Characteristics and long-term mortality of patients with non-MAFLD hepatic steatosis
ConclusionsNon-MAFLD steatosis has comparable degrees of hepatic steatosis and fibrosis to MAFLD and increases the risk of mortality. Genetic predisposition highly contributes to the risk of non-MAFLD steatosis. (Source: Hepatology International)
Source: Hepatology International - March 31, 2023 Category: Infectious Diseases Source Type: research
Characteristics of microbiome-derived metabolomics according to the progression of alcoholic liver disease
ConclusionsThis study identified that microbial metabolic dysbiosis is associated with ALD-related metabolic dysfunction. The SCFAs, bile acids, and indole compounds were depleted during ALD progression.Clinical trialClinicaltrials.gov, number NCT04339725. (Source: Hepatology International)
Source: Hepatology International - March 31, 2023 Category: Infectious Diseases Source Type: research
Abstracts
(Source: Hepatology International)
Source: Hepatology International - March 31, 2023 Category: Infectious Diseases Source Type: research
Another prognostic marker for hepatocellular carcinoma
(Source: Hepatology International)
Source: Hepatology International - March 31, 2023 Category: Infectious Diseases Source Type: research
Erectile dysfunction and cirrhosis: prevalence and a potential therapy
(Source: Hepatology International)
Source: Hepatology International - March 30, 2023 Category: Infectious Diseases Source Type: research
Metabolic interventions improve HBV envelope-specific T-cell responses in patients with chronic hepatitis B
ConclusionThese findings may provide valuable information for metabolically invigorating HBV-specific T-cells to treat CHB.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - March 28, 2023 Category: Infectious Diseases Source Type: research
Effectiveness and safety of 8-week glecaprevir/pibrentasvir in HCV treatment-na ïve patients with compensated cirrhosis: real-world experience from Taiwan nationwide HCV registry
ConclusionsIn this large-scale real-world Taiwanese cohort, 8-week GLE/PIB therapy was efficacious and well tolerated for treatment-na ïve compensated cirrhosis patients. SVR12 rates were similarly high as in the clinical trials, including those with characteristics of advanced liver disease. (Source: Hepatology International)
Source: Hepatology International - March 27, 2023 Category: Infectious Diseases Source Type: research
Evolution of risk prediction models for post-operative mortality in patients with cirrhosis
AbstractThe perception of high surgical risk among patients with cirrhosis has resulted in a long-standing reluctance to operate. Risk stratification tools, first implemented over 60 years ago, have attempted to assess mortality risk among cirrhotic patients and ensure the best possible outcomes for this difficult to treat cohort. Existing postoperative risk prediction tools including the Child –Turcotte–Pugh (CTP) and Model for End-stage Liver Disease (MELD) provide some prediction of risk in counselling patients and their families but tend to overestimate surgical risk. More personalised prediction algorithms such as...
Source: Hepatology International - March 27, 2023 Category: Infectious Diseases Source Type: research
Downregulated VISTA enhances Th17 differentiation and aggravates inflammation in patients with acute-on-chronic liver failure
ConclusionsThe decreased expression of VISTA may facilitate development of Th17 cells and promote the progression of inflammation in ACLF patients. These findings are helpful for elucidating the pathogenesis of ACLF and for the identification of new drug targets.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - March 22, 2023 Category: Infectious Diseases Source Type: research
Etiologic fractions in patients of hepatocellular carcinoma in India with and without a background of cirrhosis: a multi-centric study
ConclusionThis large multi-centric study demonstrates that NAFLD is the most important risk factor for development of both cirrhotic and non-cirrhotic HCC in India and has overtaken viral hepatitis. Awareness campaigns and large-scale screening are required to reduce the high burden of NAFLD-related HCC in India. (Source: Hepatology International)
Source: Hepatology International - March 20, 2023 Category: Infectious Diseases Source Type: research
Exosomal miR-200b-3p induce macrophage polarization by regulating transcriptional repressor ZEB1 in hepatocellular carcinoma
ConclusionThe study illustrates that HCC cell-derived miR-200b-3p exosomes facilitate the proliferation and polarization of macrophages by modulating cytokine secretion and the JAK/STAT signaling pathway, leading to the metastasis of HCC. These findings demonstrate the existence of a novel feedback loop between cancer cells and immune cells in the tumor microenvironment, presenting a new concept in cancer research. (Source: Hepatology International)
Source: Hepatology International - March 17, 2023 Category: Infectious Diseases Source Type: research
Bacterial translocation occurs early in cirrhosis and triggers a selective inflammatory response
ConclusionBT occurs already in early ACLD stages and triggers a systemic inflammatory response via TNF- α and IL-10. Interestingly, BT markers showed no clear correlation with portal hypertension and circulatory dysfunction in patients with stable ACLD.Clinical trial numberNCT03267615. (Source: Hepatology International)
Source: Hepatology International - March 7, 2023 Category: Infectious Diseases Source Type: research
Contribution of alcohol use to the global burden of cirrhosis and liver cancer from 1990 to 2019 and projections to 2044
ConclusionsAlthough the age-standardized rate of cirrhosis and liver cancer due to alcohol use have decreased, the absolute burden increased and will continue to increase. Therefore, alcohol control measures should be further strengthened and improved through effective national policies. (Source: Hepatology International)
Source: Hepatology International - March 5, 2023 Category: Infectious Diseases Source Type: research
Response to: “Is laparoscopic hepatectomy superior to laparotomic hepatectomy? The debate continues”
(Source: Hepatology International)
Source: Hepatology International - March 4, 2023 Category: Infectious Diseases Source Type: research
HBV, antivirals, and immunoglobulins after liver transplantation: all that glitters is not gold
(Source: Hepatology International)
Source: Hepatology International - March 2, 2023 Category: Infectious Diseases Source Type: research
