A simpler definition of MAFLD precisely predicts incident metabolic diseases: a 7-year cohort study
ConclusionThe MAFLD-simplified criteria are an optimized risk stratification tool for predicting metabolic diseases in fatty liver individuals. (Source: Hepatology International)
Source: Hepatology International - June 15, 2023 Category: Infectious Diseases Source Type: research
Diagnostic yield and novel candidate genes by next generation sequencing in 166 children with intrahepatic cholestasis
ConclusionsIn a single-center pediatric cohort, we identified monogenic variants in 22 known human intrahepatic cholestasis or phenocopy genes, explaining up to 31% of the intrahepatic cholestasis patients. Our findings suggest that re-evaluating existing WES data from well-phenotyped patients on a regular basis can increase the diagnostic yield for cholestatic liver disease in children. (Source: Hepatology International)
Source: Hepatology International - June 14, 2023 Category: Infectious Diseases Source Type: research
Correction to: Serum interleukin-6 level predicts the prognosis for patients with alcohol-related acute-on-chronic liver failure
(Source: Hepatology International)
Source: Hepatology International - June 12, 2023 Category: Infectious Diseases Source Type: research
Exosome GLUT1 derived from hepatocyte identifies the risk of non-alcoholic steatohepatitis and fibrosis
ConclusionHepatogenic exosome GLUT1 can be a molecular biomarker for early warning of NAFLD to distinguish the NAFL and NASH, and it also can be used as a novel non-invasive diagnostic biomarker for the staging liver fibrosis in NAFLD. (Source: Hepatology International)
Source: Hepatology International - June 6, 2023 Category: Infectious Diseases Source Type: research
Real-world treatment outcome with protease inhibitor direct-acting antiviral in advanced hepatitis C cirrhosis: a REAL-C study
ConclusionTolerability and treatment outcomes were not significantly different in advanced HCV cirrhosis treated with PI-based (vs. non-PI) DAA up to CTP-B or MELD score of 15. Safety of PI-based DAA in those with CTP-C or MELD beyond 15 awaits further data. (Source: Hepatology International)
Source: Hepatology International - June 5, 2023 Category: Infectious Diseases Source Type: research
Molecular evolution in different subtypes of multifocal hepatocellular carcinoma
ConclusionOur study comprehensively characterized the varied tumor clonal evolutionary history underlying different subtypes of MF-HCC and provided important implications for optimizing personalized clinical management for MF-HCC.Graphical abstract (Source: Hepatology International)
Source: Hepatology International - June 5, 2023 Category: Infectious Diseases Source Type: research
Healthcare utilization and outcomes of living donor liver transplantation for patients with APASL-defined acute-on-chronic liver failure
ConclusionsLDLT was associated with 73% survival and, thus, is a viable option in those with APASL-defined ACLF. There was a pre-LT high healthcare resource utilization of plasma exchange, with the intention of optimization, while survival benefit has not been demonstrated. (Source: Hepatology International)
Source: Hepatology International - June 5, 2023 Category: Infectious Diseases Source Type: research
Reply to: “developing real‑world prognostic models for patients with advanced hepatocellular carcinoma: CRAFITY, mALF and beyond”
(Source: Hepatology International)
Source: Hepatology International - June 3, 2023 Category: Infectious Diseases Source Type: research
Polypill protects MAFLD patients from cardiovascular events and mortality: a prospective trial
ConclusionsMajor cardiovascular events are prevented in MAFLD patients who consume the Polypill. MAFLD patients benefit from the Polypill more than the general population. (Source: Hepatology International)
Source: Hepatology International - May 25, 2023 Category: Infectious Diseases Source Type: research
Whole-exome sequencing reveals the metastatic potential of hepatocellular carcinoma from the perspective of tumor and circulating tumor DNA
ConclusionsWe characterized the genomic alterations during HCC vascular invasion and revealed a previously undescribed evolution pattern of ctDNA in HCC. A novel multiomics-based signature was developed to identify high-risk relapse populations. (Source: Hepatology International)
Source: Hepatology International - May 23, 2023 Category: Infectious Diseases Source Type: research
Clinical characteristics and prognosis of non-APAP drug-induced acute liver failure: a large multicenter cohort study
ConclusionsBased on easily identifiable clinical data, the novel DIALF-5 model was developed to predict transplant-free survival in non-APAP drug-induced ALF, which was superior to KCC, MELD and had a similar prediction performance to ALFSG-PI but is more convenient, which can directly calculate TFS at multiple time points. (Source: Hepatology International)
Source: Hepatology International - May 19, 2023 Category: Infectious Diseases Source Type: research
An international multidisciplinary consensus statement on MAFLD and the risk of CVD
AbstractBackgroundFatty liver disease in the absence of excessive alcohol consumption is an increasingly common condition with a global prevalence of ~ 25–30% and is also associated with cardiovascular disease (CVD). Since systemic metabolic dysfunction underlies its pathogenesis, the term metabolic (dysfunction)-associated fatty liver disease (MAFLD) has been proposed for this condition. MAFLD is closely intertwined with obesity, type 2 d iabetes mellitus and atherogenic dyslipidemia, which are established cardiovascular risk factors. Unlike CVD, which has received attention in the literature on fatty liver disease...
Source: Hepatology International - May 19, 2023 Category: Infectious Diseases Source Type: research
Targeting NAD+ metabolism of hepatocellular carcinoma cells by lenvatinib promotes M2 macrophages reverse polarization, suppressing the HCC progression
ConclusionsTargeting HCC cells NAD+ metabolism by lenvatinib-TET2 pathway drives metabolite crosstalk, leading to M2 macrophages reverse polarization, thereby suppressing HCC progression. Collectively, these novel insights highlight the role of lenvatinib or its combination therapies as promising therapeutic alternatives for HCC patients with low NAD+ levels or high TET2 levels. (Source: Hepatology International)
Source: Hepatology International - May 19, 2023 Category: Infectious Diseases Source Type: research
Clinic-radiomics model using liver magnetic resonance imaging helps predict chronicity of drug-induced liver injury
ConclusionThe clinic-radiomics model yielded sufficient accuracy for predicting chronic DILI, providing a practical and non-invasive tool for managing DILI patients. (Source: Hepatology International)
Source: Hepatology International - May 15, 2023 Category: Infectious Diseases Source Type: research
Obesity and non-alcoholic steatohepatitis in immunotherapy for hepatocellular carcinoma
(Source: Hepatology International)
Source: Hepatology International - May 15, 2023 Category: Infectious Diseases Source Type: research
