Fecal microbiota transplantation in alcoholic hepatitis: new treatment paradigm or a shot in the dark?
(Source: Hepatology International)
Source: Hepatology International - April 24, 2023 Category: Infectious Diseases Source Type: research
Furthering research on MAFLD: the APASL Metabolic fAtty lIver DiseasE coNsortium (MAIDEN)
(Source: Hepatology International)
Source: Hepatology International - April 20, 2023 Category: Infectious Diseases Source Type: research
Impact of metabolic factors on risk of cardiovascular disease in nondiabetic metabolic dysfunction-associated fatty liver disease
ConclusionDiabetic MAFLD predicted high-risk CVD phenotypes the best. Metabolic risk abnormalities in nondiabetic MAFLD patients were independently associated with the risk of CVD. The proposed diagnostic criteria for nondiabetic MAFLD need further investigation in terms of CVD risk. (Source: Hepatology International)
Source: Hepatology International - April 17, 2023 Category: Infectious Diseases Source Type: research
Messenger RNA electroporated hepatitis B virus (HBV) antigen-specific T cell receptor (TCR) redirected T cell therapy is well-tolerated in patients with recurrent HBV-related hepatocellular carcinoma post-liver transplantation: results from a phase I trial
ConclusionThis study has demonstrated that multiple infusions of mRNA electroporated HBV-specific TCR T cells were well-tolerated in patients with HBV-positive recurrent HCC post-liver transplant. (Source: Hepatology International)
Source: Hepatology International - April 17, 2023 Category: Infectious Diseases Source Type: research
MAFLD and chronic kidney disease: two sides of the same coin?
(Source: Hepatology International)
Source: Hepatology International - April 17, 2023 Category: Infectious Diseases Source Type: research
OHCCPredictor: an online risk stratification model for predicting survival duration of older patients with hepatocellular carcinoma
ConclusionsAge, sex, marital status, T stage, N stage, surgery, chemotherapy, tumor size, AFP level, fibrosis score, bone metastasis, lung metastasis, and grade were independent prognostic factors for elderly patients with HCC. The constructed nomogram model based on the above factors could accurately predict the prognosis of such patients. Besides, the developed online web interface of the predictive model provide easily obtained access for clinicians. (Source: Hepatology International)
Source: Hepatology International - April 17, 2023 Category: Infectious Diseases Source Type: research
Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the Liver
(Source: Hepatology International)
Source: Hepatology International - April 17, 2023 Category: Infectious Diseases Source Type: research
Laparoscopic and open liver resection for hepatocellular carcinoma with type 2 diabetes mellitus: multicenter propensity score-matched study
ConclusionsLaparoscopic liver resection for HCC patients with T2DM can be safely performed with favorable perioperative and long-term oncological outcomes at high-volume liver cancer centers, regardless of the course of T2DM. (Source: Hepatology International)
Source: Hepatology International - April 15, 2023 Category: Infectious Diseases Source Type: research
Hyperdynamic circulation in cirrhosis: a novel gutsy central neuronal mechanism
(Source: Hepatology International)
Source: Hepatology International - April 15, 2023 Category: Infectious Diseases Source Type: research
Liver-derived extracellular vesicles from patients with hepatitis B virus-related acute-on-chronic liver failure impair hepatic regeneration by inhibiting on FGFR2 signaling via miR-218-5p
ConclusionThe current data reveal the mechanism underlying impaired liver regeneration in HBV-ACLF that promotes the discovery of new therapeutic approaches.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - April 13, 2023 Category: Infectious Diseases Source Type: research
Therapeutic role of FNDC5/irisin in attenuating liver fibrosis via inhibiting release of hepatic stellate cell-derived exosomes
ConclusionAll these results demonstrate that FNDC5/irisin is a novel therapeutic agent for chronic liver fibrosis. (Source: Hepatology International)
Source: Hepatology International - April 12, 2023 Category: Infectious Diseases Source Type: research
Efficacy and safety of lenvatinib plus PD-1 inhibitor with or without transarterial chemoembolization in unresectable hepatocellular carcinoma
ConclusionTriple therapy of lenvatinib, PD-1 inhibitor, and TACE may achieve more favorable survival benefits than dual therapy of lenvatinib and PD-1 inhibitor in unresectable HCC patients with manageable safety profiles. (Source: Hepatology International)
Source: Hepatology International - April 10, 2023 Category: Infectious Diseases Source Type: research
Development of a deep pathomics score for predicting hepatocellular carcinoma recurrence after liver transplantation
ConclusionsThis study established an effective DPS. Immune cells were the most significant histological structure related to HCC recurrence. DPS performed well in post-LT recurrence prediction and the identification of clinicopathological features. (Source: Hepatology International)
Source: Hepatology International - April 8, 2023 Category: Infectious Diseases Source Type: research
Endoscopic band ligation is safe despite low platelet count and high INR
ConclusionEBL is safe and procedure-related bleedings are rare (2.6%) including in patients with thrombocytopenia < 50 G/L or high INR ≥ 1.5. Only high MELD, and especially high bilirubin seem to be linked to an increased risk of EBL-related bleeding. (Source: Hepatology International)
Source: Hepatology International - April 6, 2023 Category: Infectious Diseases Source Type: research
Transcatheter arterial chemoembolization plus apatinib with or without camrelizumab for unresectable hepatocellular carcinoma: a multicenter retrospective cohort study
ConclusionsBoth TACE plus apatinib and TACE combined with apatinib plus camrelizumab were feasible in patients with unresectable HCC, with manageable safety profiles. Moreover, TACE combined with apatinib plus camrelizumab showed additional benefit. (Source: Hepatology International)
Source: Hepatology International - April 3, 2023 Category: Infectious Diseases Source Type: research
