Evaluation of efficacy and safety of fosfomycin versus nitrofurantoin for the treatment of uncomplicated lower urinary tract infection (UTI) in women - A systematic review and meta-analysis
J Chemother. 2021 Jun 21:1-10. doi: 10.1080/1120009X.2021.1938949. Online ahead of print.ABSTRACTUrinary tract infections (UTI) are among the most frequent medical conditions requiring outpatient treatment. Single dose oral fosfomycin (300 mg) and the older nitrofurantoin (100 mg for 5 days) have been found to be more effective than other first-line drugs in multiple studies. This systematic review and meta-analysis were carried out with the objective of evaluating their comparative efficacy and safety in the management of uncomplicated UTI. Two authors independently searched PubMed, Cochrane Central, Embase, and Google Sc...
Source: Journal of Chemotherapy - June 21, 2021 Category: Cancer & Oncology Authors: Mahanjit Konwar Nithya J Gogtay Renju Ravi Urmila M Thatte Debdipta Bose Source Type: research

Comparison of lorlatinib, alectinib and brigatinib in ALK inhibitor-naive/untreated ALK-positive advanced non-small-cell lung cancer: a systematic review and network meta-analysis
J Chemother. 2021 Jun 17:1-10. doi: 10.1080/1120009X.2021.1937782. Online ahead of print.ABSTRACTBecause of lacking of head-to-head comparison among lorlatinib, alectinib and brigatinib for patients with ALK inhibitor-naive or untreated (ALK inhibitor-naive and chemotherapy-naive) ALK-positive advanced non-small-cell lung cancer (NSCLC), the optimal option for these patients still remains undefined. We searched published reports that described the activity and safety of those novel ALK inhibitors (lorlatinib, alectinib and brigatinib) for ALK inhibitor-naive or untreated (ALK inhibitor-naive and chemotherapy-naive) ALK-pos...
Source: Journal of Chemotherapy - June 18, 2021 Category: Cancer & Oncology Authors: Lida Wang Zhixin Sheng Junying Zhang Jiwu Song Lili Teng Liping Liu Qianpeng Li Baohong Wang Bin Li Source Type: research

Optimization of dosing regimens of vancomycin, teicoplanin, linezolid and daptomycin against methicillin-resistant < em > Staphylococcus aureus < /em > in neutropenic patients with cancer by Monte Carlo simulations
The objective of this study was to evaluate the efficacy of various dosing regimens of vancomycin, teicoplanin, linezolid and daptomycin against methicillin-resistant Staphylococcus aureus (MRSA) in neutropenic patients with cancer. Monte Carlo simulations were conducted using pharmacokinetic parameters and pharmacodynamic data to determine cumulative fraction of response (CFRs) in terms of area under the concentration-time curve/minimum inhibition concentration target. Currently clinical standard dosing regimens of vancomycin, teicoplanin, linezolid and daptomycin were insufficient to provide expected CFRs against MRSA fo...
Source: Journal of Chemotherapy - June 3, 2021 Category: Cancer & Oncology Authors: Xiaochen Wei Mingfeng Zhao Xia Xiao Source Type: research

Relationship between renal dysfunction and electrolyte abnormalities in hematopoietic stem cell transplant patients treated with foscarnet
This study aimed to investigate the relationship between renal dysfunction and electrolyte abnormalities, which are adverse events of foscarnet used for cytomegalovirus infection. Of the Ninety hematopoietic stem cell transplantation patients, 32 who met the selection criteria were enrolled in this retrospective study. The study patients were divided into two groups according to whether they developed renal dysfunction. The incidences of hypocalcemia, hypokalemia, and hypomagnesemia with an increase of grade 2 or higher in the renal dysfunction group were 45.5%, 18.2%, and 27.3%, respectively. Additionally, in the renal dy...
Source: Journal of Chemotherapy - June 1, 2021 Category: Cancer & Oncology Authors: Ryosuke Ota Atsushi Hirata Source Type: research

Novel daidzein molecules exhibited anti-prostate cancer activity through nuclear receptor ER β modulation, < em > in vitro < /em > and < em > in vivo < /em > studies
J Chemother. 2021 Jun 1:1-13. doi: 10.1080/1120009X.2021.1924935. Online ahead of print.ABSTRACTEight novel ERβ selective daidzein analogues (NCE1-8) were synthesized and their anti-cancer activity was evaluated by in vitro and in vivo methods. Cytotoxicity study, Receptor binding studies, Luciferase assay, cMYC & Cyclin D1 expression and Caspase 3, 8 & 9 activities were measured to ascertain the anticancer activity and mechanism. Uterotropic, anti-androgenic and anti-tumour activities were performed in rodents. The results revealed that NCEs produced anti-prostate cancer activity in DU145, LNCaP and PC3 cell ...
Source: Journal of Chemotherapy - June 1, 2021 Category: Cancer & Oncology Authors: R Ranjithkumar K Saravanan B Balaji S Hima S Sreeja S R Timane M Ram Pravin Kumar S Kabilan M Ramanathan Source Type: research

Pegylated liposomal doxorubicin as first line treatment in aids-related Kaposi's sarcoma: a real-life study
J Chemother. 2021 Jun 1:1-6. doi: 10.1080/1120009X.2021.1920248. Online ahead of print.ABSTRACTDespite the introduction of effective combination antiretroviral therapy (cART) AIDS-related Kaposi Sarcoma (AIDS-KS) remains the most common malignancy in HIV positive patients. In advanced stage or progressive forms, chemotherapy (CT) in combination with cART is the treatment of choice. The aim of the study is to evaluate efficacy and tolerability of Pegylated Liposomal Doxorubicin (PLD) as first line CT in AIDS-KS. In this single institution retrospective study PLD (20 mg/m2 IV every 2 weeks for 6 or 12 cycles) in combination ...
Source: Journal of Chemotherapy - June 1, 2021 Category: Cancer & Oncology Authors: Davide Dalu Cinzia Fasola Luca Ammoni Davide De Francesco Maria Silvia Cona Selene Rota Sabrina Ferrario Anna Gambaro Nicoletta Tosca Sheila Piva Nicla La Verde Source Type: research

Relationship between renal dysfunction and electrolyte abnormalities in hematopoietic stem cell transplant patients treated with foscarnet
This study aimed to investigate the relationship between renal dysfunction and electrolyte abnormalities, which are adverse events of foscarnet used for cytomegalovirus infection. Of the Ninety hematopoietic stem cell transplantation patients, 32 who met the selection criteria were enrolled in this retrospective study. The study patients were divided into two groups according to whether they developed renal dysfunction. The incidences of hypocalcemia, hypokalemia, and hypomagnesemia with an increase of grade 2 or higher in the renal dysfunction group were 45.5%, 18.2%, and 27.3%, respectively. Additionally, in the renal dy...
Source: Journal of Chemotherapy - June 1, 2021 Category: Cancer & Oncology Authors: Ryosuke Ota Atsushi Hirata Source Type: research

Novel daidzein molecules exhibited anti-prostate cancer activity through nuclear receptor ER β modulation, < em > in vitro < /em > and < em > in vivo < /em > studies
J Chemother. 2021 Jun 1:1-13. doi: 10.1080/1120009X.2021.1924935. Online ahead of print.ABSTRACTEight novel ERβ selective daidzein analogues (NCE1-8) were synthesized and their anti-cancer activity was evaluated by in vitro and in vivo methods. Cytotoxicity study, Receptor binding studies, Luciferase assay, cMYC & Cyclin D1 expression and Caspase 3, 8 & 9 activities were measured to ascertain the anticancer activity and mechanism. Uterotropic, anti-androgenic and anti-tumour activities were performed in rodents. The results revealed that NCEs produced anti-prostate cancer activity in DU145, LNCaP and PC3 cell ...
Source: Journal of Chemotherapy - June 1, 2021 Category: Cancer & Oncology Authors: R Ranjithkumar K Saravanan B Balaji S Hima S Sreeja S R Timane M Ram Pravin Kumar S Kabilan M Ramanathan Source Type: research

Pegylated liposomal doxorubicin as first line treatment in aids-related Kaposi's sarcoma: a real-life study
J Chemother. 2021 Jun 1:1-6. doi: 10.1080/1120009X.2021.1920248. Online ahead of print.ABSTRACTDespite the introduction of effective combination antiretroviral therapy (cART) AIDS-related Kaposi Sarcoma (AIDS-KS) remains the most common malignancy in HIV positive patients. In advanced stage or progressive forms, chemotherapy (CT) in combination with cART is the treatment of choice. The aim of the study is to evaluate efficacy and tolerability of Pegylated Liposomal Doxorubicin (PLD) as first line CT in AIDS-KS. In this single institution retrospective study PLD (20 mg/m2 IV every 2 weeks for 6 or 12 cycles) in combination ...
Source: Journal of Chemotherapy - June 1, 2021 Category: Cancer & Oncology Authors: Davide Dalu Cinzia Fasola Luca Ammoni Davide De Francesco Maria Silvia Cona Selene Rota Sabrina Ferrario Anna Gambaro Nicoletta Tosca Sheila Piva Nicla La Verde Source Type: research

Factors affecting the mortality rate of patients with cancer hospitalized with COVID-19: a single center's experience
J Chemother. 2021 May 25:1-10. doi: 10.1080/1120009X.2021.1923153. Online ahead of print.ABSTRACTThe main objective is to define the mortality of patients with cancer admitted to our hospital, their clinical and demographic characteristics, investigate the risk of COVID-19 for patients with cancer, and determine factors that affect the mortality rates of patients with cancer dying of COVID-19. A total of 2401 patients were admitted to our hospital with the diagnosis of COVID-19 from March 11th, 2020, to May 31st, 2020. Ninety-two out of a total of 112 cancer patients were included in this study based on the planned inclusi...
Source: Journal of Chemotherapy - May 25, 2021 Category: Cancer & Oncology Authors: Murat Ayhan Hatice Odabas Nedim Turan Deniz Tataroglu Ozyukseler Osman Kostek Gulin Alkan Evrim Abamor Mahmut Emre Yildirim Source Type: research

Rs3802278 in 3'-UTR of < em > SULF1 < /em > associated with platinum resistance and survival in Chinese epithelial ovarian cancer patients
This study aims to examine the role of polymorphisms in sulfatase 1 (SULF1) in platinum resistance and survival in advanced epithelial ovarian cancer (EOC) patients. We genotyped 12 SNPs of SULF1 in 195 EOC patients treated with platinum using MassARRAY method and evaluated the association between the SNPs and platinum response. SULF1 rs3802278 was marginal significantly associated with platinum resistance in recessive model with p value of 0.055. The patients with SULF1 rs3802278 AA were more resistant to platinum-based chemotherapy comparing to those with AG/GG genotype (OR: 2.317, 95%CI: 0.982 ∼ 5.465). In survival ...
Source: Journal of Chemotherapy - May 24, 2021 Category: Cancer & Oncology Authors: Feiyue Zeng Yujie Liu Qianying Ouyang Zeen Sun Keqiang Zhang Xi Li Yingzi Liu Source Type: research

Performance of capecitabine in novel combination therapies in colorectal cancer
J Chemother. 2021 May 21:1-15. doi: 10.1080/1120009X.2021.1920247. Online ahead of print.ABSTRACTColorectal cancer is one of the most common cancers throughout the world, and no definitive cure has ever been found. Perhaps a new insight into the effectiveness of chemotherapy drugs could help better treat patients. Targeted therapies have significantly improved the median overall survival of colorectal cancer patients. One of the standard chemotherapy regimens used for colorectal cancer is capecitabine, which is important in monotherapy and combination therapies. Capecitabine, with other chemotherapeutic agents (irinotecan,...
Source: Journal of Chemotherapy - May 21, 2021 Category: Cancer & Oncology Authors: Fahima Danesh Pouya Yousef Rasmi Irem Yalim Camci Yusuf Tutar Mohadeseh Nemati Source Type: research

Intraventricular treatment of paediatric meningitis due to extensively drug-resistant Gram-negative bacteria: two case reports and review of the literature
In this report, we describe two paediatric cases with central nervous system infections caused by extensively drug-resistant Gram-negative bacteria that were successfully treated with intraventricular colistin. To the best of our knowledge, this is the first comprehensive review and discussion of intraventricular antimicrobial therapy in a paediatric population. Based on our comprehensive review of the relevant literature, it appears that intraventricular administration of colistin may be a promising and effective option in the treatment of central nervous system infections in children who do not respond to other treatment...
Source: Journal of Chemotherapy - May 20, 2021 Category: Cancer & Oncology Authors: Melis Deniz An ıl Tapısız Alp Özgün Börcek Hasan Tezer Source Type: research

Anti-biofilm activity of dalbavancin against methicillin-resistant < em > Staphylococcus aureus < /em > (MRSA) isolated from human bone infection
J Chemother. 2021 Apr 27:1-6. doi: 10.1080/1120009X.2021.1911518. Online ahead of print.ABSTRACTThe presence of methicillin-resistant Staphylococcus aureus (MRSA) in bone infections difficults its treatment and is a sign of concern. The aim of this study was to evaluate in vitro activity of dalbavancin on pre-established adhered cells and 24 h old biofilms of MRSA strains isolated from a human bone infection. Thirty-three MRSA were isolated from osteomyelitis episodes. The antimicrobial susceptibility of these strains was assessed by the Kirby-Bauer disc diffusion method and the presence of resistance genes was screened by...
Source: Journal of Chemotherapy - April 27, 2021 Category: Cancer & Oncology Authors: Vanessa Silva Carla Miranda M ário Bezerra H Sofia Ant ão Jo ão Guimarães Justina Prada Isabel Pires Lu ís Maltez Jos é E Pereira Jos é L Capelo Gilberto Igrejas Patr ícia Poeta Source Type: research