Deleterious alterations of DNA damage response and repair genes and clinical benefit to anti-PD-1 therapy in esophageal squamous cell carcinoma
ConclusionsDeleterious alterations of DDR genes may be associated with improved prognosis and efficacy of anti-PD-1 therapy in patients with advanced ESCC. (Source: Esophagus)
Source: Esophagus - July 11, 2022 Category: Gastroenterology Source Type: research
Urinary protein biomarker panel predicts esophageal squamous carcinoma from control cases and other tumors
ConclusionsUrinary biomarker panel represents a promising auxiliary diagnostic tool for ESCC, including early-stage ESCC. (Source: Esophagus)
Source: Esophagus - July 6, 2022 Category: Gastroenterology Source Type: research
Neoadjuvant chemotherapy for locally advanced esophageal cancer comparing cisplatin and 5-fluorouracil versus docetaxel plus cisplatin and 5-fluorouracil: a propensity score matching analysis
ConclusionsPatients receiving DCF had higher pathological response and better survival than those receiving CF, especially in pathological T3 and T4 cases matched using propensity scores. Thus, the DCF regimen might be an effective treatment for locally advanced esophageal cancer. However, the adverse side effects of chemotherapy remain high and should be handled appropriately. (Source: Esophagus)
Source: Esophagus - July 6, 2022 Category: Gastroenterology Source Type: research
Low anti-CFL1 antibody with high anti-ACTB antibody is a poor prognostic factor in esophageal squamous cell carcinoma
ConclusionsSerum levels of anti-CFL1 and anti-ACTB antibodies were significantly higher in patients with esophageal carcinoma than in healthy donors. A combination of low anti-CFL1 and high anti-ACTB antibodies is a poor prognostic factor in esophageal carcinoma. (Source: Esophagus)
Source: Esophagus - July 3, 2022 Category: Gastroenterology Source Type: research
The benefit of concurrent chemotherapy with radiotherapy for esophageal cancer is limited in Asian patients aged 80 years or older: a SEER database analysis
ConclusionsIt is controversial whether CRT is beneficial for Asian or Pacific Islander patients aged 80 years or older with esophageal cancer based on Analysis of data in SEER database. (Source: Esophagus)
Source: Esophagus - July 2, 2022 Category: Gastroenterology Source Type: research
Clinical use of mean nocturnal baseline impedance and post-reflux swallow-induced peristaltic wave index for the diagnosis of gastro-esophageal reflux disease
AbstractThe clinical diagnosis of gastro-esophageal reflux disease (GERD) is based on the presence of typical esophageal troublesome symptoms. In clinical practice, heartburn relief following a proton pump inhibitor (PPI) trial or endoscopy can confirm a diagnosis of GERD. In cases of diagnostic uncertainty or before anti-reflux interventions, combined impedance-pH monitoring (MII-pH) provides a comprehensive assessment of both physical and chemical properties of the refluxate, allowing to achieve a conclusive diagnosis of GERD. Recently, the Lyon Consensus proposed the use of mean nocturnal baseline impedance (MNBI) and p...
Source: Esophagus - June 29, 2022 Category: Gastroenterology Source Type: research
Risk of fractures in individuals with eosinophilic esophagitis: nationwide population-based cohort study
ConclusionThe risk of fracture in EoE was not statistically significantly elevated compared to non-EoE reference individuals. Fracture risk in EoE was not modified by PPIs or steroid use. (Source: Esophagus)
Source: Esophagus - June 28, 2022 Category: Gastroenterology Source Type: research
Factors affecting the completion of concurrent chemotherapy and impact of non-completion on survival in locally advanced esophageal squamous cell carcinoma
ConclusionCCT completion can provide superior OS for ESCC patients treated with definitive CCRT. Weekly CCT regimen, CTV-ENI, PTV, older age, and tumor location are independent predictors of non-completion of CCT. (Source: Esophagus)
Source: Esophagus - June 27, 2022 Category: Gastroenterology Source Type: research
Correction to: Esophageal cancer practice guidelines 2017 edited by the Japan Esophageal Society: part 1 and Part 2
(Source: Esophagus)
Source: Esophagus - June 27, 2022 Category: Gastroenterology Source Type: research
A phase II study of S-1 therapy for patients with advanced and recurrent esophageal cancer resistant or intolerable to fluorouracil, platinum, and taxane therapy (OGSG 1404)
ConclusionsAlthough this trial closed early because of slow accrual, we observed modest clinical activity with S-1 in patients with R/M ESCC who could not tolerate or whose tumors were refractory to FU, PT, and TAX therapy. (Source: Esophagus)
Source: Esophagus - June 20, 2022 Category: Gastroenterology Source Type: research
International trends in esophageal cancer incidence rates by histological subtype (1990 –2012) and prediction of the rates to 2030
ConclusionsDecreasing trends in ESCC have been observed worldwide in both low- and middle-income countries and high-income countries, which may have been offset by increasing trends in EAC in high-income countries. The changing patterns of these two main subtypes of esophageal cancer may call for interventions, especially innovative interventions, to address obesity, GERD, and Barrett's esophagus. (Source: Esophagus)
Source: Esophagus - June 11, 2022 Category: Gastroenterology Source Type: research
First-line pembrolizumab + chemotherapy in Japanese patients with advanced/metastatic esophageal cancer from KEYNOTE-590
ConclusionFirst-line pembrolizumab plus chemotherapy demonstrated improvement in overall survival and progression-free survival compared with placebo plus chemotherapy in Japanese patients with advanced/metastatic esophageal cancer; safety was comparable between treatment groups.Clinical trial registryClinicalTrials.gov, NCT03189719. (Source: Esophagus)
Source: Esophagus - June 7, 2022 Category: Gastroenterology Source Type: research
Distal esophageal wall thickness correlates with dysphagia in adult patients with eosinophilic esophagitis
ConclusionDistal esophageal wall thickness positively correlates with dysphagia score in EoE but not GERD. This appears to be related to the composition of the submucosa which can be identified using EUS. (Source: Esophagus)
Source: Esophagus - June 6, 2022 Category: Gastroenterology Source Type: research
Handgrip strength predicts early postoperative dysphagia after thoracoscopic –laparoscopic esophagectomy in male patients with esophageal cancer
ConclusionsLow HGS was significantly associated with early postoperative aspiration and impairment of airway protective reflexes after TLE. (Source: Esophagus)
Source: Esophagus - June 5, 2022 Category: Gastroenterology Source Type: research
Increasing incidence of eosinophilic esophagitis in Sweden: a nationwide population study
ConclusionsEoE seems to be increasing in Sweden, with an overall age-standardized incidence of EoE of 1.22 per 100,000 person-years in the last decade. (Source: Esophagus)
Source: Esophagus - June 2, 2022 Category: Gastroenterology Source Type: research
