The effectiveness of combination therapy with interferon and nucleoside analogs in pediatric patients with chronic hepatitis B: a systematic review and meta-analysis
ConclusionsCombination therapy with IFN and NAs is more effective than IFN monotherapy in viral suppression and serological response for children with CHB. More studies were still needed to reveal the efficacy of this combination therapy compared with NAs monotherapy. (Source: Hepatology International)
Source: Hepatology International - December 5, 2022 Category: Infectious Diseases Source Type: research
Obituary
(Source: Hepatology International)
Source: Hepatology International - November 25, 2022 Category: Infectious Diseases Source Type: research
The clinical implications and molecular features of intrahepatic cholangiocarcinoma with perineural invasion
ConclusionOur study deciphered the genomic features and the immune suppressive metastasis-prone niche in ICC with PNI. Patients with PNI showed a poor prognosis after surgery but a good response to adjuvant chemotherapy.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - November 22, 2022 Category: Infectious Diseases Source Type: research
Correction to: Development and validation of a modified albumin –bilirubin grade and α-fetoprotein score (mALF score) for hepatocellular carcinoma patients receiving atezolizumab and bevacizumab
(Source: Hepatology International)
Source: Hepatology International - November 16, 2022 Category: Infectious Diseases Source Type: research
Good outcomes of living donor liver transplant in primary sclerosing cholangitis: an experience from North India
ConclusionLDLT can be performed in PSC with good long-term outcomes with a risk of PSC recurrence in about one-fifth patients. (Source: Hepatology International)
Source: Hepatology International - November 14, 2022 Category: Infectious Diseases Source Type: research
Fully connected neural network-based serum surface-enhanced Raman spectroscopy accurately identifies non-alcoholic steatohepatitis
ConclusionsFully connected neural network-based serum SERS analysis is a rapid and practical tool for the non-invasive identification of NASH. The online calculator website for the estimated risk of NASH is freely available to healthcare providers and researchers (http://www.pan-chess.cn/calculator/RAMAN_score). (Source: Hepatology International)
Source: Hepatology International - November 11, 2022 Category: Infectious Diseases Source Type: research
Diet-derived antioxidants and nonalcoholic fatty liver disease: a Mendelian randomization study
ConclusionOverall, we observed the positive associations of genetically predicted selenium and lycopene with NAFLD. However, the genetically predicted β-carotene and retinol levels were inversely associated with the risk of T2D.Graphical Abstract (Source: Hepatology International)
Source: Hepatology International - November 10, 2022 Category: Infectious Diseases Source Type: research
Presence of sarcopenia identifies a special group of lean NAFLD in middle-aged and older people
ConclusionThe presence of sarcopenia identifies a special subgroup of lean NAFLD with increased risk of cardiovascular disease and liver fibrosis clinically.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - November 3, 2022 Category: Infectious Diseases Source Type: research
Comparison of the prognostic models for mortality in idiosyncratic drug-induced liver injury
ConclusionDespite the difference of clinical characteristics and implicated-drug categories between China and industrialized countries, we demonstrate that MELD Score and Ghabril Model have the best predictive performance in the prediction of mortality within 12 months after DILI onset. (Source: Hepatology International)
Source: Hepatology International - November 3, 2022 Category: Infectious Diseases Source Type: research
Clinical application of artificial liver and blood purification: expert consensus recommendations
(Source: Hepatology International)
Source: Hepatology International - November 2, 2022 Category: Infectious Diseases Source Type: research
Predictive power of portal pressure gradient remeasured shortly after transjugular intrahepatic portosystemic shunt
ConclusionsIn cirrhotic patients with variceal bleeding, delayed PPG has higher predictive power for variceal rebleeding than immediate PPG. (Source: Hepatology International)
Source: Hepatology International - November 2, 2022 Category: Infectious Diseases Source Type: research
Hepatitis B: “Treat all” or “Treat select”
(Source: Hepatology International)
Source: Hepatology International - October 31, 2022 Category: Infectious Diseases Source Type: research
Prediction and evaluation of high-risk patients with primary biliary cholangitis receiving ursodeoxycholic acid therapy: an early criterion
ConclusionsXi ’an criterion has a similar or even higher ability to distinguish high-risk PBC patients than other published criteria. Xi’an criterion can facilitate early identification of patients requiring new therapeutic approaches. (Source: Hepatology International)
Source: Hepatology International - October 30, 2022 Category: Infectious Diseases Source Type: research
Prevalence, characteristics, and mortality outcomes of obese and nonobese MAFLD in the United States
ConclusionsNonobese MAFLD constitutes about half of the MAFLD in the United States, especially among males and the elderly. Notably, nonobese MAFLD carries higher mortality than obese MAFLD. Screening and diagnosis of MAFLD should be considered in nonobese populations. (Source: Hepatology International)
Source: Hepatology International - October 29, 2022 Category: Infectious Diseases Source Type: research
Role of pharmacogenetics and tacrolimus dosing in liver transplantation
(Source: Hepatology International)
Source: Hepatology International - October 25, 2022 Category: Infectious Diseases Source Type: research
