Impact of propofol sedation on the diagnostic accuracy of hepatic venous pressure gradient measurements in patients with cirrhosis
AbstractBackgroundMeasurement of the hepatic venous pressure gradient (HVPG) is the gold standard to evaluate the presence and severity of portal hypertension. The procedure is generally safe and well tolerated, but nevertheless, some patients demand for sedation. However, it is unknown whether propofol sedation would impair the accuracy of portal pressure measurements.MethodsThis is a prospective observational cohort study including cirrhotic patients with suspected portal hypertension undergoing invasive measurement of HVPG. Measurements of HVPG were performed in awake condition as well as under sedation with propofol in...
Source: Hepatology International - October 26, 2021 Category: Infectious Diseases Source Type: research

Hepatic tuberculosis masquerading as malignancy
ConclusionHTB is rare and can mimic a malignancy clinico-radiologically. Calcifications and pseudocapsule appearance on multiphase CT scan may help in differentiating HTB from hepatic malignancy. Tumor markers are normal while histopathology is generally diagnostic. A high index of suspicion is required to avoid unnecessary surgery as the patients respond well to ATT.Trial registrationThis is a  retrospective and observational study hence clinical trial registration is not applicable. (Source: Hepatology International)
Source: Hepatology International - October 23, 2021 Category: Infectious Diseases Source Type: research

Metabolic-associated fatty liver disease and major adverse cardiac events in patients with chronic coronary syndrome: a matched case –control study
This study included 3306 patients with CCS who were diagnosed with MAFLD. Controls without MAFLD were matched (1:1) to cases by age and gender. All participants were followed up for the occurrence of MACEs. Finally, the association between MAFLD and the risk of MACEs was assessed.ResultsDuring an average of 55.09  ± 19.92 months follow-up, 376 and 248 MACEs were observed in MAFLD and control groups, respectively. When compared with controls, Kaplan–Meier analysis showed that patients with MAFLD had significantly lower event-free survival rate and multivariate Cox regression analysis further ...
Source: Hepatology International - October 9, 2021 Category: Infectious Diseases Source Type: research

Are herbals more hepatotoxic than prescription medications?
(Source: Hepatology International)
Source: Hepatology International - October 5, 2021 Category: Infectious Diseases Source Type: research

Hepatic fibrosis is associated with an increased rate of decline in bone mineral density in men with nonalcoholic fatty liver disease
ConclusionsNAFLD was not associated with the total hip BMD decline rate. However, hepatic fibrosis was significantly associated with an increased rate of decline in total hip BMD in men with NAFLD.Clinical trial registrationThis study is a retrospective observational study and is not a drug trial. There was no need for clinical trial registration. (Source: Hepatology International)
Source: Hepatology International - October 4, 2021 Category: Infectious Diseases Source Type: research

‘First week’ is the crucial period for deciding living donor liver transplantation in patients with acute-on-chronic liver failure
AbstractBackground and aimsAcute-on-chronic liver failure (ACLF) is a rapidly progressive illness with high short-term mortality. Timely liver transplant (LT) may improve survival. We evaluated various indices for assessment of the severity of liver failure and their application for eligibility and timing of living donor LT (LDLT).MethodsAltogether 1021 patients were analyzed for the severity and organ failure at admission to determine transplant eligibility and 28  day survival with or without transplant.ResultsThe ACLF cohort [mean age 44  ± 12.2 years, males 81%) was of sick patients; 55% ...
Source: Hepatology International - October 4, 2021 Category: Infectious Diseases Source Type: research

Connection between HPS and ACLF: a solution of chaos?
(Source: Hepatology International)
Source: Hepatology International - October 4, 2021 Category: Infectious Diseases Source Type: research

Effect of microbiota metabolites on the progression of chronic hepatitis B virus infection
AbstractAccumulating evidence shows that the intestinal microbiota is closely related to the pathophysiology and the disease progression of chronic hepatitis B virus (HBV) infection. The intestinal microbiota acts on the host through its metabolites. This review aimed to discuss the effects of gut microbiota metabolites on the disease progression of chronic HBV infection. A literature search on PubMed database and Wiley Online Library with pre-specified criteria yielded 96 unique results. After consensus by all authors, the contents from 86 original publications were extracted and included in this review. In liver disease ...
Source: Hepatology International - October 1, 2021 Category: Infectious Diseases Source Type: research

Application of CRISPR-Cas9 based gene editing to study the pathogenesis of colon and liver cancer using organoids
AbstractTwo breakthrough techniques that have totally revolutionized biology in last 1 decade are the discovery of genome editing tools and growing the stem cells/primary tissue explants in defined 3D culture. In this regard the discovery of CRISPR-Cas9 as a specific gene editing tool and organoid culture from adult stem cell has provided easy handy tools to uncover the process of organ development and also modeling cancer. Genetically modified organoids have been developed by sequential knockout and knockin of driver mutations by genome editing followed by niche-based selection. The modified organoids when xenotransplante...
Source: Hepatology International - October 1, 2021 Category: Infectious Diseases Source Type: research

Correction to: Combined viral quasispecies diversity and hepatitis B core-related antigen predict off-nucleos(t)ide analog durability in HBeAg-negative patients
(Source: Hepatology International)
Source: Hepatology International - September 25, 2021 Category: Infectious Diseases Source Type: research

Non-alcoholic fatty liver disease frequency and associated factors at admission of acute stroke
ConclusionsThe frequency of NAFLD was high in our patient group. Significant NAFLD-presence factors were high BMI, low AST/ALT ratio, high serum albumin level, high PA%, and high DGLA level. A further study is warranted to determine the effects of the NAFLD-presence factors on stroke onset or prevention. (Source: Hepatology International)
Source: Hepatology International - September 15, 2021 Category: Infectious Diseases Source Type: research

Long-term morbidity and mortality in 2-year hepatoblastoma survivors treated with SIOPEL risk-adapted strategies
ConclusionsWith current risk-adapted strategies, hepatoblastoma is a highly curable disease, with very rare relapses, and few late effects except hearing loss which remains a serious condition in these very young patients. (Source: Hepatology International)
Source: Hepatology International - September 10, 2021 Category: Infectious Diseases Source Type: research

A systematic review and meta-analysis of anticoagulation therapy for portal vein thrombosis in patients with cirrhosis: to treat or not to treat?
ConclusionsIn cirrhotic patients with PVT, anticoagulation therapy helps increase rate of PVT recanalization and improve survival, but may also carry higher risks of bleeding compared to no treatment. Our findings support the use of anticoagulation in cirrhotic patients with PVT. (Source: Hepatology International)
Source: Hepatology International - September 6, 2021 Category: Infectious Diseases Source Type: research

Sex and regional disparities in incidence of hepatocellular carcinoma in autoimmune hepatitis: a systematic review and meta-analysis
ConclusionA higher HCC incidence in AIH was observed among male and in Asian populations. Cirrhosis status at AIH diagnosis is significantly associated with an increased incidence rate for HCC, and routine HCC surveillance is recommended for patients with AIH cirrhosis, especially for those in Asia. (Source: Hepatology International)
Source: Hepatology International - September 3, 2021 Category: Infectious Diseases Source Type: research

A prognostic model for hepatocellular carcinoma patients based on signature ferroptosis-related genes
ConclusionThe nomogram based on ferroptosis-related genes showed good performance for predicting the prognosis of HCC patients. The model may provide a reference for the evaluation of HCC patients by targeting ferroptosis. (Source: Hepatology International)
Source: Hepatology International - August 27, 2021 Category: Infectious Diseases Source Type: research

Establishment of a murine model of acute-on-chronic liver failure with multi-organ dysfunction
AbstractBackground and aimsAcute-on-chronic liver failure (ACLF) is a distinct clinical entity with high probability of organ failure and mortality. Since patients generally present late, experimental models are needed to understand the pathophysiology and natural course of the disease.MethodologyTo reproduce the syndrome of ACLF, chronic liver disease was induced in C57BL6 mice (6 –8 weeks; approximately 20–24 g weight) by intraperitoneal administration of carbon tetrachloride (CCl4) for 10  weeks followed by an acute injury with acetaminophen (APAP) and lipopolysaccharide (LPS). Blood, ascitic ...
Source: Hepatology International - August 25, 2021 Category: Infectious Diseases Source Type: research

APASL clinical practice guideline on hepatitis B reactivation related to the use of immunosuppressive therapy
AbstractBackground& AimHepatitis B reactivation related to the use of immunosuppressive therapy remains a major cause of liver-related morbidity and mortality in hepatitis B endemic Asia-Pacific region. This clinical practice guidelines aim to assist clinicians in all disciplines involved in the use of immunosuppressive therapy to effectively prevent and manage hepatitis B reactivation.MethodsAll publications related to hepatitis B reactivation with the use of immunosuppressive therapy since 1975 were reviewed. Advice from key opinion leaders in member countries/administrative regions of Asian-Pacific Association for t...
Source: Hepatology International - August 24, 2021 Category: Infectious Diseases Source Type: research

Volumetric assessment and clinical predictors of cirrhosis in patients undergoing hepatectomy for hepatocellular carcinoma with presumed normal liver function
AbstractAimIndocyanine green retention rate at 15  min (ICGR15) is a frequently used indicator of liver function. Herein, clinicopathological characteristics of cirrhotic patients with normal ICGR15 value (
Source: Hepatology International - August 23, 2021 Category: Infectious Diseases Source Type: research

A network meta-analysis of direct oral anticoagulants for portal vein thrombosis in cirrhosis
ConclusionThe network analysis supports the use of DOACs in cirrhotic patients, with significant rates of complete recanalization compared to other treatments without increasing bleeding risk. DOACs can potentially be considered for nontumorous PVT in cirrhosis. (Source: Hepatology International)
Source: Hepatology International - August 21, 2021 Category: Infectious Diseases Source Type: research

Efficacy of apatinib in patients with sorafenib –transarterial chemoembolization refractory hepatocellular carcinoma: a retrospective study
AbstractPurposeTo investigate the efficacy of sequential apatinib treatment in patients with unresectable hepatocellular carcinoma (HCC) refractory to sorafenib –transarterial chemoembolization (TACE).Materials and methodsThis respective study was conducted on 95 consecutive patients with sorafenib –TACE-refractory unresectable HCC in our center from January 2014 to December 2019. According to the response to sorafenib–TACE treatment and the subsequent management, the eligible patients were assigned into three groups: sorafenib–TACE (ST) group, sorafenib–TACE–apatinib (STA) group, an d s...
Source: Hepatology International - August 20, 2021 Category: Infectious Diseases Source Type: research

Impact of tenofovir alafenamide vs. entecavir on hepatocellular carcinoma risk in patients with chronic hepatitis B
ConclusionsThese findings suggest that ETV- and TAF-treated CHB patients have similar risk of developing HCC. Further studies with the larger sample size and longer follow-up are needed to validate these results. (Source: Hepatology International)
Source: Hepatology International - August 16, 2021 Category: Infectious Diseases Source Type: research

First-in-Asian double-blind randomized trial to assess the efficacy and safety of insulin sensitizer in nonalcoholic steatohepatitis patients
AbstractBackgroundThe efficacy and safety of insulin sensitizer in Asians with non-alcoholic steatohepatitis (NASH) remain elusive.AimsThe double-blind, randomized, placebo-controlled trial was conducted aiming to investigate the efficacy and safety of pioglitazone in NASH patients.MethodsA total of 90 NASH patients (66 males, age  = 44.1 ± 12.7 years) were prospectively randomized into oral pioglitazone 30 mg/day (Arm A) or placebo (Arm B) for 24 weeks. The primary endpoint was the efficacy of pioglitazone in reducing inflammation and liver fat at end-of-treatment (EOT). N...
Source: Hepatology International - August 12, 2021 Category: Infectious Diseases Source Type: research

Herbal and dietary supplement-induced liver injury in Taiwan: comparison with conventional drug-induced liver injury
ConclusionsHDS are popular and incriminated in more than one-fifth of drug-induced liver injuries in Taiwan. The patients with HILI were more severe than those with CILI in terms of liver biochemical tests, complications and mortality. Hepatitis B carriers, those with elevated baseline liver tests and crude herb users may have a higher risk of HILI-related mortality. The prudent use of HDS is suggested in these high-risk subjects. (Source: Hepatology International)
Source: Hepatology International - August 11, 2021 Category: Infectious Diseases Source Type: research

Diabetes is associated with poor short-term prognosis in patients with hepatitis B virus-related acute-on-chronic liver failure
ConclusionImpaired pancreatic β-cell function is related to diabetes development, and diabetes is associated with high mortality in patients with chronic HBV-related ACLF. (Source: Hepatology International)
Source: Hepatology International - August 10, 2021 Category: Infectious Diseases Source Type: research

Primary prophylaxis of gastric variceal bleeding: the choices need to be tested!!
(Source: Hepatology International)
Source: Hepatology International - August 10, 2021 Category: Infectious Diseases Source Type: research

Clinical course of liver injury induced by immune checkpoint inhibitors in patients with advanced malignancies
ConclusionThe incidence pattern and therapeutic response to corticosteroids in immune-related liver injury differ according to the injury type. Although corticosteroids were effective for the hepatocellular pattern, an additional strategy for refractory non-hepatocellular patterns is needed. (Source: Hepatology International)
Source: Hepatology International - August 9, 2021 Category: Infectious Diseases Source Type: research

Long-term outcome of liver complications in patients with chronic HBV/HCV co-infection after antiviral therapy: a real-world nationwide study on Taiwanese Chronic Hepatitis C Cohort (T-COACH)
AbstractBackground and aimThe long-term outcome of hepatitis B virus (HBV) infection among patients dually infected with HBV and hepatitis C virus (HCV) remains unclear. We aimed to investigate the long-term liver outcomes of HBV/HCV-coinfected patients after antiviral therapy.MethodsA total of 11,359 chronically HCV-infected patients with interferon-based therapy were registered in a nationwide Taiwanese Chronic Hepatitis C Cohort. A propensity score matched (PSM) cohort of HCV mono-infected (n = 7020) and HBV/HCV (n = 702) co-infected patients by age, sex, and fibrosis was recruited for outcom...
Source: Hepatology International - August 7, 2021 Category: Infectious Diseases Source Type: research

Increased risk of cancer in patients with primary sclerosing cholangitis
ConclusionsPSC patients have a four times overall increased risk of developing cancer compared to the general population, with increased risk of developing hepatobiliary, colorectal, and pancreatic cancer, as well as lymphoma. (Source: Hepatology International)
Source: Hepatology International - August 6, 2021 Category: Infectious Diseases Source Type: research

The global trends and regional differences in incidence and mortality of hepatitis A from 1990 to 2019 and implications for its prevention
AbstractBackground and purposeDespite decades of improved sanitation and hygiene measures and vaccine introduction, hepatitis A has been spread through numerous outbreaks globally. We used data from the Global Burden of Disease (GBD) study to quantify hepatitis A burden at the global, regional and national levels.MethodsAnnual incident cases, deaths, age-standardized incidence rates (ASIRs), and age-standardized mortality rates (ASMRs) of hepatitis A between 1990 and 2019 were derived from the GBD study 2019. Percentage changes of cases and deaths, and estimated annual percentage changes (EAPCs) of ASIRs and ASMRs were cal...
Source: Hepatology International - August 3, 2021 Category: Infectious Diseases Source Type: research

Iodized oil computed tomography versus ultrasound-guided radiofrequency ablation for early hepatocellular carcinoma
ConclusionIoCT-guided RFA had a lower local tumor progression rate and better recurrence-free survival than did US-guided RFA for HCC within the Milan criteria.Graphic abstractCT-guide RFA is a safe and effective alternative to US-guided with similar overall survival.IoCT-guided RFA might have a better local tumor control than US-guided.IoCT-guided RFA may be more suitable for male patients, aged  
Source: Hepatology International - August 2, 2021 Category: Infectious Diseases Source Type: research

Targeted inhibition of FGF19/FGFR cascade improves antitumor immunity and response rate in hepatocellular carcinoma
ConclusionsOur findings suggest that HCC patients with high FGFR2/3 or FGF19/FGFR4 expressing tumors might benefit from a combination infigratinib/FGF401; thus, supporting its evaluation in clinical trials. (Source: Hepatology International)
Source: Hepatology International - July 31, 2021 Category: Infectious Diseases Source Type: research

Hepatopulmonary syndrome is related to the development of acute-on-chronic liver failure and poor prognosis in cirrhotic patients
AbstractBackground and aimsLong-term prospective data on hepatopulmonary syndrome (HPS) from a large number of patients, especially in Asian patients, are lacking. We evaluated the long-term prognosis of HPS and the development of acute-on-chronic liver failure (ACLF), and related factors.MethodsA total of 142 patients with cirrhosis who underwent saline-agitated contrast echocardiography for the diagnosis of HPS were enrolled and observed prospectively from 2014 to 2019.ResultsA total of 59 patients (41%) were diagnosed with HPS (24 grade 1, 23 grade 2, 12 grade 3). Thirty-eight and 37 patients died in the HPS and non-HPS...
Source: Hepatology International - July 28, 2021 Category: Infectious Diseases Source Type: research

Alterations of gut microbiome and metabolite profiles in choledocholithiasis concurrent with cholangitis
AbstractBackground and aimsGut microbiota and their metabolic products might play important roles in regulating the pathogenesis of choledocholithiasis concurrent with cholangitis (CC). The aim of this study was to explore the characteristic gut dysbiosis, metabolite profiles and the possible roles in patients with CC.MethodsA case –control study was carried out to analyze the alterations in the intestinal microbiota and their metabolites in patients with CC (n = 25) compared with healthy controls (HCs) (n = 25) by metagenomic sequencing to define the gut microbiota community and liquid ch...
Source: Hepatology International - July 27, 2021 Category: Infectious Diseases Source Type: research

Efficacy and safety of tenofovir disoproxil fumarate and tenofovir alafenamide fumarate in preventing HBV vertical transmission of high maternal viral load
AbstractBackgroundHepatitis B virus (HBV) infection is a significant global health problem and  >  42–52% of patients are infected during perinatal period. Tenofovir alafenamide fumarate (TAF) and tenofovir disoproxil fumarate (TDF) have been widely recognized as the main compounds used for antiviral treatment of hepatitis B. The present study evaluated the efficacy and safety of TAF in redu cing HBV vertical transmission.MethodsA total of 72 pregnant women, who met the inclusion criteria, were randomly divided into the TDF (300  mg/day,n = 36) and TAF (25 mg/day,n =&th...
Source: Hepatology International - July 26, 2021 Category: Infectious Diseases Source Type: research

APASL guidance on stopping nucleos(t)ide analogues in chronic hepatitis B patients
AbstractChronic hepatitis B virus (HBV) infection is currently incurable. Long-term treatment with potent and safe nucleos(t)ide analogs (NAs) can reduce hepatocellular carcinoma (HCC) and cirrhosis-related complications through profound viral suppression. However, indefinite therapy raises several crucial issues with pros and cons. Because seroclearance of hepatitis B surface (HBsAg) as functional cure is not easily achievable, a finite therapy including sequential 48-week pegylated interferon therapy may provide an opportunity to facilitate HBsAg seroclearance by the rejuvenation of exhausted immune cells. However, the c...
Source: Hepatology International - July 23, 2021 Category: Infectious Diseases Source Type: research

Portal vein thrombosis associated with high 14-day and 6-week rebleeding in patients after oesophageal variceal band ligation: a retrospective, multicentre, nested case –control study
AbstractBackground and aimsThe association between prognosis of variceal bleeding and portal vein thrombosis (PVT) is unclear. In this multicentre study, we determined the effect of PVT on rebleeding and mortality in patients with acute variceal bleeding (AVB) after oesophageal variceal band ligation (EVL).MethodsCirrhotic patients with AVB who had undergone EVL were included. The patients were allocated to either the PVT group or the control cirrhotic group (CCG) based on the presence or absence of PVT. One-year rebleeding episodes and mortality after EVL were recorded.ResultsA total of 218 cirrhotic patients with AVB fro...
Source: Hepatology International - July 22, 2021 Category: Infectious Diseases Source Type: research

Dynamic assessments of hepatic encephalopathy and ammonia levels predict mortality in acute-on-chronic liver failure
AbstractBackgroundWe evaluated the dynamics of hepatic encephalopathy (HE) and ammonia estimation in acute-on-chronic liver failure (ACLF) patients due to a paucity of evidence.MethodsACLF patients recruited from the APASL-ACLF Research Consortium (AARC) were followed up till 30  days, death or transplantation, whichever earlier. Clinical details, including dynamic grades of HE and laboratory data, including ammonia levels, were serially noted.ResultsOf the 3009 ACLF patients, 1315 (43.7%) had HE at presentation; grades I –II in 981 (74.6%) and grades III–IV in 334 (25.4%) patients. The independent predict...
Source: Hepatology International - July 18, 2021 Category: Infectious Diseases Source Type: research

Evidence of nucleos(t)ide analogue (NUC) therapy in HBV DNA negative decompensated cirrhosis
(Source: Hepatology International)
Source: Hepatology International - July 16, 2021 Category: Infectious Diseases Source Type: research

Longitudinal progression of clinical variables associated with graded liver injury in COVID-19 patients
This study investigated the temporal progression of clinical variables of in-hospital liver injury in COVID-19 patients.MethodsCOVID-19 patients (n = 1361) were divided into no, mild and severe liver injury (nLI, mLI and sLI) groups. Time courses of laboratory variables were time-locked to liver-injury onset defined by alanine aminotransferase level. Predictors of liver injury were identified using logistic regression.ResultsThe prevalence of mLI was 39.4% and sLI was 9.2%. Patients with escalated care had higher prevalence of sLI (23.2% vs. 5.0%,p 
Source: Hepatology International - July 15, 2021 Category: Infectious Diseases Source Type: research

The overview of the deep learning integrated into the medical imaging of liver: a review
AbstractDeep learning (DL) is a recently developed artificial intelligent method that can be integrated into numerous fields. For the imaging diagnosis of liver disease, several remarkable outcomes have been achieved with the application of DL currently. This advanced algorithm takes part in various sections of imaging processing such as liver segmentation, lesion delineation, disease classification, process optimization, etc. The DL optimized imaging diagnosis shows a broad prospect instead of the pathological biopsy for the advantages of convenience, safety, and inexpensiveness. In this paper, we reviewed the published r...
Source: Hepatology International - July 15, 2021 Category: Infectious Diseases Source Type: research

Controlled attenuation parameter value and the risk of hepatocellular carcinoma in chronic hepatitis B patients under antiviral therapy
AbstractBackgroundControlled attenuation parameter (CAP) can evaluate hepatic steatosis in patients with chronic hepatitis B (CHB). However, prognostic implications of CAP value remain unclear. We evaluated the association between CAP and the risk of hepatocellular carcinoma (HCC) in patients with CHB under antiviral therapy and maintained virologic response.MethodsA total of 1823 CHB patients who were taking nucleos(t)ide analogue and showing suppressed hepatitis B virus replication were analyzed. The primary outcome was incident HCC during follow-up. Patients were grouped into those with and without advanced chronic live...
Source: Hepatology International - July 14, 2021 Category: Infectious Diseases Source Type: research

Survival analysis between laparoscopic and open hepatectomy for hepatocellular carcinoma: a meta-analysis based on reconstructed time-to-event data
AbstractBackground/purpose of the studyLaparoscopic hepatectomy (LH) has been widely used in the treatment of hepatocellular carcinoma (HCC). It is generally believed that the long-term outcomes of LH are not inferior to open hepatectomy (OH). However, the quality of evidence is low. The purpose of this study was to reconstruct time-to-event data for meta-analysis based on Kaplan –Meier curves from propensity-score matched studies and compare survival rates following LH and OH for hepatocellular carcinoma.MethodsAll published propensity-score matched studies reported in English that compared LH and OH for hepatocellu...
Source: Hepatology International - July 13, 2021 Category: Infectious Diseases Source Type: research

Assessment of liver fibrosis by transient elastography in young children with chronic hepatitis B  virus infection
This study aimed to compare the diagnostic accuracy of transient elastography (TE) and biopsy for the detection of liver fibrosis in children with chronic hepatitis B (CHB).MethodsThis single-center prospective study included 157 CHB children aged 0 –6 years. All patients underwent liver stiffness measurement (LSM) by TE and liver biopsy, separated by an interval of less than 1 week.ResultsThe LSM, aspartate aminotransferase-platelet ratio index (APRI), and fibrosis-4 index (FIB-4) were positively correlated with activity grade and fibrosis stage in CHB children. The areas under the receiver operating chara...
Source: Hepatology International - July 9, 2021 Category: Infectious Diseases Source Type: research

Budd-Chiari syndrome: consensus guidance of the Asian Pacific Association for the study of the liver (APASL)
AbstractBudd Chiari syndrome (BCS) is a diverse disease with regard to the site of obstruction, the predisposing thrombophilic disorders and clinical presentation across the Asia-Pacific region. The hepatic vein ostial stenosis and short segment thrombosis are common in some parts of Asia-Pacific region, while membranous obstruction of the vena cava is common in some and complete thrombosis of hepatic veins in others. Prevalence of myeloproliferative neoplasms and other thrombophilic disorders in BCS varies from region to region and with different sites of obstruction. This heterogeneity also raises several issues and dile...
Source: Hepatology International - July 8, 2021 Category: Infectious Diseases Source Type: research

Hepatocyte-derived exosome may be as a biomarker of liver regeneration and prognostic valuation in patients with acute-on-chronic liver failure
ConclusionThe exosomes profile with ALB and VEGF may be a more accurate and specific biomarker of liver regeneration and prognostic valuation than AFP in patients with ACLF. In addition, the exosomes profile with CD63 and ALB may be an early-warning marker in patients with ACLF. (Source: Hepatology International)
Source: Hepatology International - July 7, 2021 Category: Infectious Diseases Source Type: research

A step forward in the choice of fluid for early resuscitation of critically ill patients with cirrhosis
(Source: Hepatology International)
Source: Hepatology International - July 7, 2021 Category: Infectious Diseases Source Type: research

Abstract
(Source: Hepatology International)
Source: Hepatology International - July 2, 2021 Category: Infectious Diseases Source Type: research

Comparative accuracy of prognostic models for short-term mortality in acute-on-chronic liver failure patients: CAP-ACLF
ConclusionsAPASL-ACLF is often a progressive disease, and models assessed up to day 7 of presentation reliably predict 30-day mortality. Day-7 AARC model is a statistically robust tool for classifying risk of death and accurately predicting 30-day outcomes with relatively lower prediction errors. Day-7 AARC score>  12 may be used as a futility criterion in APASL-ACLF patients. (Source: Hepatology International)
Source: Hepatology International - June 25, 2021 Category: Infectious Diseases Source Type: research

Reduced hepatic steatosis is associated with higher risk of hepatocellular carcinoma in chronic hepatitis B infection
AbstractBackgroundConcomitant chronic hepatitis B infection (CHB) and non-alcoholic fatty liver disease (NAFLD) is common, but the implications of NAFLD on clinical outcomes of CHB, including hepatocellular carcinoma (HCC), are not well-investigated.MethodsCHB patients were recruited for transient elastography assessment for liver stiffness (LS), and controlled attenuation parameter (CAP), a non-invasive quantification of hepatic steatosis, and were prospectively followed up for development of HCC. Steatosis and severe steatosis were diagnosed by CAP  ≥ 248 dB/m and ≥ 280 dB/m re...
Source: Hepatology International - June 21, 2021 Category: Infectious Diseases Source Type: research

The clinical and economic burden of non-alcoholic steatohepatitis in the Middle East: behind the scene
(Source: Hepatology International)
Source: Hepatology International - June 18, 2021 Category: Infectious Diseases Source Type: research