Etiology, outcome and prognostic indicators of acute liver failure in Asian children
ConclusionsOverall survival of PALF remained poor. High peak bilirubin and low GGT predict poor outcome of PALF. LIU score is a good model in predicting outcome of PALF and maybe useful in selecting children for emergency LT. (Source: Hepatology International)
Source: Hepatology International - September 21, 2022 Category: Infectious Diseases Source Type: research
Analysis of viral integration reveals new insights of oncogenic mechanism in HBV-infected intrahepatic cholangiocarcinoma and combined hepatocellular-cholangiocarcinoma
ConclusionComparative analysis demonstrates numerous newly discovered mutational events in ICC and CHC resulting from HBV insertions in the host genome. Our study provides an in-depth biological and clinical insights into HBV-induced ICC and CHC. (Source: Hepatology International)
Source: Hepatology International - September 20, 2022 Category: Infectious Diseases Source Type: research
Effects of antiviral therapy and drug withdrawal on postpartum hepatitis in pregnant women with chronic HBV infection
ConclusionWithdrawing antiviral drug immediately or at 6 weeks after delivery did not affect the incidence of postpartum hepatitis in CHB women, but delaying drug withdrawal might delay the onset of postpartum hepatitis.Clinical trial registration number: NCT03214302. (Source: Hepatology International)
Source: Hepatology International - September 15, 2022 Category: Infectious Diseases Source Type: research
Reduction of natural killer cells is associated with poor outcomes in patients with hepatitis B virus-related acute-on-chronic liver failure
ConclusionNK cells were significantly decreased and showed dysfunction of phenotypic and functional profiles across distinct subsets in the peripheral blood of patients with ACLF. Crosstalk between CXCL-10 and NK cells may mediate the unbalanced distribution of NK cells. Understanding the dysfunction and decrease in NK cells may provide new insights into ACLF pathogenesis. (Source: Hepatology International)
Source: Hepatology International - September 15, 2022 Category: Infectious Diseases Source Type: research
Influence of shunt occlusion on liver volume and functions in hyperammonemic cirrhosis patients having large porto-systemic shunts: a randomized control trial
ConclusionOcclusion of large SPSS results in improving the volume and synthetic functions of the liver by restoring hepato-petal portal flow besides reducing serum-ammonia level and recurrence of HE.ClinicalTrials.gov number, NCT03293459. (Source: Hepatology International)
Source: Hepatology International - September 12, 2022 Category: Infectious Diseases Source Type: research
The clinical implications of pre-liver transplant diabetes on post-liver transplant outcomes in patients with NASH: analysis of the UNOS database
ConclusionThe presence of pre-LT diabetes is associated with all-cause mortality and deaths due to cardiac and renal causes following LT. The findings warrant an early preoperative screening procedure to ensure that patients with diabetes have their metabolic risk factors optimized prior to LT. (Source: Hepatology International)
Source: Hepatology International - September 11, 2022 Category: Infectious Diseases Source Type: research
Systematic review and meta-analysis: impact of anti-viral therapy on portal hypertensive complications in HBV patients with advanced chronic liver disease
ConclusionNA therapy lowers the risk of portal hypertension-related complications, including variceal bleeding, HCC, and liver transplantation/death. (Source: Hepatology International)
Source: Hepatology International - September 9, 2022 Category: Infectious Diseases Source Type: research
Development and validation of a modified albumin –bilirubin grade and α-fetoprotein score (mALF score) for hepatocellular carcinoma patients receiving atezolizumab and bevacizumab
ConclusionThe mALF score can reliably predict the prognosis of HCC patients receiving Atez/Bev. (Source: Hepatology International)
Source: Hepatology International - September 9, 2022 Category: Infectious Diseases Source Type: research
Direct antiviral therapy for hepatitis C cirrhotic patients in liver transplantation settings: a systematic review
ConclusionDAA therapy for decompensated patients must be personalized with consideration of different factors, particularly among those with MELD scores between the two cutoff-values proposed by the current associational guidelines. (Source: Hepatology International)
Source: Hepatology International - September 9, 2022 Category: Infectious Diseases Source Type: research
Drug –drug interactions between direct-acting antivirals and co-medications: a territory-wide cohort study
ConclusionThe commonest co-medications leading to contraindication during DAA treatment were statins and antipsychotics. Category 2 and 3 DDIs are often managed by appropriate dose adjustments or temporary discontinuation of relevant co-medications. Careful assessment for potential DDI before DAA use is mandatory to avoid potential harmful effects.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - September 8, 2022 Category: Infectious Diseases Source Type: research
Long-term cardiovascular outcomes differ across metabolic dysfunction-associated fatty liver disease subtypes among middle-aged population
ConclusionLong-term cardiovascular disease outcomes differed across the MAFLD subtypes. Further studies are required to investigate whether preventive or therapeutic interventions should be optimized according to the MAFLD subtypes. (Source: Hepatology International)
Source: Hepatology International - September 7, 2022 Category: Infectious Diseases Source Type: research
Effectiveness of entecavir vs tenofovir disoproxil fumarate for functional cure of chronic hepatitis B in an international cohort
ConclusionsETV and TDF did not differ significantly in the incidence of HBsAg seroclearance, which rarely occurred with either regimen. (Source: Hepatology International)
Source: Hepatology International - September 7, 2022 Category: Infectious Diseases Source Type: research
The association between visceral adipocyte hypertrophy and NAFLD in subjects with different degrees of adiposity
ConclusionFor the first time, we reported that visceral adipocyte hypertrophy was associated with the onset and progression of NAFLD in mild to moderate adiposity but not in severe obesity, which may be mediated by adipose tissue insulin resistance. (Source: Hepatology International)
Source: Hepatology International - September 7, 2022 Category: Infectious Diseases Source Type: research
MAFLD, patient-centred care, and APASL
AbstractAsian –Pacific nations are home to more than half the world’s population and similar to other global super regions, metabolic dysfunction associated fatty liver disease (MAFLD) is the principal cause for chronic liver disease. To address the challenges ahead for tackling the disease at-scale, the Asia n Pacific Association for the Study of the Liver (APASL) was the first pan-national society to endorse and lead the process for redefining the disease and adopting the more appropriate term “MAFLD” with its accompanying set of positive diagnostic criteria. As with this initiative, APASL and Hepa tology Interna...
Source: Hepatology International - September 7, 2022 Category: Infectious Diseases Source Type: research
Development and experimental verification of a prognosis model for cuproptosis-related subtypes in HCC
ConclusionOur findings indicate the involvement of CRG regulation in HCC and provide new insights into prognosis assessment. Drug sensitivity analysis predicted drug candidates for the treatment of patients with different HCC subtypes.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - September 5, 2022 Category: Infectious Diseases Source Type: research
