A non-invasive model based on the virtual portal pressure gradient to predict the first variceal hemorrhage in cirrhotic patients
ConclusionsThe vPPG-based nomogram could be used for risk stratification of the first VH in patients with cirrhosis. (Source: Hepatology International)
Source: Hepatology International - May 18, 2022 Category: Infectious Diseases Source Type: research

Unsolved issues in treatment for grey zone chronic hepatitis B patients
(Source: Hepatology International)
Source: Hepatology International - May 17, 2022 Category: Infectious Diseases Source Type: research

The promise of artificial intelligence for predictive biomarkers in hepatology
(Source: Hepatology International)
Source: Hepatology International - May 16, 2022 Category: Infectious Diseases Source Type: research

Automated fibrosis phenotyping of liver tissue from non-tumor lesions of patients with and without hepatocellular carcinoma after liver transplantation for non-alcoholic fatty liver disease
ConclusionIn patients who underwent liver transplantation, fibrotic histological phenotypes in non-tumor lesions appeared to be different between HCC and non-HCC. Phenotypic analysis of collagen in non-tumor lesions might be an effective and automated method to distinguish HCC from non-HCC on histopathology imaging. (Source: Hepatology International)
Source: Hepatology International - May 13, 2022 Category: Infectious Diseases Source Type: research

Reply to: The best predictive model for post-SVR HCC: can it be universal?
(Source: Hepatology International)
Source: Hepatology International - May 12, 2022 Category: Infectious Diseases Source Type: research

Actin-related protein 2/3 complex subunit 2-enriched extracellular vesicles drive liver cancer metastasis
ConclusionThis study reveals previously unreported expression and function of ARPC2 in EVs. EVs with highly expressed ARPC2 enhance cancer cell growth and metastasis. ARPC2 may provide a prospective target for the novel treatment of HCC patients.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - May 12, 2022 Category: Infectious Diseases Source Type: research

Benefit of adjuvant radiotherapy for gallbladder cancer: a comparability-based meta-analysis
ConclusionART not only showed benefits in patients with a similar clinical profile to those treated without ART but also yielded comparable survival in patients with an inferior clinical profile. Our results suggest the more active application of ART in GBC treatment.Protocol registrationThis study is registered in PROSPERO (CRD42021240624, available at:https://www.crd.york.ac.uk/). (Source: Hepatology International)
Source: Hepatology International - May 9, 2022 Category: Infectious Diseases Source Type: research

Tumor –matrix interaction induces phenotypic switching in liver cancer cells
ConclusionsLiver cancer cell –matrix interaction induces cholangiocytic differentiation and switches liver cancer cells from a proliferative to an invasive phenotype through the Src/MAPK pathway, which may partly explain the differences in the behaviors of HCC and ICC. (Source: Hepatology International)
Source: Hepatology International - May 7, 2022 Category: Infectious Diseases Source Type: research

The banned herbal medicine induced liver injury in Taiwan
(Source: Hepatology International)
Source: Hepatology International - April 28, 2022 Category: Infectious Diseases Source Type: research

Randomised clinical trial: effect of adding branched chain amino acids to exercise and standard-of-care on muscle mass in cirrhotic patients with sarcopenia
ConclusionAddition of BCAA to exercise, dietary counselling and standard medical therapy did not improve muscle mass in patients with cirrhosis having sarcopenia. (CTRI/2019/05/019269).Trial registration numberCTRI/2019/05/019269 (Clinical Trials Registry of India). (Source: Hepatology International)
Source: Hepatology International - April 25, 2022 Category: Infectious Diseases Source Type: research

Renal safety of tenofovir disoproxil fumarate and entecavir in liver transplant patients: a nationwide Korean registry study
ConclusionsIn this nationwide study, the use of TDF was associated with an increased risk of renal dysfunction, when compared with ETV. (Source: Hepatology International)
Source: Hepatology International - April 23, 2022 Category: Infectious Diseases Source Type: research

Ultrasonic spleen thickness-based indexes surpass Baveno VI criteria in high-risk gastroesophageal varices detection
ConclusionsSPA, without LSM, improves HRGOV detection comparing with BVI. UST based algorithms combination can achieve the best efficiency especially in sustained virus response hepatitis B. (Source: Hepatology International)
Source: Hepatology International - April 12, 2022 Category: Infectious Diseases Source Type: research

Safety and immunogenicity of SARS-CoV-2 vaccines in Chinese patients with cirrhosis: a prospective multicenter study
ConclusionsInactivated COVID-19 vaccinations are safe with acceptable immunogenicity in cirrhotic patients, and Child –Pugh score of B and C levels is associated with hyporesponsive to COVID-19 vaccination. (Source: Hepatology International)
Source: Hepatology International - April 9, 2022 Category: Infectious Diseases Source Type: research

A rare genetic variant in the manganese transporter SLC30A10 and elevated liver enzymes in the general population
ConclusionsSLC30A10 p.Thr95Ile was associated with elevated liver enzymes in two large general population cohorts, and with MRI-quantified hepatic inflammation.Graphical abstractA rare genetic variant (p.Thr95Ile) in the manganese transporterSLC30A10 is associated with elevated plasma alanine transaminase (ALT) and higher corrected T1 on liver MRI, markers of liver inflammation. These data support that the variant may increase the risk of liver disease. (Source: Hepatology International)
Source: Hepatology International - April 9, 2022 Category: Infectious Diseases Source Type: research

The best predictive model for post-SVR HCC: can it be universal?
(Source: Hepatology International)
Source: Hepatology International - April 8, 2022 Category: Infectious Diseases Source Type: research