A preoperative scoring system to predict lymph node metastasis in intrahepatic cholangiocarcinoma
ConclusionsOur preoperative LNM score was significantly associated with pathologic or clinical LNM and outperformed MRI-suspicious LN alone. (Source: Hepatology International)
Source: Hepatology International - January 23, 2023 Category: Infectious Diseases Source Type: research
Biomarkers of hepatocellular synthesis in patients with decompensated cirrhosis
ConclusionOur study reveals cirrhosis-associated changes in hepatocellular serum proteins and underlying transcription factors. Serum apolipoprotein AI may constitute a useful prognostic adjunct in patients with decompensated cirrhosis.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - January 18, 2023 Category: Infectious Diseases Source Type: research
Adjuvant anti-PD-1 antibody for hepatocellular carcinoma with high recurrence risks after hepatectomy
ConclusionsAdjuvant anti-PD-1 antibody can effectively improve the survival outcomes of HCC patients with high relapse risks after hepatectomy in this prospective observational study. This finding should be confirmed by results of the ongoing phase 3 randomized controlled trials. (Source: Hepatology International)
Source: Hepatology International - January 16, 2023 Category: Infectious Diseases Source Type: research
Correction to: HMGCL ‑induced β‑hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4‑mediated ferroptosis susceptibility
(Source: Hepatology International)
Source: Hepatology International - January 13, 2023 Category: Infectious Diseases Source Type: research
Genetic landscape and immune mechanism of monocytes associated with the progression of acute-on-chronic liver failure
ConclusionsWe present the accurate classification, molecular markers, and signaling pathways of monocytes associated with ACLF progression. Therapies targeting pro-inflammatory monocytes may be a promising approach for blocking ACLF progression. (Source: Hepatology International)
Source: Hepatology International - January 10, 2023 Category: Infectious Diseases Source Type: research
Comparative efficacy of PD-1 inhibitors plus lenvatinib and regorafenib after lenvatinib failure for advanced hepatocellular carcinoma: a real-world study
(Source: Hepatology International)
Source: Hepatology International - January 7, 2023 Category: Infectious Diseases Source Type: research
Pure laparoscopic versus open left lateral hepatectomy in pediatric living donor liver transplantation: a review and meta-analysis
ConclusionLLDH is a safe and effective alternative to OLDH for pediatric LDLT, reducing invasiveness and benefiting postoperative recovery. Future large-scale multi-center studies are expected to confirm the advantages of LLDH in pediatric LDLT. (Source: Hepatology International)
Source: Hepatology International - January 5, 2023 Category: Infectious Diseases Source Type: research
Identification and development of a novel risk model based on cuproptosis-associated RNA methylation regulators for predicting prognosis and characterizing immune status in hepatocellular carcinoma
ConclusionOverall, our predictive signature displayed potential value in the prediction of overall survival of HCC patients and might provide valuable clues for personalized therapies.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - January 4, 2023 Category: Infectious Diseases Source Type: research
High-potency nucleos(t)ide analogues alone or plus immunoglobulin for HBV prophylaxis after liver transplantation: a meta-analysis
ConclusionA similar HBV recurrence and overall survival were found in patients who used HPNAs (mainly entecavir) monotherapy as in those who received a combination of HPNAs and HBIG. These findings address concerns regarding the safety and effectiveness of HPNAs monotherapy.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - January 2, 2023 Category: Infectious Diseases Source Type: research
Pemafibrate improves liver dysfunction and non-invasive surrogates for liver fibrosis in patients with non-alcoholic fatty liver disease with hypertriglyceridemia: a multicenter study
ConclusionPemafibrate improved LFTs, including fibrotic biomarkers and FAST score, due to the hepatic anti-inflammatory effect, suggesting that pemafibrate may prevent disease progression in NAFLD patients with hypertriglyceridemia. (Source: Hepatology International)
Source: Hepatology International - December 30, 2022 Category: Infectious Diseases Source Type: research
Comparison of hepatitis B virus reactivation in hepatocellular carcinoma patients who received tyrosine kinase inhibitor alone or together with programmed cell death protein-1 inhibitors
ConclusionsPatients who received TKI combined with PD-1 inhibitors had a greater risk for HBV reactivation, and those with HBV reactivation had a higher rate of tumor progression and shorter survival time, than those receiving TKI alone. (Source: Hepatology International)
Source: Hepatology International - December 29, 2022 Category: Infectious Diseases Source Type: research
The differences in post-liver transplant outcomes of patients with autoimmune hepatitis who present with overlapping autoimmune liver diseases
ConclusionPatients with AIH-PBC overlap have higher risk of mortality due to recurrent liver disease and respiratory causes, and patients with AIH-PSC overlap have higher risk of mortality due to graft infection. While further prospective studies are needed to clarify the underlying mechanisms related to these findings, our study characterizes the prognostic implications of AIH overlap on post-LT mortality and graft failure risks. (Source: Hepatology International)
Source: Hepatology International - December 27, 2022 Category: Infectious Diseases Source Type: research
Establishment and validation of a prediction model for the first recurrence of Budd –Chiari syndrome after endovascular treatment: a large sample size, single-center retrospective study
ConclusionLiver cirrhosis, ascites, thrombosis, and obstructed HV + AHV are independent risk factors for the first recurrence; age is an independent protective factor. The prediction model can effectively and conveniently predict the risk of recurrence and screen out patients at a high recurrence risk. (Source: Hepatology International)
Source: Hepatology International - December 26, 2022 Category: Infectious Diseases Source Type: research
AARC score determines outcomes in patients with alcohol-associated hepatitis: a multinational study
ConclusionNearly 4 of 5 patients with AH present with ACLF. Such patients have a higher risk of infections, organ failures, lower response to CS, and higher mortality. Patients with AH and ACLF with AARC grade 3 should be considered for an early liver transplant. (Source: Hepatology International)
Source: Hepatology International - December 26, 2022 Category: Infectious Diseases Source Type: research
Developing real-world prognostic models for patients with advanced hepatocellular carcinoma: CRAFITY, mALF and beyond
(Source: Hepatology International)
Source: Hepatology International - December 24, 2022 Category: Infectious Diseases Source Type: research
