The point prevalence and inappropriateness of antibiotic use at hospitals in Turkey: a systematic review and meta-analysis
J Chemother. 2021 Feb 23:1-10. doi: 10.1080/1120009X.2021.1888031. Online ahead of print.ABSTRACTInappropriate antimicrobial use is a key problem causing antimicrobial resistance and increased health care costs. Although global point prevalence surveys on antimicrobial prescribing in hospitals were described, there is lack of data from Turkish hospitals. Here, we aimed to perform systematic review and meta-analysis for the point prevalence surveys on antimicrobial prescribing in Turkish hospitals. The Preferred Reporting Items for Systematic reviews and Meta-Analyses guideline was used to identify studies for the review. A...
Source: Journal of Chemotherapy - February 23, 2021 Category: Cancer & Oncology Authors: Aysu Selcuk Source Type: research

Infective endocarditis by Klebsiella species: a systematic review.
This study aimed to systematically analyze all cases of infective endocarditis (IE) by Klebsiella species in the literature. A systematic review of PubMed, Scopus and Cochrane library (through 27th January 2021) for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of IE by Klebsiella species was performed. In this review, a total of 66 studies were included, providing data for 67 patients. A prosthetic valve was present in 16.4%, while the most common causative pathogen was K. pneumoniae followed by K. oxytoca. The aortic valve was the most commonly infected intracardiac s...
Source: Journal of Chemotherapy - February 21, 2021 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Risk of fatigue with PARP inhibitors in cancer patients: a systematic review and meta-analysis of 29 phase II/III randomized controlled trials.
Authors: Li J, Zhang Z Abstract Fatigue was a frequently reported adverse event associated with the use of PARP inhibitors. We performed a systematic review and meta-analysis to fully investigate the fatigue of PARP inhibitors in cancer patients. Databases were searched for randomized controlled trials (RCTs) treated with PARP inhibitors till July 2020. Twenty-nine RCTs and 9479 patients were included. This meta-analysis suggests that the use of PARP inhibitors significantly increase the risk of developing all-grade (RR, 1.25; 95%CI, 1.20-1.31; p 
Source: Journal of Chemotherapy - February 17, 2021 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Disseminated fusariosis in immunocompromised children: a case series and review of literature.
In this report, we present a series of three cases of children with acute lymphoblastic leukemia and disseminated fusariosis categorized according to the European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG). Furthermore, we present a current literature review focused on treatment using monotherapy or combined antifungal treatment. PMID: 33563140 [PubMed - as supplied by publisher] (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - February 12, 2021 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Recovery of borderline oxacillin-resistant Staphylococcus pseudintermedius (BORSP) from bone and soft tissue of a rheumatoid arthritis patient with severe osteoporosis: transmission from the family dog.
We report a case of borderline oxacillin-resistant S. pseudintermedius (BORSP) in a rheumatoid arthritis patient with severe osteoporosis. The organism is also resistant to erythromycin and clindamycin. We also present clear evidence on transmission from the family dog. PMID: 33517870 [PubMed - as supplied by publisher] (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - February 2, 2021 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Infective endocarditis in patients with liver cirrhosis: a systematic review.
Authors: Ioannou P, Savva E, Kofteridis DP Abstract Liver cirrhosis is an increasing cause of mortality and morbidity in developed countries. Infective Endocarditis (IE) is an uncommon disease with notable morbidity and mortality. Even though cirrhosis is associated with immune dysfunction and increased occurrence of bacterial infection, IE is infrequently diagnosed in these patients. Thus, the purpose of this study was to systematically review all published cases of IE in patients with cirrhosis in the literature. A systematic review of PubMed, Scopus and Cochrane (through 23th April 2020) for studies providing ep...
Source: Journal of Chemotherapy - January 30, 2021 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Effect of anthracyclines/ifosfamide-based adjuvant chemotherapy for soft tissue sarcoma: a conventional and network Meta-analysis.
The objective of this study is to assess the effect of anthracyclines/ifosfamide-based adjuvant chemotherapy for soft tissue sarcoma (STS) and provide a relative ranking of regimens for STS. We pooled the hazard ratios of overall survival (OS) and relapse free survival (RFS) by conventional meta-analysis to appraise whether adjuvant chemotherapy benefits STS and performed a network meta-analysis using a Bayesian model to establish the relative ranking of regimens. Nine studies were included in our meta-analysis. The pooled hazard ratios were 0.68 (95%CI: 0.53-0.86) and 0.65 (95%CI: 0.52-0.83) for OS and RFS, respectively. ...
Source: Journal of Chemotherapy - January 29, 2021 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Proinflammatory circulating markers: new players for evaluating asymptomatic acute cardiovascular toxicity in breast cancer treatment.
This study aimed to evaluate markers of cardiac damage (total CK, CKMB and CRP), inflammatory markers (free iron, homocysteine and TNF-α) as well as lipidogram in breast cancer patients undergoing acute cycles of doxorubicin (DOX), paclitaxel (PTX) or trastuzumab (TZ) and to verify if there is an association between these markers and the toxicity of the chemotherapeutic treatment. Methods: Included in the study were 120 breast cancer patients and 50 healthy controls. All analyzes were performed on automated systems. For the statistical analysis, each group was compared with the controls according to their normality b...
Source: Journal of Chemotherapy - January 23, 2021 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Natural substances to potentiate canonical glioblastoma chemotherapy.
Authors: Arcella A, Sanchez M Abstract Glioblastoma multiforme (GBM) is the most frequent primary malignant brain tumour prevalent in humans, that exhibits aggressive cell proliferation and rapid invasion of normal brain tissue. Despite aggressive therapeutic approaches consisting of maximum safe surgical resection followed by radio-chemotherapy with temozolomide (TMZ), more than 95% of GBM patients die within 5 years after diagnosis. In most cases, the therapy is not able to counteract the growth and invasiveness of the tumour, which relapses after an interval of time that varies from patient to patient. An...
Source: Journal of Chemotherapy - January 22, 2021 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Successful dalbavancin use in preventing reactivation of Staphylococcus aureus liver abscess during pre-engraftment neutropenia after allogeneic hematopoietic stem cell transplantation.
Authors: Dell'Orso G, Faraci M, Giardino S, Mariani M, Mesini A, Castagnola E PMID: 33459210 [PubMed - as supplied by publisher] (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - January 20, 2021 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Therapeutic options for COVID-19: a quick review.
Authors: Ismaila MS, Bande F, Ishaka A, Sani AA, Georges K Abstract Since the announcement by the World Health Organization (WHO) of an outbreak of a contagious respiratory viral pneumonia in Wuhan, China, in December 2019 (later named as COVID-19), several research works have been carried out to unstitch the therapeutic options and combat the disease using various aproaches and modalities. These works are currently at different clinical trial stages, and their results may be determined by the outcome of the ongoing trial process. There is the need for a collection of information regarding the availlable therapeuti...
Source: Journal of Chemotherapy - January 13, 2021 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Prognostic significance of sarcopenia and decreased relative dose intensity during the initial two cycles of first-line sunitinib for metastatic renal cell carcinoma.
Authors: Lee CH, Ku JY, Seo WI, Park YJ, Chung JI, Kim W, Park TY, Ha HK Abstract Targeted therapy for metastatic renal cell carcinoma (mRCC) treatment requires the identification of clinically important factors that can predict the therapeutic effect. We retrospectively investigated the prognostic roles of pre-treatment sarcopenia and relative dose intensity during the initial two cycles (2c-RDI) of sunitinib treatment in patients with mRCC. In total, 41 (52.6%) patients were classified as having sarcopenia and 16 (20.5%) patients were classified with low 2c-RDI at
Source: Journal of Chemotherapy - January 9, 2021 Category: Cancer & Oncology Tags: J Chemother Source Type: research

ESBL-producing Escherichia coli and Klebsiella pneumoniae from health-care institutions in Mexico.
Authors: Gallegos-Miranda V, Garza-Ramos U, Bolado-Martínez E, Navarro-Navarro M, Félix-Murray KR, Candia-Plata MDC, Sanchez-Martinez G, Dúran-Bedolla J, Silva-Sánchez J Abstract We investigated the phenotypic and molecular characteristics of Extended-Spectrum-β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae clinical isolates from four health-care institutions in Hermosillo, Sonora, Mexico. ESBL-producing isolates were collected from February to August 2016. The prevalence of ESBL-producing E. coli and K. pneumoniae was 11.9 and 8.7%, respectively. High dissem...
Source: Journal of Chemotherapy - December 30, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Prolonged clinical response with regorafenib administered as second-line therapy in an elderly patient suffering from peritoneal carcinomatosis of colon cancer.
Authors: Rosati G, Fé A Abstract Peritoneal carcinomatosis from colorectal cancer (CRC) has a poor prognosis with median survival and clinical responses that are worse than for other metastatic sites, and even more so in pretreated patients proposed for regorafenib therapy. Thus, patients with these characteristics are a therapeutic challange. The present study reports the case of an 83-year-old woman with diffuse peritoneal carcinomatosis from CRC, RAS-mutated, and treated with second-line therapy with the off-label administration of regorafenib at full dose (160 mg once daily, for the first 21&thins...
Source: Journal of Chemotherapy - December 30, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

The effectiveness of cetuximab and panitumumab when combined with FOLFIRI in second-line treatment of KRAS wild type metastatic colorectal cancers. Single centre experience.
In this study, we aimed to compare the efficacy of cetuximab vs panitumumab in patients who previously received chemotherapy. Who progressed after first-line treatment for K-ras wild type mCRC were analyzed. The efficacy of cetuximab vs panitumumab on overall survival (OS) and progression-free survival (PFS) when combined with FOLFIRI regimen was compared retrospectively. Median PFS was 6.9 months in the cetuximab group and 4.7 months in the panitumumab group. Median OS cetuximab and panitumumab groups were 18.4 and 12.2 months, respectively. In the second-line treatment of K-ras wild type mCRC, both P...
Source: Journal of Chemotherapy - December 24, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Endocarditis in kidney transplant recipients: a systematic review.
Authors: Ioannou P, Alexakis K, Kofteridis DP Abstract Infective Endocarditis (IE) carries significant mortality. Bacteremia, which is a predisposing factor for IE, occurs more frequently in immunocompromised individuals. Interestingly, IE in kidney transplant recipients has not been adequately described. The aim of this study was to systematically review all published cases of IE in kidney transplant recipients and describe their epidemiology, microbiology, clinical characteristics, treatment and outcomes. A systematic review of PubMed (through 13th December 2019) for studies providing epidemiological, clinical, m...
Source: Journal of Chemotherapy - December 19, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

The rising problem of hospital antimicrobial resistance and the challenges of antibiotic prescription in Brazil.
Authors: Urzedo JE, Menezes RP, Gontijo-Filho PP, Ribas RM PMID: 33272136 [PubMed - as supplied by publisher] (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - December 6, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Antibiotic susceptibility of Staphylococcus aureus isolated from skin lesions in children. A retrospective analysis from a tertiary care Italian pediatric hospital.
Authors: Lezzi M, Bandettini R, Ugolotti E, Saffioti C, Mesini A, Pastorino C, Manunza F, Ferretti M, Brisca G, Castagnola E Abstract Antibiotic susceptibility of S. aureus was retrospectively assessed in 1833 strains isolated from skin lesions observed in an Italian tertiary care hospital. Methicillin resistance was more frequent in outpatients than in inpatients (18% vs. 14%, p = 0.04) as well as resistance to cotrimoxazole (8% vs. 4.1%, p 
Source: Journal of Chemotherapy - December 6, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Prognostic factors and effect on survival of immune-related adverse events in patients with non-small-cell lung cancer treated with immune checkpoint blockage.
Authors: Conde-Estévez D, Monge-Escartín I, Ríos-Hoyo A, Monzonis X, Echeverría-Esnal D, Moliner L, Duran-Jordà X, Taus Á, Arriola E Abstract Our aim was to describe the incidence and characteristics of immune-related adverse events (irAEs) in patients with non-small-cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICI) and to evaluate their impact on outcome. All cases of NSCLC patients treated with ICIs in the second-line setting between December 2015 and May 2018 were evaluated. Seventy patients were included. Mean age was 65.9 years, and the ma...
Source: Journal of Chemotherapy - December 4, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

A plethora of carbapenem resistance in Acinetobacter baumannii: no end to a long insidious genetic journey.
Authors: Vahhabi A, Hasani A, Rezaee MA, Baradaran B, Hasani A, Samadi Kafil H, Abbaszadeh F, Dehghani L Abstract Acinetobacter baumannii, notorious for causing nosocomial infections especially in patients admitted to intensive care unit (ICU) and burn units, is best at displaying resistance to all existing antibiotic classes. Consequences of high potential for antibiotic resistance has resulted in extensive drug or even pan drug resistant A. baumannii. Carbapenems, mainly imipenem and meropenem, the last resort for the treatment of A. baumannii infections have fallen short due to the emergence of carbapenem resist...
Source: Journal of Chemotherapy - November 29, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Combination therapy of vancomycin and piperacillin/tazobactam in adult febrile neutropenia patients with haematopoietic malignancies increases the risk of acute kidney injury regardless of vancomycin trough concentration.
Authors: Sazanami K, Inose R, Dote S, Horiuchi N, Kobayashi Y, Muraki Y PMID: 33222657 [PubMed - as supplied by publisher] (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - November 24, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Transmembrane protein ADAM29 facilitates cell proliferation, invasion and migration in clear cell renal cell carcinoma.
Authors: Li SL, Jiang TQ, Cao QW, Liu SM Abstract Abnormal expression of ADAM29 has been frequently reported in several cancers, however, its role in clear cell renal cell carcinoma (ccRCC) has not evaluated in detail. Herein, we attempt to determine the biological role and the action mechanism of ADAM29 in ccRCC. Bioinformatics analysis based on the ccRCC RNA-Seq dataset from TCGA database revealed that ADAM29 was up-expressed in ccRCC tissues by comparison with normal tissues. And a significant increase of ADAM29 expression was also observed in 3 ccRCC cell lines (UT33A, Caki-1, and786-O) in comparison with norma...
Source: Journal of Chemotherapy - November 11, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Is pandrug-resistance in A. baumannii a transient phenotype? Epidemiological clues from a 4-year cohort study at a tertiary referral hospital in Greece.
In this study of 91 hospitalized patients with PDRAB we showed the frequent (60%) isolation of non-PDRAB, often susceptible only to colistin, aminoglycosides and/or tigecycline, preceding and/or following PDRAB isolation. However, the isolation of PDRAB in two outpatients, 25 and 36 days after their discharge from the hospital, suggests the potential of some PDRAB strains to persist even in the absence of antimicrobial pressure. PMID: 33124498 [PubMed - as supplied by publisher] (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - October 31, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Daptomycin-based aminoglycoside-sparing therapy for streptococcal endocarditis: a retrospective multicenter study.
Authors: Pallotto C, Sbrana F, Ripoli A, Lupia T, Corcione S, Paciosi F, Francisci D, Pasticci MB, Sozio E, Bertolino G, Carannante N, Rescigno C, Carozza A, Di Caprio G, Taddei E, Murri R, Fantoni M, Emdin M, Aimo A, De Rosa FG, Tascini C Abstract Streptococci still represent common etiologic agents of infective endocarditis (IE). Although renal failure is frequently reported as an aminoglycoside-associated adverse event, last international guidelines recommend a beta-lactam/gentamicin combination therapy. We retrospectively evaluated the use of daptomycin-based aminoglycoside-sparing combination therapy for the t...
Source: Journal of Chemotherapy - October 28, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Dalbavancin for infective endocarditis: a single centre experience.
We describe our experience with dalbavancin to complete the intravenous antibiotic regimen for difficult-to-treat IE cases due to gram-positive bacteria. We treated 10 severely ill patients, each presenting several comorbidities. Seven patients were microbiologically cured from IE, but two patients experienced IE relapse due to the same microrganism. Short-term mortality after dalbavancin was nil, but late mortality (within 1 year of hospital discharge) was 60%. No death was related to dalbavancin therapy. Treatment was generally well tolerated. Dalbavancin may be an option to complete IE treatment in selected cases...
Source: Journal of Chemotherapy - October 21, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Chemotherapeutic effects of MEK kinase inhibitor and BRAF kinase inhibitor on KRAS-mutated human colon cancer cell lines with different microsatellite instability.
Authors: Kim KO, Park WJ, Jung Y, Lee WS Abstract We analyzed responsiveness of KRAS-mutated CRC cell lines with distinctive MSI status against mitogen-activated protein kinase (MEK) inhibitor (selumetinib; AZD) and/or B-raf proto-oncogene (BRAF) kinase inhibitor (vemurafenib; PLX). The viability of MSI-high (MSI-H) KRAS-mutated LS174T cells treated with AZD or PLX was 24.5 ± 0.9% or 71.4 ± 3.6%, respectively, and the viability of microsatellite stable (MSS) KRAS-mutated SW480 cells for AZD or PLX was 57.4 ± 3.1% or 43.1 ± 1.8%, res...
Source: Journal of Chemotherapy - October 20, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Exploring metastatic breast cancer treatment changes during COVID-19 pandemic.
Authors: Fedele P, Ferro A, Sanna V, La Verde N, Paris I, Chiari R Abstract The emergency caused by COVID-19 pandemic has imposed a sudden reorganization of the healthcare structures and has created consequences in cancer patients management. General clinical recommendations for cancer patients were released, even if limited clinical cancer-specific data were available. A number of critical issues have come out during COVID-19 pandemic in the management of patients with metastatic breast cancer (MBC). To explore the changes in the treatment of patients with MBC during COVID-19 pandemic, we promoted a survey to the ...
Source: Journal of Chemotherapy - October 15, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Real world experience on maintenance chemotherapy with gemcitabine in second line setting for advanced non-small cell lung carcinoma.
Authors: Kwok WC, Lam DCL, Chiang KY, Ho JCM, Ip MSM, Tam TCC Abstract Maintenance chemotherapy was studied in first line setting for advanced stage non-small cell lung carcinoma (NSCLC). There has not been any data on the role of continuation maintenance chemotherapy in second line setting. A retrospective cohort study that included 226 patients with advanced stage NSCLC that received second line gemcitabine ± platinum was conducted. Patients who had continuation maintenance gemcitabine were compared with those who went on drug holiday. The primary endpoint was progression-free survival (PFS),...
Source: Journal of Chemotherapy - October 14, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

An analysis of totally implantable central venous port system infections in an urban tertiary referral center.
We examined the course of CVP-I including results of an antibiotic eradication attempt of CVP-BSI. We investigated adults with CVP-I from 2010 to 2018 who had to undergo port explantation or were treated by a combination of systemic antibiotics and antibiotic lock therapy (ALT). In nine years we diagnosed 206 CVP-I (CVP-LI: 52; CVP-BSI: 152). In 146 patients with CVP-I the port system was primary explanted, while 56 patients received antibiotics/ALT. 79% of Gram negative pathogens and 50% of coagulase negative staphylococci (CoNS) were eradicated. Failure of antibiotic treatment was more often associated with short time sp...
Source: Journal of Chemotherapy - October 10, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Ceftobiprole and pneumonia in adults admitted to the emergency department is it time to assess a new therapeutic algorithm?
CONCLUSIONS: This study confirms that ceftobiprole is effective in severely ill patients with pneumonia at risk of poor outcomes. PMID: 32996844 [PubMed - as supplied by publisher] (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - October 2, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Epidemiology and risk factors for healthcare-associated infections caused by Pseudomonas aeruginosa.
Authors: Folic MM, Djordjevic Z, Folic N, Radojevic MZ, Jankovic SM Abstract Pseudomonas aeruginosa (PA) is a globally recognized cause of healthcare-associated infections (HAIs). The aim of our cross-sectional study, conducted in a Serbian tertiary care hospital, was to investigate clinical characteristics of HAIs caused by the PA, the prevalence of various drug-resistant phenotypes of this pathogen, and risk factors for their occurrence. Prolonged ICU stay and previous carbapenem administration were independent risk factors for HAIs caused by carbapenem-resistant PA, while HAIs caused by multidrug-resistant PA we...
Source: Journal of Chemotherapy - October 2, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Antibacterial and antibiofilm activities of ceragenins against Achromobacter species isolated from cystic fibrosis patients.
In this study, the in vitro activities of various ceragenins against Achromobacter-species biofilms were investigated comparatively with a conventional antibiotic (meropenem). Biofilm-formation inhibition and biofilm-adhesion inhibition were investigated on five strong biofilm-producing strains. The lowest MIC50 result was obtained with CSA-13. All of the tested CSAs showed significant biofilm inhibitory activity in the manner of a time- and concentration-dependent effect. To the best of our knowledge, this is the first article to evaluate the antibacterial and antibiofilm activities of tested CSAs against Achromobact...
Source: Journal of Chemotherapy - September 29, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

In-house rapid colorimetric method for detection of ceftazidime/avibactam resistance in carbapenem resistant Enterobacterales.
Authors: Lora CV, Nastro M, Vay C, Famiglietti A, Rodríguez CH Abstract A rapid colorimetric method, the Andrade screening antimicrobial test, was compared with the E-test method to detect ceftazidime/avibactam (CZA) resistance in carbapenem resistant Enterobacterales clinical isolates. A 106 non-duplicated isolates (86 susceptible and 20 resistant to CZA) were chosen for validation. The sensitivity and specificity were 100%. This method investigates CZA resistance regardless of the resistance mechanism involved. It represents an economical and easy technique that can be applied to routine microbiology labor...
Source: Journal of Chemotherapy - September 21, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Active metronomic vinorelbine schedules decrease plasma interleukin-2 levels in mice with Lewis lung carcinoma.
In conclusion, our study confirmed the activity of mVNR in an immunocompetent model of lung carcinoma and suggest multiple mechanisms of action, including the modulation of IL-2 levels. PMID: 32930084 [PubMed - as supplied by publisher] (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - September 16, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Infective endocarditis by Acinetobacter species: a systematic review.
Authors: Ioannou P, Mavrikaki V, Kofteridis DP Abstract A. baumannii - A. calcoaceticus complex infections are increasingly frequent, especially in intensive care units. Such infections are associated with a mortality that can be as high as 62%. On the other hand, infective endocarditis (IE) is an uncommon disease with notable morbidity and mortality. Even though IE is rarely caused by Acinetobacter species, these infections can be particularly problematic due to increasing antimicrobial resistance. The purpose of this study was to systemically review all published cases of IE by Acinetobacter species in the litera...
Source: Journal of Chemotherapy - September 4, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Community-acquired pneumonia: aetiology, antibiotic resistance and prospects of phage therapy.
Authors: Sheam MM, Syed SB, Nain Z, Tang SS, Paul DK, Ahmed KR, Biswas SK Abstract Bacteria are the most common aetiological agents of community-acquired pneumonia (CAP) and use a variety of mechanisms to evade the host immune system. With the emerging antibiotic resistance, CAP-causing bacteria have now become resistant to most antibiotics. Consequently, significant morbimortality is attributed to CAP despite their varying rates depending on the clinical setting in which the patients being treated. Therefore, there is a pressing need for a safe and effective alternative or supplement to conventional antibiotics. B...
Source: Journal of Chemotherapy - August 23, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Prevalence of leukoencephalopathy and its potential cognitive sequelae in cancer patients.
Authors: Schroyen G, Meylaers M, Deprez S, Blommaert J, Smeets A, Jacobs S, Sunaert S, Sleurs C, Uyttebroeck A Abstract Due to the rising use of chemotherapy treatment in cancer patients and growing survival rates, therapy-induced neurotoxic side effects are increasingly reported. Given the ambiguity about the prevalence and severity of leukoencephalopathy, one of such toxic side effects, in non-central nervous system (CNS) cancer patients, we performed a systematic literature search using the PubMed/Medline database to summarize existing literature regarding leukoencephalopathy epidemiology in non-CNS cancer patie...
Source: Journal of Chemotherapy - August 19, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Optimization of tigecycline dosage regimen for different infections in the patients with hepatic or renal impairment.
The objective of this study was to investigate the cumulative fraction of response (CFR) of various tigecycline dosing regimens in patients with hepatic or renal impairment. METHODS: Monte Carlo simulations were performed using pharmacokinetic parameters and microbiological data to evaluate various tigecycline regimens in patients with hepatic or renal impairment. RESULTS: For HAP and cIAI, the regimen of 25 mg q12h achieved CFR values of>90% in Child-Pugh C patients against Gram-positive bacteria and partial Gram-negative bacteria (Escherichia coli and Klebsiella oxytoca). However, dose increases of tige...
Source: Journal of Chemotherapy - August 13, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Gram-negative bacteria as causative agents of ventilator-associated pneumonia and their respective resistance mechanisms.
Authors: Bandić-Pavlović D, Zah-Bogović T, Žižek M, Bielen L, Bratić V, Hrabač P, Slačanac D, Mihaljević S, Bedenić B Abstract Ventilator-associated pneumonia (VAP) is a serious and common complication in patients admitted to intensive care unit (ICU) and contributes to mortality. Multidrug Gram-negative bacteria such as Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae are frequently associated with VAP in ICU. A prospective study was set up in three ICUs of the University Hospital Center Zagreb and one ICU in General Hospital Pula from September 2017 to March 2018. Antibiotic su...
Source: Journal of Chemotherapy - August 1, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Optimal vancomycin dose in the treatment of Clostridium difficile infection, antimicrobial stewardship initiative.
Authors: Ereshefsky BJ, Alrahmany D, El Nekidy WS, Pontiggia L, Ghazi IM Abstract C. difficile infections (CDI) are increasingly recognized as a leading cause of infectious diarrhea, with increasing morbidity and mortality. Treatment primarily centers around oral vancomycin treatment. A wide range of dosing regimens exist in clinical practice, with little evidence to help distinguish the therapeutic benefit between them. This is a retrospective cohort study conducted at an academic medical center that enrolled adult patients admitted with CDI. The primary outcome was a composite of complete or partial cure at the e...
Source: Journal of Chemotherapy - July 29, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

A snapshot survey of antimicrobial susceptibility among respiratory Staphylococcus aureus isolates: focus on ceftaroline.
Authors: Oliveira DS, Carniel E, Perez LRR PMID: 32715970 [PubMed - as supplied by publisher] (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - July 29, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Compliance with South Africa's Antimicrobial Resistance National Strategy Framework: are we there yet?
CONCLUSION: Although some facilities complied well with the Framework, overall compliance was sub-optimal. With the introduction of universal healthcare in South Africa, coupled with growing AMR rates, ongoing initiatives to actively implement the Framework should be targeted at non-compliant facilities. PMID: 32693710 [PubMed - as supplied by publisher] (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - July 24, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

A systematic review of implications, mechanisms, and stability of in  vivo emergent resistance to colistin and tigecycline in Acinetobacter baumannii.
A systematic review of implications, mechanisms, and stability of in vivo emergent resistance to colistin and tigecycline in Acinetobacter baumannii. J Chemother. 2020 Jul 17;:1-11 Authors: Karakonstantis S Abstract The potential of A. baumannii for acquired resistance to last resort antibiotics (colistin and tigecycline) during treatment has important clinical implications, especially when dealing with patients failing to improve despite treatment with an active antimicrobial. However, the relevant literature remains scattered. Therefore, a systematic search was conducted in PubMed and Scopus. Se...
Source: Journal of Chemotherapy - July 19, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Management of antibiotic-resistant Helicobacter pylori infection: current perspective in Iran.
Authors: Alihosseini S, Ghotaslou R, Heravi FS, Ahmadian Z, Leylabadlo HE Abstract Helicobacter pylori is a common gastric bacterial pathogen implicated in the pathogenesis of many digestive tract disorders. H. pylori infection prevalence has been reported alarmingly in Iran. A plethora of studies have been conducted to evaluate the efficiency of first-line and second-line eradication attempts in patients diagnosed with H. pylori infections in Iran. The present study, was evaluated the efficacy of first-line and second-line therapy in H. pylori infections in Iran. We aimed to consider the literature review of the v...
Source: Journal of Chemotherapy - July 14, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Correction.
Authors: PMID: 32650707 [PubMed - as supplied by publisher] (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - July 13, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

The role of PK/PD-based strategies to preserve new molecules against multi-drug resistant gram-negative strains.
Authors: Adembri C, Cappellini I, Novelli A PMID: 32628094 [PubMed - as supplied by publisher] (Source: Journal of Chemotherapy)
Source: Journal of Chemotherapy - July 7, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Docetaxel-induced acute myositis: a case report with review of literature.
Authors: Wongsaengsak S, Quirch M, Ball S, Sultan A, Jahan N, Elmassry M, Rehman S Abstract Docetaxel is an anti-microtubule agent and a highly effective treatment of locally advanced and metastatic breast cancer. There are several adverse effects associated with docetaxel, such as myelosuppression, peripheral neuropathy, fluid retention, and asthenia. One of the most well-known side-effects of this medication is mild to moderate myalgia. Here, we report a case of a 49-year-old female with stage 3 breast cancers who developed severe acute myositis following docetaxel use. The mechanism of docetaxel-induced myositis...
Source: Journal of Chemotherapy - July 4, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research

Roseomonas species infections in humans: a systematic review.
Authors: Ioannou P, Mavrikaki V, Kofteridis DP Abstract Roseomonas species have been recognized to cause infections in immunocompromised individuals. The purpose of this study was to systemically review all published cases of Roseomonas infections in humans and describe the epidemiology, microbiology, antimicrobial susceptibility, treatment and outcomes of these infections in humans. We performed a systematic review of PubMed (through 20th Octrober 2019) for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of Roseomonas species infections. A total of 37 studies, co...
Source: Journal of Chemotherapy - July 4, 2020 Category: Cancer & Oncology Tags: J Chemother Source Type: research