurigo Nodularis in Poland.
This study assessed the prevalence of prurigo nodularis in Poland using publicly maintained database case records and diagnostic codes for prurigo nodularis (L28.1) and other prurigo (L28.2). For the period 2016-18, the prevalence of prurigo nodularis increased from 5.82 to 6.52 cases per 100,000 population. The total prevalence of all prurigo diagnoses over the same period remained relatively stable, with a small increase from 9.04 to 9.26 cases per 100,000 population. Regional data largely followed the overall trend. In an analysis of 58 prurigo nodularis cases identified at the Department of Dermatology at the Universit...
Source: Acta Dermato-Venereologica - May 18, 2020 Category: Dermatology Authors: Ryczek A, Reich A Tags: Acta Derm Venereol Source Type: research

Implication of Perifollicular Clusters and Folliculotropic Distribution of Dendritic Cells in the Pathogenesis of Seborrhoeic Dermatitis.
In conclusion, folliculotropic distribution of dendritic cells as well as dendritic cell-immune cell clusters play an important role in the pathogenesis of seborrhoeic dermatitis. PMID: 32421200 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - May 18, 2020 Category: Dermatology Authors: Ito A, Sugita K, Goto H, Yamamoto O Tags: Acta Derm Venereol Source Type: research

Flow Cytometry-based Detection of B-cell Lymphoproliferative Disorders in Patients with Mycosis Fungoides.
PMID: 32421201 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - May 18, 2020 Category: Dermatology Authors: Geller S, Kay S, Ellenbogen E, Goldsmith T, Bar-On S, Warshauer E, Deutsch V, Sprecher E, Perry C, Goldberg I Tags: Acta Derm Venereol Source Type: research

Skin Microbiome in Atopic Dermatitis.
Abstract Atopic dermatitis is a common inflammatory skin disease with a complex pathogenesis that includes imbalanced immune system signalling, impaired skin barrier and enhanced Staphylococcus aureus skin colonization. The skin bacterial communities are characterized by increasing abundance of S. aureus, leading to reduced diversity compared with the bacterial communities on healthy skin, and increasing disease severity. In contrast, fungal communities are richer and more diverse on the skin of patients with atopic dermatitis, although distribution of the most common species is similar in patients and controls. F...
Source: Acta Dermato-Venereologica - May 15, 2020 Category: Dermatology Authors: Edslev SM, Agner T, Andersen PS Tags: Acta Derm Venereol Source Type: research

Prevention of Atopic Dermatitis.
Abstract Despite advances in atopic dermatitis (AD) treatments, research into AD prevention has been slow. Systematic reviews of prevention strategies promoting exclusive and prolonged breastfeeding, or interventions that reduce ingested or airborne allergens during pregnancy and after birth have generally not shown convincing benefit. Maternal/infant supplements such as Vitamin D have also not shown any benefit with the possible exception of omega-3 fatty acids. Systematic reviews suggest that probiotics could reduce AD incidence by around 20%, although the studies are quite variable and might benefit from indivi...
Source: Acta Dermato-Venereologica - May 15, 2020 Category: Dermatology Authors: Williams HC, Chalmers J Tags: Acta Derm Venereol Source Type: research

A Therapeutic Renaissance - Emerging Treatments for Atopic Dermatitis.
Abstract Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease that is characterized by complex immune dysregulation and skin barrier dysfunction with a wide variety of clinical phenotypes. Until recently, conventional therapeutic modalities for AD remained rather non-specific despite AD's complex etiology. Failing to take into account the underlying inflammatory pathways led to treatments with inadequate efficacy or unacceptable long-term toxicities. We are currently in the midst of a therapeutic renaissance in AD. Recent progress in molecular medicine provides us a better understanding of the AD pa...
Source: Acta Dermato-Venereologica - May 15, 2020 Category: Dermatology Authors: Na CH, Baghoomian W, Simpson EL Tags: Acta Derm Venereol Source Type: research

Disease Mechanisms in Atopic Dermatitis: A Review of Aetiological Factors.
This article reviews epidemiological, clinical and experimental data to provide an overview of the most important disease mechanisms in atopic dermatitis. Genetic predisposition, environmental insults, atopic triggers, complex host immune response and skin barrier changes, and altered skin microbiota are discussed. Whilst our understanding of atopic dermatitis has improved dramatically in recent years, many basic aspects are still not understood. Further research is needed to fully understand this complex skin disease. PMID: 32412642 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - May 15, 2020 Category: Dermatology Authors: Thyssen JP, Rinnov MR, Vestergaard C Tags: Acta Derm Venereol Source Type: research

Counting the Burden: Atopic Dermatitis and Health-related Quality of Life.
Abstract Atopic dermatitis is the most prevalent chronic inflammatory skin condition globally. The burden of atopic dermatitis on children and adults is extensive and there is also significant impact on the lives of patient caregivers and family members. It is important to be able to measure this impact to inform clinical decisions and to plan appropriate patient and carer support. The current impact of atopic dermatitis on children and adults can be measured using several different quality of life questionnaires: the most frequently used are the Dermatology Quality of Life (DLQI), Children's Dermatology Quality o...
Source: Acta Dermato-Venereologica - May 15, 2020 Category: Dermatology Authors: Ali F, Vyas J, Finlay AY Tags: Acta Derm Venereol Source Type: research

Prevalence and Incidence of Atopic Dermatitis: A Systematic Review.
ing; Abstract The primary objective of this study was to systematically review and analyse epidemiological studies of the prevalence and incidence of atopic dermatitis (AD) during childhood and adulthood, focusing on data from the 21st century. A systematic search of PubMed, EMBASE and Google (manual search) was performed in June 2019, followed by data abstraction and study quality assessment (Newcastle-Ottawa Scale). Cross-sectional and longitudinal epidemiological studies of individuals with AD (doctor-diagnosed or standardized definition) were included. Of 7,207 references reviewed, 378 moderate/good-quality st...
Source: Acta Dermato-Venereologica - May 15, 2020 Category: Dermatology Authors: Bylund S, Kobyletzki LB, Svalstedt M, Svensson Å Tags: Acta Derm Venereol Source Type: research

Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects.
Abstract Atopic dermatitis (AD) is a common, complex trait, arising from the interplay of multiple genetic and environmental factors. This review provides an overview of developments in the field of AD genetics. AD shows high heritability; strategies to investigate genetic risk include linkage, candidate gene studies, genome-wide association and animal modelling. Loss-of-function mutations in FLG, encoding the skin barrier protein filaggrin, remain the strongest genetic risk factor identified for AD, but variants influencing skin and systemic immune function are also important. AD is at the forefront of genetic re...
Source: Acta Dermato-Venereologica - May 15, 2020 Category: Dermatology Authors: Brown SJ, Elias MS, Bradley M Tags: Acta Derm Venereol Source Type: research

Erratum.
Authors: PMID: 32391567 [PubMed - in process] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - May 11, 2020 Category: Dermatology Tags: Acta Derm Venereol Source Type: research

Genital Psoriasis and Associated Factors of Sexual Avoidance - A People-centered Cross-sectional Study in Germany.
This study aimed to assess the occurrence of genital psoriasis and to determine factors associated with the avoidance of sexual activities due to psoriasis in a non-clinical setting. A cross-sectional, person-centered, and online-based nationwide survey was conducted in Germany between March and June 2019. A multiple logistic regression model was used to analyze the data. Furthermore, free-text answers were provided. Overall, 344 individuals with psoriasis participated. Of these, 198 (57.6%) reported having genital psoriasis and 261 (75.9%) currently received medical care. Duration of psoriasis, subjective overall severity...
Source: Acta Dermato-Venereologica - May 7, 2020 Category: Dermatology Authors: Schielein MC, Tizek L, Schuster B, Ziehfreund S, Biedermann T, Zink A Tags: Acta Derm Venereol Source Type: research

A Randomized, Double-blind, Placebo-controlled Clinical Study to Investigate the efficacy of Herring Roe Oil for treatment of Psoriasis.
N, Bjørndal B Abstract The effect of omega-3 polyunsaturated fatty acid supplements in patients with Psoriasis vulgaris has previously been investigated, but interventions varied in source, composition, dose, administration route and duration of treatment. The observed beneficial effects in patients with Psoriasis vulgaris using as a dietary supplement prompted this investigation. This randomised, double blind and placebo controlled study was designed and performed to explore the efficacy and safety of herring roe oil supplementation in 64 patients with plaque psoriasis (ClinicalTrials.gov: NCT03359577). T...
Source: Acta Dermato-Venereologica - May 7, 2020 Category: Dermatology Authors: Tveit KS, Brokstad KA, Berge RK, Sæbø PC, Hallaråker H, Brekke S, Meland N, Bjørndal B Tags: Acta Derm Venereol Source Type: research

Annular Sarcoidosis with Geographic Appearance in a Patient with Systemic Sarcoidosis.
PMID: 32378725 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - May 7, 2020 Category: Dermatology Authors: Takama H, Ohshima Y, Ando Y, Yanagishita T, Takahashi E, Tsuzuki T, Uchida K, Eishi Y, Akiyama M, Watanabe D Tags: Acta Derm Venereol Source Type: research

Oncostatin M Induction of Monocyte Chemoattractant Protein 1 is Inhibited by Anti-oncostatin M Receptor Beta Monoclonal Antibody KPL-716.
Abstract To evaluate cellular response to oncostatin M (OSM) in comparison to interleukin (IL)-31, we analyzed monocyte chemoattractant protein 1 (MCP-1) as a readout for OSM responses with and without IL-4, IL-13, anti-OSM receptor β monoclonal antibody KPL-716, and anti-IL-31 receptor α antibody in human epidermal keratinocytes and human dermal fibroblasts in vitro. In human epidermal keratinocytes, OSM significantly induced STAT3 or STAT1 phosphorylation and synergized with IL-13 or IL-4 in elevating MCP-1. In human dermal fibroblasts, OSM results were similar, and leukemia inhibitory factor or IL-31...
Source: Acta Dermato-Venereologica - May 6, 2020 Category: Dermatology Authors: Richards CD, Gandhi R, Botelho F, Ho L, Paolini JF Tags: Acta Derm Venereol Source Type: research

Cutaneous Manifestations of Granulomatosis with Polyangiitis: A Case Series Study.
ago S Abstract The aim of this study was to determine the prevalence and type of cutaneous manifestations which occur in patients with granulomatosis with polyangiitis and to explore the potential association between cutaneous and systemic involvement in these patients. A retrospective case series study was designed, including all granulomatosis with polyangiitis cases diagnosed between 2010 and 2018 at the Hospital Universitario Virgen de las Nieves. Thirty-nine patients with granulomatosis with polyangiitis were identified, of which 53.85% presented cutaneous manifestations. In decreasing order of frequency, the...
Source: Acta Dermato-Venereologica - May 6, 2020 Category: Dermatology Authors: Montero-Vilchez T, Martinez-Lopez A, Salvador-Rodriguez L, Del Carmen Ramírez-Barberena M, Tercedor-Sanchez J, Molina-Leyva A, Arias-Santiago S Tags: Acta Derm Venereol Source Type: research

Update of the Management of Cutaneous Squamous-cell Carcinoma.
Abstract For all primary cutaneous squamous cell carcinomas (cSCCs), physical examination should include full skin examination, recording of tumour diameter and regional lymph-node-basin status. Surgery is the treatment of choice, with a minimal 5-mm margin. For elderly patients with well-differentiated tumours, other surgical modalities can be explored. Surgery for organ-transplant recipients should not be delayed. The issue with cSCC is identifying high-risk tumours with staging, as this may alter treatment and follow-up schedules. Adjuvant radiation therapy should be considered for incomplete resection, when re...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Maubec E Tags: Acta Derm Venereol Source Type: research

Cutaneous Melanoma - A Review of Systemic Therapies.
Abstract Cutaneous malignant melanoma is a rare and aggressive cancer of the melanocytes of the skin. The majority of cutaneous melanomas are cured surgically, but a significant proportion are either metastatic at presentation or recur following resection. Historically, outcomes for patients with advanced melanoma were poor due to a paucity of effective treatment options. However, the past decade has seen the introduction of targeted therapies and immunotherapies which have revolutionised the treatment of advanced melanoma. This review will cover the systemic treatment of melanoma, with a description of available ...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Lee KA, Nathan P Tags: Acta Derm Venereol Source Type: research

Melanoma Genomics.
Abstract The incidence of cutaneous melanoma continues to increase in pale skinned peoples in Europe and elsewhere. Epidemiological studies identified genetically determined phenotypes such as pale skin, freckles and red hair, and sunburn as risk factors for this cancer. The development of many melanocytic naevi is also genetically determined and a strong melanoma risk phenotype. Not surprisingly then, genome wide association studies have identified pigmentation genes as common risk genes, and to a lesser extent, genes associated with melanocytic naevi. More unexpectedly, genes associated with telomere length have...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Newton-Bishop J, Bishop DT, Harland M Tags: Acta Derm Venereol Source Type: research

Melanoma Risk and Melanocyte Biology.
Abstract Cutaneous melanoma arises from melanocytes following genetic, epigenetic and allogenetic (i.e. other than epi/genetic) modifications. An estimated 10% of cutaneous melanoma cases are due to inherited variants or de novo mutations in approximately 20 genes, found using linkage, next-generation sequencing and association studies. Based on these studies, 3 classes of predisposing melanoma genes have been defined based on the frequency of the variants in the general population and lifetime risk of developing a melanoma: (i) ultra-rare variants with a high risk, (ii) rare with a moderate risk, and (iii) freque...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Bertrand JU, Steingrimsson E, Jouenne F, PBressac-de Aillerets B, Larue L Tags: Acta Derm Venereol Source Type: research

Biomarkers Predicting for Response and Relapse with Melanoma Systemic Therapy.
Abstract Introduction of new systemic therapies in the last 10 years has radically improved outcomes for melanoma patients. Even so, not all patients benefit. These two major drug classes, small molecule BRAF targeted kinase inhibitors and immune checkpoint inhibitors, both come at significant cost, with sometimes serious side effects as well as high expense for health services. Almost half of melanomas harbour a BRAFV600 mutation and virtually all patients receiving BRAF targeted therapy will experience some amount of response. However, duration of response with these agents is uncertain, due to acquired resistan...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Welsh SJ, Corrie PG Tags: Acta Derm Venereol Source Type: research

It's Not All Sunshine: Non-sun-related Melanoma Risk-factors.
Abstract There is increasing evidence that the behaviour of naevi and melanoma is under significant genetic and/or epigenetic control. Melanoma tumours behaves similarly all over the world. Many genes have now been implicated in melanoma risk and naevi number. Embryogenesis has also been important in the discovery of links between several neurological diseases and melanoma susceptibility. Telomere biology, which regulates cell senescence, is increasingly relevant in melanoma. Melanoma is often found in the context of family cancer syndromes and the identification of these families is important as screening for can...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Bataille V Tags: Acta Derm Venereol Source Type: research

Update in the Management of Basal Cell Carcinoma.
Abstract Basal cell carcinomas are the most frequent skin cancers in the fair-skinned adult population over 50 years of age. Their incidence is increasing throughout the world. Ultraviolet (UV) exposure is the major carcinogenic factor. Some genodermatosis can predispose to formation of basal cell carcinomas at an earlier age. Basal cell carcinomas are heterogeneous, from superficial or nodular lesions of good prognosis to very extensive difficult-to-treat lesions that must be discussed in multidisciplinary committees. Recent guidelines have updated the management of basal cell carcinoma. The prognosis is linked t...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Basset-Seguin N, Herms F Tags: Acta Derm Venereol Source Type: research

Melanoma Epidemiology and Sun Exposure.
Abstract The worldwide incidence of melanoma has increased rapidly over the last 50 years. Melanoma is the most common cancer found in the young adult population, and its incidence is very high among geriatric populations. The incidence of melanoma varies by sex, and this factor is also associated with differences in the anatomical site melanoma. Adolescent and young adult women have a higher incidence than men. This may be, in part, due to the greater use of sunbeds, as well as intentional sun exposure among girls and, in general, risky behaviours in seeking to suntan, due to socially-determined aesthetic needs. ...
Source: Acta Dermato-Venereologica - April 28, 2020 Category: Dermatology Authors: Raimondi S, Suppa M, Gandini S Tags: Acta Derm Venereol Source Type: research

Sutton Naevi as Melanoma Simulators: Can Confocal Microscopy Help in the Diagnosis?
This study retrospectively characterized lesions that had been excised in order to avoid the possibility of melanoma, which were subsequently diagnosed histologically as Sutton naevi (n = 21, 37%); plus typical white halo Sutton naevi monitored for 1 year (n = 13, 23%); and proven thin melanomas with histological regression features (n = 23, 40%). On dermoscopy, atypical Sutton naevi and melanomas were indistinguishable. Reflectance confocal microscopy demonstrated significant differences at the dermo-epidermal junction: marked dermo-epidermal junction thickening and non-edged pap...
Source: Acta Dermato-Venereologica - April 21, 2020 Category: Dermatology Authors: Brugués A, Ribero S, Martins de Silva V, Aguilera P, Garcia AP, Alós L, Malvehy J, Puig S, Carrera C Tags: Acta Derm Venereol Source Type: research

Evaluating the Efficacy of Crisaborole Using the Atopic Dermatitis Severity Index and Percentage of Affected Body Surface Area.
Abstract Crisaborole ointment, 2%, is a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis pools results from 2 phase 3 studies (ClinicalTrials.gov, NCT02118766 [AD-301]; NCT02118792 [AD-302]) to evaluate crisaborole efficacy in patients ≥ 2 years with mild-to-moderate atopic dermatitis (per Investigator's Static Global Assessment) using the Atopic Dermatitis Severity Index (ADSI) and percentage of treatable body surface area (%BSA). Patients were randomly assigned 2:1 to receive crisaborole (n = 1,016) or vehicle (n&th...
Source: Acta Dermato-Venereologica - April 21, 2020 Category: Dermatology Authors: Silverberg JI, Tallman AM, Ports WC, Gerber RA, Tan H, Zielinski MA Tags: Acta Derm Venereol Source Type: research

Actinic Keratosis Diagnosis and Increased Risk of Developing Skin Cancer: A 10-year Cohort Study of 17,651 Patients in Sweden.
In conclusion, a diagnosis of actinic keratosis, even in the absence of documentation of other features of chronic sun exposure, is a marker of increased risk of skin cancer, which should be addressed with individually directed preventive advice. PMID: 32314794 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 21, 2020 Category: Dermatology Authors: Guorgis G, Anderson CD, Lyth J, Falk M Tags: Acta Derm Venereol Source Type: research

Allergic Rhinitis and Asthma Among Adolescents with Psoriasis: A Population-based Cross-sectional Study.
In conclusion, amongst adolescents, psoriasis was found to be associated with allergic rhinitis and asthma. PMID: 32314795 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 21, 2020 Category: Dermatology Authors: Galili E, Barzilai A, Twig G, Caspi T, Daniely D, Shreberk-Hassidim R, Astman N Tags: Acta Derm Venereol Source Type: research

Cutaneous Clinico-Pathological Findings in three COVID-19-Positive Patients Observed in the Metropolitan Area of Milan, Italy.
PMID: 32315073 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 21, 2020 Category: Dermatology Authors: Gianotti R, Veraldi S, Recalcati S, Cusini M, Ghislanzoni M, Boggio F, Fox LP Tags: Acta Derm Venereol Source Type: research

Psychiatric Comorbidities in Non-psychogenic Chronic Itch, a US-based Study.
Abstract Research suggests that itch and psychiatric diseases are intimately related. In efforts to examine the prevalence of psychiatric diagnoses in patients with chronic itch not due to psychogenic causes, we conducted a retrospective chart review of 502 adult patients diagnosed with chronic itch in an outpatient dermatology clinic specializing in itch and assessed these patients for a co-existing psychiatric disease. Psychiatric disease was identified and recorded based on ICD-10 codes made at any point in time which were recorded in the patient's electronic medical chart, which includes all medical department...
Source: Acta Dermato-Venereologica - April 21, 2020 Category: Dermatology Authors: Golpanian RS, Lipman Z, Fourzali K, Fowler E, Yosipovitch G Tags: Acta Derm Venereol Source Type: research

Unexpected Hair Regrowth in a Patient with Longstanding Alopecia Universalis During Treatment of Recalcitrant Dermatomyositis with the Janus Kinase Inhibitor Ruxolitinib.
PMID: 32285135 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 8, 2020 Category: Dermatology Authors: Fetter T, Cuevas Rios G, Niebel D, Bieber T, Wenzel J Tags: Acta Derm Venereol Source Type: research

Prevalence of Indoor Tanning Among Teenagers in Norway Before and After Enforcement of Ban for Ages Under 18 Years.
;d MB PMID: 32285136 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 8, 2020 Category: Dermatology Authors: Robsahm TE, Stenehjem JS, Berge LA, Veierød MB Tags: Acta Derm Venereol Source Type: research

Psoriatic Dermal-derived Mesenchymal Stem Cells Reduce Keratinocyte Junctions, and Increase Glycolysis.
Abstract Although it is known that psoriatic dermal-derived mesenchymal stem cells (DMSCs) dysregulate keratinocyte proliferation, the biological activity profile of keratinocytes influenced by psoriatic DMSCs remain unknown. In the present study, we assessed the impact of psoriatic DMSCs on keratinocyte proliferation, differentiation, and glucose metabolism in normal human epidermal keratinocytes co-cultured with or without psoriatic DMSCs. Co-culture of normal human epidermal keratinocytes with psoriatic DMSCs downregulated expression levels of proteins associated with cell junction assembly (alpha-actinin-1, ca...
Source: Acta Dermato-Venereologica - April 8, 2020 Category: Dermatology Authors: Li J, Xing J, Lu F, Chang W, Liang N, Li J, Wang Y, Li X, Zhao X, Hou R, Man M, Yin G, Li X, Zhang K Tags: Acta Derm Venereol Source Type: research

Recurrent and Metastatic Cutaneous Squamous Cell Carcinomas in a Cohort of 774 Patients in Finland.
In conclusion, our study demonstrated recurrences and metastases even in the case of thin cutaneous squamous cell carcinomas and in high-risk cases close monitoring should be organised during the first years after diagnosis. PMID: 32255495 [PubMed - as supplied by publisher] (Source: Acta Dermato-Venereologica)
Source: Acta Dermato-Venereologica - April 7, 2020 Category: Dermatology Authors: Korhonen N, Ylitalo L, Luukkaala T, Itkonen J, Häihälä H, Jernman J, Snellman E, Palve J Tags: Acta Derm Venereol Source Type: research

The Management of Scabies in the 21st Century: Past, Advances and Potentials.
Abstract Scabies is one of the most common skin diseases worldwide, affecting 150-200 million people yearly. Scabies affects young children in particular, and has the greatest impact in poor overcrowded living conditions. The burden of the disease is now well characterized, including group A Streptococcus and Staphylococcus aureus bacterial superinfections, with reports of nephritis, acute rheumatic fever, or fatal invasive sepsis secondary to scabies. Management of scabies remains largely suboptimal from diagnosis to treatment, and progress in the development of new therapeutic measures leading to cure is urgentl...
Source: Acta Dermato-Venereologica - March 24, 2020 Category: Dermatology Authors: Bernigaud C, Fischer K, Chosidow O Tags: Acta Derm Venereol Source Type: research

A Hundred Years of Diagnosing Superficial Fungal Infections: Where Do We Come From, Where Are We Now and Where Would We Like To Go?
DML Abstract Superficial fungal infections have been known for hundreds of years. During the 20th century new diagnostic methods were developed and the taxonomy changed several times, which, unfortunately, resulted in many fungi having several names (synonyms). The taxonomy is important, as species-specific identification guides clinicians when choosing the most appropriate antifungal agent, and provides an indication of the source of infection (anthropophilic, zoophilic or geophilic). Traditional diagnostic tests (direct microscopy, culture and histopathology) are still widely used, but molecular-based methods, s...
Source: Acta Dermato-Venereologica - March 24, 2020 Category: Dermatology Authors: Gräser Y, Saunte DML Tags: Acta Derm Venereol Source Type: research

The Changing Spectrum of Sexually Transmitted Infections in Europe.
Abstract As long as 400 years ago, syphilitic ulcers and gonococcal discharge were observed in connection with sexual intercourse. War, poverty, and lack of efficient therapeutic options led to a high incidence of venereal diseases, many of which had devastating outcomes. This situation continued until the beginning of the 20th century, when the microbial aetiology of venereal diseases was discovered. The infection rate dropped with the availability of antibiotic therapy after the Second World War. However, since the beginning of the 21st century, a steady increase in sexually transmitted infections (STIs) has bee...
Source: Acta Dermato-Venereologica - March 24, 2020 Category: Dermatology Authors: Stary A Tags: Acta Derm Venereol Source Type: research

Skin Disease in the Tropics and the Lessons that can be Learned from Leprosy and Other Neglected Diseases.
Abstract Skin disease is a common illness in most tropical regions where the pattern of clinical, presentations is dominated by infections. Along with common diseases such as pyodermas and fungal infections, a group of conditions known collectively as the neglected tropical diseases of the skin or Skin NTDs, which are the targets for worldwide control or elimination are also seen in health care facilities. These diseases range from the common, such a scabies, to those that are less frequent including leprosy and mycetoma. The initiative to use skin presentations of tropical diseases as a route to diagnosis by fron...
Source: Acta Dermato-Venereologica - March 24, 2020 Category: Dermatology Authors: Hay RJ Tags: Acta Derm Venereol Source Type: research

Skin Infections Caused by Staphylococcus aureus.
Abstract Staphylococcus aureus is the most common pathogen involved in skin infections worldwide, regardless of the patient's age, the climate or geographical area. The main skin clinical manifestations can be linked to a few toxins produced by the bacteria, which give rise to a rich and varied clinical spectrum. Panton Valentine leucocidin, exfoliatins, enterotoxins and toxin shock syndrome toxin 1 are the main toxins involved in most dermatological manifestations associated with S. aureus. Other less frequent cutaneous manifestations can occur in endocarditis, bacteraemia or related to a contiguity focus. Curren...
Source: Acta Dermato-Venereologica - March 24, 2020 Category: Dermatology Authors: Del Giudice P Tags: Acta Derm Venereol Source Type: research