Oncogenic microRNA-301b regulates tumor repressor dystrobrevin alpha to facilitate cell growth, invasion and migration in esophageal cancer
ConclusionsAbove all, we concluded that miR-301b was concerned with the progression of EC via regulating DTNA, suggesting that miR-301b and its target gene, DTNA, might serve as predictive biomarkers for EC therapy. (Source: Esophagus)
Source: Esophagus - July 31, 2020 Category: Gastroenterology Source Type: research

Relative metabolic tumor burden is associated with residual lymph node status after neoadjuvant chemoradiotherapy in locally advanced esophageal cancer
ConclusionThe preliminary study revealed a great heterogeneity in clinical lymph node categories in esophageal cancer. It suggested that R-MTB was significantly associated with ypN status after neoadjuvant chemoradiotherapy in locally advanced esophageal cancer. The findings with the indications needed to be further studied in a prospective study with a large patient cohort. (Source: Esophagus)
Source: Esophagus - July 31, 2020 Category: Gastroenterology Source Type: research

Association of residual gastric acid secretion with persistent symptoms in gastroesophageal reflux disease patients receiving standard-dose proton pump inhibitor therapy
AbstractBackgroundAlthough a third of gastroesophageal reflux disease (GERD) patients are refractory to proton pump inhibitor (PPI) therapy, the underlying mechanism of the refractoriness remains unclear. We compared the level of gastric acid suppression during PPI treatment between responders and non-responders by directly measuring gastric acid secretion in GERD patients taking PPIs.MethodsSeventy-five consecutive patients receiving standard-dose PPI therapy for GERD were prospectively recruited, irrespective of persistent GERD symptoms. They were asked about their GERD symptoms using a validated questionnaire, and simul...
Source: Esophagus - July 31, 2020 Category: Gastroenterology Source Type: research

Changes in esophageal physiology after paraesophageal hernia repair and Collis gastroplasty
AbstractBackgroundThe surgical approach and technique for paraesophageal hernia (PEH) repair is much debated. The changes in the esophageal physiology after PEH repair with a concomitant Collis gastroplasty (PEH-CG) are not clearly known. The aim of this study was to determine the changes in high resolution esophageal manometry (HREM) and esophageal pH testing after PEH-CG.MethodsRetrospective analysis of all patients who underwent PEH-CG at our institution between 2006 and 2013 was performed. Patients had esophageal pH testing, HREM, barium swallow and an upper endoscopy before and after PEH-CG.ResultsA total of 182 patie...
Source: Esophagus - July 30, 2020 Category: Gastroenterology Source Type: research

Verification of oncological local control for hand-assisted laparoscopic abdominal lymph node dissection in esophageal cancer surgery: a propensity score-matched analysis
ConclusionHALS may be a well-accepted procedure for radical esophagectomy in esophageal cancer, with oncological safety, including local control specific to the abdomen, comparable to that of the conventional OL. (Source: Esophagus)
Source: Esophagus - July 30, 2020 Category: Gastroenterology Source Type: research

Molecular biomarker identification for esophageal adenocarcinoma using endoscopic brushing and magnified endoscopy
ConclusionsThe up-regulation ofCD55 andTOP2A, and the down-regulation ofSCNN1B were common to the brushing samples and might serve as molecular biomarkers for identifying EAC in patients with SSBE.Trial registrationUniversity Hospital Medical Information Network (UMIN) (000004004). (Source: Esophagus)
Source: Esophagus - July 29, 2020 Category: Gastroenterology Source Type: research

Clinical impact of preoperative serum p53 antibody titers in 1487 patients with surgically treated esophageal squamous cell carcinoma: a multi-institutional study
ConclusionThe presence of s-p53-Abs was associated with tumor progression. Although high s-p53-Ab titers more than 9.82 U/ml, might be associated with poor prognosis for patients with esophageal squamous cell carcinoma, it was not an independent risk factor. (Source: Esophagus)
Source: Esophagus - July 26, 2020 Category: Gastroenterology Source Type: research

Review of clinical results of charged-particle therapy for esophageal cancer
The objective of this study was to review the clinical results of charged-particle therapy for esophageal cancer. Charged-particle therapy was used with an expectation of increasing overall survival with reducing toxicities because charged-particle therapy can reduce the irradiated dose for normal tissues around the target tumor due to its characteristics, hence the name Bragg peak. Proton beam therapy showed a superior distribution of irradiation dose over X-ray therapy including intensity-modulated radiotherapy in silico, but clinical results were not the same. Some reports suggested that proton beam therapy may reduce a...
Source: Esophagus - July 11, 2020 Category: Gastroenterology Source Type: research

Submucosal gland neoplasms of the esophagus: an update and review
AbstractSubmucosal glands (SMGs) present throughout human esophagus with clusters at either the upper third or lower third of the organ. SMGs tend to atrophy with age, and neoplasms arising in these glands are rare. In order to bring convenience to diagnosis, we summarize the histopathologic characteristics of all esophageal submucosal gland tumors (SGTs). Due to the morphological similarity, the nomenclature of salivary tumors is adopted for SGTs. However, there is great confusion about the definition and histogenesis of these tumors, especially the malignant subtypes. In the literature, esophageal mucoepidermoid carcinom...
Source: Esophagus - July 3, 2020 Category: Gastroenterology Source Type: research

Efficacy of enhanced prehabilitation for patients with esophageal cancer undergoing esophagectomy
In this study, we investigated the safety and efficacy of enhanced prehabilitation (EP) in the hospital for patients with esophageal cancer.MethodsWe retrospectively reviewed the data of 48 consecutive patients who underwent radical esophagectomy with gastric tube reconstruction between September 2015 and June 2019. EP program had been introduced in August 2017. In the EP group, patients received the EP program during hospitalization 7  days before surgery in addition to conventional perioperative rehabilitation. The EP program consisted of aerobic exercise and muscle strength training in the morning and afternoon. Op...
Source: Esophagus - July 1, 2020 Category: Gastroenterology Source Type: research

Simple technique of azygos arch division and retraction for minimally invasive esophagectomy
AbstractThe azygos arch is usually divided during esophagectomy. To achieve thorough lymphadenectomy up to upper mediastinum, many surgeons prefer to retract the distal stump of the azygos arch by pulling out the thread which ligates the stump to the skin through the dorsal side of the intercostal space. However, the access to the dorsal chest wall near vertebrae for percutaneous puncture is difficult during robot-assisted minimally invasive esophagectomy in the prone position. This paper reports a new simple method of azygos arch division and retraction using a polymer locking ligation system Hem-o-lok (Teleflex, Morrisvi...
Source: Esophagus - July 1, 2020 Category: Gastroenterology Source Type: research

Is esophageal manometry essential for the diagnosis of achalasia? Identifying patients with achalasia by the esophageal clearance method
AbstractBackground and aimAchalasia is a disease characterized by inadequate relaxation of the lower esophageal sphincter (LES) and impaired peristalsis, for which esophageal motor function testing is essential in making a definitive diagnosis. However, the diffusion rate of esophageal pressure testing in Japan is low. We, therefore, examined whether achalasia could be identified by esophageal clearance testing with low-density barium (Timed Barium Esophagogram: TBE).Materials and methods126 cases (62 males, median age of 46  years), excluding those who had not undergone TBE during their initial laparoscopic Heller-Do...
Source: Esophagus - June 17, 2020 Category: Gastroenterology Source Type: research

A message from the new editor-in-chief
(Source: Esophagus)
Source: Esophagus - June 16, 2020 Category: Gastroenterology Source Type: research

The treatment efficacy of adding prokinetics to PPIs for gastroesophageal reflux disease: a meta-analysis
AbstractBackgroundGastroesophageal reflux disease (GERD) is a common gastrointestinal disorder. Proton pump inhibitors (PPIs) are first-line drugs for GERD. For those who fail to respond to PPIs, adding prokinetics to PPIs is recommended and several trials have been conducted to evaluate the efficacy of prokinetic –PPI combination therapy.MethodsA systematic literature search was performed using PubMed and the Cochrane Library databases before February 2019 for randomized controlled trials (RCTs), which compared the efficacy of prokinetics plus PPI treatment with that of PPI monotherapy. Relevant studies were examine...
Source: Esophagus - June 10, 2020 Category: Gastroenterology Source Type: research

Influence of preoperative chemotherapy-induced leukopenia on survival in patients with esophageal squamous cell carcinoma: exploratory analysis of JCOG9907
AbstractBackgroundThe relationship between chemotherapy-induced leukopenia (CIL) and survival has not been investigated in patients undergoing preoperative chemotherapy for esophageal squamous cell carcinoma (ESCC). We analyzed the association of CIL with survival outcomes using data from JCOG9907 on the efficacy of preoperative chemotherapy for stage II/III ESCC.MethodsPreoperative chemotherapy consisted of two courses of 5-FU (800  mg/m2 days 1 –5) and cisplatin (80 mg/m2 day 1) repeated every 3  weeks. Patients in the preoperative chemotherapy arm receiving at least one course of chemotherapy and un...
Source: Esophagus - June 8, 2020 Category: Gastroenterology Source Type: research

Relationship between the microvascular patterns observed by magnifying endoscopy with narrow-band imaging and the depth of invasion in superficial pharyngeal squamous cell carcinoma
ConclusionsMicrovascular patterns observed by M-NBI are an important factor in predicting the pathological depth of invasion. (Source: Esophagus)
Source: Esophagus - June 8, 2020 Category: Gastroenterology Source Type: research

Association of dental occlusal support with the Prognostic Nutritional Index in patients with esophageal cancer who underwent esophagectomy
AbstractBackgroundThe Prognostic Nutritional Index is useful for predicting surgical risk and overall survival based on preoperative immunological and nutritional status in patients undergoing digestive organ cancer surgery. The purpose of this study was to examine the association between the Prognostic Nutritional Index and dental status in patients with esophageal cancer who underwent esophagectomy.MethodsThis retrospective case –control study included 73 patients who underwent resection of esophageal cancer (69 males, 4 females; age 36–83). General and dental status were evaluated. The Prognostic Nutritional...
Source: Esophagus - June 7, 2020 Category: Gastroenterology Source Type: research

Esophageal squamous cell carcinoma or high-grade dysplasia overlying leiomyoma, rare but not to be neglected
ConclusionsWe must keep in mind that ESCC or high-grade dysplasia can occur overlying leiomyoma. These cases are rare but should not be neglected, especially in high-risk areas for ESCC. These patients can receive appropriate treatment if overdiagnosis or underdiagnosis can be avoided. (Source: Esophagus)
Source: Esophagus - May 30, 2020 Category: Gastroenterology Source Type: research

Safety and usefulness of endoscopic submucosal dissection for early esophageal cancers in elderly patients aged 80  years or older
AbstractBackground and aimEndoscopic submucosal dissection (ESD) for early gastrointestinal (GI) cancers is widely performed as a standard treatment in Japan. Given the increasing life expectancy worldwide, it is naturally regarded that the rate of elderly patients diagnosed with early GI cancer has increased. Available guidelines do not specifically outline how to manage endoscopic therapy for the elderly. The aim of this study was to assess the safety and usefulness of ESD for superficial esophageal squamous cell carcinoma (SESCC) in elderly patients.MethodsWe retrospectively investigated 393 consecutive patients, who un...
Source: Esophagus - May 29, 2020 Category: Gastroenterology Source Type: research

Differences in clinical characteristics between conservative-treatment-response group and refractory (surgical-treatment) group in patients with jackhammer esophagus
ConclusionsJE treatment should be carefully considered because some patients require surgery, whereas others are controlled with conservative treatment alone. A higher DCI value in patients with JE may predict resistance to conservative treatment. (Source: Esophagus)
Source: Esophagus - May 26, 2020 Category: Gastroenterology Source Type: research

Usefulness of linked color imaging in the early detection of superficial esophageal squamous cell carcinomas
This study aimed to investigate the usefulness of LCI in detecting superficial esophageal squamous cell carcinomas (SESCC).MethodsWe enrolled 37 consecutive SESCC patients (46 SESCCs) diagnosed using LCI and blue laser imaging bright mode (BLI-BRT) and treated in Hiroshima University Hospital between April 2018 and November 2018. Eight professional endoscopists compared images obtained on non-magnifying BLI-BRT and LCI versus conventional white light imaging (WLI). Identification and boundary diagnosis of SESCC with LCI and BLI-BRT were compared with WLI. Changes in lesion visibility were clarified. Interobserver agreement...
Source: Esophagus - May 23, 2020 Category: Gastroenterology Source Type: research

A national survey on esophageal perforation: study of cases at accredited institutions by the Japanese Esophagus Society
ConclusionShortening the time from onset to the start of treatment contributes to reduce mortality in patients with esophageal perforation. Moreover, strict medical treatment is necessary to lower the mortality rate of elderly patients with strong inflammation and abscesses in the thoracic cavity. (Source: Esophagus)
Source: Esophagus - May 15, 2020 Category: Gastroenterology Source Type: research

Peroral endoscopic myotomy is a safe and effective treatment modality for geriatric patients with achalasia
AbstractBackgroundPeroral endoscopic myotomy (POEM) is an appealing treatment for older patients, as it is minimally invasive but highly efficacious similar to surgical myotomy. However, there is a lack of systematic studies analyzing POEM outcomes in young (
Source: Esophagus - May 11, 2020 Category: Gastroenterology Source Type: research

Efficacy of prewarming prophylaxis method for intraoperative hypothermia during thoracoscopic esophagectomy
This study was performed to elucidate the clinical efficacy of the prewarming prophylaxis method for intraoperative hypothermia during thoracoscopic esophagectomy for esophageal cancer.MethodsWe enrolled 100 consecutive patients with esophageal cancer. Two patients in the prewarming group could not undergo thoracoscopic esophagectomy because of conversion to thoracotomy. The intraoperative core temperature was measured in 50 and 48 patients classified into the control and prewarming groups, respectively. Patients in the prewarming group wore a Bair Hugger warming gown (3  M, Maplewood, MN, USA) in the ward for 30 ...
Source: Esophagus - May 8, 2020 Category: Gastroenterology Source Type: research

Columnar epithelium morphology after esophagectomy: clinical insight into the development of Barrett ’s esophagus
AbstractBackgroundThe presence of Barrett ’s mucosa in the esophageal remnant is a result of post-esophagectomy anastomotic site exposure to gastric acid and is regarded as a human model of Barrett’s esophagus onset. Here, we attempted to clarify the relationship between duodenogastric reflux and formation of columnar epithelium by foll owing the changes over time after esophagectomy.MethodsA total of 96 patients underwent esophagectomy due to superficial cancer from April 2000 to March 2018 were included in this study. Cases were divided into two groups according to the reconstruction technique after esophagec...
Source: Esophagus - May 7, 2020 Category: Gastroenterology Source Type: research

Corrosive ingestion managements in children
AbstractCorrosive (caustic) material ingestion remains a major health issue, particularly in developing countries. The management strategy after corrosive ingestion should be planned according to the signs and symptoms. The management of corrosive ingestion based on endoscopic grading, nothing by mouth, and barium studies should be abandoned. With the new management protocol, esophageal stricture can be predicted with high accuracy using the simple new prognostic DROOL score ( ≤ 4) rather than endoscopic grading, reduced by immediate oral feeding as soon as the patient can swallow saliva instead of nothing by mou...
Source: Esophagus - May 5, 2020 Category: Gastroenterology Source Type: research

Peroral endoscopic shorter versus longer myotomy for the treatment of achalasia: a comparative retrospective study
AbstractIntroductionPeroral esophageal myotomy (POEM) is a novel endoscopic treatment for achalasia. It has gained popularity worldwide among surgeons and endoscopists, but no studies have compared peroral endoscopic short with long myotomy for achalasia. We aimed to compare the clinical efficacy and safety between peroral endoscopic shorter and longer myotomy.MethodsThe retrospective study enrolled 129 achalasia patients who underwent POEM from July 2011 to September 2017. Based on the myotomy length (ML), patients were divided into shorter myotomy (SM) group (ML  ≤ 7 cm,n = 36) and lon...
Source: Esophagus - May 2, 2020 Category: Gastroenterology Source Type: research

Distal contractile integral measurement and vascular compression in the esophagus: a problem unsolved?
ConclusionsSVC is a common finding in esophageal HRM study, particularly in the supine position. Occasionally, its contribution to DCI value is sufficiently great to masquerade esophageal hypocontractility. Different manometric protocols may be required in patients with SVC. (Source: Esophagus)
Source: Esophagus - April 30, 2020 Category: Gastroenterology Source Type: research

The association of primary tumor site with acute adverse event and efficacy of definitive chemoradiotherapy for cStage II/III esophageal cancer: an exploratory analysis of JCOG0909
ConclusionsIn JCOG0909, the incidence of severe hematological toxicity had a trend toward higher in the Mt and Lt than the Ut esophageal cancer; however, no remarkable difference by primary sites was observed with respect to efficacy endpoints. (Source: Esophagus)
Source: Esophagus - April 28, 2020 Category: Gastroenterology Source Type: research

The perioperative presepsin as an accurate diagnostic marker of postoperative infectious complications after esophagectomy: a prospective cohort study
ConclusionsPresepsin levels on POD 5 and 7 after esophagectomy are a valuable indicator of infectious complication ’s detection vs. leukocyte, C-reacted protein, and procalcitonin. (Source: Esophagus)
Source: Esophagus - April 17, 2020 Category: Gastroenterology Source Type: research

Circumferential Heller myotomy can relieve chest pain in patients with achalasia: a prospective clinical trial
ConclusionsThere is promising early evidence that circumferential Heller myotomy may be effective in the treatment of achalasia-related chest pain. Further research, including larger randomized studies with long-term follow-up, is warranted. (Source: Esophagus)
Source: Esophagus - April 4, 2020 Category: Gastroenterology Source Type: research

Holographic image-guided thoracoscopic surgery: possibility of usefulness for esophageal cancer patients with abnormal artery
ConclusionsHolographic image-guided thoracoscopic esophagectomy using wearable holographic computer provided better spatial recognition of vascular variation and safe lymph node dissection. (Source: Esophagus)
Source: Esophagus - April 3, 2020 Category: Gastroenterology Source Type: research

ATP6V0D2, a subunit associated with proton transport, serves an oncogenic role in esophagus cancer and is correlated with epithelial –mesenchymal transition
ConclusionATP6V0D2 might be an independent prognosticator for EC patients, and it possibly promotes tumorigenesis by regulating epithelial –mesenchymal transition, cell cycle and apoptosis-related markers, providing the possibility that ATP6V0D2 may be a novel biomarker for the therapeutic intervention of EC. (Source: Esophagus)
Source: Esophagus - April 2, 2020 Category: Gastroenterology Source Type: research

Review of early endoscopic findings in patients with local recurrence after definitive chemoradiotherapy for esophageal squamous cell carcinoma
ConclusionsEndoscopists should be aware that SMTs or erosions, even those smaller than 10  mm, can indicate local recurrence after complete response to definitive chemoradiotherapy. Follow-up endoscopy should be performed within 1–2 months if findings suggestive of local recurrence are observed on prior endoscopy, even when biopsy results are negative. (Source: Esophagus)
Source: Esophagus - March 30, 2020 Category: Gastroenterology Source Type: research

Argon plasma coagulation for superficial squamous cell carcinoma in the residual esophagus after esophagectomy
ConclusionsAPC was a safe treatment that was easy to perform. APC was concluded to be an effective treatment for superficial SCC in the residual esophagus after esophagectomy when endoscopic resection was difficult. (Source: Esophagus)
Source: Esophagus - March 24, 2020 Category: Gastroenterology Source Type: research

Prophylactic steroid administration against strictures is not enough for mucosal defects involving the entire circumference of the esophageal lumen after esophageal endoscopic submucosal dissection (ESD)
ConclusionAlthough additional study is required in a larger number of patients, careful consideration needs to be given to ESD as an indication for large spreading ESCC involving the entire circumference of esophagus given its high stricture risk. (Source: Esophagus)
Source: Esophagus - March 14, 2020 Category: Gastroenterology Source Type: research

Clinical impact of baseline renal function on the safety of radiotherapy with concurrent docetaxel for esophageal cancer in elderly patients
AbstractBackgroundWe aimed to compare the safety of radiotherapy with concurrent docetaxel (DOC-RT) for esophageal cancer (EC) in elderly patients who were divided into a creatinine clearance (Ccr)  
Source: Esophagus - March 13, 2020 Category: Gastroenterology Source Type: research

High TLR4 expression predicts a poor prognosis after esophagectomy for advanced thoracic esophageal squamous cell carcinoma
AbstractBackgroundPoor oral health is an independent risk factor for upper aerodigestive tract cancers, including esophageal squamous cell carcinoma (ESCC). The pattern recognition receptor Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide in the cell walls of Gram-negative periodontal pathogens associated with the development and progression of ESCC. It is, therefore, plausible that TLR4 plays a crucial role in the pathogenesis of ESCC.MethodsWe used an ESCC tissue microarray to confirm expression of TLR4 in patients with ESCC and to determine whether TLR4 expression status correlates with the clinicopathological ...
Source: Esophagus - March 13, 2020 Category: Gastroenterology Source Type: research

Clinical and endoscopic characteristics of diffuse esophageal intramural pseudo-diverticulosis
ConclusionWith a prevalence of approximately 5 to 50/100.000, DEIPD may be more frequent than previously estimated. It preferably affects middle-aged male alcoholics. Key symptoms are chronic dysphagia and food impaction. Typical endoscopic findings are multiple, small, longitudinally aligned pseudodiverticle openings, frosted glass look, faux uni pattern, and trachealization of the esophagus. (Source: Esophagus)
Source: Esophagus - March 11, 2020 Category: Gastroenterology Source Type: research

LncRNA-IUR up-regulates PTEN by sponging miR-21 to regulate cancer cell proliferation and apoptosis in esophageal squamous cell carcinoma
ConclusionTherefore, IUR may up-regulate PTEN by sponging miR-21 to regulate cancer cell proliferation and apoptosis in ESCC. (Source: Esophagus)
Source: Esophagus - March 2, 2020 Category: Gastroenterology Source Type: research

Anomalies of the right vertebral vein increasing the difficulty of lymph-node dissection along the right recurrent laryngeal nerve: a single-institution, retrospective study
AbstractBackgroundRadical lymph-node dissection along the recurrent laryngeal nerves (RLN) improves the prognosis of patients with esophageal cancer. The RLN is a landmark for achieving adequate lymph-node dissection. However, the right RLN is sometimes covered by the right vertebral veins (VVs), making it undetectable. We investigated the relationship between this anomaly of the right VVs and the challenges of performing lymphadenectomy along the right RLN.MethodsPatients with esophageal cancer, who underwent thoracoscopic esophagectomy with radical lymph-node dissection, were registered. The patterns of the right VVs wer...
Source: Esophagus - February 22, 2020 Category: Gastroenterology Source Type: research

Chemoradiotherapy and radiotherapy alone in patients with esophageal cancer aged 80  years or older based on the Comprehensive Registry of Esophageal Cancer in Japan
AbstractBackgroundThere has been no definitive evidence of chemoradiotherapy being superior to radiotherapy alone in patients aged 80  years or older. The purpose of the present study was to evaluate the results of radiotherapy and chemoradiotherapy in patients aged 80 years or older with esophageal cancer in the Japanese Nationwide Cancer Database.MethodsA total of 358 patients aged 80  years or older who were treated with radiotherapy alone or with chemoradiotherapy for esophageal cancer between 2009 and 2011 were enrolled.ResultsThe 5-year overall survival (OS) rates in patients with cStages 0 –I, I...
Source: Esophagus - February 22, 2020 Category: Gastroenterology Source Type: research

Factors affecting the outcome of endoscopic dilatation in refractory post-corrosive oesophageal stricture in Egyptian children: a single-centre study
ConclusionEndoscopic dilation is an effective method for managing refractory post-corrosive oesophageal strictures that require a long follow-up period. There are a lot of factors affecting the outcome. (Source: Esophagus)
Source: Esophagus - February 22, 2020 Category: Gastroenterology Source Type: research

Predictors of reflux aspiration and laryngo-pharyngeal reflux
AbstractBackgroundGastro-esophageal reflux disease (GERD) can present with typical or atypical or laryngo-pharyngeal reflux (LPR) symptoms. Pulmonary aspiration of gastric refluxate is one of the most serious variants of reflux disease as its complications are difficult to diagnose and treat. The aim of this study was to establish predictors of pulmonary aspiration and LPR symptoms.MethodsRecords of 361 consecutive patient from a prospectively populated database were analyzed. Patients were categorized by symptom profile as predominantly LPR or GERD (98 GER and 263 LPR). Presenting symptom profile, pH studies, esophageal m...
Source: Esophagus - February 21, 2020 Category: Gastroenterology Source Type: research

Revisiting radiation therapy for esophageal cancer
(Source: Esophagus)
Source: Esophagus - February 20, 2020 Category: Gastroenterology Source Type: research

Utility of Valsalva maneuver in the endoscopic pharyngeal observation
AbstractBackgroundMetachronous cancer rate in the pharynx is high before and after the treatment of esophageal cancer. Endoscopic observation is difficult in the pharynx especially in the postcricoid area. Pharyngeal cancer in the postcricoid area has been often found in advanced stage. Valsalva maneuver has been reported to improve the visibility.MethodsFrom May 2017 we introduced a dedicated mouthpiece to conduct Valsalva maneuver. One hundred consecutive patients who had been observed throughout the pharynx by one endoscopist were enrolled. A total of 200 image files before and after introduction were made and reviewed ...
Source: Esophagus - February 18, 2020 Category: Gastroenterology Source Type: research

Multidisciplinary team management for prevention of pneumonia and long-term weight loss after esophagectomy: a single-center retrospective study
AbstractBackgroundIn April 2017, we launched the multidisciplinary Hamamatsu Perioperative Care Team (HOPE) for all surgical patients. We developed a reinforced intervention strategy, particularly for esophagectomy. We herein report the outcomes of the HOPE at 2  years after commencement.MethodsA total 125 patients underwent esophagectomy and gastric conduit reconstruction for esophageal or esophagogastric junction cancer between January 2014 and December 2018 at the Department of Surgery in Hamamatsu University School of Medicine. The patients were divided into the pre-HOPE group including 62 patients who underwent e...
Source: Esophagus - February 6, 2020 Category: Gastroenterology Source Type: research

Pseudoachalasia: a systematic review of the literature
AbstractPseudoachalasia, also known as secondary achalasia, is a clinical condition mimicking idiopathic achalasia but most commonly caused by malignant tumors of gastroesophageal junction (GEJ). Our aim was to systematically review and present all available data on demographics, clinical features, and diagnostic modalities involved in patients with pseudoachalasia. A systematic search of literature published during the period 1978 –2019 was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (end-of-search date: June 25th, 2019). Two independent rev...
Source: Esophagus - January 27, 2020 Category: Gastroenterology Source Type: research

Clinical utility of salivary pepsin measurement in patients with proton pump inhibitor-refractory gastroesophageal reflux disease symptoms: a prospective comparative study
ConclusionsIn patients with PPI-refractory nonerosive reflux disease, salivary pepsin measurement may help diagnose patients who have conclusive evidence of reflux, whereas it is not adequate for identifying patients with APE. (Source: Esophagus)
Source: Esophagus - January 25, 2020 Category: Gastroenterology Source Type: research

Application of artificial intelligence using convolutional neural networks in determining the invasion depth of esophageal squamous cell carcinoma
ConclusionsThe AI-diagnostic system demonstrated a higher diagnostic accuracy for ESCC invasion depth than those of endoscopists and, therefore, can be potentially used in ESCC diagnostics. (Source: Esophagus)
Source: Esophagus - January 24, 2020 Category: Gastroenterology Source Type: research