Association between ABCC2 polymorphism and hematological toxicity in patients with esophageal cancer receiving platinum plus 5-fluorouracil therapy
ConclusionsWe determined thatABCC2−24C>T is significantly associated with grade 3 –4 hematological toxicity after platinum plus 5-FU therapy. These findings might contribute to improved treatment strategies for patients with esophageal cancer. (Source: Esophagus)
Source: Esophagus - August 4, 2021 Category: Gastroenterology Source Type: research
Preoperative low serum creatine kinase is associated with poor overall survival in the male patients with esophageal squamous cell carcinoma
ConclusionsPreoperative low serum creatine kinase level was useful in predicting overall survival in the male patients with esophageal squamous cell carcinoma. (Source: Esophagus)
Source: Esophagus - August 3, 2021 Category: Gastroenterology Source Type: research
Effectiveness of lymphadenectomy along the thoracic duct for radical esophagectomy
ConclusionsThe significance of TD resection was low in T0 –2 due to the low metastatic rate but became evident in cases with invasion depth of T3–4. TDLN resection was at least as effective as dissection of other group-2 or -3 lymph nodes, including No. 112 nodes. (Source: Esophagus)
Source: Esophagus - July 31, 2021 Category: Gastroenterology Source Type: research
Paclitaxel plus cisplatin and 5-fluorouracil induction chemotherapy for locally advanced borderline-resectable esophageal squamous cell carcinoma: a phase II clinical trial
ConclusionsThe treatment strategy of induction chemotherapy followed by surgery is promising for patients with locally advanced BR-ESCC. To further improve the R0 resection rate, more effective induction chemotherapy regimens need to be explored.Trial registrationClinicalTrials.gov identifier: NCT02976909. (Source: Esophagus)
Source: Esophagus - July 28, 2021 Category: Gastroenterology Source Type: research
The effects of hesperidin on stricture formation in corrosive esophageal burns: an experimental study
ConclusionsThis study is the first to use Hesperidin in preventing esophageal damage in an esophageal caustic burn model. It was shown that Hesperidin was effective in reducing macroscopic and microscopic histopathologic damage in the corrosive esophageal burn model, preventing the stricture formation, and has positive effects on nutrition in rats with an esophageal burn. (Source: Esophagus)
Source: Esophagus - July 26, 2021 Category: Gastroenterology Source Type: research
Per-oral endoscopic dual myotomy for the treatment of achalasia
ConclusionDual-POEM preliminarily demonstrated high efficacy with a favorable safety profile in patients with achalasia with predictors of treatment failure. (Source: Esophagus)
Source: Esophagus - July 17, 2021 Category: Gastroenterology Source Type: research
Changes in the quality of life score following preoperative chemotherapy in elderly patients with esophageal cancer
ConclusionsQuality of life scores of elderly patients with esophageal cancer who received preoperative chemotherapy decreased in terms of physical function but improved in terms of esophageal cancer symptoms and mental function. Our results suggest that alleviation of symptoms contributed to the improvements in mental health. (Source: Esophagus)
Source: Esophagus - July 17, 2021 Category: Gastroenterology Source Type: research
Does thoracoscopic esophagectomy really reduce post-operative pneumonia in all cases?
In conclusion, unlike RCTs and CLIs, CNDs did not show the superiority of thoracoscopic surgery in terms of post-operative pneumonia. RCTs and CLIs were predominantly performed by high-volume hospitals, while CNDs were often performed by low-volume hospitals. In actual clinical practic e including various types of hospitals, the superiority of thoracoscopic over open esophagectomy regarding the incidence of pneumonia may, therefore, decrease. (Source: Esophagus)
Source: Esophagus - July 10, 2021 Category: Gastroenterology Source Type: research
Diagnostic utility of a novel magnifying endoscopic classification system for superficial Barrett ’s esophagus-related neoplasms: a nationwide multicenter study
ConclusionThe JES-BE classification system, including the diagnostic flowchart for predicting dysplastic BE, is acceptable and reliable, regardless of the clinician ’s experience level. (Source: Esophagus)
Source: Esophagus - May 30, 2021 Category: Gastroenterology Source Type: research
Delineating the extent of esophageal squamous cell carcinoma
ConclusionsNBI might be acceptable for delineating the extent of esophageal SCCs that are difficult to delineate with Lugol chromoendoscopy. (Source: Esophagus)
Source: Esophagus - May 29, 2021 Category: Gastroenterology Source Type: research
Peri-anastomotic microdialysis lactate assessment after esophagectomy
ConclusionApplication and use of the novel CliniSenz® analyser system, in combination with the OnZurf® Probe was feasible and safe. Continuous monitoring of analytes from the perianastomotic area has the potential to improve care after esophageal resection. (Source: Esophagus)
Source: Esophagus - May 29, 2021 Category: Gastroenterology Source Type: research
Development of imaging biomarker for esophageal cancer using intravoxel incoherent motion MRI
ConclusionsQuantification of tumor perfusion using IVIM-MRI can be a non-invasive prognostic biomarker of ESCC, reflecting clinical stage and survival. (Source: Esophagus)
Source: Esophagus - May 21, 2021 Category: Gastroenterology Source Type: research
Usefulness of prone-position computed tomography as preoperative simulation prior to thoracoscopic esophagectomy for thoracic esophageal cancer
ConclusionsThis study indicates that preoperative prone-position CT imaging is useful for predicting the level of ease or difficulty of securing an adequate operative field, surgical outcomes, and the risk of postoperative pneumonia in MIE. (Source: Esophagus)
Source: Esophagus - May 17, 2021 Category: Gastroenterology Source Type: research
Early intervention of the perioperative multidisciplinary team approach decreases the adverse events during neoadjuvant chemotherapy for esophageal cancer patients
ConclusionThe MDT approach should be started before NAC in patients undergoing esophageal cancer surgery to prevent adverse events during chemotherapy and provide safe perioperative conditions. (Source: Esophagus)
Source: Esophagus - May 17, 2021 Category: Gastroenterology Source Type: research
Clinical usefulness of sputum culture on the first postoperative day to predict early postoperative pneumonia after esophagectomy for esophageal cancer
ConclusionsDetection of target bacterial species by sputum culture on the first postoperative day after esophagectomy was an independent risk factor of postoperative pneumonia within 7 days after surgery. Prospective studies for the prevention of early postoperative pneumonia using sputum culture on the first postoperative day can be considered. (Source: Esophagus)
Source: Esophagus - May 16, 2021 Category: Gastroenterology Source Type: research
