Diagnostic performance of diffusion-weighted magnetic resonance imaging in assessing lymph node metastasis of esophageal cancer compared with PET
This study aimed to clarify the diagnostic performance of DWI for assessing LN metastasis compared with positron emission tomography (PET) in patients with esophageal squamous cell cancer (eSCC).MethodsSeventy-six patients with histologically proven eSCC who underwent curative esophagectomy without neoadjuvant treatment were reviewed retrospectively. Harvested LNs were divided into 1229 node stations with 94 metastases. Diagnostic abilities and prognostic significance were compared.ResultsIn a station-by-station evaluation, the sensitivity was higher in DWI than PET (67% vs. 32%,P  
Source: Esophagus - December 9, 2019 Category: Gastroenterology Source Type: research

The decrease of BMI and albumin levels influences the rate of anastomotic leaks in patients following reconstruction after emergency diverting esophagectomy
ConclusionsThe relative amount of malnutrition indicated by BMI or serum albumin levels influences the rate of anastomotic leaks and general complications in patients with staged reconstruction after diverting esophagectomy for non-malignant esophageal perforations. Hence, reconstruction should be done as fast as possible to reduce the amount of malnutrition and a frequent assessment of the nutritional status must be done during recovery from the emergency surgery. (Source: Esophagus)
Source: Esophagus - November 28, 2019 Category: Gastroenterology Source Type: research

The sterno-tracheal distance is an important factor of anastomotic leakage of retrosternal gastric tube reconstruction after esophagectomy
ConclusionThe STD was the independent risk factor for AL in the RS route. RS route reconstruction should be avoided for the patients with STD  
Source: Esophagus - November 27, 2019 Category: Gastroenterology Source Type: research

Chemokines and their receptors as biomarkers in esophageal cancer
AbstractEsophageal cancer (EC) is one of the most lethal malignancies of the digestive tract and remains to be improved poor prognosis. Two histological subtypes, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), are major characteristics of EC. Deep understanding about both subtypes is essential to overcome EC. Here, we focus on chemokines and their receptors as biomarkers and their current applications for the prognosis in EC. We reviewed relevant articles identified using PubMed database for the chemokines and their receptors in EC analyzed by immunohistochemistry. The primary objective is t...
Source: Esophagus - November 26, 2019 Category: Gastroenterology Source Type: research

Risk of hemorrhage and stricture significantly increases in elderly patients with proton pump inhibitor (PPI)-resistant reflux esophagitis
ConclusionAmong patients with proton pump inhibitor-resistant reflux esophagitis, the rates of severe reflux esophagitis and complications (hemorrhage and/or stricture) were significantly higher in elderly patients than in non-elderly patients. Regardless of age, 20  mg vonoprazan was effective for proton pump inhibitor-resistant reflux esophagitis. (Source: Esophagus)
Source: Esophagus - November 2, 2019 Category: Gastroenterology Source Type: research

Remaining challenges for the noninvasive diagnosis of esophageal varices in liver cirrhosis
AbstractAlthough endoscopy is the recommended method for detecting esophageal varices, noninvasive methods for diagnosing esophageal varices are needed to avoid unnecessary invasive endoscopic examinations. In recent years, many studies have been performed to predict the presence of high-risk varices in noninvasive ways. The most widely used tools for noninvasive screening for esophageal varices are the Baveno VI and expanded Baveno VI criteria. Even these accepted criteria are not 100% accurate and have some limitations. Here, we summarize the current literature on the noninvasive diagnosis of esophageal varices in liver ...
Source: Esophagus - October 16, 2019 Category: Gastroenterology Source Type: research

Clinical outcomes of gastroesophageal reflux disease-related chronic cough following antireflux fundoplication
ConclusionsAntireflux surgery, although less predictable, is effective for the treatment of gastroesophageal reflux disease-related chronic cough. (Source: Esophagus)
Source: Esophagus - October 15, 2019 Category: Gastroenterology Source Type: research

Peroral endoscopic myotomy for esophageal motility disorders
ConclusionsPOEM can be a new option for the treatment of esophageal movement disorders, but large sample, multi-center, long-term study reports are needed, and it promotes the development of NOTES technology. (Source: Esophagus)
Source: Esophagus - October 12, 2019 Category: Gastroenterology Source Type: research

Immunohistochemical analysis of tumor budding as predictor of lymph node metastasis from superficial esophageal squamous cell carcinoma
ConclusionsTumor budding was significantly associated with lymph node metastasis. The optimal cut-off values of tumor budding on HE staining and tumor budding on IHC were 2 and 11, respectively. Even though both tumor budding on HE staining and tumor budding on IHC were significantly associated with lymph node metastasis, tumor budding on IHC tend to be more associated with lymph node metastasis. (Source: Esophagus)
Source: Esophagus - October 8, 2019 Category: Gastroenterology Source Type: research

Salvage esophagectomy for initially unresectable locally advanced T4 esophageal squamous cell carcinoma
AbstractBackgroundDefinitive chemoradiotherapy (dCRT) for esophageal squamous cell carcinoma (ESCC) is a potentially curative treatment modality, even for patients with unresectable T4 tumors. For patients who fail dCRT, salvage esophagectomy is known to be a high-risk procedure. However, the efficacy and safety of salvage surgery for these patients remain unclear.MethodsA total of 35 patients who underwent salvage esophagectomy after dCRT for initially unresectable locally advanced T4 ESCC were assessed, and both outcomes and prognostic factors after surgery were investigated.ResultsAmong the study population, R0 resectio...
Source: Esophagus - October 8, 2019 Category: Gastroenterology Source Type: research

Chondromodulin-1 and vascular endothelial growth factor-A expression in esophageal squamous cell carcinoma: accelerator and brake theory for angiogenesis at the early stage of cancer progression
ConclusionAngiogenesis at the early stage of ESCC progression is configured by the balance between accelerator (angiogenic factors from both cancer cells and SMCs) and brake (angiogenic inhibitor) factors. (Source: Esophagus)
Source: Esophagus - October 8, 2019 Category: Gastroenterology Source Type: research

Thoracic endovascular aortic repair for esophageal cancer invading the thoracic aorta: a questionnaire survey study
ConclusionTEVAR is an efficacious modality to control a life-threatening hemorrhage from esophagoaortic fistula and helps to prolong the survival of patients with locally advanced esophageal cancer invading the aorta. (Source: Esophagus)
Source: Esophagus - October 5, 2019 Category: Gastroenterology Source Type: research

Therapeutic efficacy of laparoscopic Heller-Dor surgery for chest pain in patients with achalasia: a single institutional experience
ConclusionsLHD improved chest pain symptoms in 90% of patients with achalasia. The patients who achieved relief of chest pain were characterized by disease duration over 60  months and less than two previous balloon dilatations. (Source: Esophagus)
Source: Esophagus - October 4, 2019 Category: Gastroenterology Source Type: research

Impact of certification status of the institute and surgeon on short-term outcomes after surgery for thoracic esophageal cancer: evaluation using data on 16,752 patients from the National Clinical Database in Japan
ConclusionsThe certification system for surgeons and institutes established by the JES appears to be appropriate, as indicated by the improved surgery-related mortality rate. It also appears that the JES certification system contributes to a more appropriate medical delivery system for thoracic esophageal cancer in Japan. (Source: Esophagus)
Source: Esophagus - October 3, 2019 Category: Gastroenterology Source Type: research

Statement for gastroesophageal reflux disease after peroral endoscopic myotomy from an international multicenter experience
AbstractIt has been 10  years since peroral endoscopic myotomy (POEM) was reported for the first time, and POEM has currently become the standard treatment for achalasia and related disorders globally because it is less invasive and has a higher curative effect than conventional therapeutic methods. However, there are li mited studies comparing the long-term outcomes of POEM with those of conventional therapeutic methods, particularly in the occurrence of gastroesophageal reflux disease (GERD) after therapy. With this background, we held a consensus meeting to discuss the pathophysiology and management of GERD after P...
Source: Esophagus - September 26, 2019 Category: Gastroenterology Source Type: research

Analysis of fistula formation of T4 esophageal cancer patients treated by chemoradiotherapy
This study assessed the risk factors of fistula based on clinical information on patients with chemoradiotherapy for T4-EC.MethodsWe retrospectively reviewed the clinical data of 59 T4-EC patients who had squamous cell carcinoma without any fistula before receiving definitive or palliative chemoradiotherapy.ResultsA fistula was observed in 18 patients (31%) throughout their clinical course. The overall survival in the fistula group was significantly shorter than that in the non-fistula group (259 vs. 346  days;p = 0.0341). The axial tumor size on computed tomography (CT) was confirmed as an independent r...
Source: Esophagus - September 10, 2019 Category: Gastroenterology Source Type: research

Determination of the optimal surgical procedure by identifying risk factors for pneumonia after transthoracic esophagectomy
ConclusionsA low FEV1.0 and an open thoracotomy are risk factors for POP. Therefore, patients with low FEV1.0 should be managed carefully and video-assisted thoracic surgery should be considered. (Source: Esophagus)
Source: Esophagus - September 9, 2019 Category: Gastroenterology Source Type: research

Current status of radiotherapy for patients with thoracic esophageal cancer in Japan, based on the Comprehensive Registry of Esophageal Cancer in Japan from 2009 to 2011 by the Japan Esophageal Society
AbstractBackgroundAlthough esophagectomy is the standard treatment for resectable esophageal cancer, chemoradiotherapy or radiotherapy alone is also selected for some cases. However, there have been very few detailed studies conducted on a large scale on the efficacy of these treatments in Japan.MethodsOf the patients enrolled in the Comprehensive Registry of Esophageal Cancer in Japan by the Japan Esophageal Society for the 2015 –2017 surveys (patients treated between 2009 and 2011), the data of 388 patients treated by definitive radiotherapy alone (RTx) and 1964 patients treated by definitive chemoradiotherapy (CRT...
Source: Esophagus - August 31, 2019 Category: Gastroenterology Source Type: research

Safety and oncological efficacy of bilateral recurrent laryngeal nerve lymph-node dissection after neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma: a propensity-matched analysis
ConclusionsRLN LND can be safely performed in ESCC patients who had undergone nCRT, ultimately resulting in an improved local control, and should be practiced as part of the surgical routine. (Source: Esophagus)
Source: Esophagus - August 19, 2019 Category: Gastroenterology Source Type: research

Eosinophilic esophagitis: time for clinical practice
(Source: Esophagus)
Source: Esophagus - August 5, 2019 Category: Gastroenterology Source Type: research

A retrospective study of definitive chemoradiotherapy in patients with resectable small cell neuroendocrine carcinoma of the esophagus
ConclusionsDefinitive CRT with cisplatin and etoposide or carboplatin and etoposide is a feasible treatment for the resectable SCNEC-E, and long-term survival can be achieved in some patients. (Source: Esophagus)
Source: Esophagus - July 18, 2019 Category: Gastroenterology Source Type: research

Association between macrocytosis and metachronous squamous cell carcinoma of the esophagus after endoscopic resection in men with early esophageal squamous cell carcinoma
AbstractBackgroundMacrocytosis is associated with an increased risk of squamous cell carcinoma (SCC) arising in the esophagus in men. The aim of this study was to evaluate the association between macrocytosis and metachronous SCC of the esophagus after endoscopic resection (ER) of early esophageal SCC in men.MethodsThe study group comprised 278 men with early esophageal SCC after ER. The main study variables were as follows: (1) cumulative incidence and total number of metachronous SCC of the esophagus according to the presence or absence of macrocytosis (mean corpuscular volume  ≥ 106 fl) and (2) pre...
Source: Esophagus - July 8, 2019 Category: Gastroenterology Source Type: research

Changes in the nutritional status of elderly patients after esophagectomy
AbstractBackgroundEsophagectomy is a highly invasive procedure for patients aged  >  70 years. Here, we compared the actual nutritional status of older and younger patients who underwent esophagectomy.MethodsA total of 118 patients who underwent radical esophagectomy between April 2013 and December 2016 were enrolled and divided into two groups based on age: group A (n = 41; ≥ 70 years) and group B (n = 77;   70 years can recover within 12 months of esophagectomy. (Source: Esophagus)
Source: Esophagus - June 26, 2019 Category: Gastroenterology Source Type: research

Possible new endoscopic finding in patients with achalasia: “Gingko leaf sign”
AbstractBackgroundThe diagnosis of achalasia can occasionally be difficult because of the low prevalence of apparent endoscopic abnormal findings, such as dilation and food residue, and lack of “esophageal rosette” in some patients. We have found a new endoscopic finding “Gingko leaf sign”, which consists of not being able to see the full extent of the esophageal palisade vessels and a Gingko leaf-shaped morphology of a longitudinal section of the esophagogastric junction at the en d of a deep inspiration, in some achalasia patients without “esophageal rosette”. The aim of the study was ...
Source: Esophagus - June 21, 2019 Category: Gastroenterology Source Type: research

Treatment of aortoesophageal fistula developed after thoracic endovascular aortic repair: a questionnaire survey study
AbstractBackgroundAortoesophageal fistula (AEF) is a life-threatening late complication that can occur after thoracic endovascular aortic repair (TEVAR). More data are required to identify the optimal treatment strategy for AEF developed after TEVAR. The aim of this study was to clarify the current status of surgical treatments for AEF developed after TEVAR and the outcomes of these treatments.MethodsThe Japan Esophageal Society conducted a questionnaire survey targeting authorized or semi-authorized institutes at Authorized Institutes for Board Certified Esophageal Surgeons. Thirty-nine patients with AEF developed after T...
Source: Esophagus - June 20, 2019 Category: Gastroenterology Source Type: research

Gastric mucosal injury and hemorrhage after definitive chemoradiotherapy for locally advanced esophageal cancer
ConclusionsIt is important to consider gastric mucosal injury in patients who receive CRT, particularly when the irradiation field includes stomach. (Source: Esophagus)
Source: Esophagus - June 20, 2019 Category: Gastroenterology Source Type: research

The impact of epidural catheter insertion level on pain control after esophagectomy for esophageal cancer
AbstractBackgroundAlthough the effectiveness of epidural anesthesia on pain control after esophagectomy has been reported, the appropriate insertion level of the epidural catheter remains unclear for adequate postoperative pain control. We investigated the relationship between the epidural catheter insertion level and postoperative pain control after esophagectomy for esophageal cancer.MethodsWe analyzed retrospectively 63 patients who underwent McKeown esophagectomy for esophageal cancer between October 2014 and November 2018. The epidural catheter was inserted at the T4 –T10 level before general anesthesia inductio...
Source: Esophagus - June 20, 2019 Category: Gastroenterology Source Type: research

Prognostic significance of pathological tumor response and residual nodal metastasis in patients with esophageal squamous cell carcinoma after neoadjuvant chemotherapy followed by surgery
AbstractBackgroundThe present study investigated prognostic factors in patients with resectable locally advanced esophageal squamous cell carcinoma (ESCC) among various clinicopathological features related to neoadjuvant chemotherapy (NAC) and surgery, and the indications for additional treatment after surgery were considered.MethodsA total of 113 patients with clinical stage II or III ESCC, who had undergone NAC followed by a thoracic esophagectomy with a three-field lymphadenectomy were retrospectively reviewed. NAC consisted of either two courses of cisplatin and 5-fluorouracil or three courses of docetaxel, cisplatin a...
Source: Esophagus - June 12, 2019 Category: Gastroenterology Source Type: research

A low surgical Apgar score is a predictor of anastomotic leakage after transthoracic esophagectomy, but not a prognostic factor
This study aimed to examine the utility of SAS as a predictor of major complications, particularly anastomotic leakage, in patients who underwent transthoracic esophagectomy, and investigate the correlation between SAS and patient prognosis.MethodsThis is a single-center, retrospective observational study. A total of 190 patients who underwent esophagectomy for esophageal cancer in 2012 –2016 were reviewed to find the correlation between SAS and postoperative complications (Clavien–Dindo classification III or higher). SAS was calculated based on intraoperative estimated blood loss, lowest mean arterial pressure...
Source: Esophagus - June 5, 2019 Category: Gastroenterology Source Type: research

Efficacy of long-term maintenance therapy with 10-mg vonoprazan for proton pump inhibitor-resistant reflux esophagitis
ConclusionLong-term maintenance therapy by 10-mg vonoprazan administration is very effective for proton pump inhibitor-resistant reflux esophagitis patients in whom endoscopic healing was maintained by 8  weeks maintenance therapy with 10-mg vonoprazan administration. (Source: Esophagus)
Source: Esophagus - May 22, 2019 Category: Gastroenterology Source Type: research

Comparing the 7th and 8th editions of the American Joint Committee on Cancer/Union for International Cancer Control TNM staging system for esophageal squamous cell carcinoma treated by definitive radiotherapy
ConclusionsThe 8th edition of AJCC/UICC TNM classification is a useful predictor of OS among ESCC patients who were treated with definitive radiotherapy. (Source: Esophagus)
Source: Esophagus - May 20, 2019 Category: Gastroenterology Source Type: research

Ivor –Lewis esophagectomy for patients with squamous cell carcinoma of the thoracic esophagus with a history of total pharyngolaryngectomy
ConclusionIvor –Lewis esophagectomy for patients with a history of TPL is a safe procedure, which can prevent severe complications including anastomotic leakage or tracheal necrosis. (Source: Esophagus)
Source: Esophagus - May 18, 2019 Category: Gastroenterology Source Type: research

Comprehensive registry of esophageal cancer in Japan, 2012
(Source: Esophagus)
Source: Esophagus - May 16, 2019 Category: Gastroenterology Source Type: research

Use of esophageal stent for the treatment of postoperative gastrointestinal –airway fistula after esophagectomy
In conclusion, ESP was shown to be a less-invasiv e and effective therapeutic modality for the treatment of GAF. (Source: Esophagus)
Source: Esophagus - May 6, 2019 Category: Gastroenterology Source Type: research

Predictive factors of difficulty of thoracoscopic esophagectomy in the left decubitus position
In this study, we retrospectively investigated predictive preoperative factors that influence the procedure of thoracoscopic esophagectomy with a focus on the position of the descending aorta and width of the mediastinal space.MethodsNinety-five patients who underwent thoracoscopic esophagectomy for esophageal cancer by two specialists were included in this study. Thirty patients in whom both the operation time and blood loss in the thoracic region exceeded the median were categorized to the difficult group. The remaining 65 patients were categorized into the common group. During the evaluation of the position of the desce...
Source: Esophagus - April 30, 2019 Category: Gastroenterology Source Type: research

Significance of the board-certified surgeon systems and clinical practice guideline adherence to surgical treatment of esophageal cancer in Japan: a questionnaire survey of departments registered in the National Clinical Database
AbstractBackgroundIt remains unknown how much institutional medical structure and process of implementation of clinical practice guidelines for esophageal cancers can improve quality of surgical outcome in Japan.MethodsA web-based questionnaire survey was performed for departments registered in the National Clinical Database in Japan from October 2014 to January 2015. Quality indicators (QIs) including structure and process indicators (clinical practice guideline adherence) were evaluated on the risk-adjusted odds ratio for operative mortality (AOR) of the patients using registered cases in the database who underwent esoph...
Source: Esophagus - April 12, 2019 Category: Gastroenterology Source Type: research

Evaluation of the impact of psoas muscle index, a parameter of sarcopenia, in patients with esophageal squamous cell carcinoma receiving neoadjuvant therapy
ConclusionsThe PMI may decrease during neoadjuvant therapy, especially during neoadjuvant chemoradiotherapy. Pretherapeutic sarcopenic (low PMI) patients should be followed-up more carefully postoperatively because higher risks of recurrence and poorer rates of disease-free survival are associated with these patients. (Source: Esophagus)
Source: Esophagus - April 12, 2019 Category: Gastroenterology Source Type: research

Evaluation of the efficacy of Hypericum perforatum (St. John ’s wort) oil in the prevention of stricture due to esophageal corrosive burns
ConclusionsSome of the experimental indicators such as weight gain and stenosis index suggested the treatment of esophageal injury models using extracts of St. John ’s wort effective while other histopathological indicators show no significant benefit. (Source: Esophagus)
Source: Esophagus - April 11, 2019 Category: Gastroenterology Source Type: research

Impact of tumor-infiltrating LAMP-3 dendritic cells on the prognosis of esophageal squamous cell carcinoma
ConclusionAt the local tumor site, mature LAMP-3 DCs might be associated with increasing tumor infiltrating CD8 T cells. (Source: Esophagus)
Source: Esophagus - April 9, 2019 Category: Gastroenterology Source Type: research

Palliative interventions for patients with incurable locally advanced or metastatic thoracic esophageal carcinoma
AbstractBackgroundThe aim of this study was to assess the clinical outcomes of palliative interventions for patients with incurable locally advanced or metastatic esophageal carcinoma.MethodsA total of 131 patients with thoracic esophageal carcinoma who underwent palliative interventions were enrolled. Insertion of a self-expandable metallic stent (SEMS), tube enterostomy for enteral nutrition (EN), and palliative esophagectomy (PE) were performed in 38, 65, and 28 patients, respectively. The clinicopathological characteristics and clinical outcomes of each group were retrospectively reviewed.ResultsPatients in the EN grou...
Source: Esophagus - April 4, 2019 Category: Gastroenterology Source Type: research

Is complete right cervical paraesophageal lymph node dissection possible in the prone position during thoracoscopic esophagectomy?
ConclusionsThere were no residual LNs in the area ventral to the right cervical RLN in 64% of the patients who underwent additional cervical lymphadenectomy after the right thoracoscopic approach in the prone position. Further studies with larger patient cohort or randomization are required to confirm our results. (Source: Esophagus)
Source: Esophagus - April 3, 2019 Category: Gastroenterology Source Type: research

Change in tongue pressure and the related factors after esophagectomy: a short-term, longitudinal study
AbstractBackgroundDysphagia is a prominent symptom after esophagectomy and may cause aspiration pneumonia. Swallowing evaluation after esophagectomy can predict and help control the incidence of postoperative pneumonia. The aim of this study was to clarify whether the change in tongue pressure was associated with any related factor and postoperative dysphagia/pneumonia in patients with esophageal cancer after esophagectomy.MethodsFifty-nine inpatients (41 males and 18 females; 33 –77 years old) who underwent esophagectomy participated in this study. Measurement of tongue pressure and the repetitive saliva swallo...
Source: Esophagus - April 2, 2019 Category: Gastroenterology Source Type: research

Prognosis and prognostic factors of esophageal spindle cell carcinoma treated by esophagectomy: a retrospective single-institution analysis
ConclusionThe 5-year OS of ESpCC mainly treated with surgical therapy was 61.9%. However, prognosis was poor in some patients with ulcerative-type ESpCC according to macroscopic type. In the future, it will be necessary to accumulate more cases and investigate therapeutic strategies added to surgery to improve prognosis. (Source: Esophagus)
Source: Esophagus - April 1, 2019 Category: Gastroenterology Source Type: research

Efficacy of novel sedation using the combination of dexmedetomidine and midazolam during endoscopic submucosal dissection for esophageal squamous cell carcinoma
ConclusionsThe combination of DEX and midazolam provided effective sedation for ESD for ESCC. (Source: Esophagus)
Source: Esophagus - April 1, 2019 Category: Gastroenterology Source Type: research

Obesity and hiatal hernia may be non-allergic risk factors for esophageal eosinophilia in Japanese adults
AbstractBackgroundEsophageal eosinophilia (EE) is a basal condition of eosinophilic esophageal disorders including eosinophilic esophagitis (EoE) and asymptomatic EE. EoE is considered as an allergic disorder, while it is unclear whether other non-allergic conditions are involved in the pathophysiology of EE. The aim of this study is to investigate the non-allergic risk factors for EE.MethodsThis cross-sectional study included subjects who underwent esophagogastroduodenoscopy on a medical health check-up. We compared clinical characteristics between subjects with EE (n = 27) and those without EE (n =&t...
Source: Esophagus - March 29, 2019 Category: Gastroenterology Source Type: research

The usefulness of three-dimensional video-assisted thoracoscopic esophagectomy in esophageal cancer patients
ConclusionsAn introduction of 3D-VA endoscopy into minimally invasive esophagectomies may contribute to the shortening of the duration of thoracoscopic procedures. (Source: Esophagus)
Source: Esophagus - March 19, 2019 Category: Gastroenterology Source Type: research

White coat status is a predictive marker for post-esophageal endoscopic submucosal dissection stricture: a retrospective study
This study aimed to clarify the risk factors for esophageal stricture after preventive steroid therapy.MethodsThis was a retrospective study conducted at three institutions. From January 2011 to February 2018, 28 large-sized SENs in 26 patients who had a mucosal defect that involved more than three-quarters of the esophageal circumference were enrolled. We classified white coats on artificial ulcers after esophageal ESD into three groups (thin, moderately thick, thick) based on endoscopic images obtained on postoperative day 7.ResultsThe white coat status on the artificial ulcer after ESD was a significant risk factor for ...
Source: Esophagus - March 5, 2019 Category: Gastroenterology Source Type: research

Host factors influence Barrett ’s carcinogenesis: findings from a mouse gastroduodenal reflux model
ConclusionsWe showed the effects of TCA in cancer progression in vitro. However, Barrett ’s adenocarcinoma onset rates differ between mice and rats despite undergoing similar reflux stimulation including taurine-conjugated bile acids being detected in mouse bile juice. These results suggest that host factors seem to influence Barrett’s carcinogenesis. (Source: Esophagus)
Source: Esophagus - February 21, 2019 Category: Gastroenterology Source Type: research

The effectiveness of serum midkine in detecting esophageal squamous cell carcinoma
Conclusionss-MK and conventional tumor marker combination increased our capability to detect esophageal squamous cell carcinoma. Although s-MK might be associated with esophageal squamous cell carcinoma progression, it was not an independent risk factor reducing patient survival. This study was registered as UMIN000014530. (Source: Esophagus)
Source: Esophagus - February 18, 2019 Category: Gastroenterology Source Type: research

Validation of new Japanese classification system for esophageal achalasia
ConclusionThe new Japanese classification system may give additional insight and information in understanding epidemiology of esophageal achalasia; however, our study failed to demonstrate “inter-disease type” differences in surgical outcomes and prognoses. (Source: Esophagus)
Source: Esophagus - February 15, 2019 Category: Gastroenterology Source Type: research