New drugs for NAFLD: lessons from basic models to the clinic
AbstractThe term nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of increasingly harmful conditions ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) to liver fibrosis and end-stage cirrhosis. NAFLD is the currently most common form of chronic liver disease in both adults and children worldwide. As NAFLD evolves as a global pandemic alongside the still growing prevalence of metabolic syndrome, obesity, and diabetes, it is inevitable to develop effective counterstrategies. Over the last decades, great effort has been dedicated to the understanding of the pathogenesis of NAFLD....
Source: Hepatology International - December 4, 2019 Category: Infectious Diseases Source Type: research

Targeting adenosinergic pathway enhances the anti-tumor efficacy of sorafenib in hepatocellular carcinoma
ConclusionsThese results suggest that adenosinergic pathway might represent an applicable target for sorafenib-combined-therapies in human HCC. (Source: Hepatology International)
Source: Hepatology International - December 4, 2019 Category: Infectious Diseases Source Type: research

Retrospective comparison of EASL 2018 and LI-RADS 2018 for the noninvasive diagnosis of hepatocellular carcinoma using magnetic resonance imaging
ConclusionsOn ECA-MRI, the LR-5 category of LI-RADS 2018 provides better sensitivity and accuracy than the EASL 2018 for diagnosing HCC. EASL 2018 provides comparable diagnostic performances between ECA-MRI and HBA-MRI, but the LR-5 category of LI-RADS 2018 provides better sensitivity on ECA-MRI than on HBA-MRI. (Source: Hepatology International)
Source: Hepatology International - December 4, 2019 Category: Infectious Diseases Source Type: research

Antimicrobial resistance in chronic liver disease
AbstractHigh levels of antimicrobial drug resistance deleteriously affecting the outcome of treatment with antibacterial agents are causing increasing concern worldwide. This is particularly worrying in patients with cirrhosis with a depressed immune system and heightened susceptibility to infection. Antibiotics have to be started early before results of microbiological culture are available. Current guidelines for the empirical choice of antibiotics in this situation are not very helpful, and embracing antimicrobial stewardship including rapid de-escalation of therapy are not sufficiently emphasised. Multi-drug resistant ...
Source: Hepatology International - December 3, 2019 Category: Infectious Diseases Source Type: research

TAF and TDF attenuate liver fibrosis through NS5ATP9, TGF β1/Smad3, and NF-κB/NLRP3 inflammasome signaling pathways
ConclusionsTAF/TDF prevented progression and promoted reversion of liver fibrosis through assembling TGF β1/Smad3 and NF-κB/NLRP3 inflammasome signaling pathways via upregulating the expression of NS5ATP9. TAF/TDF also regulated the differentiation, activation, and proliferation of HSCs. The findings provided strong evidence for the role of TAF/TDF as a new promising therapeutic strategy in liver fib rosis. (Source: Hepatology International)
Source: Hepatology International - November 22, 2019 Category: Infectious Diseases Source Type: research

Change in antibiotic regimen for emerging multidrug resistance in nosocomial ascitic fluid infection
Graphic abstract (Source: Hepatology International)
Source: Hepatology International - November 21, 2019 Category: Infectious Diseases Source Type: research

Sarcopenia: an emerging risk factor for non-alcoholic fatty liver disease
(Source: Hepatology International)
Source: Hepatology International - November 21, 2019 Category: Infectious Diseases Source Type: research

Use of HBsAg quantification in the natural history and treatment of chronic hepatitis B
AbstractIn patients with chronic hepatitis B (CHB) infection, it is important to monitor the natural history, assess treatment response, and predict the risk of liver-related complications. Quantification of serum hepatitis B surface antigen (HBsAg) has gained wide interests since the last decade. It is secreted from hepatocytes in both hepatitis B e antigen (HBeAg)-positive and HBeAg-negative phases of the disease, and can be transcribed and translated from different sources of viral genome [ccc DNA or integrated hepatitis B virus (HBV) DNA]. In untreated patients, it declines slowly through the natural course and remains...
Source: Hepatology International - November 19, 2019 Category: Infectious Diseases Source Type: research

Sarcopenia and fatty liver disease
AbstractNon-alcoholic fatty liver disease (NAFLD) is the most common liver disease which may progress to non-alcoholic steatohepatitis. The prevalence of sarcopenia, which is the loss of muscle mass and strength, is increasing in the aging society. Recent studies reported the relationship between NAFLD and sarcopenia. The skeletal muscle is the primary organ for glucose disposal. Loss of muscle mass can cause insulin resistance, which is an important risk factor for NAFLD. Moreover, obesity, chronic low-grade inflammation, vitamin D deficiency, physical inactivity, hepatokines, and myokines might be involved in the pathoph...
Source: Hepatology International - November 8, 2019 Category: Infectious Diseases Source Type: research

Hepatocellular carcinoma and non-alcoholic fatty liver disease
This article reviews the most updated information about NAFLD-related HCC and provides some insight into strategies that must be considered to reduce its potential disease burden. (Source: Hepatology International)
Source: Hepatology International - November 7, 2019 Category: Infectious Diseases Source Type: research

Circulating tumor cells are associated with poor outcomes in early-stage hepatocellular carcinoma: a prospective study
AbstractBackgroundPrevious studies evaluating association between circulating tumor cells (CTCs) and clinical outcomes in hepatocellular carcinoma (HCC) have shown inconsistent results due to suboptimal detection methods and patient heterogeneity.MethodsPatients undergoing surgery for early-stage HCC were prospectively enrolled. The CTC numbers were determined using a tapered slit platform, which detects CTCs based on the cell size and morphology. Survival and recurrence were evaluated, and Cox proportional hazards models were used to demonstrate the prognostic significance of CTC.ResultsOf 105 patients, 25 had increased C...
Source: Hepatology International - November 5, 2019 Category: Infectious Diseases Source Type: research

Comparison of HBsAg changes between HBeAg-negative patients who discontinued or maintained entecavir therapy
AbstractBackground/purposeThe study compared the hepatitis B surface antigen (HBsAg) changes between hepatitis B e antigen (HBeAg)-negative non-cirrhotic chronic hepatitis B patients who discontinued or maintained entecavir therapy.MethodsA total of 250 HBeAg-negative, non-cirrhotic patients who were treated with entecavir previously and had stopped treatment for at least 12  months (discontinued group) and 231 HBeAg-negative, non-cirrhotic patients who had received entecavir treatment for at least 4 years (maintained group) were recruited.ResultsIn the discontinued group, 71 had a persistent virological suppress...
Source: Hepatology International - October 24, 2019 Category: Infectious Diseases Source Type: research

Complications constitute a major risk factor for mortality in hepatitis B virus-related acute-on-chronic liver failure patients: a multi-national study from the Asia –Pacific region
ConclusionThe presence of complications is a major risk factor for mortality in HBV –ACLF patients. TPPM possesses high predictive ability in HBV–ACLF patients, especially in cirrhotic HBV–ACLF patients. (Source: Hepatology International)
Source: Hepatology International - October 24, 2019 Category: Infectious Diseases Source Type: research

MicroRNA-744/transforming growth factor β1 relationship regulates liver cirrhosis
ConclusionsMiR-744-led suppression in HSC activation is most likely through TGF β1 because exogenous TGFβ1 nearly negated miR-744 Agomir’s action. This study suggests that reduction of miR-744 is a reliable biomarker for LC and miR-744/TGFβ1 relationship is a key regulator of LC. (Source: Hepatology International)
Source: Hepatology International - October 23, 2019 Category: Infectious Diseases Source Type: research

Correction to: Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update
The article Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update, written by [Shiv Sarin], was originally published electronically on the publisher ’s internet portal (currently SpringerLink) on June 06, 2019 without open access. (Source: Hepatology International)
Source: Hepatology International - October 9, 2019 Category: Infectious Diseases Source Type: research

Refining the role of epicardial adipose tissue in non-alcoholic fatty liver disease
(Source: Hepatology International)
Source: Hepatology International - October 4, 2019 Category: Infectious Diseases Source Type: research

Finite nucleos(t)ide analog therapy in HBeAg-negative chronic hepatitis B: an emerging paradigm shift
AbstractPotent nucleos(t)ide analogs (NUC), such as entecavir and tenofovir disoproxil fumarate, are able to suppress HBV DNA to undetectable level. These agents have no direct action on cccDNA, which is a very stable template for HBV production, hence long-term or even life-long NUC therapy is required in HBeAg-negative patients to maintain HBV suppression and to achieve the ultimate goal of HBsAg loss. However, there are concerns of indefinite or life-long NUC therapy, including drug resistance, financial burden, adherence and willingness for indefinite long-term NUC therapy. Patients lost to follow-up and hence, not mon...
Source: Hepatology International - September 26, 2019 Category: Infectious Diseases Source Type: research

Non-obese histologically confirmed NASH patients with abnormal liver biochemistry have more advanced fibrosis
AbstractBackground and aimsNon-alcoholic fatty liver disease (NAFLD) commonly affects subjects with obesity, yet non-obese NAFLD is increasingly being recognized. We aimed to investigate the clinicopathological and genetic characteristics of non-obese NAFLD patients.MethodsThe clinical, histological and genetic data of 84 NAFLD patients with biopsy for abnormal liver function test were reviewed. Both NAS-CRN and SAF scoring systems were applied for histopathological evaluation.PNPLA3 andTMS6F2 genotyping were also performed.ResultsAll of the 84 patients were histologically diagnosed with non-alcoholic steatohepatitis (NASH...
Source: Hepatology International - September 26, 2019 Category: Infectious Diseases Source Type: research

Epidemiology and clinical course of primary biliary cholangitis in the Asia –Pacific region: a systematic review and meta-analysis
ConclusionIn the Asia –Pacific region, the prevalence and incidence of PBC are higher than once expected. PBC tends to be diagnosed at older age and has a relatively low incidence of HCC in this region.Graphic abstract (Source: Hepatology International)
Source: Hepatology International - September 25, 2019 Category: Infectious Diseases Source Type: research

APASL HCV guidelines of virus-eradicated patients by DAA on how to monitor HCC occurrence and HBV reactivation
AbstractIn the direct-acting antiviral (DAA) era for hepatitis C virus (HCV) infection, sustained virological response (SVR) is very high, but close attention must be paid to the possible occurrence of hepatocellular carcinoma (HCC) and reactivation of hepatitis B virus (HBV) in patients with co-infection who achieved SVR in short term. HCC occurrence was more often observed in patientswith previous HCC history. We found occurrence of HCC in 178 (29.6%) of 602 patientswith previous HCC history (15.4  months mean follow-up post-DAA initiation) but, in contrast, in only 604 (1.3%) of 45,870 patientswithout previous HCC ...
Source: Hepatology International - September 20, 2019 Category: Infectious Diseases Source Type: research

Treatment with carvedilol improves survival of patients with acute-on-chronic liver failure: a randomized controlled trial
ConclusionsIn ACLF patients with either no or small esophageal varices and HVPG  ≥ 12 mmHg, carvedilol leads to improved survival and fewer AKI and SBP events up to 28 days.ClinicalTrials.gov identifier numberNCT02583698. (Source: Hepatology International)
Source: Hepatology International - September 20, 2019 Category: Infectious Diseases Source Type: research

Clinical and morpho-molecular classifiers for prediction of hepatocellular carcinoma prognosis and recurrence after surgical resection
This study aimed to identify clinicopathological characteristics and molecular markers to establish classifiers to predict the 5-year overall survival (OS) and the 3-year recurrence in HCC patients post-operatively.MethodsWe enrolled 647 HCC patients from two institutions, underwent surgical resection and divided the patients into one training and two validation cohorts. Clinicopathologic characteristics and tumor protein expression of 29 biomarkers by immunohistochemical (IHC) analysis were used to develop and validate a prognostic and  a recurrent classifier, using the maximum relevance minimum redundancy algor...
Source: Hepatology International - September 17, 2019 Category: Infectious Diseases Source Type: research

Cellular and functional loss of liver endothelial cells correlates with poor hepatocyte regeneration in acute-on-chronic liver failure
AbstractBackground and aimAcute hepatic insult triggers regeneration. If acute-on-chronic liver failure (ACLF) patients have a poorer regenerative response than acute liver failure (ALF) patients, and if so, the mechanisms underlying this, are not well understood.MethodsWe investigated the status of hepatocyte proliferation, hepatic progenitor cell (HPC) mediated regeneration, non-parenchymal cells (through immunohistochemistery), cytokines and growth factors (cytokine bead array) in liver and peripheral blood of ACLF (n = 29) and ALF (n = 17) patients. Liver endothelial cells, mesenchymal cells...
Source: Hepatology International - September 12, 2019 Category: Infectious Diseases Source Type: research

Generic sofosbuvir/ledipasvir for the treatment of genotype 4 chronic hepatitis C in Egyptian children (9 –12 years) and adolescents
ConclusionThe generic SOF/LED fixed-dose combination is safe and effective in children, 9 –12 years, and adolescents with vRVR rate of 96%, 100% EOT response and SVR12. (Source: Hepatology International)
Source: Hepatology International - September 12, 2019 Category: Infectious Diseases Source Type: research

Significant decrease in Faecalibacterium among gut microbiota in nonalcoholic fatty liver disease: a large BMI- and sex-matched population study
ConclusionsThe significant decrease inFaecalibacterium is a remarkable characteristic on BMI- and sex-matched analysis in NAFLD participants in a large study population. The decrease inFaecalibacterium is related to the pathogenesis of NAFLD. (Source: Hepatology International)
Source: Hepatology International - September 12, 2019 Category: Infectious Diseases Source Type: research

Preoperative transcatheter arterial chemoembolization for surgical resection of huge hepatocellular carcinoma ( ≥ 10 cm): a multicenter propensity matching analysis
ConclusionPreoperative TACE did not increase perioperative morbidity or mortality, yet was associated with an improved OS and RFS after liver resection of huge HCC ( ≥ 10 cm). (Source: Hepatology International)
Source: Hepatology International - September 5, 2019 Category: Infectious Diseases Source Type: research

Radiomics in hepatocellular carcinoma: a quantitative review
AbstractRadiomics is an emerging field which extracts quantitative radiology data from medical images and explores their correlation with clinical outcomes in a non-invasive manner. This review aims to assess whether radiomics is a useful and reproducible method for clinical management of hepatocellular carcinoma (HCC) by reviewing the strengths and weaknesses of current radiomics literature pertaining specifically to HCC. From an initial set of 48 articles recovered through database searches, 23 articles were retained to be included in this review after full screening. Among these 23 studies, 7 used a radiomics approach i...
Source: Hepatology International - August 31, 2019 Category: Infectious Diseases Source Type: research

Pediatric non-cirrhotic portal fibrosis: role of endoscopic management in determining long-term outcome
ConclusionsOverall, endoscopic outcome of NCPF is favorable. One-third patients have recurrence of esophageal varices. Small proportion of bleeders have poor outcome. (Source: Hepatology International)
Source: Hepatology International - August 29, 2019 Category: Infectious Diseases Source Type: research

Direct-acting antivirals in East Asian hepatitis C patients: real-world experience from the REAL-C Consortium
This study addressed the real-world status of direct-acting antiviral (DAA) therapy among patients from East Asia.MethodsChronic hepatitis C (CHC) patients from clinical sites in Japan, Taiwan, South Korea, and Hong Kong were recruited in the REAL-C registry, an observational chart review registry. The primary outcome was sustained virologic response (SVR12, HCV RNA PCR  
Source: Hepatology International - August 28, 2019 Category: Infectious Diseases Source Type: research

Wnt status-dependent oncogenic role of BCL9 and BCL9L in hepatocellular carcinoma
ConclusionOncogenic BCL9 proteins represent promising targets for cancer therapy and inhibiting them may be particularly beneficial in Wnt-inactive HCCs.Graphic abstract (Source: Hepatology International)
Source: Hepatology International - August 22, 2019 Category: Infectious Diseases Source Type: research

Association of epicardial adipose tissue with non-alcoholic fatty liver disease: a meta-analysis
AbstractBackgroundIncreased epicardial adipose tissue (EAT) has been proposed as a risk factor for non-alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the association of EAT with NAFLD.MethodsThe PubMed, EMBASE, and Cochrane databases were systematically reviewed by two independent investigators to identify relevant studies assessing the association of EAT thickness (EAT-t) and volume (EAT-v) with NAFLD. Comparisons between NAFLD subjects and controls were performed with meta-analysis and trial sequential analysis (TSA).ResultsA total of thirteen case –control studies (n =&thins...
Source: Hepatology International - August 20, 2019 Category: Infectious Diseases Source Type: research

The change in the nationwide seroprevalence of hepatitis C virus and the status of linkage to care in South Korea from 2009 to 2015
ConclusionsAnti-HCV prevalence in South Korea was 0.6% in 2015, showing a 30% decrease from that in 2009. Although the HCV RNA testing rate was increased since 2009, this remains suboptimal. Moreover, the treatment uptake rate should be improved in South Korea. (Source: Hepatology International)
Source: Hepatology International - August 20, 2019 Category: Infectious Diseases Source Type: research

Prognostic four-gene signature for overall survival in patients with hepatocellular carcinoma
(Source: Hepatology International)
Source: Hepatology International - August 16, 2019 Category: Infectious Diseases Source Type: research

Asparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis
ConclusionAsparaginase is a common cause of antineoplastic-induced liver injury with jaundice, typically with short latency, marked steatosis, and prolonged jaundice, which can lead to delays in antileukemic therapy. The cause of injury is likely direct inhibition of hepatic protein synthesis caused by asparagine depletion. (Source: Hepatology International)
Source: Hepatology International - August 7, 2019 Category: Infectious Diseases Source Type: research

Association between neutrophil –lymphocyte ratio, socioeconomic status, and ethnic minority with treatment outcome in hepatocellular carcinoma
AbstractBackgroundPatients with lower socioeconomic status (SES), ethnic minorities and elevated neutrophil –lymphocyte ratio (NLR) have been suggested to have worse outcomes in hepatocellular carcinoma (HCC). However, how changes in NLR after intervention relate to survival has not been elucidated.ObjectivesWe evaluated the association of NLR with overall survival (OS) and progression-free survival (PFS) in a large institutional cohort of HCC.MethodsWe reviewed all patients diagnosed with HCC between 2005 –2016. The association between elevated NLR (>  4) and survival was examined with univariable an...
Source: Hepatology International - August 1, 2019 Category: Infectious Diseases Source Type: research

Reversal of NASH fibrosis with pharmacotherapy
AbstractNAFLD is a spectrum of liver disease starting with fatty liver at one end of the spectrum and cirrhosis or liver cancer at the other end. Worldwide, NAFLD has become one of the most common liver diseases and it has also become one of the leading indications for liver transplantation. Our understanding of the NAFLD epidemiology, pathogenesis and its progression to cirrhosis has improved over the last 2 decades. Currently, however, there are no FDA-approved treatment options for fibrosis resulting from NAFLD. A number of compounds targeting multiple pathways involved in the progression of NAFLD are currently in phase...
Source: Hepatology International - July 30, 2019 Category: Infectious Diseases Source Type: research

Clinical immunology and immunotherapy for hepatocellular carcinoma: current progress and challenges
AbstractAt the time of hepatocellular carcinoma (HCC) diagnosis, patients are most often at an advanced stage; however, the current treatment regimens remain unsatisfactory. Thus, novel and more powerful therapeutic approaches for advanced HCC are urgently required. Exacerbation of immunotolerant signals and/or escaping immunosurveillance leads to the development of HCC, which appears to be a rational reason to use immunotherapy to restore anticancer immunity. Several novel immunotherapeutic methods, including the use of immune checkpoint inhibitors, new types of immune cell adoption [e.g., chimeric antigen receptor T cell...
Source: Hepatology International - July 27, 2019 Category: Infectious Diseases Source Type: research

An imbalance between stellate cells and γδT cells contributes to hepatocellular carcinoma aggressiveness and recurrence
ConclusionsThe peritumoral SGR is related to aggressive tumor behavior and has a powerful predictive value in HCC. Early recurrence in patients with a high peritumoral SGR might be associated with high CTC levels. (Source: Hepatology International)
Source: Hepatology International - July 24, 2019 Category: Infectious Diseases Source Type: research

Identification and validation of a prognostic four-genes signature for hepatocellular carcinoma: integrated ceRNA network analysis
AbstractBackgroundHepatocellular carcinoma (HCC) is one of the most aggressive malignant tumors, with a poor long-term prognosis worldwide. The functional deregulations of global transcriptome were associated with the genesis and development of HCC, but lacks systematic research and validation.MethodsA total of 519 postoperative HCC patients were included. We built an interactive and visual competing endogenous RNA network. The prognostic signature was established with the least absolute shrinkage and selection operator algorithm. Multivariate Cox regression analysis was used to screen for independent prognostic factors fo...
Source: Hepatology International - July 18, 2019 Category: Infectious Diseases Source Type: research

The first Chinese guidelines on the Management of Ascites and its Related Complications in Cirrhosis: a great goal for a great country
(Source: Hepatology International)
Source: Hepatology International - July 16, 2019 Category: Infectious Diseases Source Type: research

Bacteroides in colonic mucosa-associated microbiota affects the development of minimal hepatic encephalopathy in patients with cirrhosis
ConclusionsThe decrease in microbial diversity andgenus Bacteroides in MAM is a risk factor for MHE in patients with liver cirrhosis. (Source: Hepatology International)
Source: Hepatology International - July 9, 2019 Category: Infectious Diseases Source Type: research

Relationship between relative skeletal muscle mass and nonalcoholic fatty liver disease: a systematic review and meta-analysis
ConclusionsSMI level in patients with NAFLD was lower than healthy people, and patients with sarcopenia have higher occurrence risk of NAFLD, as well as its advanced stages including NASH or NAFLD-related significant fibrosis. Further well-designed prospective studies are required to strengthen the arguments. (Source: Hepatology International)
Source: Hepatology International - July 9, 2019 Category: Infectious Diseases Source Type: research

Prediction and clinical implications of HBV reactivation in lymphoma patients with resolved HBV infection: focus on anti-HBs and anti-HBc antibody titers
AbstractHepatitis B virus (HBV) reactivation (HBV-R) and hepatitis related to HBV-R are well-recognized complications that occur in patients who have undergone cytotoxic chemotherapy or immunosuppressive therapy. The degree of HBV-R in this population varies from self-limited or asymptomatic hepatitis to acute liver failure, which may lead to life-threatening events. However, no established treatment or standard surveillance method exists for monitoring patients to predict the development of HBV-R during or after chemotherapy or immunosuppressive therapy, particularly regarding resolved HBV infection. Prophylactic antivira...
Source: Hepatology International - July 9, 2019 Category: Infectious Diseases Source Type: research

Ascitic fluid infection in children with liver disease: time to change empirical antibiotic policy
ConclusionsAFI was found in 31% children with liver disease and almost half of them were nosocomial resulting in high mortality. ESBL producing Gram-negative bacteria were the most frequently isolated organisms. Cefoperazone –sulbactam or carbapenems may be useful empirical antibiotics in nosocomial setting. Children with AFI and CPT score ≥ 11 should be evaluated for liver transplantation. (Source: Hepatology International)
Source: Hepatology International - July 9, 2019 Category: Infectious Diseases Source Type: research

The prognostic role of liver stiffness in patients with chronic liver disease: a systematic review and dose –response meta-analysis
ConclusionsThe dose –response meta-analysis presents a combination between the levels of baseline LS and RRs for each clinically relevant outcome. TE, which is noninvasive, might be a novel strategy for risk stratification and identification of patients at high risk of developing these outcomes. (Source: Hepatology International)
Source: Hepatology International - July 4, 2019 Category: Infectious Diseases Source Type: research

Hepatology through the crystal ball
AbstractThe rapidity of the increase in the global burden of liver disease covered in this review with estimates worldwide of 2 million deaths from cirrhosis and with no signs of effective controls being introduced for two of the main causes, namely, excess alcohol consumption and obesity, is of great concern. The 25% prevalence of non-alcoholic fatty liver disease in many population groups and the recent description of primary hepatocellular cancer (HCC) in obese subjects without underlying severe fibrosis/cirrhosis also raises many questions. In addition, covered in this review are more encouraging areas including techni...
Source: Hepatology International - July 4, 2019 Category: Infectious Diseases Source Type: research

CCN2 –MAPK–Id-1 loop feedback amplification is involved in maintaining stemness in oxaliplatin-resistant hepatocellular carcinoma
ConclusionsCCN2/MAPK/Id-1 loop feedback amplification is involved in oxaliplatin resistance, and the combination of oxaliplatin with inhibitor of CCN2 or MAPK signaling could provide a promising approach to ameliorating oxaliplatin resistance in HCC. (Source: Hepatology International)
Source: Hepatology International - June 27, 2019 Category: Infectious Diseases Source Type: research

Prognostic subclass of intrahepatic cholangiocarcinoma by integrative molecular –clinical analysis and potential targeted approach
ConclusionsTwo molecular subtypes of iCCA with distinct clinicopathological differences were identified. Knowledge of clinical and pathologic characteristics can predict molecular subtypes, and knowledge of different subtype signaling pathways may lead to more rational, targeted approaches to treatment. (Source: Hepatology International)
Source: Hepatology International - June 18, 2019 Category: Infectious Diseases Source Type: research

SHG/TPEF-based image technology improves liver fibrosis assessment of minimally sized needle biopsies
ConclusionsThe use of SHG/TPEF-based image technology may give useful suggestive information in evaluation of CHB-related liver fibrosis for the short sample (biopsy length  >  0.5 cm). (Source: Hepatology International)
Source: Hepatology International - June 11, 2019 Category: Infectious Diseases Source Type: research

Long-term virological and serologic responses of chronic hepatitis B virus infection to tenofovir disoproxil fumarate-containing regimens in patients with HIV and hepatitis B coinfection
ConclusionsTDF-containing cART achieved durable HBV viral suppression in HIV/HBV-coinfected patients and HBeAg positivity at baseline was associated with failure to achieve HBV suppression despite long-term TDF-containing cART. (Source: Hepatology International)
Source: Hepatology International - June 8, 2019 Category: Infectious Diseases Source Type: research