Effects of serum branched-chain amino acids on nonalcoholic fatty liver disease and subsequent cardiovascular disease
ConclusionsHigh BCAA levels exacerbate the risk of CHD and CVEs by influencing the occurrence and progression of NAFLD. However, lifestyle interventions could reverse the risk of NAFLD, CHD and CVEs associated with BCAAs. (Source: Hepatology International)
Source: Hepatology International - July 18, 2022 Category: Infectious Diseases Source Type: research

Low skeletal muscle mass is associated with more severe histological features of non-alcoholic fatty liver disease in male
ConclusionsLow ASM% and the presence of a G allele withinPNPLA3 rs738409 is associated with more severe histological features of NAFLD. (Source: Hepatology International)
Source: Hepatology International - July 13, 2022 Category: Infectious Diseases Source Type: research

Non-invasive evaluation of NAFLD and the contribution of genes: an MRI-PDFF-based cross-sectional study
ConclusionsBased on MRI-PDFF, a combination of several specific biomarkers can accurately predict disease status. When the effects of genes on liver steatosis were first quantified by MRI-PDFF, the UQCC1 rs878639 G allele was identified as a protective factor, and the MBOAT7 T allele was identified as a risk only among nonobese individuals. (Source: Hepatology International)
Source: Hepatology International - July 12, 2022 Category: Infectious Diseases Source Type: research

Maternal and perinatal outcome in pregnancies complicated with portal hypertension: a systematic review and meta-analysis
ConclusionOne in ten pregnancies complicated with portal hypertension is diagnosed during pregnancy, and thrombocytopenia is the most common complication. Hepatic decompensation and variceal bleeding remain the most common cause of maternal deaths, with reduced rates of bleeding and its complications reported following the introduction of endoscopic procedures during pregnancy. CPH increases the risk of postpartum hemorrhage, whereas variceal bleeding is higher among NCPH. (Source: Hepatology International)
Source: Hepatology International - July 8, 2022 Category: Infectious Diseases Source Type: research

Complications of congenital portosystemic shunts: liver tumors are affected by shunt severity, but pulmonary and neurocognitive associations are not
ConclusionsSeverity of portal venous deprivation (Type 1 CPSS) increases the risk of hepatic tumors and surgical closure is associated with a reduction in size or complete resolution of benign tumors. (Source: Hepatology International)
Source: Hepatology International - July 8, 2022 Category: Infectious Diseases Source Type: research

Tenofovir Alafenamide use in pregnant women with chronic hepatitis B virus infection: more data needed
(Source: Hepatology International)
Source: Hepatology International - July 6, 2022 Category: Infectious Diseases Source Type: research

HBV in pregnancy: time to consider tenofovir alafenamide (TAF)
(Source: Hepatology International)
Source: Hepatology International - July 6, 2022 Category: Infectious Diseases Source Type: research

CT-based visual grading system for assessment of hepatic steatosis: diagnostic performance and interobserver agreement
ConclusionVGS was reliable and reproducible in assessing HS. It may be useful as a non-invasive and simple tool for comprehensive HS assessment.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - July 5, 2022 Category: Infectious Diseases Source Type: research

The immune microenvironment features and response to immunotherapy in EBV-associated lymphoepithelioma-like cholangiocarcinoma
ConclusionA better understanding of the composition of TIME in EBV-LELCC is critical for predicting the clinical outcomes of ICB treatment.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - July 3, 2022 Category: Infectious Diseases Source Type: research

Machine learning models in the prediction of 1-year mortality in patients with advanced hepatocellular cancer on immunotherapy: a proof-of-concept study
ConclusionML models could predict 1-year cancer-related mortality in HCC patients treated with immunotherapy, which may help to select patients who would benefit from this treatment. (Source: Hepatology International)
Source: Hepatology International - July 2, 2022 Category: Infectious Diseases Source Type: research

A prognostic model of acute-on-chronic liver failure based on sarcopenia
ConclusionWe demonstrate that sarcopenia is a simple and objective indicator for predicting short-term prognosis in patients with ACLF. Moreover, compared to conventional prognostic scores, AMPAS1 is a better model for predicting 90  day adverse outcomes in ACLF patients. (Source: Hepatology International)
Source: Hepatology International - June 30, 2022 Category: Infectious Diseases Source Type: research

SARS-CoV-2 infection and liver involvement
AbstractThe COVID-19 pandemic is the largest public health challenge in living memory. Patients with underlying liver disease have been disproportionately affected, experiencing high morbidity and mortality. In addition, elevated liver enzymes appear to be a risk factor for disease progression, even in the absence of underlying liver disease. Nevertheless, the mechanism of liver injury in SARS-CoV-2 infection remains largely unknown. This review aims to provide an overview of the mechanisms by which SARS-CoV-2 induces liver injury, and the impact of COVID-19 on cirrhosis, alcohol-related liver disease, autoimmune liver dis...
Source: Hepatology International - June 29, 2022 Category: Infectious Diseases Source Type: research

Two-year risedronate treatment for osteoporosis in patients with esophageal varices: a non-randomized clinical trial
ConclusionOral risedronate was effective and did not cause gastrointestinal bleeding in cirrhotic patients with esophageal varices under endoscopic surveillance.Graphic abstract (Source: Hepatology International)
Source: Hepatology International - June 29, 2022 Category: Infectious Diseases Source Type: research

Aspirin for patients after TIPS: an old dog with new tricks?
(Source: Hepatology International)
Source: Hepatology International - June 29, 2022 Category: Infectious Diseases Source Type: research

Abstract
(Source: Hepatology International)
Source: Hepatology International - June 27, 2022 Category: Infectious Diseases Source Type: research