Vancomycin pharmacokinetics in patients treated with intermittent haemodialysis based on therapeutic drug monitoring
J Chemother. 2021 Sep 23:1-8. doi: 10.1080/1120009X.2021.1979747. Online ahead of print.ABSTRACTVancomycin is frequently used in haemodialysis (HD) patients but generally accepted target serum ranges and dosing strategy are still lacking in this group. Based on retrospective analysis of data from 118 HD patients treated with vancomycin the interdialytic elimination constant (Ke), apparent volume of distribution (Vd) and dialysis efficacy were calculated. The influence of possible clinical variables on the pharmacokinetic parameters of vancomycin have been tested. The median of Ke in interdialytic periods, corresponding hal...
Source: Journal of Chemotherapy - September 23, 2021 Category: Cancer & Oncology Authors: Jan Miroslav Hartinger Martin Šíma Karol ína Hronová Barbora Ag átha Halouzková Barbora Szonowsk á Vladim ír Polakovič Vladim íra Bednářová Zuzana Hladinov á Vladim ír Tesař Ond řej Slanař Source Type: research

Brentuximab vedotin and bendamustine: an effective salvage therapy for relapsed or refractory Hodgkin lymphoma patients
J Chemother. 2021 Sep 13:1-9. doi: 10.1080/1120009X.2021.1976912. Online ahead of print.ABSTRACTThe prognosis is poor for relapsed or refractory (R/R) classical Hodgkin Lymphoma (cHL) patients. The brentuximab vedotin (Bv) and bendamustine (B) combination has been used as a preferable salvage regimen in R/R cHL patient trials. We retrospectively evaluated response rates, toxicities, and the survival in R/R cHL patients treated with the BvB combination. In a multi-centre real-life study, 61 R/R HL patients received intravenous doses of 1.8 mg/kg Bv on the first day plus 90 mg/m2 B on the first and second days of a 21-day cy...
Source: Journal of Chemotherapy - September 13, 2021 Category: Cancer & Oncology Authors: Bahar Uncu Ulu Mehmet Sinan Dal İpek Yönal Hindilerden Olga Meltem Akay Özgür Mehtap Nurhilal B üyükkurt Fehmi Hindilerden Ahmet K ürşad Güneş Tu ğçe Nur Yiğenoğlu Semih Ba şcı Merih K ızıl Çakar Didar Yanarda ğ Açık Serdal Korkmaz T Source Type: research

In-vitro activity of fosfomycin against < em > Escherichia < /em > < em > coli < /em > and < em > Klebsiella < /em > < em > pneumoniae < /em > bloodstream isolates and frequency of OXA-48, NDM, KPC, VIM, IMP types of carbapenemases in the carbapenem-resistant groups
J Chemother. 2021 Sep 8:1-6. doi: 10.1080/1120009X.2021.1963618. Online ahead of print.ABSTRACTThe aim of this study was to determine the in-vitro activity of fosfomycin against Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) isolates and the frequency of OXA-48, NDM, KPC, VIM, IMP types of carbapenemases in the carbapenem-resistant (CR) groups. A total of 346 isolates (126 E. coli and 220 K. pneumoniae) from nosocomial bloodstream infections were included. Carbapenem and fosfomycin susceptibility were tested by Etest (bioMerieux, France) and agar dilution methods, respectively and evaluated in accorda...
Source: Journal of Chemotherapy - September 8, 2021 Category: Cancer & Oncology Authors: P ınar Zarakolu Özgen Köseoğlu Eser Bar ış Otlu Öznur Gürpınar C üneyt Özakın Halis Akal ın İftihar Köksal Serhat Ünal Source Type: research

From clinical trials to clinical practice: the use of everolimus and exemestane in the treatment of hormone receptor-positive metastatic breast cancer: real-world data
J Chemother. 2021 Sep 6:1-6. doi: 10.1080/1120009X.2021.1959787. Online ahead of print.ABSTRACTEverolimus combined with exemestane can modulate endocrine resistance. The combination showed significant improvement in progression-free survival (PFS) in phase III clinical trials for hormone receptor positive metastatic breast cancer patients. It also showed serious adverse events. We evaluate the efficacy and prevalence of serious adverse events in a real-world setting. We retrospectively examined 91 breast cancer patients; all were previously treated with chemotherapy and fulvestrant (84% and 59%, respectively). After a 13-m...
Source: Journal of Chemotherapy - September 6, 2021 Category: Cancer & Oncology Authors: Hikmat Abdel-Razeq Baha' Sharaf Hazem Abdulelah Nayef Abdel-Razeq Mourad Salam Bayan Inserat Rayan Bater Source Type: research

Is ceftriaxone a suitable option for the empirical treatment of postoperative pleural empyema?
J Chemother. 2021 Aug 26:1. doi: 10.1080/1120009X.2021.1963619. Online ahead of print.NO ABSTRACTPMID:34435539 | DOI:10.1080/1120009X.2021.1963619 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - August 26, 2021 Category: Cancer & Oncology Authors: Hasan Tahsin Gozdas Source Type: research

Comparative incidence of acute kidney injury in patients on vancomycin therapy in combination with cefepime, piperacillin-tazobactam or meropenem
This study found a statistically significant difference in the incidence of AKI in patient receiving VPT when compared to VC or VM. This finding supports the need for careful monitoring of renal function in patients receiving VPT therapy and routine evaluation for de-escalation of antimicrobial therapy.PMID:34424136 | DOI:10.1080/1120009X.2021.1965334 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - August 23, 2021 Category: Cancer & Oncology Authors: Dhakrit Rungkitwattanakul Amy L Ives Nicole G Harriott Sarah Pan-Chen Lan Duong Source Type: research

Effect of HDAC9 inhibition on epithelial-mesenchymal transition in CD133+ prostate cancer cell lines
J Chemother. 2021 Aug 23:1-10. doi: 10.1080/1120009X.2021.1963615. Online ahead of print.ABSTRACTA small fraction of cancer cells known as cancer stem cells (CSCs) are considered to give rise to differentiated cancer cells and have been proposed to predict cancer recurrence and metastasis. There is further evidence that CSCs may act as metastatic precursors of epithelial-mesenchymal transition (EMT). In the present study, we investigated the key molecules involved in maintaining the stability of CSCs by inducing ectopic overexpression of CD133 to characterize EMT in human prostate cancer cell lines, including PC-3, DU145, ...
Source: Journal of Chemotherapy - August 23, 2021 Category: Cancer & Oncology Authors: Bora Kim Hong Moon Sohn Hoon Hyun Wonbong Lim Source Type: research

Inhibiting effect of < em > p < /em > -Coumaric acid on U87MG human glioblastoma cell growth
In conclusion, our results demonstrated that pCA acts influencing the cell viability and cell cycle of U87Mg cells by promoting cell cycle arrest in G2/M phase and apoptosis.PMID:34424147 | DOI:10.1080/1120009X.2021.1953888 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - August 23, 2021 Category: Cancer & Oncology Authors: Maria Antonietta Oliva Salvatore Castaldo Rossella Rotondo Sabrina Staffieri Massimo Sanchez Antonietta Arcella Source Type: research

Comparative incidence of acute kidney injury in patients on vancomycin therapy in combination with cefepime, piperacillin-tazobactam or meropenem
This study found a statistically significant difference in the incidence of AKI in patient receiving VPT when compared to VC or VM. This finding supports the need for careful monitoring of renal function in patients receiving VPT therapy and routine evaluation for de-escalation of antimicrobial therapy.PMID:34424136 | DOI:10.1080/1120009X.2021.1965334 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - August 23, 2021 Category: Cancer & Oncology Authors: Dhakrit Rungkitwattanakul Amy L Ives Nicole G Harriott Sarah Pan-Chen Lan Duong Source Type: research

Effect of HDAC9 inhibition on epithelial-mesenchymal transition in CD133+ prostate cancer cell lines
J Chemother. 2021 Aug 23:1-10. doi: 10.1080/1120009X.2021.1963615. Online ahead of print.ABSTRACTA small fraction of cancer cells known as cancer stem cells (CSCs) are considered to give rise to differentiated cancer cells and have been proposed to predict cancer recurrence and metastasis. There is further evidence that CSCs may act as metastatic precursors of epithelial-mesenchymal transition (EMT). In the present study, we investigated the key molecules involved in maintaining the stability of CSCs by inducing ectopic overexpression of CD133 to characterize EMT in human prostate cancer cell lines, including PC-3, DU145, ...
Source: Journal of Chemotherapy - August 23, 2021 Category: Cancer & Oncology Authors: Bora Kim Hong Moon Sohn Hoon Hyun Wonbong Lim Source Type: research

Inhibiting effect of < em > p < /em > -Coumaric acid on U87MG human glioblastoma cell growth
In conclusion, our results demonstrated that pCA acts influencing the cell viability and cell cycle of U87Mg cells by promoting cell cycle arrest in G2/M phase and apoptosis.PMID:34424147 | DOI:10.1080/1120009X.2021.1953888 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - August 23, 2021 Category: Cancer & Oncology Authors: Maria Antonietta Oliva Salvatore Castaldo Rossella Rotondo Sabrina Staffieri Massimo Sanchez Antonietta Arcella Source Type: research

Comparative incidence of acute kidney injury in patients on vancomycin therapy in combination with cefepime, piperacillin-tazobactam or meropenem
This study found a statistically significant difference in the incidence of AKI in patient receiving VPT when compared to VC or VM. This finding supports the need for careful monitoring of renal function in patients receiving VPT therapy and routine evaluation for de-escalation of antimicrobial therapy.PMID:34424136 | DOI:10.1080/1120009X.2021.1965334 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - August 23, 2021 Category: Cancer & Oncology Authors: Dhakrit Rungkitwattanakul Amy L Ives Nicole G Harriott Sarah Pan-Chen Lan Duong Source Type: research

Effect of HDAC9 inhibition on epithelial-mesenchymal transition in CD133+ prostate cancer cell lines
J Chemother. 2021 Aug 23:1-10. doi: 10.1080/1120009X.2021.1963615. Online ahead of print.ABSTRACTA small fraction of cancer cells known as cancer stem cells (CSCs) are considered to give rise to differentiated cancer cells and have been proposed to predict cancer recurrence and metastasis. There is further evidence that CSCs may act as metastatic precursors of epithelial-mesenchymal transition (EMT). In the present study, we investigated the key molecules involved in maintaining the stability of CSCs by inducing ectopic overexpression of CD133 to characterize EMT in human prostate cancer cell lines, including PC-3, DU145, ...
Source: Journal of Chemotherapy - August 23, 2021 Category: Cancer & Oncology Authors: Bora Kim Hong Moon Sohn Hoon Hyun Wonbong Lim Source Type: research

Inhibiting effect of < em > p < /em > -Coumaric acid on U87MG human glioblastoma cell growth
In conclusion, our results demonstrated that pCA acts influencing the cell viability and cell cycle of U87Mg cells by promoting cell cycle arrest in G2/M phase and apoptosis.PMID:34424147 | DOI:10.1080/1120009X.2021.1953888 (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - August 23, 2021 Category: Cancer & Oncology Authors: Maria Antonietta Oliva Salvatore Castaldo Rossella Rotondo Sabrina Staffieri Massimo Sanchez Antonietta Arcella Source Type: research

Calcium-oxidative stress signaling axis and casein kinase 1 α mediate eryptosis and hemolysis elicited by novel p53 agonist inauhzin
In this study, we investigate the mechanisms of INZ toxicity in human RBCs. RBCs were isolated from healthy donors and treated with antitumor concentrations of INZ (5-500 μM) for 24 h at 37 °C. Hemoglobin was photometrically measured, and cells were stained with Annexin-V-FITC for phosphatidylserine (PS), Fluo4/AM for calcium, and 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA) for oxidative stress. INZ caused significant dose-responsive, calcium-dependent hemolysis starting at 40 μM. Furthermore, INZ significantly increased Annexin-positive cells and Fluo4 and DCF fluorescence. The cytotoxicity of INZ was a...
Source: Journal of Chemotherapy - August 19, 2021 Category: Cancer & Oncology Authors: Mohammad A Alfhili Essa Alsalmi Abdullah Aljedai Jawaher Alsughayyir Manal Abudawood Ahmed M Basudan Source Type: research

Fosfomycin therapeutic drug monitoring in real-life: development and validation of a LC-MS/MS method on plasma samples
J Chemother. 2021 Aug 19:1-10. doi: 10.1080/1120009X.2021.1963617. Online ahead of print.ABSTRACTIndividualization of fosfomycin dosing based on therapeutic drug monitoring (TDM) of plasma concentrations could reduce drug-related adverse events and improve clinical outcome in complex clinical conditions. Quantification of fosfomycin in plasma samples was performed by a rapid ultraperformance liquid chromatography mass spectrometry method. Sample preparation involved protein precipitation with [13C3]-fosfomycin benzylamine salt as internal standard. The calibration curve ranged from 2 to 800 mg/L. Within- and between-day pr...
Source: Journal of Chemotherapy - August 19, 2021 Category: Cancer & Oncology Authors: Sara Baldelli Matteo Cerea Davide Mangioni Laura Alagna Antonio Muscatello Alessandra Bandera Dario Cattaneo Source Type: research

Calcium-oxidative stress signaling axis and casein kinase 1 α mediate eryptosis and hemolysis elicited by novel p53 agonist inauhzin
In this study, we investigate the mechanisms of INZ toxicity in human RBCs. RBCs were isolated from healthy donors and treated with antitumor concentrations of INZ (5-500 μM) for 24 h at 37 °C. Hemoglobin was photometrically measured, and cells were stained with Annexin-V-FITC for phosphatidylserine (PS), Fluo4/AM for calcium, and 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA) for oxidative stress. INZ caused significant dose-responsive, calcium-dependent hemolysis starting at 40 μM. Furthermore, INZ significantly increased Annexin-positive cells and Fluo4 and DCF fluorescence. The cytotoxicity of INZ was a...
Source: Journal of Chemotherapy - August 19, 2021 Category: Cancer & Oncology Authors: Mohammad A Alfhili Essa Alsalmi Abdullah Aljedai Jawaher Alsughayyir Manal Abudawood Ahmed M Basudan Source Type: research

Fosfomycin therapeutic drug monitoring in real-life: development and validation of a LC-MS/MS method on plasma samples
J Chemother. 2021 Aug 19:1-10. doi: 10.1080/1120009X.2021.1963617. Online ahead of print.ABSTRACTIndividualization of fosfomycin dosing based on therapeutic drug monitoring (TDM) of plasma concentrations could reduce drug-related adverse events and improve clinical outcome in complex clinical conditions. Quantification of fosfomycin in plasma samples was performed by a rapid ultraperformance liquid chromatography mass spectrometry method. Sample preparation involved protein precipitation with [13C3]-fosfomycin benzylamine salt as internal standard. The calibration curve ranged from 2 to 800 mg/L. Within- and between-day pr...
Source: Journal of Chemotherapy - August 19, 2021 Category: Cancer & Oncology Authors: Sara Baldelli Matteo Cerea Davide Mangioni Laura Alagna Antonio Muscatello Alessandra Bandera Dario Cattaneo Source Type: research

Calcium-oxidative stress signaling axis and casein kinase 1 α mediate eryptosis and hemolysis elicited by novel p53 agonist inauhzin
In this study, we investigate the mechanisms of INZ toxicity in human RBCs. RBCs were isolated from healthy donors and treated with antitumor concentrations of INZ (5-500 μM) for 24 h at 37 °C. Hemoglobin was photometrically measured, and cells were stained with Annexin-V-FITC for phosphatidylserine (PS), Fluo4/AM for calcium, and 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA) for oxidative stress. INZ caused significant dose-responsive, calcium-dependent hemolysis starting at 40 μM. Furthermore, INZ significantly increased Annexin-positive cells and Fluo4 and DCF fluorescence. The cytotoxicity of INZ was a...
Source: Journal of Chemotherapy - August 19, 2021 Category: Cancer & Oncology Authors: Mohammad A Alfhili Essa Alsalmi Abdullah Aljedai Jawaher Alsughayyir Manal Abudawood Ahmed M Basudan Source Type: research

Fosfomycin therapeutic drug monitoring in real-life: development and validation of a LC-MS/MS method on plasma samples
J Chemother. 2021 Aug 19:1-10. doi: 10.1080/1120009X.2021.1963617. Online ahead of print.ABSTRACTIndividualization of fosfomycin dosing based on therapeutic drug monitoring (TDM) of plasma concentrations could reduce drug-related adverse events and improve clinical outcome in complex clinical conditions. Quantification of fosfomycin in plasma samples was performed by a rapid ultraperformance liquid chromatography mass spectrometry method. Sample preparation involved protein precipitation with [13C3]-fosfomycin benzylamine salt as internal standard. The calibration curve ranged from 2 to 800 mg/L. Within- and between-day pr...
Source: Journal of Chemotherapy - August 19, 2021 Category: Cancer & Oncology Authors: Sara Baldelli Matteo Cerea Davide Mangioni Laura Alagna Antonio Muscatello Alessandra Bandera Dario Cattaneo Source Type: research

Calcium-oxidative stress signaling axis and casein kinase 1 α mediate eryptosis and hemolysis elicited by novel p53 agonist inauhzin
In this study, we investigate the mechanisms of INZ toxicity in human RBCs. RBCs were isolated from healthy donors and treated with antitumor concentrations of INZ (5-500 μM) for 24 h at 37 °C. Hemoglobin was photometrically measured, and cells were stained with Annexin-V-FITC for phosphatidylserine (PS), Fluo4/AM for calcium, and 2',7'-dichlorodihydrofluorescein diacetate (H2DCFDA) for oxidative stress. INZ caused significant dose-responsive, calcium-dependent hemolysis starting at 40 μM. Furthermore, INZ significantly increased Annexin-positive cells and Fluo4 and DCF fluorescence. The cytotoxicity of INZ was a...
Source: Journal of Chemotherapy - August 19, 2021 Category: Cancer & Oncology Authors: Mohammad A Alfhili Essa Alsalmi Abdullah Aljedai Jawaher Alsughayyir Manal Abudawood Ahmed M Basudan Source Type: research

Fosfomycin therapeutic drug monitoring in real-life: development and validation of a LC-MS/MS method on plasma samples
J Chemother. 2021 Aug 19:1-10. doi: 10.1080/1120009X.2021.1963617. Online ahead of print.ABSTRACTIndividualization of fosfomycin dosing based on therapeutic drug monitoring (TDM) of plasma concentrations could reduce drug-related adverse events and improve clinical outcome in complex clinical conditions. Quantification of fosfomycin in plasma samples was performed by a rapid ultraperformance liquid chromatography mass spectrometry method. Sample preparation involved protein precipitation with [13C3]-fosfomycin benzylamine salt as internal standard. The calibration curve ranged from 2 to 800 mg/L. Within- and between-day pr...
Source: Journal of Chemotherapy - August 19, 2021 Category: Cancer & Oncology Authors: Sara Baldelli Matteo Cerea Davide Mangioni Laura Alagna Antonio Muscatello Alessandra Bandera Dario Cattaneo Source Type: research

Pediatric impetigo: an expert panel opinion about its main controversies
This article offers practical suggestions, given the existing evidence and experts' opinions, for correctly managing pediatric impetigo in both hospital and ambulatory settings. Italian physicians with an expertise on pediatric impetigo appointed a working group. A preliminary literature search using Pubmed/MEDLINE and Cochrane Library databases has been performed. The most common controversial issues about pediatric impetigo have been identified and then discussed from multidisciplinary perspectives, according to the 'structured controversy' methodology, a technique discovered and designed to get engaged in a controversy ...
Source: Journal of Chemotherapy - August 18, 2021 Category: Cancer & Oncology Authors: Luisa Galli Andrea Novelli Giuseppe Ruggiero Stefania Stefani Anna Belloni Fortina Source Type: research

< em > In vitro < /em > susceptibility of carbapenem-resistant Enterobacterales to eravacycline - the first report from Croatia
J Chemother. 2021 Aug 17:1-4. doi: 10.1080/1120009X.2021.1965335. Online ahead of print.ABSTRACTThe main obstacle in treatment of infections caused by carbapenem-resistant Enterobacterales (CRE) are limited treatment options. The novel antimicrobial agents other than β-lactams with activity not being dependent on β-lactamase class are especially important. Eravacycline (ERV) is the first fully synthetic fluorocycline indicated for the treatment of complicated intra-abdominal infections in adults. Eighty CRE isolates at the University Hospital Centre Zagreb, Croatia were examined for susceptibility to ERV by disc ...
Source: Journal of Chemotherapy - August 17, 2021 Category: Cancer & Oncology Authors: Ivana Juri ć Zrinka Bo šnjak Mario Ćorić Jo ško Lešin Ivana Marekovi ć Source Type: research

Infective endocarditis by < em > Enterobacter cloacae < /em > : a systematic review and meta-analysis
J Chemother. 2021 Aug 9:1-8. doi: 10.1080/1120009X.2021.1959786. Online ahead of print.ABSTRACTEnterobacter species are Gram-negative, non-spore-forming, facultative anaerobes typically motile due to the presence of peritrichous flagella. E. cloacae, the species responsible for the majority of Enterobacter infections in humans, is part of the intestinal microbiota and may cause infection in patients that have previously received antimicrobial therapy or who have been admitted to the Intensive Care Unit. E. cloacae may cause several infections, such as pneumonia, urinary tract, skin and soft tissue and intravascular infecti...
Source: Journal of Chemotherapy - August 9, 2021 Category: Cancer & Oncology Authors: Petros Ioannou Rodanthi Vamvoukaki Diamantis P Kofteridis Source Type: research

Clinical insights and prognostic factors from an advanced biliary tract cancer case series: a real-world analysis
J Chemother. 2021 Jul 27:1-10. doi: 10.1080/1120009X.2021.1953887. Online ahead of print.ABSTRACTAdvanced biliary tract cancer (aBTC) comprises a heterogeneous group of rare malignancies with dismal prognosis. Given the scarcity of prospective evidence, the aim of this study was to derive clinically useful insights and prognostic factors from a large, real-world series of aBTC. Clinicopathologic variables and treatment outcomes were retrospectively collected involving 940 patients diagnosed with aBTC between 2001 and 2017, and treated with first-line chemotherapy (CT1) at 14 Italian medical oncology institutions. Median ov...
Source: Journal of Chemotherapy - July 27, 2021 Category: Cancer & Oncology Authors: Roberto Filippi Francesco Leone Lorenzo Fornaro Giuseppe Aprile Andrea Casadei-Gardini Nicola Silvestris Andrea Palloni Maria Antonietta Satolli Mario Scartozzi Marco Russano Stefania Eufemia Lutrino Pasquale Lombardi Giorgio Frega Silvio Ken Garattini Ca Source Type: research